TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 572.454 | Formula: C32H22BrN5O
H donors: 2 H acceptors: 2 LogP: 8.75 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: Brc1ccc(cc1)c1nc2n(c1Nc1ccccc1)cc(cc2)c1[nH]c2c(n1)ccc(c2)Oc1ccccc1
InChi: 1S/C32H22BrN5O/c33-23-14-11-21(12-15-23)30-32(34-24-7-3-1-4-8-24)38-20-22(13-18-29(38)37-30)31-35-27-17-16-26(19-28(27)36-31)39-25-9-5-2-6-10-25/h1-20,34H,(H,35,36)
InChiKey: ODZYCPVRFIWQQY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	tubulin beta-1 chain	0.0452	1	1
Brugia malayi	Tubulin alpha-2 chain	0.0342	0.7446	0.7446
Leishmania major	beta tubulin	0.0452	1	1
Leishmania major	beta tubulin	0.0452	1	1
Echinococcus multilocularis	tubulin delta chain	0.0106	0.1984	0.1984
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0203	0.4233	0.2805
Giardia lamblia	Epsilon tubulin	0.0106	0.1984	0.1405
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0116	0.2216	0.2216
Loa Loa (eye worm)	alpha-tubulin	0.0342	0.7446	0.7446
Echinococcus multilocularis	ATP binding cassette sub family G	0.0051	0.069	0.069
Trichomonas vaginalis	tubulin beta chain, putative	0.0342	0.7446	0.6814
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0251	0.5327	0.417
Echinococcus granulosus	beta tubulin	0.0452	1	1
Trichomonas vaginalis	tubulin, putative	0.0452	1	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.4233	0.4233
Plasmodium falciparum	tubulin gamma chain	0.0245	0.5197	0.5197
Trypanosoma cruzi	zeta tubulin, putative	0.0106	0.1984	0.1984
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0251	0.5327	0.5327
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0106	0.1984	0.1984
Trichomonas vaginalis	tubulin gamma chain, putative	0.0245	0.5197	0.4008
Leishmania major	alpha tubulin	0.0342	0.7446	0.7446
Loa Loa (eye worm)	tubulin gamma chain	0.0245	0.5197	0.5197
Brugia malayi	MH2 domain containing protein	0.0117	0.222	0.222
Echinococcus multilocularis	tubulin alpha 3 chain	0.0342	0.7446	0.7446
Trypanosoma brucei	beta tubulin	0.0245	0.5197	0.4842
Echinococcus granulosus	tubulin alpha	0.0245	0.5197	0.5197
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0116	0.2216	0.2216
Schistosoma mansoni	tubulin subunit beta	0.0452	1	1
Leishmania major	ATP-binding cassette protein subfamily G, member 6, putative	0.0051	0.069	0.069
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0203	0.4233	0.4233
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0085	0.1496	0.1496
Giardia lamblia	Gamma tubulin	0.0245	0.5197	0.4851
Loa Loa (eye worm)	BEN-1 protein	0.0452	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0452	1	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0342	0.7446	0.7446
Leishmania major	alpha tubulin	0.0342	0.7446	0.7446
Echinococcus multilocularis	tubulin epsilon chain	0.0245	0.5197	0.5197
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0342	0.7446	0.6814
Trypanosoma brucei	epsilon tubulin	0.0245	0.5197	0.4842
Echinococcus granulosus	Tubulin alpha 1 chain	0.0342	0.7446	0.7446
Loa Loa (eye worm)	tubulin alpha chain	0.0342	0.7446	0.7446
Leishmania major	beta tubulin	0.0452	1	1
Echinococcus multilocularis	beta tubulin	0.0452	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0342	0.7446	0.7446
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0251	0.5327	0.5327
Brugia malayi	Tubulin beta chain	0.0106	0.1984	0.1984
Echinococcus multilocularis	tubulin alpha chain	0.0342	0.7446	0.7446
Loa Loa (eye worm)	hypothetical protein	0.0085	0.1496	0.1496
Schistosoma mansoni	alpha tubulin	0.0342	0.7446	0.7446
Schistosoma mansoni	tubulin subunit beta	0.0452	1	1
Schistosoma mansoni	tubulin subunit delta	0.0106	0.1984	0.1984
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0342	0.7446	0.7446
Loa Loa (eye worm)	hypothetical protein	0.0342	0.7446	0.7446
Schistosoma mansoni	lipoxygenase	0.0116	0.2216	0.2216
Echinococcus multilocularis	tumor necrosis factor receptor superfamily	0.013	0.2537	0.2537
Loa Loa (eye worm)	tubulin beta chain	0.0106	0.1984	0.1984
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0342	0.7446	0.7446
Schistosoma mansoni	ABC transporter	0.0043	0.0512	0.0512
Trypanosoma brucei	tubulin gamma chain	0.0245	0.5197	0.4842
Leishmania major	beta tubulin	0.0452	1	1
Echinococcus granulosus	tubulin beta 1 chain	0.0452	1	1
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0295	0.635	1
Onchocerca volvulus		0.0139	0.2732	0.5128
Schistosoma mansoni	alpha tubulin	0.0342	0.7446	0.7446
Echinococcus multilocularis	tubulin alpha chain	0.0342	0.7446	0.7446
Leishmania major	alpha tubulin	0.0342	0.7446	0.7446
Schistosoma mansoni	tubulin subunit gamma	0.0245	0.5197	0.5197
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0245	0.5197	0.5197
Entamoeba histolytica	tubulin family protein	0.0452	1	1
Echinococcus granulosus	geminin	0.0165	0.3352	0.3352
Plasmodium vivax	tubulin beta chain, putative	0.0452	1	1
Toxoplasma gondii	beta-1 tubulin, putative	0.0452	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0342	0.7446	0.6814
Brugia malayi	Tubulin beta chain	0.0139	0.2732	0.2732
Leishmania major	delta tubulin, putative	0.0106	0.1984	0.1984
Trypanosoma brucei	tubulin delta chain	0.0106	0.1984	0.139
Leishmania major	ATP-binding cassette protein subfamily G, member 4, putative	0.0051	0.069	0.069
Toxoplasma gondii	beta-tubulin, putative	0.0452	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0342	0.7446	0.7446
Mycobacterium tuberculosis	Probable conserved transmembrane ATP-binding protein ABC transporter	0.0042	0.0496	0.0845
Echinococcus multilocularis	tubulin alpha 1C chain	0.0342	0.7446	0.7446
Echinococcus multilocularis	geminin	0.0165	0.3352	0.3352
Echinococcus granulosus	Ankyrin	0.0085	0.1496	0.1496
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.029	0.029
Schistosoma mansoni	tubulin subunit epsilon	0.0245	0.5197	0.5197
Mycobacterium leprae	cell division protein FtsZ	0.0106	0.1984	1
Brugia malayi	Death domain containing protein	0.0085	0.1496	0.1496
Echinococcus granulosus	tubulin alpha chain	0.0342	0.7446	0.7446
Plasmodium vivax	tubulin epsilon chain, putative	0.0245	0.5197	0.5197
Trichomonas vaginalis	tubulin, putative	0.0139	0.2732	0.0932
Echinococcus granulosus	ATP binding cassette sub family G	0.0051	0.069	0.069
Onchocerca volvulus	Netrin receptor homolog	0.0085	0.1496	0.2809
Brugia malayi	Protein kinase domain containing protein	0.0085	0.1496	0.1496
Brugia malayi	beta-tubulin, identical	0.0452	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0452	1	1
Leishmania major	beta tubulin	0.0452	1	1
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0085	0.1496	0.1496
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0085	0.1496	0.1496
Loa Loa (eye worm)	hypothetical protein	0.0085	0.1496	0.1496
Leishmania major	gamma-tubulin	0.0245	0.5197	0.5197
Trypanosoma cruzi	beta tubulin, putative	0.0452	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0452	1	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0342	0.7446	0.7446
Trichomonas vaginalis	tubulin alpha chain, putative	0.0139	0.2732	0.0932
Schistosoma mansoni	ankyrin 23/unc44	0.0085	0.1496	0.1496
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0342	0.7446	0.6814
Trypanosoma brucei	alpha tubulin, putative	0.0139	0.2732	0.2193
Loa Loa (eye worm)	hypothetical protein	0.0033	0.029	0.029
Leishmania major	epsilon tubulin, putative	0.0245	0.5197	0.5197
Echinococcus granulosus	tubulin alpha 1C chain	0.0342	0.7446	0.7446
Trypanosoma cruzi	epsilon tubulin, putative	0.0245	0.5197	0.5197
Leishmania major	beta tubulin	0.0452	1	1
Leishmania major	alpha tubulin	0.0342	0.7446	0.7446
Echinococcus granulosus	tubulin alpha chain	0.0342	0.7446	0.7446
Toxoplasma gondii	alpha tubulin TUBA1	0.0342	0.7446	0.7446
Giardia lamblia	Alpha-tubulin	0.0342	0.7446	0.7262
Leishmania major	alpha tubulin	0.0342	0.7446	0.7446
Echinococcus multilocularis	Tubulin beta 2C chain	0.0452	1	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0452	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0452	1	1
Leishmania major	beta tubulin	0.0452	1	1
Schistosoma mansoni	hypothetical protein	0.0165	0.3352	0.3352
Echinococcus granulosus	alpha tubulin	0.0342	0.7446	0.7446
Echinococcus granulosus	tumor necrosis factor receptor superfamily	0.013	0.2537	0.2537
Echinococcus multilocularis	Tubulin beta 2C chain	0.0452	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0139	0.2732	0.0932
Trichomonas vaginalis	tubulin alpha chain, putative	0.0245	0.5197	0.4008
Echinococcus granulosus	netrin receptor unc 5	0.0085	0.1496	0.1496
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0251	0.5327	0.417
Echinococcus multilocularis	TNFR CD27 30 40 95 cysteine rich region	0.013	0.2537	0.2537
Leishmania major	beta tubulin	0.0452	1	1
Echinococcus multilocularis	ATP binding cassette sub family G	0.0051	0.069	0.069
Echinococcus multilocularis	netrin receptor unc 5	0.0085	0.1496	0.1496
Entamoeba histolytica	tubulin family protein	0.0452	1	1
Echinococcus multilocularis	ATP binding cassette sub family G	0.0051	0.069	0.069
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0106	0.1984	0.3381
Giardia lamblia	Beta tubulin	0.0452	1	1
Echinococcus granulosus	tubulin beta 4A class IVa	0.0452	1	1
Leishmania major	beta tubulin	0.0452	1	1
Brugia malayi	Tubulin gamma chain	0.0245	0.5197	0.5197
Echinococcus granulosus	tubulin gamma 1 chain	0.0245	0.5197	0.5197
Schistosoma mansoni	tubulin subunit alpha	0.0342	0.7446	0.7446
Leishmania major	alpha tubulin	0.0342	0.7446	0.7446
Echinococcus multilocularis	tubulin alpha chain	0.0342	0.7446	0.7446
Toxoplasma gondii	ATP-binding cassette G family transporter ABCG84	0.0051	0.069	0.069
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0251	0.5327	0.499
Leishmania major	beta tubulin	0.0452	1	1
Plasmodium vivax	delta tubulin, putative	0.0106	0.1984	0.1984
Echinococcus multilocularis	Tubulin beta 2C chain	0.0452	1	1
Trypanosoma brucei	beta tubulin	0.0452	1	1
Trypanosoma brucei	epsilon tubulin	0.0245	0.5197	0.4842
Leishmania major	alpha tubulin	0.0342	0.7446	0.7446
Trichomonas vaginalis	tubulin alpha chain, putative	0.0452	1	1
Plasmodium falciparum	alpha tubulin 2	0.0342	0.7446	0.7446
Leishmania major	beta tubulin	0.0452	1	1
Echinococcus granulosus	tubulin delta chain	0.0106	0.1984	0.1984
Echinococcus granulosus	tubulin alpha 3 chain	0.0342	0.7446	0.7446
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0647	0.0647
Leishmania major	beta tubulin	0.0452	1	1
Leishmania major	alpha tubulin	0.0342	0.7446	0.7446
Leishmania major	beta tubulin	0.0452	1	1
Loa Loa (eye worm)	tubulin beta chain	0.0452	1	1
Trypanosoma cruzi	tubulin delta chain	0.0106	0.1984	0.1984
Echinococcus granulosus	death domain containing protein	0.0085	0.1496	0.1496
Brugia malayi	Uncoordinated protein 44	0.0085	0.1496	0.1496
Loa Loa (eye worm)	BEN-1 protein	0.0452	1	1
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0085	0.1496	0.1496
Leishmania major	beta tubulin	0.0452	1	1
Trypanosoma cruzi	alpha tubulin, putative	0.0342	0.7446	0.7446
Trypanosoma brucei	alpha tubulin	0.0342	0.7446	0.7257
Trichomonas vaginalis	tubulin beta chain, putative	0.0342	0.7446	0.6814
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0236	0.4981	0.3738
Brugia malayi	Tubulin alpha chain	0.0106	0.1984	0.1984
Toxoplasma gondii	alpha-tubulin I, putative	0.0342	0.7446	0.7446
Echinococcus granulosus	Tubulin beta 2C chain	0.0452	1	1
Plasmodium falciparum	tubulin beta chain	0.0452	1	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.0245	0.5197	0.5197
Schistosoma mansoni	hypothetical protein	0.0165	0.3352	0.3352
Loa Loa (eye worm)	tubulin alpha 2	0.0097	0.1768	0.1768
Trichomonas vaginalis	tubulin alpha chain, putative	0.0139	0.2732	0.0932
Loa Loa (eye worm)	tubulin alpha chain	0.0342	0.7446	0.7446
Schistosoma mansoni	tubulin subunit beta	0.0106	0.1984	0.1984
Echinococcus multilocularis	tubulin subunit TubB	0.0342	0.7446	0.7446
Trichomonas vaginalis	tubulin beta chain, putative	0.0342	0.7446	0.6814
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0274	0.5869	1
Loa Loa (eye worm)	tubulin alpha 2	0.0236	0.4981	0.4981
Treponema pallidum	cell division protein FtsZ	0.0106	0.1984	0.5
Leishmania major	beta tubulin	0.0452	1	1
Loa Loa (eye worm)	ABC transporter	0.0043	0.0512	0.0512
Brugia malayi	Tubulin alpha chain	0.0342	0.7446	0.7446
Schistosoma mansoni	tubulin subunit beta	0.0452	1	1
Echinococcus multilocularis	tubulin beta 1 chain	0.0452	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0342	0.7446	0.7446
Trypanosoma brucei	zeta tubulin	0.0106	0.1984	0.139
Echinococcus granulosus	Tubulin beta 2C chain	0.0452	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0452	1	1
Giardia lamblia	Beta tubulin	0.0452	1	1
Leishmania major	alpha tubulin	0.0342	0.7446	0.7446
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0085	0.1496	0.1496
Echinococcus multilocularis	tubulin alpha 1C chain	0.0342	0.7446	0.7446
Trypanosoma brucei	alpha tubulin	0.0342	0.7446	0.7257
Leishmania major	alpha tubulin	0.0342	0.7446	0.7446
Echinococcus granulosus	tubulin subunit beta	0.0452	1	1
Trichomonas vaginalis	tubulin, putative	0.0139	0.2732	0.0932
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0051	0.069	0.1087
Echinococcus multilocularis	Tubulin beta 2C chain	0.0452	1	1
Echinococcus granulosus	beta tubulin	0.0452	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0139	0.2732	0.0932
Echinococcus multilocularis	tubulin alpha	0.0245	0.5197	0.5197
Brugia malayi	tubulin alpha chain - mouse	0.0342	0.7446	0.7446
Plasmodium falciparum	tubulin delta chain, putative	0.0106	0.1984	0.1984
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0647	0.0647
Loa Loa (eye worm)	beta-tubulin	0.0452	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0647	0.0647
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0647	0.0647
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0106	0.1984	0.5
Trypanosoma brucei	beta tubulin	0.0452	1	1
Schistosoma mansoni	ATP-binding cassette sub-family g2 (white protein) (abcg2)	0.0051	0.069	0.069
Leishmania major	beta tubulin	0.0452	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0342	0.7446	0.7446
Trypanosoma brucei	beta tubulin	0.0452	1	1
Loa Loa (eye worm)	tubulin alpha 2	0.0236	0.4981	0.4981
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0342	0.7446	0.7446
Echinococcus multilocularis	tubulin subunit beta	0.0452	1	1
Schistosoma mansoni	hypothetical protein	0.0085	0.1496	0.1496
Echinococcus multilocularis	tubulin alpha chain	0.0342	0.7446	0.7446
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0236	0.4981	0.4981
Toxoplasma gondii	beta tubulin	0.0452	1	1
Brugia malayi	alpha-tubulin	0.0342	0.7446	0.7446
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0251	0.5327	0.417
Loa Loa (eye worm)	hypothetical protein	0.0236	0.4981	0.4981
Leishmania major	zeta tubulin, putative	0.0106	0.1984	0.1984
Brugia malayi	Tubulin alpha-2 chain	0.0342	0.7446	0.7446
Echinococcus granulosus	Tubulin beta 2C chain	0.0452	1	1
Trypanosoma cruzi	ATP-binding cassette protein, putative	0.0051	0.069	0.069
Schistosoma mansoni	tubulin subunit beta	0.0452	1	1
Schistosoma mansoni	tumor necrosis factor receptor related	0.013	0.2537	0.2537
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0251	0.5327	0.417
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0251	0.5327	0.4981
Plasmodium vivax	tubulin gamma chain, putative	0.0245	0.5197	0.5197
Trichomonas vaginalis	tubulin gamma chain, putative	0.0452	1	1
Echinococcus granulosus	peroxisome assembly protein 26	0.0342	0.7446	0.7446
Trichomonas vaginalis	tubulin gamma chain, putative	0.0245	0.5197	0.4008
Trypanosoma brucei	zeta tubulin, putative	0.0106	0.1984	0.139
Echinococcus multilocularis	tubulin alpha chain	0.0342	0.7446	0.7446
Trypanosoma cruzi	tubulin delta chain	0.0106	0.1984	0.1984
Echinococcus granulosus	tubulin alpha chain	0.0342	0.7446	0.7446
Echinococcus granulosus	tubulin epsilon chain	0.0245	0.5197	0.5197
Schistosoma mansoni	hypothetical protein	0.0042	0.0496	0.0496
Plasmodium falciparum	alpha tubulin 1	0.0342	0.7446	0.7446
Plasmodium vivax	tubulin alpha chain, putative	0.0342	0.7446	0.7446
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0251	0.5327	0.417
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0251	0.5327	0.417
Schistosoma mansoni	lipoxygenase	0.0081	0.1404	0.1404
Brugia malayi	tubulin alpha-2 chain	0.0342	0.7446	0.7446
Loa Loa (eye worm)	tubulin beta-2A chain	0.0452	1	1
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0251	0.5327	0.9077
Schistosoma mansoni	hypothetical protein	0.0033	0.029	0.029
Trypanosoma brucei	beta tubulin	0.0452	1	1
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0342	0.7446	0.7446
Leishmania major	beta tubulin	0.0452	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0342	0.7446	0.6814
Echinococcus multilocularis	hypothetical protein	0.0342	0.7446	0.7446
Trypanosoma cruzi	tubulin gamma chain	0.0245	0.5197	0.5197
Giardia lamblia	Alpha-tubulin	0.0342	0.7446	0.7262
Giardia lamblia	Beta tubulin	0.0452	1	1
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0051	0.069	0.1087
Echinococcus granulosus	tubulin alpha chain	0.0342	0.7446	0.7446
Plasmodium falciparum	ABC transporter G family member 2	0.0051	0.069	0.069
Plasmodium vivax	ABC transporter G family member 2, putative	0.0051	0.069	0.069
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.222	0.222
Plasmodium vivax	tubulin alpha chain, putative	0.0342	0.7446	0.7446
Entamoeba histolytica	tubulin alpha chain, putative	0.0342	0.7446	0.7257
Trypanosoma cruzi	zeta tubulin, putative	0.0106	0.1984	0.1984
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0251	0.5327	0.4981
Giardia lamblia	Delta tubulin	0.0106	0.1984	0.1405
Echinococcus multilocularis	tubulin alpha 3 chain	0.0342	0.7446	0.7446
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0452	1	1
Trypanosoma cruzi	ABC transporter, putative	0.0051	0.069	0.069
Echinococcus granulosus	tubulin alpha chain	0.0342	0.7446	0.7446
Entamoeba histolytica	tubulin alpha-1 chain	0.0342	0.7446	0.7257
Schistosoma mansoni	netrin receptor unc5	0.0085	0.1496	0.1496
Leishmania major	alpha tubulin	0.0342	0.7446	0.7446
Echinococcus multilocularis	Ankyrin	0.0085	0.1496	0.1496
Echinococcus multilocularis	beta tubulin	0.0452	1	1
Leishmania major	beta tubulin	0.0452	1	1
Schistosoma mansoni	tubulin subunit beta	0.0452	1	1
Trypanosoma brucei	alpha tubulin	0.0342	0.7446	0.7257
Schistosoma mansoni	tubulin subunit beta	0.0452	1	1
Schistosoma mansoni	alpha tubulin	0.0342	0.7446	0.7446
Schistosoma mansoni	tubulin subunit alpha	0.0342	0.7446	0.7446
Trichomonas vaginalis	tubulin beta chain, putative	0.0342	0.7446	0.6814
Trichomonas vaginalis	tubulin beta chain, putative	0.0452	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0139	0.2732	0.0932
Echinococcus multilocularis	peroxisome assembly protein 26	0.0342	0.7446	0.7446
Echinococcus granulosus	ATP binding cassette sub family G	0.0051	0.069	0.069
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0021	0	0.5
Leishmania major	alpha tubulin	0.0342	0.7446	0.7446
Schistosoma mansoni	tubulin subunit alpha	0.0106	0.1984	0.1984
Brugia malayi	ABC transporter family protein	0.0043	0.0512	0.0512
Trypanosoma brucei	alpha tubulin	0.0342	0.7446	0.7257
Trypanosoma brucei	epsilon tubulin	0.0245	0.5197	0.4842
Onchocerca volvulus		0.0251	0.5327	1
Brugia malayi	Cell division protein ftsZ	0.0106	0.1984	0.1984
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0106	0.1984	0.1984
Echinococcus granulosus	tubulin subunit TubB	0.0342	0.7446	0.7446
Trypanosoma cruzi	epsilon tubulin, putative	0.0245	0.5197	0.5197
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0251	0.5327	0.8389
Trichomonas vaginalis	tubulin beta chain, putative	0.0342	0.7446	0.6814
Mycobacterium ulcerans	cell division protein FtsZ	0.0106	0.1984	0.3125
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0295	0.635	1
Entamoeba histolytica	tubulin gamma chain	0.0245	0.5197	0.4842
Echinococcus multilocularis	tubulin gamma 1 chain	0.0245	0.5197	0.5197
Echinococcus granulosus	ATP binding cassette sub family G	0.0051	0.069	0.069
Echinococcus granulosus	TNFR CD27 30 40 95 cysteine rich region	0.013	0.2537	0.2537
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.222	0.222
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0051	0.069	0.1087

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 31.83 ug ml-1	Antimicrobial activity against Escherichia coli after 24 hrs by ELISA	ChEMBL.	20934788

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1630654

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1463278