Detailed information for compound 1464777

Basic information

Technical information
  • TDR Targets ID: 1464777
  • Name: N-[(2-chloro-6-fluorophenyl)methyl]-1,1-di(ph enyl)methanamine
  • MW: 325.807 | Formula: C20H17ClFN
  • H donors: 1 H acceptors: 0 LogP: 5.21 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1CNC(c1ccccc1)c1ccccc1)Cl
  • InChi: 1S/C20H17ClFN/c21-18-12-7-13-19(22)17(18)14-23-20(15-8-3-1-4-9-15)16-10-5-2-6-11-16/h1-13,20,23H,14H2
  • InChiKey: JATLPCOUVWPKNJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(2-chloro-6-fluoro-phenyl)methyl]-1,1-di(phenyl)methanamine
  • (2-chloro-6-fluoro-benzyl)-[di(phenyl)methyl]amine
  • AN-465/41988230

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0184 0.0127 0.2895
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0005 0.0994
Trypanosoma brucei target of rapamycin kinase 3, putative 0.091 0.075 0.9884
Trichomonas vaginalis PIKK family atypical protein kinase 0.091 0.075 0.9884
Leishmania major hypothetical protein, unknown function 0.0184 0.0127 0.0343
Loa Loa (eye worm) hypothetical protein 0.0535 0.0428 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0184 0.0127 0.1653
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0005 0.0134
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0943 0.0778 0.2236
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0184 0.0127 0.0124
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0005 0.0994
Loa Loa (eye worm) beta-lactamase 0.0041 0.0005 0.0063
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0814 0.0668 0.0665
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.0176 0.2226
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0513 0.0409 0.538
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0241 0.0176 0.05
Loa Loa (eye worm) hypothetical protein 0.0535 0.0428 0.5645
Leishmania major phosphatidylinositol kinase related protein, putative 0.02 0.0141 0.0381
Schistosoma mansoni hypothetical protein 0.0873 0.0718 0.9231
Brugia malayi Inositol-1 0.0045 0.0008 0.0058
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0021 0.0277
Echinococcus granulosus geminin 0.0873 0.0718 0.0716
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0943 0.0778 1
Schistosoma mansoni hypothetical protein 0.0184 0.0127 0.1603
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0184 0.0127 0.7143
Loa Loa (eye worm) phosphatidylinositol 3 0.0184 0.0127 0.1679
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0507 0.0405 0.0402
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0093 0.1227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0519 0.0415 0.5456
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0038 0.0035
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0184 0.0127 0.0358
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0005 0.0002
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0241 0.0176 0.2302
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.092 0.0759 1
Loa Loa (eye worm) hypothetical protein 0.02 0.0141 0.1858
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0009 0.0006
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0313 0.0238 0.3111
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0187 0.2444
Loa Loa (eye worm) hypothetical protein 0.0041 0.0005 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.091 0.075 0.9884
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.024 0.0176 0.0173
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0038 0.0447
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0184 0.0127 0.1603
Trichomonas vaginalis PIKK family atypical protein kinase 0.091 0.075 0.9884
Loa Loa (eye worm) hypothetical protein 0.0041 0.0005 0.0063
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.002 0.0048
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0184 0.0127 0.0124
Schistosoma mansoni lozenge 0.0067 0.0027 0.0307
Leishmania major phosphatidylinositol 3-kinase, putative 0.0241 0.0176 0.0478
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0112 0.1454
Brugia malayi MH2 domain containing protein 0.0144 0.0093 0.116
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0008 0.0013
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0241 0.0176 0.2302
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0005 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0528 0.0422 0.5552
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0004 0.0026
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0814 0.0668 0.0665
Entamoeba histolytica protein kinase rad3, putative 0.0507 0.0405 0.5287
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0184 0.0127 0.1603
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0004 0.0041
Toxoplasma gondii target of rapamycin (TOR), putative 0.0907 0.0748 1
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0008 0.0005
Brugia malayi Fli-1 protein 0.0218 0.0156 0.1973
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.092 0.0759 0.9748
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0184 0.0127 0.1645
Loa Loa (eye worm) fli-1 protein 0.0218 0.0156 0.2056
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0008 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0907 0.0748 0.9854
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.024 0.0176 0.2226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.0739 0.9739
Schistosoma mansoni hypothetical protein 0.0041 0.0005 0.002
Loa Loa (eye worm) hypothetical protein 0.0563 0.0453 0.5968
Mycobacterium tuberculosis Conserved protein 0.0041 0.0005 0.0086
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0313 0.0238 0.3062
Loa Loa (eye worm) hypothetical protein 0.0041 0.0005 0.0063
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0005 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0524 0.0419 0.5505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0541 0.0433 0.5698
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.092 0.0759 1
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0112 0.1454
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0422 0.0331 0.4236
Entamoeba histolytica hypothetical protein 0.0184 0.0127 0.1594
Loa Loa (eye worm) hypothetical protein 0.0422 0.0331 0.4369
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0622 0.0503 0.645
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0351 0.027 0.3497
Trichomonas vaginalis PIKK family atypical protein kinase 0.0907 0.0748 0.9854
Loa Loa (eye worm) phosphatidylinositol kinase 0.0184 0.0127 0.1679
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.002 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0586 0.0472 0.6217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.0739 0.9738
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0031 0.0028
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0379 0.0295 0.0292
Echinococcus multilocularis neuropeptide s receptor 0.0973 0.0804 0.0801
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0241 0.0176 0.2236
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0313 0.0238 0.3111
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0005 0.002
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0622 0.0503 0.6621
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0241 0.0176 0.2302
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0241 0.0176 0.2327
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0441 0.0348 0.3495
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0128 0.008 0.0221
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0112 0.1454
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.092 0.0759 0.2179
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0313 0.0238 0.3104
Trichomonas vaginalis PIKK family atypical protein kinase 0.09 0.0741 0.9768
Brugia malayi Ets-domain containing protein 0.0072 0.0031 0.0358
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0005 0.0032
Loa Loa (eye worm) phosphatidylinositol 3 0.0128 0.008 0.105
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0005 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.408 0.3469 1
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0031 0.0028
Echinococcus multilocularis neuropeptide receptor A26 0.0973 0.0804 0.0801
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0112 0.1454
Brugia malayi FAT domain containing protein 0.0379 0.0295 0.3763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.0739 0.9739
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0031 0.0407
Mycobacterium tuberculosis Conserved protein 0.0041 0.0005 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0887 0.073 0.9622
Trypanosoma cruzi target of rapamycin kinase 3 0.091 0.075 0.2154
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0008 0.0061
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0241 0.0176 0.0173
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0184 0.0127 0.7143
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0187 0.2444
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.012 0.1556
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0184 0.0127 0.1669
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0187 0.2444
Loa Loa (eye worm) runx1 0.0067 0.0027 0.0355
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0899 0.074 0.9758
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.0739 0.9738
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0422 0.0331 0.0328
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0184 0.0127 0.7143
Loa Loa (eye worm) cytochrome P450 family protein 0.0124 0.0076 0.1001
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0264 0.0196 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.092 0.0759 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0241 0.0176 0.2325
Trichomonas vaginalis PIKK family atypical protein kinase 0.0887 0.073 0.9622
Trichomonas vaginalis conserved hypothetical protein 0.0379 0.0295 0.3867
Trichomonas vaginalis PIKK family atypical protein kinase 0.092 0.0759 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0005 0.0063
Schistosoma mansoni hypothetical protein 0.0379 0.0295 0.3763
Loa Loa (eye worm) hypothetical protein 0.0041 0.0005 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.0739 0.9738
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.091 0.075 0.206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0184 0.0127 0.1653
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.1694 1 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0008 0.0013
Loa Loa (eye worm) phosphatidylinositol 3 0.0184 0.0127 0.1679
Plasmodium vivax hypothetical protein 0.0184 0.0127 0.7143
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0038 0.0035
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0008 0.006
Loa Loa (eye worm) hypothetical protein 0.0507 0.0405 0.5334
Giardia lamblia GTOR 0.092 0.0759 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0005 0.0032
Leishmania major hypothetical protein, conserved 0.0041 0.0005 0.0005
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0038 0.0498
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0256 0.0189 0.097
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0008 0.2702
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0192 0.0134 0.1693
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0184 0.0127 0.1669
Echinococcus multilocularis Protein lozenge 0.0067 0.0027 0.0024
Mycobacterium leprae conserved hypothetical protein 0.0184 0.0127 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0507 0.0405 0.5181
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0313 0.0238 0.3025
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0184 0.0127 0.0358
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0038 0.0401
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.024 0.0176 0.0173
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.092 0.0759 0.2084
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0551 0.0442 0.5782
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.0176 0.2226
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0563 0.0453 0.6039
Entamoeba histolytica hypothetical protein 0.0551 0.0442 0.5782
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0038 0.0447
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0005 0.0061
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0038 0.0458
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.02 0.0141 0.0399
Loa Loa (eye worm) phosphatidylinositol 3 0.092 0.0759 1
Entamoeba histolytica hypothetical protein 0.0184 0.0127 0.1594
Mycobacterium ulcerans beta-lactamase 0.0041 0.0005 0.0994
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0184 0.0127 0.1603
Trichomonas vaginalis PIKK family atypical protein kinase 0.092 0.0759 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0943 0.0778 0.0775
Loa Loa (eye worm) CYP4Cod1 0.0059 0.002 0.0262
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0438 0.0345 0.4493
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0005 0.0005
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0241 0.0176 0.0173
Loa Loa (eye worm) hypothetical protein 0.0379 0.0295 0.3886
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0241 0.0176 0.0478
Brugia malayi Cytochrome P450 family protein 0.0124 0.0076 0.0939
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0008 0.0012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0005 0.0021
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0943 0.0778 0.0775
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0005 0.0032
Trichomonas vaginalis esterase, putative 0.0041 0.0005 0.0032
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0184 0.0127 0.0124
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.092 0.0759 1
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0184 0.0127 0.1594
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0112 0.1454
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0005 0.0021
Loa Loa (eye worm) hypothetical protein 0.0041 0.0005 0.0063
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0622 0.0503 0.6621
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.024 0.0176 0.0173
Brugia malayi beta-lactamase 0.0041 0.0005 0.0021
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0524 0.0419 0.5362
Trichomonas vaginalis conserved hypothetical protein 0.0323 0.0247 0.3231
Loa Loa (eye worm) phosphatidylinositol 3 0.0899 0.074 0.9759
Onchocerca volvulus 0.0535 0.0428 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0008 0.007
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0313 0.0238 0.0676
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0241 0.0176 0.2236
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.092 0.0759 0.2179
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0005 0.0086
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0005 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.09 0.0741 0.9768
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0241 0.0176 0.2327
Trichomonas vaginalis PIKK family atypical protein kinase 0.091 0.075 0.9884
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0241 0.0176 0.05
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0005 0.0002
Leishmania major phosphatidylinositol 4-kinase, putative 0.0184 0.0127 0.0343
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0008 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0005 0.0032
Loa Loa (eye worm) inositol-1 0.0045 0.0008 0.0101
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0313 0.0238 0.3062
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0943 0.0778 1
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0009 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.012 0.1556
Leishmania major phosphatidylinositol 3-kinase, putative 0.0887 0.073 0.2005
Entamoeba histolytica hypothetical protein 0.0524 0.0419 0.5473
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0005 0.0086
Schistosoma mansoni gabp alpha 0.0072 0.0031 0.0358
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.0187 0.2375
Leishmania major hypothetical protein, conserved 0.4264 0.3627 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0021 0.0231
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.034 0.0261 0.0743
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0038 0.0096
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.0187 0.2468
Trichomonas vaginalis PIKK family atypical protein kinase 0.0887 0.073 0.9622
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0899 0.074 0.2034
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0241 0.0176 0.0173
Brugia malayi beta-lactamase family protein 0.0041 0.0005 0.0021
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0005 0.002
Loa Loa (eye worm) hypothetical protein 0.006 0.0021 0.0277
Echinococcus granulosus serine protein kinase ATM 0.0524 0.0419 0.0416
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0241 0.0176 0.2293
Trypanosoma brucei cytochrome P450, putative 0.0059 0.002 0.0221
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0943 0.0778 0.2236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0194 0.0136 0.1769
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0622 0.0503 0.6621
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0184 0.0127 0.1653
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0008 0.007
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0887 0.073 0.9622
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.024 0.0176 0.0173
Mycobacterium tuberculosis Conserved protein 0.0041 0.0005 0.0086
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0005 0.0086
Entamoeba histolytica hypothetical protein 0.0184 0.0127 0.1594
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0187 0.2444
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0021 0.0231
Mycobacterium ulcerans hypothetical protein 0.0041 0.0005 0.0994
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0519 0.0415 0.5424
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0184 0.0127 0.0358
Loa Loa (eye worm) phosphatidylinositol 3 0.0184 0.0127 0.1679
Echinococcus multilocularis 0.0184 0.0127 0.0124
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.002 0.0048
Loa Loa (eye worm) hypothetical protein 0.0184 0.0127 0.1679
Brugia malayi hypothetical protein 0.0535 0.0428 0.5485
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0187 0.2444
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.092 0.0759 0.9748
Loa Loa (eye worm) hypothetical protein 0.0041 0.0005 0.0063
Brugia malayi beta-lactamase family protein 0.0041 0.0005 0.0021
Echinococcus multilocularis serine protein kinase ATM 0.0524 0.0419 0.0416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0907 0.0748 0.9854
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.092 0.0759 0.0756
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0008 0.0005
Loa Loa (eye worm) phosphatidylinositol 3 0.0743 0.0607 0.7999
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0005 0.0086
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0241 0.0176 0.2236
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0507 0.0405 0.1158
Echinococcus multilocularis Zinc finger, PHD finger 0.0241 0.0176 0.0173
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0241 0.0176 0.2247
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0187 0.2444
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0205 0.0145 0.1877
Mycobacterium ulcerans lipase LipD 0.0041 0.0005 0.0994
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0184 0.0127 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.092 0.0759 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0313 0.0238 0.3025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.0739 0.9739
Echinococcus granulosus neuropeptide receptor A26 0.0973 0.0804 0.0801
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0313 0.0238 0.3111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0323 0.0247 0.3231
Schistosoma mansoni inositol monophosphatase 0.0045 0.0008 0.0058
Loa Loa (eye worm) cytochrome P450 0.0039 0.0003 0.0041
Mycobacterium leprae Probable lipase LipE 0.0041 0.0005 0.0134
Leishmania major cytochrome p450-like protein 0.0059 0.002 0.0046
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0622 0.0503 0.1442
Brugia malayi Cytochrome P450 family protein 0.0059 0.002 0.0216
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0005 0.0086
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0507 0.0405 0.0402
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.002 0.0262
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0184 0.0127 0.0358
Toxoplasma gondii FATC domain-containing protein 0.0524 0.0419 0.5582
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0814 0.0668 0.8579
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0524 0.0419 0.1199
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.0112 0.2539
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0005 0.0022
Loa Loa (eye worm) hypothetical protein 0.0061 0.0022 0.0289
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0184 0.0127 0.1669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0907 0.0748 0.9854
Echinococcus multilocularis geminin 0.0873 0.0718 0.0716
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0059 0.002 1
Schistosoma mansoni inositol monophosphatase 0.0045 0.0008 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0528 0.0422 0.5552
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.024 0.0176 0.2315
Brugia malayi Cytochrome P450 family protein 0.0059 0.002 0.0216
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0574 0.0461 0.6068
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0005 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.0739 0.9739
Schistosoma mansoni ets-related 0.0218 0.0156 0.1973
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0622 0.0503 0.6597
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0184 0.0127 0.1645
Echinococcus granulosus neuropeptide s receptor 0.0973 0.0804 0.0801
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0622 0.0503 0.1442
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0093 0.1227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0887 0.073 0.9622
Trichomonas vaginalis PIKK family atypical protein kinase 0.0899 0.074 0.9758
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0184 0.0127 0.1603
Schistosoma mansoni hypothetical protein 0.0873 0.0718 0.9231
Toxoplasma gondii ABC1 family protein 0.0041 0.0005 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0005 0.0032
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0038 0.01
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0241 0.0176 0.2247
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0422 0.0331 0.0328
Loa Loa (eye worm) phosphatidylinositol 3 0.0184 0.0127 0.1679
Brugia malayi Ets-domain containing protein 0.0072 0.0031 0.0358
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0184 0.0127 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0112 0.1454
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0507 0.0405 0.5181
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0008 0.0061
Loa Loa (eye worm) hypothetical protein 0.0041 0.0005 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0528 0.0422 0.5552
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0241 0.0176 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.053 0.0424 0.5581
Trichomonas vaginalis PIKK family atypical protein kinase 0.091 0.075 0.9884
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0184 0.0127 0.1603
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0524 0.0419 0.55
Trichomonas vaginalis PIKK family atypical protein kinase 0.0507 0.0405 0.532
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0184 0.0127 0.1653
Trichomonas vaginalis PIKK family atypical protein kinase 0.0907 0.0748 0.9854
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0241 0.0176 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0907 0.0748 0.9854
Mycobacterium tuberculosis Conserved hypothetical protein 0.0184 0.0127 0.6454
Loa Loa (eye worm) hypothetical protein 0.034 0.0261 0.3436
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.092 0.0759 0.2084
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0184 0.0127 0.1603
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.092 0.0759 0.0756
Leishmania major phosphatidylinositol kinase, putative 0.0184 0.0127 0.0343
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0008 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0005 0.0005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0524 0.0419 0.5362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0907 0.0748 0.9854
Trichomonas vaginalis conserved hypothetical protein 0.0563 0.0453 0.5956
Plasmodium vivax hypothetical protein, conserved 0.0184 0.0127 0.7143
Onchocerca volvulus 0.0184 0.0127 0.2895
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0038 0.01
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0513 0.0409 0.538
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0112 0.1454
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0379 0.0295 0.0292
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.0176 0.2226

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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