Detailed information for compound 1411796

Basic information

Technical information
  • TDR Targets ID: 1411796
  • Name: 2-[2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]eth yl]isoindole-1,3-dione
  • MW: 304.387 | Formula: C14H12N2O2S2
  • H donors: 0 H acceptors: 3 LogP: 2.87 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1csc(n1)SCCN1C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C14H12N2O2S2/c1-9-8-20-14(15-9)19-7-6-16-12(17)10-4-2-3-5-11(10)13(16)18/h2-5,8H,6-7H2,1H3
  • InChiKey: ISAUGXWKBPULRV-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[2-(4-methylthiazol-2-yl)sulfanylethyl]isoindoline-1,3-dione
  • 2-[2-[(4-methyl-2-thiazolyl)thio]ethyl]isoindoline-1,3-dione
  • 2-[2-[(4-methylthiazol-2-yl)thio]ethyl]isoindoline-1,3-quinone
  • ZINC03413792
  • MLS000098436
  • SMR000065182
  • T5420043

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica acetyltransferase, putative 0.0023 0.003 0.134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0095 0.4169
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0861
Echinococcus granulosus nibrin 0.0012 0.0007 0.0203
Schistosoma mansoni hypothetical protein 0.0049 0.0083 0.363
Brugia malayi hypothetical protein 0.0023 0.003 0.0861
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0041 0.0041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0095 0.0482
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0029 0.3357
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0007 0.2352
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0023 0.003 0.003
Echinococcus multilocularis expressed conserved protein 0.0112 0.0211 0.1064
Mycobacterium ulcerans hypothetical protein 0.0901 0.182 0.182
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0029 0.0122
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.0023 0.003 0.134
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0023 0.003 0.1318
Entamoeba histolytica hypothetical protein 0.0043 0.0071 0.3171
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0861
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.003 0.3474
Brugia malayi Muscleblind-like protein 0.018 0.0351 1
Brugia malayi CHE-14 protein 0.0051 0.0087 0.2478
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0029 0.9661
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0026 0.8393
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0225 0.1138
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0755
Loa Loa (eye worm) nucleotidyl transferase 0.0023 0.003 0.0861
Loa Loa (eye worm) hypothetical protein 0.018 0.0351 1
Plasmodium vivax hypothetical protein, conserved 0.0023 0.003 1
Schistosoma mansoni glucosamine-1-phosphate N-acetyltransferase 0.0023 0.003 0.1318
Loa Loa (eye worm) hypothetical protein 0.0029 0.0041 0.1176
Schistosoma mansoni dynactin subunit P25 0.0023 0.003 0.1318
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.003 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0029 0.0832
Schistosoma mansoni mannose-1-phosphate guanyltransferase 0.0023 0.003 0.1318
Mycobacterium ulcerans transferase 0.0023 0.003 0.003
Toxoplasma gondii GDP-D-mannose pyrophosphorylase 0.0023 0.003 0.0166
Wolbachia endosymbiont of Brugia malayi carbonic anhydrase 0.0023 0.003 0.0023
Echinococcus multilocularis muscleblind protein 1 0.018 0.0351 0.1771
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0329 0.1664
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0007 0.0203
Entamoeba histolytica hypothetical protein 0.0043 0.0071 0.3171
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0023 0.003 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0087 0.0439
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.003 1
Brugia malayi GDP-mannose pyrophosphorylase B 0.0023 0.003 0.0861
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0087 1
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0007 0.2352
Plasmodium vivax dynactin subunit 5, putative 0.0023 0.003 1
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0023 0.003 0.0153
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0071 0.0361
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0755
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0041 0.0041
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0023 0.003 0.0861
Trypanosoma brucei nucleotidyl transferase, putative 0.0023 0.003 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0071 0.312
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.003 1
Entamoeba histolytica serine acetyltransferase 1 0.0023 0.003 0.134
Schistosoma mansoni ap endonuclease 0.0023 0.0029 0.1274
Brugia malayi eIF4-gamma/eIF5/eIF2-epsilon family protein 0.0023 0.003 0.0861
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0029 0.9661
Onchocerca volvulus 0.0029 0.0041 1
Schistosoma mansoni hypothetical protein 0.0049 0.0083 0.363
Entamoeba histolytica acetyltransferase, putative 0.0023 0.003 0.134
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0007 0.0039
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0029 0.9557
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0007 0.2352
Mycobacterium ulcerans hypothetical protein 0.0023 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0041 0.1176
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.003 1
Brugia malayi hypothetical protein 0.0012 0.0007 0.0203
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.1979 1
Brugia malayi topoisomerase 0.0012 0.0007 0.0203
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0007 0.0203
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0041 0.0041
Brugia malayi hypothetical protein 0.0023 0.003 0.0861
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0041 1
Entamoeba histolytica acetyltransferase, putative 0.0023 0.003 0.134
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0007 0.0817
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0007 0.2352
Entamoeba histolytica ankyrin, putative 0.0023 0.003 0.134
Schistosoma mansoni hypothetical protein 0.0023 0.003 0.1318
Loa Loa (eye worm) hypothetical protein 0.0119 0.0225 0.6424
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0225 0.6424
Schistosoma mansoni patched 1 0.0051 0.0087 0.3794
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0087 0.2478
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0007 0.031
Leishmania major GDP-mannose pyrophosphorylase 0.0023 0.003 0.7321
Echinococcus granulosus dynactin 5 p25 0.0023 0.003 0.0861
Entamoeba histolytica hypothetical protein 0.0012 0.0007 0.0315
Echinococcus granulosus mannose 1 phosphate guanyltransferase 0.0023 0.003 0.0861
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0007 0.2352
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0007 0.0817
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.4914 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0041 0.183
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0041 1
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0007 0.0039
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0007 0.2352
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0023 0.003 0.3474
Schistosoma mansoni hypothetical protein 0.0049 0.0083 0.363
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0029 0.0147
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0023 0.003 0.0861
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0023 0.003 0.0153
Plasmodium vivax mannose-1-phosphate guanyltransferase, putative 0.0023 0.003 1
Trichomonas vaginalis glucose-1-phosphate thymidylyltransferase, putative 0.0023 0.003 0.3474
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.003 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0041 0.0041
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0329 0.9391
Brugia malayi zgc:92842 0.0023 0.003 0.0861
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0024
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0007 0.0203
Loa Loa (eye worm) hypothetical protein 0.0029 0.0041 0.1176
Plasmodium falciparum liver specific protein 2, putative 0.0023 0.003 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0041 0.1176
Giardia lamblia Translation initiation factor 0.0023 0.003 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0041 0.1176
Leishmania major serine acetyltransferase 0.0023 0.003 0.7321
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0023 0.003 0.3474
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0012 0.0007 0.0007
Brugia malayi hypothetical protein 0.0023 0.003 0.0861
Trichomonas vaginalis mannose-1-phosphate guanyltransferase, putative 0.0023 0.003 0.3474
Loa Loa (eye worm) hypothetical protein 0.0051 0.0087 0.2478
Entamoeba histolytica serine acetyltransferase, putative 0.0023 0.003 0.134
Echinococcus multilocularis dynactin 5 p25 0.0023 0.003 0.0153
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0041 0.183
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0041 0.183
Brugia malayi Nucleotidyl transferase family protein 0.0023 0.003 0.0861
Entamoeba histolytica acetyltransferase, putative 0.0023 0.003 0.134
Echinococcus multilocularis protein dispatched 1 0.0058 0.0102 0.0513
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0029 0.9661
Mycobacterium ulcerans d-alpha-D-mannose-1-phosphate guanylyltransferase ManB 0.0023 0.003 0.003
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0023 0.003 0.0861
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0007 0.0817
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0007 0.0315
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.003 1
Schistosoma mansoni gdp-mannose pyrophosphorylase b isoform 2 0.0023 0.003 0.1318
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0024
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0041 0.0041
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.4914 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0755
Chlamydia trachomatis UDP-3-O-acylglucosamine N-acyltransferase 0.0023 0.003 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0007 0.0817
Brugia malayi hypothetical protein 0.0012 0.0007 0.0203
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0024 0.0033 0.0033
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0029 0.7073
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0041 0.0041
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0041 1
Schistosoma mansoni ap endonuclease 0.0023 0.0029 0.1274
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0026 0.8771
Toxoplasma gondii eukaryotic initiation factor-2B, epsilon subunit, putative 0.0023 0.003 0.0166
Loa Loa (eye worm) hypothetical protein 0.018 0.0351 1
Chlamydia trachomatis acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase 0.0023 0.003 1
Plasmodium falciparum mannose-1-phosphate guanyltransferase, putative 0.0023 0.003 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0029 0.0022
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0023 0.003 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0026 0.8771
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0024
Schistosoma mansoni topbp1 0.0012 0.0007 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0007 0.0817
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0095 0.4169
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0007 0.2352
Trypanosoma cruzi hypothetical protein 0.0023 0.003 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0041 0.1176
Echinococcus granulosus expressed conserved protein 0.0112 0.0211 0.6005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0203
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0225 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0225 0.6424
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0095 0.0482
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0203
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.003 0.003
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0901 0.182 0.182
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0029 0.3357
Entamoeba histolytica acetyltransferase, putative 0.0023 0.003 0.134
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0087 0.2478
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0007 0.0817
Mycobacterium tuberculosis Conserved hypothetical protein 0.0901 0.182 0.182
Entamoeba histolytica hypothetical protein 0.0043 0.0071 0.3171
Entamoeba histolytica hypothetical protein 0.0043 0.0071 0.3171
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0095 0.2723
Schistosoma mansoni hypothetical protein 0.0043 0.0071 0.312
Trypanosoma brucei GDP-mannose pyrophosphorylase 0.0023 0.003 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0026 0.0026
Treponema pallidum licC protein (licC) 0.0901 0.182 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0007 0.0817
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0203
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0095 0.4169
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0901 0.182 1
Toxoplasma gondii eukaryotic initiation factor 2B epsilon subunit, putative 0.0023 0.003 0.0166
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0203
Mycobacterium tuberculosis Conserved hypothetical protein 0.0901 0.182 0.182
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0029 0.9661
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0755
Echinococcus granulosus muscleblind protein 0.018 0.0351 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0041 0.0041
Entamoeba histolytica serine acetyltransferase 1 0.0023 0.003 0.134
Toxoplasma gondii exonuclease III APE 0.0023 0.0029 0.016
Mycobacterium tuberculosis Possible transferase 0.0023 0.003 0.003
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0007 0.0036
Mycobacterium leprae POSSIBLE TRANSFERASE 0.0023 0.003 0.003
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0041 0.0041
Plasmodium falciparum dynactin subunit 5, putative 0.0023 0.003 1
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.003 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0041 0.0041
Entamoeba histolytica acetyltransferase, putative 0.0023 0.003 0.134
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0229 1
Trichomonas vaginalis sugar-1-phosphate guanyl transferase, putative 0.0023 0.003 0.3474
Echinococcus multilocularis nibrin 0.0012 0.0007 0.0036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0095 0.2723
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.0023 0.003 0.134
Trypanosoma cruzi Translation initiation factor eIF-2B subunit epsilon, putative 0.0023 0.003 1
Schistosoma mansoni topbp1 0.0012 0.0007 0.031
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0007 0.0817
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0041 0.0041
Leishmania major hypothetical protein, conserved 0.0023 0.003 0.7321
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0087 0.2478
Brugia malayi DKFZp564C0469 protein 0.0012 0.0007 0.0203
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0095 0.2723
Mycobacterium tuberculosis Possible siderophore-binding protein 0.0023 0.003 0.003
Brugia malayi hypothetical protein 0.0043 0.0071 0.2037
Mycobacterium leprae PROBABLE SERINE ACETYLTRANSFERASE CYSE (SAT) 0.0023 0.003 0.003
Echinococcus multilocularis protein patched 0.0051 0.0087 0.0439
Echinococcus multilocularis mannose 1 phosphate guanyltransferase 0.0023 0.003 0.0153
Echinococcus multilocularis muscleblind protein 0.018 0.0351 0.1771
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0026 0.0026
Entamoeba histolytica maltose O-acetyltransferase, putative 0.0023 0.003 0.134
Onchocerca volvulus 0.0012 0.0007 0.1722
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.4914 1 1
Mycobacterium ulcerans serine acetyltransferase CysE 0.0023 0.003 0.003
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0029 0.1295
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.003 1
Toxoplasma gondii hypothetical protein 0.0023 0.003 0.0166
Leishmania major hypothetical protein, conserved 0.0023 0.003 0.7321
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0023 0.003 0.0861
Schistosoma mansoni DNA ligase IV 0.0012 0.0007 0.031
Trypanosoma cruzi serine acetyltransferase, putative 0.0023 0.003 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0029 0.0029
Entamoeba histolytica maltose O-acetyltransferase, putative 0.0023 0.003 0.134
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0029 0.0832
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0007 0.0817
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0029 0.0029
Entamoeba histolytica translation initiation factor eIF-2B epsilon subunit, putative 0.0023 0.003 0.134
Wolbachia endosymbiont of Brugia malayi 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 0.0023 0.003 0.0023
Mycobacterium ulcerans hypothetical protein 0.0029 0.0041 0.0041
Leishmania major hypothetical protein, conserved 0.0023 0.003 0.7321
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0012 0.0007 0.0007
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0041 0.0041
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0007 0.0817
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0029 0.0832
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0095 0.2723
Trypanosoma cruzi serine acetyltransferase, putative 0.0023 0.003 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0755
Loa Loa (eye worm) dynactin 5 0.0023 0.003 0.0861
Mycobacterium ulcerans hypothetical protein 0.0901 0.182 0.182
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0203
Brugia malayi hypothetical protein 0.0023 0.003 0.0861
Schistosoma mansoni hypothetical protein 0.0049 0.0083 0.363
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0071 0.2037
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.3145
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0029 0.9661

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.3109 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 2.9081 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.4591 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (binding) 19.9526 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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