Detailed information for compound 1469493

Basic information

Technical information
  • TDR Targets ID: 1469493
  • Name: (E)-2-cyano-3-(3,4-dimethoxyphenyl)-N-(thioph en-2-ylmethyl)prop-2-enamide
  • MW: 328.386 | Formula: C17H16N2O3S
  • H donors: 1 H acceptors: 2 LogP: 2.71 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C(=C\c1ccc(c(c1)OC)OC)/C(=O)NCc1cccs1
  • InChi: 1S/C17H16N2O3S/c1-21-15-6-5-12(9-16(15)22-2)8-13(10-18)17(20)19-11-14-4-3-7-23-14/h3-9H,11H2,1-2H3,(H,19,20)/b13-8+
  • InChiKey: SKXRMMRKWREEBX-MDWZMJQESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-cyano-3-(3,4-dimethoxyphenyl)-N-(thiophen-2-ylmethyl)prop-2-enamide
  • (E)-2-cyano-3-(3,4-dimethoxyphenyl)-N-(2-thienylmethyl)prop-2-enamide
  • 2-cyano-3-(3,4-dimethoxyphenyl)-N-(2-thienylmethyl)prop-2-enamide
  • (E)-2-cyano-3-(3,4-dimethoxyphenyl)-N-(2-thienylmethyl)acrylamide
  • 2-cyano-3-(3,4-dimethoxyphenyl)-N-(2-thienylmethyl)acrylamide
  • MLS000566978
  • SMR000177361
  • 2-Cyano-3-(3,4-dimethoxy-phenyl)-N-thiophen-2-ylmethyl-acrylamide
  • ZINC00270353
  • BAS 02102978

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3494 0.3494
Loa Loa (eye worm) hypothetical protein 0.0035 0.0241 0.0241
Trichomonas vaginalis CAMK family protein kinase 0.1046 1 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0019 0.0093 0.5
Trichomonas vaginalis CAMK family protein kinase 0.1046 1 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0153 0.0153
Leishmania major importin beta-1 subunit, putative 0.0028 0.0178 0.0085
Echinococcus multilocularis 0.0019 0.0093 0.0093
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0438 0.0438
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0187 0.0187
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.1046 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0187 0.0094
Brugia malayi MH2 domain containing protein 0.0144 0.1297 0.1297
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0019 0.0093 0.5
Trypanosoma brucei cytochrome P450, putative 0.0029 0.0187 0.0181
Brugia malayi RNA, U transporter 1 0.0099 0.0861 0.0861
Giardia lamblia Kinase, PLK 0.1046 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0187 0.0094
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0178 0.0026
Onchocerca volvulus Serine\/threonine kinase homolog 0.1046 1 0.5
Trypanosoma cruzi polo-like protein kinase, putative 0.1046 1 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0153 0.0153
Brugia malayi Cytochrome P450 family protein 0.0029 0.0187 0.0187
Loa Loa (eye worm) cytochrome P450 0.0019 0.0093 0.0093
Plasmodium vivax importin-beta 2, putative 0.0035 0.0241 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0153 0.0146
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0178 0.0026
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0153 0.006
Entamoeba histolytica serine/threonine protein kinase, putative 0.1046 1 1
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0178 0.0026
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0241 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0019 0.0093 0.5
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0153 0.006
Schistosoma mansoni cytochrome P450 0.0019 0.0093 0.0093
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0241 0.0235
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.1046 1 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.1046 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0438 0.0438
Trypanosoma brucei polo-like protein kinase 0.1046 1 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0019 0.0093 0.5
Trichomonas vaginalis CAMK family protein kinase 0.1046 1 1
Trypanosoma cruzi polo-like protein kinase, putative 0.1046 1 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0019 0.0093 0.5
Trichomonas vaginalis CAMK family protein kinase 0.1046 1 1
Leishmania major cytochrome p450-like protein 0.0029 0.0187 0.0094
Echinococcus granulosus snurportin 1 0.0372 0.3494 0.3494
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0499 0.0499
Brugia malayi Cytochrome P450 family protein 0.0062 0.0499 0.0499
Brugia malayi Cytochrome P450 family protein 0.0019 0.0093 0.0093
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0019 0.0093 0.5
Entamoeba histolytica hypothetical protein 0.0028 0.0178 0.0026
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0438 0.0438
Trichomonas vaginalis CAMK family protein kinase 0.1046 1 1
Schistosoma mansoni importin beta-1 0.0035 0.0241 0.0241
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.0093 0.0087
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0019 0.0093 0.5
Schistosoma mansoni ran 0.0026 0.0153 0.0153
Plasmodium falciparum importin beta, putative 0.0035 0.0241 1
Mycobacterium leprae putative cytochrome p450 0.0019 0.0093 0.5
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0019 0.0093 0.5
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0355 0.3332 0.3332
Trichomonas vaginalis CAMK family protein kinase 0.1046 1 1
Echinococcus multilocularis snurportin 1 0.0372 0.3494 0.3494
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0019 0.0093 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0438 0.0438
Schistosoma mansoni hypothetical protein 0.0019 0.0093 0.0093
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1297 0.1297
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0019 0.0093 0.5
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0241 0.0235
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0019 0.0093 0.5
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0019 0.0093 0.5
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0019 0.0093 0.5
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0019 0.0093 0.5
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0029 0.0187 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0438 0.0438
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0438 0.0438
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0153 0.4
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0019 0.0093 0.5
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0019 0.0093 0.5
Mycobacterium leprae Conserved hypothetical protein 0.0019 0.0093 0.5
Loa Loa (eye worm) CYP4Cod1 0.0029 0.0187 0.0187
Leishmania major GTP-binding protein, putative 0.0026 0.0153 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0444 0.4188 0.4098
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0438 0.0438
Schistosoma mansoni hypothetical protein 0.0372 0.3494 0.3494
Brugia malayi Cytochrome P450 family protein 0.0029 0.0187 0.0187
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0153 0.0153
Trichomonas vaginalis CAMK family protein kinase 0.0444 0.4188 0.4098
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0019 0.0093 0.5
Echinococcus granulosus serine:threonine protein kinase PLK1 0.1046 1 1
Schistosoma mansoni serine/threonine protein kinase 0.1046 1 1
Brugia malayi Importin beta-1 subunit 0.0035 0.0241 0.0241
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0019 0.0093 0.5
Trichomonas vaginalis CAMK family protein kinase 0.1046 1 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0019 0.0093 0.5
Brugia malayi cytochrome P450 0.0019 0.0093 0.0093
Schistosoma mansoni ran 0.0026 0.0153 0.0153
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0241 0.0241
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1297 0.1297
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0019 0.0093 0.5
Schistosoma mansoni kinase 0.0957 0.9144 0.9144
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0187 0.0187
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0438 0.0438
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0153 0.0153
Echinococcus granulosus importin subunit beta 1 0.0035 0.0241 0.0241
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0093 0.0093
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0355 0.3332 0.3332
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0438 0.0438
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0178 0.0085

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3548 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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