Detailed information for compound 1465984

Basic information

Technical information
  • TDR Targets ID: 1465984
  • Name: (8R,9S,13S,14S,17S)-3-amino-13-methyl-6,7,8,9 ,11,12,14,15,16,17-decahydrocyclopenta[a]phen anthren-17-ol
  • MW: 271.397 | Formula: C18H25NO
  • H donors: 2 H acceptors: 1 LogP: 3.58 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C
  • InChi: 1S/C18H25NO/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,20H,2,4,6-9,19H2,1H3/t14-,15-,16+,17+,18+/m1/s1
  • InChiKey: ZPGJDCAXHNQWAN-ZBRFXRBCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 10427-24-4
  • NSC90608

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus carboxylesterase 5A 0.0986 1 1
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0078 0.0248 0.0021
Echinococcus granulosus growth factor receptor bound protein 2 0.0154 0.1062 0.0855
Schistosoma mansoni tensin 0.0078 0.0248 0.0021
Echinococcus granulosus hexokinase 0.008 0.0274 0.0047
Echinococcus granulosus tyrosine protein kinase Src42A 0.0078 0.0248 0.0021
Loa Loa (eye worm) p53BP2 0.0076 0.0227 0.0227
Echinococcus granulosus SHC transforming protein 3 0.0078 0.0248 0.0021
Echinococcus multilocularis carboxylesterase 5A 0.0986 1 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0078 0.0248 0.0248
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0536 0.517 0.5057
Trypanosoma cruzi hexokinase, putative 0.008 0.0274 0.0072
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0175 0.1297 0.1094
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0986 1 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0154 0.1062 0.0855
Loa Loa (eye worm) hypothetical protein 0.0076 0.0227 0.0227
Brugia malayi SH2 domain containing protein 0.0078 0.0248 0.0021
Echinococcus multilocularis neuroligin 0.0167 0.1202 0.0997
Echinococcus granulosus suppressor of cytokine signaling 6 0.0078 0.0248 0.0021
Loa Loa (eye worm) hypothetical protein 0.0078 0.0248 0.0248
Schistosoma mansoni serine/threonine protein kinase 0.0422 0.3939 0.3798
Mycobacterium ulcerans carboxylesterase, LipT 0.0167 0.1202 0.031
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0155 0.1075 0.1317
Echinococcus granulosus hexokinase 0.008 0.0274 0.0047
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0155 0.1075 0.5
Echinococcus multilocularis tyrosine protein kinase Abl 0.0175 0.1297 0.1094
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0078 0.0248 0.0213
Echinococcus granulosus acetylcholinesterase 0.0986 1 1
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 2, putative 0.0675 0.6663 1
Echinococcus multilocularis tyrosine kinase 0.01 0.0483 0.0261
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0175 0.1297 0.1094
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0155 0.1075 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0483 0.0483
Entamoeba histolytica SH2 domain containing protein 0.0078 0.0248 0.0245
Onchocerca volvulus 0.01 0.0483 0.2619
Schistosoma mansoni GTPase activating protein 0.0078 0.0248 0.0021
Brugia malayi Protein kinase domain containing protein 0.01 0.0483 0.0261
Loa Loa (eye worm) carboxylesterase 0.0986 1 1
Echinococcus granulosus SH2 motif 0.0078 0.0248 0.0021
Treponema pallidum octaprenyl-diphosphate synthase 0.0235 0.1935 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0078 0.0248 0.0248
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0155 0.1075 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0177 0.1308 0.1106
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0078 0.0248 0.0021
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0483 0.0483
Echinococcus multilocularis 0.0078 0.0248 0.0021
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0078 0.0248 0.0021
Echinococcus granulosus tensin 0.0078 0.0248 0.0021
Loa Loa (eye worm) hypothetical protein 0.0076 0.0227 0.0227
Schistosoma mansoni BC026374 protein (S09 family) 0.0167 0.1202 0.0997
Schistosoma mansoni tyrosine kinase 0.01 0.0483 0.0261
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0483 0.0483
Echinococcus granulosus tyrosine protein kinase Fps85D 0.01 0.0483 0.0261
Onchocerca volvulus 0.0077 0.0239 0.0119
Schistosoma mansoni adapter molecule crk 0.0154 0.1062 0.0855
Onchocerca volvulus 0.008 0.0274 0.0475
Schistosoma mansoni growth factor receptor-bound protein 0.0154 0.1062 0.0855
Plasmodium vivax V-type H(+)-translocating pyrophosphatase, putative 0.0675 0.6663 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0248 0.0248
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0078 0.0248 0.0021
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0076 0.0227 0.0227
Loa Loa (eye worm) SH2 domain-containing protein 0.0078 0.0248 0.0248
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0078 0.0248 0.0021
Echinococcus multilocularis tensin 0.0078 0.0248 0.0021
Schistosoma mansoni glutathione synthetase 0.0155 0.1075 0.0867
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0483 0.0483
Loa Loa (eye worm) hypothetical protein 0.0076 0.0227 0.0227
Schistosoma mansoni gliotactin 0.0167 0.1202 0.0997
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0175 0.1297 0.1094
Echinococcus multilocularis tensin 0.0078 0.0248 0.0021
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0536 0.517 0.5057
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0483 0.0483
Echinococcus multilocularis tyrosine protein kinase Blk 0.01 0.0483 0.0261
Schistosoma mansoni tyrosine kinase 0.01 0.0483 0.0261
Giardia lamblia Farnesyl diphosphate synthase 0.0536 0.517 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0462 0.024
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0536 0.517 0.768
Loa Loa (eye worm) carboxylesterase 0.0167 0.1202 0.1202
Schistosoma mansoni suppressor of cytokine signaling 0.0078 0.0248 0.0021
Loa Loa (eye worm) hypothetical protein 0.0986 1 1
Schistosoma mansoni tensin 0.0078 0.0248 0.0021
Onchocerca volvulus 0.0167 0.1202 1
Onchocerca volvulus 0.0078 0.0248 0.0213
Echinococcus multilocularis hexokinase 0.008 0.0274 0.0047
Loa Loa (eye worm) hypothetical protein 0.0076 0.0227 0.0227
Schistosoma mansoni neuroligin 3 (S09 family) 0.0167 0.1202 0.0997
Schistosoma mansoni hypothetical protein 0.0078 0.0248 0.0021
Onchocerca volvulus 0.0078 0.0248 0.0213
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0167 0.1202 0.031
Echinococcus granulosus N chimaerin 0.0078 0.0248 0.0021
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 1 0.0675 0.6663 1
Brugia malayi Variant SH3 domain containing protein 0.0078 0.0248 0.0021
Echinococcus multilocularis NCK adaptor protein 0.0154 0.1062 0.0855
Leishmania major farnesyl pyrophosphate synthase 0.0536 0.517 0.768
Loa Loa (eye worm) hypothetical protein 0.0986 1 1
Brugia malayi Carboxylesterase family protein 0.0167 0.1202 0.0997
Onchocerca volvulus 0.0167 0.1202 1
Trypanosoma cruzi vacuolar-type proton translocating pyrophosphatase 1 0.0675 0.6663 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0154 0.1062 0.0855
Onchocerca volvulus 0.0167 0.1202 1
Loa Loa (eye worm) hexokinase 0.008 0.0274 0.0274
Trypanosoma cruzi hexokinase, putative 0.008 0.0274 0.0072
Loa Loa (eye worm) hypothetical protein 0.0078 0.0248 0.0248
Echinococcus multilocularis tyrosine protein kinase ABL1 0.01 0.0483 0.0261
Echinococcus granulosus neuroligin 0.0167 0.1202 0.0997
Echinococcus granulosus SH2 domain containing adapter protein F 0.0078 0.0248 0.0021
Echinococcus granulosus tyrosine protein kinase Fyn 0.0175 0.1297 0.1094
Brugia malayi SH2 domain containing protein 0.0078 0.0248 0.0021
Schistosoma mansoni hypothetical protein 0.0078 0.0248 0.0021
Brugia malayi STAT protein, DNA binding domain containing protein 0.0078 0.0248 0.0021
Echinococcus multilocularis SH2 motif 0.0078 0.0248 0.0021
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0078 0.0248 0.0021
Brugia malayi SH2 domain containing protein 0.01 0.0483 0.0261
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0078 0.0248 0.0021
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0155 0.1075 0.0867
Schistosoma mansoni tyrosine kinase 0.0175 0.1297 0.1094
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0483 0.0483
Echinococcus multilocularis SH2 motif 0.0078 0.0248 0.0021
Brugia malayi Sex muscle abnormal protein 5 0.0154 0.1062 0.0855
Brugia malayi Protein kinase domain containing protein 0.01 0.0483 0.0261
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0167 0.1202 0.1972
Loa Loa (eye worm) hypothetical protein 0.0167 0.1202 0.1202
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0536 0.517 0.7663
Echinococcus multilocularis signal transduction protein lnk realted 0.0078 0.0248 0.0021
Schistosoma mansoni hexokinase 0.008 0.0274 0.0047
Echinococcus granulosus tyrosine protein kinase Src64B 0.0175 0.1297 0.1094
Schistosoma mansoni tyrosine kinase 0.0175 0.1297 0.1094
Onchocerca volvulus 0.01 0.0483 0.2619
Onchocerca volvulus 0.0078 0.0248 0.0213
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0078 0.0248 0.0021
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.01 0.0483 0.0261
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0175 0.1297 0.1094
Brugia malayi Variant SH3 domain containing protein 0.0078 0.0248 0.0021
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0155 0.1075 0.0867
Brugia malayi Carboxylesterase family protein 0.0986 1 1
Schistosoma mansoni nck2/grb4 0.0154 0.1062 0.0855
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0483 0.0483
Echinococcus granulosus tyrosine protein kinase Blk 0.01 0.0483 0.0261
Entamoeba histolytica hexokinase 2 0.008 0.0274 0.0546
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0536 0.517 0.768
Brugia malayi SH2 domain containing protein 0.0078 0.0248 0.0021
Brugia malayi SH2 domain containing protein 0.0078 0.0248 0.0021
Onchocerca volvulus 0.0078 0.0248 0.0213
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0175 0.1297 0.1094
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0175 0.1297 0.1094
Brugia malayi Tensin 0.0078 0.0248 0.0021
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0422 0.3939 0.3939
Loa Loa (eye worm) hypothetical protein 0.0078 0.0248 0.0248
Brugia malayi map kinase activated protein kinase protein 2 0.0422 0.3939 0.3798
Loa Loa (eye worm) hexokinase 0.008 0.0274 0.0274
Loa Loa (eye worm) polyprenyl synthetase 0.0536 0.517 0.517
Plasmodium falciparum V-type H(+)-translocating pyrophosphatase, putative 0.0675 0.6663 1
Echinococcus granulosus tyrosine protein kinase shark 0.01 0.0483 0.0261
Loa Loa (eye worm) TK protein kinase 0.01 0.0483 0.0483
Onchocerca volvulus 0.01 0.0483 0.2619
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0175 0.1297 0.1094
Loa Loa (eye worm) hypothetical protein 0.0078 0.0248 0.0248
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0167 0.1202 0.0997
Echinococcus granulosus c src tyrosine kinase 0.0175 0.1297 0.1094
Echinococcus granulosus tyrosine protein kinase Srms 0.01 0.0483 0.0261
Entamoeba histolytica protein kinase, putative 0.0079 0.026 0.0381
Echinococcus multilocularis N chimaerin 0.0078 0.0248 0.0021
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0483 0.0483
Entamoeba histolytica SH2-protein kinase domain containing protein 0.01 0.0483 0.3012
Schistosoma mansoni tyrosine kinase 0.0175 0.1297 0.1094
Brugia malayi protein-tyrosine kinase 0.01 0.0483 0.0261
Loa Loa (eye worm) hypothetical protein 0.0076 0.0227 0.0227
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0078 0.0248 0.0021
Echinococcus granulosus para nitrobenzyl esterase 0.0167 0.1202 0.0997
Loa Loa (eye worm) hypothetical protein 0.0078 0.0248 0.0248
Echinococcus multilocularis tyrosine protein kinase shark 0.01 0.0483 0.0261
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0175 0.1297 0.1094
Brugia malayi hypothetical protein 0.0167 0.1202 0.0997
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0155 0.1075 0.1317
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0155 0.1075 0.1254
Loa Loa (eye worm) hypothetical protein 0.0078 0.0248 0.0248
Loa Loa (eye worm) SH2 domain-containing protein 0.0078 0.0248 0.0248
Echinococcus granulosus hexokinase 0.008 0.0274 0.0047
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0536 0.517 0.5057
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.01 0.0483 0.0261
Schistosoma mansoni trans-prenyltransferase 0.0155 0.1075 0.0867
Plasmodium vivax vacuolar-type H+ pumping pyrophosphatase, putative 0.0675 0.6663 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0175 0.1297 0.1094
Echinococcus granulosus NCK adaptor protein 0.0154 0.1062 0.0855
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0235 0.1935 0.1935
Echinococcus granulosus SH2 motif 0.0078 0.0248 0.0021
Brugia malayi Carboxylesterase family protein 0.0167 0.1202 0.0997
Loa Loa (eye worm) hypothetical protein 0.0076 0.0227 0.0227
Schistosoma mansoni SH2A 0.0078 0.0248 0.0021
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0155 0.1075 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.0078 0.0248 0.0021
Echinococcus granulosus expressed conserved protein 0.0078 0.0248 0.0021
Brugia malayi cytokine inducible SH2-containing protein 5 0.0078 0.0248 0.0021
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0078 0.0248 0.0248
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0175 0.1297 0.1094
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0235 0.1935 0.1747
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0167 0.1202 0.0997
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0155 0.1075 0.1254
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0175 0.1297 0.1094
Schistosoma mansoni growth factor receptor-bound protein 0.0154 0.1062 0.0855
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0536 0.517 1
Onchocerca volvulus 0.01 0.0483 0.2619
Echinococcus multilocularis c src tyrosine kinase 0.0175 0.1297 0.1094
Brugia malayi Polyprenyl synthetase family protein 0.0155 0.1075 0.0867
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0078 0.0248 0.0021
Loa Loa (eye worm) hypothetical protein 0.0078 0.0248 0.0248
Echinococcus granulosus SH2 domain containing protein 7 0.0078 0.0248 0.0021
Loa Loa (eye worm) hypothetical protein 0.0167 0.1202 0.1202
Echinococcus multilocularis tyrosine protein kinase Srms 0.01 0.0483 0.0261
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0078 0.0248 0.0021
Loa Loa (eye worm) thyroid receptor interactor 0.0076 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0078 0.0248 0.0248
Echinococcus multilocularis hexokinase 0.008 0.0274 0.0047
Echinococcus multilocularis SH2 motif 0.0078 0.0248 0.0021
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0167 0.1202 0.031
Loa Loa (eye worm) hypothetical protein 0.0167 0.1202 0.1202
Leishmania major polyprenyl synthase, putative 0.0235 0.1935 0.2654
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0078 0.0248 0.0248
Echinococcus multilocularis SH2 domain containing protein 7 0.0078 0.0248 0.0021
Loa Loa (eye worm) hypothetical protein 0.01 0.0483 0.0483
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0155 0.1075 0.0867
Brugia malayi Tyrosine-protein kinase abl-1 0.0175 0.1297 0.1094
Brugia malayi Polyprenyl synthetase family protein 0.0536 0.517 0.5057
Toxoplasma gondii V-type H(+)-translocating pyrophosphatase VP1 0.0675 0.6663 1
Onchocerca volvulus 0.0167 0.1202 1
Echinococcus granulosus BC026374 protein S09 family 0.0167 0.1202 0.0997
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0175 0.1297 0.1094
Echinococcus granulosus acetylcholinesterase 0.0986 1 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0175 0.1297 0.1094
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0078 0.0248 0.0021
Schistosoma mansoni vav2 0.0078 0.0248 0.0021
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0154 0.1062 0.1062
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0483 0.0483
Loa Loa (eye worm) hexokinase type II 0.008 0.0274 0.0274
Brugia malayi SH2 domain containing protein 0.0078 0.0248 0.0021
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0155 0.1075 0.0867
Brugia malayi RhoGAP domain containing protein 0.0078 0.0248 0.0021
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0078 0.0248 0.0021
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0483 0.0483
Brugia malayi Hexokinase family protein 0.008 0.0274 0.0047
Brugia malayi Variant SH3 domain containing protein 0.0154 0.1062 0.0855
Schistosoma mansoni tensin 0.0078 0.0248 0.0021
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0536 0.517 1
Schistosoma mansoni tensin-related 0.0078 0.0248 0.0021
Loa Loa (eye worm) guanylate kinase 0.0076 0.0227 0.0227
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0536 0.517 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0167 0.1202 0.031
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0536 0.517 0.768
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0155 0.1075 0.1317
Leishmania major solanesyl-diphosphate synthase, putative 0.0155 0.1075 0.1317
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0175 0.1297 0.1094
Brugia malayi SH2 domain containing protein 0.0078 0.0248 0.0021
Loa Loa (eye worm) hypothetical protein 0.0076 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0078 0.0248 0.0248
Onchocerca volvulus 0.01 0.0483 0.2619
Loa Loa (eye worm) hypothetical protein 0.0167 0.1202 0.1202
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0154 0.1062 0.1062
Loa Loa (eye worm) hypothetical protein 0.0076 0.0227 0.0227
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0167 0.1202 0.0997
Loa Loa (eye worm) carboxylesterase 0.0167 0.1202 0.1202
Loa Loa (eye worm) hypothetical protein 0.0078 0.0248 0.0248
Brugia malayi hexokinase 0.008 0.0274 0.0047
Trypanosoma cruzi Vacuolar proton pyrophosphatase 1, putative 0.0675 0.6663 1
Echinococcus granulosus tyrosine kinase 0.01 0.0483 0.0261
Echinococcus multilocularis hexokinase type 2 0.008 0.0274 0.0047
Loa Loa (eye worm) protein-tyrosine kinase 0.0076 0.0227 0.0227
Echinococcus multilocularis SHC transforming protein 3 0.0078 0.0248 0.0021
Leishmania major vacuolar-type proton translocating pyrophosphatase 1, putative 0.0675 0.6663 1
Schistosoma mansoni shc transforming protein 0.0078 0.0248 0.0021
Trypanosoma brucei hexokinase 0.008 0.0274 0.0072
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0422 0.3939 0.3798
Brugia malayi SH2 domain containing protein 0.01 0.0483 0.0261
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0076 0.0227 0.0227
Echinococcus granulosus hexokinase type 2 0.008 0.0274 0.0047
Loa Loa (eye worm) TK/ABL protein kinase 0.01 0.0483 0.0483
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0078 0.0248 0.0021
Onchocerca volvulus 0.008 0.0274 0.0475
Schistosoma mansoni acetylcholinesterase 0.0167 0.1202 0.0997
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0167 0.1202 0.0997
Loa Loa (eye worm) hypothetical protein 0.0078 0.0248 0.0248
Trypanosoma brucei hexokinase 0.008 0.0274 0.0072
Echinococcus granulosus tyrosine protein kinase Fyn 0.0175 0.1297 0.1094
Onchocerca volvulus 0.008 0.0274 0.0475
Brugia malayi hypothetical protein 0.0078 0.0248 0.0021
Echinococcus granulosus tyrosine protein kinase ABL1 0.01 0.0483 0.0261
Echinococcus multilocularis acetylcholinesterase 0.0986 1 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0248 0.0248
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0155 0.1075 1
Trypanosoma cruzi polyprenyl synthase, putative 0.0235 0.1935 0.2654
Brugia malayi SH2 domain containing protein 0.0078 0.0248 0.0021
Brugia malayi Carboxylesterase family protein 0.0167 0.1202 0.0997
Onchocerca volvulus 0.0078 0.0248 0.0213
Loa Loa (eye worm) hypothetical protein 0.0167 0.1202 0.1202
Onchocerca volvulus 0.0078 0.0248 0.0213
Onchocerca volvulus 0.01 0.0483 0.2619
Brugia malayi tRNA modification GTPase TrmE family protein 0.0078 0.0248 0.0021
Loa Loa (eye worm) SRC-1 0.0175 0.1297 0.1297
Brugia malayi Protein kinase domain containing protein 0.01 0.0483 0.0261
Plasmodium falciparum V-type K+-independent H+-translocating inorganic pyrophosphatase 0.0675 0.6663 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0167 0.1202 0.0997
Trypanosoma brucei hexokinase, putative 0.008 0.0274 0.0072
Leishmania major hexokinase, putative 0.008 0.0274 0.0072
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0078 0.0248 0.0021
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0167 0.1202 0.0997
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0155 0.1075 0.5
Brugia malayi Protein kinase domain containing protein 0.01 0.0483 0.0261
Schistosoma mansoni tensin-related 0.0078 0.0248 0.0021
Loa Loa (eye worm) hypothetical protein 0.0154 0.1062 0.1062
Echinococcus granulosus hypothetical protein 0.0078 0.0248 0.0021
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0235 0.1935 0.1747
Schistosoma mansoni tyrosine kinase 0.0175 0.1297 0.1094
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0155 0.1075 0.1254
Loa Loa (eye worm) polyprenyl synthetase 0.0155 0.1075 0.1075
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0155 0.1075 1
Entamoeba histolytica hexokinase 1 0.008 0.0274 0.0546
Echinococcus multilocularis tyrosine protein kinase Fyn 0.01 0.0483 0.0261
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0235 0.1935 0.1747
Leishmania major hexokinase, putative 0.008 0.0274 0.0072
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0235 0.1935 0.1747
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0078 0.0248 0.0021
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0536 0.517 1
Schistosoma mansoni signal transduction protein lnk-related 0.0078 0.0248 0.0021
Echinococcus multilocularis para nitrobenzyl esterase 0.0167 0.1202 0.0997
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0536 0.517 0.7663
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0078 0.0248 0.0021
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0078 0.0248 0.0248
Brugia malayi hypothetical protein 0.01 0.0483 0.0261
Brugia malayi Protein kinase domain containing protein 0.01 0.0483 0.0261
Echinococcus granulosus suppressor of cytokine signaling 7 0.0078 0.0248 0.0021
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0536 0.517 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0078 0.0248 0.0021
Echinococcus multilocularis acetylcholinesterase 0.0986 1 1
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0078 0.0248 0.0213
Echinococcus multilocularis hexokinase 0.008 0.0274 0.0047
Onchocerca volvulus 0.0167 0.1202 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0175 0.1297 0.1094
Brugia malayi SRC-1 0.0175 0.1297 0.1094
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0155 0.1075 0.1317
Echinococcus granulosus signal transduction protein lnk realted 0.0078 0.0248 0.0021
Loa Loa (eye worm) hypothetical protein 0.0078 0.0248 0.0248
Loa Loa (eye worm) STAT protein 0.0078 0.0248 0.0248
Brugia malayi Carboxylesterase family protein 0.0167 0.1202 0.0997
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0422 0.3939 0.3798
Trypanosoma cruzi polyprenyl synthase, putative 0.0235 0.1935 0.2654
Loa Loa (eye worm) acetylcholinesterase 1 0.0986 1 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0079 0.026 0.0381
Echinococcus granulosus tyrosine kinase 0.01 0.0483 0.0261
Loa Loa (eye worm) hypothetical protein 0.0167 0.1202 0.1202
Brugia malayi Variant SH3 domain containing protein 0.0154 0.1062 0.0855
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0536 0.517 0.7663
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0175 0.1297 0.1094
Loa Loa (eye worm) hypothetical protein 0.0167 0.1202 0.1202
Loa Loa (eye worm) hypothetical protein 0.0076 0.0227 0.0227
Trichomonas vaginalis spcc417.12 protein, putative 0.0167 0.1202 0.1972
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0536 0.517 1
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0078 0.0248 0.0021

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.0000000015 M Growth response in cultures of MCF-7 (human breast cancer cell line) cells ChEMBL. 9357533
Ka (binding) = 278000000000 M-1 Estrogen receptor (ER) binding affinity ChEMBL. 9357533

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 9357533

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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