Detailed information for compound 1437436

Basic information

Technical information
  • TDR Targets ID: 1437436
  • Name: N-[2-[[2-(cyclopentylamino)-2-oxo-1-pyridin-3 -ylethyl]-(2-ethoxyphenyl)amino]-2-oxoethyl]f uran-2-carboxamide
  • MW: 490.551 | Formula: C27H30N4O5
  • H donors: 2 H acceptors: 4 LogP: 3.26 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1N(C(c1cccnc1)C(=O)NC1CCCC1)C(=O)CNC(=O)c1ccco1
  • InChi: 1S/C27H30N4O5/c1-2-35-22-13-6-5-12-21(22)31(24(32)18-29-26(33)23-14-8-16-36-23)25(19-9-7-15-28-17-19)27(34)30-20-10-3-4-11-20/h5-9,12-17,20,25H,2-4,10-11,18H2,1H3,(H,29,33)(H,30,34)
  • InChiKey: PXGYEKSNRORNSW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[[2-(cyclopentylamino)-2-oxo-1-(3-pyridyl)ethyl]-(2-ethoxyphenyl)amino]-2-oxo-ethyl]furan-2-carboxamide
  • N-[2-[[2-(cyclopentylamino)-2-oxo-1-(3-pyridyl)ethyl]-(2-ethoxyphenyl)amino]-2-oxoethyl]-2-furancarboxamide
  • N-[2-[[2-(cyclopentylamino)-2-keto-1-(3-pyridyl)ethyl]-(2-ethoxyphenyl)amino]-2-keto-ethyl]-2-furamide
  • N-[2-[[2-(cyclopentylamino)-2-oxo-1-pyridin-3-yl-ethyl]-(2-ethoxyphenyl)amino]-2-oxo-ethyl]furan-2-carboxamide
  • Furan-2-carboxylic acid {[(cyclopentylcarbamoyl-pyridin-3-yl-methyl)-(2-ethoxy-phenyl)-carbamoyl]-methyl}-amide
  • ASN 05584595
  • SMR000005178
  • MLS000880799
  • MLS000032298

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum importin beta, putative 0.0035 0.0034 0.0365
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0046 0.051
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0013 0.0159
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.5474 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0022 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0159
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0472 0.0835 1
Brugia malayi MBOAT family protein 0.0472 0.0835 0.0831
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0004 0.0048
Schistosoma mansoni zinc finger protein 0.5474 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0022 0.022
Brugia malayi diacylglycerol acyltransferase 0.0472 0.0835 0.0831
Leishmania major cytochrome p450-like protein 0.0022 0.0011 0.0088
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0006 0.0019
Entamoeba histolytica hypothetical protein 0.0472 0.0835 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.007 0.0789
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0006 0.0002
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0036 0.0389
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.004 0.0434
Schistosoma mansoni lipoxygenase 0.008 0.0117 0.0113
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0002
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0472 0.0835 0.0831
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0013 0.0009
Brugia malayi Muscleblind-like protein 0.0145 0.0236 0.0232
Schistosoma mansoni hypothetical protein 0.0472 0.0835 0.0831
Echinococcus granulosus zinc finger protein 0.5002 0.9136 0.9135
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0472 0.0835 0.0831
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0472 0.0835 0.0831
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.5474 1 1
Brugia malayi MBOAT family protein 0.0472 0.0835 0.0831
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0236 0.0232
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0472 0.0835 0.0831
Trichomonas vaginalis conserved hypothetical protein 0.0472 0.0835 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0018 0.021
Loa Loa (eye worm) hypothetical protein 0.0145 0.0236 0.0232
Echinococcus granulosus importin subunit beta 1 0.0035 0.0034 0.003
Loa Loa (eye worm) MBOAT family protein 0.0472 0.0835 0.0831
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0472 0.0835 0.0831
Echinococcus granulosus neuropeptide s receptor 0.0448 0.0791 0.0787
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.0145 0.0236 0.0232
Entamoeba histolytica hypothetical protein 0.0035 0.0035 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0472 0.0835 1
Entamoeba histolytica hypothetical protein, conserved 0.0472 0.0835 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0006 0.0002
Entamoeba histolytica hypothetical protein 0.0028 0.0022 0.022
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0006 0.0002
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0472 0.0835 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0472 0.0835 0.0831
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0036 0.0389
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0159
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0013 0.0159
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0013 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0006 0.0002
Brugia malayi hypothetical protein 0.0019 0.0006 0.0002
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0229 0.0225
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0013 0.0009
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0472 0.0835 0.0831
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0472 0.0835 0.0831
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0013 0.0009
Plasmodium vivax importin-beta 2, putative 0.0035 0.0034 0.0365
Leishmania major importin beta-1 subunit, putative 0.0028 0.0022 0.022
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0013 0.0111
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0018 0.0013
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.004 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0018 0.0162
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0036 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0159
Echinococcus granulosus dna polymerase kappa 0.0023 0.0013 0.0009
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0018 0.0162
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0036 0.0032
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0034 0.0412
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0002
Schistosoma mansoni rab6-interacting 0.0019 0.0006 0.0002
Echinococcus multilocularis zinc finger protein 0.5002 0.9136 0.9135
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0036 0.8968
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0036 0.0389
Leishmania major glycerol uptake protein, putative 0.0472 0.0835 1
Loa Loa (eye worm) hypothetical protein 0.0472 0.0835 0.0831
Leishmania major glycerol uptake protein, putative 0.0472 0.0835 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0013 0.0111
Leishmania major glycerol uptake protein, putative 0.0472 0.0835 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.004 0.0435
Schistosoma mansoni ran 0.0026 0.0018 0.0013
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0472 0.0835 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0013 0.0111
Trypanosoma brucei glycerol uptake protein, putative 0.0472 0.0835 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0035 0.0031
Trichomonas vaginalis transmembrane protein nessy, putative 0.0472 0.0835 1
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0472 0.0835 0.0831
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0472 0.0835 0.0831
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0472 0.0835 0.0831
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0011 0.0136
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0013 0.0111
Toxoplasma gondii hypothetical protein 0.0472 0.0835 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0036 0.0389
Trypanosoma cruzi glycerol uptake protein, putative 0.0472 0.0835 1
Trichomonas vaginalis porcupine, putative 0.0472 0.0835 1
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0472 0.0835 0.0831
Brugia malayi Cytochrome P450 family protein 0.0022 0.0011 0.0007
Trypanosoma cruzi GUP1, putative 0.0472 0.0835 1
Schistosoma mansoni hypothetical protein 0.0035 0.0035 0.0031
Loa Loa (eye worm) MBOAT family protein 0.5474 1 1
Echinococcus multilocularis sterol O acyltransferase 1 0.0472 0.0835 0.0831
Echinococcus granulosus snurportin 1 0.0372 0.0652 0.0648
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0018 0.0162
Schistosoma mansoni sterol O-acyltransferase 1 0.0472 0.0835 0.0831
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0046 0.0042
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0011 0.793
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0046 0.051
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0011 0.0007
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0472 0.0835 0.0831
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0159
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0013 0.0009
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.018 0.0177
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0472 0.0835 0.0831
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0159
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0011 0.0007
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0036 0.0032
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0006 0.0002
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.004 0.0435
Loa Loa (eye worm) hypothetical protein 0.0035 0.0034 0.003
Brugia malayi Cytochrome P450 family protein 0.0022 0.0011 0.0007
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0472 0.0835 0.0831
Loa Loa (eye worm) hhat protein 0.0472 0.0835 0.0831
Brugia malayi Doublecortin family protein 0.0019 0.0006 0.0002
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0006 0.0002
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0472 0.0835 0.0831
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.004 0.0434
Echinococcus granulosus dna polymerase eta 0.0054 0.007 0.0066
Loa Loa (eye worm) hhat protein 0.0472 0.0835 0.0831
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0018 0.0013
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0004 0.5
Loa Loa (eye worm) hypothetical protein 0.0472 0.0835 0.0831
Entamoeba histolytica hypothetical protein 0.0035 0.0035 0.0378
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0018 0.0162
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0013 0.0009
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0472 0.0835 1
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0013 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.007 0.0066
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0046 0.051
Trypanosoma cruzi glycerol uptake protein, putative 0.0472 0.0835 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0036 0.0032
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0472 0.0835 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0472 0.0835 0.0831
Schistosoma mansoni ran 0.0026 0.0018 0.0013
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0035 0.0031
Echinococcus multilocularis muscleblind protein 0.0145 0.0236 0.0232
Trypanosoma cruzi GUP1, putative 0.0472 0.0835 1
Schistosoma mansoni rab6-interacting 0.0019 0.0006 0.0002
Leishmania major DNA polymerase eta, putative 0.0054 0.007 0.0789
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0159
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0036 0.0032
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0013 0.0111
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0036 0.0032
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0036 0.0032
Trypanosoma brucei glycerol uptake protein, putative 0.0472 0.0835 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0036 0.0389
Echinococcus granulosus o acyltransferase membrane bound domain 0.0472 0.0835 0.0831
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0472 0.0835 0.0831
Leishmania major DNA polymerase kappa, putative 0.0023 0.0013 0.0111
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0022 0.022
Loa Loa (eye worm) acetyltransferase 0.0141 0.0229 0.0225
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0034 0.0365
Echinococcus multilocularis neuropeptide s receptor 0.0448 0.0791 0.0787
Schistosoma mansoni DNA polymerase eta 0.0054 0.007 0.0066
Leishmania major glycerol uptake protein, putative 0.0472 0.0835 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0018 0.0013
Brugia malayi hypothetical protein 0.0035 0.0035 0.0031
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0011 0.0088
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0011 0.0007
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0013 0.0009
Brugia malayi RNA, U transporter 1 0.0099 0.0152 0.0148
Onchocerca volvulus 0.0472 0.0835 1
Brugia malayi MBOAT family protein 0.0472 0.0835 0.0831
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0159
Schistosoma mansoni polycystin 1-related 0.0019 0.0006 0.0002
Schistosoma mansoni lipoxygenase 0.0115 0.018 0.0177
Echinococcus multilocularis RUN 0.0019 0.0006 0.0002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0013 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0472 0.0835 1
Loa Loa (eye worm) hypothetical protein 0.0472 0.0835 0.0831
Echinococcus granulosus sterol O acyltransferase 1 0.0472 0.0835 0.0831
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0159
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0036 0.0032
Echinococcus multilocularis dna polymerase eta 0.0054 0.007 0.0066
Schistosoma mansoni importin beta-1 0.0035 0.0034 0.003
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0006 0.0002
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0472 0.0835 0.0831
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0013 0.0111
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0011 0.0088
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0652 0.0648
Echinococcus multilocularis snurportin 1 0.0372 0.0652 0.0648
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0046 0.051
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0229 0.0225
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0472 0.0835 1
Leishmania major GTP-binding protein, putative 0.0026 0.0018 0.0162
Brugia malayi Hhat protein 0.0472 0.0835 0.0831
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0032
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0018 0.0013
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0013 0.0111
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0006 0.0019
Schistosoma mansoni hypothetical protein 0.0019 0.0006 0.0002
Leishmania major DNA polymerase eta, putative 0.0038 0.004 0.0435
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0034 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0036 0.0389
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0472 0.0835 1
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.007 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0159
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0013 0.0159
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0046 0.051
Echinococcus multilocularis neuropeptide receptor A26 0.0448 0.0791 0.0787
Treponema pallidum alginate O-acetylation protein (algI) 0.0472 0.0835 1
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0022 0.022
Brugia malayi Importin beta-1 subunit 0.0035 0.0034 0.003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0013 0.0111
Leishmania major hypothetical protein, conserved 0.0472 0.0835 1
Schistosoma mansoni hypothetical protein 0.0372 0.0652 0.0648
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0036 0.0436
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0472 0.0835 0.0831
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0034 0.0412
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.007 0.0834
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0035 0.0031
Echinococcus granulosus RUN 0.0019 0.0006 0.0002
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0018 0.3737
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0013 1
Giardia lamblia DINP protein human, muc B family 0.0023 0.0013 0.2558
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0064 0.006
Entamoeba histolytica hypothetical protein 0.0035 0.0035 0.0378
Leishmania major glycerol uptake protein, putative 0.0472 0.0835 1
Entamoeba histolytica Ran family GTPase 0.0026 0.0018 0.0162
Trichomonas vaginalis ran, putative 0.0026 0.0018 0.0162
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0159
Entamoeba histolytica hypothetical protein 0.0035 0.0035 0.0378
Loa Loa (eye worm) hypothetical protein 0.0472 0.0835 0.0831
Brugia malayi hypothetical protein 0.0019 0.0006 0.0002
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.018 0.0177
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0036 0.0389
Brugia malayi MBOAT family protein 0.0472 0.0835 0.0831
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0221 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0472 0.0835 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0013 0.0009
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0472 0.0835 0.0831
Brugia malayi Cytochrome P450 family protein 0.0051 0.0064 0.006
Loa Loa (eye worm) MBOAT family protein 0.0472 0.0835 0.0831
Echinococcus granulosus muscleblind protein 0.0145 0.0236 0.0232
Schistosoma mansoni loxhd1 0.0019 0.0006 0.0002
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0229 0.0225
Entamoeba histolytica vacuolar protein sorting 26 0.0472 0.0835 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0018 0.0162
Trypanosoma brucei unspecified product 0.0023 0.0013 0.0159
Echinococcus granulosus neuropeptide receptor A26 0.0448 0.0791 0.0787

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0058 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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