TDR Targets

Basic information

Technical information

TDR Targets ID: 1441628
Name: N-[3-[(2,5-diethoxy-4-morpholin-4-ylphenyl)su lfamoyl]-4-methoxyphenyl]acetamide
MW: 493.573 | Formula: C23H31N3O7S
H donors: 2 H acceptors: 3 LogP: 2.02 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1cc(N2CCOCC2)c(cc1NS(=O)(=O)c1cc(ccc1OC)NC(=O)C)OCC
InChi: 1S/C23H31N3O7S/c1-5-32-21-15-19(26-9-11-31-12-10-26)22(33-6-2)14-18(21)25-34(28,29)23-13-17(24-16(3)27)7-8-20(23)30-4/h7-8,13-15,25H,5-6,9-12H2,1-4H3,(H,24,27)
InChiKey: MGEUVJZNEDBNAB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[3-[(2,5-diethoxy-4-morpholino-phenyl)sulfamoyl]-4-methoxy-phenyl]acetamide
N-[3-[(2,5-diethoxy-4-morpholinophenyl)sulfamoyl]-4-methoxyphenyl]acetamide
N-[3-[(2,5-diethoxy-4-morpholin-4-yl-phenyl)sulfamoyl]-4-methoxy-phenyl]ethanamide
T5367683

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references
Giardia intestinalis	Putative fructose-1,6-bisphosphate aldolase	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references
Homo sapiens	multiple endocrine neoplasia I		No references
Homo sapiens	glucosidase, alpha	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus		Get druggable targets OG5_127055	All targets in OG5_127055
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Treponema pallidum	fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	Menin, putative	Get druggable targets OG5_133913	All targets in OG5_133913
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_133913	All targets in OG5_133913
Echinococcus granulosus	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Brugia malayi	Glycosyl hydrolases family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	ko:K01187 alpha-glucosidase [EC3.2.1.20], putative	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Schistosoma japonicum	Lysosomal alpha-glucosidase precursor, putative	Get druggable targets OG5_127055	All targets in OG5_127055
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Giardia lamblia	Fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus granulosus	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.8 %
Mycobacterium ulcerans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	26.9 %
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.5 %
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.7095	1
Echinococcus multilocularis	tubulin alpha	0.0097	0.1823	0.1823
Toxoplasma gondii	alpha tubulin TUBA1	0.0097	0.1823	0.2648
Schistosoma mansoni	alpha-glucosidase	0.0169	0.3312	0.3312
Loa Loa (eye worm)	tubulin gamma chain	0.0097	0.1823	0.3616
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0722	0.0814
Schistosoma mansoni	tubulin subunit alpha	0.0042	0.0691	0.0691
Trichomonas vaginalis	tubulin beta chain, putative	0.0097	0.1823	0.2401
Onchocerca volvulus		0.0035	0.0537	0.1889
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.0722	0.0814
Echinococcus multilocularis	tubulin alpha 1C chain	0.0097	0.1823	0.1823
Entamoeba histolytica	tubulin alpha chain, putative	0.0097	0.1823	0.2401
Onchocerca volvulus		0.0055	0.0954	0.3966
Trichomonas vaginalis	tubulin beta chain, putative	0.0055	0.0954	0.1149
Trypanosoma cruzi	alpha tubulin, putative	0.0097	0.1823	0.3464
Trichomonas vaginalis	tubulin epsilon chain, putative	0.025	0.4965	0.693
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0158	0.0232
Schistosoma mansoni	tubulin subunit epsilon	0.0097	0.1823	0.1823
Plasmodium falciparum	alpha tubulin 2	0.0097	0.1823	0.2648
Toxoplasma gondii	beta-tubulin, putative	0.025	0.4965	1
Leishmania major	alpha tubulin	0.0097	0.1823	0.3464
Echinococcus granulosus	tubulin alpha 3 chain	0.0097	0.1823	0.1823
Leishmania major	beta tubulin	0.025	0.4965	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0722	0.1174
Brugia malayi	Tubulin alpha-2 chain	0.0097	0.1823	0.3619
Echinococcus multilocularis	tubulin alpha chain	0.0097	0.1823	0.1823
Echinococcus multilocularis	tubulin delta chain	0.0042	0.0691	0.0691
Entamoeba histolytica	tubulin family protein	0.025	0.4965	0.693
Leishmania major	beta tubulin	0.025	0.4965	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0044	0.0722	0.1383
Leishmania major	beta tubulin	0.025	0.4965	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0044	0.0722	0.0814
Echinococcus multilocularis	peroxisome assembly protein 26	0.0097	0.1823	0.1823
Echinococcus multilocularis	tubulin alpha 1C chain	0.0097	0.1823	0.1823
Plasmodium vivax	tubulin alpha chain, putative	0.0097	0.1823	0.2648
Giardia lamblia	Fructose-bisphosphate aldolase	0.0353	0.7095	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0097	0.1823	0.1823
Trypanosoma brucei	glucosidase, putative	0.0044	0.0722	0.1174
Trypanosoma brucei	zeta tubulin, putative	0.0042	0.0691	0.111
Trypanosoma brucei	alpha tubulin	0.0097	0.1823	0.3464
Trypanosoma brucei	tubulin delta chain	0.0042	0.0691	0.111
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0042	0.0691	0.1316
Trypanosoma brucei	zeta tubulin	0.0042	0.0691	0.111
Plasmodium falciparum	tubulin beta chain	0.025	0.4965	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.025	0.4965	1
Echinococcus multilocularis	tubulin alpha chain	0.0097	0.1823	0.1823
Leishmania major	alpha tubulin	0.0097	0.1823	0.3464
Schistosoma mansoni	cpg binding protein	0.0035	0.0537	0.0537
Echinococcus multilocularis	tubulin beta 1 chain	0.025	0.4965	0.4965
Leishmania major	beta tubulin	0.025	0.4965	1
Trypanosoma cruzi	tubulin delta chain	0.0042	0.0691	0.111
Trichomonas vaginalis	tubulin, putative	0.025	0.4965	0.693
Trypanosoma brucei	beta tubulin	0.025	0.4965	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.7095	1
Schistosoma mansoni	tubulin subunit beta	0.025	0.4965	0.4965
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0097	0.1823	0.1823
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.1338	0.1338
Loa Loa (eye worm)	BEN-1 protein	0.025	0.4965	1
Giardia lamblia	Beta tubulin	0.025	0.4965	0.6675
Plasmodium falciparum	tubulin gamma chain	0.0097	0.1823	0.2648
Echinococcus multilocularis	tubulin subunit TubB	0.0097	0.1823	0.1823
Echinococcus multilocularis	tubulin alpha chain	0.0097	0.1823	0.1823
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0691	0.1316
Trypanosoma brucei	beta tubulin	0.025	0.4965	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.0722	0.0814
Echinococcus granulosus	tubulin alpha chain	0.0097	0.1823	0.1823
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0537	0.1003
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.7095	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.7095	1
Schistosoma mansoni	alpha tubulin	0.0097	0.1823	0.1823
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0097	0.1823	0.1823
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0691	0.0769
Plasmodium vivax	tubulin epsilon chain, putative	0.0097	0.1823	0.2648
Loa Loa (eye worm)	tubulin beta chain	0.025	0.4965	1
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0097	0.1823	0.3616
Echinococcus multilocularis	beta tubulin	0.025	0.4965	0.4965
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.7095	1
Trichomonas vaginalis	tubulin, putative	0.0055	0.0954	0.1149
Leishmania major	beta tubulin	0.025	0.4965	1
Schistosoma mansoni	tubulin subunit beta	0.025	0.4965	0.4965
Brugia malayi	tubulin alpha-2 chain	0.0097	0.1823	0.3619
Echinococcus multilocularis	dnaJ subfamily B	0.0494	1	1
Trypanosoma brucei	alpha tubulin	0.0097	0.1823	0.3464
Leishmania major	beta tubulin	0.025	0.4965	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0097	0.1823	0.2401
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0197	0.3876	0.7789
Brugia malayi	Cell division protein ftsZ	0.0042	0.0691	0.1321
Leishmania major	beta tubulin	0.025	0.4965	1
Loa Loa (eye worm)	tubulin alpha 2	0.0055	0.0954	0.1851
Trypanosoma brucei	beta tubulin	0.0097	0.1823	0.3464
Trypanosoma brucei	epsilon tubulin	0.0097	0.1823	0.3464
Echinococcus granulosus	beta tubulin	0.025	0.4965	0.4965
Leishmania major	alpha tubulin	0.0097	0.1823	0.3464
Schistosoma mansoni	cpg binding protein	0.0037	0.0578	0.0578
Entamoeba histolytica	tubulin family protein	0.025	0.4965	0.693
Echinococcus granulosus	tubulin alpha 1C chain	0.0097	0.1823	0.1823
Brugia malayi	tubulin alpha chain - mouse	0.0097	0.1823	0.3619
Brugia malayi	alpha-tubulin	0.0097	0.1823	0.3619
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.7095	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0722	0.0814
Plasmodium vivax	tubulin gamma chain, putative	0.0097	0.1823	0.2648
Schistosoma mansoni	tubulin subunit beta	0.025	0.4965	0.4965
Trichomonas vaginalis	tubulin beta chain, putative	0.0097	0.1823	0.2401
Leishmania major	alpha tubulin	0.0097	0.1823	0.3464
Echinococcus granulosus	tubulin alpha chain	0.0097	0.1823	0.1823
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0044	0.0722	0.0722
Leishmania major	alpha tubulin	0.0097	0.1823	0.3464
Echinococcus granulosus	tubulin alpha	0.0097	0.1823	0.1823
Schistosoma mansoni	tubulin subunit delta	0.0042	0.0691	0.0691
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0044	0.0044
Trypanosoma cruzi	zeta tubulin, putative	0.0042	0.0691	0.111
Leishmania major	gamma-tubulin	0.0097	0.1823	0.3464
Trypanosoma brucei	epsilon tubulin	0.0097	0.1823	0.3464
Echinococcus multilocularis	tubulin alpha 3 chain	0.0097	0.1823	0.1823
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0044	0.0722	0.0814
Trichomonas vaginalis	tubulin gamma chain, putative	0.025	0.4965	0.693
Leishmania major	alpha tubulin	0.0097	0.1823	0.3464
Schistosoma mansoni	tubulin subunit alpha	0.0097	0.1823	0.1823
Echinococcus granulosus	Tubulin beta 2C chain	0.025	0.4965	0.4965
Echinococcus granulosus	peroxisome assembly protein 26	0.0097	0.1823	0.1823
Treponema pallidum	fructose-bisphosphate aldolase	0.0353	0.7095	1
Echinococcus granulosus	cpg binding protein	0.0037	0.0578	0.0578
Trypanosoma cruzi	beta tubulin, putative	0.025	0.4965	1
Plasmodium vivax	tubulin beta chain, putative	0.025	0.4965	1
Schistosoma mansoni	alpha tubulin	0.0097	0.1823	0.1823
Leishmania major	alpha tubulin	0.0097	0.1823	0.3464
Echinococcus granulosus	alpha tubulin	0.0097	0.1823	0.1823
Echinococcus granulosus	tubulin alpha chain	0.0097	0.1823	0.1823
Loa Loa (eye worm)	tubulin beta chain	0.0042	0.0691	0.1316
Echinococcus granulosus	tubulin beta 1 chain	0.025	0.4965	0.4965
Echinococcus multilocularis	tubulin gamma 1 chain	0.0097	0.1823	0.1823
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.7095	1
Echinococcus granulosus	beta tubulin	0.025	0.4965	0.4965
Brugia malayi	Tubulin beta chain	0.0042	0.0691	0.1321
Echinococcus granulosus	tubulin subunit TubB	0.0097	0.1823	0.1823
Echinococcus multilocularis	cpg binding protein	0.0037	0.0578	0.0578
Entamoeba histolytica	tubulin gamma chain	0.0097	0.1823	0.2401
Brugia malayi	Tubulin alpha chain	0.0042	0.0691	0.1321
Echinococcus granulosus	Tubulin beta 2C chain	0.025	0.4965	0.4965
Giardia lamblia	Alpha-tubulin	0.0097	0.1823	0.1768
Echinococcus granulosus	tubulin gamma 1 chain	0.0097	0.1823	0.1823
Schistosoma mansoni	tubulin subunit gamma	0.0097	0.1823	0.1823
Loa Loa (eye worm)	tubulin alpha 2	0.0055	0.0954	0.1851
Trypanosoma brucei	alpha tubulin, putative	0.0055	0.0954	0.1658
Echinococcus granulosus	tubulin beta 4A class IVa	0.025	0.4965	0.4965
Trypanosoma brucei	beta tubulin	0.025	0.4965	1
Giardia lamblia	Beta tubulin	0.025	0.4965	0.6675
Leishmania major	alpha tubulin	0.0097	0.1823	0.3464
Brugia malayi	Tubulin beta chain	0.0055	0.0954	0.1855
Leishmania major	epsilon tubulin, putative	0.0097	0.1823	0.3464
Trichomonas vaginalis	tubulin epsilon chain, putative	0.025	0.4965	0.693
Trichomonas vaginalis	tubulin alpha chain, putative	0.0055	0.0954	0.1149
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0016	0.0158	0.0237
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0722	0.0814
Trichomonas vaginalis	tubulin, putative	0.0055	0.0954	0.1149
Echinococcus granulosus	tubulin alpha chain	0.0097	0.1823	0.1823
Echinococcus granulosus	Tubulin beta 2C chain	0.025	0.4965	0.4965
Leishmania major	zeta tubulin, putative	0.0042	0.0691	0.111
Loa Loa (eye worm)	hypothetical protein	0.0097	0.1823	0.3616
Leishmania major	delta tubulin, putative	0.0042	0.0691	0.111
Plasmodium falciparum	alpha tubulin 1	0.0097	0.1823	0.2648
Trypanosoma brucei	epsilon tubulin	0.0097	0.1823	0.3464
Echinococcus multilocularis	tubulin alpha chain	0.0097	0.1823	0.1823
Schistosoma mansoni	tubulin subunit beta	0.0042	0.0691	0.0691
Schistosoma mansoni	hypothetical protein	0.0494	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.025	0.4965	0.4965
Giardia lamblia	Gamma tubulin	0.0097	0.1823	0.1768
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0055	0.0954	0.1149
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0055	0.0954	0.1149
Trichomonas vaginalis	tubulin, putative	0.0042	0.0691	0.0769
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.025	0.4965	0.4965
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0042	0.0691	0.0769
Schistosoma mansoni	tubulin subunit alpha	0.0097	0.1823	0.1823
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0172	0.3375	1
Echinococcus granulosus	tubulin epsilon chain	0.0097	0.1823	0.1823
Giardia lamblia	Beta tubulin	0.025	0.4965	0.6675
Trichomonas vaginalis	tubulin gamma chain, putative	0.0097	0.1823	0.2401
Loa Loa (eye worm)	beta-tubulin	0.025	0.4965	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0097	0.1823	0.2401
Leishmania major	alpha tubulin	0.0097	0.1823	0.3464
Schistosoma mansoni	alpha-glucosidase	0.0169	0.3312	0.3312
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0097	0.1823	0.2648
Echinococcus multilocularis	beta tubulin	0.025	0.4965	0.4965
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0044	0.0722	0.1378
Trichomonas vaginalis	tubulin alpha chain, putative	0.0055	0.0954	0.1149
Echinococcus granulosus	tubulin alpha chain	0.0097	0.1823	0.1823
Loa Loa (eye worm)	tubulin beta-4 chain	0.025	0.4965	1
Leishmania major	alpha glucosidase II subunit, putative	0.0044	0.0722	0.1174
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0097	0.1823	0.1823
Plasmodium falciparum	tubulin epsilon chain, putative	0.0097	0.1823	0.2648
Brugia malayi	Tubulin gamma chain	0.0097	0.1823	0.3619
Trichomonas vaginalis	tubulin beta chain, putative	0.025	0.4965	0.693
Echinococcus multilocularis	Tubulin beta 2C chain	0.025	0.4965	0.4965
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0097	0.1823	0.2401
Leishmania major	beta tubulin	0.025	0.4965	1
Trypanosoma brucei	alpha tubulin	0.0097	0.1823	0.3464
Trichomonas vaginalis	tubulin gamma chain, putative	0.0042	0.0691	0.0769
Echinococcus multilocularis	Tubulin beta 2C chain	0.025	0.4965	0.4965
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.7095	1
Trypanosoma cruzi	tubulin delta chain	0.0042	0.0691	0.111
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0954	0.1851
Echinococcus granulosus	Tubulin alpha 1 chain	0.0097	0.1823	0.1823
Brugia malayi	Tubulin beta-1 chain	0.025	0.4965	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0097	0.1823	0.1823
Echinococcus multilocularis	tubulin alpha chain	0.0097	0.1823	0.1823
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0172	0.3375	1
Schistosoma mansoni	tubulin subunit beta	0.025	0.4965	0.4965
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0042	0.0691	0.5
Toxoplasma gondii	beta tubulin	0.025	0.4965	1
Echinococcus granulosus	lysosomal alpha glucosidase	0.0197	0.3876	0.3876
Leishmania major	beta tubulin	0.025	0.4965	1
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0172	0.3375	1
Loa Loa (eye worm)	BEN-1 protein	0.025	0.4965	1
Echinococcus multilocularis	tubulin subunit beta	0.025	0.4965	0.4965
Loa Loa (eye worm)	tubulin alpha chain	0.0097	0.1823	0.3616
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0044	0.0044
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.7095	1
Echinococcus granulosus	neutral alpha glucosidase AB	0.0044	0.0722	0.0722
Leishmania major	alpha tubulin	0.0097	0.1823	0.3464
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.3876	0.3876
Leishmania major	beta tubulin	0.025	0.4965	1
Leishmania major	alpha tubulin	0.0097	0.1823	0.3464
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0722	0.0814
Brugia malayi	beta-tubulin, identical	0.025	0.4965	1
Leishmania major	beta tubulin	0.025	0.4965	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0097	0.1823	0.1823
Trichomonas vaginalis	tubulin beta chain, putative	0.0097	0.1823	0.2401
Echinococcus multilocularis	tubulin epsilon chain	0.0097	0.1823	0.1823
Loa Loa (eye worm)	alpha-tubulin	0.0097	0.1823	0.3616
Trypanosoma brucei	tubulin gamma chain	0.0097	0.1823	0.3464
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0722	0.0814
Schistosoma mansoni	tubulin subunit alpha	0.0097	0.1823	0.1823
Leishmania major	beta tubulin	0.025	0.4965	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.025	0.4965	0.693
Trypanosoma brucei	beta tubulin	0.025	0.4965	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0097	0.1823	0.2401
Leishmania major	beta tubulin	0.025	0.4965	1
Schistosoma mansoni	tubulin subunit beta	0.025	0.4965	0.4965
Brugia malayi	Tubulin alpha chain	0.0097	0.1823	0.3619
Echinococcus multilocularis	hypothetical protein	0.0097	0.1823	0.1823
Leishmania major	beta tubulin	0.025	0.4965	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0042	0.0691	0.0769
Entamoeba histolytica	tubulin alpha-1 chain	0.0097	0.1823	0.2401
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0722	0.0814
Leishmania major	beta tubulin	0.025	0.4965	1
Echinococcus granulosus	Tubulin beta 2C chain	0.025	0.4965	0.4965
Toxoplasma gondii	alpha-tubulin I, putative	0.0097	0.1823	0.2648
Schistosoma mansoni	alpha glucosidase	0.0044	0.0722	0.0722
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0722	0.0814
Trichomonas vaginalis	tubulin beta chain, putative	0.0097	0.1823	0.2401
Trichomonas vaginalis	tubulin alpha chain, putative	0.0097	0.1823	0.2401
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0042	0.0691	0.0769
Echinococcus granulosus	Tubulin alpha 1 chain	0.0097	0.1823	0.1823
Loa Loa (eye worm)	tubulin beta-2A chain	0.025	0.4965	1
Trypanosoma cruzi	tubulin gamma chain	0.0097	0.1823	0.3464
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0691	0.0769
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0197	0.3876	0.7787
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0537	0.1008
Trichomonas vaginalis	tubulin alpha chain, putative	0.0055	0.0954	0.1149
Leishmania major	beta tubulin	0.025	0.4965	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.7095	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.3876	0.3876
Leishmania major	beta tubulin	0.025	0.4965	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0097	0.1823	0.2401
Trypanosoma cruzi	epsilon tubulin, putative	0.0097	0.1823	0.3464
Echinococcus multilocularis	Tubulin beta 2C chain	0.025	0.4965	0.4965
Giardia lamblia	Alpha-tubulin	0.0097	0.1823	0.1768
Echinococcus granulosus	tubulin subunit beta	0.025	0.4965	0.4965
Toxoplasma gondii	beta-1 tubulin, putative	0.025	0.4965	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.1176	0.1135
Trypanosoma cruzi	zeta tubulin, putative	0.0042	0.0691	0.111
Loa Loa (eye worm)	tubulin alpha chain	0.0097	0.1823	0.3616
Echinococcus granulosus	tubulin delta chain	0.0042	0.0691	0.0691
Leishmania major	alpha tubulin	0.0097	0.1823	0.3464
Echinococcus multilocularis	tubulin alpha 3 chain	0.0097	0.1823	0.1823
Schistosoma mansoni	tubulin subunit beta	0.025	0.4965	0.4965
Onchocerca volvulus		0.0114	0.2167	1
Brugia malayi	Tubulin alpha-2 chain	0.0097	0.1823	0.3619
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0055	0.0954	0.1851
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0722	0.1174
Plasmodium vivax	tubulin alpha chain, putative	0.0097	0.1823	0.2648
Echinococcus multilocularis	Tubulin beta 2C chain	0.025	0.4965	0.4965
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0044	0.0722	0.0072
Trypanosoma cruzi	epsilon tubulin, putative	0.0097	0.1823	0.3464
Loa Loa (eye worm)	alpha-tubulin	0.0097	0.1823	0.3616
Schistosoma mansoni	alpha tubulin	0.0097	0.1823	0.1823
Echinococcus granulosus	Tubulin beta 2C chain	0.025	0.4965	0.4965
Leishmania major	beta tubulin	0.025	0.4965	1
Schistosoma mansoni	cpg binding protein	0.0037	0.0578	0.0578
Trichomonas vaginalis	tubulin gamma chain, putative	0.0097	0.1823	0.2401
Trypanosoma brucei	alpha tubulin	0.0097	0.1823	0.3464

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (binding)	34.46 uM	PubChem BioAssay. VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 5.6234 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	6.3096 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ]	ChEMBL.	No reference
Potency (functional)	21.3313 uM	PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	33.8078 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636]	ChEMBL.	No reference
Potency (functional)	70.7946 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	= 79.4328 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1603262

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1441628