Detailed information for compound 1411115

Basic information

Technical information
  • TDR Targets ID: 1411115
  • Name: 5-{[3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5- yl]amino}-3,3-dimethyl-5-oxopentanoic acid
  • MW: 349.812 | Formula: C17H20ClN3O3
  • H donors: 2 H acceptors: 4 LogP: 2.65 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cc(nn1C)c1ccc(cc1)Cl)CC(CC(=O)O)(C)C
  • InChi: 1S/C17H20ClN3O3/c1-17(2,10-16(23)24)9-15(22)19-14-8-13(20-21(14)3)11-4-6-12(18)7-5-11/h4-8H,9-10H2,1-3H3,(H,19,22)(H,23,24)
  • InChiKey: ZTTZBWMFYNGJFG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • MLS000850363
  • SMR000456381
  • Maybridge3_002612
  • Oprea1_193146
  • HTS 08050
  • IDI1_013999

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis tubulin beta chain, putative 0.0017 0.0056 0.022
Trichomonas vaginalis tubulin beta chain, putative 0.0017 0.0056 0.022
Leishmania major cytochrome p450-like protein 0.0022 0.0107 0.0197
Echinococcus multilocularis Tubulin alpha 1 chain 0.0017 0.0056 0.1205
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0022 0.0107 0.5
Schistosoma mansoni hypothetical protein 0.0031 0.02 0.3432
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.172 0.676
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0107 0.5
Echinococcus granulosus tubulin alpha 1C chain 0.0017 0.0056 0.1205
Schistosoma mansoni alpha tubulin 0.0017 0.0056 0.0947
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0022 0.0107 0.5
Entamoeba histolytica tubulin alpha chain, putative 0.0017 0.0056 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0001 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0107 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0107 0.042
Brugia malayi Cytochrome P450 family protein 0.0022 0.0107 0.0146
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.02 0.0274
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0456 0.7858
Schistosoma mansoni alpha tubulin 0.0017 0.0056 0.0947
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0907 0.1252
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0017 0.0056 0.022
Schistosoma mansoni alpha tubulin 0.0017 0.0056 0.0947
Brugia malayi alpha-tubulin 0.0017 0.0056 0.0076
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0022 0.0107 0.5
Loa Loa (eye worm) tubulin alpha chain 0.0017 0.0056 0.022
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.2544 1
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1625 0.6389
Plasmodium falciparum telomerase reverse transcriptase 0.0262 0.2639 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0001 0.0005
Brugia malayi Telomerase reverse transcriptase 0.0697 0.7234 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0107 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0005
Loa Loa (eye worm) tubulin alpha chain 0.0017 0.0056 0.022
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0022 0.0107 0.5
Echinococcus multilocularis tubulin alpha chain 0.0017 0.0056 0.1205
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0262 0.2639 1
Echinococcus multilocularis tubulin alpha chain 0.0017 0.0056 0.1205
Trypanosoma brucei telomerase reverse transcriptase 0.0262 0.2639 1
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0022 0.0107 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1625 0.6389
Brugia malayi Tubulin alpha chain 0.0017 0.0056 0.0076
Echinococcus granulosus tubulin alpha chain 0.0017 0.0056 0.1205
Echinococcus multilocularis tubulin alpha 1C chain 0.0017 0.0056 0.1205
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0456 0.7858
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.02 0.0785
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0022 0.0107 0.5
Echinococcus granulosus Tubulin alpha 1 chain 0.0017 0.0056 0.1205
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1625 0.6389
Trichomonas vaginalis tubulin epsilon chain, putative 0.0017 0.0056 0.022
Brugia malayi Cytochrome P450 family protein 0.0022 0.0107 0.0146
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0107 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.172 0.676
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0005
Echinococcus granulosus GPCR family 2 0.0031 0.02 0.4367
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0107 0.5
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0013 0.0013 0.0051
Echinococcus granulosus tubulin subunit TubB 0.0017 0.0056 0.1205
Schistosoma mansoni tubulin subunit alpha 0.0017 0.0056 0.0947
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0005
Echinococcus granulosus tubulin alpha 3 chain 0.0017 0.0056 0.1205
Schistosoma mansoni hypothetical protein 0.0022 0.0107 0.1827
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0907 0.3564
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0022 0.0107 0.5
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0107 0.0197
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.02 0.4367
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2544 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0022 0.0107 0.5
Schistosoma mansoni hypothetical protein 0.0067 0.0579 1
Trichomonas vaginalis tubulin beta chain, putative 0.0017 0.0056 0.022
Echinococcus multilocularis tubulin alpha chain 0.0017 0.0056 0.1205
Brugia malayi cytochrome P450 0.0022 0.0107 0.0146
Echinococcus granulosus Tubulin alpha 1 chain 0.0017 0.0056 0.1205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0001 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0456 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0107 0.0197
Brugia malayi Latrophilin receptor protein 2 0.0031 0.02 0.0274
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1625 0.6389
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0022 0.0107 0.5
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0022 0.0107 0.5
Loa Loa (eye worm) hypothetical protein 0.0098 0.0907 0.3564
Loa Loa (eye worm) alpha-tubulin 0.0017 0.0056 0.022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0001 0.0005
Echinococcus multilocularis 0.0022 0.0107 0.2325
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0022 0.0107 0.5
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0107 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0579 0.0799
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0107 0.5
Echinococcus granulosus tubulin alpha 1C chain 0.0017 0.0056 0.1205
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0107 0.5
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0107 0.0197
Echinococcus multilocularis GPCR, family 2 0.0031 0.02 0.4367
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0107 0.042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0005
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0107 0.0197
Leishmania major cytochrome p450-like protein 0.0022 0.0107 0.0197
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0107 0.5
Echinococcus multilocularis Tubulin alpha 1 chain 0.0017 0.0056 0.1205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0001 0.0005
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0022 0.0107 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0456 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0456 1
Loa Loa (eye worm) tubulin alpha 2 0.0013 0.0013 0.0051
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.02 0.4367
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2544 1
Echinococcus multilocularis tubulin alpha chain 0.0017 0.0056 0.1205
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0456 0.1791
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0051
Mycobacterium leprae putative cytochrome p450 0.0022 0.0107 0.5
Echinococcus multilocularis tubulin alpha 3 chain 0.0017 0.0056 0.1205
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0107 0.0197
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0005
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0107 0.5
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0107 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0001 0.0005
Brugia malayi Tubulin alpha-2 chain 0.0017 0.0056 0.0076
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.02 0.4367
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0107 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.02 0.0785
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0022 0.0107 0.5
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0022 0.0107 0.5
Echinococcus granulosus Tubulin alpha 1 chain 0.0017 0.0056 0.1205
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0907 0.1252
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0001 0.0005
Leishmania major telomerase reverse transcriptase, putative 0.0262 0.2639 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0107 0.5
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0107 0.5
Schistosoma mansoni hypothetical protein 0.0031 0.02 0.3432
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0005
Echinococcus multilocularis tubulin subunit TubB 0.0017 0.0056 0.1205
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0022 0.0107 0.5
Loa Loa (eye worm) hypothetical protein 0.0067 0.0579 0.2278
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.1625 0.1624
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0107 0.0197
Trichomonas vaginalis tubulin epsilon chain, putative 0.0017 0.0056 0.022
Giardia lamblia Telomerase catalytic subunit 0.0262 0.2639 1
Leishmania major cytochrome p450-like protein 0.0022 0.0107 0.0197
Echinococcus multilocularis peroxisome assembly protein 26 0.0017 0.0056 0.1205
Echinococcus granulosus tubulin alpha chain 0.0017 0.0056 0.1205
Echinococcus granulosus tubulin alpha 3 chain 0.0017 0.0056 0.1205
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0262 0.2639 1
Toxoplasma gondii RNA-directed DNA polymerase 0.0262 0.2639 1
Echinococcus multilocularis hypothetical protein 0.0017 0.0056 0.1205
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0022 0.0107 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2544 1
Schistosoma mansoni tubulin subunit alpha 0.0017 0.0056 0.0947
Schistosoma mansoni cytochrome P450 0.0022 0.0107 0.1827
Echinococcus granulosus tubulin alpha chain 0.0017 0.0056 0.1205
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0013 0.0013 0.0051
Brugia malayi tubulin alpha-2 chain 0.0017 0.0056 0.0076
Brugia malayi Cytochrome P450 family protein 0.0022 0.0107 0.0146
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0456 1
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.0107 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.02 0.4367
Trichomonas vaginalis tubulin beta chain, putative 0.0017 0.0056 0.022
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2544 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0022 0.0107 0.5
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0107 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1625 0.6389
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0107 0.2325
Brugia malayi tubulin alpha chain - mouse 0.0017 0.0056 0.0076
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.2544 0.3516
Entamoeba histolytica tubulin alpha-1 chain 0.0017 0.0056 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1625 0.6389
Loa Loa (eye worm) alpha-tubulin 0.0017 0.0056 0.022
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0107 0.0197
Echinococcus multilocularis tubulin alpha 1C chain 0.0017 0.0056 0.1205
Plasmodium vivax telomerase reverse transcriptase, putative 0.0262 0.2639 1
Echinococcus granulosus peroxisome assembly protein 26 0.0017 0.0056 0.1205
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0456 0.7858
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0456 0.0628
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0107 0.5
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0107 0.0197
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0005
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0107 0.042
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0107 0.042
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0022 0.0107 0.5
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0107 0.5
Echinococcus granulosus tubulin alpha chain 0.0017 0.0056 0.1205
Schistosoma mansoni hypothetical protein 0.0031 0.02 0.3432
Schistosoma mansoni tubulin subunit alpha 0.0017 0.0056 0.0947
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0107 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.022
Echinococcus granulosus alpha tubulin 0.0017 0.0056 0.1205
Echinococcus granulosus tubulin alpha chain 0.0017 0.0056 0.1205
Schistosoma mansoni hypothetical protein 0.0031 0.02 0.3432
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1625 0.6389
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0107 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0001 0.0005
Loa Loa (eye worm) tubulin alpha 2 0.0013 0.0013 0.0051
Brugia malayi Tubulin alpha-2 chain 0.0017 0.0056 0.0076
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0022 0.0107 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2544 1
Trichomonas vaginalis tubulin beta chain, putative 0.0017 0.0056 0.022
Loa Loa (eye worm) tubulin alpha-2 chain 0.0017 0.0056 0.022
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0022 0.0107 0.5
Trichomonas vaginalis tubulin beta chain, putative 0.0017 0.0056 0.022
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0107 0.5
Loa Loa (eye worm) cytochrome P450 0.0022 0.0107 0.042
Brugia malayi Cytochrome P450 family protein 0.0022 0.0107 0.0146
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0107 0.0197
Echinococcus multilocularis tubulin alpha 3 chain 0.0017 0.0056 0.1205
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0107 0.5
Echinococcus multilocularis Tubulin alpha 1 chain 0.0017 0.0056 0.1205
Echinococcus multilocularis tubulin alpha chain 0.0017 0.0056 0.1205
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2544 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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