Detailed information for compound 1482053

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 441.974 | Formula: C23H24ClN3O2S
  • H donors: 2 H acceptors: 2 LogP: 4.33 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)/C=c\1/sc2ccc(cc2[nH]c1=O)C(=O)NCCCN1CCCC1
  • InChi: 1S/C23H24ClN3O2S/c24-18-6-3-5-16(13-18)14-21-23(29)26-19-15-17(7-8-20(19)30-21)22(28)25-9-4-12-27-10-1-2-11-27/h3,5-8,13-15H,1-2,4,9-12H2,(H,25,28)(H,26,29)/b21-14+
  • InChiKey: DFDIBHUZIHUSAX-KGENOOAVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens RAD52 homolog (S. cerevisiae) Starlite/ChEMBL No references
Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis 6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Neospora caninum Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related Get druggable targets OG5_127121 All targets in OG5_127121
Candida albicans likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C) Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma japonicum ko:K00036 glucose-6-phosphate 1-dehydrogenase [EC1.1.1.49], putative Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium knowlesi glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Giardia lamblia DNA repair protein RAD52 Get druggable targets OG5_130806 All targets in OG5_130806
Plasmodium yoelii Glucose-6-phosphate dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Candida albicans similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor Get druggable targets OG5_130806 All targets in OG5_130806
Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma brucei gambiense glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Brugia malayi glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Entamoeba histolytica DNA repair and recombination protein RAD52, putative Get druggable targets OG5_130806 All targets in OG5_130806
Leishmania braziliensis glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Candida albicans likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C) Get druggable targets OG5_127121 All targets in OG5_127121
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania mexicana glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Babesia bovis glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase Get druggable targets OG5_127121 All targets in OG5_127121
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Candida albicans similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor Get druggable targets OG5_130806 All targets in OG5_130806
Trypanosoma congolense glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase Get druggable targets OG5_127121 All targets in OG5_127121
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Theileria parva glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania donovani glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania infantum glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Treponema pallidum glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Neospora caninum Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related Get druggable targets OG5_127121 All targets in OG5_127121
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0145 0.0281 0.0336
Schistosoma mansoni zinc finger protein 0.0063 0.005 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.007 0.007 0.0088
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Brugia malayi Latrophilin receptor protein 2 0.0683 0.1799 0.2389
Schistosoma mansoni hypothetical protein 0.0683 0.1799 0.1796
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Brugia malayi glucose-6-phosphate dehydrogenase 0.0263 0.0614 0.0812
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0127 0.0232 0.5
Brugia malayi nuclear hormone receptor 0.007 0.007 0.0088
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0119 0.0208 0.1774
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.007 0.007 0.0088
Brugia malayi G protein-coupled receptor F59B2.13 0.0236 0.0538 0.0711
Onchocerca volvulus 0.0236 0.0538 0.3138
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0278 0.0658 0.0786
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0273 0.0643 0.0883
Echinococcus granulosus neuropeptide receptor 0.0236 0.0538 0.0639
Schistosoma mansoni protein kinase 0.0138 0.0263 0.0259
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Loa Loa (eye worm) histone deacetylase 0.0074 0.0081 0.0102
Echinococcus granulosus tubulin subunit beta 0.0089 0.0124 0.0143
Echinococcus multilocularis voltage dependent calcium channel 0.0145 0.0281 0.0336
Toxoplasma gondii hypothetical protein 0.0106 0.0173 0.0184
Loa Loa (eye worm) hypothetical protein 0.1512 0.4139 0.5501
Plasmodium falciparum histone deacetylase, putative 0.0074 0.0081 0.0532
Echinococcus multilocularis rhodopsin orphan GPCR 0.0236 0.0538 0.0644
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Echinococcus multilocularis serotonin receptor 0.0236 0.0538 0.0644
Entamoeba histolytica heat shock protein 90, putative 0.0141 0.027 0.1932
Brugia malayi Melatonin receptor type 1A 0.0236 0.0538 0.0711
Echinococcus multilocularis ring and YY1 binding protein 0.0063 0.005 0.0059
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0236 0.0538 0.0534
Schistosoma mansoni amine GPCR 0.0236 0.0538 0.0534
Plasmodium vivax histone deacetylase, putative 0.0074 0.0081 0.0058
Echinococcus granulosus ecdysone induced protein 78C 0.007 0.007 0.0079
Onchocerca volvulus 0.0157 0.0317 0.1836
Loa Loa (eye worm) PAN domain-containing protein 0.0157 0.0317 0.0416
Brugia malayi Histone deacetylase family protein 0.0074 0.0081 0.0102
Loa Loa (eye worm) histone deacetylase 11 0.0074 0.0081 0.0102
Schistosoma mansoni hypothetical protein 0.0077 0.009 0.0086
Loa Loa (eye worm) apoptosis regulator protein 0.032 0.0775 0.1026
Brugia malayi Nuclear hormone receptor family member nhr-3 0.007 0.007 0.0088
Leishmania major heat shock protein 83-1 0.0141 0.027 0.2471
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0091 0.013 0.1545
Leishmania major histone deacetylase, putative 0.0074 0.0081 0.0354
Brugia malayi G-protein coupled receptor 0.0236 0.0538 0.0711
Schistosoma mansoni neuropeptide receptor 0.0236 0.0538 0.0534
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0683 0.1799 0.2389
Trichomonas vaginalis histone deacetylase, putative 0.0074 0.0081 0.0417
Brugia malayi Transforming growth factor beta like domain containing protein 0.0126 0.023 0.03
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0014 0.0011
Echinococcus granulosus neuropeptides capa receptor 0.0236 0.0538 0.0639
Brugia malayi PAN domain containing protein 0.0157 0.0317 0.0416
Loa Loa (eye worm) endoplasmin 0.0141 0.027 0.0353
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0236 0.0538 0.0639
Schistosoma mansoni growth hormone secretagogue receptor 0.0236 0.0538 0.0534
Leishmania major heat shock protein 83-1 0.0141 0.027 0.2471
Loa Loa (eye worm) hypothetical protein 0.0683 0.1799 0.2389
Echinococcus granulosus neuropeptide receptor 0.0236 0.0538 0.0639
Leishmania major heat shock protein 83-1 0.0141 0.027 0.2471
Schistosoma mansoni tubulin subunit beta 0.0089 0.0124 0.012
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0126 0.023 0.027
Trypanosoma brucei histone deacetylase 4 0.0074 0.0081 0.0354
Echinococcus granulosus 7tm_1 domain containing protein 0.0236 0.0538 0.0639
Trichomonas vaginalis histone deacetylase, putative 0.0074 0.0081 0.0417
Leishmania major beta tubulin 0.0089 0.0124 0.0832
Plasmodium vivax endoplasmin, putative 0.0141 0.027 0.3398
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0145 0.0281 0.0336
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0119 0.0208 0.1774
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.012 0.0212 0.0276
Loa Loa (eye worm) hypothetical protein 0.0145 0.0281 0.0368
Schistosoma mansoni amine GPCR 0.0236 0.0538 0.0534
Brugia malayi histone deacetylase 3 (HD3) 0.0074 0.0081 0.0102
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0057 0.0033 0.0029
Toxoplasma gondii hypothetical protein 0.0157 0.0317 0.0398
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0095 0.014 0.0167
Schistosoma mansoni hypothetical protein 0.021 0.0465 0.0461
Leishmania major beta tubulin 0.0089 0.0124 0.0832
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0263 0.0614 1
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0176 0.037 0.0486
Onchocerca volvulus 0.0157 0.0317 0.1836
Onchocerca volvulus 0.0063 0.005 0.0267
Schistosoma mansoni coup transcription factor 0.007 0.007 0.0066
Loa Loa (eye worm) bone morphogenic protein 6 0.0126 0.023 0.03
Onchocerca volvulus 0.0236 0.0538 0.3138
Leishmania major beta tubulin 0.0089 0.0124 0.0832
Trichomonas vaginalis AGC family protein kinase 0.0109 0.018 0.21
Leishmania major beta tubulin 0.0089 0.0124 0.0832
Brugia malayi hypothetical protein 0.0236 0.0538 0.0711
Onchocerca volvulus 0.007 0.007 0.0386
Loa Loa (eye worm) neuropeptide F receptor 0.0236 0.0538 0.0711
Leishmania major heat shock protein 83-1 0.0141 0.027 0.2471
Trichomonas vaginalis histone deacetylase, putative 0.0074 0.0081 0.0417
Loa Loa (eye worm) TK/EGFR protein kinase 0.0146 0.0284 0.0372
Onchocerca volvulus 0.0236 0.0538 0.3138
Echinococcus granulosus rhodopsin orphan GPCR 0.0236 0.0538 0.0639
Echinococcus multilocularis GPCR, family 2 0.0683 0.1799 0.2151
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.007 0.007 0.0066
Echinococcus granulosus orexin receptor type 2 0.0236 0.0538 0.0639
Plasmodium falciparum tubulin beta chain 0.0089 0.0124 0.1251
Schistosoma mansoni tyrosine kinase 0.0077 0.0091 0.0087
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0047 0.0004 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.0622 0.9642
Echinococcus multilocularis jun protein 0.0095 0.014 0.0167
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0236 0.0538 0.0644
Schistosoma mansoni myosin xvIII 0.0236 0.0538 0.0534
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0236 0.0538 0.0534
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0263 0.0614 1
Trichomonas vaginalis histone deacetylase, putative 0.0074 0.0081 0.0417
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Echinococcus multilocularis orexin receptor type 2 0.0236 0.0538 0.0644
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0178 0.0375 0.0448
Trypanosoma brucei beta tubulin 0.0089 0.0124 0.0832
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0273 0.0643 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0119 0.0208 0.1774
Echinococcus granulosus serotonin receptor 0.0236 0.0538 0.0639
Brugia malayi Adenylyl cyclase protein 0.0062 0.0046 0.0056
Onchocerca volvulus 0.0073 0.0078 0.0433
Echinococcus granulosus sex peptide receptor 0.0236 0.0538 0.0639
Schistosoma mansoni alpha-1 adrenergic receptor 0.0236 0.0538 0.0534
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0176 0.037 0.0437
Schistosoma mansoni opsin-like receptor 0.0236 0.0538 0.0534
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.0622 0.9642
Brugia malayi Kringle domain containing protein 0.0073 0.0078 0.0098
Echinococcus multilocularis rhodopsin orphan GPCR 0.0236 0.0538 0.0644
Echinococcus multilocularis allatostatin A receptor 0.065 0.1706 0.204
Onchocerca volvulus 0.0059 0.0039 0.0205
Trypanosoma cruzi beta tubulin, putative 0.0089 0.0124 0.0832
Brugia malayi Furin-like cysteine rich region family protein 0.0146 0.0284 0.0372
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0236 0.0538 0.0644
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.042 0.1057 1
Loa Loa (eye worm) hypothetical protein 0.007 0.007 0.0088
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0087 0.0119 0.0774
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0236 0.0538 0.0644
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0236 0.0538 0.0644
Echinococcus granulosus sodium channel protein 0.0377 0.0938 0.1117
Echinococcus granulosus Tubulin beta 2C chain 0.0089 0.0124 0.0143
Echinococcus multilocularis heat shock protein 0.0141 0.027 0.0322
Schistosoma mansoni histone deacetylase 0.0074 0.0081 0.0077
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0095 0.014 0.0163
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.007 0.007 0.0088
Brugia malayi hypothetical protein 0.0236 0.0538 0.0711
Giardia lamblia Beta tubulin 0.0089 0.0124 0.0436
Schistosoma mansoni histone deacetylase 4 5 0.0074 0.0081 0.0077
Echinococcus granulosus histone deacetylase 1 0.0074 0.0081 0.0092
Echinococcus granulosus SWI:SNF matrix associated 0.0176 0.037 0.0437
Loa Loa (eye worm) hypothetical protein 0.007 0.007 0.0088
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.3009 0.8364 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.007 0.007 0.0066
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0172 0.0357 0.5784
Schistosoma mansoni glutamate receptor NMDA 0.005 0.0014 0.001
Brugia malayi PAN domain containing protein 0.0157 0.0317 0.0416
Echinococcus granulosus heat shock protein 0.0141 0.027 0.0318
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.007 0.007 0.0079
Echinococcus multilocularis tissue type plasminogen activator 0.0073 0.0078 0.0093
Trypanosoma brucei heat shock protein, putative 0.0141 0.027 0.2471
Echinococcus granulosus GPCR family 2 0.0683 0.1799 0.2148
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.007 0.007 0.0084
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Echinococcus multilocularis rhodopsin orphan GPCR 0.0236 0.0538 0.0644
Trypanosoma brucei heat shock protein, putative 0.0141 0.027 0.2471
Schistosoma mansoni hypothetical protein 0.032 0.0775 0.0772
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0683 0.1799 0.2151
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0109 0.018 0.0234
Trypanosoma brucei beta tubulin 0.0089 0.0124 0.0832
Entamoeba histolytica protein kinase, putative 0.0109 0.018 0.101
Leishmania major heat shock protein 83-1 0.0141 0.027 0.2471
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.032 0.0775 0.1026
Trypanosoma cruzi Heat shock protein 83, putative 0.0141 0.027 0.2471
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0074 0.0081 0.0417
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0236 0.0538 0.0534
Loa Loa (eye worm) hypothetical protein 0.0378 0.094 0.1246
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Echinococcus multilocularis endoplasmin 0.0127 0.0232 0.0278
Leishmania major C-8 sterol isomerase-like protein 0.0378 0.094 1
Leishmania major beta tubulin 0.0089 0.0124 0.0832
Toxoplasma gondii histone deacetylase HDAC4 0.0074 0.0081 0.0047
Echinococcus granulosus histone deacetylase 6 0.0074 0.0081 0.0092
Toxoplasma gondii subtilisin SUB12 0.0157 0.0317 0.0398
Brugia malayi neuropeptide F receptor 0.0236 0.0538 0.0711
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0377 0.0938 0.9969
Toxoplasma gondii beta-1 tubulin, putative 0.0089 0.0124 0.011
Schistosoma mansoni hypothetical protein 0.0176 0.037 0.0366
Trichomonas vaginalis heat shock protein, putative 0.0127 0.0232 0.2996
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Brugia malayi PAN domain containing protein 0.0157 0.0317 0.0416
Echinococcus granulosus voltage dependent calcium channel 0.0145 0.0281 0.0331
Loa Loa (eye worm) histone deacetylase 7A 0.0074 0.0081 0.0102
Leishmania major beta tubulin 0.0089 0.0124 0.0832
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0236 0.0538 0.0534
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.007 0.007 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0236 0.0538 0.0534
Entamoeba histolytica hypothetical protein 0.0119 0.021 0.1319
Echinococcus multilocularis neuropeptides capa receptor 0.0236 0.0538 0.0644
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0236 0.0538 0.0534
Echinococcus granulosus neuropeptide receptor A26 0.075 0.199 0.2376
Schistosoma mansoni protein kinase 0.0138 0.0263 0.0259
Brugia malayi Tubulin beta-1 chain 0.0089 0.0124 0.0159
Schistosoma mansoni hypothetical protein 0.0176 0.037 0.0366
Echinococcus multilocularis ecdysone induced protein 78C 0.007 0.007 0.0084
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0265 0.0622 0.0822
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0263 0.0614 0.0812
Echinococcus multilocularis histone deacetylase 8 0.0074 0.0081 0.0097
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Schistosoma mansoni cercarial elastase (S01 family) 0.0047 0.0004 0.0000088817
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0119 0.0208 0.1774
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0047 0.0004 0.0005
Brugia malayi putative neuropeptide receptor 0.0236 0.0538 0.0711
Loa Loa (eye worm) histone deacetylase 1 0.0074 0.0081 0.0102
Schistosoma mansoni histamine h1 receptor 0.0236 0.0538 0.0534
Schistosoma mansoni neuropeptide F-like receptor 0.0236 0.0538 0.0534
Brugia malayi steroid hormone receptor 0.007 0.007 0.0088
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0061 0.0046 0.0245
Onchocerca volvulus 0.0157 0.0317 0.1836
Schistosoma mansoni histone deacetylase hda2 0.0074 0.0081 0.0077
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0014 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0176 0.037 0.534
Schistosoma mansoni hypothetical protein 0.0236 0.0538 0.0534
Echinococcus multilocularis beta tubulin 0.0089 0.0124 0.0148
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1299 0.3539 0.4232
Schistosoma mansoni hypothetical protein 0.0236 0.0538 0.0534
Echinococcus granulosus epidermal growth factor receptor 0.0146 0.0284 0.0334
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0263 0.0614 0.6339
Schistosoma mansoni thyroid hormone receptor 0.007 0.007 0.0066
Brugia malayi Protein kinase domain containing protein 0.0109 0.018 0.0234
Onchocerca volvulus 0.0157 0.0317 0.1836
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.0375 0.0371
Trypanosoma cruzi heat shock protein 90, putative 0.0114 0.0194 0.1625
Brugia malayi hypothetical protein 0.0236 0.0538 0.0711
Loa Loa (eye worm) pigment dispersing factor receptor c 0.205 0.5656 0.7521
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.007 0.007 0.0079
Echinococcus multilocularis tubulin beta 1 chain 0.0089 0.0124 0.0148
Echinococcus granulosus histone deacetylase 6 0.0074 0.0081 0.0092
Echinococcus multilocularis FTZ F1 alpha 0.007 0.007 0.0084
Trichomonas vaginalis heat shock protein, putative 0.0141 0.027 0.3636
Schistosoma mansoni biogenic amine receptor 0.0236 0.0538 0.0534
Brugia malayi SWIB/MDM2 domain containing protein 0.0176 0.037 0.0486
Echinococcus multilocularis G protein coupled receptor 139 0.0236 0.0538 0.0644
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0074 0.0081 0.0417
Echinococcus granulosus fmrfamide receptor 0.0236 0.0538 0.0639
Loa Loa (eye worm) hypothetical protein 0.0063 0.005 0.006
Echinococcus granulosus hypothetical protein 0.0236 0.0538 0.0639
Echinococcus multilocularis neuropeptide receptor 0.0236 0.0538 0.0644
Onchocerca volvulus 0.0062 0.0046 0.0248
Schistosoma mansoni cercarial elastase (S01 family) 0.0047 0.0004 0.0000088817
Echinococcus multilocularis SWI:SNF matrix associated 0.0176 0.037 0.0442
Schistosoma mansoni cercarial elastase (S01 family) 0.0047 0.0004 0.0000088817
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0236 0.0538 0.0639
Plasmodium vivax heat shock protein 86, putative 0.0141 0.027 0.3398
Echinococcus granulosus epidermal growth factor receptor 0.0078 0.0094 0.0107
Echinococcus multilocularis epidermal growth factor receptor 0.0146 0.0284 0.0339
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Loa Loa (eye worm) hypothetical protein 0.007 0.007 0.0088
Entamoeba histolytica tubulin family protein 0.0089 0.0124 0.0436
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0119 0.0208 0.1774
Echinococcus granulosus tm gpcr rhodopsin 0.1299 0.3539 0.4229
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0364 0.5247
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Leishmania major heat shock protein 83-1 0.0141 0.027 0.2471
Loa Loa (eye worm) hypothetical protein 0.0074 0.0081 0.0102
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0236 0.0538 0.0644
Echinococcus granulosus histone deacetylase 0.0074 0.0081 0.0092
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0119 0.021 0.1319
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0263 0.0614 0.6339
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0236 0.0538 0.3138
Schistosoma mansoni hypothetical protein 0.1367 0.373 0.3727
Echinococcus granulosus g protein coupled receptor 0.0236 0.0538 0.0639
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0138 0.0263 0.0309
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0157 0.0317 0.0398
Echinococcus multilocularis histone deacetylase 6 0.0074 0.0081 0.0097
Brugia malayi putative neuropeptide receptor NPR1 0.0236 0.0538 0.0711
Onchocerca volvulus 0.0236 0.0538 0.3138
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0236 0.0538 0.0711
Leishmania major heat shock protein 83-1 0.0141 0.027 0.2471
Onchocerca volvulus 0.0236 0.0538 0.3138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.007 0.007 0.0088
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Brugia malayi PAN domain containing protein 0.0157 0.0317 0.0416
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Brugia malayi GnHR receptor homolog 0.0236 0.0538 0.0711
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0236 0.0538 0.0711
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0236 0.0538 0.0639
Giardia lamblia Beta tubulin 0.0089 0.0124 0.0436
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0236 0.0538 0.0534
Loa Loa (eye worm) hypothetical protein 0.007 0.007 0.0088
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.032 0.0775 0.0772
Leishmania major heat shock protein 83-1 0.0141 0.027 0.2471
Trichomonas vaginalis AGC family protein kinase 0.0109 0.018 0.21
Onchocerca volvulus 0.0157 0.0317 0.1836
Toxoplasma gondii beta tubulin 0.0089 0.0124 0.011
Echinococcus multilocularis g protein coupled receptor 0.0236 0.0538 0.0644
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0236 0.0538 0.0639
Brugia malayi hypothetical protein 0.0236 0.0538 0.0711
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.3009 0.8364 1
Loa Loa (eye worm) calcium channel 0.0145 0.0281 0.0368
Schistosoma mansoni hypothetical protein 0.032 0.0775 0.0772
Echinococcus granulosus peptide allatostatin:somatostatin 0.0236 0.0538 0.0639
Brugia malayi bZIP transcription factor family protein 0.0095 0.014 0.0181
Echinococcus multilocularis transmembrane protease serine 3 0.0047 0.0004 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0236 0.0538 0.0639
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.0622 0.9642
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Onchocerca volvulus Histone deacetylase 10 homolog 0.0074 0.0081 0.0452
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0109 0.018 0.0215
Onchocerca volvulus 0.0063 0.005 0.0267
Onchocerca volvulus 0.0063 0.005 0.0267
Schistosoma mansoni histone deacetylase 4 5 0.0074 0.0081 0.0077
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0236 0.0538 0.0711
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0236 0.0538 0.0534
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.007 0.0079
Brugia malayi PAN domain containing protein 0.0157 0.0317 0.0416
Schistosoma mansoni Tr4/Tr2 (homologue) 0.007 0.007 0.0066
Toxoplasma gondii histone deacetylase HDAC5 0.0074 0.0081 0.0047
Leishmania major heat shock protein 83-1 0.0141 0.027 0.2471
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.0538 0.0711
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0236 0.0538 0.0534
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0063 0.005 0.0059
Brugia malayi hypothetical protein 0.0074 0.0083 0.0105
Brugia malayi PAN domain containing protein 0.0157 0.0317 0.0416
Echinococcus multilocularis heat shock protein 90 0.0141 0.027 0.0322
Brugia malayi Nuclear hormone receptor family member nhr-1 0.007 0.007 0.0088
Echinococcus multilocularis Tubulin beta 2C chain 0.0089 0.0124 0.0148
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Brugia malayi follicle stimulating hormone receptor 0.0236 0.0538 0.0711
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.007 0.0088
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0119 0.0208 0.1774
Echinococcus granulosus Tubulin beta 2C chain 0.0089 0.0124 0.0143
Brugia malayi Serotonin receptor 0.0236 0.0538 0.0711
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0063 0.005 0.006
Loa Loa (eye worm) PAN domain-containing protein 0.0157 0.0317 0.0416
Leishmania major histone deacetylase, putative 0.0074 0.0081 0.0354
Schistosoma mansoni tubulin subunit beta 0.0089 0.0124 0.012
Echinococcus granulosus FTZ F1 alpha 0.007 0.007 0.0079
Leishmania major beta tubulin 0.0089 0.0124 0.0832
Entamoeba histolytica tubulin family protein 0.0089 0.0124 0.0436
Brugia malayi replication factor A 73 kDa subunit 0.0069 0.0066 0.0083
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0145 0.0281 0.2596
Brugia malayi Histone deacetylase family protein 0.0074 0.0081 0.0102
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0176 0.037 0.5396
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0127 0.0232 0.2051
Echinococcus multilocularis tubulin subunit beta 0.0089 0.0124 0.0148
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0263 0.0614 0.061
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0047 0.0004 0.0005
Chlamydia trachomatis SWIB complex protein 0.0176 0.037 0.5134
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Echinococcus multilocularis sodium channel protein 0.0377 0.0938 0.1121
Toxoplasma gondii PAN domain-containing protein 0.2444 0.6769 1
Schistosoma mansoni tubulin subunit beta 0.0089 0.0124 0.012
Echinococcus granulosus somatostatin receptor 0.0236 0.0538 0.0639
Echinococcus granulosus dro:myosuppressin receptor 0.0236 0.0538 0.0639
Trypanosoma brucei histone deacetylase 2 0.0074 0.0081 0.0354
Echinococcus multilocularis beta tubulin 0.0089 0.0124 0.0148
Onchocerca volvulus 0.0157 0.0317 0.1836
Echinococcus granulosus Tubulin beta 2C chain 0.0089 0.0124 0.0143
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0119 0.0208 0.1774
Toxoplasma gondii histone deacetylase HDAC2 0.0074 0.0081 0.0047
Loa Loa (eye worm) hypothetical protein 0.0157 0.0317 0.0416
Loa Loa (eye worm) histone deacetylase 3 0.0074 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.0157 0.0317 0.0416
Trichomonas vaginalis tubulin epsilon chain, putative 0.0089 0.0124 0.1144
Trypanosoma cruzi heat shock protein 90, putative 0.0141 0.027 0.2471
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.007 0.007 0.0066
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0145 0.0281 0.0277
Leishmania major beta tubulin 0.0089 0.0124 0.0832
Schistosoma mansoni amine GPCR 0.0236 0.0538 0.0534
Loa Loa (eye worm) hypothetical protein 0.0157 0.0317 0.0416
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.007 0.007 0.0088
Trichomonas vaginalis histone deacetylase, putative 0.0074 0.0081 0.0417
Echinococcus multilocularis SWI:SNF matrix associated 0.0176 0.037 0.0442
Toxoplasma gondii PAN/Apple domain-containing protein 0.0157 0.0317 0.0398
Schistosoma mansoni replication factor A 1 rfa1 0.0069 0.0066 0.0062
Schistosoma mansoni tyrosine kinase 0.0078 0.0094 0.0089
Brugia malayi PAN domain containing protein 0.0157 0.0317 0.0416
Echinococcus multilocularis neuropeptide FF receptor 2 0.0676 0.1782 0.213
Trichomonas vaginalis AGC family protein kinase 0.0109 0.018 0.21
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0127 0.0232 1
Schistosoma mansoni apoptosis regulator bax 0.032 0.0775 0.0772
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0364 0.5247
Onchocerca volvulus 0.0236 0.0538 0.3138
Brugia malayi YY1-associated factor 2 0.0063 0.005 0.006
Echinococcus multilocularis neuropeptide receptor 0.0236 0.0538 0.0644
Schistosoma mansoni thyroid hormone receptor 0.007 0.007 0.0066
Loa Loa (eye worm) hypothetical protein 0.007 0.007 0.0088
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0236 0.0538 0.0534
Schistosoma mansoni tubulin subunit beta 0.0089 0.0124 0.012
Echinococcus multilocularis fmrfamide receptor 0.0236 0.0538 0.0644
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Trypanosoma brucei beta tubulin 0.0089 0.0124 0.0832
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.007 0.007 0.0386
Echinococcus multilocularis rhodopsin orphan GPCR 0.0236 0.0538 0.0644
Echinococcus multilocularis glycoprotein Antigen 5 0.0047 0.0004 0.0005
Trypanosoma brucei heat shock protein 90, putative 0.0141 0.027 0.2471
Brugia malayi histone deacetylase 1 (HD1) 0.0074 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.0106 0.0173 0.0225
Echinococcus multilocularis neuropeptide Y receptor 0.0236 0.0538 0.0644
Echinococcus granulosus tm gpcr rhodopsin 0.0236 0.0538 0.0639
Echinococcus granulosus adenylate cyclase type IX 0.0086 0.0117 0.0135
Leishmania major heat shock protein 83-1 0.0141 0.027 0.2471
Loa Loa (eye worm) hypothetical protein 0.0063 0.005 0.006
Schistosoma mansoni tyrosine kinase 0.0078 0.0094 0.0089
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0127 0.0232 0.0273
Onchocerca volvulus 0.0157 0.0317 0.1836
Trypanosoma brucei beta tubulin 0.0089 0.0124 0.0832
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0263 0.0614 0.073
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.007 0.007 0.0066
Echinococcus multilocularis Tubulin beta 2C chain 0.0089 0.0124 0.0148
Brugia malayi phosphoinositide-dependent protein kinase I 0.0109 0.018 0.0234
Onchocerca volvulus Bile acid receptor homolog 0.007 0.007 0.0386
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.007 0.0084
Schistosoma mansoni hypothetical protein 0.0047 0.0004 0.0000088817
Loa Loa (eye worm) BEN-1 protein 0.0089 0.0124 0.0159
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0176 0.037 0.0442
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0236 0.0538 0.0711
Trypanosoma cruzi histone deacetylase, putative 0.0074 0.0081 0.0354
Echinococcus granulosus nmda type glutamate receptor 0.0118 0.0204 0.024
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0378 0.094 0.1246
Plasmodium vivax histone deacetylase 1, putative 0.0074 0.0081 0.0058
Onchocerca volvulus 0.0063 0.005 0.0267
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.0622 0.9642
Echinococcus multilocularis rhodopsin orphan GPCR 0.0236 0.0538 0.0644
Schistosoma mansoni protein kinase 0.0138 0.0263 0.0259
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Schistosoma mansoni TRABID protein (C64 family) 0.0063 0.005 0.0045
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Echinococcus granulosus tachykinin peptides receptor 99D 0.0529 0.1364 0.1627
Toxoplasma gondii PAN domain-containing protein 0.0157 0.0317 0.0398
Onchocerca volvulus 0.0074 0.0083 0.0461
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0069 0.0066 0.0079
Echinococcus granulosus g protein coupled receptor 0.0236 0.0538 0.0639
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0263 0.0614 0.6339
Trichomonas vaginalis tubulin beta chain, putative 0.0089 0.0124 0.1144
Loa Loa (eye worm) G-protein coupled receptor 0.0236 0.0538 0.0711
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0047 0.0004 0.0000088817
Echinococcus multilocularis histone deacetylase 3 0.0074 0.0081 0.0097
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Schistosoma mansoni hypothetical protein 0.0047 0.0004 0.0000088817
Echinococcus granulosus beta tubulin 0.0089 0.0124 0.0143
Trypanosoma cruzi heat shock protein 85, putative 0.0141 0.027 0.2471
Brugia malayi hypothetical protein 0.0236 0.0538 0.0711
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0236 0.0538 0.0534
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0145 0.0281 0.0331
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0236 0.0538 0.0644
Loa Loa (eye worm) G-protein coupled receptor 0.0236 0.0538 0.0711
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Plasmodium vivax histone deacetylase, putative 0.0074 0.0081 0.0058
Schistosoma mansoni peptide (allatostatin)-like receptor 0.065 0.1706 0.1703
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.007 0.0088
Schistosoma mansoni hypothetical protein 0.0683 0.1799 0.1796
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0062 0.0046 0.0248
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0119 0.0208 0.1774
Loa Loa (eye worm) hypothetical protein 0.0168 0.0347 0.0456
Trypanosoma brucei heat shock protein, putative 0.0141 0.027 0.2471
Loa Loa (eye worm) heat shock protein 90 0.0141 0.027 0.0353
Loa Loa (eye worm) voltage-dependent calcium channel 0.0145 0.0281 0.0368
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0069 0.0066 0.0083
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Brugia malayi PAN domain containing protein 0.0157 0.0317 0.0416
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0263 0.0614 0.0734
Giardia lamblia Beta tubulin 0.0089 0.0124 0.0436
Brugia malayi brahma associated protein 60 kDa 0.0176 0.037 0.0486
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0069 0.0066 0.0163
Leishmania major beta tubulin 0.0089 0.0124 0.0832
Brugia malayi Nuclear hormone receptor family member nhr-14 0.007 0.007 0.0088
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0145 0.0281 0.0336
Echinococcus granulosus rhodopsin orphan GPCR 0.0236 0.0538 0.0639
Trichomonas vaginalis tubulin epsilon chain, putative 0.0089 0.0124 0.1144
Echinococcus granulosus rhodopsin orphan GPCR 0.0236 0.0538 0.0639
Loa Loa (eye worm) hypothetical protein 0.0074 0.0081 0.0102
Echinococcus multilocularis histone deacetylase 7 0.0074 0.0081 0.0097
Schistosoma mansoni cercarial elastase (S01 family) 0.0047 0.0004 0.0000088817
Plasmodium falciparum histone deacetylase 2 0.0074 0.0081 0.0532
Schistosoma mansoni adenoreceptor 0.0236 0.0538 0.0534
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0176 0.037 0.0476
Trypanosoma brucei hypothetical protein 0.0119 0.0208 0.1774
Echinococcus granulosus heat shock protein 90 0.0127 0.0232 0.0273
Loa Loa (eye worm) brahma associated protein 0.0176 0.037 0.0486
Schistosoma mansoni brg-1 associated factor 0.0176 0.037 0.0366
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0057 0.0033 0.0029
Echinococcus granulosus Zinc finger RanBP2 type 0.0063 0.005 0.0054
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0145 0.0281 0.0331
Schistosoma mansoni biogenic amine receptor 0.0236 0.0538 0.0534
Echinococcus multilocularis g protein coupled receptor 0.0236 0.0538 0.0644
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.007 0.007 0.0088
Echinococcus multilocularis histone deacetylase 6 0.0074 0.0081 0.0097
Schistosoma mansoni neuropeptide receptor 0.0236 0.0538 0.0534
Trichomonas vaginalis tubulin gamma chain, putative 0.0089 0.0124 0.1144
Plasmodium falciparum histone deacetylase 1 0.0074 0.0081 0.0532
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0014 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0364 0.5247
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0085 0.0111 0.0694
Brugia malayi hypothetical protein 0.1512 0.4139 0.5501
Schistosoma mansoni hypothetical protein 0.0683 0.1799 0.1796
Echinococcus granulosus tissue type plasminogen activator 0.0073 0.0078 0.0088
Giardia lamblia Heat shock protein HSP 90-alpha 0.0127 0.0232 0.1548
Leishmania major heat shock protein 83-1 0.0141 0.027 0.2471
Echinococcus granulosus biogenic amine 5HT receptor 0.0236 0.0538 0.0639
Onchocerca volvulus 0.0236 0.0538 0.3138
Trichomonas vaginalis heat shock protein, putative 0.0127 0.0232 0.2996
Brugia malayi map kinase activated protein kinase protein 2 0.0178 0.0375 0.0493
Trypanosoma brucei calpain, putative 0.0119 0.0208 0.1774
Brugia malayi neuropeptide F receptor 0.0236 0.0538 0.0711
Loa Loa (eye worm) tubulin beta-2A chain 0.0089 0.0124 0.0159
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0236 0.0538 0.0534
Brugia malayi larval opioid receptor 0.0236 0.0538 0.0711
Leishmania major beta tubulin 0.0089 0.0124 0.0832
Echinococcus multilocularis neuropeptide Y receptor 0.0236 0.0538 0.0644
Plasmodium falciparum heat shock protein 90 0.0141 0.027 0.3713
Echinococcus multilocularis insulin receptor 0.0047 0.0004 0.0005
Plasmodium vivax tubulin beta chain, putative 0.0089 0.0124 0.0812
Echinococcus granulosus voltage dependent calcium channel 0.0145 0.0281 0.0331
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0063 0.005 0.0059
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0391 0.5699
Loa Loa (eye worm) hypothetical protein 0.007 0.007 0.0088
Schistosoma mansoni cercarial elastase (S01 family) 0.0047 0.0004 0.0000088817
Echinococcus multilocularis glutamate receptor 2 0.005 0.0014 0.0016
Brugia malayi Nuclear hormone receptor-like 1 0.007 0.007 0.0088
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Schistosoma mansoni hypothetical protein 0.0176 0.037 0.0366
Echinococcus multilocularis Tubulin beta 2C chain 0.0089 0.0124 0.0148
Onchocerca volvulus 0.0157 0.0317 0.1836
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0273 0.0643 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0089 0.0124 0.0143
Schistosoma mansoni retinoic acid receptor RXR 0.007 0.007 0.0066
Schistosoma mansoni endoplasmin 0.0141 0.027 0.0266
Leishmania major beta tubulin 0.0089 0.0124 0.0832
Echinococcus multilocularis thyroid hormone receptor alpha 0.007 0.007 0.0084
Echinococcus granulosus rhodopsin orphan GPCR 0.0236 0.0538 0.0639
Schistosoma mansoni cercarial elastase (S01 family) 0.0047 0.0004 0.0000088817
Trichomonas vaginalis histone deacetylase, putative 0.0074 0.0081 0.0417
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0109 0.018 0.0234
Trypanosoma brucei histone deacetylase 1 0.0074 0.0081 0.0354
Onchocerca volvulus 0.007 0.0071 0.0394
Brugia malayi G protein-coupled receptor 0.0236 0.0538 0.0711
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0109 0.018 0.021
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.032 0.0775 0.0927
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0265 0.0622 0.0822
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.007 0.0088
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0529 0.1364 0.1631
Echinococcus granulosus allatostatin A receptor 0.065 0.1706 0.2036
Onchocerca volvulus 0.0236 0.0538 0.3138
Echinococcus granulosus biogenic amine 5HT receptor 0.0236 0.0538 0.0639
Echinococcus granulosus histone deacetylase 7 0.0074 0.0081 0.0092
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0069 0.0066 0.0074
Toxoplasma gondii microneme protein MIC4 0.0157 0.0317 0.0398
Loa Loa (eye worm) hypothetical protein 0.0157 0.0317 0.0416
Loa Loa (eye worm) hypothetical protein 0.0145 0.0281 0.0368
Loa Loa (eye worm) latrophilin receptor protein 2 0.0683 0.1799 0.2389
Schistosoma mansoni histone deacetylase hda2 0.0074 0.0081 0.0077
Trypanosoma cruzi histone deacetylase, putative 0.0074 0.0081 0.0354
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0236 0.0538 0.0534
Loa Loa (eye worm) hypothetical protein 0.0092 0.0133 0.0171
Echinococcus granulosus g protein coupled receptor 0.0236 0.0538 0.0639
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.012 0.0212 0.0276
Loa Loa (eye worm) hypothetical protein 0.271 0.752 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0014 0.0011
Schistosoma mansoni tyrosine kinase 0.0146 0.0284 0.028
Brugia malayi RE15519p 0.0236 0.0538 0.0711
Echinococcus multilocularis Mastin 0.0047 0.0004 0.0005
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.032 0.0775 0.0923
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0127 0.0232 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0236 0.0538 0.0534
Schistosoma mansoni nuclear hormone receptor 0.007 0.007 0.0066
Brugia malayi brahma associated protein 60 kDa 0.0176 0.037 0.0486
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0047 0.0004 0.0000088817
Trypanosoma brucei heat shock protein, putative 0.0141 0.027 0.2471
Brugia malayi Protein kinase domain containing protein 0.0073 0.008 0.0101
Trypanosoma brucei heat shock protein, putative 0.0141 0.027 0.2471
Brugia malayi beta-tubulin, identical 0.0089 0.0124 0.0159
Loa Loa (eye worm) hypothetical protein 0.007 0.007 0.0088
Echinococcus multilocularis adenylate cyclase type IX 0.0086 0.0117 0.014
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0014 0.0016
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0063 0.005 0.006
Loa Loa (eye worm) beta-tubulin 0.0089 0.0124 0.0159
Schistosoma mansoni cercarial elastase (S01 family) 0.0047 0.0004 0.0000088817
Toxoplasma gondii microneme protein MIC17B 0.0157 0.0317 0.0398
Toxoplasma gondii heat shock protein HSP90 0.0141 0.027 0.0328
Echinococcus multilocularis neuropeptide s receptor 0.075 0.199 0.238
Loa Loa (eye worm) neuropeptide F receptor 0.0236 0.0538 0.0711
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0236 0.0538 0.0534
Schistosoma mansoni RAR-like nuclear receptor 0.007 0.007 0.0066
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0236 0.0538 0.0644
Schistosoma mansoni voltage-gated cation channel 0.0145 0.0281 0.0277
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Echinococcus multilocularis adenylate cyclase 9 0.0062 0.0046 0.0056
Trypanosoma cruzi histone deacetylase 1, putative 0.0074 0.0081 0.0354
Toxoplasma gondii PAN domain-containing protein 0.2444 0.6769 1
Echinococcus multilocularis g-protein coupled receptor 0.0236 0.0538 0.0644
Onchocerca volvulus 0.0157 0.0317 0.1836
Toxoplasma gondii PAN domain-containing protein 0.0157 0.0317 0.0398
Schistosoma mansoni tubulin subunit beta 0.0089 0.0124 0.012
Schistosoma mansoni hypothetical protein 0.0063 0.005 0.0045
Schistosoma mansoni heat shock protein 0.0141 0.027 0.0266
Schistosoma mansoni amine GPCR 0.0236 0.0538 0.0534
Echinococcus granulosus beta tubulin 0.0089 0.0124 0.0143
Loa Loa (eye worm) TYRA-2 protein 0.0236 0.0538 0.0711
Loa Loa (eye worm) PAN domain-containing protein 0.0157 0.0317 0.0416
Schistosoma mansoni cercarial elastase (S01 family) 0.0047 0.0004 0.0000088817
Loa Loa (eye worm) tubulin beta chain 0.0089 0.0124 0.0159
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0145 0.0281 0.0277
Loa Loa (eye worm) tubulin beta-4 chain 0.0089 0.0124 0.0159
Onchocerca volvulus 0.0236 0.0538 0.3138
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0236 0.0538 0.0644
Trypanosoma brucei calpain-like protein, putative 0.0119 0.0208 0.1774
Echinococcus granulosus rhodopsin orphan GPCR 0.0236 0.0538 0.0639
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Brugia malayi Serotonin receptor 0.0236 0.0538 0.0711
Schistosoma mansoni histone deacetylase 0.0074 0.0081 0.0077
Giardia lamblia Heat shock protein HSP 90-alpha 0.0141 0.027 0.1932
Leishmania major beta tubulin 0.0089 0.0124 0.0832
Leishmania major hypothetical protein, conserved 0.0073 0.0078 0.0318
Echinococcus granulosus tm gpcr rhodopsin 0.0236 0.0538 0.0639
Plasmodium falciparum cysteine repeat modular protein 1 0.0073 0.0078 0.0477
Brugia malayi hypothetical protein 0.0236 0.0538 0.0711
Brugia malayi Steroid receptor seven-up type 2 0.007 0.007 0.0088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0236 0.0538 0.0644
Echinococcus multilocularis Tubulin beta 2C chain 0.0089 0.0124 0.0148
Trypanosoma cruzi heat shock protein 90, putative 0.0127 0.0232 0.2051
Echinococcus multilocularis g protein coupled receptor 0.0236 0.0538 0.0644
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0063 0.005 0.0267
Loa Loa (eye worm) hypothetical protein 0.0157 0.0317 0.0416
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0047 0.0004 0.0000088817
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0364 0.5247
Onchocerca volvulus 0.0236 0.0538 0.3138
Leishmania major beta tubulin 0.0089 0.0124 0.0832
Trypanosoma cruzi histone deacetylase 1, putative 0.0074 0.0081 0.0354
Schistosoma mansoni neuropeptide receptor 0.0236 0.0538 0.0534
Trichomonas vaginalis tubulin alpha chain, putative 0.0089 0.0124 0.1144
Schistosoma mansoni serine-type protease inhibitor 0.3589 1 1
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Onchocerca volvulus 0.0236 0.0538 0.3138
Schistosoma mansoni tyrosine kinase 0.0077 0.0091 0.0087
Echinococcus granulosus endoplasmin 0.0127 0.0232 0.0273
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0236 0.0538 0.0644
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0145 0.0281 0.0331
Schistosoma mansoni jun-related protein 0.0077 0.009 0.0086
Echinococcus granulosus neuropeptide FF receptor 2 0.0676 0.1782 0.2126
Leishmania major beta tubulin 0.0089 0.0124 0.0832
Trypanosoma cruzi heat shock protein 85, putative 0.0127 0.0232 0.2051
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.1343 0.3663 0.4379
Onchocerca volvulus 0.0157 0.0317 0.1836
Plasmodium vivax hypothetical protein, conserved 0.0176 0.037 0.5166
Leishmania major heat shock protein 83-1 0.0141 0.027 0.2471
Loa Loa (eye worm) BEN-1 protein 0.0089 0.0124 0.0159
Loa Loa (eye worm) hypothetical protein 0.007 0.007 0.0088
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0236 0.0538 0.0534
Brugia malayi Nuclear hormone receptor family member nhr-40 0.007 0.007 0.0088
Brugia malayi nuclear receptor NHR-88 0.007 0.007 0.0088
Onchocerca volvulus Neuropeptide F receptor homolog 0.0236 0.0538 0.3138
Echinococcus multilocularis voltage dependent calcium channel 0.0145 0.0281 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-31 0.007 0.007 0.0088
Treponema pallidum heat shock protein 90 0.0127 0.0232 0.2403
Echinococcus multilocularis somatostatin receptor 0.0236 0.0538 0.0644
Echinococcus granulosus zinc finger protein Ran binding 0.0063 0.005 0.0054
Loa Loa (eye worm) hypothetical protein 0.0193 0.0419 0.0551
Echinococcus granulosus alpha 1A adrenergic receptor 0.0236 0.0538 0.0639
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.007 0.0088
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0236 0.0538 0.0639
Echinococcus granulosus neuropeptide s receptor 0.075 0.199 0.2376
Echinococcus granulosus jun protein 0.0095 0.014 0.0163
Echinococcus multilocularis nmda type glutamate receptor 0.0118 0.0204 0.0244
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0119 0.0208 0.1774
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0236 0.0538 0.0534
Toxoplasma gondii hypothetical protein 0.0157 0.0317 0.0398
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0683 0.1799 0.2148
Leishmania major beta tubulin 0.0089 0.0124 0.0832
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0138 0.0263 0.0314
Schistosoma mansoni fusion 0.0063 0.005 0.0045
Echinococcus granulosus glutamate receptor 2 0.005 0.0014 0.0011
Echinococcus granulosus Tubulin beta 2C chain 0.0089 0.0124 0.0143
Echinococcus granulosus ring and YY1 binding protein 0.0063 0.005 0.0054
Toxoplasma gondii histone deacetylase HDAC1 0.0074 0.0081 0.0047
Echinococcus granulosus neuropeptide Y receptor 0.0236 0.0538 0.0639
Echinococcus multilocularis neuropeptides capa receptor 0.0236 0.0538 0.0644
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0236 0.0538 0.0711
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0118 0.0204 0.0244
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0078 0.0318
Trypanosoma brucei histone deacetylase, putative 0.0074 0.0081 0.0354
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0176 0.037 0.5166
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Chlamydia trachomatis DNA topoisomerase I 0.0176 0.037 0.5134
Loa Loa (eye worm) hypothetical protein 0.0157 0.0317 0.0416
Leishmania major heat shock protein 83-1 0.0141 0.027 0.2471
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0145 0.0281 0.0368
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0047 0.0004 0.0000088817
Onchocerca volvulus 0.0236 0.0538 0.3138
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0145 0.0281 0.2596
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0145 0.0281 0.0336
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0236 0.0538 0.0644
Loa Loa (eye worm) hypothetical protein 0.1367 0.373 0.4957
Toxoplasma gondii heat shock protein 90, putative 0.0141 0.027 0.0328
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0069 0.0066 0.0163
Onchocerca volvulus Protein ultraspiracle homolog 0.007 0.007 0.0386
Brugia malayi Endoplasmin precursor 0.0141 0.027 0.0353
Entamoeba histolytica heat shock protein 90, putative 0.0141 0.027 0.1932
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0273 0.0643 1
Trichomonas vaginalis heat shock protein, putative 0.0127 0.0232 0.2996
Toxoplasma gondii beta-tubulin, putative 0.0089 0.0124 0.011
Echinococcus multilocularis SWI:SNF matrix associated 0.0176 0.037 0.0442
Schistosoma mansoni neuropeptide F-like receptor 0.0236 0.0538 0.0534
Toxoplasma gondii kringle domain-containing protein 0.0073 0.0078 0.0042
Loa Loa (eye worm) hypothetical protein 0.0063 0.005 0.006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.007 0.0084
Echinococcus multilocularis G-protein coupled receptor, putative 0.0236 0.0538 0.0644
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0047 0.0004 0.0000088817
Brugia malayi AKH receptor 0.0236 0.0538 0.0711
Echinococcus granulosus adenylate cyclase 9 0.0062 0.0046 0.0051
Trypanosoma cruzi heat shock protein 85, putative 0.0141 0.027 0.2471
Brugia malayi PAN domain containing protein 0.0157 0.0317 0.0416
Giardia lamblia DNA repair protein RAD52 0.042 0.1057 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0119 0.0208 0.1774
Brugia malayi Tachykinin-like peptides receptor 99D 0.0676 0.1782 0.2365
Schistosoma mansoni tyrosine kinase 0.0077 0.0091 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0119 0.0208 0.1774
Schistosoma mansoni steroid hormone receptor ad4bp 0.007 0.007 0.0066
Brugia malayi hypothetical protein 0.0236 0.0538 0.0711
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.007 0.0088
Brugia malayi histone deacetylase 11 0.0074 0.0081 0.0102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0236 0.0538 0.0534
Toxoplasma gondii histone deacetylase HDAC3 0.0074 0.0081 0.0047
Trypanosoma brucei C-8 sterol isomerase, putative 0.0378 0.094 1
Trypanosoma brucei heat shock protein, putative 0.0141 0.027 0.2471
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.007 0.007 0.0084
Schistosoma mansoni hypothetical protein 0.0236 0.0538 0.0534
Loa Loa (eye worm) hypothetical protein 0.0063 0.005 0.006
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0014 0.0011
Schistosoma mansoni neuropeptide receptor 0.0236 0.0538 0.0534
Brugia malayi sulfakinin receptor protein 0.1512 0.4139 0.5501
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.005 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.032 0.0775 0.1026
Schistosoma mansoni tubulin subunit beta 0.0089 0.0124 0.012
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0172 0.0357 0.0458
Trypanosoma brucei RNA helicase, putative 0.021 0.0465 0.4664
Trypanosoma cruzi histone deacetylase, putative 0.0074 0.0081 0.0354
Loa Loa (eye worm) PAN domain-containing protein 0.0157 0.0317 0.0416
Echinococcus granulosus heat shock protein 90 0.0141 0.027 0.0318
Leishmania major beta tubulin 0.0089 0.0124 0.0832
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0378 0.094 1
Echinococcus multilocularis serotonin receptor 0.0236 0.0538 0.0644
Brugia malayi Nuclear hormone receptor family member nhr-41 0.007 0.007 0.0088
Loa Loa (eye worm) adenylyl cyclase 3 0.0145 0.0283 0.0371
Schistosoma mansoni RNA binding protein 0.0063 0.005 0.0045
Trypanosoma cruzi histone deacetylase, putative 0.0074 0.0081 0.0354
Schistosoma mansoni hypothetical protein 0.0236 0.0538 0.0534
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0085 0.0111 0.1757
Loa Loa (eye worm) hypothetical protein 0.0073 0.0078 0.0098
Trypanosoma brucei Heat shock protein 83, putative 0.0141 0.027 0.2471
Echinococcus multilocularis histone deacetylase 0.0074 0.0081 0.0097
Onchocerca volvulus 0.0236 0.0538 0.3138
Toxoplasma gondii microneme protein MIC17C 0.0157 0.0317 0.0398
Leishmania major heat shock protein 83-1 0.0141 0.027 0.2471
Echinococcus granulosus histone deacetylase 3 0.0074 0.0081 0.0092
Echinococcus granulosus tubulin beta 1 chain 0.0089 0.0124 0.0143
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Echinococcus multilocularis rhodopsin orphan GPCR 0.0236 0.0538 0.0644
Loa Loa (eye worm) steroid hormone receptor 0.007 0.007 0.0088
Brugia malayi Calcitonin receptor-like protein seb-1 0.205 0.5656 0.7521
Brugia malayi heat shock protein 90 0.0141 0.027 0.0353
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0176 0.037 0.0476
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0391 0.5699
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0119 0.0208 0.1774
Loa Loa (eye worm) hypothetical protein 0.0157 0.0317 0.0416
Echinococcus multilocularis enteropeptidase 0.0047 0.0004 0.0005
Toxoplasma gondii microneme protein, putative 0.0157 0.0317 0.0398
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0236 0.0538 0.0711
Onchocerca volvulus 0.0176 0.037 0.2147
Echinococcus granulosus Tubulin beta 2C chain 0.0089 0.0124 0.0143
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0236 0.0538 0.0534
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0089 0.0124 0.0148
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Loa Loa (eye worm) TK/ROR protein kinase 0.0073 0.008 0.0101
Loa Loa (eye worm) tubulin beta-1 chain 0.0089 0.0124 0.0159
Leishmania major heat shock protein 83-1 0.0141 0.027 0.2471
Loa Loa (eye worm) melatonin receptor type 1A 0.0236 0.0538 0.0711
Brugia malayi Dopamine receptor protein 1 0.0236 0.0538 0.0711
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0119 0.0208 0.1774
Schistosoma mansoni cercarial elastase (S01 family) 0.0047 0.0004 0.0000088817
Toxoplasma gondii transporter, cation channel family protein 0.0145 0.0281 0.0344
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0074 0.0081 0.0417
Schistosoma mansoni hypothetical protein 0.0073 0.0078 0.0074
Schistosoma mansoni histone deacetylase 1 2 3 0.0074 0.0081 0.0077
Echinococcus multilocularis epidermal growth factor receptor 0.0078 0.0094 0.0112
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0273 0.0643 1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.005 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Schistosoma mansoni hypothetical protein 0.0683 0.1799 0.1796
Loa Loa (eye worm) hypothetical protein 0.065 0.1706 0.2264
Brugia malayi ecdysteroid receptor 0.007 0.007 0.0088
Schistosoma mansoni amine GPCR 0.0236 0.0538 0.0534
Echinococcus multilocularis neuropeptide receptor A26 0.075 0.199 0.238
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0236 0.0538 0.0534
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0364 0.5247
Schistosoma mansoni cercarial elastase (S01 family) 0.0047 0.0004 0.0000088817
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0063 0.005 0.0054
Echinococcus multilocularis heat shock protein 90 0.0127 0.0232 0.0278
Schistosoma mansoni opsin-like receptor 0.0236 0.0538 0.0534
Brugia malayi PAN domain containing protein 0.0157 0.0317 0.0416
Trypanosoma brucei heat shock protein 90, putative 0.0141 0.027 0.2471
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Leishmania major beta tubulin 0.0089 0.0124 0.0832
Echinococcus granulosus neuropeptides capa receptor 0.0236 0.0538 0.0639
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0176 0.037 0.5396
Echinococcus multilocularis histone deacetylase 1 0.0074 0.0081 0.0097
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.1343 0.3663 0.4377
Trypanosoma brucei heat shock protein, putative 0.0141 0.027 0.2471
Brugia malayi Nuclear hormone receptor family member nhr-49 0.007 0.007 0.0088
Leishmania major histone deacetylase, putative 0.0074 0.0081 0.0354
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0236 0.0538 0.0639
Trypanosoma brucei heat shock protein, putative 0.0141 0.027 0.2471
Echinococcus multilocularis rhodopsin orphan GPCR 0.0236 0.0538 0.0644
Leishmania major beta tubulin 0.0089 0.0124 0.0832
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0236 0.0538 0.0711
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Echinococcus granulosus histone deacetylase 8 0.0074 0.0081 0.0092
Toxoplasma gondii PAN domain-containing protein 0.0157 0.0317 0.0398
Brugia malayi Dopamine receptor 0.0236 0.0538 0.0711
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0078 0.0094 0.0107
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0236 0.0538 0.0711
Echinococcus granulosus histone deacetylase 6 0.0074 0.0081 0.0092
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0273 0.0643 1
Brugia malayi ORL1-like opioid receptor 0.0236 0.0538 0.0711
Onchocerca volvulus 0.0236 0.0538 0.3138
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0364 0.5247
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.007 0.007 0.0084
Brugia malayi G-protein coupled receptor 0.0236 0.0538 0.0711
Leishmania major heat shock protein 83-1 0.0141 0.027 0.2471
Echinococcus granulosus g-protein coupled receptor 0.0236 0.0538 0.0639
Echinococcus multilocularis Tubulin beta 2C chain 0.0089 0.0124 0.0148
Echinococcus granulosus glutamate NMDA receptor subunit 0.0278 0.0658 0.0782
Schistosoma mansoni biogenic amine receptor 0.0236 0.0538 0.0534
Echinococcus multilocularis sex peptide receptor 0.0236 0.0538 0.0644
Trypanosoma cruzi heat shock protein 85, putative 0.0141 0.027 0.2471
Schistosoma mansoni biogenic amine (5HT) receptor 0.0236 0.0538 0.0534
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.018 0.0176
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0273 0.0643 0.5751
Schistosoma mansoni retinoid-x-receptor (RXR) 0.007 0.007 0.0066
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.271 0.752 1
Onchocerca volvulus Glucosylceramidase homolog 0.0174 0.0364 0.2115
Loa Loa (eye worm) hypothetical protein 0.0106 0.0173 0.0225
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.0622 0.9642
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.007 0.0079
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.007 0.007 0.0079
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0377 0.0938 0.1117
Loa Loa (eye worm) hypothetical protein 0.0063 0.005 0.006
Echinococcus granulosus neuropeptide Y receptor 0.0236 0.0538 0.0639
Echinococcus multilocularis dro:myosuppressin receptor 0.0236 0.0538 0.0644
Echinococcus multilocularis zinc finger protein Ran binding 0.0063 0.005 0.0059
Onchocerca volvulus 0.0236 0.0538 0.3138
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.007 0.007 0.0084
Toxoplasma gondii microneme protein MIC17A 0.0157 0.0317 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.007 0.0088
Echinococcus granulosus 7TM GPCR rhodopsin 0.0236 0.0538 0.0639
Loa Loa (eye worm) hypothetical protein 0.0062 0.0046 0.0056
Trypanosoma brucei histone deacetylase 3 0.0074 0.0081 0.0354
Schistosoma mansoni neuropeptide f receptor 76f 0.0236 0.0538 0.0534
Schistosoma mansoni biogenic amine (5HT) receptor 0.0236 0.0538 0.0534
Brugia malayi hypothetical protein 0.0236 0.0538 0.0711
Brugia malayi Histone deacetylase 1 0.0074 0.0081 0.0102
Brugia malayi Dopamine receptor protein 2 0.0236 0.0538 0.0711
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0236 0.0538 0.0644
Schistosoma mansoni endoplasmin 0.0141 0.027 0.0266
Leishmania major heat shock protein 83-1 0.0141 0.027 0.2471
Trichomonas vaginalis tubulin, putative 0.0089 0.0124 0.1144
Schistosoma mansoni glutamate receptor NMDA 0.0278 0.0658 0.0654
Loa Loa (eye worm) PAN domain-containing protein 0.0157 0.0317 0.0416
Brugia malayi hypothetical protein 0.0236 0.0538 0.0711
Giardia lamblia Grp94/Hsp90 0.0127 0.0232 0.1548
Schistosoma mansoni hypothetical protein 0.032 0.0775 0.0772
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0126 0.023 0.0275
Trypanosoma cruzi histone deacetylase, putative 0.0074 0.0081 0.0354
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Onchocerca volvulus 0.0157 0.0317 0.1836
Schistosoma mansoni cercarial elastase (S01 family) 0.0047 0.0004 0.0000088817
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0236 0.0538 0.0534
Echinococcus granulosus rhodopsin orphan GPCR 0.0236 0.0538 0.0639
Onchocerca volvulus 0.065 0.1706 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0119 0.0208 0.1774
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0119 0.0208 0.1774
Mycobacterium ulcerans heat shock protein 90 0.0127 0.0232 0.3738
Leishmania major histone deacetylase, putative 0.0074 0.0081 0.0354
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Schistosoma mansoni opsin-like receptor 0.0236 0.0538 0.0534
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0263 0.0614 1
Loa Loa (eye worm) hypothetical protein 0.0676 0.1782 0.2365
Echinococcus granulosus retinoic acid receptor rxr beta a 0.007 0.007 0.0079
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.017 0.0354 0.2055
Brugia malayi photoreceptor-specific nuclear receptor 0.007 0.007 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0364 0.5247
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0178 0.0375 0.0493
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0047 0.0004 0.0000088817
Schistosoma mansoni heat shock protein 0.0141 0.027 0.0266
Echinococcus granulosus G protein coupled receptor 139 0.0236 0.0538 0.0639
Plasmodium vivax histone deacetylase 2, putative 0.0074 0.0081 0.0058
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0236 0.0538 0.0644
Toxoplasma gondii PAN domain-containing protein 0.0157 0.0317 0.0398
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0063 0.005 0.006
Loa Loa (eye worm) hypothetical protein 0.0236 0.0538 0.0711
Echinococcus multilocularis histone deacetylase 6 0.0074 0.0081 0.0097
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.0622 0.9642
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0063 0.005 0.006
Brugia malayi latrophilin 2 splice variant baaae 0.1367 0.373 0.4957
Onchocerca volvulus 0.0236 0.0538 0.3138
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0236 0.0538 0.0711
Echinococcus multilocularis fmrfamide receptor 0.0236 0.0538 0.0644
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0178 0.0375 0.0443
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.007 0.007 0.0088

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 7.29 uM PubChem BioAssay. FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 17.9 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) = 34.2 uM PUBCHEM_BIOASSAY: Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) > 80 uM PUBCHEM_BIOASSAY: Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectivity Assay for Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) > 80 uM PUBCHEM_BIOASSAY: Dose Response orthogonal assay utilizing the direct end-point detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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