Detailed information for compound 1461635

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 386.438 | Formula: C22H26O6
  • H donors: 0 H acceptors: 3 LogP: 4.13 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c2c1C(=O)C(=CC2=O)[C@H](OC(=O)C(C)C)CC=C(C)C)OC
  • InChi: 1S/C22H26O6/c1-12(2)7-8-16(28-22(25)13(3)4)14-11-15(23)19-17(26-5)9-10-18(27-6)20(19)21(14)24/h7,9-11,13,16H,8H2,1-6H3/t16-/m1/s1
  • InChiKey: PUZWAWSBUHTJLQ-MRXNPFEDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1434 0.0841 0.9032
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.0025 0.0258
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0508 0.0277 0.3523
Trichomonas vaginalis conserved hypothetical protein 0.0464 0.0249 0.3094
Entamoeba histolytica cysteine proteinase, putative 0.0183 0.0078 0.0705
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0311 0.0157 0.1677
Trypanosoma cruzi cysteine peptidase, putative 0.0357 0.0185 0.0532
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1581 0.0931 0.2686
Schistosoma mansoni hypothetical protein 0.0544 0.0298 0.3177
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0095 0.0025 0.0258
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0083 0.0017 0.0145
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0544 0.0298 0.0286
Loa Loa (eye worm) phosphatidylinositol 3 0.1302 0.0761 0.8173
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0735 0.0415 0.4453
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0271 0.0132 0.138
Echinococcus multilocularis Zinc finger, PHD finger 0.0376 0.0196 0.0184
Loa Loa (eye worm) hypothetical protein 0.0095 0.0025 0.0258
Schistosoma mansoni hypothetical protein 0.0412 0.0218 0.2306
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1321 0.0773 0.9853
Echinococcus multilocularis serine protein kinase ATM 0.0765 0.0433 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.134 0.0784 1
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0025 0.019
Brugia malayi cathepsin Z-like cysteine proteinase 0.0095 0.0025 0.0258
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0271 0.0132 0.0379
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.0747 0.9516
Loa Loa (eye worm) hypothetical protein 0.0224 0.0103 0.1102
Onchocerca volvulus 0.0311 0.0157 1
Entamoeba histolytica cysteine protease, putative 0.0183 0.0078 0.0705
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1382 0.081 0.2336
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0815 0.0464 0.6026
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0508 0.0277 0.0797
Loa Loa (eye worm) hypothetical protein 0.0224 0.0103 0.1102
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0271 0.0132 0.1678
Leishmania major phosphatidylinositol kinase related protein, putative 0.0301 0.015 0.0413
Loa Loa (eye worm) hypothetical protein 0.0088 0.002 0.0211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0311 0.0157 0.1895
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0271 0.0132 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.1298 0.0758 0.9665
Echinococcus granulosus cathepsin L cysteine protease 0.0183 0.0078 0.0065
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.0025 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.134 0.0784 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0271 0.0132 0.1577
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0311 0.0157 0.1677
Entamoeba histolytica protein kinase rad3, putative 0.0735 0.0415 0.5138
Trichomonas vaginalis PIKK family atypical protein kinase 0.1297 0.0758 0.9664
Echinococcus granulosus serine protein kinase ATM 0.0765 0.0433 0.0421
Brugia malayi Cathepsin L-like precursor 0.0311 0.0157 0.1677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0772 0.0438 0.5527
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.0747 0.9516
Onchocerca volvulus 0.0271 0.0132 0.8137
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0095 0.0025 0.019
Mycobacterium tuberculosis Conserved hypothetical protein 0.0271 0.0132 0.5
Schistosoma mansoni cathepsin S (C01 family) 0.0095 0.0025 0.0221
Entamoeba histolytica hypothetical protein 0.0271 0.0132 0.1414
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0183 0.0078 0.0799
Loa Loa (eye worm) cytochrome P450 family protein 0.0117 0.0038 0.0405
Trypanosoma cruzi cysteine proteinase, putative 0.0183 0.0078 0.0224
Entamoeba histolytica cysteine protease, putative 0.0183 0.0078 0.0705
Loa Loa (eye worm) hypothetical protein 0.0271 0.0132 0.1413
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0554 0.0305 0.0879
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0025 0.019
Entamoeba histolytica cysteine proteinase, putative 0.0183 0.0078 0.0705
Schistosoma mansoni hypothetical protein 0.0271 0.0132 0.138
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0311 0.0157 0.1895
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0183 0.0078 0.0799
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0076 0.0013 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.1297 0.0758 0.9664
Onchocerca volvulus 0.0311 0.0157 1
Brugia malayi Cathepsin L-like precursor 0.0311 0.0157 0.1677
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0088 0.002 0.0211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0311 0.0157 0.1895
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0376 0.0196 0.2104
Echinococcus multilocularis microtubule associated protein 2 0.0694 0.039 0.0378
Leishmania major cathepsin L-like protease 0.0311 0.0157 0.043
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1079 0.0625 0.7942
Brugia malayi Papain family cysteine protease containing protein 0.0311 0.0157 0.1677
Trichomonas vaginalis PIKK family atypical protein kinase 0.1316 0.077 0.9813
Onchocerca volvulus Cathepsin F homolog 0.0311 0.0157 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.0025 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.1301 0.076 0.969
Trypanosoma cruzi cysteine peptidase, putative 0.0357 0.0185 0.0532
Trichomonas vaginalis PIKK family atypical protein kinase 0.1316 0.077 0.9813
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1079 0.0625 0.1802
Giardia lamblia Hypothetical protein 0.0271 0.0132 0.1414
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1581 0.0931 1
Brugia malayi Cathepsin L-like precursor 0.0088 0.002 0.0211
Entamoeba histolytica cysteine protease, putative 0.0183 0.0078 0.0705
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1079 0.0625 0.7942
Loa Loa (eye worm) cysteine protease 0.0311 0.0157 0.1677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0777 0.0441 0.5565
Entamoeba histolytica cysteine proteinase, putative 0.0183 0.0078 0.0705
Trypanosoma cruzi cysteine peptidase, putative 0.0183 0.0078 0.0224
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0271 0.0132 0.1714
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0376 0.0196 0.2408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0271 0.0132 0.1577
Schistosoma mansoni cathepsin F (C01 family) 0.0311 0.0157 0.1646
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0757 0.0428 0.5315
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0578 0.0319 0.3882
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0025 0.019
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0355 0.0183 0.1962
Trypanosoma cruzi cysteine peptidase, putative 0.0311 0.0157 0.045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.0025 0.019
Onchocerca volvulus 0.0311 0.0157 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0376 0.0196 0.2104
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0095 0.0025 0.0258
Loa Loa (eye worm) apoptosis regulator protein 0.0083 0.0017 0.0182
Schistosoma mansoni cathepsin F (C01 family) 0.0224 0.0103 0.1068
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1434 0.0841 0.0829
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0311 0.0157 0.1895
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0271 0.0132 0.0119
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0311 0.0157 0.1895
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.134 0.0784 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0947 0.0544 0.6845
Trichomonas vaginalis PIKK family atypical protein kinase 0.1321 0.0773 0.9851
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0765 0.0433 0.465
Echinococcus granulosus cathepsin L cysteine proteinase 0.0311 0.0157 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.1321 0.0773 0.9851
Onchocerca volvulus Cathepsin L homolog 0.0311 0.0157 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0735 0.0415 0.1196
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0765 0.0433 0.463
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0554 0.0305 0.381
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.134 0.0784 1
Plasmodium vivax vivapain-2 0.0311 0.0157 0.7746
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0376 0.0196 0.2498
Loa Loa (eye worm) phosphatidylinositol 3 0.0271 0.0132 0.1413
Brugia malayi Cathepsin L-like cysteine proteinase 0.0224 0.0103 0.1102
Echinococcus granulosus cathepsin L 0.0183 0.0078 0.0065
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0745 0.0421 0.5224
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.134 0.0784 1
Entamoeba histolytica cysteine protease, putative 0.0183 0.0078 0.0705
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0808 0.0459 0.5725
Brugia malayi Papain family cysteine protease containing protein 0.0183 0.0078 0.0834
Trichomonas vaginalis PIKK family atypical protein kinase 0.0772 0.0438 0.5527
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.0249 0.3094
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0271 0.0132 0.1714
Entamoeba histolytica cysteine protease, putative 0.0183 0.0078 0.0705
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0095 0.0025 0.0249
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1581 0.0931 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0311 0.0157 0.1895
Echinococcus granulosus cathepsin l1 0.0224 0.0103 0.009
Plasmodium vivax vivapain-1 0.0183 0.0078 0.3288
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0271 0.0132 0.1413
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0095 0.0025 0.0249
Onchocerca volvulus 0.0271 0.0132 0.8137
Echinococcus multilocularis cathepsin b 0.1581 0.0931 0.0919
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0376 0.0196 0.255
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0311 0.0157 0.0144
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0095 0.0025 0.0249
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.071 0.04 0.0387
Onchocerca volvulus 0.0224 0.0103 0.5946
Plasmodium vivax serine-repeat antigen (SERA) 0.0095 0.0025 0.0249
Schistosoma mansoni microtubule-associated protein tau 0.0694 0.039 0.4167
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.0218 0.0205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183 0.0078 0.099
Leishmania major cysteine peptidase A (CPA) 0.0311 0.0157 0.043
Brugia malayi fibroinase precursor 0.0095 0.0025 0.0258
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.0025 0.019
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.134 0.0784 0.0772
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0877 0.0502 0.6352
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0095 0.0025 0.0221
Onchocerca volvulus 0.0311 0.0157 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0224 0.0103 0.1204
Onchocerca volvulus 0.0311 0.0157 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.0025 0.019
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1382 0.081 0.0798
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0311 0.0157 0.1895
Trypanosoma cruzi cysteine peptidase, putative 0.0357 0.0185 0.0532
Leishmania major phosphatidylinositol 4-kinase, putative 0.0271 0.0132 0.0362
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0376 0.0196 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0056 0 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.134 0.0784 0.8422
Entamoeba histolytica cysteine protease, putative 0.0183 0.0078 0.0705
Trichomonas vaginalis PIKK family atypical protein kinase 0.1321 0.0773 0.9851
Plasmodium vivax serine-repeat antigen (SERA) 0.0095 0.0025 0.0249
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0271 0.0132 0.6349
Loa Loa (eye worm) hypothetical protein 0.1581 0.0931 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0554 0.0305 0.3246
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0376 0.0196 0.0184
Giardia lamblia Cathepsin B precursor 0.0554 0.0305 0.369
Trichomonas vaginalis PIKK family atypical protein kinase 0.1316 0.077 0.9813
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0834 0.0475 0.606
Plasmodium vivax hypothetical protein 0.0271 0.0132 0.6349
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.0025 0.019
Leishmania major phosphatidylinositol 3-kinase, putative 0.1279 0.0747 0.2056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0224 0.0103 0.1204
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0376 0.0196 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.002 0.0211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0772 0.0438 0.5527
Brugia malayi cathepsin F-like cysteine proteinase 0.0088 0.002 0.0211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.0078 0.0881
Toxoplasma gondii cathepsin CPC2 0.0095 0.0025 0.0318
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1382 0.081 0.8698
Schistosoma mansoni hypothetical protein 0.0083 0.0017 0.0145
Plasmodium falciparum cysteine proteinase falcipain 3 0.0311 0.0157 0.7688
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0311 0.0157 0.1895
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0271 0.0132 0.138
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0508 0.0277 0.3445
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1301 0.076 0.9694
Brugia malayi Cathepsin L-like precursor 0.0311 0.0157 0.1677
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0376 0.0196 0.2261
Trichomonas vaginalis PIKK family atypical protein kinase 0.1316 0.077 0.9813
Trypanosoma cruzi cruzipain precursor, putative 0.0088 0.002 0.0057
Leishmania major hypothetical protein, conserved 0.6006 0.363 1
Echinococcus multilocularis 0.0271 0.0132 0.0119
Echinococcus multilocularis cysteine protease 0.0311 0.0157 0.0144
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0508 0.0277 0.2967
Trypanosoma cruzi major cysteine proteinase, putative 0.0141 0.0053 0.0151
Trypanosoma brucei cysteine peptidase C (CPC) 0.0554 0.0305 0.3884
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0025 0.019
Echinococcus granulosus cathepsin b 0.1581 0.0931 0.0919
Loa Loa (eye worm) phosphatidylinositol 3 0.1301 0.076 0.8164
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0311 0.0157 0.1895
Loa Loa (eye worm) phosphatidylinositol 3 0.0271 0.0132 0.1413
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0554 0.0305 0.0838
Entamoeba histolytica hypothetical protein 0.0765 0.0433 0.538
Echinococcus multilocularis cathepsin L 0.0095 0.0025 0.0012
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0271 0.0132 0.1414
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0311 0.0157 0.1895
Brugia malayi cathepsin Z-like cysteine proteinase 0.0095 0.0025 0.0258
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.0025 0.019
Plasmodium vivax hypothetical protein, conserved 0.0271 0.0132 0.6349
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0376 0.0196 0.0539
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0083 0.0017 0.0005
Entamoeba histolytica cysteine protease, putative 0.0183 0.0078 0.0705
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0271 0.0132 0.0119
Entamoeba histolytica hypothetical protein 0.0271 0.0132 0.1414
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0095 0.0025 0.0249
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0271 0.0132 0.0379
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0311 0.0157 0.1895
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.0025 0.019
Entamoeba histolytica cysteine protease, putative 0.0183 0.0078 0.0705
Trichomonas vaginalis PIKK family atypical protein kinase 0.0765 0.0433 0.5467
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0095 0.0025 0.019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0311 0.0157 0.1895
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0357 0.0185 0.2351
Entamoeba histolytica cysteine protease, putative 0.0183 0.0078 0.0705
Brugia malayi cathepsin F-like cysteine proteinase 0.0095 0.0025 0.0258
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0271 0.0132 0.0119
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0271 0.0132 0.6256
Echinococcus granulosus cathepsin L 0.0095 0.0025 0.0012
Entamoeba histolytica hypothetical protein 0.0271 0.0132 0.1414
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0311 0.0157 0.1895
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0508 0.0277 0.3445
Loa Loa (eye worm) phosphatidylinositol kinase 0.0271 0.0132 0.1413
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0017 0.0142
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0095 0.0025 0.0249
Leishmania major cathepsin L-like protease 0.0357 0.0185 0.0507
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1079 0.0625 0.7902
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0357 0.0185 0.2351
Loa Loa (eye worm) hypothetical protein 0.0095 0.0025 0.0258
Loa Loa (eye worm) phosphatidylinositol 3 0.0271 0.0132 0.1413
Trichomonas vaginalis PIKK family atypical protein kinase 0.1298 0.0758 0.9665
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0357 0.0185 0.2351
Plasmodium vivax unspecified product 0.0095 0.0025 0.0249
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0301 0.015 0.0432
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0095 0.0025 0.0249
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0765 0.0433 0.1249
Plasmodium vivax vivapain-3 0.0183 0.0078 0.3288
Loa Loa (eye worm) phosphatidylinositol 3 0.0237 0.0111 0.119
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0095 0.0025 0.0258
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1581 0.0931 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0376 0.0196 0.0565
Mycobacterium leprae conserved hypothetical protein 0.0271 0.0132 0.5
Schistosoma mansoni cathepsin B (C01 family) 0.0095 0.0025 0.0221
Toxoplasma gondii cathepsin CPL 0.0311 0.0157 0.2034
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0083 0.0017 0.0005
Plasmodium falciparum cysteine proteinase falcipain 1 0.0183 0.0078 0.3117
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0025 0.0221
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0311 0.0157 0.1895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0735 0.0415 0.523
Plasmodium vivax vivapain-2 0.0311 0.0157 0.7746
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0544 0.0298 0.0286
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1321 0.0773 0.2127
Loa Loa (eye worm) hypothetical protein 0.0095 0.0025 0.0258
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1382 0.081 0.0798
Schistosoma mansoni cathepsin C 0.0095 0.0025 0.0221
Entamoeba histolytica cysteine proteinase, putative 0.0224 0.0103 0.1034
Loa Loa (eye worm) cathepsin B 0.0554 0.0305 0.3271
Echinococcus granulosus cathepsin b 0.1581 0.0931 0.0919
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0376 0.0196 0.0565
Trichomonas vaginalis conserved hypothetical protein 0.0544 0.0298 0.3728
Leishmania major phosphatidylinositol 3-kinase, putative 0.0376 0.0196 0.0539
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1279 0.0747 0.9522
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0403 0.0212 0.2471
Trypanosoma cruzi target of rapamycin kinase 3 0.1321 0.0773 0.2229
Toxoplasma gondii cathepsin B 0.0554 0.0305 0.3961
Trichomonas vaginalis PIKK family atypical protein kinase 0.1302 0.0761 0.9703
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0311 0.0157 0.1895
Loa Loa (eye worm) phosphatidylinositol 3 0.0271 0.0132 0.1413
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0357 0.0185 0.2351
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1079 0.0625 0.7942
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0508 0.0277 0.3318
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0183 0.0078 0.0799
Loa Loa (eye worm) hypothetical protein 0.0088 0.002 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0357 0.0185 0.2351
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1301 0.076 0.2093
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0083 0.0017 0.0182
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0311 0.0157 0.0144
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0271 0.0132 0.1678
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0271 0.0132 0.0379
Loa Loa (eye worm) phosphatidylinositol 3 0.134 0.0784 0.8422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0311 0.0157 0.1895
Loa Loa (eye worm) hypothetical protein 0.0494 0.0268 0.2873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0311 0.0157 0.1895
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0376 0.0196 0.2261
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0095 0.0025 0.019
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0311 0.0157 0.7688
Brugia malayi cathepsin B-like cysteine proteinase 0.1581 0.0931 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1316 0.077 0.9813
Trypanosoma cruzi cysteine peptidase, putative 0.0088 0.002 0.0057
Echinococcus granulosus microtubule associated protein 2 0.0694 0.039 0.0378
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0095 0.0025 0.0221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0311 0.0157 0.1895
Loa Loa (eye worm) hypothetical protein 0.0083 0.0017 0.0182
Brugia malayi cathepsin L precursor 0.0095 0.0025 0.0258
Entamoeba histolytica cysteine protease, putative 0.0183 0.0078 0.0705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.0078 0.0881
Trypanosoma cruzi hypothetical protein, conserved 0.5735 0.3465 1
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.0025 0.0258
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0095 0.0025 0.0258
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0311 0.0157 0.1895
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0025 0.019
Loa Loa (eye worm) ctsf protein 0.0311 0.0157 0.1677
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0025 0.0221
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0271 0.0132 0.138
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.6447 1 1
Leishmania major cathepsin L-like protease 0.0311 0.0157 0.043
Echinococcus multilocularis cysteine protease 0.0311 0.0157 0.0144
Schistosoma mansoni fkbp-rapamycin associated protein 0.0735 0.0415 0.4432
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0271 0.0132 0.1714
Echinococcus granulosus cysteine protease 0.0183 0.0078 0.0065
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0076 0.0013 0.0133
Giardia lamblia Cathepsin B precursor 0.0554 0.0305 0.369
Giardia lamblia Cathepsin B precursor 0.0554 0.0305 0.369
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1434 0.0841 0.0829
Trypanosoma cruzi cysteine protease, putative 0.0183 0.0078 0.0224
Toxoplasma gondii cathepsin CPC1 0.0095 0.0025 0.0318
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0025 0.0221
Loa Loa (eye worm) hypothetical protein 0.0095 0.0025 0.0258
Leishmania major cathepsin L-like protease 0.0311 0.0157 0.043
Trichomonas vaginalis PIKK family atypical protein kinase 0.1316 0.077 0.9813
Brugia malayi Cathepsin L-like precursor 0.0224 0.0103 0.1102
Giardia lamblia GTOR 0.134 0.0784 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0007 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.1298 0.0758 0.9665
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.134 0.0784 0.8416
Echinococcus granulosus dnaJ subfamily B 0.0412 0.0218 0.0205
Loa Loa (eye worm) hypothetical protein 0.0095 0.0025 0.0258
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0311 0.0157 0.1895
Trichomonas vaginalis PIKK family atypical protein kinase 0.1316 0.077 0.9813
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.071 0.04 0.0387
Toxoplasma gondii target of rapamycin (TOR), putative 0.1316 0.077 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0311 0.0157 0.1895
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0508 0.0277 0.3318
Echinococcus multilocularis cathepsin L cysteine protease 0.0311 0.0157 0.0144
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0877 0.0502 0.6352
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0376 0.0196 0.2408
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1382 0.081 0.2336
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1079 0.0625 0.1802
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0376 0.0196 0.2074
Brugia malayi FAT domain containing protein 0.0544 0.0298 0.3203
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0735 0.0415 0.0402
Onchocerca volvulus Cathepsin L homolog 0.0311 0.0157 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0311 0.0157 0.0144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0357 0.0185 0.2351
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.0025 0.019
Leishmania major hypothetical protein, unknown function 0.0271 0.0132 0.0362
Echinococcus granulosus cathepsin l1 0.0311 0.0157 0.0144
Leishmania major cathepsin L-like protease 0.0357 0.0185 0.0507
Entamoeba histolytica cysteine proteinase, putative 0.0311 0.0157 0.1738
Trypanosoma cruzi cysteine proteinase, putative 0.0183 0.0078 0.0224
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1382 0.081 0.8693
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.027 0.0131 0.0377
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0508 0.0277 0.2941
Loa Loa (eye worm) fibroinase 0.0311 0.0157 0.1677
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0357 0.0185 0.2351
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0376 0.0196 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0757 0.0428 0.5404
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.0747 0.9516
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0271 0.0132 0.1413
Trichomonas vaginalis PIKK family atypical protein kinase 0.029 0.0143 0.1726
Trichomonas vaginalis PIKK family atypical protein kinase 0.1297 0.0758 0.9664
Trichomonas vaginalis conserved hypothetical protein 0.0815 0.0464 0.5863
Leishmania major cathepsin L-like protease 0.0357 0.0185 0.0507
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0095 0.0025 0.0249
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1581 0.0931 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183 0.0078 0.099
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0095 0.0025 0.0221
Brugia malayi Cathepsin L-like precursor 0.0224 0.0103 0.1102
Brugia malayi Papain family cysteine protease containing protein 0.0183 0.0078 0.0834
Entamoeba histolytica cysteine proteinase, putative 0.0311 0.0157 0.1738
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0095 0.0025 0.0249
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0357 0.0185 0.2351
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0083 0.0017 0.0005
Entamoeba histolytica cysteine proteinase 2 0.0183 0.0078 0.0705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0025 0.019
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.134 0.0784 1
Leishmania major cathepsin L-like protease 0.0311 0.0157 0.043
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.134 0.0784 0.2159
Brugia malayi Cathepsin L-like precursor 0.0311 0.0157 0.1677
Entamoeba histolytica cysteine protease, putative 0.0183 0.0078 0.0705
Loa Loa (eye worm) hypothetical protein 0.0815 0.0464 0.498
Entamoeba histolytica cysteine proteinase 1, putative 0.0183 0.0078 0.0705
Loa Loa (eye worm) hypothetical protein 0.0369 0.0192 0.2055
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.134 0.0784 0.2262
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.134 0.0784 0.2159
Loa Loa (eye worm) hypothetical protein 0.0311 0.0157 0.1677
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0311 0.0157 0.1895
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0095 0.0025 0.0249
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.134 0.0784 0.0772
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0376 0.0196 0.2074
Schistosoma mansoni cathepsin s 0.0088 0.002 0.0174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0357 0.0185 0.2351
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0271 0.0132 0.1577
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0494 0.0268 0.0772
Brugia malayi cathepsin L-like precursor 0.0224 0.0103 0.1102
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0508 0.0277 0.3445
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0017 0.0142
Entamoeba histolytica cysteine protease, putative 0.0183 0.0078 0.0705
Loa Loa (eye worm) hypothetical protein 0.0735 0.0415 0.4453
Brugia malayi Cathepsin L-like precursor 0.0311 0.0157 0.1677
Entamoeba histolytica cysteine protease, putative 0.0311 0.0157 0.1738
Schistosoma mansoni apoptosis regulator bax 0.0083 0.0017 0.0145
Echinococcus multilocularis cathepsin L cysteine protease 0.0311 0.0157 0.0144
Toxoplasma gondii FATC domain-containing protein 0.0765 0.0433 0.5628
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0357 0.0185 0.2351
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0271 0.0132 0.6349
Schistosoma mansoni cathepsin F (C01 family) 0.0311 0.0157 0.1646
Toxoplasma gondii preprocathepsin c precursor, putative 0.0095 0.0025 0.0318
Plasmodium vivax unspecified product 0.0183 0.0078 0.3288
Echinococcus multilocularis cathepsin b 0.1581 0.0931 0.0919
Trichomonas vaginalis PIKK family atypical protein kinase 0.1298 0.0758 0.9665
Brugia malayi Cytochrome P450 family protein 0.0117 0.0038 0.0405
Leishmania major cathepsin L-like protease 0.0311 0.0157 0.043
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0025 0.019
Brugia malayi cathepsin L-like cysteine proteinase 0.0095 0.0025 0.0258
Entamoeba histolytica cysteine proteinase, putative 0.0183 0.0078 0.0705
Trichomonas vaginalis PIKK family atypical protein kinase 0.0796 0.0452 0.5714
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.0747 0.9516
Trypanosoma cruzi major cysteine proteinase, putative 0.0095 0.0025 0.0069
Giardia lamblia Phosphatidylinositol 4-kinase 0.0271 0.0132 0.1414
Onchocerca volvulus 0.0311 0.0157 1
Entamoeba histolytica cysteine protease, putative 0.0183 0.0078 0.0705
Echinococcus multilocularis cathepsin L 0.0183 0.0078 0.0065
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0735 0.0415 0.0402
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0025 0.0221
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0311 0.0157 0.1895
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0376 0.0196 0.2408
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0083 0.0017 0.0005
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0271 0.0132 0.0119
Brugia malayi Cathepsin L-like precursor 0.0311 0.0157 0.1677
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0376 0.0196 0.0184
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0025 0.019
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0237 0.0111 0.032
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0088 0.002 0.0211
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0095 0.0025 0.0249
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0309 0.0155 0.1972
Schistosoma mansoni hypothetical protein 0.0083 0.0017 0.0145
Onchocerca volvulus 0.0311 0.0157 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0271 0.0132 0.1577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0311 0.0157 0.1895
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.071 0.04 0.429
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0183 0.0078 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0311 0.0157 0.1895
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0095 0.0025 0.0221
Loa Loa (eye worm) hypothetical protein 0.071 0.04 0.429
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0025 0.0221
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1079 0.0625 0.671
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0271 0.0132 0.6256
Loa Loa (eye worm) hypothetical protein 0.0224 0.0103 0.1102
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0765 0.0433 0.5521
Loa Loa (eye worm) hypothetical protein 0.0544 0.0298 0.3203
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.134 0.0784 0.2262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0858 0.049 0.6198
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0271 0.0132 0.6349
Trichomonas vaginalis PIKK family atypical protein kinase 0.1302 0.0761 0.9703
Entamoeba histolytica hypothetical protein 0.0947 0.0544 0.6845
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0271 0.0132 0.1413
Trypanosoma cruzi cruzipain precursor, putative 0.0357 0.0185 0.0532
Trichomonas vaginalis PIKK family atypical protein kinase 0.1321 0.0773 0.9851
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0357 0.0185 0.2351
Leishmania major phosphatidylinositol kinase, putative 0.0271 0.0132 0.0362
Trichomonas vaginalis PIKK family atypical protein kinase 0.134 0.0784 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0311 0.0157 0.7688
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0095 0.0025 0.019
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0271 0.0132 0.0379
Trichomonas vaginalis PIKK family atypical protein kinase 0.1321 0.0773 0.9851
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0376 0.0196 0.255
Schistosoma mansoni hypothetical protein 0.0083 0.0017 0.0145

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 9.8 uM Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay ChEMBL. 20970893
IC50 (functional) = 16.6 uM Cytotoxicity against human K562 cells after 24 hrs by MTT assay ChEMBL. 20970893
IC50 (functional) = 28.7 uM Cytotoxicity against human HT-29 cells after 24 hrs by MTT assay ChEMBL. 20970893

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 20970893

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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