Detailed information for compound 1412162

Basic information

Technical information
  • TDR Targets ID: 1412162
  • Name: N-(3,5-dimethylphenyl)-5-methyl-1-[[5-methyl- 2-(3,4,5-trimethoxyphenyl)-1,3-oxazol-4-yl]me thyl]triazole-4-carboxamide
  • MW: 491.539 | Formula: C26H29N5O5
  • H donors: 1 H acceptors: 4 LogP: 4.01 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(OC)cc(cc1OC)c1nc(c(o1)C)Cn1nnc(c1C)C(=O)Nc1cc(C)cc(c1)C
  • InChi: 1S/C26H29N5O5/c1-14-8-15(2)10-19(9-14)27-25(32)23-16(3)31(30-29-23)13-20-17(4)36-26(28-20)18-11-21(33-5)24(35-7)22(12-18)34-6/h8-12H,13H2,1-7H3,(H,27,32)
  • InChiKey: CZVRVFAIHRCIFQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(3,5-dimethylphenyl)-5-methyl-1-[[5-methyl-2-(3,4,5-trimethoxyphenyl)oxazol-4-yl]methyl]triazole-4-carboxamide
  • N-(3,5-dimethylphenyl)-5-methyl-1-[[5-methyl-2-(3,4,5-trimethoxyphenyl)-4-oxazolyl]methyl]-4-triazolecarboxamide
  • N-(3,5-dimethylphenyl)-5-methyl-1-[[5-methyl-2-(3,4,5-trimethoxyphenyl)-1,3-oxazol-4-yl]methyl]-1,2,3-triazole-4-carboxamide
  • C200-5479
  • NCGC00105459-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0108 0.1479 0.1476
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0108 0.1479 0.1479
Brugia malayi isocitrate dehydrogenase 0.0017 0.0003 0.0003
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0053 0.0341
Onchocerca volvulus 0.0164 0.2383 1
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0633 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0083 0.0081
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0983 0.0981
Brugia malayi Bromodomain containing protein 0.0046 0.0476 0.0476
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0083 0.0081
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0059 0.0056
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0867 0.0864
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0059
Toxoplasma gondii exonuclease III APE 0.0022 0.0083 0.0081
Loa Loa (eye worm) hypothetical protein 0.0046 0.0477 0.0477
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0078 0.0983 0.0983
Schistosoma mansoni inositol monophosphatase 0.0042 0.041 0.0407
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0708 0.0705
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0895 0.0893
Mycobacterium ulcerans hypothetical protein 0.0037 0.0332 0.7637
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0332 0.0915
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0059 0.0056
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0078 0.0983 0.0981
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0108 0.1479 0.1479
Brugia malayi hypothetical protein 0.0164 0.2383 0.2383
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0235 0.3546 0.3544
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0633 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0056 0.0635 0.0632
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0235 0.3546 0.3544
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0053 0.005
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0239 0.0239
Schistosoma mansoni lamin 0.0032 0.0239 0.0236
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0059 0.0056
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0053 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0975 0.0973
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0083 0.244
Echinococcus multilocularis zinc finger protein 0.0024 0.0108 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0975 0.0973
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0633 1 1
Schistosoma mansoni carbonic anhydrase-related 0.0108 0.1479 0.1476
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0332 0.7837
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0332 0.033
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.041 0.0407
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0078 0.0983 0.0983
Mycobacterium tuberculosis Conserved protein 0.0037 0.0332 0.0915
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.041 1
Leishmania major carbonic anhydrase-like protein 0.02 0.2964 0.2962
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.041 0.0407
Echinococcus granulosus zinc finger protein 0.0024 0.0108 0.0106
Brugia malayi Bromodomain containing protein 0.0091 0.1195 0.1195
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0108 0.1479 0.1479
Leishmania major hypothetical protein, conserved 0.0018 0.0025 0.0022
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0332 0.0915
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0235 0.3546 0.3544
Brugia malayi Inositol-1 0.0042 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0108 0.1479 0.1479
Echinococcus multilocularis cysteine protease 0.002 0.0053 0.005
Loa Loa (eye worm) fibroinase 0.002 0.0053 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0975 0.0973
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0332 0.033
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0975 0.0973
Loa Loa (eye worm) hypothetical protein 0.0108 0.1479 0.1479
Loa Loa (eye worm) cysteine protease 0.002 0.0053 0.0053
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0129 0.0129
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0083 0.5
Echinococcus granulosus carbonic anhydrase II 0.02 0.2964 0.2962
Loa Loa (eye worm) hypothetical protein 0.0032 0.0239 0.0239
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0078 0.0983 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0523 0.0523
Brugia malayi beta-lactamase family protein 0.0037 0.0332 0.0332
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0053
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0053 0.005
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0083 0.0847
Echinococcus multilocularis musashi 0.0032 0.0239 0.0236
Echinococcus multilocularis cysteine protease 0.002 0.0053 0.005
Loa Loa (eye worm) hypothetical protein 0.0037 0.0332 0.0332
Leishmania major cathepsin L-like protease 0.002 0.0053 0.005
Echinococcus granulosus intermediate filament protein 0.0032 0.0239 0.0236
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.041 0.0407
Brugia malayi PHD-finger family protein 0.003 0.0213 0.0213
Echinococcus multilocularis carbonic anhydrase 0.0108 0.1479 0.1476
Leishmania major cathepsin L-like protease 0.002 0.0053 0.005
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0083 0.0083
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0167 0.0164
Echinococcus granulosus lamin 0.0032 0.0239 0.0236
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0332 0.7837
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0332 0.0915
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.041 1
Trypanosoma brucei carbonic anhydrase-like protein 0.02 0.2964 0.2962
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0108 0.1479 0.1479
Loa Loa (eye worm) carbonic anhydrase 3 0.02 0.2964 0.2964
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0633 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0975 0.0973
Loa Loa (eye worm) hypothetical protein 0.0052 0.0561 0.0561
Schistosoma mansoni ap endonuclease 0.0022 0.0083 0.0081
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0453 0.045
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0239 0.0239
Schistosoma mansoni lamin 0.0032 0.0239 0.0236
Leishmania major cathepsin L-like protease 0.0077 0.0975 0.0973
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.02 0.2964 0.2962
Brugia malayi Cathepsin L-like precursor 0.002 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0037 0.0332 0.0332
Loa Loa (eye worm) inositol-1 0.0042 0.041 0.041
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.041 1
Plasmodium vivax vivapain-2 0.002 0.0053 0.1525
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0083 0.0081
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0332 0.033
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0053 0.0053
Brugia malayi Cathepsin L-like precursor 0.002 0.0053 0.0053
Leishmania major cathepsin L-like protease 0.002 0.0053 0.005
Toxoplasma gondii ABC1 family protein 0.0037 0.0332 0.033
Brugia malayi Cytochrome P450 family protein 0.0024 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0037 0.0332 0.0332
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0167 0.0164
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0332 0.7837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0975 0.0973
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0332 0.033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0059 0.0056
Toxoplasma gondii fructose-bisphospatase II 0.0633 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0108 0.1479 0.1479
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0059 0.0056
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0108 0.1479 0.1479
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0018 0.0025 0.0022
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0059 0.0056
Schistosoma mansoni bromodomain containing protein 0.0076 0.0965 0.0963
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0633 1 1
Toxoplasma gondii hypothetical protein 0.0108 0.1479 0.1476
Loa Loa (eye worm) hypothetical protein 0.0037 0.0332 0.0332
Echinococcus multilocularis geminin 0.0199 0.2955 0.2953
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0059 0.0056
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0332 0.7837
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0118 0.0118
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.041 0.0407
Leishmania major cathepsin L-like protease 0.002 0.0053 0.005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0083 0.0081
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0053 0.005
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0083 0.5
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0235 0.3546 0.3544
Onchocerca volvulus 0.0037 0.0332 0.12
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0332 0.033
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0332 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0053 0.0341
Echinococcus granulosus geminin 0.0199 0.2955 0.2953
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0338 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0053 0.0053
Schistosoma mansoni zinc finger protein 0.0018 0.0025 0.0022
Echinococcus granulosus lamin dm0 0.0032 0.0239 0.0236
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0975 0.0973
Leishmania major 0.0633 1 1
Schistosoma mansoni zinc finger protein 0.0024 0.0108 0.0106
Brugia malayi beta-lactamase family protein 0.0037 0.0332 0.0332
Loa Loa (eye worm) hypothetical protein 0.0037 0.0332 0.0332
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0083 0.0223
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0453 0.045
Schistosoma mansoni hypothetical protein 0.0199 0.2955 0.2953
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0332 0.0332
Onchocerca volvulus 0.0032 0.0239 0.0797
Echinococcus multilocularis lamin 0.0032 0.0239 0.0236
Brugia malayi intermediate filament protein 0.0032 0.0239 0.0239
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0078 0.0983 0.0981
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0429 0.0427
Mycobacterium ulcerans lipase LipD 0.0037 0.0332 0.7637
Schistosoma mansoni carbonic anhydrase-related 0.0108 0.1479 0.1476
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0053 0.0341
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0975 0.0973
Echinococcus multilocularis carbonic anhydrase 0.0108 0.1479 0.1476
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0975 0.0973
Schistosoma mansoni ap endonuclease 0.0022 0.0083 0.0081
Trichomonas vaginalis esterase, putative 0.0037 0.0332 0.7837
Schistosoma mansoni carbonic anhydrase 0.0108 0.1479 0.1476
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0338 0.093
Plasmodium vivax vivapain-2 0.002 0.0053 0.1525
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0239 0.0239
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0053 0.005
Leishmania major cathepsin L-like protease 0.0077 0.0975 0.0973
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0332 0.0915
Echinococcus granulosus carbonic anhydrase 0.0108 0.1479 0.1476
Toxoplasma gondii fructose-bisphospatase I 0.0235 0.3546 0.3544
Echinococcus multilocularis carbonic anhydrase 0.0108 0.1479 0.1476
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0332 0.7837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0975 0.0973
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0975 0.0973
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0053 0.005
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.041 0.0407
Echinococcus granulosus carbonic anhydrase 0.0108 0.1479 0.1476
Leishmania major cathepsin L-like protease 0.0077 0.0975 0.0973
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.041 1
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0975 0.0973
Onchocerca volvulus 0.0037 0.0332 0.12
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.02 0.2964 0.2964
Loa Loa (eye worm) beta-lactamase 0.0037 0.0332 0.0332
Toxoplasma gondii cathepsin CPL 0.002 0.0053 0.005
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.041 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0053 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0975 0.0973
Echinococcus multilocularis lamin dm0 0.0032 0.0239 0.0236
Schistosoma mansoni hypothetical protein 0.0025 0.0129 0.0127
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.041 0.0407
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0332 0.0915
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0083 0.0081
Loa Loa (eye worm) ctsf protein 0.002 0.0053 0.0053
Trypanosoma cruzi ISWI complex protein 0.0018 0.0025 0.0022
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.0229
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0167 0.0164
Loa Loa (eye worm) hypothetical protein 0.0037 0.0332 0.0332
Leishmania major cysteine peptidase A (CPA) 0.002 0.0053 0.005
Leishmania major cathepsin L-like protease 0.002 0.0053 0.005
Echinococcus multilocularis carbonic anhydrase II 0.02 0.2964 0.2962
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0053 0.005
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.02 0.2964 0.2962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0975 0.0973
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0332 0.0915
Onchocerca volvulus 0.0037 0.0332 0.12
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0078 0.0983 0.0981
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0975 0.0973
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.02 0.2964 0.2962
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0332 0.033
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0083 0.0083
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0053 0.005
Trypanosoma brucei ISWI complex protein 0.0018 0.0025 0.0022
Brugia malayi Cathepsin L-like precursor 0.002 0.0053 0.0053
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0332 0.7637
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0003 0.0003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0083 0.0081
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0059 0.0056
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0078 0.0983 0.0981
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0083 0.0847
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0332 0.0332
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0895 0.0893
Mycobacterium ulcerans beta-lactamase 0.0037 0.0332 0.7637
Echinococcus granulosus carbonic anhydrase 0.0108 0.1479 0.1476
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0332 0.033
Trypanosoma cruzi ISWI complex protein 0.0018 0.0025 0.0022
Schistosoma mansoni carbonic anhydrase-related 0.0108 0.1479 0.1476
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0332 0.7637
Schistosoma mansoni hypothetical protein 0.0199 0.2955 0.2953
Echinococcus granulosus cathepsin l1 0.002 0.0053 0.005
Plasmodium falciparum carbonic anhydrase 0.0108 0.1479 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.2383 0.2383
Leishmania major hypothetical protein, conserved 0.0037 0.0332 0.033
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.041 0.3836
Loa Loa (eye worm) hypothetical protein 0.0085 0.1111 0.1111
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.3608 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0332 0.0915
Mycobacterium tuberculosis Conserved protein 0.0037 0.0332 0.0915
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0633 1 1
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0071 0.0071
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0633 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0053 0.005
Brugia malayi Cathepsin L-like precursor 0.002 0.0053 0.0053
Brugia malayi beta-lactamase 0.0037 0.0332 0.0332
Onchocerca volvulus 0.0032 0.0239 0.0797
Loa Loa (eye worm) hypothetical protein 0.0108 0.1479 0.1479
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0429 0.0427
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.02 0.2964 0.2964
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0983 0.0981
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0053 0.0053
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0332 0.0915
Schistosoma mansoni intermediate filament proteins 0.0032 0.0239 0.0236
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.02 0.2964 0.2962
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0083 0.0325
Schistosoma mansoni inositol monophosphatase 0.0042 0.041 0.0407
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.041 0.0407
Brugia malayi Putative carbonic anhydrase 5 precursor 0.02 0.2964 0.2964
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0083 0.0545
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0983 0.0981

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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