Detailed information for compound 1464353

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 363.759 | Formula: C16H17ClF3NO3
  • H donors: 1 H acceptors: 2 LogP: 4.73 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CN(c1cc2O[C@H](C(=Cc2cc1Cl)C(=O)O)C(F)(F)F)C)C
  • InChi: 1S/C16H17ClF3NO3/c1-8(2)7-21(3)12-6-13-9(5-11(12)17)4-10(15(22)23)14(24-13)16(18,19)20/h4-6,8,14H,7H2,1-3H3,(H,22,23)/t14-/m1/s1
  • InChiKey: NTNQMVISBBFDRT-CQSZACIVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Starlite/ChEMBL References
Homo sapiens prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0012 0.0115 0.0113
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.0976 0.0975
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0115 0.0113
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.06 1 1
Schistosoma mansoni notch 0.0021 0.0253 0.0161
Echinococcus multilocularis dnaJ subfamily B 0.0255 0.4204 0.4203
Onchocerca volvulus Peroxidasin homolog 0.0063 0.0976 0.0872
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0346 0.0345
Schistosoma mansoni cercarial elastase (S01 family) 0.06 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Brugia malayi Trypsin family protein 0.06 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0139 0.0138
Loa Loa (eye worm) hypothetical protein 0.0012 0.0115 0.0113
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0089 0.1401 0.14
Loa Loa (eye worm) hypothetical protein 0.0089 0.1401 0.14
Schistosoma mansoni hypothetical protein 0.0437 0.7254 0.7228
Loa Loa (eye worm) RNA binding protein 0.004 0.0573 0.0572
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0346 0.0346
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.06 1 1
Trichomonas vaginalis importin beta-1, putative 0.0015 0.0153 0.0179
Schistosoma mansoni zinc finger protein 0.0012 0.0115 0.0021
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.0346 0.0345
Trichomonas vaginalis penicillin-binding protein, putative 0.0089 0.1401 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0104 0.0102
Onchocerca volvulus 0.06 1 1
Brugia malayi Trypsin family protein 0.06 1 1
Brugia malayi beta-lactamase family protein 0.0089 0.1401 0.1401
Loa Loa (eye worm) hypothetical protein 0.0089 0.1401 0.14
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0346 0.0346
Loa Loa (eye worm) transcription factor SMAD2 0.0162 0.264 0.2639
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0346 0.0346
Echinococcus multilocularis notch 0.0021 0.0253 0.0252
Onchocerca volvulus 0.0021 0.0253 0.014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0345
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0013 0.0131 0.013
Trypanosoma brucei importin beta-1 subunit, putative 0.0018 0.0211 0.0826
Loa Loa (eye worm) hypothetical protein 0.0063 0.0976 0.0975
Loa Loa (eye worm) hypothetical protein 0.0012 0.0115 0.0113
Mycobacterium ulcerans esterase/lipase LipP 0.0089 0.1401 0.1303
Brugia malayi Animal haem peroxidase family protein 0.0063 0.0976 0.0976
Onchocerca volvulus Slit protein homolog 0.0021 0.0253 0.014
Echinococcus multilocularis enteropeptidase 0.06 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.0346 0.0345
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0346 0.0346
Leishmania major 4-coumarate:coa ligase-like protein 0.0016 0.0183 0.0611
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0032 0.0438 0.0347
Mycobacterium leprae Probable lipase LipE 0.0089 0.1401 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0089 0.1401 0.14
Loa Loa (eye worm) hypothetical protein 0.0049 0.0725 0.0724
Brugia malayi MH1 domain containing protein 0.0006 0.0011 0.0011
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.0094 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0346 0.0346
Leishmania major hypothetical protein, conserved 0.0089 0.1401 1
Brugia malayi Muscle positioning protein 4 0.0021 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0567 0.9448 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0013 0.0131 0.013
Trichomonas vaginalis D-aminoacylase, putative 0.0089 0.1401 1
Brugia malayi nuclear receptor RXR 0.0014 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0014 0.0139 0.0138
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.0346 0.0345
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0346 0.0345
Brugia malayi hypothetical protein 0.0012 0.0115 0.0115
Echinococcus granulosus glycoprotein Antigen 5 0.06 1 1
Schistosoma mansoni hypothetical protein 0.0437 0.7254 0.7228
Brugia malayi Animal haem peroxidase family protein 0.0063 0.0976 0.0976
Schistosoma mansoni nuclear receptor 0.0012 0.0115 0.0021
Brugia malayi TAR-binding protein 0.004 0.0573 0.0573
Brugia malayi hypothetical protein 0.0012 0.0115 0.0115
Echinococcus multilocularis neurogenic locus protein delta 0.0021 0.0253 0.0252
Loa Loa (eye worm) hypothetical protein 0.0063 0.0976 0.0975
Loa Loa (eye worm) beta-lactamase 0.0089 0.1401 0.14
Echinococcus multilocularis GPCR, family 2 0.0022 0.0286 0.0285
Loa Loa (eye worm) nuclear factor I 0.0006 0.0011 0.001
Echinococcus granulosus geminin 0.0437 0.7254 0.7254
Schistosoma mansoni nuclear receptor 0.0012 0.0115 0.0021
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.06 1 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0012 0.0104 0.001
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0115 0.0021
Brugia malayi Delta serrate ligand family protein 0.0021 0.0253 0.0253
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.0346 0.0234
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0013 0.0131 0.021
Brugia malayi EGF-like domain containing protein 0.0021 0.0253 0.0253
Schistosoma mansoni hypothetical protein 0.0021 0.0253 0.0161
Loa Loa (eye worm) hypothetical protein 0.0012 0.0115 0.0113
Brugia malayi RNA recognition motif domain containing protein 0.004 0.0573 0.0573
Loa Loa (eye worm) nuclear receptor NHR-67 0.0012 0.0115 0.0113
Loa Loa (eye worm) hypothetical protein 0.06 1 1
Leishmania major GTP-binding protein, putative 0.0013 0.0131 0.021
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0192 0.3141 0.314
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0396 1
Schistosoma mansoni cpg binding protein 0.0018 0.021 0.0117
Loa Loa (eye worm) trypsin family protein 0.06 1 1
Mycobacterium tuberculosis Conserved protein 0.0089 0.1401 0.139
Loa Loa (eye worm) hypothetical protein 0.0012 0.0115 0.0113
Toxoplasma gondii histone lysine methyltransferase SET1 0.0034 0.0479 0.2896
Echinococcus multilocularis nuclear receptor nhr 48 0.0012 0.0115 0.0113
Schistosoma mansoni hypothetical protein 0.0022 0.0286 0.0194
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0013 0.0131 0.021
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.0548 0.0458
Loa Loa (eye worm) hypothetical protein 0.06 1 1
Echinococcus multilocularis neurogenic locus protein delta 0.0021 0.0253 0.0252
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0104 0.0102
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.0346 0.0254
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0253 0.0253
Trichomonas vaginalis esterase, putative 0.0089 0.1401 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0346 0.0345
Plasmodium vivax hypothetical protein, conserved 0.0089 0.1401 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0346 0.0346
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0016 0.0183 0.007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0071 0.1103 0.1103
Brugia malayi EGF-like domain containing protein 0.0021 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0345
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.0346 0.0345
Echinococcus granulosus GPCR family 2 0.0022 0.0286 0.0285
Mycobacterium ulcerans lipase LipD 0.0089 0.1401 0.1303
Schistosoma mansoni cercarial elastase (S01 family) 0.06 1 1
Brugia malayi Smad1 0.0011 0.0094 0.0094
Onchocerca volvulus 0.06 1 1
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0396 0.2256
Mycobacterium tuberculosis Probable hydrolase 0.0089 0.1401 0.139
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0016 0.0183 0.007
Brugia malayi orphan nuclear receptor NR2E1 0.0012 0.0115 0.0115
Onchocerca volvulus Dual oxidase homolog 0.0063 0.0976 0.0872
Loa Loa (eye worm) hypothetical protein 0.0029 0.0396 0.0395
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0089 0.1401 0.1319
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0559 0.9309 0.9309
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0015 0.0153 0.0179
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0115 0.0113
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.0094 0.0093
Schistosoma mansoni cpg binding protein 0.0019 0.0227 0.0134
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Schistosoma mansoni coup transcription factor 0.0026 0.0346 0.0254
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0012 0.0115 0.0115
Schistosoma mansoni tar DNA-binding protein 0.004 0.0573 0.0484
Echinococcus granulosus beta LACTamase domain containing family member 0.0089 0.1401 0.14
Mycobacterium ulcerans hypothetical protein 0.0089 0.1401 0.1303
Loa Loa (eye worm) CXXC zinc finger family protein 0.0018 0.021 0.0208
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0013 0.0131 0.0931
Echinococcus granulosus nuclear receptor nhr 48 0.0012 0.0115 0.0113
Onchocerca volvulus Peroxidasin homolog 0.0063 0.0976 0.0872
Loa Loa (eye worm) hypothetical protein 0.0063 0.0976 0.0975
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0022 0.0286 0.0285
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0016 0.0183 0.007
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0022 0.0286 0.0285
Echinococcus granulosus protein jagged 2 0.0021 0.0253 0.0252
Brugia malayi nuclear hormone receptor 0.0012 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0049 0.0725 0.0637
Trypanosoma brucei importin beta-1 subunit, putative 0.0018 0.0211 0.0826
Schistosoma mansoni hypothetical protein 0.0021 0.0253 0.0161
Brugia malayi hypothetical protein 0.06 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.06 1 1
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0021 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0211 0.021
Onchocerca volvulus 0.0021 0.0253 0.014
Onchocerca volvulus 0.0018 0.021 0.0096
Brugia malayi Blistered cuticle protein 3 0.0063 0.0976 0.0976
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.0346 0.0254
Brugia malayi Cadherin domain containing protein 0.0021 0.0253 0.0253
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0139 0.0139
Giardia lamblia High cysteine protein 0.0021 0.0253 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0976 0.0975
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0089 0.1401 0.1401
Echinococcus multilocularis smad 0.0011 0.0094 0.0093
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0183 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0346 0.0346
Schistosoma mansoni hypothetical protein 0.0022 0.0286 0.0194
Loa Loa (eye worm) hypothetical protein 0.0089 0.1401 0.14
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0012 0.0104 0.0102
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0032 0.0438 0.0437
Onchocerca volvulus 0.0016 0.0183 0.0069
Loa Loa (eye worm) hypothetical protein 0.0012 0.0113 0.0112
Leishmania major importin beta-1 subunit, putative 0.0015 0.0153 0.0385
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.001
Schistosoma mansoni cpg binding protein 0.0019 0.0227 0.0134
Echinococcus multilocularis tar DNA binding protein 0.004 0.0573 0.0572
Schistosoma mansoni cercarial elastase (S01 family) 0.06 1 1
Brugia malayi EGF-like domain containing protein 0.0021 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0089 0.1401 0.14
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0089 0.1401 0.139
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0183 0.007
Entamoeba histolytica acyl-coA synthetase, putative 0.0016 0.0183 1
Mycobacterium ulcerans beta-lactamase 0.0089 0.1401 0.1303
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0396 0.2256
Echinococcus granulosus neurogenic locus notch protein 4 0.0021 0.0253 0.0252
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Brugia malayi beta-lactamase 0.0089 0.1401 0.1401
Echinococcus multilocularis protein jagged 1 0.0021 0.0253 0.0252
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.06 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0976 0.0975
Echinococcus multilocularis neural cadherin 0.0021 0.0253 0.0252
Echinococcus granulosus TGF beta signal transducer SmadC 0.0011 0.0094 0.0093
Loa Loa (eye worm) latrophilin receptor protein 2 0.0022 0.0286 0.0285
Plasmodium falciparum acyl-CoA synthetase 0.0012 0.0113 0.0333
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0396 1
Brugia malayi Isocitrate dehydrogenase 0.0012 0.0104 0.0104
Leishmania major hypothetical protein, conserved 0.0029 0.0396 0.2256
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0012 0.0115 0.0021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Brugia malayi nuclear receptor NHR-67 0.0012 0.0115 0.0115
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0346 0.0254
Brugia malayi tailless protein 0.0012 0.0115 0.0115
Echinococcus granulosus fibropellin Ia 0.0021 0.0253 0.0252
Schistosoma mansoni cercarial elastase (S01 family) 0.06 1 1
Brugia malayi EGF-like domain containing protein 0.0021 0.0253 0.0253
Plasmodium vivax acyl-CoA synthetase, putative 0.0012 0.0113 0.0075
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0253 0.0253
Toxoplasma gondii HEAT repeat-containing protein 0.0018 0.0211 0.0826
Trypanosoma cruzi hypothetical protein, conserved 0.0089 0.1401 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0071 0.1103 0.1102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0346 0.0345
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0396 0.2256
Loa Loa (eye worm) hypothetical protein 0.06 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0346 0.0345
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Echinococcus granulosus notch 0.0021 0.0253 0.0252
Loa Loa (eye worm) hypothetical protein 0.0012 0.0115 0.0113
Schistosoma mansoni notch 0.0021 0.0253 0.0161
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0115 0.0113
Schistosoma mansoni ran 0.0013 0.0131 0.0037
Mycobacterium tuberculosis Probable esterase LipL 0.0089 0.1401 0.139
Entamoeba histolytica hypothetical protein 0.0015 0.0153 0.4365
Schistosoma mansoni cercarial elastase (S01 family) 0.06 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0162 0.264 0.2639
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Echinococcus multilocularis geminin 0.0437 0.7254 0.7254
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0013 0.0131 0.0131
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0183 0.0086
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0012 0.0113 0.0012
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.0346 0.0254
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.06 1 1
Onchocerca volvulus Peroxidase homolog 0.0063 0.0976 0.0872
Schistosoma mansoni hypothetical protein 0.06 1 1
Brugia malayi hypothetical protein 0.0019 0.0223 0.0223
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0183 0.007
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0345
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0346 0.0346
Onchocerca volvulus 0.0063 0.0976 0.0872
Echinococcus multilocularis peroxidasin 0.0063 0.0976 0.0975
Schistosoma mansoni importin beta-1 0.0018 0.0211 0.0118
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0032 0.0438 0.0437
Echinococcus granulosus dnaJ subfamily B 0.0255 0.4204 0.4203
Schistosoma mansoni ran 0.0013 0.0131 0.0037
Brugia malayi beta-lactamase family protein 0.0089 0.1401 0.1401
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0012 0.0115 0.0021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.0139 0.0138
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0089 0.1401 0.1303
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0345
Brugia malayi hypothetical protein 0.0063 0.0976 0.0976
Trypanosoma cruzi importin beta-1 subunit, putative 0.0015 0.0153 0.0385
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0115 0.0113
Loa Loa (eye worm) TAR-binding protein 0.004 0.0573 0.0572
Brugia malayi ecdysteroid receptor 0.0026 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.06 1 1
Loa Loa (eye worm) Notch2 0.0021 0.0253 0.0252
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.06 1 1
Brugia malayi nuclear receptor NHR-88 0.0026 0.0346 0.0346
Brugia malayi Calcitonin receptor-like protein seb-1 0.0071 0.1103 0.1103
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.06 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0346 0.0345
Brugia malayi hypothetical protein 0.0014 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0016 0.0183 0.0182
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.0976 0.0975
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0345
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0021 0.0253 0.014
Echinococcus multilocularis Smad4 0.0011 0.0094 0.0093
Schistosoma mansoni cercarial elastase (S01 family) 0.06 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.06 1 1
Schistosoma mansoni hypothetical protein 0.0022 0.0286 0.0194
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0089 0.1401 0.139
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0032 0.0438 0.0437
Loa Loa (eye worm) hypothetical protein 0.06 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0013 0.0131 0.013
Echinococcus multilocularis isocitrate dehydrogenase 0.0012 0.0104 0.0102
Trypanosoma brucei hypothetical protein, conserved 0.0089 0.1401 1
Echinococcus multilocularis protein jagged 1 0.0021 0.0253 0.0252
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0345
Echinococcus granulosus Smad4 0.0011 0.0094 0.0093
Loa Loa (eye worm) hypothetical protein 0.0063 0.0976 0.0975
Loa Loa (eye worm) nuclear hormone receptor 0.0012 0.0115 0.0113
Schistosoma mansoni cercarial elastase (S01 family) 0.06 1 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0012 0.0115 0.0113
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0346 0.0234
Echinococcus granulosus neurogenic locus protein delta 0.0021 0.0253 0.0252
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0346 0.0345
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0012 0.0115 0.0113
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.004 0.0573 0.0572
Onchocerca volvulus 0.0026 0.0346 0.0234
Brugia malayi latrophilin 2 splice variant baaae 0.0049 0.0725 0.0725
Brugia malayi Trypsin-like protease protein 5 0.06 1 1
Brugia malayi MH2 domain containing protein 0.0011 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.0013 0.0127 0.0033
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0022 0.0286 0.0286
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.0346 0.0345
Schistosoma mansoni tar DNA-binding protein 0.004 0.0573 0.0484
Brugia malayi EGF-like domain containing protein 0.0021 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0089 0.1401 0.14
Mycobacterium tuberculosis Probable lipase LipD 0.0089 0.1401 0.139
Schistosoma mansoni hypothetical protein 0.0022 0.0286 0.0194
Schistosoma mansoni notch 0.0021 0.0253 0.0161
Loa Loa (eye worm) hypothetical protein 0.0014 0.0139 0.0138
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0346 0.0346
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0115 0.0113
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Schistosoma mansoni notch 0.0021 0.0253 0.0161
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0345
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0346 0.0254
Loa Loa (eye worm) isocitrate dehydrogenase 0.0012 0.0104 0.0102
Echinococcus granulosus snurportin 1 0.0192 0.3141 0.314
Plasmodium vivax importin-beta 2, putative 0.0018 0.0211 0.0826
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.0346 0.0254
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0013 0.0131 0.021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.06 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0976 0.0975
Echinococcus granulosus transmembrane protease serine 3 0.06 1 1
Mycobacterium ulcerans hypothetical protein 0.0016 0.0183 0.007
Brugia malayi MH1 domain containing protein 0.0011 0.0094 0.0094
Echinococcus multilocularis neurogenic locus notch protein 0.0021 0.0253 0.0252
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.0139 0.0138
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.06 1 1
Brugia malayi EGF-like domain containing protein 0.0021 0.0253 0.0253
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0089 0.1401 0.1319
Echinococcus granulosus cpg binding protein 0.0019 0.0227 0.0226
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Mycobacterium tuberculosis Probable lipase LipE 0.0089 0.1401 0.139
Onchocerca volvulus 0.0021 0.0253 0.014
Schistosoma mansoni hypothetical protein 0.0021 0.0253 0.0161
Brugia malayi Animal haem peroxidase family protein 0.0063 0.0976 0.0976
Schistosoma mansoni hypothetical protein 0.0255 0.4204 0.4149
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Onchocerca volvulus Peroxidase homolog 0.0063 0.0976 0.0872
Onchocerca volvulus 0.06 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0346 0.0345
Onchocerca volvulus 0.06 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0016 0.0183 0.007
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0012 0.0115 0.0113
Echinococcus granulosus peroxidasin 0.0063 0.0976 0.0975
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Echinococcus multilocularis protein jagged 2 0.0021 0.0253 0.0252
Echinococcus granulosus protein jagged 2 0.0021 0.0253 0.0252
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0346 0.0345
Schistosoma mansoni tar DNA-binding protein 0.004 0.0573 0.0484
Echinococcus multilocularis thyroid hormone receptor alpha 0.0026 0.0346 0.0345
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0032 0.0438 0.0347
Echinococcus granulosus protein jagged 1 0.0021 0.0253 0.0252
Schistosoma mansoni tar DNA-binding protein 0.004 0.0573 0.0484
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.0346 0.0345
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0346 0.0346
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0346 0.0234
Trichomonas vaginalis D-aminoacylase, putative 0.0089 0.1401 1
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.0976 0.0975
Brugia malayi conserved hypotetical protein 0.0012 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.06 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.06 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0089 0.1401 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.0139 0.0138
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0012 0.0104 0.0102
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0346 0.0346
Schistosoma mansoni septate junction protein 0.0021 0.0253 0.0161
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0016 0.0183 0.0086
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.0346 0.0345
Schistosoma mansoni peroxidasin 0.0063 0.0976 0.0891
Loa Loa (eye worm) hypothetical protein 0.0063 0.0976 0.0975
Echinococcus granulosus smad 0.0011 0.0094 0.0093
Brugia malayi notch-like transmembrane receptor 0.0021 0.0253 0.0253
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.0346 0.0345
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.0346 0.0345
Brugia malayi MH2 domain containing protein 0.0011 0.0094 0.0094
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0022 0.0286 0.0285
Echinococcus granulosus protein jagged 1 0.0021 0.0253 0.0252
Onchocerca volvulus Putative cubilin 0.0021 0.0253 0.014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0113 0.0112
Brugia malayi MH2 domain containing protein 0.0162 0.264 0.264
Brugia malayi nuclear hormone receptor family member odr-7 0.0012 0.0115 0.0115
Onchocerca volvulus 0.0063 0.0976 0.0872
Echinococcus granulosus importin subunit beta 1 0.0018 0.0211 0.021
Echinococcus multilocularis snurportin 1 0.0192 0.3141 0.314
Trichomonas vaginalis D-aminoacylase, putative 0.0089 0.1401 1
Toxoplasma gondii ABC1 family protein 0.0089 0.1401 1
Mycobacterium ulcerans hypothetical protein 0.06 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0089 0.1401 1
Schistosoma mansoni cercarial elastase (S01 family) 0.06 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0032 0.0438 0.0438
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.0346 0.0254
Loa Loa (eye worm) hypothetical protein 0.0063 0.0976 0.0975
Loa Loa (eye worm) hypothetical protein 0.0012 0.0115 0.0113
Loa Loa (eye worm) hypothetical protein 0.0063 0.0976 0.0975
Brugia malayi Trypsin family protein 0.06 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.0346 0.0345
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.06 1 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0012 0.0104 0.0002
Schistosoma mansoni hypothetical protein 0.0021 0.0253 0.0161
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0346 0.0254
Loa Loa (eye worm) Smad1 0.0011 0.0094 0.0093
Schistosoma mansoni tar DNA-binding protein 0.004 0.0573 0.0484
Loa Loa (eye worm) hypothetical protein 0.0016 0.0183 0.0182
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0346 0.0346
Echinococcus multilocularis glycoprotein Antigen 5 0.06 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0113 0.0112
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.06 1 1
Schistosoma mansoni hypothetical protein 0.0021 0.0253 0.0161
Echinococcus multilocularis slit 2 protein 0.0021 0.0253 0.0252
Schistosoma mansoni notch 0.0021 0.0253 0.0161
Onchocerca volvulus Chorion peroxidase homolog 0.0063 0.0976 0.0872
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0346 0.0345
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0115 0.0115
Brugia malayi CXXC zinc finger family protein 0.0018 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0345
Loa Loa (eye worm) blistered cuticle protein 3 0.0063 0.0976 0.0975
Loa Loa (eye worm) hypothetical protein 0.0014 0.0139 0.0138
Mycobacterium leprae conserved hypothetical protein 0.0089 0.1401 1
Onchocerca volvulus 0.06 1 1
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0346 0.0254
Brugia malayi Animal haem peroxidase family protein 0.0063 0.0976 0.0976
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0346 0.0346
Echinococcus multilocularis Mastin 0.06 1 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0089 0.1401 0.14
Echinococcus granulosus neurogenic locus notch protein 0.0021 0.0253 0.0252
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.06 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Brugia malayi steroid hormone receptor 0.0026 0.0346 0.0346
Echinococcus multilocularis cpg binding protein 0.0019 0.0227 0.0226
Loa Loa (eye worm) hypothetical protein 0.0063 0.0976 0.0975
Loa Loa (eye worm) DR-78 0.0012 0.0115 0.0113
Echinococcus granulosus neural cadherin 0.0021 0.0253 0.0252
Entamoeba histolytica acyl-CoA synthetase, putative 0.0016 0.0183 1
Brugia malayi MH1 domain containing protein 0.0011 0.0094 0.0094
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0253 0.0253
Schistosoma mansoni notch 0.0021 0.0253 0.0161
Brugia malayi Cadherin domain containing protein 0.0021 0.0253 0.0253
Schistosoma mansoni hypothetical protein 0.0192 0.3141 0.3076
Brugia malayi RNA binding protein 0.004 0.0573 0.0573
Loa Loa (eye worm) hypothetical protein 0.0063 0.0976 0.0975
Onchocerca volvulus Neurogenic locus notch homolog 0.0021 0.0253 0.014
Onchocerca volvulus 0.0063 0.0976 0.0872
Schistosoma mansoni nuclear receptor nhr-48 0.0012 0.0115 0.0021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0115 0.0113
Entamoeba histolytica acyl-CoA synthetase, putative 0.0016 0.0183 1
Toxoplasma gondii EGF family domain-containing protein 0.0021 0.0253 0.1153
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0115 0.0021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0032 0.0438 0.0347
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0015 0.0153 0.0179
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0396 0.2256
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0346 0.0346
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0013 0.0131 0.021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0115 0.0113
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Loa Loa (eye worm) hypothetical protein 0.0063 0.0976 0.0975
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.0976 0.0975
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.0346 0.0345
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0127 0.0126
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0089 0.1401 0.139
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.0346 0.0254
Schistosoma mansoni cercarial elastase (S01 family) 0.06 1 1
Brugia malayi Latrophilin receptor protein 2 0.0022 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Brugia malayi Importin beta-1 subunit 0.0018 0.0211 0.0211
Brugia malayi nuclear receptor NHR-88 0.0012 0.0115 0.0115
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0346 0.0345
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.0346 0.0254
Echinococcus multilocularis neurogenic locus notch protein 4 0.0021 0.0253 0.0252
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0183 0.007
Echinococcus granulosus FTZ F1 alpha 0.0026 0.0346 0.0345
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0013 0.0131 0.021
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.0346 0.0254
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0021 0.0253 0.0161
Echinococcus granulosus thyroid hormone receptor alpha 0.0012 0.0115 0.0113
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0012 0.0113 0.5
Brugia malayi hypothetical protein 0.0014 0.0139 0.0139
Onchocerca volvulus 0.06 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0115 0.0113
Echinococcus granulosus neurogenic locus notch protein 0.0021 0.0253 0.0252
Leishmania major 4-coumarate:coa ligase-like protein 0.0016 0.0183 0.0611
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0063 0.0976 0.0975
Echinococcus multilocularis fat cadherin tumor suppressor 0.0021 0.0253 0.0252
Schistosoma mansoni hypothetical protein 0.0021 0.0253 0.0161
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Echinococcus granulosus enteropeptidase 0.06 1 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0011 0.0094 0.0093
Brugia malayi MH1 domain containing protein 0.0006 0.0011 0.0011
Brugia malayi Animal haem peroxidase family protein 0.0063 0.0976 0.0976
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0032 0.0438 0.0437
Brugia malayi hypothetical protein 0.0029 0.0396 0.0396
Loa Loa (eye worm) notch protein 0.0021 0.0253 0.0252
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0012 0.0115 0.0113
Brugia malayi ecdysone receptor 0.0012 0.0115 0.0115
Echinococcus granulosus tar DNA binding protein 0.004 0.0573 0.0572
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0346 0.0345
Echinococcus granulosus mothers against decapentaplegic 5 0.0011 0.0094 0.0093
Schistosoma mansoni slit 0.0021 0.0253 0.0161
Brugia malayi EGF-like domain containing protein 0.0021 0.0253 0.0253
Echinococcus multilocularis neurogenic locus notch protein 0.0021 0.0253 0.0252
Loa Loa (eye worm) hypothetical protein 0.0012 0.0115 0.0113
Brugia malayi nuclear receptor RXR 0.0012 0.0115 0.0115
Brugia malayi GCC2 and GCC3 family protein 0.0021 0.0253 0.0253
Brugia malayi nuclear hormone receptor 0.0026 0.0346 0.0346
Echinococcus granulosus slit 2 protein 0.0021 0.0253 0.0252
Loa Loa (eye worm) hypothetical protein 0.0022 0.0286 0.0285
Plasmodium falciparum importin beta, putative 0.0018 0.0211 0.3662
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0127 0.0126
Schistosoma mansoni hypothetical protein 0.0021 0.0253 0.0161
Onchocerca volvulus 0.0089 0.1401 0.1301
Loa Loa (eye worm) hypothetical protein 0.0012 0.0115 0.0113
Brugia malayi isocitrate dehydrogenase 0.0012 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0016 0.0183 0.0182
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.0139 0.0046
Onchocerca volvulus 0.0021 0.0253 0.014
Echinococcus granulosus delta-like protein 1 0.0021 0.0253 0.0252
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.0346 0.0345
Mycobacterium tuberculosis Conserved protein 0.0089 0.1401 0.139
Echinococcus multilocularis fibropellin Ia 0.0021 0.0253 0.0252
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0115 0.0113
Loa Loa (eye worm) hypothetical protein 0.0012 0.0113 0.0112
Schistosoma mansoni cercarial elastase (S01 family) 0.06 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0113 0.0112
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0032 0.0438 0.0437
Brugia malayi nuclear hormone receptor family member nhr-6 0.0012 0.0115 0.0115
Brugia malayi Peroxidasin 0.0063 0.0976 0.0976
Loa Loa (eye worm) hypothetical protein 0.0071 0.1103 0.1102
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0104 0.0102
Mycobacterium tuberculosis Conserved protein 0.0089 0.1401 0.139
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0252
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0012 0.0115 0.0113
Schistosoma mansoni cell polarity protein 0.0021 0.0253 0.0161
Brugia malayi RNA, U transporter 1 0.0051 0.0769 0.0769
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0139 0.0046
Schistosoma mansoni laminin gamma-3 chain 0.0021 0.0253 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0346 0.0346
Schistosoma mansoni peroxidasin 0.0063 0.0976 0.0891
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0022 0.0286 0.0285
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0396 0.2256
Echinococcus multilocularis mothers against decapentaplegic 5 0.0011 0.0094 0.0093
Loa Loa (eye worm) hypothetical protein 0.0014 0.0139 0.0138
Echinococcus multilocularis transmembrane protease serine 3 0.06 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0016 0.0183 0.0611
Loa Loa (eye worm) hypothetical protein 0.06 1 1
Echinococcus granulosus Mastin 0.06 1 1
Onchocerca volvulus 0.0089 0.1401 0.1301
Onchocerca volvulus 0.0021 0.0253 0.014
Echinococcus multilocularis importin subunit beta 1 0.0018 0.0211 0.021
Onchocerca volvulus 0.0089 0.1401 0.1301

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.085 uM Inhibition of human COX2 ChEMBL. 20709553
IC50 (binding) = 15.8 uM Inhibition of human COX1 ChEMBL. 20709553

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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