TDR Targets

Basic information

Technical information

TDR Targets ID: 1432575
Name: [4-(3,4-dihydro-1H-isoquinolin-2-yl)-5-methyl thieno[5,4-d]pyrimidin-6-yl]-(1,4-dioxa-8-aza spiro[4.5]decan-8-yl)methanone
MW: 450.553 | Formula: C24H26N4O3S
H donors: 0 H acceptors: 3 LogP: 3.65 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1sc2c(c1C)c(ncn2)N1CCc2c(C1)cccc2)N1CCC2(CC1)OCCO2
InChi: 1S/C24H26N4O3S/c1-16-19-21(28-9-6-17-4-2-3-5-18(17)14-28)25-15-26-22(19)32-20(16)23(29)27-10-7-24(8-11-27)30-12-13-31-24/h2-5,15H,6-14H2,1H3
InChiKey: LDKOXAQDVXOAQI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[4-(3,4-dihydro-1H-isoquinolin-2-yl)-5-methyl-thieno[5,4-d]pyrimidin-6-yl]-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone
[4-(3,4-dihydro-1H-isoquinolin-2-yl)-5-methyl-6-thieno[5,4-d]pyrimidinyl]-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone
Oprea1_170887
2-[6-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-5-methylthieno[2,3-d]pyrimidin-4-yl]-1,2,3,4-tetrahydroisoquinoline
MLS000682744
SMR000312101

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	lipase LipD	0.004	0.0342	1
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0366	0.5159
Plasmodium vivax	macrophage migration inhibitory factor, putative	0.0373	0.4081	1
Schistosoma mansoni	hypothetical protein	0.0041	0.036	0.5085
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0342	0.0778
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.0294	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0112	0.0275
Echinococcus multilocularis	cpg binding protein	0.0035	0.0293	0.0287
Trichomonas vaginalis	glucosylceramidase, putative	0.0299	0.3251	0.7782
Entamoeba histolytica	macrophage migration inhibitory factor-like protein	0.0373	0.4081	1
Brugia malayi	Pre-SET motif family protein	0.0241	0.2609	0.6369
Trichomonas vaginalis	glucosylceramidase, putative	0.0299	0.3251	0.7782
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0342	0.0337
Leishmania major	hypothetical protein, conserved	0.004	0.0342	0.0609
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.2098	0.4698
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.2098	0.4698
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0072	0.0704	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.2098	0.4698
Loa Loa (eye worm)	cytochrome P450	0.0018	0.0099	0.0243
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.2098	0.4698
Trichomonas vaginalis	glucosylceramidase, putative	0.0207	0.2217	0.5015
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0112	0.0211
Leishmania major	cytochrome p450-like protein	0.0027	0.0201	0.0255
Trichomonas vaginalis	set domain proteins, putative	0.0275	0.2982	0.7061
Schistosoma mansoni	hypothetical protein	0.0018	0.0099	0.1346
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0342	1
Schistosoma mansoni	cpg binding protein	0.0033	0.0271	0.3809
Loa Loa (eye worm)	hypothetical protein	0.006	0.0574	0.1407
Trichomonas vaginalis	glucosylceramidase, putative	0.0299	0.3251	0.7782
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0027	0.0201	0.4185
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.004	0.0342	0.0922
Mycobacterium tuberculosis	Probable hydrolase	0.004	0.0342	0.0922
Brugia malayi	beta-lactamase	0.004	0.0342	0.0778
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.004	0.0342	0.0922
Brugia malayi	hypothetical protein	0.0042	0.0366	0.0836
Giardia lamblia	Macrophage migration inhibitory factor	0.0373	0.4081	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0299	0.3251	0.7782
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0574	0.1407
Brugia malayi	Cytochrome P450 family protein	0.0038	0.032	0.0725
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.036	0.0823
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0518	0.1271
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0112	0.0275
Mycobacterium ulcerans	hypothetical protein	0.004	0.0342	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0271	0.0665
Echinococcus multilocularis		0.0018	0.0099	0.0094
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0112	0.0107
Plasmodium falciparum	macrophage migration inhibitory factor	0.0373	0.4081	0.5
Onchocerca volvulus		0.004	0.0342	0.026
Echinococcus granulosus	cytochrome P450 2K1	0.0018	0.0099	0.0303
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0271	0.0604
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0518	0.7349
Loa Loa (eye worm)	macrophage migration inhibitory factor	0.0373	0.4081	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0012	0.0028	0.0023
Mycobacterium ulcerans	beta-lactamase	0.004	0.0342	1
Onchocerca volvulus		0.0035	0.0294	0.0084
Mycobacterium tuberculosis	Conserved protein	0.004	0.0342	0.0922
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0035	0.0294	0.0289
Trichomonas vaginalis	glucosylceramidase, putative	0.0207	0.2217	0.5015
Mycobacterium ulcerans	esterase/lipase LipP	0.004	0.0342	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0112	0.0211
Brugia malayi	Cytochrome P450 family protein	0.0027	0.0201	0.043
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0342	0.0126
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0518	0.7349
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0342	0.0838
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0518	0.1213
Brugia malayi	beta-lactamase family protein	0.004	0.0342	0.0778
Brugia malayi	Cytochrome P450 family protein	0.0018	0.0099	0.0179
Trichomonas vaginalis	macrophage migration inhibitory factor, mif, putative	0.0373	0.4081	1
Brugia malayi	hypothetical protein	0.0131	0.1374	0.3323
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1374	0.3366
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.3104	0.31
Mycobacterium tuberculosis	Probable lipase LipE	0.004	0.0342	0.0922
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0518	0.0513
Brugia malayi	Cytochrome P450 family protein	0.0027	0.0201	0.043
Trichomonas vaginalis	conserved hypothetical protein	0.0373	0.4081	1
Loa Loa (eye worm)	CYP4Cod1	0.0027	0.0201	0.0492
Schistosoma mansoni	hypothetical protein	0.0019	0.0112	0.1531
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0112	0.0107
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0299	0.3251	0.7954
Schistosoma mansoni	hypothetical protein	0.0019	0.0112	0.1531
Brugia malayi	hypothetical protein	0.0286	0.3104	0.759
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0064	0.0619	0.0402
Trypanosoma cruzi	cytochrome P450, putative	0.0027	0.0201	0.4185
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0012	0.0028	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0294	0.0721
Brugia malayi	beta-lactamase family protein	0.004	0.0342	0.0778
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0112	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0041	0.036	0.0883
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.004	0.0342	1
Trypanosoma brucei	cytochrome P450, putative	0.0027	0.0201	0.4185
Schistosoma mansoni	cpg binding protein	0.0035	0.0293	0.4114
Brugia malayi	cytochrome P450	0.0018	0.0099	0.0179
Leishmania major	macrophage migration inhibitory factor-like protein	0.0373	0.4081	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0252	0.2732	1
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.0159	0.1683	0.4123
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0342	0.482
Loa Loa (eye worm)	hypothetical protein	0.004	0.0342	0.0838
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0518	0.7349
Schistosoma mansoni	hypothetical protein	0.0019	0.0112	0.1531
Onchocerca volvulus	Huntingtin homolog	0.0131	0.1374	0.4067
Loa Loa (eye worm)	hypothetical protein	0.004	0.0342	0.0838
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0035	0.0294	0.4136
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3104	0.7606
Onchocerca volvulus	Glucosylceramidase homolog	0.0196	0.2098	0.674
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0366	0.036
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0112	0.0345
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0342	1
Loa Loa (eye worm)	histone methyltransferase	0.0012	0.0028	0.0069
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0112	0.0107
Onchocerca volvulus		0.004	0.0342	0.026
Schistosoma mansoni	hypothetical protein	0.0042	0.0366	0.5159
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.2098	0.4698
Mycobacterium tuberculosis	Probable lipase LipD	0.004	0.0342	0.0922
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0518	0.1656
Onchocerca volvulus		0.0058	0.0552	0.1036
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0294	0.4136
Toxoplasma gondii	macrophage migration inhibitory factor, putative	0.0373	0.4081	0.4685
Loa Loa (eye worm)	hypothetical protein	0.004	0.0342	0.0838
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.0272	0.086
Brugia malayi	Bm-MIF-1, identical	0.0373	0.4081	1
Schistosoma mansoni	cpg binding protein	0.0035	0.0293	0.4114
Schistosoma mansoni	cytochrome P450	0.0018	0.0099	0.1346
Loa Loa (eye worm)	cytochrome P450 family protein	0.0038	0.032	0.0785
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0366	0.1163
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0755	0.8376	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.2098	0.4698
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0518	0.1656
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0552	0.7832
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0574	0.1351
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0294	0.4136
Trichomonas vaginalis	glucosylceramidase, putative	0.0299	0.3251	0.7782
Brugia malayi	Pre-SET motif family protein	0.0035	0.0294	0.066
Loa Loa (eye worm)	hypothetical protein	0.004	0.0342	0.0838
Echinococcus granulosus	GPCR family 2	0.0019	0.0112	0.0345
Loa Loa (eye worm)	hypothetical protein	0.004	0.0342	0.0838
Onchocerca volvulus		0.0275	0.2982	1
Leishmania major	macrophage migration inhibitory factor-like protein	0.0373	0.4081	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0518	0.0513
Loa Loa (eye worm)	beta-lactamase	0.004	0.0342	0.0838
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0552	0.1297
Loa Loa (eye worm)	cytochrome P450 family protein	0.0027	0.0201	0.0492
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0294	0.0289
Schistosoma mansoni	hypothetical protein	0.0058	0.0552	0.7832
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0574	0.1351
Mycobacterium tuberculosis	Probable esterase LipL	0.004	0.0342	0.0922
Loa Loa (eye worm)	hypothetical protein	0.004	0.0342	0.0838
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.3104	1
Mycobacterium tuberculosis	Conserved protein	0.004	0.0342	0.0922
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0294	0.4136
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0342	0.482
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1374	0.3366
Mycobacterium leprae	Probable lipase LipE	0.004	0.0342	1
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0342	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0241	0.2609	0.6393
Toxoplasma gondii	ABC1 family protein	0.004	0.0342	0.0059
Trichomonas vaginalis	glucosylceramidase, putative	0.0299	0.3251	0.7782
Trypanosoma cruzi	cytochrome P450, putative	0.0027	0.0201	0.4185
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.0159	0.1683	0.4123
Echinococcus granulosus	cpg binding protein	0.0035	0.0293	0.0927
Onchocerca volvulus		0.004	0.0342	0.026
Mycobacterium tuberculosis	Conserved protein	0.004	0.0342	0.0922
Onchocerca volvulus	Huntingtin homolog	0.0131	0.1374	0.4067
Mycobacterium leprae	conserved hypothetical protein	0.004	0.0342	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0112	0.1531
Loa Loa (eye worm)	cytochrome P450 family protein	0.0027	0.0201	0.0492
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.2098	0.4698
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0342	0.1086
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.004	0.0342	0.0922
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0299	0.3251	0.7968

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.0045 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	20.5878 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	37.933 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	70.7946 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1576017

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1432575