Detailed information for compound 1494818

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 545.625 | Formula: C28H39N3O8
  • H donors: 4 H acceptors: 5 LogP: 1.34 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC1CC(C)CC2=C(N)C(=O)C=C(C2=O)NC(=O)C(=CC=CC(C(C(=CC(C1O)C)C)OC(=O)N)OC)C
  • InChi: 1S/C28H39N3O8/c1-14-10-18-23(29)20(32)13-19(25(18)34)31-27(35)15(2)8-7-9-21(37-5)26(39-28(30)36)17(4)12-16(3)24(33)22(11-14)38-6/h7-9,12-14,16,21-22,24,26,33H,10-11,29H2,1-6H3,(H2,30,36)(H,31,35)
  • InChiKey: XYFFWTYOFPSZRM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Trypanosoma cruzi histone deacetylase 1, putative 0.0725 0.891 0.8907
Echinococcus multilocularis histone deacetylase 6 0.06 0.731 0.7308
Onchocerca volvulus 0.0067 0.0488 0.0777
Schistosoma mansoni adenoreceptor 0.0067 0.0488 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.6289 0.7005
Onchocerca volvulus Histone deacetylase 10 homolog 0.0352 0.4133 0.6571
Loa Loa (eye worm) hypothetical protein 0.0165 0.1742 0.1739
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0329 0.3843 0.3829
Schistosoma mansoni growth hormone secretagogue receptor 0.0067 0.0488 0.0479
Brugia malayi Histone deacetylase family protein 0.06 0.731 0.731
Schistosoma mansoni biogenic amine receptor 0.0067 0.0488 0.0479
Brugia malayi sulfakinin receptor protein 0.0067 0.0488 0.0488
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0521 0.6289 0.7005
Giardia lamblia Cysteine protease 0.0114 0.1086 0.0315
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0279 0.3196 0.3571
Toxoplasma gondii histone deacetylase HDAC4 0.0526 0.6363 0.7138
Entamoeba histolytica cysteine protease, putative 0.0279 0.3196 0.3509
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0131 0.1314 0.1305
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0521 0.6289 0.7052
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0067 0.0488 0.0479
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0311 0.0302
Leishmania major heat shock protein 83-1 0.011 0.1037 0.1141
Entamoeba histolytica cysteine protease, putative 0.0279 0.3196 0.3509
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0067 0.0488 0.0479
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0114 0.1086 0.0315
Trypanosoma brucei heat shock protein, putative 0.011 0.1037 0.1141
Plasmodium vivax unspecified product 0.0114 0.1086 0.121
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0229 0.0219
Loa Loa (eye worm) hypothetical protein 0.0356 0.418 0.4177
Entamoeba histolytica histone deacetylase, putative 0.0725 0.891 1
Echinococcus granulosus allatostatin A receptor 0.0067 0.0488 0.0479
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0067 0.0488 0.0484
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0279 0.3196 0.3468
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0114 0.1086 0.121
Schistosoma mansoni histone deacetylase hda2 0.0352 0.4133 0.4127
Brugia malayi G protein-coupled receptor F59B2.13 0.0067 0.0488 0.0488
Loa Loa (eye worm) histone deacetylase 1 0.0725 0.891 0.8909
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0521 0.6289 0.7005
Brugia malayi hypothetical protein 0.0085 0.072 0.072
Echinococcus multilocularis jun protein 0.0037 0.01 0.0091
Brugia malayi Cathepsin L-like cysteine proteinase 0.0356 0.418 0.418
Trypanosoma cruzi prolyl endopeptidase 0.0131 0.1314 0.1294
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Echinococcus multilocularis histone deacetylase 6 0.06 0.731 0.7308
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0488 0.0479
Echinococcus granulosus neuropeptides capa receptor 0.0067 0.0488 0.0479
Echinococcus granulosus Polycystic kidney disease protein 0.0085 0.072 0.0711
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0311 0.0302
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0107 0.0097
Loa Loa (eye worm) histone deacetylase 0.06 0.731 0.7309
Trypanosoma brucei heat shock protein, putative 0.011 0.1037 0.1141
Toxoplasma gondii GNS1/SUR4 family protein 0.0034 0.0072 0.007
Loa Loa (eye worm) hypothetical protein 0.0053 0.0311 0.0307
Giardia lamblia Cathepsin L precursor 0.0114 0.1086 0.0315
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0867 0.0858
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0114 0.1086 0.1056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0488 0.0479
Leishmania major cathepsin L-like protease 0.0521 0.6289 0.7052
Trypanosoma brucei heat shock protein, putative 0.011 0.1037 0.1141
Onchocerca volvulus 0.0067 0.0488 0.0777
Onchocerca volvulus 0.0521 0.6289 1
Brugia malayi neuropeptide F receptor 0.0067 0.0488 0.0488
Onchocerca volvulus 0.0521 0.6289 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0114 0.1086 0.121
Echinococcus multilocularis sex peptide receptor 0.0067 0.0488 0.0479
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1396 0.1388
Trypanosoma cruzi cruzipain precursor, putative 0.0165 0.1742 0.1724
Loa Loa (eye worm) cysteine protease 0.0521 0.6289 0.6288
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0067 0.0488 0.0479
Giardia lamblia Grp94/Hsp90 0.0098 0.0891 0.0073
Brugia malayi cathepsin F-like cysteine proteinase 0.0114 0.1086 0.1086
Echinococcus granulosus tar DNA binding protein 0.0062 0.0427 0.0418
Plasmodium vivax endoplasmin, putative 0.011 0.1037 0.1154
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0053 0.0309 0.0491
Trypanosoma cruzi fatty acid elongase, putative 0.0034 0.0072 0.005
Plasmodium vivax multidomain scavenger receptor, putative 0.0085 0.072 0.0798
Schistosoma mansoni hypothetical protein 0.0041 0.0159 0.015
Toxoplasma gondii heat shock protein 75, putative 0.0053 0.0309 0.0336
Echinococcus multilocularis neuropeptide FF receptor 2 0.0067 0.0488 0.0479
Plasmodium vivax histone deacetylase, putative 0.0526 0.6363 0.7138
Brugia malayi Cathepsin L-like precursor 0.0521 0.6289 0.6289
Onchocerca volvulus 0.0067 0.0488 0.0777
Onchocerca volvulus 0.0047 0.0229 0.0364
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0067 0.0488 0.0484
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0114 0.1086 0.1197
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0249 0.0244
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0163 0.0153
Trypanosoma brucei heat shock protein, putative 0.011 0.1037 0.1141
Loa Loa (eye worm) heat shock protein 75 0.0053 0.0309 0.0304
Brugia malayi Hsp90 protein 0.0053 0.0309 0.0309
Brugia malayi cathepsin L-like precursor 0.0356 0.418 0.418
Echinococcus granulosus biogenic amine 5HT receptor 0.0067 0.0488 0.0479
Loa Loa (eye worm) hypothetical protein 0.0114 0.1086 0.1082
Brugia malayi Pre-SET motif family protein 0.0029 0.001 0.001
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0329 0.3843 0.3837
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0521 0.6289 0.7005
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Leishmania major heat shock protein 83-1 0.011 0.1037 0.1141
Plasmodium vivax histone deacetylase 2, putative 0.06 0.731 0.8203
Brugia malayi Papain family cysteine protease containing protein 0.0114 0.1086 0.1086
Brugia malayi Fatty acid elongation protein 3 0.0034 0.0072 0.0072
Onchocerca volvulus Cathepsin L homolog 0.0521 0.6289 1
Trypanosoma cruzi histone deacetylase, putative 0.0352 0.4133 0.412
Onchocerca volvulus Neuropeptide F receptor homolog 0.0067 0.0488 0.0777
Trichomonas vaginalis heat shock protein, putative 0.011 0.1037 0.0999
Plasmodium falciparum fatty acid elongation protein, GNS1/SUR4 family, putative 0.0034 0.0072 0.0056
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0114 0.1086 0.1078
Echinococcus granulosus tm gpcr rhodopsin 0.0067 0.0488 0.0479
Brugia malayi cathepsin Z-like cysteine proteinase 0.0114 0.1086 0.1086
Entamoeba histolytica heat shock protein 90, putative 0.011 0.1037 0.1056
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0067 0.0488 0.0479
Schistosoma mansoni biogenic amine (5HT) receptor 0.0067 0.0488 0.0479
Brugia malayi hypothetical protein 0.0085 0.072 0.072
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0229 0.0364
Leishmania major cathepsin L-like protease 0.0521 0.6289 0.7052
Schistosoma mansoni biogenic amine (5HT) receptor 0.0067 0.0488 0.0479
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0052 0.0301 0.0314
Toxoplasma gondii histone deacetylase HDAC1 0.06 0.731 0.8203
Echinococcus multilocularis cathepsin L 0.0279 0.3196 0.3189
Schistosoma mansoni histone deacetylase 4 5 0.06 0.731 0.7308
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0114 0.1086 0.1056
Echinococcus multilocularis neuropeptides capa receptor 0.0067 0.0488 0.0479
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0114 0.1086 0.1078
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0067 0.0488 0.0479
Entamoeba histolytica cysteine protease, putative 0.0279 0.3196 0.3509
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0067 0.0488 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.6289 0.7005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0067 0.0488 0.0479
Echinococcus granulosus tachykinin peptides receptor 99D 0.0809 0.9972 0.9972
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.6289 0.7005
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0329 0.3843 0.4299
Schistosoma mansoni loxhd1 0.0085 0.072 0.0711
Plasmodium falciparum histone deacetylase, putative 0.06 0.731 0.8201
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0067 0.0488 0.0479
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0427 0.0418
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0521 0.6289 0.7005
Echinococcus multilocularis heat shock protein 90 0.011 0.1037 0.1028
Echinococcus multilocularis histone deacetylase 6 0.062 0.756 0.7557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.6289 0.7005
Brugia malayi Pre-SET motif family protein 0.0205 0.2258 0.2258
Leishmania major cathepsin L-like protease 0.0521 0.6289 0.7052
Trypanosoma cruzi histone deacetylase, putative 0.06 0.731 0.7304
Trypanosoma cruzi heat shock protein 85, putative 0.0094 0.0832 0.0812
Giardia lamblia Cathepsin B precursor 0.0329 0.3843 0.3728
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.6289 0.7005
Brugia malayi histone deacetylase 1 (HD1) 0.0725 0.891 0.891
Toxoplasma gondii prolyl endopeptidase 0.0131 0.1314 0.1465
Onchocerca volvulus 0.0085 0.072 0.1144
Echinococcus granulosus cathepsin b 0.0811 1 1
Leishmania major heat shock protein 83-1 0.011 0.1037 0.1141
Plasmodium vivax serine-repeat antigen (SERA) 0.0114 0.1086 0.121
Echinococcus multilocularis lipoxygenase domain containing protein 0.0085 0.072 0.0711
Echinococcus granulosus neuropeptide receptor 0.0067 0.0488 0.0479
Brugia malayi histone deacetylase 3 (HD3) 0.0725 0.891 0.891
Brugia malayi Cathepsin L-like precursor 0.0521 0.6289 0.6289
Trypanosoma brucei histone deacetylase 3 0.06 0.731 0.8201
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0114 0.1086 0.1078
Trypanosoma brucei cysteine peptidase C (CPC) 0.0329 0.3843 0.4299
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0037 0.01 0.0091
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0163 0.0153
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0018
Brugia malayi Dopamine receptor 0.0067 0.0488 0.0488
Echinococcus granulosus RUN 0.0085 0.072 0.0711
Entamoeba histolytica cysteine proteinase, putative 0.0521 0.6289 0.7023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0249 0.0239
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0249 0.0239
Echinococcus multilocularis protein dispatched 1 0.0047 0.0237 0.0228
Plasmodium falciparum histone deacetylase 2 0.06 0.731 0.8201
Echinococcus granulosus expressed conserved protein 0.0091 0.0792 0.0783
Echinococcus multilocularis cathepsin b 0.0811 1 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0279 0.3196 0.3468
Brugia malayi cathepsin Z-like cysteine proteinase 0.0114 0.1086 0.1086
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0067 0.0488 0.0484
Echinococcus multilocularis cathepsin L 0.0114 0.1086 0.1078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0521 0.6289 0.7005
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0521 0.6289 0.6286
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0165 0.1742 0.1742
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0229 0.0219
Schistosoma mansoni amine GPCR 0.0067 0.0488 0.0479
Trypanosoma cruzi histone deacetylase, putative 0.06 0.731 0.7304
Onchocerca volvulus 0.0521 0.6289 1
Schistosoma mansoni lipoxygenase 0.0508 0.6132 0.6128
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Schistosoma mansoni polycystin 1-related 0.0085 0.072 0.0711
Brugia malayi follicle stimulating hormone receptor 0.0067 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Onchocerca volvulus 0.0067 0.0488 0.0777
Entamoeba histolytica cysteine protease, putative 0.0279 0.3196 0.3509
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0067 0.0488 0.0479
Trypanosoma cruzi cysteine protease, putative 0.0279 0.3196 0.318
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Echinococcus multilocularis RUN 0.0085 0.072 0.0711
Trichomonas vaginalis histone deacetylase, putative 0.0725 0.891 1
Leishmania major histone deacetylase, putative 0.06 0.731 0.8201
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0114 0.1086 0.0315
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0067 0.0488 0.0479
Schistosoma mansoni heat shock protein 0.011 0.1037 0.1028
Brugia malayi GNS1/SUR4 family protein 0.0034 0.0072 0.0072
Leishmania major heat shock protein 83-1 0.011 0.1037 0.1141
Leishmania major heat shock protein 83-1 0.011 0.1037 0.1141
Plasmodium vivax vivapain-2 0.0521 0.6289 0.7056
Echinococcus granulosus dro:myosuppressin receptor 0.0067 0.0488 0.0479
Schistosoma mansoni hypothetical protein 0.0283 0.3255 0.3248
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0488 0.0479
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0114 0.1086 0.0315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.6289 0.7005
Brugia malayi Cathepsin L-like precursor 0.0521 0.6289 0.6289
Brugia malayi Dopamine receptor protein 1 0.0067 0.0488 0.0488
Leishmania major histone deacetylase, putative 0.06 0.731 0.8201
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0067 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0067 0.0488 0.0479
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Echinococcus granulosus cathepsin L cysteine proteinase 0.0521 0.6289 0.6286
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0067 0.0488 0.0479
Onchocerca volvulus 0.0521 0.6289 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0488 0.0479
Schistosoma mansoni cathepsin S (C01 family) 0.0114 0.1086 0.1078
Toxoplasma gondii cathepsin B 0.0329 0.3843 0.4307
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0725 0.891 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0488 0.0479
Echinococcus multilocularis heat shock protein 0.011 0.1037 0.1028
Loa Loa (eye worm) hypothetical protein 0.0356 0.418 0.4177
Echinococcus granulosus cathepsin L cysteine protease 0.0279 0.3196 0.3189
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0114 0.1086 0.1086
Brugia malayi hypothetical protein 0.0037 0.0107 0.0107
Echinococcus granulosus neuropeptide receptor A26 0.0067 0.0488 0.0479
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0163 0.0153
Echinococcus multilocularis tumor protein p63 0.0331 0.3868 0.3862
Brugia malayi putative neuropeptide receptor NPR1 0.0067 0.0488 0.0488
Echinococcus multilocularis cysteine protease 0.0521 0.6289 0.6286
Plasmodium falciparum heat shock protein 90, putative 0.0048 0.025 0.0256
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0052 0.0301 0.028
Loa Loa (eye worm) MBCTL1 0.0053 0.0311 0.0307
Echinococcus granulosus cathepsin l1 0.0521 0.6289 0.6286
Trypanosoma cruzi histone deacetylase 1, putative 0.0725 0.891 0.8907
Loa Loa (eye worm) fatty acid elongation protein 3 0.0034 0.0072 0.0068
Brugia malayi cathepsin L precursor 0.0114 0.1086 0.1086
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0114 0.1086 0.1197
Brugia malayi Papain family cysteine protease containing protein 0.0279 0.3196 0.3196
Leishmania major fatty acid elongase, putative 0.0034 0.0072 0.0056
Echinococcus granulosus g protein coupled receptor 0.0067 0.0488 0.0479
Schistosoma mansoni hypothetical protein 0.004 0.0143 0.0134
Giardia lamblia Cathepsin B precursor 0.0329 0.3843 0.3728
Trypanosoma brucei Heat shock protein 83, putative 0.011 0.1037 0.1141
Toxoplasma gondii integral membrane protein, GNS1/SUR4 family protein, putative 0.0034 0.0072 0.007
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0067 0.0488 0.0479
Brugia malayi Cathepsin L-like precursor 0.0521 0.6289 0.6289
Brugia malayi Histone deacetylase 1 0.0725 0.891 0.891
Loa Loa (eye worm) GNS1/SUR4 family protein 0.0034 0.0072 0.0068
Echinococcus multilocularis prolyl endopeptidase 0.0131 0.1314 0.1305
Echinococcus granulosus histone deacetylase 7 0.06 0.731 0.7308
Brugia malayi RNA binding protein 0.0062 0.0427 0.0427
Brugia malayi mbt repeat family protein 0.0047 0.0229 0.0229
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0311 0.0302
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0114 0.1086 0.121
Echinococcus multilocularis fmrfamide receptor 0.0067 0.0488 0.0479
Leishmania major heat shock protein 83-1 0.011 0.1037 0.1141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.6289 0.7005
Leishmania major heat shock protein 83-1 0.011 0.1037 0.1141
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0427 0.0418
Loa Loa (eye worm) histone deacetylase 3 0.0725 0.891 0.8909
Echinococcus granulosus alpha 1A adrenergic receptor 0.0067 0.0488 0.0479
Echinococcus multilocularis histone deacetylase 7 0.06 0.731 0.7308
Schistosoma mansoni histamine h1 receptor 0.0067 0.0488 0.0479
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0229 0.0219
Toxoplasma gondii cathepsin CPC2 0.0114 0.1086 0.121
Entamoeba histolytica cysteine protease, putative 0.0114 0.1086 0.1113
Brugia malayi Papain family cysteine protease containing protein 0.0279 0.3196 0.3196
Brugia malayi Doublecortin family protein 0.0085 0.072 0.072
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0114 0.1086 0.1082
Trypanosoma brucei heat shock protein, putative 0.011 0.1037 0.1141
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Trichomonas vaginalis heat shock protein, putative 0.0098 0.0891 0.0833
Schistosoma mansoni amine GPCR 0.0067 0.0488 0.0479
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0067 0.0488 0.0484
Schistosoma mansoni biogenic amine receptor 0.0067 0.0488 0.0479
Entamoeba histolytica cysteine protease, putative 0.0279 0.3196 0.3509
Echinococcus multilocularis neuropeptide Y receptor 0.0067 0.0488 0.0479
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0521 0.6289 0.7052
Trypanosoma brucei oligopeptidase b 0.0052 0.0301 0.0314
Plasmodium vivax histone deacetylase, putative 0.06 0.731 0.8203
Schistosoma mansoni histone deacetylase 1 2 3 0.0352 0.4133 0.4127
Schistosoma mansoni cathepsin s 0.0165 0.1742 0.1735
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0725 0.891 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0488 0.0479
Entamoeba histolytica cysteine proteinase, putative 0.0521 0.6289 0.7023
Brugia malayi Cathepsin L-like precursor 0.0356 0.418 0.418
Trichomonas vaginalis histone deacetylase, putative 0.0725 0.891 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0114 0.1086 0.1197
Leishmania major heat shock protein 83-1 0.011 0.1037 0.1141
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0521 0.6289 0.7052
Entamoeba histolytica cysteine protease, putative 0.0279 0.3196 0.3509
Schistosoma mansoni heat shock protein 0.011 0.1037 0.1028
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0249 0.0249
Schistosoma mansoni alpha-1 adrenergic receptor 0.0067 0.0488 0.0479
Trichomonas vaginalis heat shock protein, putative 0.0048 0.025 0.01
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0114 0.1086 0.1056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0488 0.0479
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0488 0.0479
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Echinococcus multilocularis cathepsin b 0.0811 1 1
Echinococcus multilocularis histone deacetylase 1 0.0725 0.891 0.8909
Echinococcus granulosus tm gpcr rhodopsin 0.0067 0.0488 0.0479
Entamoeba histolytica heat shock protein 90, putative 0.011 0.1037 0.1056
Giardia lamblia Cathepsin B precursor 0.0329 0.3843 0.3728
Brugia malayi Tachykinin-like peptides receptor 99D 0.0067 0.0488 0.0488
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0159 0.0159
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0725 0.891 1
Entamoeba histolytica cysteine protease, putative 0.0279 0.3196 0.3509
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0521 0.6289 0.7052
Loa Loa (eye worm) fibroinase 0.0521 0.6289 0.6288
Leishmania major heat shock protein 83-1 0.011 0.1037 0.1141
Trichomonas vaginalis heat shock protein, putative 0.0064 0.0454 0.0334
Trypanosoma cruzi cysteine peptidase, putative 0.0521 0.6289 0.6281
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Loa Loa (eye worm) hypothetical protein 0.0725 0.891 0.8909
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0184 0.1981 0.1973
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0488 0.0479
Trypanosoma brucei heat shock protein, putative 0.011 0.1037 0.1141
Echinococcus granulosus cathepsin L 0.0114 0.1086 0.1078
Loa Loa (eye worm) TYRA-2 protein 0.0067 0.0488 0.0484
Brugia malayi hypothetical protein 0.003 0.0022 0.0022
Brugia malayi GnHR receptor homolog 0.0067 0.0488 0.0488
Trypanosoma cruzi heat shock protein 90, putative 0.011 0.1037 0.1017
Trichomonas vaginalis endoplasmin, putative 0.0064 0.0454 0.0334
Plasmodium vivax unspecified product 0.0279 0.3196 0.358
Trypanosoma cruzi fatty acid elongase, putative 0.0034 0.0072 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.6289 0.7005
Brugia malayi Serotonin receptor 0.0067 0.0488 0.0488
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0521 0.6289 0.6288
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0249 0.0239
Giardia lamblia Cathepsin L precursor 0.0114 0.1086 0.0315
Toxoplasma gondii preprocathepsin c precursor, putative 0.0114 0.1086 0.121
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0488 0.0479
Trypanosoma cruzi heat shock protein 90, putative 0.0094 0.0832 0.0812
Trypanosoma cruzi histone deacetylase, putative 0.06 0.731 0.7304
Loa Loa (eye worm) heat shock protein 90 0.011 0.1037 0.1032
Schistosoma mansoni cathepsin F (C01 family) 0.0356 0.418 0.4174
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0795 0.9796 0.9795
Loa Loa (eye worm) hypothetical protein 0.0114 0.1086 0.1082
Loa Loa (eye worm) histone deacetylase 11 0.0526 0.6363 0.6361
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0521 0.6289 0.7005
Brugia malayi RE15519p 0.0067 0.0488 0.0488
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0488 0.0479
Plasmodium vivax heat shock protein 90, putative 0.0053 0.0309 0.0336
Loa Loa (eye worm) hypothetical protein 0.0096 0.0867 0.0863
Echinococcus granulosus heat shock protein 90 0.011 0.1037 0.1028
Loa Loa (eye worm) endoplasmin 0.011 0.1037 0.1032
Toxoplasma gondii cathepsin CPC1 0.0114 0.1086 0.121
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0067 0.0488 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0356 0.418 0.4593
Brugia malayi larval opioid receptor 0.0067 0.0488 0.0488
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0067 0.0488 0.0479
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0098 0.0891 1
Brugia malayi Cathepsin L-like precursor 0.0356 0.418 0.418
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1396 0.1388
Schistosoma mansoni opsin-like receptor 0.0067 0.0488 0.0479
Toxoplasma gondii cathepsin CPL 0.0521 0.6289 0.7056
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0427 0.0427
Echinococcus granulosus cathepsin l cysteine peptidase 0.0521 0.6289 0.6286
Loa Loa (eye worm) hypothetical protein 0.0048 0.0253 0.0248
Loa Loa (eye worm) melatonin receptor type 1A 0.0067 0.0488 0.0484
Schistosoma mansoni hypothetical protein 0.0067 0.0488 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0329 0.3843 0.4208
Schistosoma mansoni jun-related protein 0.003 0.0013 0.0003
Plasmodium falciparum serine repeat antigen 5 0.0114 0.1086 0.1197
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0427 0.0423
Brugia malayi Serotonin receptor 0.0067 0.0488 0.0488
Echinococcus granulosus somatostatin receptor 0.0067 0.0488 0.0479
Onchocerca volvulus 0.0067 0.0488 0.0777
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0114 0.1086 0.1078
Schistosoma mansoni cathepsin F (C01 family) 0.0521 0.6289 0.6286
Giardia lamblia Cathepsin B precursor 0.0114 0.1086 0.0315
Schistosoma mansoni cathepsin C 0.0114 0.1086 0.1078
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0114 0.1086 0.1078
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0114 0.1086 0.121
Schistosoma mansoni hypothetical protein 0.0205 0.225 0.2242
Entamoeba histolytica cysteine protease, putative 0.0114 0.1086 0.1113
Onchocerca volvulus 0.0521 0.6289 1
Schistosoma mansoni neuropeptide receptor 0.0067 0.0488 0.0479
Plasmodium vivax heat shock protein 86, putative 0.011 0.1037 0.1154
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0249 0.0239
Loa Loa (eye worm) hypothetical protein 0.0114 0.1086 0.1082
Plasmodium vivax serine-repeat antigen (SERA) 0.0114 0.1086 0.121
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0067 0.0488 0.0479
Leishmania major histone deacetylase, putative 0.0725 0.891 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0067 0.0488 0.0479
Echinococcus granulosus histone deacetylase 6 0.06 0.731 0.7308
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0114 0.1086 0.121
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0521 0.6289 0.7005
Echinococcus granulosus cathepsin b 0.0811 1 1
Echinococcus multilocularis allatostatin A receptor 0.0067 0.0488 0.0479
Giardia lamblia Cathepsin L precursor 0.0114 0.1086 0.0315
Brugia malayi hypothetical protein 0.0067 0.0488 0.0488
Echinococcus granulosus lipoxygenase domain containing protein 0.0085 0.072 0.0711
Brugia malayi AKH receptor 0.0067 0.0488 0.0488
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0488 0.0479
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1086 0.1056
Brugia malayi mbt repeat family protein 0.0047 0.0229 0.0229
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0114 0.1086 0.121
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Giardia lamblia Cathepsin L-like protease 0.0114 0.1086 0.0315
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0279 0.3196 0.3189
Schistosoma mansoni amine GPCR 0.0067 0.0488 0.0479
Loa Loa (eye worm) doublecortin family protein 0.0085 0.072 0.0715
Trypanosoma cruzi oligopeptidase b 0.0052 0.0301 0.028
Plasmodium falciparum LCCL domain-containing protein 0.0085 0.072 0.0785
Leishmania major fatty acid elongase, putative 0.0034 0.0072 0.0056
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0067 0.0488 0.0488
Trypanosoma cruzi histone deacetylase, putative 0.0352 0.4133 0.412
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0037 0.01 0.0091
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Schistosoma mansoni cathepsin B (C01 family) 0.0114 0.1086 0.1078
Trypanosoma cruzi oligopeptidase b 0.0052 0.0301 0.028
Echinococcus granulosus heat shock protein 0.011 0.1037 0.1028
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0165 0.1742 0.1739
Trypanosoma brucei histone deacetylase 2 0.0352 0.4133 0.4625
Echinococcus multilocularis histone deacetylase 8 0.0352 0.4133 0.4127
Leishmania major heat shock protein 83-1 0.011 0.1037 0.1141
Echinococcus granulosus orexin receptor type 2 0.0067 0.0488 0.0479
Echinococcus multilocularis histone deacetylase 0.06 0.731 0.7308
Plasmodium falciparum serine repeat antigen 3 0.0114 0.1086 0.1197
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0427 0.0418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.6289 0.7005
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0114 0.1086 0.1113
Brugia malayi Papain family cysteine protease containing protein 0.0114 0.1086 0.1086
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0114 0.1086 0.1056
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0067 0.0488 0.0479
Trichomonas vaginalis histone deacetylase, putative 0.0725 0.891 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0521 0.6289 0.7052
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0229 0.0219
Loa Loa (eye worm) hypothetical protein 0.0356 0.418 0.4177
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2258 0.2255
Trichomonas vaginalis histone deacetylase, putative 0.0725 0.891 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0403 0.0399
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0067 0.0488 0.0479
Schistosoma mansoni histone deacetylase 4 5 0.06 0.731 0.7308
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0521 0.6289 0.7005
Schistosoma mansoni neuropeptide receptor 0.0067 0.0488 0.0479
Echinococcus granulosus histone deacetylase 0.06 0.731 0.7308
Echinococcus multilocularis histone deacetylase 3 0.0725 0.891 0.8909
Echinococcus granulosus serotonin receptor 0.0067 0.0488 0.0479
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Plasmodium vivax vivapain-2 0.0521 0.6289 0.7056
Plasmodium falciparum long chain fatty acid elongation enzyme, putative 0.0034 0.0072 0.0056
Trypanosoma brucei heat shock protein, putative 0.011 0.1037 0.1141
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0114 0.1086 0.1078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0521 0.6289 0.7052
Loa Loa (eye worm) RNA binding protein 0.0062 0.0427 0.0423
Plasmodium vivax heat shock protein, putative 0.0053 0.0309 0.0336
Echinococcus multilocularis G protein coupled receptor 139 0.0067 0.0488 0.0479
Entamoeba histolytica cysteine protease, putative 0.0114 0.1086 0.1113
Brugia malayi Integrin beta pat-3 precursor 0.0185 0.1999 0.1999
Brugia malayi G-protein coupled receptor 0.0067 0.0488 0.0488
Trypanosoma cruzi cysteine proteinase, putative 0.0279 0.3196 0.318
Brugia malayi hypothetical protein 0.0067 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Loa Loa (eye worm) hypothetical protein 0.0165 0.1742 0.1739
Entamoeba histolytica cysteine protease, putative 0.0114 0.1086 0.1113
Schistosoma mansoni rab6-interacting 0.0085 0.072 0.0711
Trypanosoma brucei histone deacetylase, putative 0.06 0.731 0.8201
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0118 0.1137 1
Schistosoma mansoni hypothetical protein 0.0205 0.225 0.2242
Schistosoma mansoni neuropeptide F-like receptor 0.0067 0.0488 0.0479
Giardia lamblia Hypothetical protein 0.0114 0.1086 0.0315
Echinococcus granulosus fmrfamide receptor 0.0067 0.0488 0.0479
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0114 0.1086 0.121
Trypanosoma cruzi cysteine proteinase, putative 0.0279 0.3196 0.318
Leishmania major cathepsin L-like protease 0.0521 0.6289 0.7052
Schistosoma mansoni myosin xvIII 0.0067 0.0488 0.0479
Echinococcus multilocularis cysteine protease 0.0521 0.6289 0.6286
Treponema pallidum heat shock protein 90 0.0098 0.0891 0.5
Echinococcus granulosus histone deacetylase 3 0.0725 0.891 0.8909
Trichomonas vaginalis histone deacetylase, putative 0.0725 0.891 1
Schistosoma mansoni hypothetical protein 0.0085 0.072 0.0711
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0521 0.6289 0.7005
Toxoplasma gondii heat shock protein 90, putative 0.011 0.1037 0.1154
Onchocerca volvulus 0.0067 0.0488 0.0777
Trypanosoma brucei prolyl oligopeptidase, putative 0.0052 0.0301 0.0314
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0022 0.0014
Trypanosoma cruzi fatty acid elongase, putative 0.0034 0.0072 0.005
Brugia malayi Papain family cysteine protease containing protein 0.0521 0.6289 0.6289
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0521 0.6289 0.6288
Entamoeba histolytica cysteine proteinase, putative 0.0279 0.3196 0.3509
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0279 0.3196 0.3571
Echinococcus granulosus neuropeptide FF receptor 2 0.0067 0.0488 0.0479
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0488 0.0479
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0184 0.1981 0.1973
Schistosoma mansoni hypothetical protein 0.0067 0.0488 0.0479
Trypanosoma cruzi major cysteine proteinase, putative 0.0114 0.1086 0.1066
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0867 0.0867
Schistosoma mansoni hypothetical protein 0.004 0.0143 0.0134
Entamoeba histolytica cysteine protease, putative 0.0279 0.3196 0.3509
Schistosoma mansoni cathepsin F (C01 family) 0.0521 0.6289 0.6286
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0114 0.1086 0.1056
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0229 0.0219
Schistosoma mansoni opsin-like receptor 0.0067 0.0488 0.0479
Plasmodium falciparum cysteine proteinase falcipain 3 0.0521 0.6289 0.7052
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2621 0.2811
Echinococcus granulosus cysteine protease 0.0279 0.3196 0.3189
Onchocerca volvulus 0.0067 0.0488 0.0777
Leishmania major fatty acid elongase, putative 0.0034 0.0072 0.0056
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0811 1 1
Onchocerca volvulus 0.0085 0.072 0.1144
Onchocerca volvulus Prolyl endopeptidase homolog 0.0131 0.1314 0.2089
Onchocerca volvulus 0.0067 0.0488 0.0777
Loa Loa (eye worm) hypothetical protein 0.0811 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0114 0.1086 0.1056
Brugia malayi G-protein coupled receptor 0.0067 0.0488 0.0488
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0067 0.0488 0.0479
Echinococcus granulosus cathepsin L 0.0279 0.3196 0.3189
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0067 0.0488 0.0479
Leishmania major heat shock protein 83-1 0.011 0.1037 0.1141
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0521 0.6289 0.7052
Brugia malayi bZIP transcription factor family protein 0.0037 0.01 0.01
Schistosoma mansoni patched 1 0.0041 0.0163 0.0153
Schistosoma mansoni hypothetical protein 0.0067 0.0488 0.0479
Toxoplasma gondii histone deacetylase HDAC2 0.0725 0.891 1
Leishmania major oligopeptidase b 0.0052 0.0301 0.0314
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0098 0.0891 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0114 0.1086 0.1056
Schistosoma mansoni heat shock protein 0.0053 0.0309 0.0299
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0403 0.0403
Entamoeba histolytica cysteine protease, putative 0.0279 0.3196 0.3509
Onchocerca volvulus Cathepsin L homolog 0.0521 0.6289 1
Echinococcus multilocularis neuropeptide s receptor 0.0067 0.0488 0.0479
Trichomonas vaginalis histone deacetylase, putative 0.0725 0.891 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0488 0.0479
Echinococcus multilocularis serotonin receptor 0.0067 0.0488 0.0479
Echinococcus multilocularis neuropeptide receptor 0.0067 0.0488 0.0479
Plasmodium falciparum heat shock protein 90, putative 0.0053 0.0309 0.0322
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0488 0.0479
Schistosoma mansoni opsin-like receptor 0.0067 0.0488 0.0479
Echinococcus multilocularis lipoxygenase domain containing protein 0.0085 0.072 0.0711
Leishmania major cathepsin L-like protease 0.0521 0.6289 0.7052
Brugia malayi Cathepsin L-like precursor 0.0521 0.6289 0.6289
Schistosoma mansoni hypothetical protein 0.0037 0.0107 0.0097
Plasmodium vivax unspecified product 0.0165 0.1742 0.1947
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0114 0.1086 0.1082
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0131 0.1314 0.1305
Echinococcus granulosus lipoxygenase domain containing protein 0.0085 0.072 0.0711
Leishmania major heat shock protein 83-1 0.011 0.1037 0.1141
Loa Loa (eye worm) cathepsin B 0.0329 0.3843 0.384
Entamoeba histolytica cysteine proteinase, putative 0.0279 0.3196 0.3509
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0249 0.0239
Plasmodium falciparum serine repeat antigen 1 0.0114 0.1086 0.1197
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0521 0.6289 0.7005
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0508 0.6132 0.6128
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0249 0.0239
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0253 0.0243
Trypanosoma cruzi cysteine peptidase, putative 0.0521 0.6289 0.6281
Brugia malayi hypothetical protein 0.0029 0.0005 0.0005
Onchocerca volvulus 0.0029 0.001 0.0015
Schistosoma mansoni histone deacetylase 0.0725 0.891 0.8909
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Echinococcus granulosus integrin beta 2 0.0135 0.1365 0.1357
Leishmania major heat shock protein 83-1 0.011 0.1037 0.1141
Loa Loa (eye worm) hypothetical protein 0.0029 0.001 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0356 0.418 0.4593
Loa Loa (eye worm) hypothetical protein 0.0248 0.281 0.2807
Brugia malayi Melatonin receptor type 1A 0.0067 0.0488 0.0488
Echinococcus multilocularis g-protein coupled receptor 0.0067 0.0488 0.0479
Loa Loa (eye worm) hypothetical protein 0.0114 0.1086 0.1082
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0279 0.3196 0.3189
Leishmania major heat shock protein, putative 0.0053 0.0309 0.0322
Trichomonas vaginalis heat shock protein, putative 0.0098 0.0891 0.0833
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0107 0.0097
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0488 0.0479
Brugia malayi hypothetical protein 0.0067 0.0488 0.0488
Schistosoma mansoni histone deacetylase 0.0725 0.891 0.8909
Loa Loa (eye worm) hypothetical protein 0.0085 0.072 0.0715
Brugia malayi cathepsin F-like cysteine proteinase 0.0165 0.1742 0.1742
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0521 0.6289 0.7052
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0067 0.0488 0.0488
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0867 0.0858
Schistosoma mansoni amine GPCR 0.0067 0.0488 0.0479
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0067 0.0488 0.0479
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0098 0.0891 0.0977
Brugia malayi Cathepsin L-like precursor 0.0521 0.6289 0.6289
Loa Loa (eye worm) hypothetical protein 0.0131 0.1314 0.131
Entamoeba histolytica cysteine proteinase, putative 0.0279 0.3196 0.3509
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1086 0.1056
Entamoeba histolytica cysteine protease, putative 0.0279 0.3196 0.3509
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0279 0.3196 0.318
Echinococcus granulosus hypothetical protein 0.0067 0.0488 0.0479
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0356 0.418 0.4167
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0114 0.1086 0.1056
Entamoeba histolytica cysteine proteinase, putative 0.0356 0.418 0.4627
Echinococcus multilocularis cathepsin L cysteine protease 0.0521 0.6289 0.6286
Onchocerca volvulus 0.0067 0.0488 0.0777
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0067 0.0488 0.0479
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0488 0.0479
Trypanosoma cruzi fatty acid elongase, putative 0.0034 0.0072 0.005
Echinococcus granulosus neuropeptide s receptor 0.0067 0.0488 0.0479
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0114 0.1086 0.121
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0811 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0521 0.6289 0.6281
Schistosoma mansoni hypothetical protein 0.003 0.0013 0.0003
Onchocerca volvulus 0.0067 0.0488 0.0777
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0114 0.1086 0.1056
Loa Loa (eye worm) hypothetical protein 0.0114 0.1086 0.1082
Leishmania major cysteine peptidase A (CPA) 0.0521 0.6289 0.7052
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0427 0.0418
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0811 1 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0279 0.3196 0.3509
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Echinococcus granulosus jun protein 0.0037 0.01 0.0091
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0067 0.0488 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0114 0.1086 0.1056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.6289 0.7005
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0131 0.1314 0.1453
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0311 0.0311
Trypanosoma cruzi major cysteine proteinase, putative 0.0114 0.1086 0.1066
Trypanosoma brucei histone deacetylase 4 0.06 0.731 0.8201
Onchocerca volvulus Cathepsin F homolog 0.0521 0.6289 1
Trypanosoma brucei heat shock protein 84, putative 0.0053 0.0309 0.0322
Echinococcus granulosus neuropeptide Y receptor 0.0067 0.0488 0.0479
Onchocerca volvulus 0.0067 0.0488 0.0777
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0811 1 1
Giardia lamblia Hypothetical protein 0.0114 0.1086 0.0315
Echinococcus granulosus prolyl endopeptidase 0.0131 0.1314 0.1305
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Giardia lamblia Cathepsin L-like protease 0.0114 0.1086 0.0315
Echinococcus multilocularis somatostatin receptor 0.0067 0.0488 0.0479
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0114 0.1086 0.1078
Brugia malayi histone deacetylase 11 0.0526 0.6363 0.6363
Giardia lamblia Histone deacetylase 0.0725 0.891 1
Onchocerca volvulus 0.0521 0.6289 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0067 0.0488 0.0479
Plasmodium falciparum serine repeat antigen 6 0.0114 0.1086 0.1197
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Brugia malayi hypothetical protein 0.0067 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Giardia lamblia Heat shock protein HSP 90-alpha 0.011 0.1037 0.0253
Loa Loa (eye worm) G-protein coupled receptor 0.0067 0.0488 0.0484
Plasmodium falciparum serine repeat antigen 8 0.0114 0.1086 0.1197
Plasmodium falciparum serine repeat antigen 9 0.0114 0.1086 0.1197
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0067 0.0488 0.0479
Plasmodium falciparum cysteine proteinase falcipain 1 0.0279 0.3196 0.3571
Echinococcus granulosus neuropeptide Y receptor 0.0067 0.0488 0.0479
Loa Loa (eye worm) hypothetical protein 0.0041 0.0159 0.0155
Loa Loa (eye worm) histone deacetylase 7A 0.06 0.731 0.7309
Echinococcus granulosus g protein coupled receptor 0.0067 0.0488 0.0479
Plasmodium falciparum serine repeat antigen 2 0.0114 0.1086 0.1197
Trypanosoma cruzi Heat shock protein 83, putative 0.011 0.1037 0.1017
Echinococcus multilocularis expressed conserved protein 0.0091 0.0792 0.0783
Loa Loa (eye worm) hypothetical protein 0.0268 0.306 0.3056
Entamoeba histolytica cysteine protease, putative 0.0279 0.3196 0.3509
Giardia lamblia Cathepsin B precursor 0.0114 0.1086 0.0315
Brugia malayi Histone deacetylase family protein 0.06 0.731 0.731
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0403 0.0399
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0886 0.0877
Brugia malayi heat shock protein 90 0.011 0.1037 0.1037
Brugia malayi CHE-14 protein 0.0041 0.0163 0.0163
Echinococcus granulosus heat shock protein 90 0.0094 0.0832 0.0823
Echinococcus granulosus g protein coupled receptor 0.0067 0.0488 0.0479
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0114 0.1086 0.1056
Leishmania major heat shock protein 83-1 0.011 0.1037 0.1141
Giardia lamblia Cathepsin L precursor 0.0114 0.1086 0.0315
Echinococcus granulosus 7TM GPCR rhodopsin 0.0067 0.0488 0.0479
Echinococcus multilocularis g protein coupled receptor 0.0067 0.0488 0.0479
Trypanosoma brucei heat shock protein, putative 0.011 0.1037 0.1141
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0067 0.0488 0.0484
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0521 0.6289 0.7005
Giardia lamblia Cathepsin L precursor 0.0114 0.1086 0.0315
Echinococcus multilocularis serotonin receptor 0.0067 0.0488 0.0479
Echinococcus granulosus sex peptide receptor 0.0067 0.0488 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0114 0.1086 0.1056
Trypanosoma cruzi cysteine peptidase, putative 0.0279 0.3196 0.318
Echinococcus multilocularis integrin beta 2 0.0135 0.1365 0.1357
Entamoeba histolytica cysteine protease, putative 0.0114 0.1086 0.1113
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0488 0.0479
Plasmodium falciparum serine repeat antigen 7 0.0114 0.1086 0.1197
Echinococcus multilocularis G-protein coupled receptor, putative 0.0067 0.0488 0.0479
Giardia lamblia Encystation-specific protease 0.0114 0.1086 0.0315
Onchocerca volvulus 0.0067 0.0488 0.0777
Giardia lamblia Cathepsin B precursor 0.0114 0.1086 0.0315
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0067 0.0488 0.0479
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0098 0.0891 0.7052
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0094 0.0832 0.0823
Echinococcus granulosus neuropeptide receptor 0.0067 0.0488 0.0479
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0163 0.0158
Entamoeba histolytica cysteine protease, putative 0.0279 0.3196 0.3509
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0508 0.6132 0.6128
Schistosoma mansoni neuropeptide f receptor 76f 0.0067 0.0488 0.0479
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0488 0.0479
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0249 0.0239
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Schistosoma mansoni neuropeptide receptor 0.0067 0.0488 0.0479
Entamoeba histolytica cysteine protease, putative 0.0114 0.1086 0.1113
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0067 0.0488 0.0479
Loa Loa (eye worm) hypothetical protein 0.0041 0.0163 0.0158
Brugia malayi G protein-coupled receptor 0.0067 0.0488 0.0488
Giardia lamblia Cysteine protease 0.0114 0.1086 0.0315
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0067 0.0488 0.0479
Echinococcus granulosus geminin 0.0205 0.225 0.2242
Echinococcus multilocularis endoplasmin 0.0098 0.0891 0.0882
Brugia malayi hypothetical protein 0.0067 0.0488 0.0488
Brugia malayi ORL1-like opioid receptor 0.0067 0.0488 0.0488
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0067 0.0488 0.0777
Loa Loa (eye worm) hypothetical protein 0.0521 0.6289 0.6288
Trypanosoma cruzi heat shock protein 90, putative 0.0062 0.042 0.0398
Toxoplasma gondii histone deacetylase HDAC5 0.0352 0.4133 0.4633
Echinococcus multilocularis neuropeptide receptor A26 0.0067 0.0488 0.0479
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0067 0.0488 0.0479
Schistosoma mansoni lipoxygenase 0.0355 0.4176 0.4171
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0488 0.0479
Onchocerca volvulus 0.0067 0.0488 0.0777
Loa Loa (eye worm) hypothetical protein 0.0114 0.1086 0.1082
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Trypanosoma brucei histone deacetylase 1 0.0725 0.891 1
Plasmodium vivax histone deacetylase 1, putative 0.0725 0.891 1
Toxoplasma gondii histone deacetylase HDAC3 0.0725 0.891 1
Entamoeba histolytica cysteine protease, putative 0.0521 0.6289 0.7023
Onchocerca volvulus 0.0114 0.1086 0.1727
Echinococcus multilocularis neuropeptide Y receptor 0.0067 0.0488 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.6289 0.7005
Brugia malayi Papain family cysteine protease containing protein 0.0114 0.1086 0.1086
Toxoplasma gondii Hsp90 domain-containing protein 0.0053 0.0309 0.0336
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0053 0.0309 0.0299
Schistosoma mansoni amine GPCR 0.0067 0.0488 0.0479
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0053 0.0309 0.0299
Toxoplasma gondii heat shock protein HSP90 0.011 0.1037 0.1154
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0811 1 1
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0052 0.0301 0.028
Loa Loa (eye worm) hypothetical protein 0.0051 0.0282 0.0277
Brugia malayi hypothetical protein 0.0067 0.0488 0.0488
Leishmania major heat shock protein 83-1 0.011 0.1037 0.1141
Echinococcus granulosus neuropeptides capa receptor 0.0067 0.0488 0.0479
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0311 0.0302
Entamoeba histolytica cysteine protease, putative 0.0279 0.3196 0.3509
Loa Loa (eye worm) G-protein coupled receptor 0.0067 0.0488 0.0484
Trypanosoma cruzi cysteine peptidase, putative 0.0165 0.1742 0.1724
Loa Loa (eye worm) hypothetical protein 0.0352 0.4133 0.413
Onchocerca volvulus 0.0521 0.6289 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Trypanosoma cruzi heat shock protein, putative 0.0053 0.0309 0.0287
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0107 0.0097
Echinococcus granulosus 7tm_1 domain containing protein 0.0067 0.0488 0.0479
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0114 0.1086 0.1113
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Leishmania major heat shock protein 83-1 0.011 0.1037 0.1141
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0488 0.0479
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0067 0.0488 0.0479
Onchocerca volvulus 0.0067 0.0488 0.0777
Onchocerca volvulus 0.0067 0.0488 0.0777
Brugia malayi hypothetical protein 0.0067 0.0488 0.0488
Entamoeba histolytica hypothetical protein 0.0114 0.1086 0.1113
Loa Loa (eye worm) ctsf protein 0.0521 0.6289 0.6288
Echinococcus granulosus G protein coupled receptor 139 0.0067 0.0488 0.0479
Mycobacterium ulcerans heat shock protein 90 0.0098 0.0891 1
Schistosoma mansoni biogenic amine receptor 0.0067 0.0488 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.6289 0.7005
Brugia malayi prolyl oligopeptidase family protein 0.0131 0.1314 0.1314
Trichomonas vaginalis heat shock protein, putative 0.0094 0.0832 0.0765
Trypanosoma cruzi heat shock protein 85, putative 0.011 0.1037 0.1017
Trypanosoma brucei Fatty acid elongase 0.0034 0.0072 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0521 0.6289 0.7052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0521 0.6289 0.7052
Echinococcus granulosus biogenic amine 5HT receptor 0.0067 0.0488 0.0479
Giardia lamblia Cathepsin B precursor 0.0114 0.1086 0.0315
Trypanosoma cruzi cysteine peptidase, putative 0.0521 0.6289 0.6281
Loa Loa (eye worm) hypothetical protein 0.0165 0.1742 0.1739
Echinococcus granulosus histone deacetylase 6 0.062 0.756 0.7557
Loa Loa (eye worm) hypothetical protein 0.0085 0.072 0.0715
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Echinococcus multilocularis heat shock protein 90 0.0094 0.0832 0.0823
Brugia malayi Dopamine receptor protein 2 0.0067 0.0488 0.0488
Echinococcus granulosus cathepsin l1 0.0356 0.418 0.4174
Echinococcus granulosus g-protein coupled receptor 0.0067 0.0488 0.0479
Echinococcus granulosus endoplasmin 0.0098 0.0891 0.0882
Echinococcus granulosus tm gpcr rhodopsin 0.0067 0.0488 0.0479
Echinococcus multilocularis cathepsin L cysteine protease 0.0521 0.6289 0.6286
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0067 0.0488 0.0488
Trypanosoma brucei heat shock protein 90, putative 0.011 0.1037 0.1141
Leishmania major cathepsin L-like protease 0.0521 0.6289 0.7052
Plasmodium vivax vivapain-3 0.0279 0.3196 0.358
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0488 0.0479
Schistosoma mansoni endoplasmin 0.011 0.1037 0.1028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0114 0.1086 0.1056
Schistosoma mansoni endoplasmin 0.011 0.1037 0.1028
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0052 0.0301 0.0314
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0114 0.1086 0.1078
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0114 0.1086 0.121
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0867 0.0863
Brugia malayi putative neuropeptide receptor 0.0067 0.0488 0.0488
Onchocerca volvulus 0.0356 0.418 0.6646
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Schistosoma mansoni hypothetical protein 0.004 0.0143 0.0134
Brugia malayi Endoplasmin precursor 0.011 0.1037 0.1037
Echinococcus multilocularis geminin 0.0205 0.225 0.2242
Echinococcus granulosus histone deacetylase 8 0.0352 0.4133 0.4127
Leishmania major cathepsin L-like protease 0.0521 0.6289 0.7052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0521 0.6289 0.7052
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0114 0.1086 0.1056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0521 0.6289 0.7052
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0229 0.0219
Giardia lamblia Cysteine protease 0.0114 0.1086 0.0315
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Echinococcus multilocularis g protein coupled receptor 0.0067 0.0488 0.0479
Plasmodium falciparum serine repeat antigen 4 0.0114 0.1086 0.1197
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0229 0.0224
Giardia lamblia Cathepsin B precursor 0.0114 0.1086 0.0315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0114 0.1086 0.1056
Echinococcus multilocularis orexin receptor type 2 0.0067 0.0488 0.0479
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0053 0.0309 0.0229
Echinococcus granulosus peptide allatostatin:somatostatin 0.0067 0.0488 0.0479
Echinococcus granulosus histone deacetylase 6 0.06 0.731 0.7308
Brugia malayi neuropeptide F receptor 0.0067 0.0488 0.0488
Brugia malayi cathepsin L-like cysteine proteinase 0.0114 0.1086 0.1086
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0521 0.6289 0.7052
Loa Loa (eye worm) neuropeptide F receptor 0.0067 0.0488 0.0484
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0114 0.1086 0.1078
Giardia lamblia Cysteine protease 0.0114 0.1086 0.0315
Leishmania major histone deacetylase, putative 0.0725 0.891 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0311 0.0302
Brugia malayi TAR-binding protein 0.0062 0.0427 0.0427
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0114 0.1086 0.0315
Plasmodium vivax vivapain-1 0.0279 0.3196 0.358
Trypanosoma cruzi cysteine peptidase, putative 0.0521 0.6289 0.6281
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0809 0.9972 0.9972
Plasmodium falciparum heat shock protein 90 0.011 0.1037 0.1141
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0022 0.0014
Loa Loa (eye worm) hypothetical protein 0.0174 0.1863 0.1859
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0521 0.6289 0.6286
Entamoeba histolytica cysteine proteinase, putative 0.0279 0.3196 0.3509
Brugia malayi hypothetical protein 0.0067 0.0488 0.0488
Onchocerca volvulus 0.0048 0.0253 0.0402
Plasmodium falciparum histone deacetylase 1 0.0725 0.891 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Echinococcus multilocularis neuropeptides capa receptor 0.0067 0.0488 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.6289 0.7005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0403 0.0403
Echinococcus multilocularis neuropeptide receptor 0.0067 0.0488 0.0479
Leishmania major cathepsin L-like protease 0.0521 0.6289 0.7052
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0083
Trypanosoma cruzi heat shock protein 85, putative 0.011 0.1037 0.1017
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0114 0.1086 0.1056
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0114 0.1086 0.1056
Echinococcus multilocularis protein patched 0.0041 0.0163 0.0153
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Brugia malayi hypothetical protein 0.0067 0.0488 0.0488
Plasmodium vivax GNS1/SUR4 domain containing protein 0.0034 0.0072 0.007
Onchocerca volvulus Cathepsin L homolog 0.0114 0.1086 0.1727
Leishmania major heat shock protein 83-1 0.011 0.1037 0.1141
Onchocerca volvulus 0.0067 0.0488 0.0777
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0067 0.0488 0.0479
Brugia malayi Kelch motif family protein 0.0029 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0067 0.0488 0.0479
Onchocerca volvulus 0.0067 0.0488 0.0777
Schistosoma mansoni rab6-interacting 0.0085 0.072 0.0711
Echinococcus multilocularis Polycystic kidney disease protein 0.0085 0.072 0.0711
Loa Loa (eye worm) neuropeptide F receptor 0.0067 0.0488 0.0484
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0427 0.0423
Echinococcus granulosus histone deacetylase 1 0.0725 0.891 0.8909
Trypanosoma cruzi heat shock protein 85, putative 0.011 0.1037 0.1017
Brugia malayi fibroinase precursor 0.0114 0.1086 0.1086
Schistosoma mansoni neuropeptide F-like receptor 0.0067 0.0488 0.0479
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0067 0.0488 0.0488
Plasmodium falciparum endoplasmin, putative 0.0064 0.0454 0.0486
Echinococcus granulosus tumor protein p63 0.0331 0.3868 0.3862
Entamoeba histolytica cysteine proteinase 2 0.0279 0.3196 0.3509
Trypanosoma brucei heat shock protein 90, putative 0.011 0.1037 0.1141
Giardia lamblia Cathepsin L precursor 0.0114 0.1086 0.0315
Schistosoma mansoni neuropeptide receptor 0.0067 0.0488 0.0479
Onchocerca volvulus 0.0234 0.2621 0.4167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0488 0.0479
Loa Loa (eye worm) integrin beta-2 0.0185 0.1999 0.1995
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0114 0.1086 0.1082
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0279 0.3196 0.3189
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0114 0.1086 0.121
Trypanosoma brucei prolyl endopeptidase 0.0131 0.1314 0.1453
Brugia malayi Cathepsin L-like precursor 0.0165 0.1742 0.1742
Echinococcus multilocularis fmrfamide receptor 0.0067 0.0488 0.0479
Brugia malayi hypothetical protein 0.0067 0.0488 0.0488
Schistosoma mansoni histone deacetylase hda2 0.062 0.756 0.7557
Schistosoma mansoni integrin beta subunit 0.0106 0.0994 0.0985
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0229 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0521 0.6289 0.7005
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0488 0.0479
Schistosoma mansoni hypothetical protein 0.004 0.0143 0.0134
Echinococcus multilocularis g protein coupled receptor 0.0067 0.0488 0.0479
Loa Loa (eye worm) hypothetical protein 0.0047 0.0229 0.0224
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0067 0.0488 0.0479
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0427 0.0418
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0484
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0427 0.0418

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0168 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1458 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2311 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.4467 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 0.5012 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7667 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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