Detailed information for compound 150443

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 402.448 | Formula: C19H26N6O4
  • H donors: 4 H acceptors: 6 LogP: 0.17 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN(c1nc(NCc2ccc(cc2)OC)c2c(n1)n(CCO)cn2)CCO
  • InChi: 1S/C19H26N6O4/c1-29-15-4-2-14(3-5-15)12-20-17-16-18(25(8-11-28)13-21-16)23-19(22-17)24(6-9-26)7-10-27/h2-5,13,26-28H,6-12H2,1H3,(H,20,22,23)
  • InChiKey: OIGZVPTYAXYLOE-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin E2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus pyruvate kinase 0.0018 0.0057 0.0013
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0117 0.0802 0.0792
Echinococcus granulosus calpain A 0.0041 0.0229 0.0186
Schistosoma mansoni neuropeptide receptor 0.0017 0.0044 0.0032
Echinococcus granulosus pyruvate kinase 0.0018 0.0057 0.0013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0272 0.0229
Entamoeba histolytica cysteine protease, putative 0.0321 0.2339 0.5359
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0.0044 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0685 0.5077 1
Leishmania major cathepsin L-like protease 0.0589 0.4354 0.8573
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0407 0.0396
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0123 0.0843 0.0843
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0044 0.0032
Brugia malayi RE15519p 0.0017 0.0044 0.0044
Echinococcus granulosus cathepsin b 0.1338 1 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0703 0.0692
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0139 0.0965 0.2113
Schistosoma mansoni biogenic amine receptor 0.0017 0.0044 0.0032
Schistosoma mansoni biogenic amine receptor 0.0017 0.0044 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0589 0.4354 1
Entamoeba histolytica cysteine protease, putative 0.0139 0.0965 0.2195
Onchocerca volvulus Peroxidase homolog 0.0104 0.0703 0.1529
Giardia lamblia Cathepsin B precursor 0.0139 0.0965 0.2452
Onchocerca volvulus 0.0021 0.008 0.0083
Toxoplasma gondii hypothetical protein 0.0016 0.0041 0.0067
Brugia malayi hypothetical protein 0.0104 0.0703 0.0703
Chlamydia trachomatis pyruvate kinase 0.0036 0.0188 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0589 0.4354 0.4348
Brugia malayi Dopamine receptor protein 1 0.0017 0.0044 0.0044
Brugia malayi hypothetical protein 0.0017 0.0044 0.0044
Giardia lamblia Cathepsin B precursor 0.0139 0.0965 0.2452
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0062 0.0388 0.0388
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0789 0.0778
Brugia malayi Papain family cysteine protease containing protein 0.0139 0.0965 0.0965
Schistosoma mansoni amine GPCR 0.0017 0.0044 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0321 0.2339 0.5359
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1338 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0272 0.0272
Trichomonas vaginalis cyclin B, putative 0.0021 0.008 0.0157
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Schistosoma mansoni hypothetical protein 0.0017 0.0044 0.0032
Brugia malayi MH2 domain containing protein 0.0116 0.0789 0.0789
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0321 0.2339 0.4594
Echinococcus granulosus geminin 0.0182 0.129 0.1251
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.1705 0.1668
Brugia malayi calpain D 0.0012 0.0012 0.0012
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0139 0.0965 0.0954
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0139 0.0965 0.2452
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0044 0.0032
Brugia malayi Animal haem peroxidase family protein 0.0107 0.0725 0.0725
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Plasmodium falciparum cysteine proteinase falcipain 1 0.0321 0.2339 0.5359
Echinococcus multilocularis calpain family protein 1, d 0.008 0.0524 0.0482
Brugia malayi Cathepsin L-like precursor 0.0589 0.4354 0.4354
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0502 0.3703 0.3696
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0139 0.0965 0.2113
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0044 0.0032
Brugia malayi calpain family protein 1 0.0109 0.0741 0.0741
Schistosoma mansoni biogenic amine receptor 0.0017 0.0044 0.0032
Toxoplasma gondii preprocathepsin c precursor, putative 0.0139 0.0965 0.2195
Loa Loa (eye worm) hypothetical protein 0.1338 1 1
Entamoeba histolytica cysteine protease, putative 0.0321 0.2339 0.5359
Giardia lamblia Cathepsin L precursor 0.0139 0.0965 0.2452
Trichomonas vaginalis cyclins, putative 0.0021 0.008 0.0157
Brugia malayi Cathepsin L-like precursor 0.0589 0.4354 0.4354
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0188 0.0177
Giardia lamblia Hypothetical protein 0.0139 0.0965 0.2452
Onchocerca volvulus Peroxidasin homolog 0.0107 0.0725 0.158
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0017 0.0044 0.0032
Giardia lamblia Cathepsin L precursor 0.0139 0.0965 0.2452
Plasmodium vivax serine-repeat antigen (SERA) 0.0139 0.0965 0.2113
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.051 0.3759 0.3752
Brugia malayi calpain 5 0.0029 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0.0044 0.0044
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0107 0.0095
Trichomonas vaginalis cyclin D, putative 0.0021 0.008 0.0157
Entamoeba histolytica cysteine protease, putative 0.0321 0.2339 0.5359
Echinococcus granulosus myosin light chain kinase smooth muscle 0.0242 0.1742 0.1706
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.051 0.3759 0.3752
Loa Loa (eye worm) blistered cuticle protein 3 0.0104 0.0703 0.0692
Onchocerca volvulus 0.0139 0.0965 0.2136
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0229 0.0217
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0139 0.0965 0.2195
Trypanosoma cruzi cyclin, putative 0.0021 0.008 0.0068
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0139 0.0965 0.0954
Loa Loa (eye worm) animal heme peroxidase 0.0104 0.0703 0.0692
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0139 0.0965 0.2113
Toxoplasma gondii cathepsin B 0.051 0.3759 0.863
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0139 0.0965 0.2195
Brugia malayi hypothetical protein 0.0237 0.1705 0.1705
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0188 0.0407
Brugia malayi cathepsin L precursor 0.0139 0.0965 0.0965
Trypanosoma cruzi cysteine peptidase, putative 0.0685 0.5077 0.5071
Schistosoma mansoni cyclin B 0.0021 0.008 0.0068
Echinococcus granulosus cathepsin L cysteine protease 0.0321 0.2339 0.2305
Loa Loa (eye worm) hypothetical protein 0.0139 0.0965 0.0954
Loa Loa (eye worm) hypothetical protein 0.0107 0.0725 0.0714
Trypanosoma cruzi kinesin, putative 0.0029 0.0135 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0685 0.5077 1
Loa Loa (eye worm) hypothetical protein 0.0406 0.298 0.2972
Loa Loa (eye worm) cyclin domain-containing protein 0.0021 0.008 0.0068
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0.0044 0.0044
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0044 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0044 0.0032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Leishmania major cathepsin L-like protease 0.0685 0.5077 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0017 0.0044 0.0032
Entamoeba histolytica cysteine proteinase, putative 0.0321 0.2339 0.5359
Entamoeba histolytica hypothetical protein 0.0139 0.0965 0.2195
Trypanosoma cruzi cysteine proteinase, putative 0.0321 0.2339 0.233
Loa Loa (eye worm) animal heme peroxidase 0.0107 0.0725 0.0714
Plasmodium vivax vivapain-1 0.0321 0.2339 0.531
Giardia lamblia Cathepsin B precursor 0.0139 0.0965 0.2452
Trypanosoma brucei kinesin, putative 0.0029 0.0135 0.0244
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.006 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0017 0.0044 0.0032
Echinococcus multilocularis serine:threonine protein kinase 0.0242 0.1742 0.1706
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Echinococcus multilocularis calpain 7 (C02 family) 0.0041 0.0229 0.0186
Giardia lamblia Cathepsin L precursor 0.0139 0.0965 0.2452
Brugia malayi putative neuropeptide receptor 0.0017 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.008 0.0157
Loa Loa (eye worm) calpain family protein 1 0.0109 0.0741 0.073
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1338 1 1
Schistosoma mansoni amine GPCR 0.0017 0.0044 0.0032
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0139 0.0965 0.0954
Loa Loa (eye worm) hypothetical protein 0.0021 0.008 0.0068
Echinococcus multilocularis cathepsin b 0.1338 1 1
Schistosoma mansoni cathepsin B (C01 family) 0.0139 0.0965 0.0954
Schistosoma mansoni neuropeptide receptor 0.0017 0.0044 0.0032
Schistosoma mansoni opsin-like receptor 0.0017 0.0044 0.0032
Plasmodium falciparum cysteine proteinase falcipain 3 0.0589 0.4354 1
Trypanosoma brucei calpain-like protein, putative 0.0041 0.0229 0.0428
Echinococcus multilocularis cyclins 0.0021 0.008 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0685 0.5077 1
Brugia malayi Cathepsin L-like precursor 0.0589 0.4354 0.4354
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0188 0.0177
Brugia malayi cathepsin L-like precursor 0.0406 0.298 0.298
Entamoeba histolytica cysteine protease, putative 0.0321 0.2339 0.5359
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0044 0.0032
Schistosoma mansoni Mername-AA248 (C02 family) 0.0041 0.0229 0.0217
Brugia malayi AKH receptor 0.0017 0.0044 0.0044
Echinococcus multilocularis cathepsin L 0.0139 0.0965 0.0925
Loa Loa (eye worm) hypothetical protein 0.0104 0.0703 0.0692
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Entamoeba histolytica cysteine protease, putative 0.0139 0.0965 0.2195
Giardia lamblia Cysteine protease 0.0139 0.0965 0.2452
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Loa Loa (eye worm) hypothetical protein 0.0139 0.0965 0.0954
Loa Loa (eye worm) hypothetical protein 0.0139 0.0965 0.0954
Entamoeba histolytica cysteine protease, putative 0.0321 0.2339 0.5359
Leishmania major cathepsin L-like protease 0.0589 0.4354 0.8573
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0589 0.4354 0.4348
Echinococcus granulosus cathepsin L cysteine proteinase 0.0589 0.4354 0.4329
Schistosoma mansoni cathepsin F (C01 family) 0.0589 0.4354 0.4348
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Schistosoma mansoni hypothetical protein 0.0017 0.0044 0.0032
Loa Loa (eye worm) ctsf protein 0.0589 0.4354 0.4348
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0589 0.4354 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Entamoeba histolytica cysteine protease, putative 0.0589 0.4354 1
Schistosoma mansoni hypothetical protein 0.0182 0.129 0.128
Trichomonas vaginalis conserved hypothetical protein 0.0139 0.0965 0.2195
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0139 0.0965 0.2113
Echinococcus multilocularis cyclin B3 1 0.0021 0.008 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0589 0.4354 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0703 0.0692
Plasmodium falciparum serine repeat antigen 8 0.0139 0.0965 0.2195
Trichomonas vaginalis cyclins, putative 0.0021 0.008 0.0157
Onchocerca volvulus Dual oxidase homolog 0.0104 0.0703 0.1529
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0139 0.0965 0.2195
Giardia lamblia Encystation-specific protease 0.0139 0.0965 0.2452
Entamoeba histolytica cyclin, putative 0.0021 0.008 0.0157
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0017 0.0044 0.0032
Schistosoma mansoni cathepsin F (C01 family) 0.0406 0.298 0.2972
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0407 0.0396
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0188 0.5
Plasmodium falciparum serine repeat antigen 3 0.0139 0.0965 0.2195
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0139 0.0965 0.2195
Entamoeba histolytica cysteine protease, putative 0.0139 0.0965 0.2195
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Loa Loa (eye worm) hypothetical protein 0.0104 0.0703 0.0692
Giardia lamblia Hypothetical protein 0.0139 0.0965 0.2452
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0188 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0139 0.0965 0.2195
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0272 0.0261
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0057 0.0104
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0017 0.0044 0.0032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.051 0.3759 0.863
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0188 0.5
Plasmodium vivax vivapain-2 0.0589 0.4354 1
Brugia malayi G-protein coupled receptor 0.0017 0.0044 0.0044
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0139 0.0965 0.0954
Onchocerca volvulus 0.0048 0.0283 0.0554
Schistosoma mansoni cathepsin C 0.0139 0.0965 0.0954
Entamoeba histolytica cysteine protease, putative 0.0139 0.0965 0.2195
Schistosoma mansoni histamine h1 receptor 0.0017 0.0044 0.0032
Brugia malayi Animal haem peroxidase family protein 0.0104 0.0703 0.0703
Echinococcus multilocularis calpain 5 0.0041 0.0229 0.0186
Trichomonas vaginalis cyclins, putative 0.0021 0.008 0.0157
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0017 0.0044 0.0032
Brugia malayi Peroxidasin 0.0107 0.0725 0.0725
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0789 0.0778
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0041 0.0229 0.0217
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Entamoeba histolytica cysteine proteinase, putative 0.0321 0.2339 0.5359
Schistosoma mansoni calpain (C02 family) 0.0041 0.0229 0.0217
Brugia malayi Cathepsin L-like precursor 0.0589 0.4354 0.4354
Schistosoma mansoni hypothetical protein 0.0017 0.0044 0.0032
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0021 0.008 0.0135
Echinococcus multilocularis cyclins 0.0021 0.008 0.0036
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0044 0.0032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Trichomonas vaginalis cyclin B3, putative 0.0021 0.008 0.0157
Loa Loa (eye worm) hypothetical protein 0.0097 0.0648 0.0637
Entamoeba histolytica cysteine protease, putative 0.0321 0.2339 0.5359
Brugia malayi RNA binding protein 0.0065 0.0407 0.0407
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0589 0.4354 1
Brugia malayi GnHR receptor homolog 0.0017 0.0044 0.0044
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0104 0.0703 0.0692
Echinococcus granulosus peroxidasin 0.0107 0.0725 0.0684
Schistosoma mansoni calpain C (C02 family) 0.0041 0.0229 0.0217
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0044 0.0032
Entamoeba histolytica cyclin family protein 0.0021 0.008 0.0157
Brugia malayi Animal haem peroxidase family protein 0.0104 0.0703 0.0703
Trypanosoma brucei cysteine peptidase C (CPC) 0.051 0.3759 0.7398
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0017 0.0044 0.0032
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0589 0.4354 1
Schistosoma mansoni neuropeptide receptor 0.0017 0.0044 0.0032
Giardia lamblia Cathepsin L precursor 0.0139 0.0965 0.2452
Loa Loa (eye worm) hypothetical protein 0.0406 0.298 0.2972
Giardia lamblia Cathepsin L-like protease 0.0139 0.0965 0.2452
Schistosoma mansoni calpain-7 (C02 family) 0.0041 0.0229 0.0217
Echinococcus granulosus microtubule associated protein 2 0.0742 0.5504 0.5484
Leishmania major cathepsin L-like protease 0.0589 0.4354 0.8573
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0139 0.0965 0.2195
Brugia malayi Blistered cuticle protein 3 0.0104 0.0703 0.0703
Loa Loa (eye worm) hypothetical protein 0.0123 0.0843 0.0833
Trypanosoma cruzi cruzipain precursor, putative 0.0685 0.5077 0.5071
Brugia malayi Papain family cysteine protease containing protein 0.0139 0.0965 0.0965
Echinococcus granulosus pyruvate kinase 0.0036 0.0188 0.0145
Loa Loa (eye worm) hypothetical protein 0.0036 0.0188 0.0177
Brugia malayi calpain 5 0.0012 0.0012 0.0012
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.0965 0.0954
Entamoeba histolytica cysteine protease, putative 0.0321 0.2339 0.5359
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0188 0.0177
Echinococcus granulosus cysteine protease 0.0321 0.2339 0.2305
Brugia malayi larval opioid receptor 0.0017 0.0044 0.0044
Entamoeba histolytica cyclin family protein 0.0021 0.008 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0321 0.2339 0.5359
Schistosoma mansoni dopamine-beta-monooxygenase 0.0123 0.0843 0.0833
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0321 0.2339 0.233
Entamoeba histolytica cysteine proteinase 2 0.0321 0.2339 0.5359
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0182 0.1292 0.1292
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0139 0.0965 0.2195
Echinococcus multilocularis hypothetical protein 0.0041 0.0229 0.0186
Trichomonas vaginalis cyclin B, putative 0.0021 0.008 0.0157
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0231 0.166 0.166
Loa Loa (eye worm) calpain 5 0.0029 0.0135 0.0124
Loa Loa (eye worm) hypothetical protein 0.0104 0.0703 0.0692
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0272 0.0229
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0229 0.0217
Leishmania major cyclin 0.0021 0.008 0.0135
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.0965 0.0954
Giardia lamblia Cathepsin B precursor 0.051 0.3759 1
Brugia malayi Dopamine receptor 0.0017 0.0044 0.0044
Entamoeba histolytica calpain large subunit domain III containing protein 0.0029 0.0135 0.0285
Brugia malayi follicle stimulating hormone receptor 0.0017 0.0044 0.0044
Echinococcus granulosus cathepsin L 0.0321 0.2339 0.2305
Onchocerca volvulus Chorion peroxidase homolog 0.0104 0.0703 0.1529
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0017 0.0044 0.0032
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0017 0.0044 0.0032
Leishmania major pyruvate kinase 0.0036 0.0188 0.0349
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0231 0.166 0.1623
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0107 0.0219
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0021 0.008 0.0036
Plasmodium falciparum cyclin 0.0021 0.008 0.0157
Brugia malayi Cathepsin L-like precursor 0.0589 0.4354 0.4354
Leishmania major cathepsin L-like protease 0.0589 0.4354 0.8573
Giardia lamblia Cathepsin L-like protease 0.0139 0.0965 0.2452
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0117 0.0802 0.0762
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Onchocerca volvulus 0.0406 0.298 0.6812
Entamoeba histolytica cysteine proteinase, putative 0.0321 0.2339 0.5359
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0229 0.0217
Echinococcus multilocularis cathepsin b 0.1338 1 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0229 0.0217
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Onchocerca volvulus 0.0589 0.4354 1
Echinococcus granulosus tar DNA binding protein 0.0065 0.0407 0.0365
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0139 0.0965 0.2113
Brugia malayi hypothetical protein 0.0017 0.0044 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0685 0.5077 1
Toxoplasma gondii cathepsin CPL 0.0589 0.4354 1
Onchocerca volvulus Cathepsin F homolog 0.0589 0.4354 1
Brugia malayi G-protein coupled receptor 0.0017 0.0044 0.0044
Brugia malayi hypothetical protein 0.0017 0.0044 0.0044
Loa Loa (eye worm) animal heme peroxidase 0.0104 0.0703 0.0692
Echinococcus granulosus calpain 7 C02 family 0.0041 0.0229 0.0186
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0044 0.0032
Loa Loa (eye worm) hypothetical protein 0.0021 0.008 0.0068
Entamoeba histolytica cysteine protease, putative 0.0321 0.2339 0.5359
Toxoplasma gondii cathepsin CPC2 0.0139 0.0965 0.2195
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0182 0.1292 0.1282
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0017 0.0044 0.0032
Loa Loa (eye worm) hypothetical protein 0.0139 0.0965 0.0954
Echinococcus granulosus cyclin b3 0.0021 0.008 0.0036
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0188 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.0965 0.2195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0044 0.0032
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0117 0.0802 0.0762
Loa Loa (eye worm) hypothetical protein 0.0104 0.0703 0.0692
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0044 0.0032
Trichomonas vaginalis cyclins, putative 0.0021 0.008 0.0157
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0.0044 0.0044
Brugia malayi sulfakinin receptor protein 0.0017 0.0044 0.0044
Echinococcus multilocularis myosin light chain kinase, smooth muscle 0.0242 0.1742 0.1706
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0139 0.0965 0.0954
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0685 0.5077 1
Giardia lamblia Cyclin A 0.0021 0.008 0.0062
Brugia malayi cathepsin L-like cysteine proteinase 0.0139 0.0965 0.0965
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0044 0.0032
Schistosoma mansoni cathepsin s 0.0182 0.1292 0.1282
Echinococcus multilocularis geminin 0.0182 0.129 0.1251
Schistosoma mansoni neuropeptide receptor 0.0017 0.0044 0.0032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Schistosoma mansoni amine GPCR 0.0017 0.0044 0.0032
Echinococcus multilocularis cathepsin L 0.0321 0.2339 0.2305
Echinococcus multilocularis pyruvate kinase 0.0018 0.0057 0.0013
Loa Loa (eye worm) fibroinase 0.0589 0.4354 0.4348
Schistosoma mansoni peroxidasin 0.0104 0.0703 0.0692
Schistosoma mansoni amine GPCR 0.0017 0.0044 0.0032
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0188 0.0349
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Echinococcus multilocularis peroxidasin 0.0107 0.0725 0.0684
Echinococcus granulosus calpain 0.0041 0.0229 0.0186
Plasmodium falciparum serine repeat antigen 7 0.0139 0.0965 0.2195
Trypanosoma brucei mitotic cyclin 6 0.0021 0.008 0.0135
Giardia lamblia Pyruvate kinase 0.0036 0.0188 0.0355
Echinococcus multilocularis calpain 0.0041 0.0229 0.0186
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0095
Schistosoma mansoni pyruvate kinase 0.0036 0.0188 0.0177
Loa Loa (eye worm) hypothetical protein 0.0104 0.0703 0.0692
Schistosoma mansoni opsin-like receptor 0.0017 0.0044 0.0032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0044 0.0032
Plasmodium falciparum serine repeat antigen 2 0.0139 0.0965 0.2195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0044 0.0032
Schistosoma mansoni hypothetical protein 0.0048 0.0283 0.0271
Schistosoma mansoni adenoreceptor 0.0017 0.0044 0.0032
Onchocerca volvulus 0.0104 0.0703 0.1529
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0139 0.0965 0.2195
Giardia lamblia Cysteine protease 0.0139 0.0965 0.2452
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0109 0.0741 0.073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0044 0.0032
Onchocerca volvulus 0.0589 0.4354 1
Onchocerca volvulus Peroxidasin homolog 0.0107 0.0725 0.158
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0044 0.0032
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0057 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.0965 0.2195
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0017 0.0044 0.0032
Loa Loa (eye worm) hypothetical protein 0.0589 0.4354 0.4348
Echinococcus granulosus calpain 5 0.0041 0.0229 0.0186
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0229 0.0217
Plasmodium falciparum pyruvate kinase 0.0036 0.0188 0.0407
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0117 0.0802 0.0792
Brugia malayi Melatonin receptor type 1A 0.0017 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0589 0.4354 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0139 0.0965 0.0954
Schistosoma mansoni hypothetical protein 0.0182 0.129 0.128
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0229 0.0217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0685 0.5077 1
Trichomonas vaginalis conserved hypothetical protein 0.0139 0.0965 0.2195
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Plasmodium falciparum serine repeat antigen 4 0.0139 0.0965 0.2195
Brugia malayi Papain family cysteine protease containing protein 0.0321 0.2339 0.2339
Entamoeba histolytica cysteine protease, putative 0.0321 0.2339 0.5359
Entamoeba histolytica cyclin, putative 0.0021 0.008 0.0157
Echinococcus multilocularis pyruvate kinase 0.0018 0.0057 0.0013
Brugia malayi hypothetical protein 0.0017 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0589 0.4354 1
Onchocerca volvulus Cathepsin L homolog 0.0589 0.4354 1
Toxoplasma gondii cathepsin CPC1 0.0139 0.0965 0.2195
Trypanosoma cruzi cysteine proteinase, putative 0.0321 0.2339 0.233
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0589 0.4354 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0139 0.0965 0.0965
Loa Loa (eye worm) animal heme peroxidase 0.0104 0.0703 0.0692
Echinococcus granulosus cyclins 0.0021 0.008 0.0036
Giardia lamblia Cathepsin B precursor 0.0139 0.0965 0.2452
Echinococcus granulosus cyclins 0.0021 0.008 0.0036
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1338 1 1
Echinococcus multilocularis cyclins 0.0021 0.008 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0589 0.4354 1
Schistosoma mansoni pyruvate kinase 0.0018 0.0057 0.0045
Trypanosoma cruzi cysteine peptidase, putative 0.0685 0.5077 0.5071
Trichomonas vaginalis cyclin B, putative 0.0021 0.008 0.0157
Schistosoma mansoni alpha-1 adrenergic receptor 0.0017 0.0044 0.0032
Giardia lamblia Cathepsin B precursor 0.0139 0.0965 0.2452
Plasmodium vivax unspecified product 0.0139 0.0965 0.2113
Schistosoma mansoni hypothetical protein 0.0017 0.0044 0.0032
Schistosoma mansoni cyclin B3 0.0021 0.008 0.0068
Echinococcus granulosus cyclins 0.0021 0.008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Echinococcus granulosus serine:threonine protein kinase 0.0242 0.1742 0.1706
Trypanosoma cruzi cysteine peptidase, putative 0.0321 0.2339 0.233
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0589 0.4354 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0272 0.0229
Plasmodium vivax calpain, putative 0.0041 0.0229 0.04
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1338 1 1
Trypanosoma cruzi cyclin 6, putative 0.0021 0.008 0.0068
Plasmodium falciparum serine repeat antigen 1 0.0139 0.0965 0.2195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0589 0.4354 1
Schistosoma mansoni cathepsin F (C01 family) 0.0589 0.4354 0.4348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.0965 0.2195
Echinococcus multilocularis cyclins 0.0021 0.008 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.0965 0.2195
Entamoeba histolytica cysteine proteinase, putative 0.0589 0.4354 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0589 0.4354 0.4329
Entamoeba histolytica cysteine protease, putative 0.0321 0.2339 0.5359
Entamoeba histolytica cysteine proteinase, putative 0.0589 0.4354 1
Loa Loa (eye worm) calpain 0.0041 0.0229 0.0217
Onchocerca volvulus 0.0589 0.4354 1
Entamoeba histolytica cysteine protease, putative 0.0321 0.2339 0.5359
Brugia malayi Cyclin, N-terminal domain containing protein 0.0021 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0139 0.0965 0.2195
Loa Loa (eye worm) hypothetical protein 0.008 0.0524 0.0513
Brugia malayi Cathepsin L-like precursor 0.0406 0.298 0.298
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0589 0.4354 1
Trypanosoma cruzi cysteine peptidase, putative 0.0685 0.5077 0.5071
Trypanosoma cruzi CYC2-like cyclin, putative 0.0021 0.008 0.0068
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0.0044 0.0044
Giardia lamblia Cysteine protease 0.0139 0.0965 0.2452
Trypanosoma cruzi major cysteine proteinase, putative 0.0139 0.0965 0.0954
Echinococcus multilocularis calpain A 0.0118 0.0804 0.0763
Brugia malayi neuropeptide F receptor 0.0017 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0589 0.4354 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0965 0.0954
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0589 0.4354 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0017 0.0044 0.0032
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0321 0.2339 0.233
Echinococcus multilocularis cyclin b3 0.0021 0.008 0.0036
Echinococcus multilocularis pyruvate kinase 0.0036 0.0188 0.0145
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0407 0.0396
Brugia malayi hypothetical protein 0.0017 0.0044 0.0044
Plasmodium vivax vivapain-2 0.0589 0.4354 1
Echinococcus granulosus cyclins 0.0021 0.008 0.0036
Onchocerca volvulus 0.0589 0.4354 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.0965 0.2195
Echinococcus multilocularis microtubule associated protein 2 0.0742 0.5504 0.5484
Leishmania major cysteine peptidase A (CPA) 0.0589 0.4354 0.8573
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0407 0.0396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0589 0.4354 1
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0229 0.0428
Trichomonas vaginalis cyclin B, putative 0.0021 0.008 0.0157
Trichomonas vaginalis cyclin D, putative 0.0021 0.008 0.0157
Onchocerca volvulus 0.0589 0.4354 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0139 0.0965 0.2195
Brugia malayi fibroinase precursor 0.0139 0.0965 0.0965
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0229 0.0217
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0188 0.0335
Loa Loa (eye worm) TYRA-2 protein 0.0017 0.0044 0.0032
Loa Loa (eye worm) hypothetical protein 0.0182 0.1292 0.1282
Entamoeba histolytica cysteine protease, putative 0.0321 0.2339 0.5359
Echinococcus multilocularis cyclins 0.0021 0.008 0.0036
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0188 0.0335
Trypanosoma cruzi kinesin, putative 0.0029 0.0135 0.0124
Brugia malayi TAR-binding protein 0.0065 0.0407 0.0407
Entamoeba histolytica cysteine protease, putative 0.0321 0.2339 0.5359
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0139 0.0965 0.2113
Brugia malayi cathepsin Z-like cysteine proteinase 0.0139 0.0965 0.0965
Brugia malayi Serotonin receptor 0.0017 0.0044 0.0044
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0229 0.0428
Loa Loa (eye worm) hypothetical protein 0.0406 0.298 0.2972
Trypanosoma cruzi cysteine protease, putative 0.0321 0.2339 0.233
Loa Loa (eye worm) melatonin receptor type 1A 0.0017 0.0044 0.0032
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.1705 0.1668
Echinococcus granulosus pyruvate kinase 0.0036 0.0188 0.0145
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0407 0.0396
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0044 0.0032
Brugia malayi hypothetical protein 0.0017 0.0044 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0044 0.0032
Onchocerca volvulus 0.0589 0.4354 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0589 0.4354 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0044 0.0032
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0188 0.0306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0589 0.4354 1
Echinococcus multilocularis cyclins 0.0021 0.008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Schistosoma mansoni amine GPCR 0.0017 0.0044 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0589 0.4354 1
Echinococcus granulosus cyclins 0.0021 0.008 0.0036
Plasmodium falciparum serine repeat antigen 9 0.0139 0.0965 0.2195
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0231 0.166 0.1623
Echinococcus multilocularis cyclins 0.0021 0.008 0.0036
Giardia lamblia Cathepsin B precursor 0.051 0.3759 1
Echinococcus granulosus cathepsin l1 0.0589 0.4354 0.4329
Trypanosoma cruzi cruzipain precursor, putative 0.0182 0.1292 0.1282
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0407 0.0365
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0017 0.0044 0.0032
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0188 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0321 0.2339 0.5359
Brugia malayi neuropeptide F receptor 0.0017 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0109 0.0741 0.073
Leishmania major kinesin, putative 0.0029 0.0135 0.0244
Loa Loa (eye worm) hypothetical protein 0.0104 0.0703 0.0692
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0589 0.4354 1
Brugia malayi G protein-coupled receptor 0.0017 0.0044 0.0044
Onchocerca volvulus Cathepsin L homolog 0.0139 0.0965 0.2136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.0965 0.2195
Brugia malayi Cathepsin L-like precursor 0.0182 0.1292 0.1292
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0589 0.4354 0.4329
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0044 0.0032
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0589 0.4354 1
Trichomonas vaginalis cyclin B, putative 0.0021 0.008 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0589 0.4354 1
Giardia lamblia Cysteine protease 0.0139 0.0965 0.2452
Trichomonas vaginalis cyclin A, putative 0.0021 0.008 0.0157
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0685 0.5077 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0235 0.1688 0.1678
Plasmodium falciparum serine repeat antigen 6 0.0139 0.0965 0.2195
Echinococcus multilocularis pyruvate kinase 0.0036 0.0188 0.0145
Brugia malayi Animal haem peroxidase family protein 0.0104 0.0703 0.0703
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0139 0.0965 0.0954
Brugia malayi calpain 7 0.0041 0.0229 0.0229
Entamoeba histolytica cysteine proteinase, putative 0.0406 0.298 0.6836
Plasmodium vivax serine-repeat antigen (SERA) 0.0139 0.0965 0.2113
Brugia malayi Serotonin receptor 0.0017 0.0044 0.0044
Onchocerca volvulus Cathepsin L homolog 0.0589 0.4354 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0965 0.0954
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0139 0.0965 0.2452
Echinococcus multilocularis cysteine protease 0.0589 0.4354 0.4329
Onchocerca volvulus 0.0104 0.0703 0.1529
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Trypanosoma cruzi cysteine peptidase, putative 0.0182 0.1292 0.1282
Echinococcus granulosus cyclin B 0.0021 0.008 0.0036
Trypanosoma cruzi cyclin, putative 0.0021 0.008 0.0068
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0589 0.4354 0.4348
Brugia malayi ORL1-like opioid receptor 0.0017 0.0044 0.0044
Brugia malayi Papain family cysteine protease containing protein 0.0321 0.2339 0.2339
Echinococcus granulosus calpain A 0.0118 0.0804 0.0763
Plasmodium falciparum serine repeat antigen 5 0.0139 0.0965 0.2195
Loa Loa (eye worm) calpain family protein 1 0.008 0.0524 0.0513
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.051 0.3759 0.7398
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0229 0.0428
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0229 0.0217
Echinococcus granulosus cathepsin l cysteine peptidase 0.0589 0.4354 0.4329
Brugia malayi cathepsin F-like cysteine proteinase 0.0182 0.1292 0.1292
Loa Loa (eye worm) hypothetical protein 0.0182 0.1292 0.1282
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0139 0.0965 0.2113
Schistosoma mansoni pyruvate kinase 0.0036 0.0188 0.0177
Brugia malayi cathepsin Z-like cysteine proteinase 0.0139 0.0965 0.0965
Giardia lamblia G2/mitotic-specific cyclin B 0.0021 0.008 0.0062
Brugia malayi calpain family protein 1 0.0109 0.0741 0.0741
Brugia malayi hypothetical protein 0.0017 0.0044 0.0044
Brugia malayi Cyclin, N-terminal domain containing protein 0.0021 0.008 0.008
Onchocerca volvulus 0.0104 0.0703 0.1529
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1338 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0589 0.4354 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0283 0.0283
Brugia malayi Cyclin, N-terminal domain containing protein 0.0021 0.008 0.008
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0139 0.0965 0.2452
Trichomonas vaginalis cyclins, putative 0.0021 0.008 0.0157
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0139 0.0965 0.2195
Loa Loa (eye worm) hypothetical protein 0.0068 0.0431 0.042
Plasmodium vivax vivapain-3 0.0321 0.2339 0.531
Schistosoma mansoni opsin-like receptor 0.0017 0.0044 0.0032
Onchocerca volvulus 0.0068 0.0431 0.0897
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0272 0.0229
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0139 0.0965 0.2195
Giardia lamblia Hypothetical protein 0.0021 0.008 0.0062
Echinococcus multilocularis cathepsin L cysteine protease 0.0589 0.4354 0.4329
Loa Loa (eye worm) cysteine protease 0.0589 0.4354 0.4348
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0044 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0685 0.5077 1
Brugia malayi hypothetical protein 0.0017 0.0044 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0272 0.0261
Schistosoma mansoni peroxidasin 0.0104 0.0703 0.0692
Trypanosoma brucei calpain-like protein, putative 0.0041 0.0229 0.0428
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0321 0.2339 0.233
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0139 0.0965 0.2195
Onchocerca volvulus Peroxidase homolog 0.0104 0.0703 0.1529
Schistosoma mansoni survival motor neuron protein 0.0048 0.0283 0.0271
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0407 0.0407
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0139 0.0965 0.2113
Loa Loa (eye worm) hypothetical protein 0.0104 0.0703 0.0692
Loa Loa (eye worm) hypothetical protein 0.0237 0.1705 0.1695
Echinococcus granulosus pyruvate kinase 0.0018 0.0057 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0407 0.0396
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0229 0.0217
Echinococcus multilocularis pyruvate kinase 0.0028 0.0131 0.0088
Trypanosoma brucei antigen, putative 0.0041 0.0229 0.0428
Loa Loa (eye worm) cathepsin B 0.051 0.3759 0.3752
Onchocerca volvulus 0.0589 0.4354 1
Brugia malayi Animal haem peroxidase family protein 0.0104 0.0703 0.0703
Schistosoma mansoni microtubule-associated protein tau 0.0742 0.5504 0.5499
Brugia malayi Cathepsin L-like precursor 0.0406 0.298 0.298
Brugia malayi Papain family cysteine protease containing protein 0.0139 0.0965 0.0965
Entamoeba histolytica protein kinase, putative 0.0029 0.0137 0.0289
Plasmodium vivax unspecified product 0.0182 0.1292 0.2875
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0017 0.0044 0.0032
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0589 0.4354 0.4329
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0139 0.0965 0.2452
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0041 0.0229 0.0428
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0139 0.0965 0.0965
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0188 0.0335
Entamoeba histolytica cysteine protease, putative 0.0139 0.0965 0.2195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0589 0.4354 1
Echinococcus multilocularis pyruvate kinase 0.0018 0.0057 0.0013
Echinococcus granulosus cyclin B3 1 0.0021 0.008 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0321 0.2339 0.4594
Trypanosoma brucei calpain-like protein, putative 0.0041 0.0229 0.0428
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0321 0.2339 0.233
Loa Loa (eye worm) hypothetical protein 0.0231 0.166 0.165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0589 0.4354 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0021 0.008 0.0036
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.0965 0.0954
Schistosoma mansoni peptidylglycine monooxygenase 0.0123 0.0843 0.0833
Echinococcus multilocularis cysteine protease 0.0589 0.4354 0.4329
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Schistosoma mansoni cyclins 0.0021 0.008 0.0068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0044 0.0032
Echinococcus granulosus cathepsin b 0.1338 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.0965 0.0954
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0229 0.0428
Plasmodium vivax unspecified product 0.0321 0.2339 0.531
Entamoeba histolytica cysteine protease, putative 0.0139 0.0965 0.2195
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0188 0.0407
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0139 0.0965 0.2113
Leishmania major cathepsin L-like protease 0.0685 0.5077 1
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0231 0.166 0.165
Giardia lamblia Cathepsin B precursor 0.051 0.3759 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0589 0.4354 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0139 0.0965 0.2195
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.0965 0.0954
Brugia malayi Cathepsin L-like cysteine proteinase 0.0406 0.298 0.298
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0685 0.5077 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0139 0.0965 0.2195
Trypanosoma brucei calpain-like protein, putative 0.0041 0.0229 0.0428
Brugia malayi hypothetical protein 0.0017 0.0044 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0685 0.5077 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0589 0.4354 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0685 0.5077 1
Schistosoma mansoni calpain-7 (C02 family) 0.0041 0.0229 0.0217
Leishmania major cathepsin L-like protease 0.0589 0.4354 0.8573
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0188 0.0177
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0272 0.0261
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0589 0.4354 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0139 0.0965 0.2113
Loa Loa (eye worm) hypothetical protein 0.0182 0.1292 0.1282
Brugia malayi Papain family cysteine protease containing protein 0.0589 0.4354 0.4354
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0406 0.298 0.6836
Schistosoma mansoni cathepsin S (C01 family) 0.0139 0.0965 0.0954
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Brugia malayi Dopamine receptor protein 2 0.0017 0.0044 0.0044
Schistosoma mansoni myosin xvIII 0.0017 0.0044 0.0032
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0017 0.0044 0.0032
Leishmania major pyruvate kinase 0.0036 0.0188 0.0349
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0188 0.0177
Loa Loa (eye worm) hypothetical protein 0.0104 0.0703 0.0692
Echinococcus multilocularis cyclin B 0.0021 0.008 0.0036
Giardia lamblia Cathepsin L precursor 0.0139 0.0965 0.2452
Loa Loa (eye worm) hypothetical protein 0.0104 0.0703 0.0692
Loa Loa (eye worm) hypothetical protein 0.0104 0.0703 0.0692
Entamoeba histolytica cysteine proteinase 1, putative 0.0321 0.2339 0.5359
Echinococcus granulosus cathepsin l1 0.0406 0.298 0.2949
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0139 0.0965 0.2195
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Loa Loa (eye worm) RNA binding protein 0.0065 0.0407 0.0396
Leishmania major cathepsin L-like protease 0.0685 0.5077 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0406 0.298 0.6836
Brugia malayi hypothetical protein 0.0017 0.0044 0.0044
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0188 0.0349
Echinococcus granulosus cathepsin L 0.0139 0.0965 0.0925
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0032
Giardia lamblia Cathepsin L precursor 0.0139 0.0965 0.2452
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0272 0.0261
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0407 0.0396
Brugia malayi Cathepsin L-like precursor 0.0589 0.4354 0.4354

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1 uM Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E ChEMBL. No reference
IC50 (binding) = 1 uM Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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