Detailed information for compound 1458794

Basic information

Technical information
  • TDR Targets ID: 1458794
  • Name: N-methyl-2-[4-[(4-methylphthalazin-1-yl)amino ]phenoxy]acetamide hydrochloride
  • MW: 358.822 | Formula: C18H19ClN4O2
  • H donors: 2 H acceptors: 3 LogP: 3.49 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)COc1ccc(cc1)Nc1nnc(c2c1cccc2)C.Cl
  • InChi: 1S/C18H18N4O2.ClH/c1-12-15-5-3-4-6-16(15)18(22-21-12)20-13-7-9-14(10-8-13)24-11-17(23)19-2;/h3-10H,11H2,1-2H3,(H,19,23)(H,20,22);1H
  • InChiKey: GVKOELPARUDOKU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-methyl-2-[4-[(4-methyl-1-phthalazinyl)amino]phenoxy]acetamide hydrochloride
  • N-methyl-2-[4-[(4-methylphthalazin-1-yl)amino]phenoxy]ethanamide hydrochloride
  • MLS001044419
  • N-Methyl-2-[4-(4-methyl-phthalazin-1-ylamino)-phenoxy]-acetamide
  • SMR000424778

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis malate dehydrogenase, putative 0.0095 0.4349 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0095 0.4349 1
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0095 0.4349 0.4349
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.3099 0.3048
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.3986 0.8837
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.2316 0.5247
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.011 0.5127 0.5127
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0889 0.1213
Entamoeba histolytica cysteine protease, putative 0.0029 0.0889 0.1213
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0466 0.092
Loa Loa (eye worm) hypothetical protein 0.0126 0.5984 0.5984
Leishmania major malate dehydrogenase, putative 0.0126 0.5984 0.5955
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0466 0.0888
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0202 1 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0466 0.092
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0038 0.0038
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0466 0.0485
Loa Loa (eye worm) hypothetical protein 0.0056 0.2316 0.2316
Giardia lamblia Malate dehydrogenase 0.0095 0.4349 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0738 0.067
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0466 0.0396
Entamoeba histolytica cysteine protease, putative 0.0029 0.0889 0.1213
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0073 0.0121
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0466 0.0888
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0073 0.0167
Plasmodium falciparum thioredoxin reductase 0.0013 0.0073 0.0121
Loa Loa (eye worm) hypothetical protein 0.011 0.5127 0.5127
Chlamydia trachomatis malate dehydrogenase 0.0095 0.4349 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0466 0.0665
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0073 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.2316 0.5247
Plasmodium vivax unspecified product 0.0029 0.0889 0.138
Echinococcus granulosus lamin 0.0026 0.0752 0.0752
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.2316 0.5247
Trichomonas vaginalis malate dehydrogenase, putative 0.0095 0.4349 1
Echinococcus granulosus cathepsin l1 0.0038 0.1343 0.1343
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0466 0.0888
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.2316 0.5247
Echinococcus granulosus lactate dehydrogenase a 0.0126 0.5984 0.5984
Plasmodium vivax lactate dehydrogenase 0.0126 0.5984 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.1343 0.1343
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0466 0.092
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.1395 0.2236
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0466 0.092
Trypanosoma cruzi cysteine proteinase, putative 0.0029 0.0889 0.0822
Plasmodium vivax vivapain-2 0.0056 0.2316 0.3795
Entamoeba histolytica cysteine protease, putative 0.0029 0.0889 0.1213
Brugia malayi lactate dehydrogenase. 0.0126 0.5984 0.5984
Leishmania major carbonic anhydrase-like protein 0.0202 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0056 0.2316 0.2316
Loa Loa (eye worm) hypothetical protein 0.0026 0.0752 0.0752
Brugia malayi glutathione reductase 0.0039 0.1395 0.1395
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0466 0.092
Trypanosoma brucei trypanothione reductase 0.0039 0.1395 0.1332
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.1343 0.297
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.011 0.5127 0.5127
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0095 0.4349 0.4349
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.7301 0.7281
Entamoeba histolytica malate dehydrogenase, putative 0.0095 0.4349 0.718
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0056 0.2316 0.2316
Loa Loa (eye worm) hypothetical protein 0.011 0.5127 0.5127
Echinococcus multilocularis lactate dehydrogenase a 0.0126 0.5984 0.5984
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.2005 0.4362
Onchocerca volvulus 0.0026 0.0752 0.1088
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0088 0.4001 0.3957
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0185 0.0113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.7301 0.7281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.0889 0.0822
Trichomonas vaginalis malate dehydrogenase, putative 0.0095 0.4349 1
Echinococcus multilocularis lactate dehydrogenase protein 0.0126 0.5984 0.5984
Loa Loa (eye worm) hypothetical protein 0.0053 0.2157 0.2157
Loa Loa (eye worm) malate dehydrogenase 0.0088 0.4001 0.4001
Echinococcus multilocularis malate dehydrogenase 0.0088 0.4001 0.4001
Trichomonas vaginalis malate dehydrogenase, putative 0.0095 0.4349 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0466 0.0396
Echinococcus granulosus carbonic anhydrase 0.011 0.5127 0.5127
Trichomonas vaginalis malate dehydrogenase, putative 0.007 0.3074 0.7018
Entamoeba histolytica cysteine protease, putative 0.0029 0.0889 0.1213
Loa Loa (eye worm) hypothetical protein 0.0038 0.1343 0.1343
Echinococcus granulosus intermediate filament protein 0.0026 0.0752 0.0752
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0894 0.192
Brugia malayi Cathepsin L-like cysteine proteinase 0.0038 0.1343 0.1343
Loa Loa (eye worm) hypothetical protein 0.0053 0.2157 0.2157
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.011 0.5127 0.5127
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.1395 0.2985
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0466 0.0888
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.2316 0.5247
Echinococcus multilocularis cysteine protease 0.0056 0.2316 0.2316
Echinococcus multilocularis carbonic anhydrase 0.011 0.5127 0.5127
Echinococcus multilocularis carbonic anhydrase II 0.0202 1 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0738 0.1555
Entamoeba histolytica malate dehydrogenase, putative 0.0126 0.5984 1
Entamoeba histolytica cysteine protease, putative 0.0029 0.0889 0.1213
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0738 0.1233
Trypanosoma brucei carbonic anhydrase-like protein 0.0202 1 1
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0466 0.0779
Loa Loa (eye worm) oxidoreductase 0.0021 0.0466 0.0466
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0095 0.4349 0.4349
Brugia malayi Cathepsin L-like precursor 0.0056 0.2316 0.2316
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0894 0.0894
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0466 0.0466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.7301 0.7281
Brugia malayi Cathepsin L-like precursor 0.0056 0.2316 0.2316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.2316 0.5247
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.1343 0.1997
Onchocerca volvulus Cathepsin L homolog 0.0056 0.2316 0.7028
Brugia malayi Cathepsin L-like precursor 0.0056 0.2316 0.2316
Schistosoma mansoni lamin 0.0026 0.0752 0.0752
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.7301 0.7281
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0202 1 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0095 0.4349 1
Schistosoma mansoni malate dehydrogenase 0.0095 0.4349 0.4349
Brugia malayi cathepsin F-like cysteine proteinase 0.0019 0.0345 0.0345
Loa Loa (eye worm) fibroinase 0.0056 0.2316 0.2316
Onchocerca volvulus 0.0056 0.2316 0.7028
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0185 0.0113
Trypanosoma brucei cytosolic malate dehydrogenase 0.0095 0.4349 0.4308
Trypanosoma cruzi malate dehydrogenase, putative 0.007 0.3074 0.3023
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0466 0.0396
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.4501 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0466 0.0396
Onchocerca volvulus 0.0038 0.1343 0.333
Entamoeba histolytica cysteine protease, putative 0.0056 0.2316 0.3675
Entamoeba histolytica cysteine protease, putative 0.0029 0.0889 0.1213
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.2316 0.226
Trichomonas vaginalis malate dehydrogenase, putative 0.0034 0.1175 0.2578
Echinococcus multilocularis cathepsin L cysteine protease 0.0056 0.2316 0.2316
Schistosoma mansoni L-lactate dehydrogenase 0.0126 0.5984 0.5984
Onchocerca volvulus 0.0056 0.2316 0.7028
Onchocerca volvulus 0.0056 0.2316 0.7028
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0088 0.4001 0.3957
Entamoeba histolytica cysteine protease, putative 0.0029 0.0889 0.1213
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0466 0.0888
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0088 0.4001 0.3957
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0466 0.092
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0738 0.0738
Schistosoma mansoni flap endonuclease-1 0.0024 0.0606 0.0606
Trichomonas vaginalis malate dehydrogenase, putative 0.0095 0.4349 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.7301 0.7281
Echinococcus multilocularis lactate dehydrogenase a 0.0126 0.5984 0.5984
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0073 0.0073
Echinococcus granulosus cathepsin l cysteine peptidase 0.0056 0.2316 0.2316
Treponema pallidum NADH oxidase 0.0013 0.0073 0.5
Brugia malayi Flap endonuclease-1 0.0026 0.0738 0.0738
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0056 0.2316 0.3871
Leishmania major malate dehydrogenase, putative 0.007 0.3074 0.3023
Schistosoma mansoni cathepsin F (C01 family) 0.0056 0.2316 0.2316
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0073 0.0121
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0466 0.0466
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.2316 0.3675
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0095 0.4349 0.9622
Leishmania major cathepsin L-like protease 0.0056 0.2316 0.226
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.011 0.5127 0.5127
Loa Loa (eye worm) hypothetical protein 0.0013 0.0038 0.0038
Plasmodium vivax malate dehydrogenase, putative 0.0126 0.5984 1
Schistosoma mansoni carbonic anhydrase-related 0.011 0.5127 0.5127
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.3099 0.5025
Onchocerca volvulus Cathepsin L homolog 0.0056 0.2316 0.7028
Loa Loa (eye worm) hypothetical protein 0.0019 0.0345 0.0345
Echinococcus granulosus L lactate dehydrogenase 0.0055 0.2282 0.2282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.2316 0.5247
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.7301 0.7281
Plasmodium falciparum carbonic anhydrase 0.011 0.5127 0.8568
Trichomonas vaginalis malate dehydrogenase, putative 0.0059 0.245 0.5561
Schistosoma mansoni intermediate filament proteins 0.0026 0.0752 0.0752
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0029 0.0889 0.0822
Echinococcus granulosus cytosolic malate dehydrogenase 0.0095 0.4349 0.4349
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.3099 0.3048
Echinococcus granulosus cathepsin l1 0.0056 0.2316 0.2316
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0889 0.1213
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0056 0.2316 0.2316
Brugia malayi Cathepsin L-like precursor 0.0056 0.2316 0.2316
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0752 0.0752
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.2316 0.5247
Leishmania major malate dehydrogenase 0.0088 0.4001 0.3957
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0111 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0056 0.2316 0.5247
Trichomonas vaginalis malate dehydrogenase, putative 0.0095 0.4349 1
Brugia malayi Cathepsin L-like precursor 0.0038 0.1343 0.1343
Plasmodium falciparum cysteine proteinase falcipain 3 0.0056 0.2316 0.3871
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.2316 0.5247
Echinococcus granulosus cathepsin L cysteine protease 0.0029 0.0889 0.0889
Leishmania major trypanothione reductase 0.0039 0.1395 0.1332
Loa Loa (eye worm) glutathione reductase 0.0039 0.1395 0.1395
Trypanosoma cruzi cruzipain precursor, putative 0.0019 0.0345 0.0274
Plasmodium falciparum thioredoxin reductase 0.0039 0.1395 0.2331
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.2316 0.5247
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.0889 0.0889
Leishmania major cytosolic malate dehydrogenase 0.0095 0.4349 0.4308
Loa Loa (eye worm) carbonic anhydrase 3 0.0202 1 1
Toxoplasma gondii malate dehydrogenase MDH 0.0126 0.5984 1
Entamoeba histolytica cysteine protease, putative 0.0029 0.0889 0.1213
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0894 0.0894
Echinococcus multilocularis malate dehydrogenase 0.0088 0.4001 0.4001
Trypanosoma cruzi cruzipain precursor, putative 0.0151 0.7301 0.7281
Trypanosoma cruzi malate dehydrogenase, putative 0.0088 0.4001 0.3957
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.2316 0.5247
Onchocerca volvulus 0.0056 0.2316 0.7028
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0466 0.0466
Leishmania major mitochondrial malate dehydrogenase 0.0088 0.4001 0.3957
Echinococcus multilocularis carbonic anhydrase 0.011 0.5127 0.5127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.2316 0.5247
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.3099 0.7077
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0202 1 1
Echinococcus granulosus lactate dehydrogenase a 0.0126 0.5984 0.5984
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0466 0.092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.2316 0.5247
Loa Loa (eye worm) hypothetical protein 0.0021 0.0466 0.0466
Echinococcus granulosus lactate dehydrogenase protein 0.0126 0.5984 0.5984
Onchocerca volvulus 0.0026 0.0752 0.1088
Mycobacterium tuberculosis Probable reductase 0.0088 0.3986 0.8837
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.2157 0.3604
Leishmania major cathepsin L-like protease 0.0151 0.7301 0.7281
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0095 0.4349 0.4308
Trichomonas vaginalis malate dehydrogenase, putative 0.0095 0.4349 1
Plasmodium vivax glutathione reductase, putative 0.0039 0.1395 0.2236
Loa Loa (eye worm) hypothetical protein 0.0053 0.2157 0.2157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.2316 0.5247
Entamoeba histolytica cysteine proteinase 1, putative 0.0029 0.0889 0.1213
Trypanosoma brucei glycosomal malate dehydrogenase 0.0088 0.4001 0.3957
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0466 0.092
Toxoplasma gondii cathepsin CPL 0.0056 0.2316 0.3871
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.2157 0.4873
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0466 0.0779
Leishmania major cysteine peptidase A (CPA) 0.0056 0.2316 0.226
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.3099 0.6833
Brugia malayi intermediate filament protein 0.0026 0.0752 0.0752
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0889 0.1213
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0466 0.0888
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0466 0.0466
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0466 0.0396
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0389 0.065
Plasmodium falciparum lactate dehydrogenase, putative 0.007 0.3074 0.5136
Echinococcus granulosus cytosolic malate dehydrogenase 0.0095 0.4349 0.4349
Schistosoma mansoni carbonic anhydrase-related 0.011 0.5127 0.5127
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.3099 0.6525
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0466 0.092
Schistosoma mansoni carbonic anhydrase 0.011 0.5127 0.5127
Plasmodium vivax vivapain-1 0.0029 0.0889 0.138
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0466 0.0888
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.3099 0.7077
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.3986 0.8837
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0466 0.0888
Entamoeba histolytica cysteine protease, putative 0.0029 0.0889 0.1213
Loa Loa (eye worm) ctsf protein 0.0056 0.2316 0.2316
Schistosoma mansoni malate dehydrogenase 0.0095 0.4349 0.4349
Trypanosoma cruzi cysteine peptidase, putative 0.0151 0.7301 0.7281
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0466 0.0466
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.0038 0.1343 0.1343
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0466 0.0779
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0345 0.0274
Onchocerca volvulus 0.0071 0.3099 1
Trypanosoma brucei malate dehydrogenase-related 0.007 0.3074 0.3023
Plasmodium vivax lactate/malate dehydrogenase, putative 0.007 0.3074 0.5076
Loa Loa (eye worm) hypothetical protein 0.0071 0.3099 0.3099
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.3099 0.5025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0466 0.0466
Leishmania major cathepsin L-like protease 0.0056 0.2316 0.226
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0132 0.6327 0.63
Loa Loa (eye worm) hypothetical protein 0.0019 0.0345 0.0345
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0466 0.0466
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0709 0.1185
Echinococcus granulosus malate dehydrogenase 0.0088 0.4001 0.4001
Plasmodium falciparum glutathione reductase 0.0039 0.1395 0.2331
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0053 0.2157 0.2157
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.2316 0.3675
Plasmodium vivax vivapain-3 0.0029 0.0889 0.138
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0894 0.192
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.4501 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0401 0.0555
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0202 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.2316 0.5247
Plasmodium falciparum glutathione reductase 0.0013 0.0073 0.0121
Plasmodium vivax vivapain-2 0.0056 0.2316 0.3795
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0466 0.092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.2316 0.5247
Entamoeba histolytica cysteine protease, putative 0.0029 0.0889 0.1213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0889 0.1908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.7301 0.7281
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.3099 0.6525
Plasmodium falciparum cysteine proteinase falcipain 1 0.0029 0.0889 0.1485
Echinococcus granulosus cathepsin L cysteine proteinase 0.0056 0.2316 0.2316
Echinococcus multilocularis cathepsin L cysteine protease 0.0056 0.2316 0.2316
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0071 0.3099 0.7077
Echinococcus multilocularis cathepsin L 0.0029 0.0889 0.0889
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0738 0.1125
Brugia malayi Papain family cysteine protease containing protein 0.0056 0.2316 0.2316
Leishmania major cathepsin L-like protease 0.0056 0.2316 0.226
Leishmania major glycosomal malate dehydrogenase 0.0088 0.4001 0.3957
Entamoeba histolytica cysteine protease, putative 0.0029 0.0889 0.1213
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0466 0.0466
Trichomonas vaginalis malate dehydrogenase, putative 0.0095 0.4349 1
Echinococcus granulosus cysteine protease 0.0029 0.0889 0.0889
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.2005 0.4362
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0466 0.092
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0056 0.2316 0.3871
Echinococcus multilocularis lamin dm0 0.0026 0.0752 0.0752
Brugia malayi Cathepsin L-like precursor 0.0019 0.0345 0.0345
Schistosoma mansoni L-lactate dehydrogenase 0.007 0.3074 0.3074
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.4501 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0466 0.0396
Onchocerca volvulus 0.0056 0.2316 0.7028
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0073 0.0073
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0095 0.4349 0.9656
Brugia malayi Cathepsin L-like precursor 0.0056 0.2316 0.2316
Entamoeba histolytica cysteine proteinase 2 0.0029 0.0889 0.1213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.2316 0.5247
Brugia malayi AMP-binding enzyme family protein 0.0071 0.3099 0.3099
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0466 0.0888
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.2005 0.4362
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0126 0.5984 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.7301 0.7281
Echinococcus granulosus lamin dm0 0.0026 0.0752 0.0752
Plasmodium falciparum malate dehydrogenase 0.0126 0.5984 1
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.1395 0.1395
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.3986 0.8837
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0466 0.0396
Brugia malayi Thioredoxin reductase 0.0039 0.1395 0.1395
Schistosoma mansoni hypothetical protein 0.011 0.5127 0.5127
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0752 0.0752
Trypanosoma cruzi major cysteine proteinase, putative 0.0105 0.4899 0.4862
Trypanosoma cruzi cysteine peptidase, putative 0.0029 0.0889 0.0822
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.3986 0.8724
Schistosoma mansoni cathepsin F (C01 family) 0.0056 0.2316 0.2316
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0126 0.5984 0.5984
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0095 0.4349 1
Loa Loa (eye worm) hypothetical protein 0.011 0.5127 0.5127
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0095 0.4349 0.718
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.3986 0.8837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.7301 0.7281
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.1343 0.1343
Leishmania major cathepsin L-like protease 0.0056 0.2316 0.226
Trypanosoma cruzi cysteine protease, putative 0.0029 0.0889 0.0822
Loa Loa (eye worm) RecQ helicase 0.0029 0.0894 0.0894
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0095 0.4349 0.4308
Trichomonas vaginalis malate dehydrogenase, putative 0.0095 0.4349 1
Toxoplasma gondii lactate dehydrogenase LDH1 0.0126 0.5984 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.2316 0.5247
Plasmodium falciparum flap endonuclease 1 0.0026 0.0738 0.1233
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0466 0.092
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0466 0.092
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.0889 0.0889
Echinococcus granulosus malate dehydrogenase 0.0088 0.4001 0.4001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0889 0.1908
Echinococcus granulosus L lactate dehydrogenase B chain 0.0126 0.5984 0.5984
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0088 0.4001 0.4001
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0073 0.0073
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.2157 0.3525
Echinococcus granulosus bloom syndrome protein 0.0029 0.0894 0.0894
Onchocerca volvulus Cathepsin F homolog 0.0056 0.2316 0.7028
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0466 0.0396
Brugia malayi Cathepsin L-like precursor 0.0056 0.2316 0.2316
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.3099 0.3048
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0095 0.4349 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0727 0.0727
Echinococcus granulosus carbonic anhydrase 0.011 0.5127 0.5127
Toxoplasma gondii thioredoxin reductase 0.0039 0.1395 0.2331
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0071 0.3099 0.7077
Plasmodium falciparum L-lactate dehydrogenase 0.0126 0.5984 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.7034 0.7034
Entamoeba histolytica acyl-coA synthetase, putative 0.0071 0.3099 0.5025
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.2157 0.4706
Schistosoma mansoni malate dehydrogenase 0.0126 0.5984 0.5984
Entamoeba histolytica cysteine protease, putative 0.0029 0.0889 0.1213
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0111 0.0111
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0466 0.0396
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0466 0.092
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0073 0.0121
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0056 0.2316 0.2316
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.2005 0.4362
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.3099 0.7077
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.1422 0.1422
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.2316 0.5247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.2316 0.5247
Echinococcus granulosus flap endonuclease 1 0.0026 0.0738 0.0738
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.0889 0.0889
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.011 0.5127 0.5127
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0345 0.0345
Echinococcus multilocularis cysteine protease 0.0056 0.2316 0.2316
Brugia malayi AMP-binding enzyme family protein 0.0071 0.3099 0.3099
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0574 0.0574
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0095 0.4349 1
Mycobacterium ulcerans hypothetical protein 0.0071 0.3099 0.7077
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0466 0.0466
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0038 0.0038
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.4501 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.3099 0.3099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.7301 0.7281
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.2157 0.4873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.2316 0.5247
Brugia malayi cathepsin L-like precursor 0.0038 0.1343 0.1343
Trypanosoma cruzi cysteine peptidase, putative 0.0151 0.7301 0.7281
Brugia malayi Cathepsin L-like precursor 0.0038 0.1343 0.1343
Leishmania major cathepsin L-like protease 0.0056 0.2316 0.226
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.1422 0.1422
Trypanosoma cruzi cysteine peptidase, putative 0.0151 0.7301 0.7281
Echinococcus granulosus carbonic anhydrase 0.011 0.5127 0.5127
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0019 0.0345 0.0345
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0466 0.0779
Brugia malayi AMP-binding enzyme family protein 0.0071 0.3099 0.3099
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0071 0.3099 0.6833
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0185 0.0262
Schistosoma mansoni carbonic anhydrase-related 0.011 0.5127 0.5127
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0889 0.0889
Loa Loa (eye worm) malate dehydrogenase 0.0095 0.4349 0.4349
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.7301 0.7281
Echinococcus multilocularis carbonic anhydrase 0.011 0.5127 0.5127
Echinococcus multilocularis lamin 0.0026 0.0752 0.0752
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0466 0.092
Echinococcus multilocularis L lactate dehydrogenase 0.0055 0.2282 0.2282
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.3099 0.7077
Onchocerca volvulus 0.0056 0.2316 0.7028
Leishmania major cathepsin L-like protease 0.0151 0.7301 0.7281
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0073 0.0121
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.2316 0.5247
Leishmania major cathepsin L-like protease 0.0151 0.7301 0.7281
Mycobacterium ulcerans malate dehydrogenase 0.0095 0.4349 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.1343 0.297
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0095 0.4349 1
Loa Loa (eye worm) cysteine protease 0.0056 0.2316 0.2316
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0314 0.0545
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.011 0.5127 0.5127
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0738 0.0738
Trypanosoma cruzi cysteine proteinase, putative 0.0029 0.0889 0.0822
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0466 0.092
Loa Loa (eye worm) hypothetical protein 0.0053 0.2157 0.2157
Echinococcus multilocularis musashi 0.0026 0.0752 0.0752
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0738 0.067
Loa Loa (eye worm) hypothetical protein 0.0071 0.3099 0.3099
Onchocerca volvulus 0.0056 0.2316 0.7028
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0889 0.0889
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.0889 0.0822
Toxoplasma gondii lactate dehydrogenase LDH2 0.0126 0.5984 1
Schistosoma mansoni lamin 0.0026 0.0752 0.0752
Plasmodium vivax unspecified product 0.0019 0.0345 0.0461
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0202 1 1
Echinococcus granulosus cathepsin L 0.0029 0.0889 0.0889
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0088 0.4001 0.3957
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0738 0.0953
Loa Loa (eye worm) hypothetical protein 0.0019 0.0345 0.0345
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.3986 0.8837
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0466 0.0888
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.2316 0.5247
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0202 1 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0466 0.092
Schistosoma mansoni cathepsin s 0.0019 0.0345 0.0345
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0889 0.1213
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0056 0.2316 0.5247
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0738 0.067
Echinococcus granulosus carbonic anhydrase II 0.0202 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0466 0.092
Loa Loa (eye worm) hypothetical protein 0.0021 0.0466 0.0466
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0466 0.0888
Echinococcus multilocularis lactate dehydrogenase a 0.0126 0.5984 0.5984
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.1395 0.1332
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.3099 0.7077
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0466 0.092
Schistosoma mansoni malate dehydrogenase 0.0088 0.4001 0.4001
Entamoeba histolytica cysteine protease, putative 0.0029 0.0889 0.1213
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0738 0.1696
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0185 0.0113
Toxoplasma gondii hypothetical protein 0.011 0.5127 0.8568

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.0418 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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