Detailed information for compound 1414308

Basic information

Technical information
  • TDR Targets ID: 1414308
  • Name: N-(1,3-benzodioxol-5-ylmethyl)-2-[(5-cyclohex yl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl] propanamide
  • MW: 428.548 | Formula: C22H28N4O3S
  • H donors: 1 H acceptors: 3 LogP: 4.27 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCn1c(nnc1C1CCCCC1)SC(C(=O)NCc1ccc2c(c1)OCO2)C
  • InChi: 1S/C22H28N4O3S/c1-3-11-26-20(17-7-5-4-6-8-17)24-25-22(26)30-15(2)21(27)23-13-16-9-10-18-19(12-16)29-14-28-18/h3,9-10,12,15,17H,1,4-8,11,13-14H2,2H3,(H,23,27)
  • InChiKey: KFKAQPLYDIYAAB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-allyl-5-cyclohexyl-1,2,4-triazol-3-yl)sulfanyl]-N-(1,3-benzodioxol-5-ylmethyl)propanamide
  • 2-[(4-allyl-5-cyclohexyl-1,2,4-triazol-3-yl)thio]-N-(1,3-benzodioxol-5-ylmethyl)propanamide
  • 2-[(4-allyl-5-cyclohexyl-1,2,4-triazol-3-yl)thio]-N-(1,3-benzodioxol-5-ylmethyl)propionamide
  • T5423351
  • MLS000058286
  • SMR000065147

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0689 0.3295
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.2091 1
Onchocerca volvulus 0.0039 0.0463 0.1431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0358 0.0642
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0173 0.0348
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.043 0.0912
Echinococcus multilocularis cathepsin L 0.0017 0.0059 0.007
Leishmania major cathepsin L-like protease 0.0034 0.0358 0.1712
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.1372
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0173 0.0348
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.043 0.0511
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0064 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2091 1
Plasmodium vivax small ubiquitin-related modifier, putative 0.003 0.03 0.5021
Loa Loa (eye worm) hypothetical protein 0.0023 0.0173 0.0348
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0056 0.0781 0.157
Loa Loa (eye worm) hypothetical protein 0.0043 0.0541 0.1088
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0689 0.0818
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0463 0.0932
Loa Loa (eye worm) hypothetical protein 0.003 0.0301 0.0606
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0064 0.0159
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0358 0.0642
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0059 0.0125
Echinococcus granulosus cathepsin L 0.0017 0.0059 0.007
Schistosoma mansoni organic anion transporter 0.0083 0.1264 0.2679
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0172 0.2902 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0463 0.0932
Loa Loa (eye worm) hypothetical protein 0.0039 0.0463 0.0932
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0358 0.0642
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0689 0.1352
Loa Loa (eye worm) hypothetical protein 0.0039 0.0463 0.0932
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0463 0.0932
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0173 0.4019
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0541 0.2589
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.003 0.03 0.0635
Echinococcus granulosus cathepsin l1 0.0022 0.0154 0.0183
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0358 0.072
Onchocerca volvulus Putative organic anion transporter 0.0083 0.1264 0.4243
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2091 1
Echinococcus granulosus cathepsin l1 0.0034 0.0358 0.0425
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0058 0.0804 0.3846
Brugia malayi Protein kinase domain containing protein 0.0017 0.0056 0.0113
Plasmodium falciparum small ubiquitin-related modifier 0.003 0.03 0.8069
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0173 0.0348
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.1372
Loa Loa (eye worm) hypothetical protein 0.0083 0.1264 0.254
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.043 0.0797
Mycobacterium ulcerans beta-lactamase 0.0043 0.0541 0.0481
Loa Loa (eye worm) hypothetical protein 0.0034 0.0358 0.072
Loa Loa (eye worm) hypothetical protein 0.0039 0.0463 0.0932
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0056 0.0268
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0173 0.011
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0689 0.3295
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.0206 0.3531 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0059 0.0125
Onchocerca volvulus Peroxidase homolog 0.0039 0.0463 0.1431
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.2091 1
Brugia malayi Blistered cuticle protein 3 0.0039 0.0463 0.0932
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0541 0.0497
Toxoplasma gondii cathepsin CPL 0.0034 0.0358 0.1014
Onchocerca volvulus 0.0039 0.0463 0.1431
Echinococcus granulosus neuropeptide s receptor 0.0472 0.8419 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0358 0.0642
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.1372
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0358 0.0759
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0689 0.1352
Echinococcus granulosus neuropeptide receptor A26 0.0472 0.8419 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0017 0.0059 0.1372
Plasmodium vivax vivapain-1 0.0017 0.0059 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0358 0.0642
Loa Loa (eye worm) prolyl oligopeptidase 0.0172 0.2902 0.5834
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0128
Toxoplasma gondii protease inhibitor PI2 0.0056 0.0781 0.2211
Loa Loa (eye worm) hypothetical protein 0.0043 0.0541 0.1088
Echinococcus granulosus follistatin 0.0056 0.0781 0.0927
Onchocerca volvulus 0.0034 0.0358 0.1061
Leishmania major cathepsin L-like protease 0.0128 0.2091 1
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0358 0.1712
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0056 0.0781 0.157
Echinococcus granulosus Solute carrier organic anion transporter family 0.0083 0.1264 0.1501
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2091 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.1264 0.254
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0541 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0541 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.1264 0.254
Loa Loa (eye worm) SMO-1 protein 0.003 0.03 0.0603
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0358 1
Schistosoma mansoni agrin 0.0056 0.0781 0.1655
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0358 1
Brugia malayi MAP kinase sur-1 0.0052 0.0689 0.1385
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0358 0.0642
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0541 0.1036
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0058 0.0804 0.3846
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0358 0.072
Brugia malayi prolyl oligopeptidase family protein 0.0058 0.0804 0.1616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0358 0.0642
Loa Loa (eye worm) TK/ROR protein kinase 0.0017 0.0056 0.0113
Brugia malayi SPARC precursor 0.0056 0.0781 0.157
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0541 0.1088
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0358 0.1061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2091 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.0173 0.011
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0358 0.0425
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0541 0.0497
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0059 0.0282
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0541 0.0497
Trypanosoma brucei protein kinase, putative 0.0052 0.0689 0.3295
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0541 0.0643
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0358 0.0642
Mycobacterium tuberculosis Conserved protein 0.0043 0.0541 0.0497
Brugia malayi beta-lactamase family protein 0.0043 0.0541 0.1088
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0358 0.072
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0358 0.1712
Loa Loa (eye worm) hypothetical protein 0.0039 0.0463 0.0932
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0541 0.1088
Brugia malayi Kringle domain containing protein 0.0017 0.0056 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0541 0.2589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0059 0.0282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0154 0.0204
Onchocerca volvulus 0.0034 0.0358 0.1061
Toxoplasma gondii ABC1 family protein 0.0043 0.0541 0.1533
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0154 0.0327
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0059 0.0119
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.1372
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0689 0.3295
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0463 0.0932
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0056 0.0781 0.157
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1091 0.1295
Loa Loa (eye worm) glutaminase 2 0.027 0.4717 0.9481
Entamoeba histolytica ubiquitin like protein 0.003 0.03 0.6967
Brugia malayi hypothetical protein 0.0044 0.0554 0.1113
Brugia malayi sodium-independent organic anion transporter family protein 0.0083 0.1264 0.254
Echinococcus multilocularis expressed protein 0.0056 0.0781 0.0927
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0083 0.1264 0.1501
Echinococcus multilocularis cysteine protease 0.0034 0.0358 0.0425
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0689 0.3295
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.043 0.2058
Trypanosoma cruzi cruzipain precursor, putative 0.0128 0.2091 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0173 0.011
Echinococcus granulosus Dipeptidyl peptidase 9 0.0058 0.0804 0.0955
Mycobacterium ulcerans glutaminase 0.027 0.4717 0.4683
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0059 0.0282
Schistosoma mansoni hypothetical protein 0.0017 0.0056 0.0119
Echinococcus granulosus tissue type plasminogen activator 0.0017 0.0056 0.0067
Onchocerca volvulus Chorion peroxidase homolog 0.0039 0.0463 0.1431
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0173 0.011
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0358 0.8322
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0541 0.1148
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0064 0.0018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0358 0.0642
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0059 0.0282
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0358 0.0642
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2091 1
Echinococcus multilocularis Small ubiquitin modifier 2 0.003 0.03 0.0356
Loa Loa (eye worm) hypothetical protein 0.0023 0.0173 0.0348
Mycobacterium tuberculosis Conserved protein 0.0043 0.0541 0.0497
Brugia malayi Cathepsin L-like precursor 0.0022 0.0154 0.031
Loa Loa (eye worm) hypothetical protein 0.0022 0.0154 0.031
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0541 0.1036
Brugia malayi hypothetical protein 0.002 0.0103 0.0207
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0463 0.0932
Onchocerca volvulus Putative organic anion transporter 0.0083 0.1264 0.4243
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.1372
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0173 0.011
Trypanosoma brucei small ubiquitin-related modifier 0.003 0.03 0.1434
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0173 0.011
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.1372
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0058 0.0804 0.3846
Plasmodium vivax unspecified product 0.0017 0.0059 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2091 1
Entamoeba histolytica cysteine protease, putative 0.0034 0.0358 0.8322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0358 0.0642
Loa Loa (eye worm) hypothetical protein 0.0022 0.0154 0.031
Brugia malayi Ubiquitin-like protein SMT3 0.003 0.03 0.0603
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.1372
Trichomonas vaginalis conserved hypothetical protein 0.003 0.03 0.0517
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0173 0.0827
Echinococcus multilocularis neuropeptide s receptor 0.0472 0.8419 1
Schistosoma mansoni follistatin 0.0056 0.0781 0.1655
Trypanosoma cruzi small ubiquitin protein, putative 0.003 0.03 0.1434
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0301 0.8126
Loa Loa (eye worm) beta-lactamase 0.0043 0.0541 0.1088
Toxoplasma gondii kringle domain-containing protein 0.0017 0.0056 0.0159
Leishmania major hypothetical protein, conserved 0.0017 0.0056 0.0268
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0689 0.1385
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0083 0.1264 0.254
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0301 0.0854
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0056 0.0781 0.157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0358 0.0642
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0154 0.3584
Onchocerca volvulus Peroxidasin homolog 0.0039 0.0463 0.1431
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0059 0.1372
Onchocerca volvulus 0.0083 0.1264 0.4243
Echinococcus multilocularis follistatin 0.0056 0.0781 0.0927
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0059 0.1372
Echinococcus multilocularis peroxidasin 0.0039 0.0463 0.0551
Brugia malayi Cathepsin L-like precursor 0.0034 0.0358 0.072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0358 0.0642
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.1372
Brugia malayi Cathepsin L-like precursor 0.0034 0.0358 0.072
Loa Loa (eye worm) hypothetical protein 0.0083 0.1264 0.254
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0358 0.8322
Onchocerca volvulus 0.0034 0.0358 0.1061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0358 0.0642
Brugia malayi Cathepsin L-like precursor 0.0034 0.0358 0.072
Echinococcus granulosus peroxidasin 0.0039 0.0463 0.0551
Leishmania major cathepsin L-like protease 0.0034 0.0358 0.1712
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0173 0.0827
Onchocerca volvulus 0.0034 0.0358 0.1061
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0463 0.0932
Entamoeba histolytica cysteine proteinase 2 0.0017 0.0059 0.1372
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0358 0.0425
Onchocerca volvulus 0.0083 0.1264 0.4243
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0358 0.0642
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0173 0.0127
Echinococcus multilocularis cysteine protease 0.0034 0.0358 0.0425
Onchocerca volvulus 0.0034 0.0358 0.1061
Mycobacterium leprae Probable lipase LipE 0.0043 0.0541 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2091 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0463 0.0932
Brugia malayi Cathepsin L-like precursor 0.0034 0.0358 0.072
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0173 0.011
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0173 0.0127
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0463 0.0932
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0128
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0689 0.1951
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0358 0.1061
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0689 1
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0059 0.1372
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.043 0.0797
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1091 0.1295
Loa Loa (eye worm) hypothetical protein 0.0023 0.0173 0.0348
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0056 0.0781 0.2211
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.043 0.0865
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0083 0.1264 0.1501
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1091 0.1033
Brugia malayi secreted modular calcium-binding protein 1 0.0056 0.0781 0.157
Loa Loa (eye worm) hypothetical protein 0.0056 0.0781 0.157
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1091 0.1049
Onchocerca volvulus 0.0083 0.1264 0.4243
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0358 0.0425
Loa Loa (eye worm) hypothetical protein 0.0039 0.0463 0.0932
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0058 0.0804 0.2277
Loa Loa (eye worm) hypothetical protein 0.0039 0.0463 0.0932
Toxoplasma gondii transporter, major facilitator family protein 0.0083 0.1264 0.3579
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0358 0.0425
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2091 1
Brugia malayi hypothetical protein 0.0039 0.0463 0.0932
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0117 0.1887 0.9025
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0358 0.0425
Loa Loa (eye worm) hypothetical protein 0.0039 0.0463 0.0932
Loa Loa (eye worm) blistered cuticle protein 3 0.0039 0.0463 0.0932
Onchocerca volvulus 0.0043 0.0541 0.1705
Loa Loa (eye worm) hypothetical protein 0.0043 0.0541 0.1088
Loa Loa (eye worm) hypothetical protein 0.0056 0.0781 0.157
Trypanosoma cruzi small ubiquitin protein, putative 0.003 0.03 0.1434
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0173 0.011
Onchocerca volvulus Putative organic anion transporter 0.0083 0.1264 0.4243
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0113
Onchocerca volvulus 0.0056 0.0781 0.2546
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2091 1
Trichomonas vaginalis glutaminase, putative 0.027 0.4717 1
Brugia malayi prostaglandin transporter 0.0083 0.1264 0.254
Brugia malayi Cathepsin L-like precursor 0.0034 0.0358 0.072
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0689 0.0818
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0689 0.3295
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0541 0.0497
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.1372
Schistosoma mansoni peroxidasin 0.0039 0.0463 0.0983
Echinococcus granulosus agrin 0.0056 0.0781 0.0927
Onchocerca volvulus 0.0023 0.0173 0.041
Trypanosoma cruzi major cysteine proteinase, putative 0.01 0.1588 0.7595
Onchocerca volvulus 0.0018 0.0079 0.008
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0463 0.0932
Plasmodium vivax vivapain-2 0.0034 0.0358 0.6222
Loa Loa (eye worm) hypothetical protein 0.0043 0.0541 0.1088
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0059 0.007
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0541 0.0497
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.043 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0358 0.0642
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0301 0.5056
Echinococcus multilocularis neuropeptide receptor A26 0.0472 0.8419 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0128
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1091 0.5216
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0058 0.0804 0.3846
Mycobacterium ulcerans short chain dehydrogenase 0.0558 1 1
Onchocerca volvulus 0.0039 0.0463 0.1431
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0358 0.1061
Loa Loa (eye worm) hypothetical protein 0.0044 0.0554 0.1113
Leishmania major small ubiquitin protein, putative 0.003 0.03 0.1434
Mycobacterium tuberculosis Conserved protein 0.0043 0.0541 0.0497
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0541 0.1036
Brugia malayi cathepsin L-like precursor 0.0022 0.0154 0.031
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.043 0.2058
Plasmodium vivax vivapain-2 0.0034 0.0358 0.6222
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.1372
Brugia malayi Cathepsin L-like precursor 0.0034 0.0358 0.072
Plasmodium falciparum cysteine proteinase falcipain 1 0.0017 0.0059 0.0097
Onchocerca volvulus 0.0043 0.0541 0.1705
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0689 0.1461
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0689 0.3295
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.1372
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0172 0.2902 0.3447
Onchocerca volvulus Peroxidase homolog 0.0039 0.0463 0.1431
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0541 0.1148
Onchocerca volvulus 0.0043 0.0541 0.1705
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0463 0.0932
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0064 0.0255
Loa Loa (eye worm) hypothetical protein 0.0083 0.1264 0.254
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0059 0.0119
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1091 0.2312
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0301 0.1442
Loa Loa (eye worm) hypothetical protein 0.0039 0.0463 0.0932
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.2091 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0358 0.0642
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0358 0.0759
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0083 0.1264 0.1501
Brugia malayi beta-lactamase family protein 0.0043 0.0541 0.1088
Loa Loa (eye worm) fibroinase 0.0034 0.0358 0.072
Loa Loa (eye worm) hypothetical protein 0.0039 0.0463 0.0932
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0058 0.0804 0.0955
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0172 0.2902 0.6153
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0058 0.0804 0.1705
Brugia malayi glutaminase DH11.1 0.027 0.4717 0.9481
Leishmania major hypothetical protein, conserved 0.0043 0.0541 0.2589
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.043 0.2058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0358 0.0642
Onchocerca volvulus 0.0022 0.0154 0.0345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0358 0.0642
Loa Loa (eye worm) agrin synaptic family protein 0.0056 0.0781 0.157
Brugia malayi beta-lactamase 0.0043 0.0541 0.1088
Loa Loa (eye worm) hypothetical protein 0.0039 0.0463 0.0932
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.043 0.0511
Onchocerca volvulus 0.0083 0.1264 0.4243
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0358 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1091 0.1033
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0059 0.0125
Loa Loa (eye worm) hypothetical protein 0.0039 0.0463 0.0932
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0173 0.4019
Onchocerca volvulus 0.0034 0.0358 0.1061
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0689 0.1352
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0128
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0056 0.0781 0.157
Loa Loa (eye worm) cysteine protease 0.0034 0.0358 0.072
Loa Loa (eye worm) hypothetical protein 0.0043 0.0541 0.1088
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0358 0.0425
Echinococcus multilocularis agrin 0.0056 0.0781 0.0927
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0463 0.0932
Onchocerca volvulus 0.0083 0.1264 0.4243
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0689 0.1352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0154 0.0204
Trichomonas vaginalis esterase, putative 0.0043 0.0541 0.1036
Brugia malayi prolyl oligopeptidase family protein 0.0172 0.2902 0.5834
Leishmania major cathepsin L-like protease 0.0034 0.0358 0.1712
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0059 0.0282
Echinococcus multilocularis tissue type plasminogen activator 0.0017 0.0056 0.0067
Schistosoma mansoni glutaminase 0.027 0.4717 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2091 1
Loa Loa (eye worm) ctsf protein 0.0034 0.0358 0.072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2091 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0781 0.157
Schistosoma mansoni peroxidasin 0.0039 0.0463 0.0983
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0059 0.0282
Schistosoma mansoni organic anion transporter 0.0083 0.1264 0.2679
Echinococcus granulosus Small ubiquitin modifier 2 0.003 0.03 0.0356
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.043 0.6245
Onchocerca volvulus 0.0034 0.0358 0.1061
Loa Loa (eye worm) hypothetical protein 0.0056 0.0781 0.157
Brugia malayi hypothetical protein 0.0083 0.1264 0.254
Mycobacterium ulcerans hypothetical protein 0.0043 0.0541 0.0481
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0058 0.0804 0.3846
Leishmania major cathepsin L-like protease 0.0128 0.2091 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.0154 0.031
Loa Loa (eye worm) hypothetical protein 0.0083 0.1264 0.254
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.043 0.0511
Loa Loa (eye worm) hypothetical protein 0.0043 0.0541 0.1088
Toxoplasma gondii small ubiquitin family modifier, putative 0.003 0.03 0.0849
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0358 0.0642
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0689 0.0818
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.043 0.0511
Mycobacterium ulcerans lipase LipD 0.0043 0.0541 0.0481
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.043 0.0797
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0284 0.4975 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0541 0.0497
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0689 0.0818
Brugia malayi sodium-independent organic anion transporter family protein 0.0083 0.1264 0.254
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0358 0.0642
Brugia malayi hypothetical protein 0.003 0.0301 0.0606
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0541 0.1036
Leishmania major cathepsin L-like protease 0.0034 0.0358 0.1712
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0059 0.1372
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0056 0.0781 0.2211
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.4852 0.4828
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0689 0.3295
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0358 0.0642
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0541 0.0481
Giardia lamblia Sentrin 0.003 0.03 0.4351
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.043 0.0511
Brugia malayi Peroxidasin 0.0039 0.0463 0.0932
Brugia malayi Cathepsin L-like precursor 0.0022 0.0154 0.031
Onchocerca volvulus Dual oxidase homolog 0.0039 0.0463 0.1431
Loa Loa (eye worm) glutaminase 0.027 0.4717 0.9481
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0541 0.2589
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.043 0.0912
Loa Loa (eye worm) hypothetical protein 0.0083 0.1264 0.254
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0301 0.1442
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.1372
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0541 0.1036
Loa Loa (eye worm) hypothetical protein 0.0037 0.043 0.0865
Loa Loa (eye worm) hypothetical protein 0.0039 0.0463 0.0932
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0172 0.2902 0.3447
Trypanosoma cruzi MFS transporter, putative 0.0083 0.1264 0.6044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0358 0.0642
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0541 0.0643
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0173 0.4019
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.043 0.2058
Leishmania major cathepsin L-like protease 0.0034 0.0358 0.1712
Brugia malayi sodium-independent organic anion transporter family protein 0.0083 0.1264 0.254
Loa Loa (eye worm) hypothetical protein 0.0022 0.0154 0.031
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0541 0.0481
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1091 0.3088
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.043 0.0511
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0059 0.0282
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1091 0.2312
Echinococcus granulosus cysteine protease 0.0017 0.0059 0.007
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0301 0.1442
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0056 0.0781 0.2211
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0301 0.8126
Onchocerca volvulus Peroxidasin homolog 0.0039 0.0463 0.1431
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.1372
Leishmania major cathepsin L-like protease 0.0128 0.2091 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0541 0.0497
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0358 0.0642
Plasmodium vivax vivapain-3 0.0017 0.0059 0.0061
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0128
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1091 0.1033
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0056 0.0781 0.2211
Brugia malayi follicle stimulating hormone receptor 0.0284 0.4975 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0358 0.0642
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0173 0.0827
Brugia malayi hypothetical protein 0.0083 0.1264 0.254
Leishmania major hypothetical protein, conserved 0.003 0.0301 0.1442

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0828 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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