Detailed information for compound 1464407

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 311.171 | Formula: C14H15BrO3
  • H donors: 1 H acceptors: 2 LogP: 4.04 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=CCOc1ccc(cc1Br)/C=C/C(=O)O)C
  • InChi: 1S/C14H15BrO3/c1-10(2)7-8-18-13-5-3-11(9-12(13)15)4-6-14(16)17/h3-7,9H,8H2,1-2H3,(H,16,17)/b6-4+
  • InChiKey: KGPSDHGZMFLGAO-GQCTYLIASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus intermediate filament protein 0.0031 0.0217 0.0202
Trypanosoma cruzi cystathionine beta-synthase, putative 0.0156 0.2053 0.5017
Entamoeba histolytica threonine dehydratase, putative 0.0039 0.0329 0.0603
Loa Loa (eye worm) RNA binding protein 0.0063 0.0685 0.0683
Brugia malayi hypothetical protein 0.0018 0.0015 0.0012
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0372 0.1487
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0685 0.0671
Trichomonas vaginalis cysteine synthase, putative 0.0156 0.2053 0.3913
Echinococcus granulosus aldo keto reductase 0.0031 0.021 0.0195
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.021 0.0195
Trichomonas vaginalis cysteine synthase, putative 0.0156 0.2053 0.3913
Loa Loa (eye worm) hypothetical protein 0.0033 0.0239 0.0236
Brugia malayi mbt repeat family protein 0.0046 0.0438 0.0435
Brugia malayi beta-lactamase family protein 0.0042 0.0372 0.0369
Loa Loa (eye worm) hypothetical protein 0.0042 0.0372 0.0369
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0685 0.0671
Brugia malayi intermediate filament protein 0.0031 0.0217 0.0214
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.2032 0.5232
Mycobacterium leprae Probable lipase LipE 0.0042 0.0372 0.1487
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0015 0.0012
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0647 0.0633
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0363 0.0857
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0372 0.0466
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.4077 1
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0156 0.2053 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.021 0.0373
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.07 0.0698
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0217 0.0214
Mycobacterium ulcerans beta-lactamase 0.0042 0.0372 0.0323
Onchocerca volvulus 0.0371 0.5223 1
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0018 0.0015 0.0012
Trypanosoma brucei unspecified product 0.0052 0.0525 0.1255
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.01 0.1233 0.2997
Trypanosoma brucei DNA polymerase IV, putative 0.0052 0.0525 0.1255
Giardia lamblia Aldose reductase 0.0031 0.021 0.0373
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.07 0.1686
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.0619 0.116
Echinococcus granulosus tar DNA binding protein 0.0063 0.0685 0.0671
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0286 0.0667
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0372 0.0323
Onchocerca volvulus 0.0031 0.021 0.0373
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0333 0.0783
Trichomonas vaginalis cysteine synthase, putative 0.0156 0.2053 0.3913
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0267 0.0252
Leishmania major serine-threonine dehydratase, putative 0.0039 0.0329 0.0773
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0015 0.0012
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.021 0.0195
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.021 0.0373
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0267 0.0252
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0297 0.025
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.07 0.1315
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0371 0.5223 1
Mycobacterium tuberculosis Conserved protein 0.0042 0.0372 0.0466
Trypanosoma cruzi serine-threonine dehydratase, putative 0.0039 0.0329 0.0773
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0267 0.0252
Onchocerca volvulus 0.0031 0.0217 0.0388
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.021 0.0195
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Brugia malayi hypothetical protein 0.0018 0.0015 0.0012
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.021 0.0195
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0685 0.0671
Giardia lamblia Threonine dehydratase lateral transfer candidate 0.0039 0.0329 0.0603
Loa Loa (eye worm) hypothetical protein 0.0031 0.0217 0.0214
Trypanosoma cruzi threonine synthase, putative 0.0039 0.0329 0.0773
Loa Loa (eye worm) oxidoreductase 0.0031 0.021 0.0207
Onchocerca volvulus 0.0031 0.0217 0.0388
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0239 0.0236
Schistosoma mansoni aldo-keto reductase 0.0031 0.021 0.0195
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0114 0.1441 0.351
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0597 0.0594
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.1441 0.351
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0031 0.021 0.0479
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.099 0.2241
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.021 0.0195
Trypanosoma brucei trypanothione reductase 0.0037 0.0297 0.0693
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0619 0.1487
Schistosoma mansoni aldo-keto reductase 0.0031 0.021 0.0195
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0015 0.0012
Mycobacterium ulcerans cysteine synthase 0.0039 0.0329 0.0239
Brugia malayi RNA binding protein 0.0063 0.0685 0.0683
Schistosoma mansoni hypothetical protein 0.0282 0.3905 0.3895
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.021 0.0373
Onchocerca volvulus 0.0275 0.381 0.7286
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0183 0.0413
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0647 0.1255
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0647 0.0633
Brugia malayi jmjC domain containing protein 0.0057 0.0597 0.0594
Brugia malayi Thioredoxin reductase 0.0037 0.0297 0.0294
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0015 0.0012
Plasmodium falciparum thioredoxin reductase 0.0037 0.0297 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0619 0.1487
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.01 0.1233 0.2997
Echinococcus multilocularis aldo keto reductase 0.0031 0.021 0.0195
Mycobacterium ulcerans lipase LipD 0.0042 0.0372 0.0323
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0304 0.0289
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.021 0.0373
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0496 0.1184
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0372 0.0878
Trypanosoma brucei threonine synthase, putative 0.0039 0.0329 0.0773
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0015 0.0012
Leishmania major DNA polymerase eta, putative 0.0033 0.0239 0.055
Giardia lamblia DINP protein human, muc B family 0.0039 0.0333 0.061
Trichomonas vaginalis esterase, putative 0.0042 0.0372 0.0685
Echinococcus multilocularis musashi 0.0031 0.0217 0.0202
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0372 0.0685
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0533 0.0518
Loa Loa (eye worm) oxidoreductase 0.0031 0.021 0.0207
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0647 0.1555
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0297 0.0693
Giardia lamblia Aldose reductase 0.0031 0.021 0.0373
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0597 0.0583
Loa Loa (eye worm) oxidoreductase 0.0031 0.021 0.0207
Loa Loa (eye worm) beta-lactamase 0.0042 0.0372 0.0369
Brugia malayi Pre-SET motif family protein 0.0035 0.0267 0.0264
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.021 0.0373
Echinococcus multilocularis lamin 0.0031 0.0217 0.0202
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0183 0.0413
Trypanosoma brucei cystathionine beta-synthase, putative 0.0156 0.2053 0.5017
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0363 0.0857
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0126 0.0272
Echinococcus multilocularis aldo keto reductase 0.0031 0.021 0.0195
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.1128 0.2637
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0242 0.3318 0.3316
Schistosoma mansoni cysteine synthase 0.0156 0.2053 0.2041
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.099 0.2241
Trichomonas vaginalis CMGC family protein kinase 0.01 0.1233 0.2338
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0183 0.2445 0.2434
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.01 0.1233 0.2997
Mycobacterium tuberculosis Conserved protein 0.0042 0.0372 0.0466
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0217 0.0214
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.021 0.0195
Loa Loa (eye worm) hypothetical protein 0.0145 0.1893 0.1891
Schistosoma mansoni threonine dehydratase/deaminase 0.0039 0.0329 0.0315
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0126 0.0612
Echinococcus multilocularis l serine dehydratase:l threonine deaminase 0.0039 0.0329 0.0315
Chlamydia trachomatis tryptophan synthase subunit beta 0.0039 0.0329 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.0372 0.0369
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0372 0.0357
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Brugia malayi Pyridoxal-phosphate dependent enzyme family protein 0.0039 0.0329 0.0327
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.021 0.0373
Brugia malayi Pyridoxal-phosphate dependent enzyme family protein 0.0156 0.2053 0.2051
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.1441 0.351
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0619 0.1487
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0533 0.0518
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.021 0.0373
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Brugia malayi Protein-tyrosine phosphatase 1 0.0018 0.0015 0.0012
Trypanosoma brucei prostaglandin f synthase 0.0031 0.021 0.0479
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0031 0.021 0.0479
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.0619 0.116
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0619 0.0817
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0297 0.6956
Echinococcus granulosus aldo keto reductase 0.0031 0.021 0.0195
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0018 0.0015 0.0012
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0371 0.5223 0.5222
Loa Loa (eye worm) hypothetical protein 0.0031 0.021 0.0207
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0239 0.0224
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.021 0.0195
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0619 0.1487
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.021 0.0195
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.021 0.0195
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0372 0.0685
Brugia malayi hypothetical protein 0.0025 0.0126 0.0123
Echinococcus multilocularis aldehyde reductase 0.0022 0.0078 0.0063
Loa Loa (eye worm) hypothetical protein 0.0031 0.0209 0.0206
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.07 0.0698
Mycobacterium ulcerans cysteine synthase a CysK1 0.0156 0.2053 0.3677
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0372 0.0878
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0372 0.0466
Onchocerca volvulus 0.0042 0.0372 0.0685
Loa Loa (eye worm) hypothetical protein 0.0046 0.0438 0.0435
Brugia malayi glutathione reductase 0.0037 0.0297 0.0294
Loa Loa (eye worm) hypothetical protein 0.0122 0.1554 0.1552
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0183 0.0413
Echinococcus multilocularis dna polymerase kappa 0.0059 0.0619 0.0605
Schistosoma mansoni hypothetical protein 0.0333 0.4668 0.4659
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0239 0.0236
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0031 0.021 0.0666
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0597 0.0583
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Trypanosoma brucei unspecified product 0.0023 0.0089 0.0181
Loa Loa (eye worm) hypothetical protein 0.0035 0.0267 0.0264
Mycobacterium tuberculosis Threonine synthase ThrC (ts) 0.0039 0.0329 0.0344
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0597 0.0583
Entamoeba histolytica threonine dehydratase, putative 0.0039 0.0329 0.0603
Schistosoma mansoni serine/threonine protein kinase 0.01 0.1233 0.1219
Toxoplasma gondii pyridoxal-phosphate dependent superfamily protein 0.0156 0.2053 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1801 0.4396
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0302 0.0287
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.021 0.0195
Onchocerca volvulus 0.0042 0.0372 0.0685
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0333 0.0783
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.07 0.0686
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Trypanosoma cruzi cysteine synthase, putative 0.0156 0.2053 0.5017
Brugia malayi mbt repeat family protein 0.0046 0.0438 0.0435
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0647 0.0633
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0018 0.0015 0.0012
Mycobacterium tuberculosis Probable reductase 0.0084 0.099 0.2241
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.1128 0.2637
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.021 0.0207
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0597 0.0583
Trypanosoma cruzi aldo/keto reductase, putative 0.0031 0.021 0.0479
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0438 0.0423
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.01 0.1233 0.6004
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.099 0.4619
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0372 0.0357
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0372 0.0466
Loa Loa (eye worm) hypothetical protein 0.0042 0.0372 0.0369
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.07 0.1686
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Loa Loa (eye worm) MBCTL1 0.0053 0.0533 0.053
Brugia malayi Protein-tyrosine phosphatase 0.0018 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0685 0.0683
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0371 0.5223 0.5222
Loa Loa (eye worm) glutathione reductase 0.0037 0.0297 0.0294
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.021 0.0373
Mycobacterium ulcerans cysteine synthase B 0.0156 0.2053 0.3677
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0114 0.1441 0.2738
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0533 0.053
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.021 0.0373
Onchocerca volvulus 0.0031 0.021 0.0373
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.021 0.0195
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.021 0.0373
Entamoeba histolytica aldose reductase, putative 0.0031 0.021 0.0373
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.021 0.0195
Leishmania major trypanothione reductase 0.0037 0.0297 0.0693
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0126 0.0272
Echinococcus granulosus lamin 0.0031 0.0217 0.0202
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0018 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.021 0.0373
Leishmania major hypothetical protein, conserved 0.0114 0.1441 0.351
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.021 0.0195
Onchocerca volvulus Huntingtin homolog 0.0122 0.1554 0.2955
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0438 0.0423
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0267 0.1298
Entamoeba histolytica threonine dehydratase, putative 0.0039 0.0329 0.0603
Brugia malayi beta-lactamase 0.0042 0.0372 0.0369
Brugia malayi Pyridoxal-phosphate dependent enzyme family protein 0.0039 0.0329 0.0327
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0372 0.0878
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0183 0.2445 0.2434
Trichomonas vaginalis threonine dehydratase/deaminase, putative 0.0039 0.0329 0.0603
Entamoeba histolytica cysteine synthase A, putative 0.0156 0.2053 0.3913
Mycobacterium leprae PROBABLE CYSTEINE SYNTHASE A CYSK (O-ACETYLSERINE SULFHYDRYLASE A) (O-ACETYLSERINE (THIOL)-LYASE A) (CSASE A) 0.0156 0.2053 1
Mycobacterium tuberculosis Probable lyase 0.0039 0.0329 0.0344
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0696 1 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0533 0.053
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0257 0.3538 0.9556
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0239 0.0224
Trichomonas vaginalis cysteine synthase, putative 0.0156 0.2053 0.3913
Trichomonas vaginalis cysteine synthase, putative 0.0156 0.2053 0.3913
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0597 0.0583
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.1233 0.2997
Trichomonas vaginalis CMGC family protein kinase 0.01 0.1233 0.2338
Leishmania major threonine synthase, putative 0.0039 0.0329 0.0773
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0015 0.0012
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.07 0.1686
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.021 0.0373
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.07 0.1686
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0647 0.0633
Brugia malayi cbs-prov protein 0.0156 0.2053 0.2051
Trypanosoma cruzi serine sulfhydrylase 0.0156 0.2053 0.5017
Trichomonas vaginalis cysteine synthase, putative 0.0039 0.0329 0.0603
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0597 0.0583
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0533 0.0518
Loa Loa (eye worm) hypothetical protein 0.0122 0.1554 0.1552
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0018 0.0015 0.0012
Brugia malayi beta-lactamase family protein 0.0042 0.0372 0.0369
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Trypanosoma cruzi aldo-keto reductase 0.0031 0.021 0.0479
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0267 0.0252
Schistosoma mansoni microtubule-associated protein tau 0.067 0.963 0.9629
Plasmodium falciparum glutathione reductase 0.0037 0.0297 1
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0018 0.0015 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0619 0.1487
Trichomonas vaginalis threonine dehydratase/deaminase, putative 0.0039 0.0329 0.0603
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0372 1
Trichomonas vaginalis set domain proteins, putative 0.0275 0.381 0.7286
Trichomonas vaginalis threonine synthase, putative 0.0156 0.2053 0.3913
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0248 0.0233
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.021 0.0373
Schistosoma mansoni intermediate filament proteins 0.0031 0.0217 0.0202
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0297 0.0294
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0533 0.0518
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0685 0.0671
Toxoplasma gondii ABC1 family protein 0.0042 0.0372 0.1811
Entamoeba histolytica aldose reductase, putative 0.0031 0.021 0.0373
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.021 0.0195
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1801 0.4396
Onchocerca volvulus 0.0031 0.021 0.0373
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0647 0.0872
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0438 0.0423
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0015 0.0012
Toxoplasma gondii hypothetical protein 0.0047 0.0453 0.2205
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0015 0.0012
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0371 0.5223 1
Mycobacterium tuberculosis Cysteine synthase a CysK1 (O-acetylserine sulfhydrylase A) (O-acetylserine (thiol)-lyase A) (CSASE A) 0.0156 0.2053 0.5293
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.4077 1
Mycobacterium ulcerans threonine dehydratase 0.0039 0.0329 0.0239
Onchocerca volvulus Serine racemase homolog 0.0039 0.0329 0.0603
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0015 0.0012
Brugia malayi TAR-binding protein 0.0063 0.0685 0.0683
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Echinococcus multilocularis aldo keto reductase 0.0031 0.021 0.0195
Echinococcus multilocularis aldo keto reductase 0.0031 0.021 0.0195
Toxoplasma gondii CBS family protein 0.0156 0.2053 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0239 0.0224
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0114 0.1441 0.2738
Mycobacterium ulcerans tryptophan synthase subunit beta 0.0039 0.0329 0.0239
Entamoeba histolytica cysteine synthase A, putative 0.0156 0.2053 0.3913
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0217 0.0214
Mycobacterium leprae Probable tryptophan synthase, beta subunit TrpB 0.0039 0.0329 0.1272
Echinococcus granulosus mitogen activated protein kinase 0.01 0.1233 0.1219
Echinococcus granulosus geminin 0.0333 0.4668 0.4659
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.4077 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0619 0.1487
Plasmodium vivax SET domain protein, putative 0.0035 0.0267 0.5723
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0267 0.0252
Schistosoma mansoni lamin 0.0031 0.0217 0.0202
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Echinococcus granulosus l serine dehydratase:l threonine deaminase 0.0039 0.0329 0.0315
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.099 0.2241
Echinococcus granulosus microtubule associated protein 2 0.067 0.963 0.9629
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.021 0.0373
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0696 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0372 0.0685
Leishmania major hypothetical protein, conserved 0.0025 0.0126 0.0272
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.021 0.0373
Brugia malayi Pre-SET motif family protein 0.0242 0.3318 0.3316
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.021 0.0195
Loa Loa (eye worm) cbs-prov protein 0.0156 0.2053 0.2051
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0239 0.0224
Trichomonas vaginalis CMGC family protein kinase 0.01 0.1233 0.2338
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0302 0.0287
Echinococcus granulosus hypothetical protein 0.0031 0.021 0.0195
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0619 0.1487
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.021 0.0195
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0685 0.0671
Schistosoma mansoni cysteine synthase 0.0156 0.2053 0.2041
Trichomonas vaginalis threonine synthase, putative 0.0156 0.2053 0.3913
Mycobacterium leprae Probable threonine dehydratase IlvA 0.0039 0.0329 0.1272
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0015 0.0012
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0647 0.0872
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0619 0.1487
Onchocerca volvulus 0.0031 0.021 0.0373
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0239 0.0236
Leishmania major aldo-keto reductase-like protein 0.0031 0.021 0.0479
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0239 0.0429
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.021 0.0373
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0372 0.0466
Trypanosoma brucei aldo-keto reductase, putative 0.0031 0.021 0.0479
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.021 0.0195
Echinococcus multilocularis microtubule associated protein 2 0.067 0.963 0.9629
Mycobacterium ulcerans hypothetical protein 0.0155 0.2032 0.3635
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.021 0.0373
Onchocerca volvulus 0.0042 0.0372 0.0685
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0015 0.0012
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.07 0.0686
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0371 0.5223 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0647 0.3151
Loa Loa (eye worm) protein tyrosine phosphatase 0.0018 0.0015 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0619 0.1487
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0619 0.1487
Trypanosoma cruzi serine-threonine dehydratase, putative 0.0039 0.0329 0.0773
Mycobacterium tuberculosis Conserved protein 0.0042 0.0372 0.0466
Leishmania major hypothetical protein, conserved 0.0042 0.0372 0.0878
Echinococcus multilocularis mitogen activated protein kinase 0.01 0.1233 0.1219
Schistosoma mansoni threonine dehydratase 0.0039 0.0329 0.0315
Mycobacterium tuberculosis Tryptophan synthase, beta subunit TrpB 0.0039 0.0329 0.0344
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.099 0.2241
Brugia malayi hypothetical protein 0.0018 0.0015 0.0012
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0372 0.0685
Trichomonas vaginalis CMGC family protein kinase 0.01 0.1233 0.2338
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0619 0.1487
Echinococcus granulosus muscleblind protein 0.0145 0.1893 0.1881
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0267 0.0252
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0156 0.2053 0.5293
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0372 0.0369
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0371 0.5223 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0286 0.0667
Echinococcus multilocularis geminin 0.0333 0.4668 0.4659
Loa Loa (eye worm) hypothetical protein 0.0145 0.1893 0.1891
Leishmania major cysteine synthase 0.0156 0.2053 0.5017
Leishmania major DNA polymerase kappa, putative 0.0039 0.0333 0.0783
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.01 0.1233 0.2997
Trypanosoma cruzi threonine synthase, putative 0.0039 0.0329 0.0773
Schistosoma mansoni DNA polymerase eta 0.0033 0.0239 0.0224
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0597 0.0583
Trypanosoma cruzi cystathionine beta-synthase 0.0156 0.2053 0.5017
Brugia malayi Muscleblind-like protein 0.0145 0.1893 0.1891
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0685 0.0683
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1893 0.1881
Entamoeba histolytica aldose reductase, putative 0.0031 0.021 0.0373
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0619 0.1487
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0372 0.0357
Giardia lamblia Kinase, CMGC MAPK 0.01 0.1233 0.2338
Trypanosoma cruzi serine-threonine dehydratase, putative 0.0039 0.0329 0.0773
Echinococcus granulosus aldo keto reductase 0.0031 0.021 0.0195
Onchocerca volvulus Huntingtin homolog 0.0122 0.1554 0.2955
Echinococcus multilocularis muscleblind protein 0.0145 0.1893 0.1881
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0371 0.5223 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0371 0.5223 1
Trypanosoma cruzi serine sulfhydrylase 0.0156 0.2053 0.5017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0619 0.1487
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.1128 0.5316
Trypanosoma cruzi serine sulfhydrylase 0.0156 0.2053 0.5017
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0438 0.0423
Loa Loa (eye worm) hypothetical protein 0.0042 0.0372 0.0369
Onchocerca volvulus 0.0039 0.0329 0.0603
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Mycobacterium tuberculosis Probable threonine dehydratase IlvA 0.0039 0.0329 0.0344
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0619 0.1487
Trypanosoma cruzi cysteine synthase, putative 0.0156 0.2053 0.5017
Echinococcus granulosus mitogen activated protein kinase 3 0.01 0.1233 0.1219
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.021 0.0207
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.07 0.0686
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0304 0.0289
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0647 0.0872
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0372 0.0466
Echinococcus multilocularis dna polymerase eta 0.0033 0.0239 0.0224
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.021 0.0195
Echinococcus multilocularis mitogen activated protein kinase 3 0.01 0.1233 0.1219
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0619 0.1487
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0015 0.0012
Trypanosoma cruzi cystathionine beta-synthase 0.0156 0.2053 0.5017
Leishmania major cystathionine beta-synthase 0.0156 0.2053 0.5017
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0685 0.0671
Toxoplasma gondii O-acetylserine (thiol) lyase 2, putative 0.0039 0.0329 0.1604
Trichomonas vaginalis cysteine synthase, putative 0.0156 0.2053 0.3913
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0438 0.0435
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0372 0.0357
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.021 0.0373
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.099 0.2241
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0438 0.0423
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0363 0.0857
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0372 0.0466
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Brugia malayi jmjC domain containing protein 0.0057 0.0597 0.0594
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0371 0.5223 1
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0438 0.0423
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0372 0.0369
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.4077 1
Entamoeba histolytica threonine dehydratase catabolic, putative 0.0039 0.0329 0.0603
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Echinococcus multilocularis lamin dm0 0.0031 0.0217 0.0202
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0696 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Trypanosoma cruzi cystathionine beta-synthase, putative 0.0156 0.2053 0.5017
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0126 0.0272
Leishmania major prostaglandin f synthase, putative 0.0031 0.021 0.0479
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0619 0.0817
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0239 0.055
Trypanosoma cruzi cystathionine beta-synthase, putative 0.0156 0.2053 0.5017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0042 0.0372 0.0369
Mycobacterium leprae PROBABLE THREONINE SYNTHASE THRC 0.0039 0.0329 0.1272
Trypanosoma brucei protein kinase, putative 0.01 0.1233 0.2997
Schistosoma mansoni hypothetical protein 0.0333 0.4668 0.4659
Echinococcus granulosus aldehyde reductase 0.0022 0.0078 0.0063
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0685 0.0683
Onchocerca volvulus 0.0031 0.021 0.0373
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0372 0.0685
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.021 0.0207
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0333 0.0355
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.1128 0.2637
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.1801 0.4396
Brugia malayi hypothetical protein 0.0122 0.1554 0.1552
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.01 0.1233 0.2997
Schistosoma mansoni lamin 0.0031 0.0217 0.0202
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0267 0.3692 1
Entamoeba histolytica cysteine synthase A, putative 0.0156 0.2053 0.3913
Brugia malayi hypothetical protein 0.0018 0.0015 0.0012
Plasmodium vivax glutathione reductase, putative 0.0037 0.0297 0.6956
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0438 0.0423
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0015 0.0012
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0239 0.055
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.021 0.0195
Mycobacterium ulcerans cystathionine beta-synthase 0.0156 0.2053 0.3677
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.021 0.0207
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Brugia malayi hypothetical protein 0.0018 0.0015 0.0012
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0012
Brugia malayi Protein-tyrosine phosphatase 0.0018 0.0015 0.0012
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Onchocerca volvulus 0.0046 0.0438 0.0812
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0015 0.0012
Trichomonas vaginalis cysteine synthase, putative 0.0039 0.0329 0.0603
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0533 0.0518
Loa Loa (eye worm) oxidoreductase 0.0031 0.021 0.0207
Onchocerca volvulus 0.0031 0.021 0.0373
Trichomonas vaginalis threonine dehydratase/deaminase, putative 0.0039 0.0329 0.0603
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0363 0.0857
Loa Loa (eye worm) oxidoreductase 0.0031 0.021 0.0207
Onchocerca volvulus 0.0035 0.0267 0.0482
Brugia malayi polk-prov protein 0.0036 0.0286 0.0283
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0372 0.0323
Loa Loa (eye worm) hypothetical protein 0.0025 0.0126 0.0123
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0371 0.5223 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.01 0.1233 0.123
Trypanosoma cruzi cystathionine beta-synthase 0.0156 0.2053 0.5017
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0372 0.0466
Echinococcus granulosus lamin dm0 0.0031 0.0217 0.0202
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0371 0.5223 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Brugia malayi MAP kinase sur-1 0.01 0.1233 0.123
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.1233 0.2997
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0283
Echinococcus granulosus dna polymerase eta 0.0033 0.0239 0.0224
Trichomonas vaginalis threonine dehydratase/deaminase, putative 0.0039 0.0329 0.0603
Toxoplasma gondii thioredoxin reductase 0.0037 0.0297 0.1446
Mycobacterium ulcerans threonine synthase 0.0039 0.0329 0.0239
Loa Loa (eye worm) hypothetical protein 0.0042 0.0372 0.0369
Trypanosoma cruzi serine sulfhydrylase 0.0156 0.2053 0.5017
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0239 0.0084
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0696 1 1
Mycobacterium tuberculosis Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B) 0.0156 0.2053 0.5293
Schistosoma mansoni pol-related 0.0031 0.021 0.0195
Trypanosoma brucei unspecified product 0.0023 0.0089 0.0181
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.021 0.0195
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0438 0.0812
Echinococcus granulosus dna polymerase kappa 0.0059 0.0619 0.0605
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0267 0.0252
Mycobacterium ulcerans hypothetical protein 0.0042 0.0372 0.0323
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0371 0.5223 1
Toxoplasma gondii aldose reductase, putative 0.0031 0.021 0.1021
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0015 0.0012
Loa Loa (eye worm) pyridoxal-phosphate dependent enzyme family protein 0.0039 0.0329 0.0327

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 19 % Antiinflammatory activity in CD1 mouse assessed as inhibition of croton oil-induced ear edema at 0.3 umol administered topically per cm'2 of ear relative to control ChEMBL. 21167711

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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