Detailed information for compound 1464413

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 382.37 | Formula: C19H18N4O5
  • H donors: 0 H acceptors: 4 LogP: 2.16 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(nc1)c1ccc(cc1)CO[C@@H]1COc2n(C1)cc(n2)[N+](=O)[O-]
  • InChi: 1S/C19H18N4O5/c1-26-15-6-7-17(20-8-15)14-4-2-13(3-5-14)11-27-16-9-22-10-18(23(24)25)21-19(22)28-12-16/h2-8,10,16H,9,11-12H2,1H3/t16-/m0/s1
  • InChiKey: VXGYMOISCBAESE-INIZCTEOSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0018 0.0035 0.0035
Onchocerca volvulus 0.0046 0.0457 0.0812
Echinococcus granulosus protein tyrosine phosphatase n9 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0369 0.5233 1
Brugia malayi RNA binding protein 0.0063 0.0704 0.0704
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0018 0.0035 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0213 0.0213
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0035 0.0035
Schistosoma mansoni cysteine synthase 0.0155 0.2068 0.2068
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.4089 1
Leishmania major trypanothione reductase 0.0037 0.0316 0.0773
Brugia malayi Thioredoxin reductase 0.0037 0.0316 0.0316
Brugia malayi Protein-tyrosine phosphatase 1 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0145 0.0355
Trichomonas vaginalis cysteine synthase, putative 0.0039 0.0348 0.0603
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0255 0.3551 1
Trichomonas vaginalis threonine synthase, putative 0.0155 0.2068 0.3911
Entamoeba histolytica aldose reductase, putative 0.0031 0.0229 0.0373
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0035 0.0035
Onchocerca volvulus 0.0026 0.0161 0.0242
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.1817 0.4444
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0457 0.0457
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0665 0.0872
Onchocerca volvulus 0.0031 0.0229 0.0373
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0052 0.0552 0.0552
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0018 0.0035 0.0035
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0229 0.0229
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0704 0.0704
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0382 0.0935
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.9631 0.9631
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0692 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0382 0.0935
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0018 0.0035 0.0035
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.0035 0.0086
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0083 0.1008 0.2346
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0155 0.2068 0.5537
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.01 0.125 0.3057
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0229 0.0373
Echinococcus granulosus aldo keto reductase 0.0031 0.0229 0.0229
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0145 0.0355
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.2824 0.2824
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0145 0.0355
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0035 0.0035
Echinococcus multilocularis lamin 0.0026 0.0161 0.0161
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0035 0.0035
Trichomonas vaginalis cysteine synthase, putative 0.0155 0.2068 0.3911
Echinococcus multilocularis geminin 0.0332 0.4678 0.4678
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.01 0.125 0.3057
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0316 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Trichomonas vaginalis DNA polymerase eta, putative 0.0058 0.0638 0.116
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.4089 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0229 0.0373
Leishmania major aldo-keto reductase-like protein 0.0031 0.0229 0.056
Trypanosoma brucei cystathionine beta-synthase, putative 0.0155 0.2068 0.5057
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0258 0.0088
Trichomonas vaginalis CMGC family protein kinase 0.01 0.125 0.2337
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0018 0.0035 0.0035
Trypanosoma brucei unspecified product 0.0023 0.0109 0.0266
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0258 0.0258
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0035 0.0035
Echinococcus granulosus aldo keto reductase 0.0031 0.0229 0.0229
Trypanosoma brucei aldo-keto reductase, putative 0.0031 0.0229 0.056
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0035 0.0035
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0035 0.0035
Echinococcus granulosus muscleblind protein 0.0144 0.1909 0.1909
Trypanosoma brucei unspecified product 0.0023 0.0109 0.0266
Echinococcus granulosus microtubule associated protein 2 0.0667 0.9631 0.9631
Schistosoma mansoni threonine dehydratase 0.0039 0.0348 0.0348
Leishmania major prostaglandin f synthase, putative 0.0031 0.0229 0.056
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.0035 0.0086
Entamoeba histolytica threonine dehydratase, putative 0.0039 0.0348 0.0603
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0213 0.0213
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0719 0.0719
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0369 0.5233 1
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0018 0.0035 0.0035
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0704 0.0704
Trypanosoma cruzi cystathionine beta-synthase 0.0155 0.2068 0.5057
Mycobacterium leprae PROBABLE CYSTEINE SYNTHASE A CYSK (O-ACETYLSERINE SULFHYDRYLASE A) (O-ACETYLSERINE (THIOL)-LYASE A) (CSASE A) 0.0155 0.2068 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0018 0.0035 0.0035
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0035 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0638 0.156
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0018 0.0035 0.0035
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.0035 0.0035
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0018 0.0035 0.0035
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0229 0.0229
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0638 0.156
Trypanosoma brucei prostaglandin f synthase 0.0031 0.0229 0.056
Schistosoma mansoni lamin 0.0026 0.0161 0.0161
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0229 0.0229
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0018 0.0035 0.0035
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0665 0.3217
Echinococcus multilocularis muscleblind protein 1 0.0144 0.1909 0.1909
Schistosoma mansoni hypothetical protein 0.0332 0.4678 0.4678
Entamoeba histolytica cysteine synthase A, putative 0.0155 0.2068 0.3911
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0258 0.0632
Loa Loa (eye worm) oxidoreductase 0.0031 0.0229 0.0229
Trichomonas vaginalis cysteine synthase, putative 0.0155 0.2068 0.3911
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0369 0.5233 1
Trypanosoma cruzi aldo-keto reductase 0.0031 0.0229 0.056
Trichomonas vaginalis cysteine synthase, putative 0.0039 0.0348 0.0603
Echinococcus multilocularis muscleblind protein 0.0144 0.1909 0.1909
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0704 0.0704
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0638 0.156
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0145 0.0702
Trichomonas vaginalis CMGC family protein kinase 0.01 0.125 0.2337
Mycobacterium tuberculosis Threonine synthase ThrC (ts) 0.0039 0.0348 0.0359
Schistosoma mansoni DNA polymerase eta 0.0033 0.0258 0.0258
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.125 0.3057
Onchocerca volvulus 0.0031 0.0229 0.0373
Brugia malayi jmjC domain containing protein 0.0057 0.0616 0.0616
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0229 0.0373
Mycobacterium ulcerans cysteine synthase B 0.0155 0.2068 0.3675
Loa Loa (eye worm) hypothetical protein 0.0144 0.1909 0.1909
Giardia lamblia Threonine dehydratase lateral transfer candidate 0.0039 0.0348 0.0603
Trypanosoma brucei threonine synthase, putative 0.0039 0.0348 0.0852
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0638 0.156
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0035 0.0035
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0665 0.1627
Leishmania major DNA polymerase eta, putative 0.0033 0.0258 0.0632
Echinococcus granulosus dna polymerase kappa 0.0058 0.0638 0.0638
Trichomonas vaginalis CMGC family protein kinase 0.01 0.125 0.2337
Loa Loa (eye worm) pyridoxal-phosphate dependent enzyme family protein 0.0039 0.0348 0.0348
Mycobacterium ulcerans DNA polymerase IV 0.0058 0.0638 0.0817
Loa Loa (eye worm) hypothetical protein 0.0144 0.1909 0.1909
Echinococcus multilocularis mitogen activated protein kinase 3 0.01 0.125 0.125
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0229 0.0229
Mycobacterium tuberculosis Probable dehydrogenase 0.0083 0.1008 0.2346
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0229 0.0373
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Echinococcus granulosus mitogen activated protein kinase 3 0.01 0.125 0.125
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0638 0.156
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0018 0.0035 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0638 0.156
Leishmania major DNA polymerase kappa, putative 0.0039 0.0353 0.0862
Onchocerca volvulus 0.0031 0.0229 0.0373
Leishmania major tyrosine specific protein phosphatase, putative 0.0018 0.0035 0.0086
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0258 0.0258
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0704 0.0704
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0155 0.2068 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0353 0.0862
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0457 0.0812
Trypanosoma cruzi cysteine synthase, putative 0.0155 0.2068 0.5057
Trichomonas vaginalis cysteine synthase, putative 0.0155 0.2068 0.3911
Mycobacterium ulcerans hypothetical protein 0.0154 0.2048 0.3635
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0638 0.156
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0035 0.0035
Onchocerca volvulus Huntingtin homolog 0.0121 0.157 0.2953
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0369 0.5233 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0369 0.5233 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1817 0.4444
Schistosoma mansoni serine/threonine protein kinase 0.01 0.125 0.125
Trichomonas vaginalis cysteine synthase, putative 0.0155 0.2068 0.3911
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0719 0.0719
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0229 0.0373
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.0229
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.1146 0.276
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Trypanosoma cruzi serine sulfhydrylase 0.0155 0.2068 0.5057
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0457 0.0457
Trypanosoma cruzi threonine synthase, putative 0.0039 0.0348 0.0852
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0305 0.0747
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0638 0.156
Plasmodium falciparum thioredoxin reductase 0.0037 0.0316 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0031 0.0229 0.056
Trypanosoma cruzi cysteine synthase, putative 0.0155 0.2068 0.5057
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Brugia malayi Pre-SET motif family protein 0.003 0.0213 0.0213
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0035 0.0035
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0692 1 1
Echinococcus multilocularis 0.0018 0.0035 0.0035
Leishmania major cysteine synthase 0.0155 0.2068 0.5057
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0638 0.156
Loa Loa (eye worm) hypothetical protein 0.0026 0.0154 0.0154
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0229 0.0229
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0704 0.0704
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0229 0.0373
Entamoeba histolytica threonine dehydratase catabolic, putative 0.0039 0.0348 0.0603
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0229 0.0373
Echinococcus multilocularis mitogen activated protein kinase 0.01 0.125 0.125
Toxoplasma gondii thioredoxin reductase 0.0037 0.0316 0.1529
Mycobacterium tuberculosis Tryptophan synthase, beta subunit TrpB 0.0039 0.0348 0.0359
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0016 0.002 0.0096
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.0035 0.0035
Echinococcus granulosus geminin 0.0332 0.4678 0.4678
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0323 0.0323
Trypanosoma cruzi serine-threonine dehydratase, putative 0.0039 0.0348 0.0852
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0035 0.0035
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0616 0.0616
Echinococcus multilocularis hypothetical protein 0.0018 0.0035 0.0035
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0083 0.1008 0.2346
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0457 0.0457
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.4089 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0229 0.0373
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0035 0.0035
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0369 0.5233 0.5233
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0457 0.0457
Brugia malayi Pyridoxal-phosphate dependent enzyme family protein 0.0039 0.0348 0.0348
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0035 0.0035
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0018 0.0035 0.0035
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0382 0.0935
Trypanosoma brucei trypanothione reductase 0.0037 0.0316 0.0773
Loa Loa (eye worm) hypothetical protein 0.0052 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0035 0.0035
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0035 0.0035
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0323 0.0323
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0316 0.0773
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0229 0.0373
Echinococcus granulosus aldo keto reductase 0.0031 0.0229 0.0229
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0229 0.0229
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0229 0.0229
Onchocerca volvulus 0.0235 0.3245 0.6176
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0161 0.0161
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0031 0.0229 0.0666
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Entamoeba histolytica cysteine synthase A, putative 0.0155 0.2068 0.3911
Loa Loa (eye worm) hypothetical protein 0.0046 0.0457 0.0457
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0035 0.0035
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0035 0.0035
Mycobacterium tuberculosis Probable reductase 0.0083 0.1008 0.2346
Loa Loa (eye worm) hypothetical protein 0.0121 0.157 0.157
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.125 0.3057
Onchocerca volvulus Huntingtin homolog 0.0121 0.157 0.2953
Trichomonas vaginalis threonine synthase, putative 0.0155 0.2068 0.3911
Onchocerca volvulus 0.003 0.0213 0.0342
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0035 0.0035
Giardia lamblia Aldose reductase 0.0031 0.0229 0.0373
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0229 0.0373
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0229 0.0229
Trichomonas vaginalis cysteine synthase, putative 0.0155 0.2068 0.3911
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0692 1 1
Toxoplasma gondii pyridoxal-phosphate dependent superfamily protein 0.0155 0.2068 1
Schistosoma mansoni lamin 0.0026 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0316 0.0316
Mycobacterium leprae Probable threonine dehydratase IlvA 0.0039 0.0348 0.1272
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0638 0.156
Giardia lamblia Aldose reductase 0.0031 0.0229 0.0373
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0457 0.0457
Onchocerca volvulus 0.0369 0.5233 1
Entamoeba histolytica threonine dehydratase, putative 0.0039 0.0348 0.0603
Brugia malayi intermediate filament protein 0.0026 0.0161 0.0161
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0018 0.0035 0.0035
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0258 0.0429
Echinococcus granulosus intermediate filament protein 0.0026 0.0161 0.0161
Trichomonas vaginalis threonine dehydratase/deaminase, putative 0.0039 0.0348 0.0603
Trypanosoma cruzi cystathionine beta-synthase, putative 0.0155 0.2068 0.5057
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0369 0.5233 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0035 0.0035
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Trichomonas vaginalis threonine dehydratase/deaminase, putative 0.0039 0.0348 0.0603
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.01 0.125 0.3057
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0369 0.5233 1
Echinococcus multilocularis aldo keto reductase 0.0031 0.0229 0.0229
Entamoeba histolytica aldose reductase, putative 0.0031 0.0229 0.0373
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0229 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0305 0.0747
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Brugia malayi MAP kinase sur-1 0.01 0.125 0.125
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.1146 0.276
Onchocerca volvulus 0.0039 0.0348 0.0603
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0665 0.1313
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.2048 0.5476
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Trypanosoma cruzi cystathionine beta-synthase, putative 0.0155 0.2068 0.5057
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0719 0.1758
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0018 0.0035 0.0035
Loa Loa (eye worm) protein tyrosine phosphatase 0.0018 0.0035 0.0035
Trichomonas vaginalis threonine dehydratase/deaminase, putative 0.0039 0.0348 0.0603
Mycobacterium tuberculosis Probable threonine dehydratase IlvA 0.0039 0.0348 0.0359
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.4089 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0213 0.0213
Toxoplasma gondii CBS family protein 0.0155 0.2068 1
Brugia malayi hypothetical protein 0.0018 0.0035 0.0035
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0229 0.0373
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Brugia malayi TAR-binding protein 0.0063 0.0704 0.0704
Mycobacterium ulcerans tryptophan synthase subunit beta 0.0039 0.0348 0.0238
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0704 0.0704
Brugia malayi Pyridoxal-phosphate dependent enzyme family protein 0.0155 0.2068 0.2068
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0704 0.0704
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0018 0.0035 0.0035
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0457 0.0457
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0229 0.0373
Trichomonas vaginalis cysteine synthase, putative 0.0155 0.2068 0.3911
Mycobacterium ulcerans threonine synthase 0.0039 0.0348 0.0238
Brugia malayi Pyridoxal-phosphate dependent enzyme family protein 0.0039 0.0348 0.0348
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0018 0.0035 0.0035
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0229 0.0373
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0382 0.0935
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0229 0.0229
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0258 0.0258
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0035 0.0035
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0145 0.459
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0203 0.0496
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Echinococcus granulosus aldehyde reductase 0.0022 0.0098 0.0098
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0369 0.5233 1
Echinococcus multilocularis aldo keto reductase 0.0031 0.0229 0.0229
Echinococcus multilocularis aldo keto reductase 0.0031 0.0229 0.0229
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0719 0.1758
Brugia malayi hypothetical protein 0.0018 0.0035 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0704 0.0704
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0322 0.0322
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0018 0.0035 0.0035
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Trypanosoma brucei protein kinase, putative 0.01 0.125 0.3057
Trypanosoma brucei DNA polymerase IV, putative 0.0052 0.0544 0.133
Trypanosoma brucei protein tyrosine phosphatase 1 0.0018 0.0035 0.0086
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0515 0.126
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0719 0.0719
Onchocerca volvulus Serine racemase homolog 0.0039 0.0348 0.0603
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0369 0.5233 1
Echinococcus multilocularis aldo keto reductase 0.0031 0.0229 0.0229
Schistosoma mansoni cysteine synthase 0.0155 0.2068 0.2068
Echinococcus granulosus dna polymerase eta 0.0033 0.0258 0.0258
Brugia malayi hypothetical protein 0.0018 0.0035 0.0035
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0665 0.0665
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0638 0.156
Toxoplasma gondii O-acetylserine (thiol) lyase 2, putative 0.0039 0.0348 0.1685
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0229 0.0229
Schistosoma mansoni pol-related 0.0031 0.0229 0.0229
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0229 0.0373
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0616 0.0616
Loa Loa (eye worm) oxidoreductase 0.0031 0.0229 0.0229
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0035 0.0035
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0018 0.0035 0.0035
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.01 0.125 0.3057
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0203 0.0496
Mycobacterium ulcerans cysteine synthase 0.0039 0.0348 0.0238
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0035 0.0035
Loa Loa (eye worm) oxidoreductase 0.0031 0.0229 0.0229
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0638 0.156
Trichomonas vaginalis set domain proteins, putative 0.0235 0.3245 0.6176
Loa Loa (eye worm) hypothetical protein 0.0026 0.0161 0.0161
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0035 0.0035
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0665 0.0872
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0665 0.0665
Brugia malayi hypothetical protein 0.0016 0.0014 0.0014
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0258 0.0632
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0229 0.0229
Toxoplasma gondii hypothetical protein 0.0047 0.0472 0.2281
Onchocerca volvulus 0.0026 0.0161 0.0242
Mycobacterium leprae Probable tryptophan synthase, beta subunit TrpB 0.0039 0.0348 0.1272
Echinococcus granulosus lamin 0.0026 0.0161 0.0161
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0114 0.1458 0.3566
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0213 0.0213
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0229 0.0373
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0229 0.0229
Onchocerca volvulus 0.0031 0.0229 0.0373
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0229 0.0229
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0704 0.0704
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0018 0.0035 0.0035
Brugia malayi glutathione reductase 0.0037 0.0316 0.0316
Mycobacterium ulcerans DNA polymerase IV 0.0058 0.0638 0.0817
Schistosoma mansoni hypothetical protein 0.028 0.3917 0.3917
Schistosoma mansoni myelin transcription factor 1 myt1 0.0052 0.0552 0.0552
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.1458 0.3566
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0083 0.1008 0.2346
Schistosoma mansoni intermediate filament proteins 0.0026 0.0161 0.0161
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0229 0.0229
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0145 0.459
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0083 0.1008 0.4621
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0035 0.0035
Trypanosoma cruzi serine sulfhydrylase 0.0155 0.2068 0.5057
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.01 0.125 0.125
Echinococcus granulosus l serine dehydratase:l threonine deaminase 0.0039 0.0348 0.0348
Trichomonas vaginalis CMGC family protein kinase 0.01 0.125 0.2337
Leishmania major cystathionine beta-synthase 0.0155 0.2068 0.5057
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Loa Loa (eye worm) glutathione reductase 0.0037 0.0316 0.0316
Mycobacterium ulcerans cysteine synthase a CysK1 0.0155 0.2068 0.3675
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0182 0.246 0.246
Plasmodium vivax SET domain protein, putative 0.003 0.0213 0.6741
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.1146 0.276
Mycobacterium tuberculosis Probable lyase 0.0039 0.0348 0.0359
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.0035 0.0086
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0229 0.0373
Trypanosoma cruzi serine sulfhydrylase 0.0155 0.2068 0.5057
Onchocerca volvulus 0.0031 0.0229 0.0373
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0213 0.0213
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0035 0.0035
Brugia malayi Muscleblind-like protein 0.0144 0.1909 0.1909
Echinococcus multilocularis dna polymerase eta 0.0033 0.0258 0.0258
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0258 0.0258
Brugia malayi polk-prov protein 0.0036 0.0305 0.0305
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0353 0.0372
Echinococcus granulosus hypothetical protein 0.0031 0.0229 0.0229
Brugia malayi Protein-tyrosine phosphatase 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0033 0.0258 0.0258
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.0025 0.0145 0.0145
Toxoplasma gondii aldose reductase, putative 0.0031 0.0229 0.1108
Mycobacterium leprae PROBABLE THREONINE SYNTHASE THRC 0.0039 0.0348 0.1272
Trypanosoma brucei unspecified product 0.0052 0.0544 0.133
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0616 0.0616
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0018 0.0035 0.0035
Trypanosoma cruzi aldo/keto reductase, putative 0.0031 0.0229 0.056
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0018 0.0035 0.0035
Leishmania major threonine synthase, putative 0.0039 0.0348 0.0852
Brugia malayi hypothetical protein 0.0025 0.0145 0.0145
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0035 0.0035
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0213 0.1031
Chlamydia trachomatis tryptophan synthase subunit beta 0.0039 0.0348 0.5
Echinococcus multilocularis musashi 0.0026 0.0161 0.0161
Echinococcus granulosus lamin dm0 0.0026 0.0161 0.0161
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0035 0.0035
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0035 0.0035
Giardia lamblia DINP protein human, muc B family 0.0039 0.0353 0.0611
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0018 0.0035 0.0035
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0018 0.0035 0.0035
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0035 0.0035
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0638 0.156
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0457 0.0457
Trypanosoma cruzi serine-threonine dehydratase, putative 0.0039 0.0348 0.0852
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0229 0.0229
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0353 0.0862
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0114 0.1458 0.2738
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0332 0.4678 0.4678
Onchocerca volvulus 0.0031 0.0229 0.0373
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0638 0.156
Echinococcus multilocularis aldehyde reductase 0.0022 0.0098 0.0098
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0616 0.0616
Echinococcus granulosus tar DNA binding protein 0.0063 0.0704 0.0704
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0035 0.0035
Mycobacterium tuberculosis Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B) 0.0155 0.2068 0.5537
Leishmania major serine-threonine dehydratase, putative 0.0039 0.0348 0.0852
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.003 0.0213 0.0213
Loa Loa (eye worm) MBCTL1 0.0052 0.0552 0.0552
Brugia malayi Protein-tyrosine phosphatase 0.0018 0.0035 0.0035
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0035 0.0035
Leishmania major hypothetical protein, conserved 0.0114 0.1458 0.3566
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0058 0.0638 0.116
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0035 0.0035
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0369 0.5233 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0031 0.0229 0.056
Entamoeba histolytica aldose reductase, putative 0.0031 0.0229 0.0373
Echinococcus multilocularis lamin dm0 0.0026 0.0161 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0638 0.156
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0616 0.0616
Schistosoma mansoni aldo-keto reductase 0.0031 0.0229 0.0229
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0213 0.0213
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0457 0.0457
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0035 0.0035
Trypanosoma cruzi cystathionine beta-synthase 0.0155 0.2068 0.5057
Brugia malayi mbt repeat family protein 0.0046 0.0457 0.0457
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0665 0.0665
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0616 0.0616
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0213 0.0213
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.1146 0.5319
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0083 0.1008 0.2346
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Trypanosoma cruzi serine-threonine dehydratase, putative 0.0039 0.0348 0.0852
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0719 0.0719
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0035 0.0035
Trypanosoma cruzi threonine synthase, putative 0.0039 0.0348 0.0852
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0052 0.0552 0.0552
Echinococcus granulosus mitogen activated protein kinase 0.01 0.125 0.125
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0035 0.0035
Trichomonas vaginalis threonine dehydratase/deaminase, putative 0.0039 0.0348 0.0603
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0719 0.1758
Brugia malayi jmjC domain containing protein 0.0057 0.0616 0.0616
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0229 0.0373
Plasmodium vivax glutathione reductase, putative 0.0037 0.0316 1
Giardia lamblia Kinase, CMGC MAPK 0.01 0.125 0.2337
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0035 0.0035
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0035 0.0035
Loa Loa (eye worm) oxidoreductase 0.0031 0.0229 0.0229
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0719 0.0719
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0258 0.0258
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Trypanosoma cruzi serine sulfhydrylase 0.0155 0.2068 0.5057
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0229 0.0229
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1817 0.4444
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0035 0.0035
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0035 0.0035
Mycobacterium ulcerans threonine dehydratase 0.0039 0.0348 0.0238
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0203 0.0496
Loa Loa (eye worm) hypothetical protein 0.0121 0.157 0.157
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0229 0.0229
Brugia malayi mbt repeat family protein 0.0046 0.0457 0.0457
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0229 0.0373
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0114 0.1458 0.2738
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0145 0.459
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Loa Loa (eye worm) cbs-prov protein 0.0155 0.2068 0.2068
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0322 0.0322
Brugia malayi Pre-SET motif family protein 0.0206 0.2824 0.2824
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0052 0.0552 0.0552
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0692 1 1
Schistosoma mansoni threonine dehydratase/deaminase 0.0039 0.0348 0.0348
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0258 0.0258
Echinococcus multilocularis l serine dehydratase:l threonine deaminase 0.0039 0.0348 0.0348
Trypanosoma cruzi cystathionine beta-synthase, putative 0.0155 0.2068 0.5057
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0182 0.246 0.246
Plasmodium falciparum glutathione reductase 0.0037 0.0316 1
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0369 0.5233 0.5233
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0229 0.0229
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0161 0.0161
Entamoeba histolytica cysteine synthase A, putative 0.0155 0.2068 0.3911
Schistosoma mansoni pcd6 interacting protein-related 0.0018 0.0035 0.0035
Brugia malayi hypothetical protein 0.0018 0.0035 0.0035
Loa Loa (eye worm) RNA binding protein 0.0063 0.0704 0.0704
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0035 0.0035
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0229 0.0229
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0197 0.0197
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0018 0.0035 0.0086
Echinococcus granulosus histone acetyltransferase MYST2 0.0052 0.0552 0.0552
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.1458 0.3566
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0229 0.0229
Echinococcus multilocularis histone acetyltransferase MYST2 0.0052 0.0552 0.0552
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0616 0.0616
Mycobacterium tuberculosis Cysteine synthase a CysK1 (O-acetylserine sulfhydrylase A) (O-acetylserine (thiol)-lyase A) (CSASE A) 0.0155 0.2068 0.5537
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0036 0.0305 0.0305
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0316 0.0262
Echinococcus multilocularis dna polymerase kappa 0.0058 0.0638 0.0638
Brugia malayi hypothetical protein 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Brugia malayi hypothetical protein 0.0121 0.157 0.157
Entamoeba histolytica threonine dehydratase, putative 0.0039 0.0348 0.0603
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0161 0.0161
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.9631 0.9631
Loa Loa (eye worm) oxidoreductase 0.0031 0.0229 0.0229
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0229 0.0229
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0035 0.0035
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.01 0.125 0.6044
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0018 0.0035 0.0035
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0258 0.0258
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0719 0.1758
Schistosoma mansoni aldo-keto reductase 0.0031 0.0229 0.0229
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0616 0.0616
Mycobacterium ulcerans cystathionine beta-synthase 0.0155 0.2068 0.3675
Trypanosoma cruzi cystathionine beta-synthase 0.0155 0.2068 0.5057
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.01 0.125 0.3057
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0665 0.0872
Brugia malayi cbs-prov protein 0.0155 0.2068 0.2068
Leishmania major hypothetical protein, conserved 0.0025 0.0145 0.0355
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0018 0.0035 0.0035
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0719 0.1315

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.13 uM Antitubercular activity against Mycobacterium tuberculosis H37Rv by MABA method ChEMBL. 21069962
MIC (functional) = 1.2 uM Antitubercular activity against Mycobacterium tuberculosis H37Rv by LORA method ChEMBL. 21069962

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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