Detailed information for compound 1434476

Basic information

Technical information
  • TDR Targets ID: 1434476
  • Name: 2-(3,5-dimethyl-1H-pyrazol-4-yl)-N-methyletha namine hydrochloride
  • MW: 189.686 | Formula: C8H16ClN3
  • H donors: 2 H acceptors: 1 LogP: 1.65 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNCCc1c(C)n[nH]c1C.Cl
  • InChi: 1S/C8H15N3.ClH/c1-6-8(4-5-9-3)7(2)11-10-6;/h9H,4-5H2,1-3H3,(H,10,11);1H
  • InChiKey: KJUJVTBMGDNUCF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3,5-dimethyl-1H-pyrazol-4-yl)-N-methyl-ethanamine hydrochloride
  • 2-(3,5-dimethyl-1H-pyrazol-4-yl)ethyl-methyl-amine hydrochloride
  • MLS000029484
  • SMR000012681
  • [2-(3,5-Dimethyl-1H-pyrazol-4-yl)-ethyl]-methyl-amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.046 0.0993
Brugia malayi Latrophilin receptor protein 2 0.0013 0.0024 0.0038
Leishmania major trypanothione reductase 0.0089 0.0704 0.1497
Echinococcus granulosus cathepsin l cysteine peptidase 0.0013 0.0023 0.0003
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0031 0.0182 0.0349
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0023 0.0107
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0096 0.0163
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0242 0.0223
Loa Loa (eye worm) hypothetical protein 0.0042 0.0282 0.0604
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0023 0.0107
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0086 0.0139
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0242 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0023 0.0107
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0031 0.0182 0.0162
Echinococcus granulosus dna polymerase kappa 0.002 0.0086 0.0067
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0225 0.193 0.4114
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0036
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0202 0.1727 0.3661
Schistosoma mansoni hypothetical protein 0.0085 0.0671 0.0653
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0182 0.0349
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0167
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0013 0.0023 0.0107
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0242 0.0517
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0013 0.0024 0.0005
Loa Loa (eye worm) hypothetical protein 0.0122 0.1009 0.2197
Brugia malayi nuclear receptor NHR-88 0.0037 0.0242 0.0517
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0042 0.0282 0.0604
Toxoplasma gondii thioredoxin reductase 0.0089 0.0704 0.1497
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0167
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0053 0.0385 0.0828
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0086 0.0124
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0182 0.0349
Leishmania major cathepsin L-like protease 0.005 0.0355 0.073
Echinococcus granulosus dnaJ subfamily B 0.0664 0.5888 0.588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0023 0.0107
Schistosoma mansoni hypothetical protein 0.0664 0.5888 0.588
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0086 0.0402
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0126
Echinococcus granulosus intermediate filament protein 0.0021 0.0095 0.0076
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0242 0.0223
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0385 0.0366
Mycobacterium tuberculosis Probable oxidoreductase 0.0225 0.193 0.4114
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0507 0.4478 0.9799
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0031 0.0182 0.0356
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.046 0.2151
Brugia malayi Pre-SET motif family protein 0.0218 0.1867 0.4078
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0086 0.0174
Echinococcus granulosus cathepsin L cysteine proteinase 0.0013 0.0023 0.0003
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0064 0.0126
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.046 0.0961
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0517 0.4568 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0517 0.4568 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0242 0.0517
Echinococcus granulosus tar DNA binding protein 0.0053 0.0385 0.0366
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0013 0.0024 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0086 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0242 0.0517
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0355 0.0716
Schistosoma mansoni hypothetical protein 0.0029 0.0163 0.0144
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0194 0.0175
Loa Loa (eye worm) hypothetical protein 0.0037 0.0242 0.0517
Schistosoma mansoni hypothetical protein 0.0013 0.0024 0.0005
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0517 0.4568 1
Trypanosoma cruzi trypanothione reductase, putative 0.0089 0.0704 0.1497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0023 0.0107
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0031 0.0182 0.0335
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0167
Brugia malayi hypothetical protein 0.0103 0.0833 0.1811
Trichomonas vaginalis set domain proteins, putative 0.0248 0.2137 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0023 0.0107
Echinococcus multilocularis geminin 0.0142 0.1188 0.1171
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0096 0.016
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0242 0.0223
Plasmodium vivax SET domain protein, putative 0.0032 0.0194 0.0384
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0086 0.0124
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0013 0.0023 0.0003
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0064 0.0126
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0242 0.0517
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0517 0.4568 1
Loa Loa (eye worm) hypothetical protein 0.0199 0.1696 0.3703
Brugia malayi TAR-binding protein 0.0053 0.0385 0.0828
Trypanosoma brucei unspecified product 0.002 0.0086 0.0124
Loa Loa (eye worm) hypothetical protein 0.0037 0.0242 0.0517
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0041 0.027 0.0578
Trichomonas vaginalis glutathione reductase, putative 0.0031 0.0182 0.085
Loa Loa (eye worm) DR-78 0.0018 0.0064 0.0126
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0083 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0023 0.0107
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0242 0.1038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0242 0.0517
Loa Loa (eye worm) ctsf protein 0.0013 0.0023 0.0036
Onchocerca volvulus 0.0018 0.0064 0.0194
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0013 0.0024 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0355 0.0716
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0242 0.0223
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0064 0.0194
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.046 0.0961
Onchocerca volvulus 0.0041 0.027 0.1169
Schistosoma mansoni hypothetical protein 0.0013 0.0024 0.0005
Echinococcus granulosus lamin dm0 0.0021 0.0095 0.0076
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0023 0.0107
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.0043 0.008
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0064 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0086 0.0124
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0086 0.0139
Brugia malayi Cathepsin L-like precursor 0.0013 0.0023 0.0036
Schistosoma mansoni intermediate filament proteins 0.0021 0.0095 0.0076
Onchocerca volvulus 0.0037 0.0242 0.1038
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0507 0.4478 1
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0385 0.0366
Echinococcus multilocularis cysteine protease 0.0013 0.0023 0.0003
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0064 0.0126
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0031 0.0182 0.0162
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0083 0.0167
Onchocerca volvulus 0.0248 0.2137 1
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0064 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0194 0.0175
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0083 0.0064
Schistosoma mansoni lamin 0.0021 0.0095 0.0076
Brugia malayi hypothetical protein 0.0018 0.0064 0.0126
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0031 0.0182 0.0356
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0242 0.0517
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0021 0.0095 0.0194
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0182 0.0349
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0242 0.0223
Brugia malayi conserved hypotetical protein 0.0018 0.0064 0.0126
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0031 0.0182 0.0162
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0023 0.0107
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0064 0.0126
Loa Loa (eye worm) intermediate filament protein 0.0021 0.0095 0.0194
Brugia malayi MAP kinase sur-1 0.0062 0.046 0.0993
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0064 0.0045
Loa Loa (eye worm) hypothetical protein 0.0103 0.0833 0.1811
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0064 0.0045
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.046 0.2151
Echinococcus multilocularis thyroid hormone receptor alpha 0.0037 0.0242 0.0223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0355 0.0716
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0224 0.1925 0.4206
Brugia malayi hypothetical protein 0.002 0.0083 0.0167
Mycobacterium tuberculosis Probable reductase 0.0202 0.1727 0.3661
Trypanosoma brucei PAB1-binding protein , putative 0.0021 0.0096 0.0145
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0031 0.0182 0.0335
Leishmania major hypothetical protein, conserved 0.0021 0.0096 0.016
Schistosoma mansoni zinc finger protein 0.0018 0.0064 0.0045
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0031 0.0182 0.0349
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0242 0.0517
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0023 0.0107
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0175 0.0155
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0013 0.0023 0.0036
Leishmania major DNA polymerase kappa, putative 0.002 0.0086 0.0139
Echinococcus multilocularis dnaJ subfamily B 0.0664 0.5888 0.588
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0086 0.0067
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0086 0.0124
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0086 0.0124
Brugia malayi hypothetical protein 0.0014 0.0028 0.0047
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0064 0.0045
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0042 0.0282 0.0604
Trypanosoma brucei protein kinase, putative 0.0062 0.046 0.0947
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0086 0.0124
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0086 0.0174
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0013 0.0024 0.0005
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0234 0.2015 0.1015
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0182 0.0335
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0126
Brugia malayi hypothetical protein 0.0018 0.0064 0.0126
Loa Loa (eye worm) CXXC zinc finger family protein 0.0047 0.0325 0.0698
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0064 0.0045
Leishmania major cathepsin L-like protease 0.005 0.0355 0.073
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0064 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0086 0.0124
Echinococcus granulosus dna polymerase eta 0.002 0.0086 0.0067
Plasmodium falciparum glutathione reductase 0.0089 0.0704 0.1528
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0126
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0086 0.0139
Brugia malayi nuclear receptor RXR 0.0018 0.0064 0.0126
Brugia malayi ecdysteroid receptor 0.0037 0.0242 0.0517
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0122 0.1009 0.0991
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0031 0.0182 0.0213
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0507 0.4478 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0031 0.0182 0.0356
Echinococcus multilocularis tar DNA binding protein 0.0053 0.0385 0.0366
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0064 0.0045
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0023 0.0003
Brugia malayi nuclear receptor NHR-88 0.0018 0.0064 0.0126
Trypanosoma cruzi GMP reductase 0.0517 0.4568 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0089 0.0711 0.1514
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0202 0.1727 0.3661
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.046 0.0441
Brugia malayi GMP reductase 0.0224 0.1925 0.4206
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0064 0.0045
Plasmodium vivax ataxin-2 like protein, putative 0.0021 0.0096 0.0163
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0064 0.0045
Schistosoma mansoni DNA polymerase eta 0.002 0.0086 0.0067
Leishmania major DNA polymerase eta, putative 0.002 0.0086 0.0139
Loa Loa (eye worm) hypothetical protein 0.002 0.0086 0.0174
Toxoplasma gondii IMP dehydrogenas 0.0517 0.4568 1
Brugia malayi steroid hormone receptor 0.0037 0.0242 0.0517
Echinococcus multilocularis cathepsin L cysteine protease 0.0013 0.0023 0.0003
Onchocerca volvulus 0.0047 0.0325 0.1429
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0182 0.0349
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0086 0.0067
Brugia malayi nuclear receptor NHR-67 0.0018 0.0064 0.0126
Brugia malayi Cathepsin L-like precursor 0.0013 0.0023 0.0036
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0045 0.0026
Echinococcus multilocularis cysteine protease 0.0013 0.0023 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0023 0.0107
Echinococcus multilocularis dna polymerase kappa 0.002 0.0086 0.0067
Brugia malayi Papain family cysteine protease containing protein 0.0013 0.0023 0.0036
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0242 0.0223
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0086 0.0124
Leishmania major inosine-5-monophosphate dehydrogenase 0.0517 0.4568 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0355 0.0716
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0355 0.0716
Onchocerca volvulus 0.0032 0.0194 0.081
Brugia malayi Cathepsin L-like precursor 0.0013 0.0023 0.0036
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0089 0.0704 0.1378
Loa Loa (eye worm) RNA binding protein 0.0053 0.0385 0.0828
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0167
Echinococcus multilocularis lamin dm0 0.0021 0.0095 0.0076
Schistosoma mansoni cpg binding protein 0.0047 0.0325 0.0306
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0242 0.0223
Trypanosoma cruzi major cysteine proteinase, putative 0.0039 0.0259 0.0518
Loa Loa (eye worm) TAR-binding protein 0.0053 0.0385 0.0828
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0242 0.0223
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0023 0.0107
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0064 0.0045
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0064 0.0126
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0242 0.0517
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0023 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0242 0.0517
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0031 0.0182 0.0383
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0013 0.0023 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0023 0.0107
Schistosoma mansoni hypothetical protein 0.0142 0.1188 0.1171
Brugia malayi glutathione reductase 0.0089 0.0704 0.1528
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0242 0.0517
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0064 0.0126
Echinococcus granulosus FTZ F1 alpha 0.0438 0.3851 0.3839
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0083 0.0167
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0083 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0023 0.0107
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0242 0.1038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0355 0.0716
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0126
Loa Loa (eye worm) cysteine protease 0.0013 0.0023 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0242 0.0517
Echinococcus multilocularis cpg binding protein 0.0049 0.0349 0.033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0355 0.0716
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0517 0.4568 0.4557
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0086 0.0124
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0031 0.0182 0.0356
Echinococcus granulosus GPCR family 2 0.0013 0.0024 0.0005
Leishmania major cathepsin L-like protease 0.005 0.0355 0.073
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0064 0.0045
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0108 0.0222
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0013 0.0023 0.0107
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0126
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.0355 0.073
Schistosoma mansoni cpg binding protein 0.0049 0.0349 0.033
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0064 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0023 0.0107
Schistosoma mansoni coup transcription factor 0.0037 0.0242 0.0223
Echinococcus granulosus cpg binding protein 0.0049 0.0349 0.033
Brugia malayi latrophilin 2 splice variant baaae 0.0029 0.0163 0.0342
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0031 0.0182 0.0213
Trichomonas vaginalis mercuric reductase, putative 0.0031 0.0182 0.085
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0242 0.0223
Loa Loa (eye worm) latrophilin receptor protein 2 0.0013 0.0024 0.0038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0242 0.0223
Loa Loa (eye worm) histone methyltransferase 0.0016 0.0045 0.0084
Brugia malayi Thioredoxin reductase 0.0089 0.0704 0.1528
Schistosoma mansoni microtubule-associated protein tau 0.112 1 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0089 0.0708 0.069
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0242 0.0517
Schistosoma mansoni nuclear receptor 0.0018 0.0064 0.0045
Echinococcus multilocularis microtubule associated protein 2 0.112 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0086 0.0124
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0195
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0517 0.4568 1
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0234 0.2015 0.4304
Echinococcus multilocularis survival motor neuron protein 1 0.0199 0.1696 0.168
Echinococcus multilocularis GPCR, family 2 0.0013 0.0024 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.046 0.2151
Echinococcus granulosus cathepsin l1 0.0013 0.0023 0.0003
Loa Loa (eye worm) fibroinase 0.0013 0.0023 0.0036
Loa Loa (eye worm) hypothetical protein 0.0118 0.0971 0.2114
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.046 0.0441
Onchocerca volvulus Putative GMP reductase 0.0224 0.1925 0.9
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0126
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0182 0.0349
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0242 0.0223
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0064 0.0045
Brugia malayi RNA binding protein 0.0053 0.0385 0.0828
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0355 0.0716
Toxoplasma gondii LsmAD domain-containing protein 0.0021 0.0096 0.016
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0242 0.0223
Loa Loa (eye worm) hypothetical protein 0.0037 0.0242 0.0517
Brugia malayi ecdysone receptor 0.0018 0.0064 0.0126
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0242 0.0517
Loa Loa (eye worm) hypothetical protein 0.0037 0.0242 0.0517
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0182 0.0349
Brugia malayi Cathepsin L-like precursor 0.0013 0.0023 0.0036
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0086 0.0139
Schistosoma mansoni hypothetical protein 0.0041 0.027 0.0251
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0242 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0086 0.0124
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.046 0.0441
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0023 0.0107
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.046 0.2151
Schistosoma mansoni mixed-lineage leukemia protein mll 0.01 0.0806 0.0788
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0242 0.0517
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0182 0.0349
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0122 0.1009 0.2197
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.046 0.0441
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.1867 0.4078
Onchocerca volvulus Huntingtin homolog 0.0103 0.0833 0.3831
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0224 0.1925 0.4206
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0182 0.0335
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0242 0.0517
Brugia malayi hypothetical protein 0.0199 0.1696 0.3703
Loa Loa (eye worm) GMP reductase 0.0224 0.1925 0.4206
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0242 0.0223
Plasmodium vivax thioredoxin reductase, putative 0.0089 0.0704 0.1528
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0242 0.0223
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0283 0.2458 0.2572
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0186
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0031 0.0182 0.0213
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0013 0.0024 0.0038
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0182 0.0349
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0086 0.0402
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0242 0.0517
Echinococcus multilocularis musashi 0.0021 0.0095 0.0076
Onchocerca volvulus 0.0118 0.0971 0.4484
Treponema pallidum NADH oxidase 0.0031 0.0182 0.5
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0086 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0023 0.0107
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0194 0.0175
Trypanosoma brucei trypanothione reductase 0.0089 0.0704 0.1485
Plasmodium falciparum glutathione reductase 0.0031 0.0182 0.0356
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0086 0.0139
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.046 0.0441
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0086 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0242 0.0223
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0064 0.0126
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0385 0.0366
Brugia malayi tailless protein 0.0018 0.0064 0.0126
Brugia malayi Intermediate filament tail domain containing protein 0.0021 0.0095 0.0194
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0385 0.0366
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0064 0.0126
Schistosoma mansoni cpg binding protein 0.0049 0.0349 0.033
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0283 0.2458 0.5291
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.046 0.0961
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0167
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0086 0.0124
Schistosoma mansoni hypothetical protein 0.0013 0.0024 0.0005
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0242 0.0517
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0083 0.0167
Echinococcus granulosus survival motor neuron protein 1 0.0199 0.1696 0.168
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.046 0.0961
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0126
Loa Loa (eye worm) glutathione reductase 0.0089 0.0704 0.1528
Schistosoma mansoni hypothetical protein 0.0013 0.0024 0.0005
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0023 0.0003
Brugia malayi nuclear receptor RXR 0.002 0.0083 0.0167
Echinococcus multilocularis lamin 0.0021 0.0095 0.0076
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0083 0.0064
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0517 0.4568 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0038
Echinococcus multilocularis FTZ F1 alpha 0.0122 0.1009 0.0991
Brugia malayi hypothetical protein 0.0021 0.0096 0.0195
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0194 0.0175
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0355 0.0716
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0182 0.0349
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0194 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0242 0.0517
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0045 0.0026
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0517 0.4568 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0242 0.0517
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0031 0.0182 0.0213
Onchocerca volvulus Huntingtin homolog 0.0103 0.0833 0.3831
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0126
Plasmodium falciparum thioredoxin reductase 0.0089 0.0704 0.1528
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0242 0.0223
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0064 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0023 0.0107
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0202 0.1727 0.3661
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.0355 0.073
Loa Loa (eye worm) IMP dehydrogenase 1 0.0517 0.4568 1
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0064 0.0045
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.046 0.0961
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0194
Brugia malayi hypothetical protein 0.002 0.0083 0.0167
Brugia malayi intermediate filament protein 0.0021 0.0095 0.0194
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0108 0.0222
Schistosoma mansoni survival motor neuron protein 0.0041 0.027 0.0251
Schistosoma mansoni hypothetical protein 0.0142 0.1188 0.1171
Brugia malayi Pre-SET motif family protein 0.0032 0.0194 0.0411
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0086 0.0124
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0064 0.0045
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0242 0.0223
Plasmodium falciparum thioredoxin reductase 0.0031 0.0182 0.0356
Loa Loa (eye worm) hypothetical protein 0.0037 0.0242 0.0517
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0086 0.0067
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0242 0.1038
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0517 0.4568 1
Brugia malayi nuclear hormone receptor 0.0037 0.0242 0.0517
Brugia malayi RNA recognition motif domain containing protein 0.0053 0.0385 0.0828
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0096 0.016
Echinococcus multilocularis dna polymerase eta 0.002 0.0086 0.0067
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0194 0.0377
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0517 0.4568 0.4557
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0355 0.0716
Giardia lamblia NADH oxidase lateral transfer candidate 0.0031 0.0182 0.2561
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0122 0.1009 0.0991
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0064 0.0126
Brugia malayi CXXC zinc finger family protein 0.0047 0.0325 0.0698
Echinococcus granulosus geminin 0.0142 0.1188 0.1171
Trypanosoma cruzi cruzipain precursor, putative 0.005 0.0355 0.073
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0517 0.4568 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0242 0.0223
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0194 0.0175
Onchocerca volvulus 0.0021 0.0095 0.0341
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0225 0.193 0.0716
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0225 0.193 0.4114
Brugia malayi nuclear hormone receptor 0.0018 0.0064 0.0126
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0182 0.0349
Echinococcus multilocularis cathepsin L cysteine protease 0.0013 0.0023 0.0003
Trypanosoma cruzi GMP reductase 0.0517 0.4568 1
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.046 1
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0242 0.0223
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0122 0.1009 0.0991
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0086 0.0124
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0031 0.0182 0.0349
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0194 0.0175
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0023 0.0107
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0202 0.1727 0.3661
Echinococcus multilocularis thioredoxin glutathione reductase 0.0089 0.0708 0.069
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.046 0.0947
Brugia malayi Cathepsin L-like precursor 0.0013 0.0023 0.0036
Loa Loa (eye worm) hypothetical protein 0.0037 0.0242 0.0517
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0385 0.0366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0023 0.0107
Brugia malayi Calcitonin receptor-like protein seb-1 0.0042 0.0282 0.0604
Trypanosoma cruzi trypanothione reductase, putative 0.0031 0.0182 0.0349
Schistosoma mansoni lamin 0.0021 0.0095 0.0076
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0122 0.1009 0.2197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0355 0.0716
Leishmania major guanosine monophosphate reductase 0.0517 0.4568 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0046 0.0316 0.0644
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0242 0.0517
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0013 0.0023 0.0003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0242 0.0223
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0086 0.0174
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0064 0.0045
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.046 0.0961
Brugia malayi hypothetical protein 0.0118 0.0971 0.2114
Loa Loa (eye worm) hypothetical protein 0.0032 0.0194 0.0411
Loa Loa (eye worm) hypothetical protein 0.0037 0.0242 0.0517
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0031 0.0182 0.5
Echinococcus granulosus lamin 0.0021 0.0095 0.0076
Loa Loa (eye worm) hypothetical protein 0.0029 0.0163 0.0342
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.0355 0.073
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.046 0.0961
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0023 0.0107
Schistosoma mansoni nuclear receptor 0.0018 0.0064 0.0045
Loa Loa (eye worm) hypothetical protein 0.0103 0.0833 0.1811
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0023 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0242 0.0517
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0096 0.0163
Onchocerca volvulus 0.0018 0.0064 0.0194
Toxoplasma gondii NADPH-glutathione reductase 0.0031 0.0182 0.0349
Mycobacterium tuberculosis Probable dehydrogenase 0.0202 0.1727 0.3661
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0242 0.0223
Plasmodium vivax glutathione reductase, putative 0.0089 0.0704 0.1528
Trypanosoma brucei GMP reductase 0.0517 0.4568 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0242 0.0223
Brugia malayi Cathepsin L-like precursor 0.0013 0.0023 0.0036
Onchocerca volvulus 0.0021 0.0095 0.0341
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0517 0.4568 0.4557
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0242 0.0517
Loa Loa (eye worm) thioredoxin reductase 0.0089 0.0704 0.1528

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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