Detailed information for compound 1479529

Basic information

Technical information
  • TDR Targets ID: 1479529
  • Name: [1-[(E)-2-methyl-3-phenylprop-2-enyl]piperidi n-4-yl]-piperidin-1-ylmethanone
  • MW: 326.476 | Formula: C21H30N2O
  • H donors: 0 H acceptors: 1 LogP: 3.82 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C(=C\c1ccccc1)/CN1CCC(CC1)C(=O)N1CCCCC1
  • InChi: 1S/C21H30N2O/c1-18(16-19-8-4-2-5-9-19)17-22-14-10-20(11-15-22)21(24)23-12-6-3-7-13-23/h2,4-5,8-9,16,20H,3,6-7,10-15,17H2,1H3/b18-16+
  • InChiKey: MSZOTFGJKQSETK-FBMGVBCBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1-(2-methyl-3-phenylprop-2-enyl)piperidin-4-yl]-piperidin-1-ylmethanone
  • [1-[(E)-2-methyl-3-phenyl-prop-2-enyl]-4-piperidyl]-(1-piperidyl)methanone
  • [1-(2-methyl-3-phenyl-prop-2-enyl)-4-piperidyl]-(1-piperidyl)methanone
  • [1-[(E)-2-methyl-3-phenylprop-2-enyl]-4-piperidinyl]-(1-piperidyl)methanone
  • [1-(2-methyl-3-phenylprop-2-enyl)-4-piperidinyl]-(1-piperidyl)methanone
  • [1-(2-methyl-3-phenyl-prop-2-enyl)-4-piperidyl]-piperidino-methanone
  • [1-[(E)-2-methyl-3-phenyl-prop-2-enyl]-4-piperidyl]-piperidino-methanone
  • [1-(2-methyl-3-phenyl-prop-2-enyl)piperidin-4-yl]-piperidin-1-yl-methanone
  • [1-[(E)-2-methyl-3-phenyl-prop-2-enyl]piperidin-4-yl]-piperidin-1-yl-methanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0306 0.0143 0.1684
Trichomonas vaginalis PIKK family atypical protein kinase 0.1288 0.0767 0.9832
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1288 0.0767 0.9834
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0266 0.0118 0.4407
Loa Loa (eye worm) phosphatidylinositol 3 0.0266 0.0118 0.1449
Echinococcus granulosus plexin a4 0.0747 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0368 0.0183 0.2247
Echinococcus multilocularis Zinc finger, PHD finger 0.0377 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0731 0.0413 0.5089
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1122 0.0662 0.8442
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1152 0.0681 0.0681
Plasmodium vivax glutathione S-transferase, putative 0.0199 0.0075 0.3494
Brugia malayi Probable exocyst complex component Sec5 0.0116 0.0022 0.0277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0755 0.0429 0.5365
Echinococcus granulosus epidermal growth factor receptor 0.0341 0.0165 0.0165
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1353 0.0808 0.897
Schistosoma mansoni vesicular amine transporter 0.0086 0.0004 0.0037
Leishmania major phosphatidylinositol 4-kinase, putative 0.0266 0.0118 0.0287
Schistosoma mansoni fkbp-rapamycin associated protein 0.0715 0.0403 0.4475
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0266 0.0118 0.0118
Onchocerca volvulus 0.0266 0.0118 0.2781
Loa Loa (eye worm) hypothetical protein 0.0264 0.0117 0.1436
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0298 0.0138 0.036
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0731 0.0413 0.5114
Echinococcus multilocularis exocyst complex component 2 0.0116 0.0022 0.0022
Onchocerca volvulus 0.0264 0.0117 0.2747
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1353 0.0808 0.231
Loa Loa (eye worm) hypothetical protein 0.1219 0.0723 0.8904
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0266 0.0118 0.5931
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0376 0.0188 0.2325
Trypanosoma cruzi target of rapamycin kinase 3 0.1288 0.0767 0.2191
Trichomonas vaginalis PIKK family atypical protein kinase 0.1288 0.0767 0.9832
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0266 0.0118 0.1456
Schistosoma mansoni semaphorin 5-related 0.0264 0.0117 0.1291
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0377 0.0189 0.0484
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1308 0.078 0.078
Brugia malayi hypoxia-induced factor 1 0.0155 0.0047 0.0583
Loa Loa (eye worm) TK/EGFR protein kinase 0.0341 0.0165 0.2035
Trichomonas vaginalis conserved hypothetical protein 0.045 0.0235 0.2801
Echinococcus multilocularis glutathione S-transferase 0.0473 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0087 0.0004 0.0052
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0266 0.0118 0.1258
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0377 0.0189 0.2196
Echinococcus granulosus twitchin 0.0094 0.0008 0.0008
Echinococcus granulosus epidermal growth factor receptor 0.0202 0.0077 0.0077
Schistosoma mansoni tyrosine kinase 0.0159 0.005 0.0552
Loa Loa (eye worm) phosphatidylinositol 3 0.0266 0.0118 0.1449
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0747 0.0424 0.47
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1122 0.0662 0.8442
Schistosoma mansoni nephrin 0.0094 0.0008 0.009
Entamoeba histolytica hypothetical protein 0.0266 0.0118 0.1258
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0715 0.0403 0.1132
Loa Loa (eye worm) sema domain-containing protein 0.0264 0.0117 0.1436
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0377 0.0189 0.0189
Schistosoma mansoni lipoxygenase 0.0125 0.0028 0.0312
Schistosoma mansoni fibrocystin l 0.0116 0.0022 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.1263 0.0751 0.9621
Trichomonas vaginalis conserved hypothetical protein 0.0793 0.0453 0.5683
Schistosoma mansoni hypothetical protein 0.0116 0.0022 0.0245
Echinococcus multilocularis glutathione S transferase 0.0348 0.017 0.017
Echinococcus granulosus glutathione S transferase 0.0348 0.017 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.1283 0.0764 0.9789
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1308 0.078 0.078
Trichomonas vaginalis glutaminyl-tRNA synthetase, putative 0.0125 0.0028 0.0076
Loa Loa (eye worm) phosphatidylinositol kinase 0.0266 0.0118 0.1449
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0377 0.0189 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.1283 0.0764 0.9789
Brugia malayi Cytochrome P450 family protein 0.0117 0.0023 0.0289
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0266 0.0118 0.0301
Loa Loa (eye worm) hypothetical protein 0.0632 0.035 0.4312
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0266 0.0118 0.1303
Schistosoma mansoni plexin 0.0632 0.035 0.3885
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0908 0.0526 0.6648
Schistosoma mansoni cell adhesion molecule 0.0087 0.0004 0.0043
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0747 0.0424 0.5347
Echinococcus multilocularis eukaryotic translation elongation factor 1 0.0103 0.0014 0.0014
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0517 0.0277 0.3432
Trichomonas vaginalis PIKK family atypical protein kinase 0.076 0.0432 0.5407
Trichomonas vaginalis PIKK family atypical protein kinase 0.1308 0.078 1
Loa Loa (eye worm) hypothetical protein 0.0081 0 0.0004
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0528 0.0284 0.0284
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1499 0.0901 0.0901
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0377 0.0189 0.0189
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0517 0.0277 0.3437
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0377 0.0189 0.743
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0983 0.0573 0.7272
Loa Loa (eye worm) hypothetical protein 0.0391 0.0197 0.2431
Brugia malayi FAT domain containing protein 0.0528 0.0284 0.3515
Trichomonas vaginalis PIKK family atypical protein kinase 0.1283 0.0764 0.9789
Brugia malayi hypothetical protein 0.0264 0.0117 0.1443
Trichomonas vaginalis PIKK family atypical protein kinase 0.1263 0.0751 0.9621
Echinococcus multilocularis prostaglandin H2 D isomerase 0.0199 0.0075 0.0075
Echinococcus multilocularis epidermal growth factor receptor 0.0341 0.0165 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0838 0.0482 0.6061
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0235 0.0098 0.0098
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0266 0.0118 0.1381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0715 0.0403 0.5029
Schistosoma mansoni hypothetical protein 0.0264 0.0117 0.1291
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0482 0.0255 0.07
Trichomonas vaginalis PIKK family atypical protein kinase 0.1268 0.0755 0.9664
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1308 0.078 0.2123
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0235 0.0098 0.0098
Loa Loa (eye worm) phosphatidylinositol 3 0.1359 0.0812 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1263 0.0751 0.9622
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0592 0.0325 0.3991
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0266 0.0118 0.1381
Loa Loa (eye worm) hypothetical protein 0.0081 0 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.5514 0.3452 1
Schistosoma mansoni hypothetical protein 0.0264 0.0117 0.1291
Echinococcus multilocularis glutathione s transferase mu 0.0473 0.0249 0.0249
Onchocerca volvulus 0.0277 0.0125 0.3008
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1243 0.0739 0.946
Echinococcus multilocularis roundabout 2 0.01 0.0012 0.0012
Schistosoma mansoni lipoxygenase 0.0235 0.0098 0.1083
Schistosoma mansoni tyrosine kinase 0.0137 0.0036 0.0394
Trichomonas vaginalis PIKK family atypical protein kinase 0.1288 0.0767 0.9832
Entamoeba histolytica hypothetical protein 0.0266 0.0118 0.1258
Trichomonas vaginalis PIKK family atypical protein kinase 0.045 0.0235 0.2801
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0377 0.0189 0.2323
Mycobacterium leprae conserved hypothetical protein 0.0266 0.0118 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1243 0.0739 0.9454
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1308 0.078 1
Echinococcus multilocularis glutathione S transferase 0.0398 0.0202 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.1266 0.0753 0.965
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0202 0.0077 0.0077
Entamoeba histolytica hypothetical protein 0.0266 0.0118 0.1258
Trichomonas vaginalis PIKK family atypical protein kinase 0.1263 0.0751 0.9622
Brugia malayi Plexin repeat family protein 0.0632 0.035 0.4334
Echinococcus multilocularis glutathione S transferase 0.0473 0.0249 0.0249
Brugia malayi hypothetical protein 0.0264 0.0117 0.1443
Loa Loa (eye worm) hypothetical protein 0.0264 0.0117 0.1436
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.582 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0266 0.0118 0.1258
Brugia malayi Protein kinase domain containing protein 0.0137 0.0036 0.0443
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0266 0.0118 0.1258
Loa Loa (eye worm) hypothetical protein 0.0715 0.0403 0.4966
Loa Loa (eye worm) TK/INSR protein kinase 0.0137 0.0036 0.0441
Loa Loa (eye worm) hypothetical protein 0.0528 0.0284 0.3497
Schistosoma mansoni hypothetical protein 0.0528 0.0284 0.3151
Trichomonas vaginalis PIKK family atypical protein kinase 0.1308 0.078 1
Echinococcus multilocularis 0.0266 0.0118 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.1263 0.0751 0.9622
Loa Loa (eye worm) hypothetical protein 0.0081 0 0.0004
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1288 0.0767 0.2088
Loa Loa (eye worm) hypothetical protein 0.0125 0.0028 0.0346
Schistosoma mansoni tyrosine kinase 0.0202 0.0077 0.0854
Schistosoma mansoni tyrosine kinase 0.0341 0.0165 0.1832
Loa Loa (eye worm) phosphatidylinositol 3 0.0266 0.0118 0.1449
Echinococcus granulosus neuroglian 0.0094 0.0008 0.0008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1308 0.078 0.965
Echinococcus granulosus glutathione s transferase mu 0.0473 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0264 0.0117 0.1436
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0769 0.0437 0.4826
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0377 0.0189 0.2196
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1308 0.078 0.2227
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0793 0.0453 0.5851
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0377 0.0189 0.2196
Loa Loa (eye worm) hypothetical protein 0.0482 0.0255 0.3137
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0715 0.0403 0.0403
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0266 0.0118 0.0118
Echinococcus granulosus semaphorin 5B 0.0264 0.0117 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0286 0.013 0.1426
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0266 0.0118 0.1456
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1308 0.078 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.078 0.0445 0.5575
Echinococcus multilocularis hypothetical protein 0.0264 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0264 0.0117 0.1436
Schistosoma mansoni voltage-gated potassium channel 0.0088 0.0005 0.0048
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1308 0.078 0.2227
Leishmania major phosphatidylinositol kinase, putative 0.0266 0.0118 0.0287
Echinococcus multilocularis glutathione S transferase 0.0348 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0116 0.0022 0.0275
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1353 0.0808 0.231
Brugia malayi hypothetical protein 0.0081 0 0.0004
Leishmania major hypothetical protein, unknown function 0.0266 0.0118 0.0287
Echinococcus granulosus transcription factor collier 0.0116 0.0022 0.0022
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1353 0.0808 1
Brugia malayi hypothetical protein 0.0168 0.0055 0.0685
Brugia malayi Sema domain containing protein 0.0264 0.0117 0.1443
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0377 0.0189 0.2279
Onchocerca volvulus 0.0632 0.035 1
Brugia malayi Fibronectin type III domain containing protein 0.0081 0 0.0004
Mycobacterium ulcerans short chain dehydrogenase 0.0629 0.0348 0.5
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0405 0.0206 0.1339
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1122 0.0662 0.819
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0377 0.0189 0.2328
Loa Loa (eye worm) plexin A 0.0747 0.0424 0.5217
Loa Loa (eye worm) hypothetical protein 0.0081 0 0.0004
Loa Loa (eye worm) hypothetical protein 0.0081 0 0.0004
Loa Loa (eye worm) phosphatidylinositol 3 0.1308 0.078 0.9602
Plasmodium vivax hypothetical protein, conserved 0.0266 0.0118 0.5931
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0266 0.0118 0.0301
Brugia malayi DNA-binding protein LAG-1 0.0116 0.0022 0.0277
Schistosoma mansoni elongation factor 1-gamma 0.0103 0.0014 0.0154
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0377 0.0189 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1288 0.0767 0.9832
Trichomonas vaginalis PIKK family atypical protein kinase 0.1268 0.0755 0.9664
Brugia malayi IPT/TIG domain containing protein 0.0116 0.0022 0.0277
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1308 0.078 0.8656
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0377 0.0189 0.0189
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0517 0.0277 0.3366
Loa Loa (eye worm) phosphatidylinositol 3 0.1266 0.0753 0.9275
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0517 0.0277 0.3366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0755 0.0429 0.5365
Echinococcus multilocularis transcription factor collier 0.0116 0.0022 0.0022
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1353 0.0808 0.0808
Loa Loa (eye worm) hypoxia-induced factor 1 0.0155 0.0047 0.058
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0266 0.0118 0.5931
Trichomonas vaginalis PIKK family atypical protein kinase 0.1243 0.0739 0.9454
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0517 0.0277 0.3366
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0747 0.0424 0.1191
Loa Loa (eye worm) hypothetical protein 0.01 0.0012 0.0151
Schistosoma mansoni hypothetical protein 0.0266 0.0118 0.1303
Loa Loa (eye worm) hypothetical protein 0.0116 0.0022 0.0275
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0377 0.0189 0.2092
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0137 0.0036 0.0036
Echinococcus multilocularis neuroglian 0.0094 0.0008 0.0008
Schistosoma mansoni tyrosine kinase 0.0137 0.0036 0.0394
Schistosoma mansoni GST class-mu 0.0473 0.0249 0.2762
Trichomonas vaginalis PIKK family atypical protein kinase 0.1243 0.0739 0.9454
Loa Loa (eye worm) hypothetical protein 0.0264 0.0117 0.1436
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1266 0.0753 0.205
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0377 0.0189 0.2196
Echinococcus granulosus prostaglandin H2 D isomerase 0.0199 0.0075 0.0075
Leishmania major hypothetical protein, conserved 0.578 0.3621 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0251 0.0109 0.0275
Echinococcus granulosus glutathione S transferase 0.0473 0.0249 0.0249
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0517 0.0277 0.3366
Brugia malayi Furin-like cysteine rich region family protein 0.0341 0.0165 0.2045
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0857 0.0493 0.6214
Onchocerca volvulus Tyrosine kinase homolog 0.0333 0.016 0.4103
Brugia malayi Glutathione S-transferase 4 0.0125 0.0028 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.1243 0.0739 0.9454
Schistosoma mansoni plexin 0.0368 0.0183 0.2023
Echinococcus multilocularis epidermal growth factor receptor 0.0202 0.0077 0.0077
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0747 0.0424 0.5242
Echinococcus multilocularis 0.0093 0.0008 0.0008
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1353 0.0808 0.0808
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0377 0.0189 0.2092
Schistosoma mansoni Glutathione S-transferase 28 kDa (GST 28) (GST class-mu) 0.0199 0.0075 0.0831
Loa Loa (eye worm) hypothetical protein 0.0266 0.0118 0.1449
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0739 0.0418 0.5225
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0266 0.0118 0.4407
Leishmania major phosphatidylinositol kinase related protein, putative 0.0298 0.0138 0.0343
Entamoeba histolytica tyrosin kinase, putative 0.0158 0.005 0.0359
Echinococcus granulosus roundabout 2 0.01 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0116 0.0022 0.0245
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0266 0.0118 0.0301
Plasmodium falciparum glutathione S-transferase 0.0473 0.0249 1
Echinococcus multilocularis glutathione S transferase 0.0199 0.0075 0.0075
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1308 0.078 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0747 0.0424 0.5297
Trichomonas vaginalis PIKK family atypical protein kinase 0.1283 0.0764 0.9789
Loa Loa (eye worm) cytochrome P450 family protein 0.0117 0.0023 0.0287
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1122 0.0662 0.1884
Loa Loa (eye worm) hypothetical protein 0.0081 0 0.0004
Onchocerca volvulus 0.0266 0.0118 0.2781
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1308 0.078 1
Echinococcus multilocularis glutathione S transferase 0.0473 0.0249 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0755 0.0429 0.5365
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.1308 0.078 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0407 0.0208 0.2555
Schistosoma mansoni glutathione-S-transferase 0.0473 0.0249 0.2762
Trichomonas vaginalis PIKK family atypical protein kinase 0.0266 0.0118 0.1258
Echinococcus granulosus glutathione S transferase 0.0348 0.017 0.017
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0517 0.0277 0.0766
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1499 0.0901 0.0901
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0517 0.0277 0.3076
Trichomonas vaginalis PIKK family atypical protein kinase 0.1263 0.0751 0.9621
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0715 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0116 0.0022 0.0275
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0377 0.0189 0.2328
Echinococcus multilocularis glutathione S transferase 0.0398 0.0202 0.0202
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1122 0.0662 0.1884
Echinococcus granulosus glutathione S transferase Mu 1 0.0199 0.0075 0.0075
Schistosoma mansoni tyrosine kinase 0.0159 0.005 0.0552
Echinococcus granulosus eukaryotic translation elongation factor 1 0.0103 0.0014 0.0014
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0137 0.0036 0.0036
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0517 0.0277 0.3366
Loa Loa (eye worm) hypothetical protein 0.01 0.0012 0.0151
Schistosoma mansoni tyrosine kinase 0.0202 0.0077 0.0854
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0266 0.0118 0.0301
Entamoeba histolytica protein kinase domain containing protein 0.0158 0.005 0.0359
Brugia malayi glutathione transferase 0.1219 0.0723 0.8949
Trichomonas vaginalis PIKK family atypical protein kinase 0.1283 0.0764 0.9789
Schistosoma mansoni tyrosine kinase 0.0159 0.005 0.0552
Loa Loa (eye worm) phosphatidylinositol 3 0.0266 0.0118 0.1449
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0715 0.0403 0.4991
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1122 0.0662 0.8442
Toxoplasma gondii FATC domain-containing protein 0.0747 0.0424 0.5461
Echinococcus granulosus semaphorin 1A 0.0264 0.0117 0.0117
Echinococcus multilocularis serine protein kinase ATM 0.0747 0.0424 0.0424
Trichomonas vaginalis PIKK family atypical protein kinase 0.1263 0.0751 0.9622
Schistosoma mansoni hypothetical protein 0.0368 0.0183 0.2023
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0813 0.0466 0.5895
Loa Loa (eye worm) hypothetical protein 0.0116 0.0022 0.0275
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1499 0.0901 1
Entamoeba histolytica hypothetical protein 0.0983 0.0573 0.7272
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0266 0.0118 0.1381
Entamoeba histolytica hypothetical protein 0.0747 0.0424 0.5297
Echinococcus granulosus insulin receptor 0.0137 0.0036 0.0036
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0377 0.0189 0.2335
Loa Loa (eye worm) hypothetical protein 0.0168 0.0055 0.0682
Echinococcus granulosus exocyst complex component 2 0.0116 0.0022 0.0022
Brugia malayi Sema domain containing protein 0.0264 0.0117 0.1443
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1122 0.0662 0.8442
Loa Loa (eye worm) phosphatidylinositol 3 0.0251 0.0109 0.1337
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0266 0.0118 0.0118
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0266 0.0118 0.5931
Leishmania major phosphatidylinositol 3-kinase, putative 0.0377 0.0189 0.0484
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0266 0.0118 0.1258
Mycobacterium tuberculosis Probable oxidoreductase 0.0629 0.0348 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0908 0.0526 0.6648
Loa Loa (eye worm) hypothetical protein 0.0264 0.0117 0.1436
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1266 0.0753 0.9654
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0266 0.0118 0.1303
Leishmania major phosphatidylinositol 3-kinase, putative 0.1243 0.0739 0.2009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0266 0.0118 0.1456
Toxoplasma gondii target of rapamycin (TOR), putative 0.1283 0.0764 1
Plasmodium vivax hypothetical protein 0.0266 0.0118 0.5931
Brugia malayi plexin A 0.0747 0.0424 0.5243
Entamoeba histolytica protein kinase rad3, putative 0.0715 0.0403 0.5029
Trichomonas vaginalis conserved hypothetical protein 0.0528 0.0284 0.3455
Trichomonas vaginalis PIKK family atypical protein kinase 0.1283 0.0764 0.9789
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0377 0.0189 0.2196
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0266 0.0118 0.1352
Echinococcus multilocularis insulin receptor 0.0137 0.0036 0.0036
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0087 0.0004 0.0004
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0731 0.0413 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.1288 0.0767 0.9832
Echinococcus granulosus serine protein kinase ATM 0.0747 0.0424 0.0424
Echinococcus multilocularis plexin a4 0.0747 0.0424 0.0424
Brugia malayi Immunoglobulin I-set domain containing protein 0.0407 0.0208 0.2568
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0731 0.0413 0.0413
Loa Loa (eye worm) sema domain-containing protein 0.0264 0.0117 0.1436
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0528 0.0284 0.0284
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0266 0.0118 0.0118
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0266 0.0118 0.0118
Echinococcus multilocularis semaphorin 5B 0.0264 0.0117 0.0117
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0377 0.0189 0.0508
Schistosoma mansoni voltage-gated potassium channel 0.0088 0.0005 0.0048
Giardia lamblia GTOR 0.1308 0.078 1
Echinococcus granulosus glutathione S transferase 0.0125 0.0028 0.0028
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0266 0.0118 0.1352
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0266 0.0118 0.1303
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1308 0.078 0.2123
Loa Loa (eye worm) hypothetical protein 0.0793 0.0453 0.5575
Trichomonas vaginalis PIKK family atypical protein kinase 0.0739 0.0418 0.5225
Trichomonas vaginalis PIKK family atypical protein kinase 0.1283 0.0764 0.9789

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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