TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 385.929 | Formula: C19H32ClN3O3
H donors: 1 H acceptors: 1 LogP: 3.35 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCCN1CCN(CC1)CC(=O)Nc1cc(OCC)ccc1OCC.Cl
InChi: 1S/C19H31N3O3.ClH/c1-4-9-21-10-12-22(13-11-21)15-19(23)20-17-14-16(24-5-2)7-8-18(17)25-6-3;/h7-8,14H,4-6,9-13,15H2,1-3H3,(H,20,23);1H
InChiKey: VPQFLTOLTYHKMZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lysine (K)-specific demethylase 4A	Starlite/ChEMBL	No references
Homo sapiens	chromobox homolog 1	Starlite/ChEMBL	No references
Homo sapiens	K(lysine) acetyltransferase 2A	Starlite/ChEMBL	No references
Giardia intestinalis	Putative fructose-1,6-bisphosphate aldolase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	hypothetical protein	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	Get druggable targets OG5_127781	All targets in OG5_127781
Entamoeba histolytica	acetyltransferase, GNAT family	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Echinococcus granulosus	Transcription factor JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Plasmodium falciparum	histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Onchocerca volvulus		Get druggable targets OG5_129545	All targets in OG5_129545
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Brugia malayi	jmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Cryptosporidium hominis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	JmjC domain-containing histone demethylation protein 3C, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Neospora caninum	Bromodomain containing protein, related	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	jmjC domain-containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Giardia lamblia	Histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Giardia lamblia	Fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Plasmodium vivax	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium yoelii	histone acetyltransferase GCN5-related	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Loa Loa (eye worm)	heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma japonicum	Probable JmjC domain-containing histone demethylation protein 3B, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Plasmodium berghei	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Plasmodium knowlesi	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Treponema pallidum	fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Schistosoma japonicum	Chromobox protein homolog 5, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Theileria parva	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Onchocerca volvulus	Heterochromatin protein 1 homolog	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Schistosoma mansoni	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Brugia malayi	acetyltransferase, GNAT family protein	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	ko:K06062 p300/CBP-associated factor, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Babesia bovis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Brugia malayi	Heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Cryptosporidium parvum	GCN5 like acetylase + bromodomain	Get druggable targets OG5_127781	All targets in OG5_127781
Theileria parva	histone acetyltransferase Gcn5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.8 %
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %
Mycobacterium ulcerans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	26.9 %
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1797	1	1
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0172	0.0716	1
Loa Loa (eye worm)	hypothetical protein	0.0267	0.1256	0.2344
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.017	0.0703	0.0693
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.1747	0.3965
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0175	0.073	0.0721
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0546	0.285	0.6497
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0595	0.3131	0.7142
Echinococcus granulosus	chromobox protein 1	0.0084	0.0211	0.0201
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0625	0.3303	0.7537
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0315	0.1528	0.152
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.017	0.0703	0.0666
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.0211	0.0438
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.017	0.0703	0.0314
Echinococcus multilocularis	chromobox protein 1	0.0084	0.0211	0.0201
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0813	0.4375	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0595	0.3131	0.7142
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0051	0.0025	0.001
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0231	0.1052	0.1043
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.017	0.0703	0.1869
Giardia lamblia	Fructose-bisphosphate aldolase	0.0353	0.1747	0.4645
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0349	0.1724	0.5019
Trichomonas vaginalis	conserved hypothetical protein	0.0231	0.1052	0.2369
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0118	0.0402	0.1115
Brugia malayi	acetyltransferase, GNAT family protein	0.0175	0.073	0.0693
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0706	0.3762	0.3627
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0398	0.2004	0.4032
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0118	0.0402	0.5565
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0118	0.0402	0.1115
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0315	0.1528	0.2835
Entamoeba histolytica	protein kinase rad3, putative	0.0315	0.1528	0.4063
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0118	0.0402	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0315	0.1528	0.2857
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0118	0.0402	0.1069
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0461	0.2363	0.2333
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0118	0.0402	0.0392
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.1747	0.3965
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0118	0.0402	0.0364
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0644	0.341	0.7784
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0706	0.3762	0.8455
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0118	0.0402	0.0876
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.016	0.0642	0.025
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0644	0.341	0.7784
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.1086	0.5936	0.5931
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.017	0.0703	0.0502
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0118	0.0402	0.0876
Echinococcus multilocularis		0.0118	0.0402	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0441	0.225	0.4214
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0595	0.3129	0.7139
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0425	0.2159	0.4912
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0582	0.3054	0.8118
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0118	0.0402	0.0738
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0881	0.4766	0.4761
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0813	0.4375	1
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.017	0.0703	0.0693
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0315	0.1528	0.1346
Schistosoma mansoni	jumonji domain containing protein	0.0092	0.0254	0.0044
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0277	0.1313	0.1126
Echinococcus multilocularis	Zinc finger, PHD finger	0.017	0.0703	0.0693
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0118	0.0402	0.0392
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0315	0.1528	0.1173
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.017	0.0703	0.0757
Entamoeba histolytica	hypothetical protein	0.0518	0.2692	0.7157
Loa Loa (eye worm)	phosphatidylinositol 3	0.0979	0.5325	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0546	0.285	0.6161
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0118	0.0402	0.0195
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.1747	0.3965
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0118	0.0402	0.0392
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0657	0.3482	0.7752
Loa Loa (eye worm)	phosphatidylinositol 3	0.0118	0.0402	0.0738
Trypanosoma cruzi	target of rapamycin kinase 3	0.0657	0.3482	0.3209
Plasmodium vivax	hypothetical protein, conserved	0.0118	0.0402	0.5565
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0413	0.2089	0.4749
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0706	0.3762	0.3755
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.1747	0.3965
Brugia malayi	jmjC domain containing protein	0.0115	0.0389	0.0351
Loa Loa (eye worm)	phosphatidylinositol 3	0.0118	0.0402	0.0738
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0118	0.0402	0.0392
Giardia lamblia	Hypothetical protein	0.0118	0.0402	0.1069
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0706	0.3762	0.3755
Loa Loa (eye worm)	hypothetical protein	0.0231	0.1052	0.196
Loa Loa (eye worm)	phosphatidylinositol 3	0.0813	0.4375	0.8213
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.017	0.0703	0.0757
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0625	0.3303	0.3276
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0231	0.1052	0.1043
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0355	0.1756	0.4669
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.017	0.0703	0.1567
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0706	0.3762	0.8455
Loa Loa (eye worm)	phosphatidylinositol 3	0.0118	0.0402	0.0738
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0172	0.0716	0.5
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0197	0.0857	0.0474
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0118	0.0402	0.0392
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0706	0.3762	0.8455
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0656	0.3481	0.7946
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.017	0.0703	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0657	0.3482	0.7752
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0118	0.0402	0.1069
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0644	0.341	0.7784
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0706	0.3762	0.8591
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0813	0.4375	1
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0546	0.285	0.6161
Echinococcus multilocularis	chromobox protein 1	0.0084	0.0211	0.0201
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0115	0.0389	0.0379
Toxoplasma gondii	FATC domain-containing protein	0.0315	0.1528	0.4442
Brugia malayi	Cytochrome P450 family protein	0.0059	0.0066	0.0026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0118	0.0402	0.0876
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0315	0.1528	0.152
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0474	0.244	0.5556
Entamoeba histolytica	hypothetical protein	0.0118	0.0402	0.1069
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.1747	0.3965
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.017	0.0703	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0459	0.2355	0.536
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0277	0.1313	0.2969
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0277	0.1313	0.2969
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0706	0.3762	1
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0625	0.3303	0.7537
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0118	0.0402	0.5565
Brugia malayi	Heterochromatin protein 1	0.0084	0.0211	0.0172
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0607	0.3201	0.7304
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0656	0.3481	0.7946
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0595	0.3129	0.7139
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1797	1	1
Schistosoma mansoni	hypothetical protein	0.0118	0.0402	0.0195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0546	0.285	0.6497
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.004	0.0057
Echinococcus granulosus	serine protein kinase ATM	0.0315	0.1528	0.152
Loa Loa (eye worm)	hypothetical protein	0.0054	0.004	0.0057
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.017	0.0703	0.2004
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0118	0.0402	0.1115
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0277	0.1313	0.2969
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.1747	0.4645
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0625	0.3303	0.878
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0625	0.3303	0.3022
Loa Loa (eye worm)	cytochrome P450 family protein	0.0059	0.0066	0.0105
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0166	0.0682	0.1518
Entamoeba histolytica	hypothetical protein	0.0315	0.1528	0.4063
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0197	0.0857	0.192
Loa Loa (eye worm)	phosphatidylinositol 3	0.0118	0.0402	0.0738
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0625	0.3303	0.3022
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0441	0.225	0.2218
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0582	0.3054	0.6965
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1797	1	1
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0706	0.3762	0.8455
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0461	0.2367	0.5388
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.017	0.0703	0.1567
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.0146	0.0256
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0216	0.0962	0.141
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0706	0.3762	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0051	0.0025	0.001
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0115	0.0389	0.0379
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0706	0.3762	0.35
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0402	0.0738
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0315	0.1528	0.1494
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0413	0.2089	0.4749
Entamoeba histolytica	hypothetical protein	0.0118	0.0402	0.1069
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0334	0.1639	0.4357
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0644	0.341	1
Echinococcus multilocularis	serine protein kinase ATM	0.0315	0.1528	0.152
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0277	0.1313	0.3492
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0413	0.2089	0.4749
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0118	0.0402	0.0392
Loa Loa (eye worm)	hypothetical protein	0.006	0.0075	0.0123
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0118	0.0402	0.0392
Loa Loa (eye worm)	phosphatidylinositol 3	0.0706	0.3762	0.7058
Onchocerca volvulus		0.0118	0.0402	1
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0441	0.225	0.2242
Loa Loa (eye worm)	phosphatidylinositol 3	0.016	0.0642	0.1189
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0706	0.3762	0.35
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0315	0.1528	0.1173
Treponema pallidum	fructose-bisphosphate aldolase	0.0353	0.1747	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0656	0.3481	0.7946
Loa Loa (eye worm)	hypothetical protein	0.0197	0.0857	0.1593
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.1747	0.3965
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.017	0.0703	0.0502
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0118	0.0402	0.0195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0644	0.341	0.7784
Echinococcus granulosus	chromobox protein 1	0.0084	0.0211	0.0201
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0315	0.1528	0.1494
Trichomonas vaginalis	conserved hypothetical protein	0.0349	0.1724	0.3911
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0277	0.1313	0.1279
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0644	0.341	0.7784
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.017	0.0703	0.1869
Entamoeba histolytica	hypothetical protein	0.0118	0.0402	0.1069
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.0211	0.0438
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0118	0.0402	0.0876
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0315	0.1528	0.1346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0315	0.1528	0.3463
Leishmania major	phosphatidylinositol 3-kinase, putative	0.017	0.0703	0.0757
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0625	0.3303	0.7537
Trichomonas vaginalis	conserved hypothetical protein	0.0197	0.0857	0.192
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.017	0.0703	0.0314
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0706	0.3762	0.8591
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0706	0.3762	0.8591
Loa Loa (eye worm)	hypothetical protein	0.0184	0.0784	0.1455
Echinococcus granulosus	histone acetyltransferase KAT2B	0.017	0.0702	0.0693
Loa Loa (eye worm)	heterochromatin protein 1	0.0084	0.0211	0.0379
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0118	0.0402	0.5719
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.1086	0.5936	0.5931
Schistosoma mansoni	hypothetical protein	0.0231	0.1052	0.0859
Brugia malayi	FAT domain containing protein	0.0231	0.1052	0.1016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0595	0.3129	0.7139
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0118	0.0402	0.0364
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0277	0.1313	0.095
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0175	0.073	0.0531
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0644	0.341	0.7784
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0706	0.3762	0.3737
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.1747	0.4645
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0595	0.3131	0.7142
Onchocerca volvulus		0.0118	0.0402	1
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0441	0.225	0.2242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0644	0.341	0.7784
Giardia lamblia	GTOR	0.0706	0.3762	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.1747	0.3965
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1797	1	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.017	0.0703	0.2004
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0277	0.1313	0.3492
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0224	0.1013	0.2692
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.017	0.0703	0.1567
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0461	0.2367	0.5388
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.017	0.0703	0.0693
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0518	0.2692	0.7157
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0595	0.3131	0.7142
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0118	0.0402	0.5565
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0315	0.1528	0.3463
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0546	0.285	0.6497
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0656	0.3481	0.7946
Loa Loa (eye worm)	hypothetical protein	0.0349	0.1724	0.3224
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.0025	0.0014
Plasmodium vivax	hypothetical protein	0.0118	0.0402	0.5565
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.017	0.0703	0.1304
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0172	0.0716	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.1747	0.3965
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0118	0.0402	0.0195
Loa Loa (eye worm)	acetyltransferase	0.0175	0.073	0.1356
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0546	0.285	0.6497
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0118	0.0402	0.5719
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0656	0.3481	0.7946
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1797	1	1
Loa Loa (eye worm)	hypothetical protein	0.0267	0.1256	0.2344
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0508	0.2631	0.6995
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.1086	0.5936	0.5848
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0607	0.3201	0.7304
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0277	0.1313	0.2294

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	8.9125 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398]	ChEMBL.	No reference
Potency (functional)	10 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	= 17.7828 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1599600

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1436697