TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 777.9 | Formula: C42H55N3O11
H donors: 5 H acceptors: 7 LogP: 5.95 Rotable bonds: 5
Rule of 5 violations (Lipinski): 2
SMILES: COC1/C=C/OC2(C)Oc3c(C2=O)c2cc(/C=N/N4CCCC4)c(c(c2c(c3C)O)O)NC(=O)/C(=C\C=C\C(C(C(C(C(C(C1C)OC(=O)C)C)O)C)O)C)/C
InChi: 1S/C42H55N3O11/c1-21-13-12-14-22(2)41(52)44-33-28(20-43-45-16-10-11-17-45)19-29-31(37(33)50)36(49)26(6)39-32(29)40(51)42(8,56-39)54-18-15-30(53-9)23(3)38(55-27(7)46)25(5)35(48)24(4)34(21)47/h12-15,18-21,23-25,30,34-35,38,47-50H,10-11,16-17H2,1-9H3,(H,44,52)/b13-12+,18-15+,22-14-,43-20+
InChiKey: LZFYQXMHVIOVHC-TVFAPQLQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Woolly monkey sarcoma virus	Simian sarcoma virus Pol protein	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	pol protein	Get druggable targets OG5_134588	All targets in OG5_134588
Echinococcus multilocularis	pol protein	Get druggable targets OG5_134588	All targets in OG5_134588
Trypanosoma congolense	Integrase core domain containing protein, putative	Get druggable targets OG5_134588	All targets in OG5_134588
Echinococcus multilocularis	pol protein	Get druggable targets OG5_134588	All targets in OG5_134588
Trypanosoma congolense	Integrase core domain containing protein, putative	Get druggable targets OG5_134588	All targets in OG5_134588
Echinococcus multilocularis	pol protein	Get druggable targets OG5_134588	All targets in OG5_134588
Trypanosoma congolense	RNase H/Integrase core domain containing protein, putative	Get druggable targets OG5_134588	All targets in OG5_134588

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	similar to Uncharacterized protein F44E2.2, putative	Simian sarcoma virus Pol protein	294 aa	269 aa	29.0 %
Schistosoma japonicum	similar to Uncharacterized protein F44E2.2, putative	Simian sarcoma virus Pol protein	294 aa	250 aa	27.2 %
Dictyostelium discoideum	hypothetical protein	Simian sarcoma virus Pol protein	294 aa	251 aa	25.1 %
Schistosoma japonicum	Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative	Simian sarcoma virus Pol protein	294 aa	292 aa	27.1 %
Schistosoma japonicum	similar to Uncharacterized protein F44E2.2, putative	Simian sarcoma virus Pol protein	294 aa	277 aa	28.9 %
Dictyostelium discoideum	hypothetical protein	Simian sarcoma virus Pol protein	294 aa	251 aa	25.1 %
Candida albicans	possible C-terminus	Simian sarcoma virus Pol protein	294 aa	254 aa	26.8 %
Schistosoma japonicum	similar to Uncharacterized protein F44E2.2, putative	Simian sarcoma virus Pol protein	294 aa	291 aa	26.1 %
Dictyostelium discoideum	hypothetical protein	Simian sarcoma virus Pol protein	294 aa	251 aa	25.1 %
Schistosoma japonicum	similar to Uncharacterized protein F44E2.2, putative	Simian sarcoma virus Pol protein	294 aa	268 aa	28.7 %
Schistosoma japonicum	similar to Uncharacterized protein F44E2.2, putative	Simian sarcoma virus Pol protein	294 aa	281 aa	27.0 %
Candida albicans	hypothetical protein	Simian sarcoma virus Pol protein	294 aa	254 aa	26.8 %
Schistosoma japonicum	similar to Uncharacterized protein F44E2.2, putative	Simian sarcoma virus Pol protein	294 aa	278 aa	27.7 %
Dictyostelium discoideum	hypothetical protein	Simian sarcoma virus Pol protein	294 aa	251 aa	25.1 %
Dictyostelium discoideum	hypothetical protein	Simian sarcoma virus Pol protein	294 aa	247 aa	23.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0007	0.011	0.0222
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0007	0.011	0.0222
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.1843	0.7888
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.1843	0.3712
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Toxoplasma gondii	UBA/TS-N domain-containing protein	0.0007	0.011	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0.011	0.0222
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0007	0.011	0.0222
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0007	0.011	0.0222
Echinococcus granulosus	ubiquitin specific peptidase c family	0.0007	0.011	0.0473
Plasmodium vivax	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Harbinger-1_Harbinger/PIFA2 transposable element protein	0.0007	0.011	0.5
Trypanosoma cruzi	Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Echinococcus multilocularis	expressed protein	0.0007	0.011	0.011
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Brugia malayi	MH2 domain containing protein	0.0009	0.0193	0.0389
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.046	0.1969
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Plasmodium falciparum	ubiquitin carboxyl-terminal hydrolase 13, putative	0.0007	0.011	0.5
Echinococcus multilocularis	GPCR, family 2	0.0016	0.046	0.046
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 14	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 24 (C19 family)	0.0007	0.011	0.0473
Echinococcus multilocularis	ubiquitin specific peptidase 42 (C19 family)	0.0007	0.011	0.011
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0007	0.011	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.0131	0.4965	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Brugia malayi	MH1 domain containing protein	0.0005	0.0037	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0007	0.011	0.0222
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0007	0.011	0.011
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0007	0.011	0.5
Echinococcus granulosus	u4:u6.u5 tri snrnp associated protein 2	0.0007	0.011	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0007	0.011	0.0222
Leishmania major	ubiqitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Plasmodium vivax	ubiquitin carboxyl-terminal hydrolase 13, putative	0.0007	0.011	0.5
Entamoeba histolytica	hypothetical protein	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.2337	0.4706
Echinococcus granulosus	5'partial\|Ubiquitin carboxyl terminal hydrolase 48	0.0007	0.011	0.0473
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0007	0.011	0.0222
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Plasmodium falciparum	ubiquitin specific protease, putative	0.0007	0.011	0.5
Echinococcus granulosus	Smad4	0.0009	0.0193	0.0826
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase	0.0007	0.011	0.011
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Toxoplasma gondii	hypothetical protein	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Brugia malayi	MH1 domain containing protein	0.0009	0.0193	0.0389
Trypanosoma brucei	Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0007	0.011	0.0222
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0007	0.011	0.0473
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trypanosoma brucei	Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0007	0.011	0.5
Trichomonas vaginalis	Harbinger-1_Harbinger/PIFA2 transposable element protein	0.0007	0.011	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0007	0.011	0.5
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0007	0.011	0.0473
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0007	0.011	0.5
Giardia lamblia	Hypothetical protein	0.0007	0.011	0.5
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0193	0.0826
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0007	0.011	0.0222
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Echinococcus granulosus	Ubiquitin carboxyl terminal hydrolase 48	0.0007	0.011	0.0473
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.2337	1
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0007	0.011	0.5
Trichomonas vaginalis	ubiquitin specific protease, putative	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 46 (C19 family)	0.0007	0.011	0.0473
Schistosoma mansoni	ubiquitin-specific peptidase 9X (C19 family)	0.0007	0.011	0.0473
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Plasmodium falciparum	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Onchocerca volvulus		0.0007	0.011	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1843	0.7888
Trypanosoma brucei	cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Loa Loa (eye worm)	transcription factor SMAD2	0.0131	0.4965	1
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0193	0.0193
Plasmodium falciparum	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Toxoplasma gondii	ubiquitin-specific protease USP4	0.0007	0.011	0.5
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Toxoplasma gondii	ubiquitin specific protease 39 isoform 2, putative	0.0007	0.011	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 16 (C19 family)	0.0007	0.011	0.0473
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 14	0.0007	0.011	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.2337	1
Schistosoma mansoni	hypothetical protein	0.0016	0.046	0.1969
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 20	0.0007	0.011	0.0473
Echinococcus granulosus	tar DNA binding protein	0.0064	0.2337	1
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0007	0.011	0.0222
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Echinococcus multilocularis	Smad4	0.0009	0.0193	0.0193
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1843	0.7888
Brugia malayi	ubiquitin carboxyl-terminal hydrolase 46	0.0007	0.011	0.0222
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0007	0.011	0.0222
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0007	0.011	0.0222
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase 46	0.0007	0.011	0.0222
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 20	0.0007	0.011	0.011
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Echinococcus granulosus	ubiquitin specific protease 41	0.0007	0.011	0.0473
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0007	0.011	0.5
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.046	0.0927
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0007	0.011	0.011
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 5	0.0007	0.011	0.0473
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0193	0.0389
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0007	0.011	0.0222
Schistosoma mansoni	calpain-7 (C02 family)	0.0007	0.011	0.0473
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0.011	0.0222
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 7	0.0007	0.011	0.0473
Loa Loa (eye worm)	Smad1	0.0009	0.0193	0.0389
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 16	0.0007	0.011	0.0473
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.2337	1
Echinococcus multilocularis	u4:u6.u5 tri snrnp associated protein 2	0.0007	0.011	0.011
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0007	0.011	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1175	0.2367
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0007	0.011	0.0222
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.1791	0.3608
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0007	0.011	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 5 (C19 family)	0.0007	0.011	0.0473
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0007	0.011	0.5
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Plasmodium vivax	U4/U6.U5 tri-snRNP-associated protein 2, putative	0.0007	0.011	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0007	0.011	0.5
Plasmodium falciparum	U4/U6.U5 tri-snRNP-associated protein 2, putative	0.0007	0.011	0.5
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0193	0.0826
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0007	0.011	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0007	0.011	0.0473
Schistosoma mansoni	hypothetical protein	0.0016	0.046	0.1969
Plasmodium vivax	ubiquitin carboxyl-terminal hydrolase 1, putative	0.0007	0.011	0.5
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Onchocerca volvulus		0.0007	0.011	1
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 4 (C19 family)	0.0007	0.011	0.0473
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.2337	0.4706
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 4	0.0007	0.011	0.011
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0007	0.011	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0037	0.0075
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0007	0.011	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0007	0.011	0.0222
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Brugia malayi	TAR-binding protein	0.0064	0.2337	0.4706
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 9X (C19 family)	0.0007	0.011	0.0473
Echinococcus multilocularis	pol protein	0.0259	1	1
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase family 2 protein	0.0007	0.011	0.5
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.1791	0.3608
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0007	0.011	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 14 (C19 family)	0.0007	0.011	0.0473
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0193	0.0826
Schistosoma mansoni	ubiquitin-specific peptidase 45 (C19 family)	0.0007	0.011	0.0473
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0007	0.011	0.5
Loa Loa (eye worm)	ubiquitin specific peptidase 39	0.0007	0.011	0.0222
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0007	0.011	0.5
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.1175	0.2367
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 23	0.0007	0.011	0.0473
Schistosoma mansoni	ubiquitin-specific peptidase 30 (C19 family)	0.0007	0.011	0.0473
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0007	0.011	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0193	0.0826
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0193	0.0389
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Brugia malayi	ubiquitin specific protease 14	0.0007	0.011	0.0222
Giardia lamblia	DUB-1	0.0007	0.011	0.5
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 36	0.0007	0.011	0.0473
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0007	0.011	0.0222
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Brugia malayi	MH2 domain containing protein	0.0009	0.0193	0.0389
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0007	0.011	0.0222
Schistosoma mansoni	ubiquitin-specific peptidase 7 (C19 family)	0.0007	0.011	0.0473
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 4	0.0007	0.011	0.0473
Trichomonas vaginalis	Harbinger-1_Harbinger/PIFA2 transposable element protein	0.0007	0.011	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0007	0.011	0.0222
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0007	0.011	0.0222
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Schistosoma mansoni	peptidase	0.0007	0.011	0.0473
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 24	0.0007	0.011	0.0473
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.1843	0.3712
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0007	0.011	0.0222
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Echinococcus granulosus	ubiquitin specific peptidase 30 (C19 family)	0.0007	0.011	0.0473
Echinococcus multilocularis	ubiquitin specific protease 41	0.0007	0.011	0.011
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 47	0.0007	0.011	0.011
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0007	0.011	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0.011	0.0222
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 14	0.0007	0.011	0.011
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 47	0.0007	0.011	0.0473
Trichomonas vaginalis	ubiquitin specific protease, putative	0.0007	0.011	0.5
Brugia malayi	MH1 domain containing protein	0.0005	0.0037	0.0075
Echinococcus multilocularis	Ubiquitin carboxyl terminal hydrolase 48	0.0007	0.011	0.011
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.046	0.0927
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 14	0.0007	0.011	0.0473
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0007	0.011	0.5
Trichomonas vaginalis	Harbinger-1_Harbinger/PIFA2 transposable element protein	0.0007	0.011	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase 5, putative	0.0007	0.011	0.5
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0007	0.011	0.5
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 7	0.0007	0.011	0.011
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0193	0.0826
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Brugia malayi	MH1 domain containing protein	0.0009	0.0193	0.0389
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Schistosoma mansoni	ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold	0.0007	0.011	0.0473
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 7	0.0007	0.011	0.0473
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0.011	0.0222
Echinococcus multilocularis	ubiquitin specific peptidase (c family) ubiquitin terminal hydrolase	0.0007	0.011	0.011
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0.011	0.0222
Schistosoma mansoni	smad	0.0009	0.0193	0.0826
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase 5, putative	0.0007	0.011	0.5
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 36	0.0007	0.011	0.011
Schistosoma mansoni	Smad4	0.0009	0.0193	0.0826
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0007	0.011	0.0222
Loa Loa (eye worm)	RNA binding protein	0.0064	0.2337	0.4706
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 24	0.0007	0.011	0.011
Schistosoma mansoni	ubiquitin-specific peptidase 48 (C19 family)	0.0007	0.011	0.0473
Schistosoma mansoni	hypothetical protein	0.0016	0.046	0.1969
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.2337	0.2337
Plasmodium vivax	ubiquitin specific protease, putative	0.0007	0.011	0.5
Echinococcus granulosus	GPCR family 2	0.0016	0.046	0.1969
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0007	0.011	0.0222
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 16	0.0007	0.011	0.011
Schistosoma mansoni	ubiquitin-specific peptidase 22 (C19 family)	0.0007	0.011	0.0473
Trypanosoma cruzi	Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Loa Loa (eye worm)	nuclear factor I	0.0005	0.0037	0.0075
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.2337	0.4706
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0007	0.011	0.5
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 22	0.0007	0.011	0.011
Echinococcus multilocularis	pol protein	0.0259	1	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.011	0.0222
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0007	0.011	0.5
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0007	0.011	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.1791	0.3608
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0193	0.0826
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0007	0.011	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0.011	0.0222
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0007	0.011	0.0222
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0007	0.011	0.0222
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.046	0.1969
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 7	0.0007	0.011	0.011
Trichomonas vaginalis	ubiquitin specific protease, putative	0.0007	0.011	0.5
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 12	0.0007	0.011	0.0473
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.2337	1
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 42 (C19 family)	0.0007	0.011	0.0473
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.046	0.046
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Echinococcus granulosus	smad	0.0009	0.0193	0.0826
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Schistosoma mansoni	hypothetical protein	0.0034	0.1175	0.503
Schistosoma mansoni	ubiquitin-specific peptidase 44 (C19 family)	0.0007	0.011	0.0473
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0007	0.011	0.5
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0007	0.011	0.5
Plasmodium vivax	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 4	0.0007	0.011	0.011
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Onchocerca volvulus		0.0007	0.011	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Schistosoma mansoni	calpain-7 (C02 family)	0.0007	0.011	0.0473
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 4	0.0007	0.011	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0016	0.046	0.0927
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0007	0.011	0.0222
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0007	0.011	0.0473
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.046	0.0927
Echinococcus multilocularis	pol protein	0.0259	1	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Brugia malayi	Smad1	0.0009	0.0193	0.0389
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0007	0.011	0.5
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 4	0.0007	0.011	0.0473
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 5	0.0007	0.011	0.011
Plasmodium falciparum	ubiquitin specific protease, putative	0.0007	0.011	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 10 (C19 family)	0.0007	0.011	0.0473
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Brugia malayi	MH2 domain containing protein	0.0131	0.4965	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0007	0.011	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0007	0.011	0.5
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 22	0.0007	0.011	0.0473
Echinococcus multilocularis	smad	0.0009	0.0193	0.0193
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Brugia malayi	hypothetical protein	0.0007	0.011	0.0222
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0007	0.011	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.2337	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0007	0.011	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1843	0.7888
Loa Loa (eye worm)	hypothetical protein	0.0007	0.011	0.0222
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0007	0.011	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.1791	0.3608
Schistosoma mansoni	hypothetical protein	0.0007	0.011	0.0473
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0193	0.0193
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.1843	0.1843
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 4	0.0007	0.011	0.011
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Brugia malayi	RNA binding protein	0.0064	0.2337	0.4706
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0007	0.011	0.5
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Plasmodium vivax	ubiquitin carboxyl-terminal hydrolase 2, putative	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Schistosoma mansoni	family C19 unassigned peptidase (C19 family)	0.0007	0.011	0.0473
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0007	0.011	0.5
Plasmodium falciparum	ubiquitin carboxyl-terminal hydrolase 2, putative	0.0007	0.011	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.1843	0.1843
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0007	0.011	0.5
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.1843	0.7888
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Schistosoma mansoni	family C19 non-peptidase homologue (C19 family)	0.0007	0.011	0.0473
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.046	0.046
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Schistosoma mansoni	hypothetical protein	0.0016	0.046	0.1969
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0007	0.011	0.0222
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase	0.0007	0.011	0.0473
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0007	0.011	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0.011	0.0222
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 12	0.0007	0.011	0.011
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0007	0.011	0.5
Plasmodium falciparum	ubiquitin carboxyl-terminal hydrolase 14	0.0007	0.011	0.5
Plasmodium vivax	ubiquitin carboxyl-terminal hydrolase family 2, putative	0.0007	0.011	0.5
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0007	0.011	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0007	0.011	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.011	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0.011	0.0222

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.000017 M l-1	Ability to inhibit simian sarcoma virus reverse transcriptase	ChEMBL.	6154141
IC50 (binding)	= 0.000017 M l-1	Ability to inhibit simian sarcoma virus reverse transcriptase	ChEMBL.	6154141
IC50 (binding)	= 0.00024 M l-1	Ability to inhibit mouse alpha DNA polymerase	ChEMBL.	6154141
IC50 (binding)	= 0.00024 M l-1	Ability to inhibit mouse beta DNA polymerase	ChEMBL.	6154141
IC50 (binding)	= 0.00024 M l-1	Ability to inhibit mouse beta DNA polymerase	ChEMBL.	6154141
Log 1/C (binding)	= 4.77	Inhibition of simian sarcoma virus reverse transcriptase	ChEMBL.	6154141
Log 1/C (binding)	= 3.62	The logarithm of the reciprocal of the concentration which produces 50% inhibition of mammalian alpha DNA polymerase.	ChEMBL.	6154141
Log 1/C (binding)	= 3.62	The logarithm of the reciprocal of the concentration which produces 50% inhibition of mammalian beta DNA polymerase.	ChEMBL.	6154141
Log 1/C (binding)	= 4.77	Inhibition of simian sarcoma virus reverse transcriptase	ChEMBL.	6154141
logP (ADMET)	= 2.75	Partition coefficient (logP)	ChEMBL.	6154141

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL89467

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 145889