Detailed information for compound 1430532

Basic information

Technical information
  • TDR Targets ID: 1430532
  • Name: 4-(3-methoxyphenyl)-2-pyrazol-1-yl-6-(trifluo romethyl)pyrimidine
  • MW: 320.269 | Formula: C15H11F3N4O
  • H donors: 0 H acceptors: 3 LogP: 3.06 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)c1cc(nc(n1)n1cccn1)C(F)(F)F
  • InChi: 1S/C15H11F3N4O/c1-23-11-5-2-4-10(8-11)12-9-13(15(16,17)18)21-14(20-12)22-7-3-6-19-22/h2-9H,1H3
  • InChiKey: BUYUUUOBQAZMNI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(3-methoxyphenyl)-2-(1-pyrazolyl)-6-(trifluoromethyl)pyrimidine
  • ChemDiv3_008344
  • MLS000520040
  • SMR000130455
  • IDI1_026254

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0064 0.0861
Brugia malayi sulfakinin receptor protein 0.034 0.1327 0.3523
Onchocerca volvulus 0.034 0.1327 0.475
Brugia malayi hypothetical protein 0.0042 0.0073 0.0165
Echinococcus multilocularis integrin alpha ps 0.0143 0.0499 0.048
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.034 0.1327 0.131
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Loa Loa (eye worm) hypothetical protein 0.0036 0.0048 0.0127
Schistosoma mansoni amine GPCR 0.034 0.1327 0.386
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0091 0.028 0.0748
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0042 0.0073 0.0165
Echinococcus granulosus glycine receptor subunit beta 0.0091 0.0278 0.0259
Echinococcus multilocularis SWI:SNF matrix associated 0.0042 0.0076 0.0057
Onchocerca volvulus 0.034 0.1327 0.475
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0034 0.0062
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0049 0.0103 0.0246
Echinococcus multilocularis adam 0.0033 0.0035 0.0015
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0398 0.1116
Brugia malayi steroid hormone receptor 0.0062 0.0156 0.0389
Echinococcus multilocularis glycine receptor subunit beta 0.0091 0.0278 0.0259
Schistosoma mansoni hypothetical protein 0.0031 0.0029 0.003
Echinococcus multilocularis two pore calcium channel protein 1 0.0091 0.028 0.0261
Onchocerca volvulus 0.034 0.1327 0.475
Schistosoma mansoni voltage-gated potassium channel 0.0091 0.028 0.077
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0062 0.0156 0.0404
Loa Loa (eye worm) ACC-1 protein 0.0091 0.0278 0.0743
Loa Loa (eye worm) AUR protein kinase 0.0114 0.0377 0.1006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0052
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0091 0.028 0.0947
Brugia malayi putative neuropeptide receptor NPR1 0.034 0.1327 0.3523
Brugia malayi ephrin receptor 1 precursor 0.0032 0.0032 0.0057
Onchocerca volvulus 0.034 0.1327 0.475
Brugia malayi Cation transporter family protein 0.0091 0.0278 0.0716
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0062 0.0156 0.0417
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Brugia malayi olfactory channel protein osm-9 0.0091 0.028 0.072
Brugia malayi TAR-binding protein 0.0076 0.0219 0.0558
Schistosoma mansoni RAR-like nuclear receptor 0.0062 0.0156 0.0404
Echinococcus granulosus two pore calcium channel protein 1 0.0091 0.028 0.0261
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0091 0.028 0.072
Brugia malayi Dopamine receptor 0.034 0.1327 0.3523
Echinococcus granulosus 7TM GPCR rhodopsin 0.034 0.1327 0.131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.034 0.1327 0.386
Echinococcus multilocularis transient receptor potential cation channel 0.0091 0.028 0.0261
Schistosoma mansoni ryanodine receptor related 0.0091 0.028 0.077
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0091 0.0278 0.0716
Schistosoma mansoni voltage-gated potassium channel 0.0091 0.028 0.077
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0062 0.0156 0.0137
Echinococcus granulosus fmrfamide receptor 0.034 0.1327 0.131
Brugia malayi Trypsin family protein 0.0119 0.0398 0.1035
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Brugia malayi PAN domain containing protein 0.0128 0.0434 0.1134
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0029 0.0079
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0091 0.0278 0.0716
Schistosoma mansoni hypothetical protein 0.0119 0.0398 0.1116
Onchocerca volvulus 0.034 0.1327 0.475
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0042 0.0076 0.0057
Brugia malayi PAN domain containing protein 0.0128 0.0434 0.1134
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0062 0.0156 0.0417
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0091 0.028 0.072
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0091 0.028 0.0261
Onchocerca volvulus 0.034 0.1327 0.475
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0019 0.0023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0156 0.0137
Onchocerca volvulus 0.034 0.1327 0.475
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.0743
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0079 0.007
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.034 0.1327 0.386
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.034 0.1327 0.3523
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Schistosoma mansoni coup transcription factor 0.0062 0.0156 0.0404
Schistosoma mansoni hypothetical protein 0.0042 0.0076 0.0167
Loa Loa (eye worm) hypothetical protein 0.0042 0.0073 0.0194
Onchocerca volvulus 0.0119 0.0398 0.1374
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.3407 1
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0091 0.028 0.0261
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0091 0.0278 0.0716
Schistosoma mansoni opsin-like receptor 0.034 0.1327 0.386
Loa Loa (eye worm) hypothetical protein 0.0042 0.0073 0.0194
Schistosoma mansoni rhodopsin-like orphan GPCR 0.034 0.1327 0.386
Brugia malayi nuclear receptor NHR-88 0.0062 0.0156 0.0389
Schistosoma mansoni growth hormone secretagogue receptor 0.034 0.1327 0.386
Loa Loa (eye worm) hypothetical protein 0.0202 0.0747 0.1995
Schistosoma mansoni voltage-gated potassium channel 0.0091 0.028 0.077
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0183 0.046
Schistosoma mansoni neuropeptide F-like receptor 0.034 0.1327 0.386
Brugia malayi voltage-dependent calcium channel 0.0091 0.028 0.072
Echinococcus multilocularis GPCR, family 2 0.0031 0.0029 0.001
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.0743
Onchocerca volvulus 0.0091 0.028 0.0947
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0042 0.0073 0.0053
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0315 0.0815
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0202 0.0747 0.0729
Echinococcus multilocularis thyroid hormone receptor alpha 0.0062 0.0156 0.0137
Schistosoma mansoni serine-type protease inhibitor 0.0446 0.1775 0.5184
Echinococcus granulosus neuropeptide receptor A26 0.034 0.1327 0.131
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Echinococcus multilocularis shaker cognate 0.0091 0.028 0.0261
Schistosoma mansoni voltage-gated potassium channel 0.0091 0.028 0.077
Loa Loa (eye worm) AUR protein kinase 0.0114 0.0377 0.1006
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0091 0.028 0.0261
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Echinococcus multilocularis voltage gated potassium channel 0.0091 0.028 0.0261
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0091 0.028 0.0261
Echinococcus multilocularis neuropeptide Y receptor 0.034 0.1327 0.131
Schistosoma mansoni voltage-gated potassium channel 0.0091 0.028 0.077
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0202 0.0747 0.0729
Echinococcus granulosus transient receptor potential cation channel 0.0091 0.028 0.0261
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.034 0.1327 0.386
Toxoplasma gondii PAN domain-containing protein 0.0128 0.0434 0.0627
Brugia malayi Trypsin family protein 0.0119 0.0398 0.1035
Onchocerca volvulus 0.0128 0.0434 0.1508
Loa Loa (eye worm) ion channel NompC 0.0091 0.028 0.0748
Onchocerca volvulus 0.0119 0.0398 0.1374
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0049 0.0103 0.0246
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0073 0.0595
Schistosoma mansoni nAChR subunit 0.0091 0.0278 0.0764
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0062 0.0156 0.0389
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0202 0.0747 0.0729
Loa Loa (eye worm) hypothetical protein 0.0099 0.0315 0.0842
Brugia malayi hypothetical protein 0.0042 0.0073 0.0165
Loa Loa (eye worm) hypothetical protein 0.0202 0.0747 0.1995
Loa Loa (eye worm) hypothetical protein 0.0068 0.0185 0.0495
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.017 0.0612 0.0593
Echinococcus granulosus transient receptor potential gamma protein 0.0091 0.028 0.0261
Echinococcus granulosus neuropeptide Y receptor 0.034 0.1327 0.131
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.034 0.1327 0.386
Echinococcus granulosus neuropeptide s receptor 0.034 0.1327 0.131
Echinococcus multilocularis neuropeptides capa receptor 0.034 0.1327 0.131
Schistosoma mansoni nAChR subunit 0.0091 0.0278 0.0764
Echinococcus granulosus neuropeptide receptor 0.034 0.1327 0.131
Brugia malayi PAN domain containing protein 0.0128 0.0434 0.1134
Brugia malayi Muscle positioning protein 4 0.0036 0.0048 0.0098
Schistosoma mansoni neuropeptide receptor 0.034 0.1327 0.386
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0091 0.028 0.7173
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0052
Toxoplasma gondii transporter, cation channel family protein 0.0091 0.028 0.0385
Loa Loa (eye worm) voltage-gated calcium channel 0.0091 0.028 0.0748
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.0106
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0156 0.0137
Echinococcus granulosus transient receptor potential cation channel 0.0091 0.028 0.0261
Echinococcus multilocularis Mastin 0.0119 0.0398 0.0379
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0062 0.0156 0.0404
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0202 0.0747 0.0729
Plasmodium falciparum cysteine repeat modular protein 1 0.006 0.0152 0.2807
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0398 0.1116
Echinococcus granulosus rhodopsin orphan GPCR 0.034 0.1327 0.131
Schistosoma mansoni hypothetical protein 0.0031 0.0029 0.003
Brugia malayi nuclear receptor RXR 0.0033 0.0034 0.0062
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Echinococcus multilocularis transient receptor potential cation channel 0.0091 0.028 0.0261
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.0743
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.1186 0.489 0.488
Echinococcus granulosus biogenic amine 5HT receptor 0.034 0.1327 0.131
Echinococcus multilocularis transient receptor potential cation channel 0.0091 0.028 0.0261
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.034 0.1327 0.131
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0119 0.0398 0.0379
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0062 0.0156 0.0137
Echinococcus granulosus transmembrane protease serine 3 0.0119 0.0398 0.0379
Echinococcus granulosus short transient receptor potential channel 6 0.0091 0.028 0.0261
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0034 0.0015
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0091 0.028 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0156 0.0389
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0062 0.0156 0.0137
Schistosoma mansoni opsin-like receptor 0.034 0.1327 0.386
Loa Loa (eye worm) hypothetical protein 0.0128 0.0434 0.116
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.11 0.1082
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Schistosoma mansoni transient receptor potential channel 4 0.0091 0.028 0.077
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0091 0.028 0.0261
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0091 0.0278 0.0259
Onchocerca volvulus Protein ultraspiracle homolog 0.0062 0.0156 0.0497
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0091 0.028 0.072
Loa Loa (eye worm) G-protein coupled receptor 0.034 0.1327 0.3542
Brugia malayi hypothetical protein 0.0091 0.028 0.072
Brugia malayi EGF-like domain containing protein 0.0033 0.0035 0.0063
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0091 0.028 0.077
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0091 0.028 0.0261
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.017 0.0612 0.0593
Loa Loa (eye worm) hypothetical protein 0.0033 0.0034 0.0091
Schistosoma mansoni hypothetical protein 0.0042 0.0076 0.0167
Brugia malayi hypothetical protein 0.034 0.1327 0.3523
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0052
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0029 0.0049
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0091 0.028 0.0261
Schistosoma mansoni voltage-gated potassium channel 0.0091 0.028 0.077
Loa Loa (eye worm) hypothetical protein 0.0049 0.0103 0.0274
Echinococcus granulosus sodium leak channel non selective protein 0.0091 0.028 0.0261
Toxoplasma gondii PAN domain-containing protein 0.0128 0.0434 0.0627
Schistosoma mansoni hypothetical protein 0.0068 0.0185 0.049
Schistosoma mansoni nAChR subunit 0.0091 0.0278 0.0764
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0019 0.0052
Onchocerca volvulus 0.0091 0.0278 0.094
Loa Loa (eye worm) hypothetical protein 0.0033 0.0034 0.0091
Schistosoma mansoni biogenic amine (5HT) receptor 0.034 0.1327 0.386
Echinococcus granulosus alpha 1A adrenergic receptor 0.034 0.1327 0.131
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0073 0.0595
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0091 0.028 0.072
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.034 0.1327 0.3523
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0156 0.0389
Echinococcus multilocularis hyperpolarization activated cyclic 0.0091 0.028 0.0261
Brugia malayi G protein-coupled receptor F59B2.13 0.034 0.1327 0.3523
Schistosoma mansoni rhodopsin-like orphan GPCR 0.034 0.1327 0.386
Chlamydia trachomatis SWIB complex protein 0.0042 0.0076 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.034 0.1327 0.131
Onchocerca volvulus 0.034 0.1327 0.475
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0119 0.0398 0.0379
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0073 0.111
Schistosoma mansoni hypothetical protein 0.034 0.1327 0.386
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0398 0.1116
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.0517 0.1353
Echinococcus multilocularis somatostatin receptor 0.034 0.1327 0.131
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Onchocerca volvulus 0.0091 0.0278 0.094
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0049 0.0103 0.0246
Loa Loa (eye worm) hypothetical protein 0.0042 0.0073 0.0194
Onchocerca volvulus 0.005 0.0107 0.0319
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.013 0.0111
Echinococcus granulosus g protein coupled receptor 0.034 0.1327 0.131
Echinococcus multilocularis voltage gated potassium channel 0.0091 0.028 0.0261
Echinococcus granulosus G protein coupled receptor 139 0.034 0.1327 0.131
Onchocerca volvulus 0.0067 0.0178 0.0574
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0091 0.0278 0.0716
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0091 0.0278 0.0259
Echinococcus granulosus glycine receptor subunit alpha 1 0.0091 0.0278 0.0259
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0062 0.0156 0.0404
Schistosoma mansoni transient receptor potential channel 0.0091 0.028 0.077
Loa Loa (eye worm) hypothetical protein 0.0042 0.0073 0.0194
Loa Loa (eye worm) hypothetical protein 0.0683 0.2773 0.74
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0091 0.028 0.077
Schistosoma mansoni nAChR subunit 0.0091 0.0278 0.0764
Echinococcus multilocularis alpha 1A adrenergic receptor 0.034 0.1327 0.131
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0079 0.0109
Echinococcus granulosus orexin receptor type 2 0.034 0.1327 0.131
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0091 0.028 0.077
Schistosoma mansoni neuropeptide receptor 0.034 0.1327 0.386
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0052
Echinococcus multilocularis glycine receptor subunit beta 0.0091 0.0278 0.0259
Loa Loa (eye worm) PAN domain-containing protein 0.0128 0.0434 0.116
Echinococcus multilocularis rhodopsin orphan GPCR 0.034 0.1327 0.131
Loa Loa (eye worm) hypothetical protein 0.0119 0.0398 0.1061
Brugia malayi nuclear hormone receptor 0.0062 0.0156 0.0389
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0202 0.0747 0.2149
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0202 0.0747 1
Chlamydia trachomatis DNA topoisomerase I 0.0042 0.0076 0.5
Echinococcus multilocularis serotonin receptor 0.034 0.1327 0.131
Schistosoma mansoni hypothetical protein 0.0032 0.0031 0.0034
Echinococcus granulosus integrin alpha 3 0.0244 0.0926 0.0908
Loa Loa (eye worm) hypothetical protein 0.0042 0.0073 0.0194
Toxoplasma gondii PAN domain-containing protein 0.1548 0.6415 1
Schistosoma mansoni 60S ribosomal protein L21 0.0091 0.028 0.077
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.034 0.1327 0.131
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0091 0.028 0.072
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0091 0.028 0.0261
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0091 0.028 0.0261
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0091 0.028 0.077
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Schistosoma mansoni voltage-gated potassium channel 0.0091 0.028 0.077
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.034 0.1327 0.3542
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0079
Brugia malayi A-macroglobulin complement component family protein 0.0034 0.0041 0.0082
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.017 0.0612 0.0593
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0091 0.028 0.0261
Echinococcus granulosus rhodopsin orphan GPCR 0.034 0.1327 0.131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0062 0.0156 0.0417
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0114 0.0377 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.0743
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0062 0.0156 0.0497
Echinococcus multilocularis transient receptor potential cation channel 0.0091 0.028 0.0261
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0091 0.028 0.0385
Brugia malayi hypothetical protein 0.0033 0.0034 0.0062
Echinococcus multilocularis cd109 antigen 0.0032 0.0031 0.0012
Loa Loa (eye worm) hypothetical protein 0.0119 0.0398 0.1061
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Echinococcus multilocularis SWI:SNF matrix associated 0.0042 0.0076 0.0057
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0042 0.0073 0.0053
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0156 0.0389
Echinococcus multilocularis neuropeptide FF receptor 2 0.034 0.1327 0.131
Echinococcus granulosus rhodopsin orphan GPCR 0.034 0.1327 0.131
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0091 0.028 0.072
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0091 0.0278 0.0743
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0073 0.0595
Echinococcus granulosus potassium voltage gated channel protein 0.0091 0.028 0.0261
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0062 0.0156 0.0137
Echinococcus granulosus voltage gated potassium channel 0.0091 0.028 0.0261
Toxoplasma gondii subtilisin SUB12 0.0128 0.0434 0.0627
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0042 0.0076 0.038
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0219 0.059
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0052
Echinococcus granulosus hyperpolarization activated cyclic 0.0091 0.028 0.0261
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0398 0.1116
Loa Loa (eye worm) hypothetical protein 0.0042 0.0073 0.0194
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0398 0.1116
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0052
Echinococcus multilocularis sodium channel protein 0.1186 0.489 0.488
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.013 0.0111
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Echinococcus granulosus rhodopsin orphan GPCR 0.034 0.1327 0.131
Onchocerca volvulus 0.0119 0.0398 0.1374
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0091 0.028 0.0261
Loa Loa (eye worm) hypothetical protein 0.0111 0.0364 0.0973
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.017 0.0612 0.0593
Echinococcus granulosus shaker cognate 0.0091 0.028 0.0261
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0202 0.0747 1
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Schistosoma mansoni calcium-activated potassium channel 0.0091 0.028 0.077
Trypanosoma cruzi aurora B kinase, putative 0.0114 0.0377 0.4508
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0091 0.028 0.0261
Echinococcus multilocularis alpha 2 macroglobulin 0.0034 0.0041 0.0022
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0079 0.006
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0091 0.0278 0.0259
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0042 0.0073 0.0165
Toxoplasma gondii transporter, cation channel family protein 0.0091 0.028 0.0385
Onchocerca volvulus 0.006 0.0152 0.0481
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0034 0.0043
Schistosoma mansoni voltage-gated potassium channel 0.0091 0.028 0.077
Loa Loa (eye worm) hypothetical protein 0.0062 0.0156 0.0417
Echinococcus multilocularis neuropeptide receptor 0.034 0.1327 0.131
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0219 0.059
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0062 0.0156 0.0137
Echinococcus granulosus short transient receptor potential channel 6 0.0091 0.028 0.0261
Toxoplasma gondii hypothetical protein 0.0091 0.028 0.0385
Echinococcus granulosus glycoprotein Antigen 5 0.0119 0.0398 0.0379
Toxoplasma gondii microneme protein, putative 0.0128 0.0434 0.0627
Loa Loa (eye worm) hypothetical protein 0.0042 0.0073 0.0194
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Brugia malayi neuropeptide F receptor 0.034 0.1327 0.3523
Echinococcus multilocularis G-protein coupled receptor, putative 0.034 0.1327 0.131
Echinococcus granulosus sex peptide receptor 0.034 0.1327 0.131
Echinococcus granulosus transient receptor potential cation channel 0.0091 0.028 0.0261
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Toxoplasma gondii hypothetical protein 0.0128 0.0434 0.0627
Brugia malayi Kelch motif family protein 0.0158 0.0561 0.1473
Loa Loa (eye worm) steroid hormone receptor 0.0062 0.0156 0.0417
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0042 0.0073 0.0194
Echinococcus multilocularis rhodopsin orphan GPCR 0.034 0.1327 0.131
Loa Loa (eye worm) A-macroglobulin complement component family protein 0.0034 0.0041 0.0111
Schistosoma mansoni nAChR subunit 0.0091 0.0278 0.0764
Brugia malayi nuclear receptor NHR-88 0.0029 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Schistosoma mansoni nuclear hormone receptor 0.0062 0.0156 0.0404
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.0743
Schistosoma mansoni peptide (allatostatin)-like receptor 0.034 0.1327 0.386
Onchocerca volvulus 0.0128 0.0434 0.1508
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0062 0.0156 0.0137
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0114 0.0377 1
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0091 0.028 0.3075
Schistosoma mansoni hypothetical protein 0.006 0.0152 0.0391
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0049 0.0103 0.0246
Onchocerca volvulus 0.0033 0.0035 0.0055
Schistosoma mansoni integrin alpha-ps 0.0143 0.0499 0.1415
Loa Loa (eye worm) hypothetical protein 0.0049 0.0103 0.0274
Echinococcus multilocularis short transient receptor potential channel 6 0.0091 0.028 0.0261
Echinococcus multilocularis dro:myosuppressin receptor 0.034 0.1327 0.131
Echinococcus multilocularis potassium voltage gated channel protein 0.0091 0.028 0.0261
Loa Loa (eye worm) LGC-31 protein 0.0091 0.0278 0.0743
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0128 0.0434 0.0627
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0091 0.0278 0.0743
Echinococcus granulosus microtubule associated protein 2 0.0833 0.3407 0.3394
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0091 0.0278 0.0259
Schistosoma mansoni histamine h1 receptor 0.034 0.1327 0.386
Echinococcus multilocularis neuropeptide s receptor 0.034 0.1327 0.131
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.034 0.1327 0.386
Onchocerca volvulus 0.0119 0.0398 0.1374
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0091 0.028 0.072
Loa Loa (eye worm) acetyltransferase 0.0147 0.0517 0.1379
Brugia malayi Cyclic-nucleotide gated cation channel 0.0091 0.028 0.072
Brugia malayi G-protein coupled receptor 0.034 0.1327 0.3523
Onchocerca volvulus Bile acid receptor homolog 0.0062 0.0156 0.0497
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0073 0.0595
Toxoplasma gondii hypothetical protein 0.0111 0.0364 0.0517
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0091 0.028 0.0261
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0091 0.028 0.0261
Schistosoma mansoni hypothetical protein 0.0031 0.0029 0.003
Schistosoma mansoni voltage-gated potassium channel 0.0091 0.028 0.077
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0219 0.02
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Loa Loa (eye worm) hypothetical protein 0.0111 0.0364 0.0973
Echinococcus granulosus potassium voltage gated channel protein 0.0091 0.028 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0062 0.0156 0.0389
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0091 0.028 0.0261
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.0156 0.0404
Loa Loa (eye worm) DR-78 0.0029 0.0019 0.0052
Echinococcus granulosus TRP transient receptor potential channel 0.0091 0.028 0.0261
Loa Loa (eye worm) hypothetical protein 0.0062 0.0156 0.0417
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0042 0.0076 0.038
Brugia malayi Serotonin/octopamine receptor family protein 7 0.034 0.1327 0.3523
Toxoplasma gondii transporter, cation channel family protein 0.0202 0.0747 0.1117
Echinococcus multilocularis potassium voltage gated channel protein 0.0091 0.028 0.0261
Brugia malayi hypothetical protein 0.034 0.1327 0.3523
Schistosoma mansoni hypothetical protein 0.0068 0.0183 0.0483
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0029 0.0049
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0073 0.0053
Brugia malayi Melatonin receptor type 1A 0.034 0.1327 0.3523
Schistosoma mansoni neuropeptide F-like receptor 0.034 0.1327 0.386
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0091 0.028 0.077
Schistosoma mansoni biogenic amine (dopamine) receptor 0.034 0.1327 0.386
Brugia malayi ORL1-like opioid receptor 0.034 0.1327 0.3523
Echinococcus multilocularis transient receptor potential cation channel 0.0091 0.028 0.0261
Loa Loa (eye worm) PAN domain-containing protein 0.0128 0.0434 0.116
Trypanosoma brucei aurora B kinase 0.0114 0.0377 0.4835
Echinococcus granulosus enteropeptidase 0.0119 0.0398 0.0379
Onchocerca volvulus 0.0058 0.0142 0.0447
Loa Loa (eye worm) G-protein coupled receptor 0.034 0.1327 0.3542
Onchocerca volvulus 0.0683 0.2773 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0073 0.0194
Brugia malayi follicle stimulating hormone receptor 0.034 0.1327 0.3523
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.034 0.1327 0.386
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0052
Schistosoma mansoni hypothetical protein 0.034 0.1327 0.386
Loa Loa (eye worm) hypothetical protein 0.0176 0.0637 0.1701
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Brugia malayi Cation transporter family protein 0.0091 0.0278 0.0716
Loa Loa (eye worm) hypothetical protein 0.0042 0.0073 0.0194
Echinococcus multilocularis transient receptor potential gamma protein 0.0091 0.028 0.0261
Brugia malayi Trypsin family protein 0.0683 0.2773 0.7392
Echinococcus granulosus neuropeptides capa receptor 0.034 0.1327 0.131
Echinococcus granulosus dro:myosuppressin receptor 0.034 0.1327 0.131
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0398 0.1116
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0315 0.0842
Loa Loa (eye worm) hypothetical protein 0.0287 0.1106 0.2953
Brugia malayi hypothetical protein 0.0286 0.11 0.2915
Echinococcus granulosus g-protein coupled receptor 0.034 0.1327 0.131
Schistosoma mansoni amine GPCR 0.034 0.1327 0.386
Schistosoma mansoni biogenic amine (dopamine) receptor 0.034 0.1327 0.386
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0091 0.0278 0.0716
Echinococcus granulosus hyperpolarization activated cyclic 0.0091 0.028 0.0261
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0029
Plasmodium falciparum serine/threonine protein kinase, putative 0.0114 0.0377 1
Brugia malayi Integrin alpha pat-2 precursor 0.0319 0.1239 0.3287
Brugia malayi ecdysteroid receptor 0.0062 0.0156 0.0389
Echinococcus multilocularis integrin alpha ps 0.0068 0.0185 0.0166
Loa Loa (eye worm) hypothetical protein 0.0128 0.0434 0.116
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0062 0.0156 0.0137
Onchocerca volvulus 0.0287 0.1106 0.3948
Echinococcus multilocularis FTZ F1 alpha 0.0062 0.0156 0.0137
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0156 0.0389
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0073 0.0595
Echinococcus multilocularis SWI:SNF matrix associated 0.0042 0.0076 0.0057
Echinococcus multilocularis g protein coupled receptor 0.034 0.1327 0.131
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0091 0.028 0.0947
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0091 0.0278 0.0716
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.0743
Schistosoma mansoni rhodopsin-like orphan GPCR 0.034 0.1327 0.386
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0114 0.0377 0.0358
Echinococcus multilocularis rhodopsin orphan GPCR 0.034 0.1327 0.131
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.013 0.0326
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0062 0.0156 0.0417
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0042 0.0073 0.0165
Loa Loa (eye worm) PAN domain-containing protein 0.0128 0.0434 0.116
Brugia malayi putative neuropeptide receptor 0.034 0.1327 0.3523
Loa Loa (eye worm) RNA binding protein 0.0076 0.0219 0.0585
Schistosoma mansoni amine GPCR 0.034 0.1327 0.386
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.034 0.1327 0.131
Echinococcus granulosus serotonin receptor 0.034 0.1327 0.131
Brugia malayi hypothetical protein 0.0029 0.0019 0.0023
Echinococcus multilocularis neuropeptide receptor 0.034 0.1327 0.131
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0091 0.028 0.077
Echinococcus multilocularis integrin beta 2 0.075 0.3058 0.3044
Echinococcus multilocularis g protein coupled receptor 0.034 0.1327 0.131
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0091 0.0278 0.0743
Onchocerca volvulus 0.0056 0.0133 0.0414
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.013 0.0326
Schistosoma mansoni hypothetical protein 0.0031 0.0029 0.003
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Loa Loa (eye worm) hypothetical protein 0.0049 0.0103 0.0274
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0114 0.0377 0.0358
Schistosoma mansoni voltage-gated potassium channel 0.0091 0.028 0.077
Loa Loa (eye worm) ryanodine receptor 0.0091 0.028 0.0748
Echinococcus granulosus potassium voltage gated channel protein 0.0091 0.028 0.0261
Loa Loa (eye worm) hypothetical protein 0.0049 0.0103 0.0274
Brugia malayi hypothetical protein 0.0042 0.0073 0.0165
Schistosoma mansoni ephrin receptor 0.0067 0.0181 0.0476
Brugia malayi GnHR receptor homolog 0.079 0.3222 0.8596
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0091 0.028 0.072
Loa Loa (eye worm) hypothetical protein 0.0062 0.0156 0.0417
Echinococcus multilocularis neuropeptide receptor A26 0.034 0.1327 0.131
Brugia malayi ecdysone receptor 0.0029 0.0019 0.0023
Echinococcus granulosus aurora kinase A 0.0114 0.0377 0.0358
Loa Loa (eye worm) calcium channel 0.0202 0.0747 0.1995
Loa Loa (eye worm) hypothetical protein 0.0128 0.0434 0.116
Onchocerca volvulus 0.0049 0.0103 0.0303
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0091 0.0278 0.0716
Toxoplasma gondii PAN domain-containing protein 0.0128 0.0434 0.0627
Brugia malayi PAN domain containing protein 0.0128 0.0434 0.1134
Echinococcus multilocularis serotonin receptor 0.034 0.1327 0.131
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0091 0.0278 0.0259
Brugia malayi hypothetical protein 0.0119 0.0398 0.1035
Brugia malayi hypothetical protein 0.0042 0.0073 0.0165
Brugia malayi excitatory GABA receptor EXP-1A 0.0091 0.0278 0.0716
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0073 0.0595
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0202 0.0747 0.0729
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0044 0.0202
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0042 0.0073 0.0053
Loa Loa (eye worm) hypothetical protein 0.0033 0.0035 0.0092
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0091 0.0278 0.0716
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0091 0.028 0.0261
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.0499 0.0481
Schistosoma mansoni rhodopsin-like orphan GPCR 0.034 0.1327 0.386
Trichomonas vaginalis AGC family protein kinase 0.0114 0.0377 1
Brugia malayi EGF-like domain containing protein 0.0033 0.0035 0.0063
Echinococcus granulosus peptide allatostatin:somatostatin 0.034 0.1327 0.131
Brugia malayi Dopamine receptor protein 2 0.034 0.1327 0.3523
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0091 0.028 0.0748
Loa Loa (eye worm) hypothetical protein 0.0042 0.0073 0.0194
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.0019 0.0052
Loa Loa (eye worm) hypothetical protein 0.0062 0.0156 0.0417
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0156 0.0389
Loa Loa (eye worm) hypothetical protein 0.017 0.0612 0.1632
Schistosoma mansoni nAChR subunit 0.0091 0.0278 0.0764
Brugia malayi hypothetical protein 0.034 0.1327 0.3523
Schistosoma mansoni nAChR subunit 0.0042 0.0073 0.0157
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0119 0.0398 0.1116
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.0743
Echinococcus multilocularis calcium activated potassium channel 0.0092 0.0284 0.0265
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0164 0.0587 0.1566
Schistosoma mansoni amine GPCR 0.034 0.1327 0.386
Loa Loa (eye worm) hypothetical protein 0.006 0.0152 0.0405
Schistosoma mansoni neurotransmitter gated ion channel 0.0049 0.0103 0.0246
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0034 0.0015
Onchocerca volvulus 0.034 0.1327 0.475
Brugia malayi neuropeptide F receptor 0.034 0.1327 0.3523
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0091 0.028 0.077
Entamoeba histolytica protein kinase , putative 0.0114 0.0377 1
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Brugia malayi Trypsin family protein 0.0119 0.0398 0.1035
Echinococcus granulosus voltage dependent calcium channel 0.0202 0.0747 0.0729
Brugia malayi RNA binding protein 0.0076 0.0219 0.0558
Echinococcus multilocularis glycoprotein Antigen 5 0.0119 0.0398 0.0379
Brugia malayi brahma associated protein 60 kDa 0.0042 0.0076 0.0174
Echinococcus multilocularis allatostatin A receptor 0.034 0.1327 0.131
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.017 0.0612 0.1608
Leishmania major hypothetical protein, conserved 0.0091 0.028 0.0271
Echinococcus granulosus glycine receptor subunit alpha 1 0.0091 0.0278 0.0259
Echinococcus multilocularis fmrfamide receptor 0.034 0.1327 0.131
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0219 0.0585
Echinococcus multilocularis protein jagged 2 0.0033 0.0035 0.0015
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0123 0.0414 0.1164
Loa Loa (eye worm) hypothetical protein 0.025 0.0951 0.2537
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Schistosoma mansoni rhodopsin-like orphan GPCR 0.034 0.1327 0.386
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0219 0.059
Echinococcus granulosus biogenic amine 5HT receptor 0.034 0.1327 0.131
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0219 0.059
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.034 0.1327 0.3542
Schistosoma mansoni voltage-gated potassium channel 0.0091 0.028 0.077
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.013 0.0346
Loa Loa (eye worm) hypothetical protein 0.0033 0.0035 0.0092
Echinococcus multilocularis g-protein coupled receptor 0.034 0.1327 0.131
Echinococcus multilocularis fibrillin 2 0.0033 0.0035 0.0015
Brugia malayi larval opioid receptor 0.034 0.1327 0.3523
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0062 0.0156 0.0389
Loa Loa (eye worm) trypsin family protein 0.0119 0.0398 0.1061
Loa Loa (eye worm) hypothetical protein 0.0049 0.0103 0.0274
Loa Loa (eye worm) hypothetical protein 0.0128 0.0434 0.116
Brugia malayi PAN domain containing protein 0.0128 0.0434 0.1134
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0156 0.0404
Toxoplasma gondii PAN domain-containing protein 0.1548 0.6415 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0091 0.0278 0.0764
Brugia malayi SWIB/MDM2 domain containing protein 0.0042 0.0076 0.0174
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0029 0.001
Brugia malayi hypothetical protein 0.034 0.1327 0.3523
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.034 0.1327 0.131
Brugia malayi hypothetical protein 0.034 0.1327 0.3523
Trichomonas vaginalis AGC family protein kinase 0.0114 0.0377 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.034 0.1327 0.3523
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0042 0.0073 0.0053
Echinococcus granulosus neuropeptide FF receptor 2 0.034 0.1327 0.131
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0091 0.0278 0.0716
Echinococcus granulosus hypothetical protein 0.0091 0.028 0.0261
Schistosoma mansoni serine-type protease inhibitor 0.0446 0.1775 0.5184
Echinococcus granulosus tachykinin peptides receptor 99D 0.034 0.1327 0.131
Brugia malayi serine/threonine kinase 12 0.0114 0.0377 0.0979
Echinococcus granulosus potassium voltage gated channel protein 0.0091 0.028 0.0261
Loa Loa (eye worm) neuropeptide F receptor 0.034 0.1327 0.3542
Schistosoma mansoni transient receptor potential channel 0.0091 0.028 0.077
Brugia malayi G protein-coupled receptor 0.034 0.1327 0.3523
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0091 0.028 0.0261
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.0743
Loa Loa (eye worm) hypothetical protein 0.0683 0.2773 0.74
Echinococcus granulosus neuropeptide receptor 0.034 0.1327 0.131
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0034 0.0062
Schistosoma mansoni nAChR subunit 0.0091 0.0278 0.0764
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Echinococcus granulosus allatostatin A receptor 0.034 0.1327 0.131
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Echinococcus multilocularis neuropeptide Y receptor 0.034 0.1327 0.131
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0073 0.0595
Loa Loa (eye worm) TYRA-2 protein 0.034 0.1327 0.3542
Schistosoma mansoni vesicular amine transporter 0.0091 0.028 0.077
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.034 0.1327 0.386
Brugia malayi hypothetical protein 0.034 0.1327 0.3523
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.034 0.1327 0.131
Echinococcus granulosus fibrillin 2 0.0033 0.0035 0.0015
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0062 0.0156 0.0137
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0073 0.111
Onchocerca volvulus 0.0042 0.0073 0.0194
Leishmania major protein kinase, putative 0.0114 0.0377 0.0475
Schistosoma mansoni voltage-gated potassium channel 0.0091 0.028 0.077
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0034 0.0038 0.0056
Echinococcus granulosus voltage gated potassium channel 0.0091 0.028 0.0261
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.0743
Loa Loa (eye worm) hypothetical protein 0.0074 0.021 0.0561
Schistosoma mansoni voltage-gated potassium channel 0.0091 0.028 0.077
Brugia malayi Cation transporter family protein 0.0287 0.1106 0.2932
Schistosoma mansoni biogenic amine receptor 0.034 0.1327 0.386
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0042 0.0073 0.0194
Brugia malayi cation channel family protein 0.0091 0.028 0.072
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0052
Onchocerca volvulus 0.0128 0.0434 0.1508
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Echinococcus multilocularis rhodopsin orphan GPCR 0.034 0.1327 0.131
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0062 0.0156 0.0404
Brugia malayi Trypsin-like protease protein 5 0.0119 0.0398 0.1035
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0019 0.0023
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0029 0.001
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Onchocerca volvulus 0.034 0.1327 0.475
Echinococcus multilocularis orexin receptor type 2 0.034 0.1327 0.131
Entamoeba histolytica protein kinase, putative 0.0114 0.0377 1
Echinococcus granulosus potassium voltage gated channel protein 0.0091 0.028 0.0261
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Loa Loa (eye worm) AUR protein kinase 0.0114 0.0377 0.1006
Echinococcus granulosus somatostatin receptor 0.034 0.1327 0.131
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0091 0.0278 0.0716
Loa Loa (eye worm) hypothetical protein 0.0128 0.0434 0.116
Schistosoma mansoni voltage-gated potassium channel 0.0091 0.028 0.077
Echinococcus granulosus nAChR subunit 0.0049 0.0103 0.0083
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.034 0.1327 0.3523
Echinococcus multilocularis potassium voltage gated channel protein 0.0091 0.028 0.0261
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Onchocerca volvulus 0.034 0.1327 0.475
Echinococcus multilocularis enteropeptidase 0.0119 0.0398 0.0379
Schistosoma mansoni voltage-gated potassium channel 0.0091 0.028 0.077
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0029 0.001
Brugia malayi hypothetical protein 0.0029 0.0019 0.0023
Toxoplasma gondii hypothetical protein 0.0091 0.028 0.0385
Brugia malayi nuclear receptor RXR 0.0029 0.0019 0.0023
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0091 0.028 0.077
Schistosoma mansoni nAChR subunit 0.0042 0.0073 0.0157
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0152 0.1175
Echinococcus granulosus FTZ F1 alpha 0.0062 0.0156 0.0137
Brugia malayi conserved hypotetical protein 0.0029 0.0019 0.0023
Schistosoma mansoni voltage-gated potassium channel 0.0091 0.028 0.077
Echinococcus granulosus ryanodine receptor 44f 0.0091 0.028 0.0261
Brugia malayi Angiotensin-converting enzyme family protein 0.0164 0.0587 0.1541
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.034 0.1327 0.131
Onchocerca volvulus 0.0042 0.0076 0.0206
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.0743
Loa Loa (eye worm) integrin alpha pat-2 0.0491 0.1965 0.5246
Loa Loa (eye worm) hypothetical protein 0.0119 0.0398 0.1061
Echinococcus multilocularis sodium leak channel non selective protein 0.0091 0.028 0.0261
Brugia malayi nuclear receptor NHR-67 0.0029 0.0019 0.0023
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.0517 0.1467
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0091 0.0278 0.0259
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.034 0.1327 0.131
Loa Loa (eye worm) hypothetical protein 0.0033 0.0034 0.0091
Schistosoma mansoni alpha-1 adrenergic receptor 0.034 0.1327 0.386
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0073 0.0595
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Echinococcus granulosus integrin alpha ps 0.0143 0.0499 0.048
Echinococcus granulosus glycine receptor subunit alpha 1 0.0091 0.0278 0.0259
Schistosoma mansoni hypothetical protein 0.0119 0.0398 0.1116
Echinococcus multilocularis nAChR subunit 0.0091 0.0278 0.0259
Onchocerca volvulus 0.0091 0.0278 0.094
Schistosoma mansoni transient receptor potential channel 0.0091 0.028 0.077
Loa Loa (eye worm) brahma associated protein 0.0042 0.0076 0.0203
Echinococcus granulosus transient receptor potential cation channel 0.0091 0.028 0.0261
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0398 0.1116
Echinococcus granulosus voltage gated hydrogen channel 1 0.0091 0.028 0.0261
Brugia malayi AKH receptor 0.034 0.1327 0.3523
Loa Loa (eye worm) hypothetical protein 0.0042 0.0073 0.0194
Onchocerca volvulus 0.0128 0.0434 0.1508
Echinococcus multilocularis ecdysone induced protein 78C 0.0062 0.0156 0.0137
Toxoplasma gondii hypothetical protein 0.0128 0.0434 0.0627
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0062 0.0156 0.0389
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0091 0.0278 0.0259
Brugia malayi serine/threonine protein kinase 6 0.0114 0.0377 0.0979
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0091 0.0278 0.0716
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.11 0.1082
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Brugia malayi EGF-like domain containing protein 0.0033 0.0035 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.034 0.1327 0.386
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.017 0.0612 0.0593
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0042 0.0076 0.0065
Onchocerca volvulus 0.0062 0.0156 0.0497
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0091 0.028 0.0385
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0119 0.0398 0.1116
Brugia malayi RE15519p 0.034 0.1327 0.3523
Schistosoma mansoni rhodopsin-like orphan GPCR 0.034 0.1327 0.386
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0062 0.0156 0.0404
Onchocerca volvulus 0.0128 0.0434 0.1508
Loa Loa (eye worm) ACC-1 protein 0.0091 0.0278 0.0743
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Brugia malayi EGF-like domain containing protein 0.0033 0.0035 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0073 0.0595
Echinococcus multilocularis aurora kinase A 0.0114 0.0377 0.0358
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0091 0.028 0.7173
Loa Loa (eye worm) hypothetical protein 0.0033 0.0035 0.0092
Loa Loa (eye worm) hypothetical protein 0.0068 0.0183 0.0488
Echinococcus multilocularis G protein coupled receptor 139 0.034 0.1327 0.131
Schistosoma mansoni neuropeptide f receptor 76f 0.034 0.1327 0.386
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.034 0.1327 0.131
Schistosoma mansoni survival motor neuron protein 0.0058 0.0142 0.0363
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0091 0.0278 0.0259
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.034 0.1327 0.475
Schistosoma mansoni integrin alpha-ps 0.0074 0.021 0.0564
Loa Loa (eye worm) hypothetical protein 0.0033 0.0035 0.0092
Echinococcus multilocularis integrin alpha 3 0.0244 0.0926 0.0908
Echinococcus multilocularis nAChR subunit 0.0049 0.0103 0.0083
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Schistosoma mansoni amine GPCR 0.034 0.1327 0.386
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0042 0.0073 0.0165
Echinococcus multilocularis hyperpolarization activated cyclic 0.0091 0.028 0.0261
Onchocerca volvulus 0.0128 0.0434 0.1508
Loa Loa (eye worm) hypothetical protein 0.0062 0.0156 0.0417
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Brugia malayi gonadotropin-releasing hormone receptor 2 0.034 0.1327 0.3523
Brugia malayi Protein kinase domain containing protein 0.0061 0.0155 0.0386
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.034 0.1327 0.386
Schistosoma mansoni brg-1 associated factor 0.0042 0.0076 0.0167
Echinococcus granulosus g protein coupled receptor 0.034 0.1327 0.131
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Leishmania major hypothetical protein, unknown function 0.0091 0.028 0.0271
Loa Loa (eye worm) hypothetical protein 0.0119 0.0398 0.1061
Echinococcus granulosus ecdysone induced protein 78C 0.0062 0.0156 0.0137
Schistosoma mansoni voltage-dependent calcium channel 0.0091 0.028 0.077
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0683 0.2773 0.8127
Echinococcus granulosus glycine receptor subunit beta 0.0091 0.0278 0.0259
Brugia malayi PAN domain containing protein 0.0128 0.0434 0.1134
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0119 0.0398 0.1035
Onchocerca volvulus 0.0287 0.1106 0.3948
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Toxoplasma gondii kringle domain-containing protein 0.006 0.0152 0.0184
Echinococcus multilocularis integrin alpha ps 0.0143 0.0499 0.048
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.034 0.1327 0.131
Loa Loa (eye worm) integrin beta-2 0.0914 0.3747 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0202 0.0747 0.0729
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0062 0.0156 0.0417
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0034 0.0043
Loa Loa (eye worm) hypothetical protein 0.0119 0.0398 0.1061
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.0743
Schistosoma mansoni macroglobulin/complement 0.0034 0.0041 0.0065
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Trichomonas vaginalis AGC family protein kinase 0.0114 0.0377 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0079 0.1305
Brugia malayi PAN domain containing protein 0.0128 0.0434 0.1134
Loa Loa (eye worm) voltage-dependent calcium channel 0.0202 0.0747 0.1995
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0091 0.0278 0.0716
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Echinococcus granulosus integrin beta 2 0.075 0.3058 0.3044
Schistosoma mansoni hypothetical protein 0.0042 0.0076 0.0167
Echinococcus multilocularis transient receptor potential cation channel 0.0091 0.028 0.0261
Echinococcus multilocularis voltage dependent calcium channel 0.0202 0.0747 0.0729
Brugia malayi ion channel NompC 0.0091 0.028 0.072
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.034 0.1327 0.3542
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.008
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.017 0.0612 0.0593
Entamoeba histolytica protein kinase, putative 0.0114 0.0377 1
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0019 0.0023
Onchocerca volvulus Putative nachr subunit 0.017 0.0612 0.2151
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0398 0.1116
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0091 0.028 0.0748
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0287 0.1106 0.3209
Echinococcus granulosus nAChR subunit 0.0091 0.0278 0.0259
Onchocerca volvulus 0.034 0.1327 0.475
Echinococcus granulosus thyrotropin releasing hormone receptor 0.034 0.1327 0.131
Onchocerca volvulus 0.0128 0.0434 0.1508
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0062 0.0156 0.0389
Brugia malayi Serotonin receptor 0.034 0.1327 0.3523
Loa Loa (eye worm) hypothetical protein 0.0033 0.0034 0.0091
Schistosoma mansoni integrin alpha 0.0319 0.1239 0.36
Schistosoma mansoni neuropeptide receptor 0.034 0.1327 0.386
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0142 0.0352
Brugia malayi Kringle domain containing protein 0.006 0.0152 0.0377
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0052
Schistosoma mansoni myosin xvIII 0.034 0.1327 0.386
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0091 0.0278 0.0259
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0079 0.007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.034 0.1327 0.386
Loa Loa (eye worm) hypothetical protein 0.0033 0.0034 0.0091
Onchocerca volvulus 0.0119 0.0398 0.1374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0062 0.0156 0.0417
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0091 0.028 0.077
Echinococcus granulosus transient receptor potential cation channel 0.0091 0.028 0.0261
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0287 0.1106 0.3209
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0119 0.0398 0.0379
Onchocerca volvulus 0.0042 0.0073 0.0194
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.034 0.1327 0.3542
Schistosoma mansoni adenoreceptor 0.034 0.1327 0.386
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0114 0.0377 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0062 0.0156 0.0404
Onchocerca volvulus 0.0128 0.0434 0.1508
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0156 0.0389
Trypanosoma brucei unspecified product 0.0035 0.0044 0.0202
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0042 0.0076 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0062 0.0156 0.0389
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0019 0.0023
Echinococcus granulosus tm gpcr rhodopsin 0.034 0.1327 0.131
Brugia malayi hypothetical protein 0.034 0.1327 0.3523
Loa Loa (eye worm) hypothetical protein 0.0287 0.1106 0.2953
Onchocerca volvulus 0.0049 0.0103 0.0303
Loa Loa (eye worm) acetylcholine receptor protein 0.0042 0.0073 0.0194
Onchocerca volvulus 0.0042 0.0076 0.0205
Echinococcus granulosus sodium channel protein 0.1186 0.489 0.488
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0049 0.0103 0.0246
Schistosoma mansoni hypothetical protein 0.0091 0.028 0.077
Echinococcus granulosus 7tm_1 domain containing protein 0.034 0.1327 0.131
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0119 0.0398 0.1116
Onchocerca volvulus 0.0564 0.2272 0.8182
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0052
Loa Loa (eye worm) hypothetical protein 0.0049 0.0103 0.0274
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.013 0.0326
Echinococcus granulosus calcium activated potassium channel 0.0092 0.0284 0.0265
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0114 0.0377 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0315 0.0815
Loa Loa (eye worm) TK/ROR protein kinase 0.0061 0.0155 0.0414
Echinococcus multilocularis rhodopsin orphan GPCR 0.034 0.1327 0.131
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0052
Brugia malayi hypothetical protein 0.0033 0.0034 0.0062
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.034 0.1327 0.131
Echinococcus granulosus neuropeptide Y receptor 0.034 0.1327 0.131
Echinococcus granulosus g protein coupled receptor 0.034 0.1327 0.131
Onchocerca volvulus 0.0128 0.0434 0.1508
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0119 0.0398 0.1116
Onchocerca volvulus 0.034 0.1327 0.475
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.034 0.1327 0.131
Schistosoma mansoni acetylcholine receptor subunit beta 0.0042 0.0073 0.0157
Loa Loa (eye worm) voltage-gated potassium channel 0.0091 0.028 0.0748
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0219 0.0558
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0091 0.0278 0.0716
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0695 0.2826 0.8286
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.0743
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0042 0.0076 0.0065
Mycobacterium ulcerans hypothetical protein 0.0119 0.0398 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2399 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.034 0.1327 0.3542
Schistosoma mansoni voltage-gated cation channel 0.0202 0.0747 0.2149
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0091 0.0278 0.0716
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.0743
Loa Loa (eye worm) hypothetical protein 0.0042 0.0073 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0073 0.0595
Echinococcus multilocularis conserved hypothetical protein 0.0091 0.028 0.0261
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0202 0.0747 0.1971
Onchocerca volvulus 0.034 0.1327 0.475
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.013 0.0318
Loa Loa (eye worm) hypothetical protein 0.0062 0.0156 0.0417
Echinococcus multilocularis transmembrane protease serine 3 0.0119 0.0398 0.0379
Brugia malayi Transient-receptor-potential like protein 0.0091 0.028 0.072
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0202 0.0747 0.2149
Loa Loa (eye worm) hypothetical protein 0.0062 0.0156 0.0417
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0042 0.0073 0.0165
Schistosoma mansoni biogenic amine (dopamine) receptor 0.034 0.1327 0.386
Schistosoma mansoni two-pore calcium channel 0.0091 0.028 0.077
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0091 0.028 0.077
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Schistosoma mansoni integrin beta subunit 0.0597 0.2409 0.7056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0062 0.0156 0.0417
Brugia malayi tailless protein 0.0029 0.0019 0.0023
Brugia malayi PAN domain containing protein 0.0128 0.0434 0.1134
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0156 0.0137
Echinococcus granulosus potassium large conductance calcium activated 0.0091 0.028 0.0261
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0029 0.001
Brugia malayi nuclear hormone receptor 0.0029 0.0019 0.0023
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0091 0.0278 0.0716
Loa Loa (eye worm) hypothetical protein 0.0128 0.0434 0.116
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.013 0.0111
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0091 0.028 0.077
Toxoplasma gondii microneme protein MIC17C 0.0128 0.0434 0.0627
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0091 0.0278 0.0764
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0091 0.028 0.072
Toxoplasma gondii PAN/Apple domain-containing protein 0.0128 0.0434 0.0627
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.0743
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0377 0.1055
Loa Loa (eye worm) neuropeptide F receptor 0.034 0.1327 0.3542
Loa Loa (eye worm) GABA receptor subunit 0.0049 0.0103 0.0274
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0091 0.028 0.0261
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0019 0.0023
Echinococcus granulosus GPCR family 2 0.0031 0.0029 0.001
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0091 0.028 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0156 0.0389
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0042 0.0076 0.0203
Schistosoma mansoni voltage-gated potassium channel 0.0091 0.028 0.077
Onchocerca volvulus 0.0042 0.0073 0.0194
Loa Loa (eye worm) hypothetical protein 0.0245 0.0931 0.2484
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0091 0.028 0.3487
Brugia malayi polk-prov protein 0.0032 0.003 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0219 0.059
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0158 0.0561 0.1498
Schistosoma mansoni protein kinase 0.0114 0.0377 0.1055
Echinococcus granulosus transient receptor potential cation channel 0.0091 0.028 0.0261
Onchocerca volvulus Neuropeptide F receptor homolog 0.034 0.1327 0.475
Loa Loa (eye worm) hypothetical protein 0.0286 0.11 0.2935
Echinococcus multilocularis g protein coupled receptor 0.034 0.1327 0.131
Echinococcus multilocularis rhodopsin orphan GPCR 0.034 0.1327 0.131
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0042 0.0073 0.0053
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0052
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0091 0.028 0.0261
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0079 0.1305
Echinococcus multilocularis transfer RNA-Gly 0.0091 0.028 0.0261
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0398 0.1116
Schistosoma mansoni neuropeptide receptor 0.034 0.1327 0.386
Echinococcus multilocularis biogenic amine (5HT) receptor 0.034 0.1327 0.131
Loa Loa (eye worm) hypothetical protein 0.0049 0.0103 0.0274
Toxoplasma gondii microneme protein MIC4 0.0128 0.0434 0.0627
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0156 0.0137
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Loa Loa (eye worm) hypothetical protein 0.0042 0.0073 0.0194
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.034 0.1327 0.131
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0052
Echinococcus multilocularis voltage dependent calcium channel 0.0202 0.0747 0.0729
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0091 0.028 0.077
Echinococcus multilocularis two pore calcium channel protein 2 0.0091 0.028 0.0261
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0062 0.0156 0.0137
Echinococcus granulosus cd109 antigen 0.0032 0.0031 0.0012
Loa Loa (eye worm) hypothetical protein 0.0049 0.0103 0.0274
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0019 0.0052
Loa Loa (eye worm) PAN domain-containing protein 0.0128 0.0434 0.116
Schistosoma mansoni neurotransmitter gated ion channel 0.0042 0.0073 0.0157
Echinococcus granulosus hypothetical protein 0.034 0.1327 0.131
Loa Loa (eye worm) hypothetical protein 0.0067 0.0178 0.0474
Schistosoma mansoni opsin-like receptor 0.034 0.1327 0.386
Brugia malayi hypothetical protein 0.034 0.1327 0.3523
Schistosoma mansoni neurotransmitter gated ion channel 0.0042 0.0073 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0076 0.1208
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0049 0.0103 0.0246
Echinococcus multilocularis potassium large conductance calcium activated 0.0091 0.028 0.0261
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0091 0.0278 0.0743
Echinococcus multilocularis short transient receptor potential channel 6 0.0091 0.028 0.0261
Loa Loa (eye worm) melatonin receptor type 1A 0.034 0.1327 0.3542
Echinococcus granulosus adam 0.0033 0.0035 0.0015
Loa Loa (eye worm) hypothetical protein 0.0062 0.0156 0.0417
Echinococcus granulosus rhodopsin orphan GPCR 0.034 0.1327 0.131
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0091 0.028 0.072
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0091 0.0278 0.0259
Brugia malayi PAN domain containing protein 0.0128 0.0434 0.1134
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0091 0.028 0.0261
Echinococcus multilocularis neuropeptides capa receptor 0.034 0.1327 0.131
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0091 0.028 0.072
Toxoplasma gondii microneme protein MIC17B 0.0128 0.0434 0.0627
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0241 0.0912 0.2412
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0091 0.0278 0.0259
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.034 0.1327 0.386
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0042 0.0073 0.0165
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.017 0.0612 0.1632
Onchocerca volvulus 0.0128 0.0434 0.1508
Echinococcus multilocularis sex peptide receptor 0.034 0.1327 0.131
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.034 0.1327 0.131
Loa Loa (eye worm) hypothetical protein 0.0241 0.0912 0.2434
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Brugia malayi hypothetical protein 0.0042 0.0073 0.0165
Brugia malayi Dopamine receptor protein 1 0.034 0.1327 0.3523
Schistosoma mansoni biogenic amine receptor 0.034 0.1327 0.386
Schistosoma mansoni retinoic acid receptor RXR 0.0062 0.0156 0.0404
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0156 0.0404
Schistosoma mansoni acetylcholine receptor-related 0.0042 0.0073 0.0157
Toxoplasma gondii microneme protein MIC17A 0.0128 0.0434 0.0627
Leishmania major calcium channel protein, putative,ion transporter, putative 0.1186 0.489 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0091 0.0278 0.0764
Schistosoma mansoni hypothetical protein 0.034 0.1327 0.386
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0091 0.028 0.077
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0398 0.1116
Schistosoma mansoni voltage-gated potassium channel 0.0091 0.028 0.077
Brugia malayi Serotonin receptor 0.034 0.1327 0.3523
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0202 0.0747 0.0729
Onchocerca volvulus 0.0128 0.0434 0.1508
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0091 0.028 0.072
Echinococcus multilocularis fibrillin 1 0.0033 0.0035 0.0015
Onchocerca volvulus 0.034 0.1327 0.475
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.034 0.1327 0.131
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Echinococcus multilocularis fmrfamide receptor 0.034 0.1327 0.131
Echinococcus granulosus rhodopsin orphan GPCR 0.034 0.1327 0.131
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.0517 0.0498
Loa Loa (eye worm) PAN domain-containing protein 0.0128 0.0434 0.116
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0062 0.0156 0.0389
Echinococcus granulosus fibrillin 1 0.0033 0.0035 0.0015
Echinococcus granulosus neuropeptides capa receptor 0.034 0.1327 0.131
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0091 0.028 0.072
Brugia malayi brahma associated protein 60 kDa 0.0042 0.0076 0.0174
Echinococcus multilocularis potassium voltage gated channel protein 0.0091 0.028 0.0261
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Brugia malayi hypothetical protein 0.034 0.1327 0.3523
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0091 0.0278 0.0764
Brugia malayi Steroid receptor seven-up type 2 0.0062 0.0156 0.0389
Loa Loa (eye worm) hypothetical protein 0.0154 0.0545 0.1456
Echinococcus granulosus dna polymerase kappa 0.0042 0.0073 0.0053
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Echinococcus granulosus voltage dependent calcium channel 0.0202 0.0747 0.0729
Schistosoma mansoni biogenic amine receptor 0.034 0.1327 0.386
Schistosoma mansoni biogenic amine (5HT) receptor 0.034 0.1327 0.386
Echinococcus multilocularis tachykinin peptides receptor 99D 0.034 0.1327 0.131
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.0743
Echinococcus granulosus Mastin 0.0119 0.0398 0.0379
Onchocerca volvulus 0.034 0.1327 0.475
Onchocerca volvulus 0.034 0.1327 0.475
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0034 0.0091
Plasmodium vivax cysteine repeat modular protein 1, putative 0.006 0.0152 0.2523
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Echinococcus granulosus tissue type plasminogen activator 0.006 0.0152 0.0133
Brugia malayi G-protein coupled receptor 0.034 0.1327 0.3523
Loa Loa (eye worm) hypothetical protein 0.0091 0.028 0.0748
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0119 0.0398 0.1116
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0091 0.028 0.072
Entamoeba histolytica protein kinase domain containing protein 0.0114 0.0377 1
Toxoplasma gondii aurora kinase 0.0114 0.0377 0.0536
Brugia malayi serine/threonine-protein kinase 6 0.0114 0.0377 0.0979
Loa Loa (eye worm) TK/EPH protein kinase 0.0086 0.0258 0.0687
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.013 0.0111
Echinococcus multilocularis rhodopsin orphan GPCR 0.034 0.1327 0.131
Echinococcus granulosus SWI:SNF matrix associated 0.0042 0.0076 0.0057
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0219 0.0585
Echinococcus granulosus ephrin type A receptor 4 A 0.0067 0.0181 0.0162
Echinococcus multilocularis tissue type plasminogen activator 0.006 0.0152 0.0133
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.034 0.1327 0.386
Giardia lamblia Aurora kinase 0.0114 0.0377 1
Echinococcus granulosus integrin alpha ps 0.0068 0.0185 0.0166
Loa Loa (eye worm) voltage-gated potassium channel 0.0091 0.028 0.0748
Brugia malayi hypothetical protein 0.034 0.1327 0.3523
Schistosoma mansoni voltage-gated ion channel 0.0091 0.028 0.077
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.0743
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0091 0.028 0.0261
Loa Loa (eye worm) hypothetical protein 0.0128 0.0434 0.116
Loa Loa (eye worm) hypothetical protein 0.0042 0.0073 0.0194
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.3407 0.3394
Entamoeba histolytica hypothetical protein 0.0049 0.0103 0.1235
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0091 0.028 0.077
Echinococcus granulosus tm gpcr rhodopsin 0.034 0.1327 0.131
Schistosoma mansoni hypothetical protein 0.034 0.1327 0.386
Trichomonas vaginalis AGC family protein kinase 0.0114 0.0377 1
Echinococcus granulosus tar DNA binding protein 0.0076 0.0219 0.02
Echinococcus granulosus rhodopsin orphan GPCR 0.034 0.1327 0.131
Schistosoma mansoni hypothetical protein 0.0058 0.0142 0.0363
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0119 0.0398 0.0379
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0091 0.028 0.0261
Loa Loa (eye worm) hypothetical protein 0.0042 0.0073 0.0194
Echinococcus multilocularis ephrin type A receptor 4 A 0.0067 0.0181 0.0162
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0398 0.1116
Toxoplasma gondii PAN domain-containing protein 0.0128 0.0434 0.0627
Brugia malayi hypothetical protein 0.0154 0.0545 0.1431
Brugia malayi photoreceptor-specific nuclear receptor 0.0062 0.0156 0.0389
Brugia malayi Integrin beta pat-3 precursor 0.0914 0.3747 1
Onchocerca volvulus 0.0287 0.1106 0.3948
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0091 0.0278 0.0743
Brugia malayi cation channel family protein 0.0091 0.028 0.072
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0091 0.0278 0.0259
Echinococcus multilocularis ryanodine receptor 44f 0.0091 0.028 0.0261
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0091 0.028 0.0261
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0091 0.028 0.077
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0091 0.028 0.0261
Brugia malayi PAN domain containing protein 0.0128 0.0434 0.1134
Echinococcus granulosus two pore calcium channel protein 2 0.0091 0.028 0.0261
Loa Loa (eye worm) hypothetical protein 0.034 0.1327 0.3542
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0073 0.0595

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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