Detailed information for compound 1411796

Basic information

Technical information
  • TDR Targets ID: 1411796
  • Name: 2-[2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]eth yl]isoindole-1,3-dione
  • MW: 304.387 | Formula: C14H12N2O2S2
  • H donors: 0 H acceptors: 3 LogP: 2.87 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1csc(n1)SCCN1C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C14H12N2O2S2/c1-9-8-20-14(15-9)19-7-6-16-12(17)10-4-2-3-5-11(10)13(16)18/h2-5,8H,6-7H2,1H3
  • InChiKey: ISAUGXWKBPULRV-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[2-(4-methylthiazol-2-yl)sulfanylethyl]isoindoline-1,3-dione
  • 2-[2-[(4-methyl-2-thiazolyl)thio]ethyl]isoindoline-1,3-dione
  • 2-[2-[(4-methylthiazol-2-yl)thio]ethyl]isoindoline-1,3-quinone
  • ZINC03413792
  • MLS000098436
  • SMR000065182
  • T5420043

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glucosamine-1-phosphate N-acetyltransferase 0.0023 0.003 0.1318
Entamoeba histolytica serine acetyltransferase 1 0.0023 0.003 0.134
Trypanosoma brucei nucleotidyl transferase, putative 0.0023 0.003 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0029 0.1295
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0095 0.4169
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0007 0.0817
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0007 0.0039
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0026 0.8393
Echinococcus multilocularis expressed conserved protein 0.0112 0.0211 0.1064
Entamoeba histolytica maltose O-acetyltransferase, putative 0.0023 0.003 0.134
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.003 1
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0007 0.0817
Entamoeba histolytica hypothetical protein 0.0043 0.0071 0.3171
Entamoeba histolytica acetyltransferase, putative 0.0023 0.003 0.134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0095 0.4169
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0041 0.1176
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0007 0.2352
Trypanosoma brucei GDP-mannose pyrophosphorylase 0.0023 0.003 1
Schistosoma mansoni ap endonuclease 0.0023 0.0029 0.1274
Schistosoma mansoni mannose-1-phosphate guanyltransferase 0.0023 0.003 0.1318
Onchocerca volvulus 0.0012 0.0007 0.1722
Chlamydia trachomatis UDP-3-O-acylglucosamine N-acyltransferase 0.0023 0.003 1
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0329 0.1664
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0029 0.0122
Entamoeba histolytica hypothetical protein 0.0043 0.0071 0.3171
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0095 0.0482
Loa Loa (eye worm) hypothetical protein 0.0051 0.0087 0.2478
Echinococcus granulosus expressed conserved protein 0.0112 0.0211 0.6005
Entamoeba histolytica serine acetyltransferase, putative 0.0023 0.003 0.134
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0029 0.0832
Schistosoma mansoni hypothetical protein 0.0023 0.003 0.1318
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.0023 0.003 0.134
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0229 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0203
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.4914 1 1
Brugia malayi zgc:92842 0.0023 0.003 0.0861
Mycobacterium ulcerans hypothetical protein 0.0901 0.182 0.182
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0007 0.031
Trypanosoma cruzi hypothetical protein 0.0023 0.003 1
Echinococcus granulosus dynactin 5 p25 0.0023 0.003 0.0861
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0225 0.1138
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0755
Loa Loa (eye worm) hypothetical protein 0.018 0.0351 1
Loa Loa (eye worm) dynactin 5 0.0023 0.003 0.0861
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0029 0.9661
Leishmania major hypothetical protein, conserved 0.0023 0.003 0.7321
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0095 0.0482
Mycobacterium tuberculosis Possible siderophore-binding protein 0.0023 0.003 0.003
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0023 0.003 0.3474
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0024 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0007 0.0817
Mycobacterium ulcerans serine acetyltransferase CysE 0.0023 0.003 0.003
Brugia malayi hypothetical protein 0.0023 0.003 0.0861
Trichomonas vaginalis sugar-1-phosphate guanyl transferase, putative 0.0023 0.003 0.3474
Mycobacterium ulcerans transferase 0.0023 0.003 0.003
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0087 0.2478
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0023 0.003 0.0861
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0041 1
Toxoplasma gondii eukaryotic initiation factor-2B, epsilon subunit, putative 0.0023 0.003 0.0166
Wolbachia endosymbiont of Brugia malayi 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 0.0023 0.003 0.0023
Brugia malayi Muscleblind-like protein 0.018 0.0351 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0041 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0029 0.3357
Giardia lamblia Translation initiation factor 0.0023 0.003 1
Echinococcus granulosus nibrin 0.0012 0.0007 0.0203
Leishmania major hypothetical protein, conserved 0.0023 0.003 0.7321
Echinococcus granulosus mannose 1 phosphate guanyltransferase 0.0023 0.003 0.0861
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0023 0.003 0.0861
Toxoplasma gondii eukaryotic initiation factor 2B epsilon subunit, putative 0.0023 0.003 0.0166
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.003 1
Brugia malayi hypothetical protein 0.0023 0.003 0.0861
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0029 0.0029
Chlamydia trachomatis acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase 0.0023 0.003 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0041 0.0041
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0026 0.0026
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0041 0.183
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0029 0.9661
Plasmodium falciparum dynactin subunit 5, putative 0.0023 0.003 1
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0225 0.6424
Brugia malayi hypothetical protein 0.0023 0.003 0.0861
Brugia malayi hypothetical protein 0.0012 0.0007 0.0203
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0024
Mycobacterium tuberculosis Conserved hypothetical protein 0.0901 0.182 0.182
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.0023 0.003 0.134
Loa Loa (eye worm) hypothetical protein 0.0119 0.0225 0.6424
Brugia malayi topoisomerase 0.0012 0.0007 0.0203
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0861
Schistosoma mansoni patched 1 0.0051 0.0087 0.3794
Trichomonas vaginalis glucose-1-phosphate thymidylyltransferase, putative 0.0023 0.003 0.3474
Schistosoma mansoni hypothetical protein 0.0049 0.0083 0.363
Brugia malayi eIF4-gamma/eIF5/eIF2-epsilon family protein 0.0023 0.003 0.0861
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.003 0.3474
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.1979 1
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0007 0.2352
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0095 0.2723
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0023 0.003 0.1318
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0012 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0203
Schistosoma mansoni ap endonuclease 0.0023 0.0029 0.1274
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0007 0.2352
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0087 0.2478
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0029 0.0832
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0023 0.003 0.0861
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0041 0.0041
Entamoeba histolytica serine acetyltransferase 1 0.0023 0.003 0.134
Entamoeba histolytica ankyrin, putative 0.0023 0.003 0.134
Echinococcus multilocularis protein patched 0.0051 0.0087 0.0439
Wolbachia endosymbiont of Brugia malayi carbonic anhydrase 0.0023 0.003 0.0023
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0087 0.0439
Brugia malayi CHE-14 protein 0.0051 0.0087 0.2478
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0007 0.0817
Schistosoma mansoni dynactin subunit P25 0.0023 0.003 0.1318
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0071 0.0361
Plasmodium vivax hypothetical protein, conserved 0.0023 0.003 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0755
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0029 0.0041 0.1176
Mycobacterium tuberculosis Possible transferase 0.0023 0.003 0.003
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0041 1
Entamoeba histolytica acetyltransferase, putative 0.0023 0.003 0.134
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0087 0.2478
Entamoeba histolytica acetyltransferase, putative 0.0023 0.003 0.134
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0007 0.0203
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0007 0.0203
Onchocerca volvulus 0.0029 0.0041 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.003 0.003
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0023 0.003 0.0153
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0203
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0095 0.4169
Schistosoma mansoni gdp-mannose pyrophosphorylase b isoform 2 0.0023 0.003 0.1318
Schistosoma mansoni topbp1 0.0012 0.0007 0.031
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0041 0.183
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0029 0.9661
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0087 1
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0023 0.003 0.3474
Schistosoma mansoni topbp1 0.0012 0.0007 0.031
Toxoplasma gondii hypothetical protein 0.0023 0.003 0.0166
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0023 0.003 0.0153
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0029 0.9557
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0071 0.2037
Echinococcus granulosus muscleblind protein 0.018 0.0351 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0095 0.2723
Echinococcus multilocularis mannose 1 phosphate guanyltransferase 0.0023 0.003 0.0153
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0041 0.0041
Entamoeba histolytica acetyltransferase, putative 0.0023 0.003 0.134
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0029 0.9661
Leishmania major GDP-mannose pyrophosphorylase 0.0023 0.003 0.7321
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0007 0.2352
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0007 0.0315
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0861
Brugia malayi GDP-mannose pyrophosphorylase B 0.0023 0.003 0.0861
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0007 0.0817
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0023 0.003 0.003
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0029 0.0022
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0023 0.003 1
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0007 0.2352
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0007 0.2352
Mycobacterium ulcerans hypothetical protein 0.0029 0.0041 0.0041
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.4914 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0041 0.1176
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.4914 1 1
Brugia malayi hypothetical protein 0.0012 0.0007 0.0203
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.003 1
Toxoplasma gondii GDP-D-mannose pyrophosphorylase 0.0023 0.003 0.0166
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.3145
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0026 0.8771
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0041 0.0041
Brugia malayi hypothetical protein 0.0043 0.0071 0.2037
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0007 0.0203
Brugia malayi hypothetical protein 0.0023 0.003 0.0861
Trypanosoma cruzi Translation initiation factor eIF-2B subunit epsilon, putative 0.0023 0.003 1
Plasmodium vivax mannose-1-phosphate guanyltransferase, putative 0.0023 0.003 1
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0329 0.9391
Entamoeba histolytica maltose O-acetyltransferase, putative 0.0023 0.003 0.134
Entamoeba histolytica translation initiation factor eIF-2B epsilon subunit, putative 0.0023 0.003 0.134
Loa Loa (eye worm) nucleotidyl transferase 0.0023 0.003 0.0861
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0755
Brugia malayi DKFZp564C0469 protein 0.0012 0.0007 0.0203
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0041 0.0041
Echinococcus multilocularis nibrin 0.0012 0.0007 0.0036
Leishmania major serine acetyltransferase 0.0023 0.003 0.7321
Mycobacterium ulcerans d-alpha-D-mannose-1-phosphate guanylyltransferase ManB 0.0023 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0203
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0029 0.9661
Echinococcus multilocularis muscleblind protein 0.018 0.0351 0.1771
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0029 0.0147
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0225 0.6424
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0026 0.0026
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0041 0.1176
Leishmania major hypothetical protein, conserved 0.0023 0.003 0.7321
Schistosoma mansoni hypothetical protein 0.0049 0.0083 0.363
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0007 0.0817
Loa Loa (eye worm) hypothetical protein 0.0029 0.0041 0.1176
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.003 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0203
Entamoeba histolytica acetyltransferase, putative 0.0023 0.003 0.134
Entamoeba histolytica hypothetical protein 0.0043 0.0071 0.3171
Schistosoma mansoni hypothetical protein 0.0049 0.0083 0.363
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0755
Echinococcus multilocularis dynactin 5 p25 0.0023 0.003 0.0153
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0095 0.2723
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0095 0.2723
Treponema pallidum licC protein (licC) 0.0901 0.182 1
Loa Loa (eye worm) hypothetical protein 0.018 0.0351 1
Brugia malayi Nucleotidyl transferase family protein 0.0023 0.003 0.0861
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0041 0.1176
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0023 0.003 0.0861
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0755
Trichomonas vaginalis mannose-1-phosphate guanyltransferase, putative 0.0023 0.003 0.3474
Trypanosoma cruzi serine acetyltransferase, putative 0.0023 0.003 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0007 0.0817
Entamoeba histolytica hypothetical protein 0.0043 0.0071 0.3171
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0007 0.0817
Mycobacterium ulcerans hypothetical protein 0.0901 0.182 0.182
Plasmodium falciparum mannose-1-phosphate guanyltransferase, putative 0.0023 0.003 1
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0007 0.0036
Toxoplasma gondii exonuclease III APE 0.0023 0.0029 0.016
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0007 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.003 1
Mycobacterium leprae PROBABLE SERINE ACETYLTRANSFERASE CYSE (SAT) 0.0023 0.003 0.003
Mycobacterium tuberculosis Conserved hypothetical protein 0.0901 0.182 0.182
Entamoeba histolytica acetyltransferase, putative 0.0023 0.003 0.134
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.003 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0071 0.312
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.003 1
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0029 0.0832
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0029 0.7073
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0901 0.182 0.182
Schistosoma mansoni DNA ligase IV 0.0012 0.0007 0.031
Entamoeba histolytica hypothetical protein 0.0012 0.0007 0.0315
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.003 1
Trypanosoma cruzi serine acetyltransferase, putative 0.0023 0.003 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0007 0.0817
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0041 0.183
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0225 1
Schistosoma mansoni hypothetical protein 0.0043 0.0071 0.312
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0901 0.182 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0029 0.3357
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0041 0.0041
Mycobacterium leprae POSSIBLE TRANSFERASE 0.0023 0.003 0.003
Echinococcus multilocularis protein dispatched 1 0.0058 0.0102 0.0513
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0024
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.003 0.003
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0041 0.0041
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0012 0.0007 0.0007
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0041 0.0041
Plasmodium falciparum liver specific protein 2, putative 0.0023 0.003 1
Schistosoma mansoni hypothetical protein 0.0049 0.0083 0.363
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0007 0.0817
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0203
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0023 0.003 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0041 0.0041
Echinococcus multilocularis muscleblind protein 1 0.018 0.0351 0.1771
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0026 0.8771
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0007 0.2352
Plasmodium vivax dynactin subunit 5, putative 0.0023 0.003 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.3109 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 2.9081 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.4591 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (binding) 19.9526 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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