Detailed information for compound 1414082

Basic information

Technical information
  • TDR Targets ID: 1414082
  • Name: 2-cyclohexyl-1-[3-[3-(4-pyrrolidin-1-ylsulfon ylphenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl ]ethanone
  • MW: 486.627 | Formula: C25H34N4O4S
  • H donors: 0 H acceptors: 5 LogP: 4.18 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCCC(C1)c1onc(n1)c1ccc(cc1)S(=O)(=O)N1CCCC1)CC1CCCCC1
  • InChi: 1S/C25H34N4O4S/c30-23(17-19-7-2-1-3-8-19)28-14-6-9-21(18-28)25-26-24(27-33-25)20-10-12-22(13-11-20)34(31,32)29-15-4-5-16-29/h10-13,19,21H,1-9,14-18H2
  • InChiKey: QXGIORGJKHSRIV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-cyclohexyl-1-[3-[3-(4-pyrrolidin-1-ylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-piperidyl]ethanone
  • 2-cyclohexyl-1-[3-[3-(4-1-pyrrolidinylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]ethanone
  • ASN 06937031
  • 2-Cyclohexyl-1-(3-{3-[4-(pyrrolidine-1-sulfonyl)-phenyl]-[1,2,4]oxadiazol-5-yl}-piperidin-1-yl)-ethanone
  • MLS000067293
  • SMR000124754

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0109 0.0342 0.3985
Trypanosoma cruzi kinesin, putative 0.0112 0.0354 0.1335
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Entamoeba histolytica cysteine protease, putative 0.0066 0.0172 0.485
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.008 0.0226 0.0852
Entamoeba histolytica cysteine protease, putative 0.0037 0.0056 0.1569
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0048 0.0101 0.1178
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0027
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.0056 0.0056
Trypanosoma cruzi oligopeptidase b 0.0051 0.0113 0.0425
Leishmania major kinesin, putative 0.0112 0.0354 0.4124
Plasmodium falciparum cysteine proteinase falcipain 1 0.0066 0.0172 0.2047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.0342 0.3985
Echinococcus granulosus cathepsin L 0.0037 0.0056 0.0209
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.1178
Echinococcus granulosus calpain A 0.0449 0.1683 0.6342
Loa Loa (eye worm) fibroinase 0.0109 0.0342 0.0342
Trypanosoma brucei prolyl oligopeptidase, putative 0.0051 0.0113 0.1313
Toxoplasma gondii cathepsin B 0.024 0.0859 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.0027 0.0027
Entamoeba histolytica cysteine proteinase, putative 0.0066 0.0172 0.485
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.0381
Entamoeba histolytica cysteine proteinase, putative 0.0066 0.0172 0.485
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.1178
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0109 0.0342 0.0907
Trypanosoma brucei unspecified product 0.0023 0.0002 0.0027
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0002 0.0009
Entamoeba histolytica cysteine proteinase, putative 0.0109 0.0342 0.9662
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.1178
Trypanosoma brucei Calpain-like protein CALP1.3 0.0048 0.0101 0.1178
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0109 0.0342 0.0907
Echinococcus granulosus cathepsin b 0.0695 0.2654 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0037 0.0056 0.0892
Leishmania major cathepsin L-like protease 0.0109 0.0342 0.3985
Trypanosoma brucei cysteine peptidase, putative 0.0048 0.0101 0.1178
Schistosoma mansoni cathepsin F (C01 family) 0.0109 0.0342 0.0716
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.0342 0.3985
Entamoeba histolytica cysteine protease, putative 0.0066 0.0172 0.485
Entamoeba histolytica cysteine proteinase 1, putative 0.0066 0.0172 0.485
Entamoeba histolytica calpain family cysteine protease, putative 0.0048 0.0101 0.2856
Echinococcus multilocularis cysteine protease 0.0109 0.0342 0.0907
Trypanosoma brucei antigen, putative 0.0161 0.0545 0.6346
Brugia malayi fibroinase precursor 0.0037 0.0056 0.0056
Onchocerca volvulus 0.0109 0.0342 0.3572
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.1178
Trypanosoma brucei calpain, putative 0.0048 0.0101 0.1178
Echinococcus granulosus cathepsin L 0.0066 0.0172 0.0648
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0695 0.2654 0.5551
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0109 0.0342 0.3985
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.1178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0056 0.0647
Trypanosoma cruzi major cysteine proteinase, putative 0.0037 0.0056 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.0342 0.3985
Brugia malayi calpain family protein 1 0.0426 0.1594 0.1594
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0037 0.0056 0.0056
Trypanosoma brucei calpain-like protein, putative 0.0161 0.0545 0.6346
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.1178
Schistosoma mansoni calpain-2 (C02 family) 0.0048 0.0101 0.0212
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0048 0.0101 0.1178
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0695 0.2654 0.5551
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0161 0.0545 0.2054
Brugia malayi Papain family cysteine protease containing protein 0.0066 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0037 0.0056 0.0647
Entamoeba histolytica cysteine protease, putative 0.0066 0.0172 0.485
Schistosoma mansoni DNA polymerase eta 0.0023 0.0002 0.0005
Giardia lamblia Cathepsin L precursor 0.0037 0.0056 0.0647
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0056 0.0116
Plasmodium falciparum plasmepsin IX 0.0181 0.0624 1
Echinococcus granulosus cathepsin L cysteine protease 0.0066 0.0172 0.0648
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0129 0.042 0.042
Giardia lamblia Cathepsin B precursor 0.024 0.0859 1
Echinococcus granulosus calpain A 0.0161 0.0545 0.2054
Echinococcus multilocularis prolyl endopeptidase 0.0129 0.042 0.1111
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0161 0.0545 0.2054
Loa Loa (eye worm) cathepsin B 0.024 0.0859 0.0859
Brugia malayi Cathepsin L-like precursor 0.0109 0.0342 0.0342
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0066 0.0172 0.0359
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.1178
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0027
Echinococcus granulosus calpain 7 C02 family 0.0161 0.0545 0.2054
Brugia malayi calpain D 0.0048 0.0101 0.0101
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0051 0.0113 0.3037
Entamoeba histolytica cysteine proteinase, putative 0.008 0.0226 0.6381
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0128 0.0269
Brugia malayi calpain 5 0.0048 0.0101 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.0342 0.3985
Plasmodium vivax serine-repeat antigen (SERA) 0.0037 0.0056 0.0892
Schistosoma mansoni cathepsin s 0.0029 0.0027 0.0056
Brugia malayi calpain 5 0.0112 0.0354 0.0354
Giardia lamblia Cathepsin B precursor 0.0037 0.0056 0.0647
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0695 0.2654 0.2654
Loa Loa (eye worm) hypothetical protein 0.0314 0.1149 0.1149
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.0342 0.3985
Onchocerca volvulus Cathepsin L homolog 0.0109 0.0342 0.3572
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.008 0.0226 0.2632
Entamoeba histolytica hypothetical protein 0.0037 0.0056 0.1569
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0128 0.0484
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0128 0.034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0172 0.2
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0066 0.0172 0.0359
Schistosoma mansoni cathepsin F (C01 family) 0.0109 0.0342 0.0716
Echinococcus granulosus prolyl endopeptidase 0.0129 0.042 0.1581
Brugia malayi Papain family cysteine protease containing protein 0.0066 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0109 0.0342 0.3985
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0048 0.0101 0.0381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.0342 0.3985
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0066 0.0172 0.0648
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Echinococcus granulosus dna polymerase eta 0.0023 0.0002 0.0009
Entamoeba histolytica cysteine protease, putative 0.0109 0.0342 0.9662
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0037 0.0056 0.0892
Entamoeba histolytica cysteine proteinase, putative 0.0066 0.0172 0.485
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1234 0.4782 1
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0048 0.0101 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0101 0.1178
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0002 0.0009
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.2556 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0172 0.2
Echinococcus granulosus cysteine protease 0.0066 0.0172 0.0648
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0048 0.0101 0.0381
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0426 0.1594 0.1594
Onchocerca volvulus 0.0109 0.0342 0.3572
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0027
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0449 0.1682 0.3518
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0109 0.0342 0.0342
Brugia malayi Cathepsin L-like precursor 0.0029 0.0027 0.0027
Trichomonas vaginalis calpain, putative 0.0048 0.0101 0.1178
Giardia lamblia Cathepsin L precursor 0.0037 0.0056 0.0647
Brugia malayi Cathepsin L-like precursor 0.0109 0.0342 0.0342
Plasmodium vivax unspecified product 0.0066 0.0172 0.2756
Giardia lamblia Cathepsin L precursor 0.0037 0.0056 0.0647
Plasmodium vivax vivapain-2 0.0109 0.0342 0.5491
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0109 0.0342 0.3985
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.1178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0109 0.0342 0.3985
Echinococcus granulosus cathepsin l cysteine peptidase 0.0109 0.0342 0.129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.0342 0.3985
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0128 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0056 0.0647
Leishmania major cathepsin L-like protease 0.0109 0.0342 0.3985
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0002 0.0027
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0037 0.0056 0.0892
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0037 0.0056 0.0056
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0037 0.0056 0.0892
Echinococcus multilocularis cysteine protease 0.0109 0.0342 0.0907
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0056 0.0056
Schistosoma mansoni calpain-7 (C02 family) 0.0161 0.0545 0.114
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0048 0.0101 0.0381
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0037 0.0056 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0056 0.0647
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0056 0.0116
Entamoeba histolytica calpain large subunit domain III containing protein 0.0112 0.0354 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.024 0.0859 1
Entamoeba histolytica cysteine protease, putative 0.0066 0.0172 0.485
Onchocerca volvulus Cathepsin F homolog 0.0109 0.0342 0.3572
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0128 0.0484
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0056 0.0647
Echinococcus granulosus cathepsin b 0.0695 0.2654 1
Loa Loa (eye worm) calpain 0.0161 0.0545 0.0545
Brugia malayi Cathepsin L-like precursor 0.008 0.0226 0.0226
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.0381
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.1178
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0449 0.1682 0.3518
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.0381
Trypanosoma cruzi major cysteine proteinase, putative 0.0037 0.0056 0.0209
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.0381
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0048 0.0101 0.1178
Entamoeba histolytica cysteine protease, putative 0.0037 0.0056 0.1569
Entamoeba histolytica cysteine proteinase, putative 0.0109 0.0342 0.9662
Onchocerca volvulus 0.0266 0.0959 1
Giardia lamblia Cysteine protease 0.0037 0.0056 0.0647
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0002 0.0027
Leishmania major DNA polymerase kappa, putative 0.0023 0.0002 0.0027
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0048 0.0101 0.1178
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0128 0.0128
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0066 0.0172 0.0359
Schistosoma mansoni cathepsin C 0.0037 0.0056 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.0056 0.0647
Entamoeba histolytica cysteine protease, putative 0.0066 0.0172 0.485
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.0342 0.3985
Onchocerca volvulus Cathepsin L homolog 0.0037 0.0056 0.058
Entamoeba histolytica protein kinase, putative 0.0112 0.0354 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0027
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0051 0.0113 0.1313
Schistosoma mansoni cathepsin D (A01 family) 0.0207 0.0728 0.1522
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0056 0.0116
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0048 0.0101 0.1178
Trypanosoma cruzi cysteine protease, putative 0.0066 0.0172 0.0648
Schistosoma mansoni cathepsin B (C01 family) 0.0037 0.0056 0.0116
Trypanosoma brucei prolyl endopeptidase 0.0129 0.042 0.4883
Giardia lamblia Cathepsin B precursor 0.0037 0.0056 0.0647
Schistosoma mansoni hypothetical protein 0.0048 0.0101 0.0212
Giardia lamblia Cathepsin L precursor 0.0037 0.0056 0.0647
Loa Loa (eye worm) hypothetical protein 0.0048 0.0101 0.0101
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0027
Giardia lamblia Cathepsin L precursor 0.0037 0.0056 0.0647
Echinococcus granulosus dna polymerase kappa 0.0023 0.0002 0.0009
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0002 0.0027
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0056 0.0116
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.1178
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0037 0.0056 0.0116
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.0381
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0048 0.0101 0.1178
Trypanosoma cruzi cysteine proteinase, putative 0.0066 0.0172 0.0648
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.0381
Plasmodium vivax unspecified product 0.0029 0.0027 0.0427
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0128 0.0269
Leishmania major hypothetical protein, unknown function 0.0048 0.0101 0.1178
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0048 0.0101 0.1178
Leishmania major cathepsin L-like protease 0.0109 0.0342 0.3985
Entamoeba histolytica cysteine protease, putative 0.0066 0.0172 0.485
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.2115 0.5601
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.1178
Brugia malayi Cathepsin L-like precursor 0.0109 0.0342 0.0342
Trypanosoma cruzi cysteine peptidase, putative 0.0109 0.0342 0.129
Echinococcus multilocularis cathepsin L cysteine protease 0.0109 0.0342 0.0907
Giardia lamblia Encystation-specific protease 0.0037 0.0056 0.0647
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.3776 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0056 0.0647
Brugia malayi cathepsin L-like cysteine proteinase 0.0037 0.0056 0.0056
Loa Loa (eye worm) calpain 5 0.0112 0.0354 0.0354
Trichomonas vaginalis hypothetical protein 0.0048 0.0101 0.1178
Brugia malayi calpain family protein 1 0.0426 0.1594 0.1594
Brugia malayi prolyl oligopeptidase family protein 0.0129 0.042 0.042
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.024 0.0859 0.3237
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0048 0.0101 0.0381
Giardia lamblia Cathepsin L precursor 0.0037 0.0056 0.0647
Loa Loa (eye worm) hypothetical protein 0.0109 0.0342 0.0342
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0051 0.0113 0.0425
Trypanosoma cruzi cysteine peptidase, putative 0.0109 0.0342 0.129
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0172 0.0648
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0056 0.0647
Trypanosoma brucei Calpain-like protein 1.1 0.0048 0.0101 0.1178
Trypanosoma cruzi kinesin, putative 0.0112 0.0354 0.1335
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0002 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.0342 0.3985
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0048 0.0101 0.0381
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0002 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.0342 0.3985
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0027
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0224 0.0796 0.1665
Brugia malayi MH2 domain containing protein 0.0144 0.0479 0.0479
Trypanosoma brucei oligopeptidase b 0.0051 0.0113 0.1313
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.1178
Echinococcus multilocularis cathepsin L cysteine protease 0.0109 0.0342 0.0907
Echinococcus granulosus cathepsin L cysteine proteinase 0.0109 0.0342 0.129
Entamoeba histolytica cysteine protease, putative 0.0066 0.0172 0.485
Trichomonas vaginalis calpain, putative 0.0048 0.0101 0.1178
Trypanosoma brucei calpain, putative 0.0048 0.0101 0.1178
Echinococcus granulosus calpain 5 0.0161 0.0545 0.2054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0172 0.2
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0161 0.0545 0.2054
Toxoplasma gondii cathepsin CPL 0.0109 0.0342 0.3985
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0056 0.0647
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0037 0.0056 0.0892
Plasmodium falciparum plasmepsin X 0.0181 0.0624 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0161 0.0545 0.6346
Brugia malayi Cathepsin L-like cysteine proteinase 0.008 0.0226 0.0226
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0695 0.2654 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0479 0.0479
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0037 0.0056 0.0892
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0056 0.0647
Echinococcus multilocularis cathepsin b 0.0695 0.2654 0.7029
Leishmania major DNA polymerase eta, putative 0.0023 0.0002 0.0027
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0048 0.0101 0.1178
Loa Loa (eye worm) hypothetical protein 0.0266 0.0959 0.0959
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0129 0.042 0.0877
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0027
Loa Loa (eye worm) hypothetical protein 0.008 0.0226 0.0226
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0128 0.0269
Toxoplasma gondii prolyl endopeptidase 0.0129 0.042 0.4883
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.0342 0.3985
Schistosoma mansoni calpain C (C02 family) 0.0161 0.0545 0.114
Schistosoma mansoni cathepsin D (A01 family) 0.0207 0.0728 0.1522
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0056 0.0647
Echinococcus multilocularis calpain 0.0161 0.0545 0.1444
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0109 0.0342 0.3985
Giardia lamblia DINP protein human, muc B family 0.0023 0.0002 0.0027
Echinococcus granulosus cathepsin l1 0.008 0.0226 0.0852
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0037 0.0056 0.0892
Brugia malayi Cathepsin L-like precursor 0.0109 0.0342 0.0342
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0161 0.0545 0.6346
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.2115 0.5601
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0002 0.0027
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0051 0.0113 1
Onchocerca volvulus 0.0109 0.0342 0.3572
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0129 0.042 0.0877
Trichomonas vaginalis calpain, putative 0.0048 0.0101 0.1178
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0037 0.0056 0.0647
Entamoeba histolytica cysteine proteinase, putative 0.0066 0.0172 0.485
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0695 0.2654 0.5551
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0002 0.0009
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0161 0.0545 0.2054
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Echinococcus multilocularis calpain A 0.0449 0.1683 0.4458
Entamoeba histolytica cysteine protease, putative 0.0066 0.0172 0.485
Entamoeba histolytica cysteine protease, putative 0.0066 0.0172 0.485
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0027
Trypanosoma cruzi cysteine peptidase, putative 0.0109 0.0342 0.129
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0109 0.0342 0.0342
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0161 0.0545 0.2054
Onchocerca volvulus Prolyl endopeptidase homolog 0.0129 0.042 0.4377
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0048 0.0101 0.0381
Brugia malayi cathepsin L-like precursor 0.008 0.0226 0.0226
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0115 0.0366 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.0056 0.0647
Giardia lamblia Hypothetical protein 0.0037 0.0056 0.0647
Giardia lamblia Cathepsin B precursor 0.0037 0.0056 0.0647
Loa Loa (eye worm) calpain D 0.0048 0.0101 0.0101
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0161 0.0545 0.2054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0172 0.2
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0037 0.0056 0.1569
Leishmania major cathepsin L-like protease 0.0109 0.0342 0.3985
Echinococcus granulosus neuropeptide s receptor 0.0558 0.2115 0.7968
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.008 0.0226 0.2632
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.1178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0109 0.0342 0.3985
Loa Loa (eye worm) ctsf protein 0.0109 0.0342 0.0342
Brugia malayi calpain 7 0.0161 0.0545 0.0545
Echinococcus multilocularis calpain 5 0.0161 0.0545 0.1444
Schistosoma mansoni Mername-AA248 (C02 family) 0.0161 0.0545 0.114
Onchocerca volvulus 0.008 0.0226 0.2359
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0051 0.0113 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.0342 0.3985
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0479 0.0479
Plasmodium vivax aspartyl protease, putative 0.0181 0.0624 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.024 0.0859 1
Entamoeba histolytica cysteine protease, putative 0.0066 0.0172 0.485
Leishmania major cysteine peptidase A (CPA) 0.0109 0.0342 0.3985
Loa Loa (eye worm) hypothetical protein 0.0378 0.1403 0.1403
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.1178
Giardia lamblia Cysteine protease 0.0037 0.0056 0.0647
Plasmodium vivax unspecified product 0.0037 0.0056 0.0892
Brugia malayi Cathepsin L-like precursor 0.008 0.0226 0.0226
Entamoeba histolytica cysteine protease, putative 0.0037 0.0056 0.1569
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.1178
Onchocerca volvulus 0.0109 0.0342 0.3572
Trypanosoma brucei calpain-like protein, putative 0.0161 0.0545 0.6346
Entamoeba histolytica cysteine protease, putative 0.0066 0.0172 0.485
Entamoeba histolytica cysteine protease, putative 0.0066 0.0172 0.485
Trypanosoma cruzi prolyl endopeptidase 0.0129 0.042 0.1581
Toxoplasma gondii hypothetical protein 0.0048 0.0101 0.1178
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.0056 0.0647
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0161 0.0545 0.2054
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0002 0.0006
Plasmodium vivax calpain, putative 0.0161 0.0545 0.8744
Trypanosoma cruzi conserved protein 0.0048 0.0101 0.0381
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0002 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.0342 0.3985
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.0342 0.3985
Giardia lamblia Cathepsin B precursor 0.024 0.0859 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.0342 0.3985
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0037 0.0056 0.0647
Onchocerca volvulus 0.0109 0.0342 0.3572
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.0381
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0002 0.0027
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.0381
Echinococcus multilocularis dna polymerase eta 0.0023 0.0002 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.0056 0.0647
Onchocerca volvulus 0.0037 0.0056 0.058
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0002 0.0027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0109 0.0342 0.3985
Mycobacterium tuberculosis Probable peptidase 0.0051 0.0113 0.3037
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0051 0.0113 0.0425
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0037 0.0056 0.1569
Onchocerca volvulus Cathepsin L homolog 0.0109 0.0342 0.3572
Loa Loa (eye worm) cysteine protease 0.0109 0.0342 0.0342
Trypanosoma cruzi cruzipain precursor, putative 0.0109 0.0342 0.129
Brugia malayi cathepsin F-like cysteine proteinase 0.0029 0.0027 0.0027
Brugia malayi cathepsin Z-like cysteine proteinase 0.0037 0.0056 0.0056
Echinococcus multilocularis calpain 7 (C02 family) 0.0161 0.0545 0.1444
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0161 0.0545 0.2054
Brugia malayi cathepsin L precursor 0.0037 0.0056 0.0056
Schistosoma mansoni calpain-7 (C02 family) 0.0161 0.0545 0.114
Entamoeba histolytica cysteine protease, putative 0.0037 0.0056 0.1569
Echinococcus multilocularis hypothetical protein 0.0161 0.0545 0.1444
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0109 0.0342 0.505
Leishmania major hypothetical protein, conserved 0.0048 0.0101 0.1178
Giardia lamblia Cysteine protease 0.0037 0.0056 0.0647
Trypanosoma cruzi cruzipain precursor, putative 0.0029 0.0027 0.01
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.0342 0.3985
Echinococcus granulosus cathepsin l1 0.0109 0.0342 0.129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.0342 0.3985
Brugia malayi cathepsin Z-like cysteine proteinase 0.0037 0.0056 0.0056
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0037 0.0056 0.0647
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0037 0.0056 0.0647
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0002 0.0002
Trypanosoma brucei calpain-like protein, putative 0.0161 0.0545 0.6346
Onchocerca volvulus 0.0109 0.0342 0.3572
Brugia malayi cathepsin B-like cysteine proteinase 0.0695 0.2654 0.2654
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0048 0.0101 0.0381
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0109 0.0342 0.3985
Leishmania major oligopeptidase b 0.0051 0.0113 0.1313
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0002 0.0009
Brugia malayi Cathepsin L-like precursor 0.0109 0.0342 0.0342
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.0342 0.3985
Brugia malayi cathepsin F-like cysteine proteinase 0.0037 0.0056 0.0056
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0056 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.0342 0.3985
Trypanosoma brucei calpain-like protein, putative 0.0161 0.0545 0.6346
Toxoplasma gondii aspartyl protease ASP3 0.0181 0.0624 0.7257
Loa Loa (eye worm) calpain family protein 1 0.0426 0.1594 0.1594
Echinococcus multilocularis cathepsin L 0.0037 0.0056 0.0147
Schistosoma mansoni cathepsin S (C01 family) 0.0037 0.0056 0.0116
Giardia lamblia Cathepsin L-like protease 0.0037 0.0056 0.0647
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.0342 0.3985
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0048 0.0101 0.0381
Plasmodium vivax vivapain-3 0.0066 0.0172 0.2756
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.0056 0.0056
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0037 0.0056 0.0892
Trypanosoma brucei hypothetical protein 0.0048 0.0101 0.1178
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Plasmodium falciparum calpain 0.0048 0.0101 0.0803
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0037 0.0056 0.0647
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0695 0.2654 0.5551
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0129 0.042 0.4883
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0037 0.0056 0.0116
Trypanosoma cruzi cysteine proteinase, putative 0.0066 0.0172 0.0648
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0048 0.0101 0.1178
Toxoplasma gondii cathepsin CPC1 0.0037 0.0056 0.0647
Trypanosoma cruzi cysteine peptidase, putative 0.0109 0.0342 0.129
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0002 0.0005
Plasmodium vivax vivapain-2 0.0109 0.0342 0.5491
Giardia lamblia Cathepsin B precursor 0.024 0.0859 1
Leishmania major calpain family cysteine protease-like protein 0.0048 0.0101 0.1178
Toxoplasma gondii cathepsin CPC2 0.0037 0.0056 0.0647
Leishmania major calpain protease-like protein 0.0048 0.0101 0.1178
Trypanosoma brucei kinesin, putative 0.0112 0.0354 0.4124
Giardia lamblia Cathepsin L-like protease 0.0037 0.0056 0.0647
Entamoeba histolytica cysteine protease, putative 0.0037 0.0056 0.1569
Echinococcus granulosus calpain 0.0161 0.0545 0.2054
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0109 0.0342 0.505
Leishmania major cathepsin L-like protease 0.0109 0.0342 0.3985
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0051 0.0113 0.1313
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0029 0.0027 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.1178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.0342 0.3985
Brugia malayi Papain family cysteine protease containing protein 0.0109 0.0342 0.0342
Plasmodium falciparum cysteine proteinase falcipain 3 0.0109 0.0342 0.505
Plasmodium vivax serine-repeat antigen (SERA) 0.0037 0.0056 0.0892
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0426 0.1594 0.3333
Onchocerca volvulus 0.0109 0.0342 0.3572
Giardia lamblia Cysteine protease 0.0037 0.0056 0.0647
Brugia malayi Cathepsin L-like precursor 0.0109 0.0342 0.0342
Entamoeba histolytica cysteine protease, putative 0.0066 0.0172 0.485
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0037 0.0056 0.0892
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0056 0.0056
Loa Loa (eye worm) calpain family protein 1 0.0314 0.1149 0.1149
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0161 0.0545 0.2054
Echinococcus multilocularis calpain family protein 1, d 0.0314 0.1149 0.3044
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0161 0.0545 0.6346
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0037 0.0056 0.0647
Giardia lamblia Cathepsin B precursor 0.0037 0.0056 0.0647
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0037 0.0056 0.0892
Schistosoma mansoni calpain (C02 family) 0.0161 0.0545 0.114
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.1178
Leishmania major cathepsin L-like protease 0.0109 0.0342 0.3985
Plasmodium vivax aspartyl protease, putative 0.0181 0.0624 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.0342 0.3985
Schistosoma mansoni cathepsin F (C01 family) 0.008 0.0226 0.0473
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0027
Giardia lamblia Cathepsin B precursor 0.0037 0.0056 0.0647
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0056 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0027
Entamoeba histolytica cysteine proteinase 2 0.0066 0.0172 0.485
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0037 0.0056 0.0116
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0048 0.0101 0.0381
Echinococcus multilocularis cathepsin b 0.0695 0.2654 0.7029
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0048 0.0101 0.1178
Giardia lamblia Hypothetical protein 0.0037 0.0056 0.0647
Echinococcus multilocularis cathepsin L 0.0066 0.0172 0.0455
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0109 0.0342 0.3985
Trypanosoma brucei Calpain-like protein 2 0.0048 0.0101 0.1178
Toxoplasma gondii preprocathepsin c precursor, putative 0.0037 0.0056 0.0647
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0449 0.1682 0.4455
Leishmania major cathepsin L-like protease 0.0109 0.0342 0.3985
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.0342 0.3985
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.024 0.0859 0.1797
Trypanosoma cruzi oligopeptidase b 0.0051 0.0113 0.0425
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0109 0.0342 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.0226 0.0226
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.2115 0.7968
Loa Loa (eye worm) hypothetical protein 0.008 0.0226 0.0226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0056 0.0647
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0449 0.1682 0.6339
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0161 0.0545 0.6346
Plasmodium vivax vivapain-1 0.0066 0.0172 0.2756
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0056 0.0647
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.1178
Trypanosoma cruzi cysteine peptidase, putative 0.0029 0.0027 0.01
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0128 0.034
Trypanosoma brucei cysteine peptidase C (CPC) 0.024 0.0859 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.0342 0.3985
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0109 0.0342 0.3985
Entamoeba histolytica cysteine protease, putative 0.0037 0.0056 0.1569
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.0342 0.3985
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0037 0.0056 0.0647
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0161 0.0545 0.2054
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0101 0.1178
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0002 0.0066
Trypanosoma brucei Calpain-like protein 1.2 0.0048 0.0101 0.1178
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0161 0.0545 0.6346

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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