Detailed information for compound 1505198

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 320.411 | Formula: C18H16N4S
  • H donors: 2 H acceptors: 2 LogP: 4.52 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)CCNc1scc(n1)c1ccc2c(c1)cn[nH]2
  • InChi: 1S/C18H16N4S/c1-2-4-13(5-3-1)8-9-19-18-21-17(12-23-18)14-6-7-16-15(10-14)11-20-22-16/h1-7,10-12H,8-9H2,(H,19,21)(H,20,22)
  • InChiKey: CULJEMIZFZIMCZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens Rho-associated, coiled-coil containing protein kinase 2 Starlite/ChEMBL References
Homo sapiens aurora kinase B Starlite/ChEMBL References
Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 4 Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing Get druggable targets OG5_131020 All targets in OG5_131020
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Rho-associated protein kinase 1, putative Get druggable targets OG5_131020 All targets in OG5_131020
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis rho associated protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Echinococcus granulosus serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Loa Loa (eye worm) STE/STE20/PAKB protein kinase Get druggable targets OG5_131977 All targets in OG5_131977
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus rho-associated protein kinase 1 Get druggable targets OG5_131020 All targets in OG5_131020
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131020 All targets in OG5_131020
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi serine/threonine-protein kinase PAK 7 Get druggable targets OG5_131977 All targets in OG5_131977
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis AGC family protein kinase 0.007 0.0075 0.011
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.029 0.0372 0.0372
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.029 0.0372 0.0372
Brugia malayi serine/threonine protein kinase 6 0.007 0.0075 0.0069
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.006 0.0062 0.0062
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0194 0.0243 0.0237
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0021 0.001 0.001
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.029 0.0372 0.0372
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0062 0.0061
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0062 0.0088
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0296 0.0381 0.0381
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Onchocerca volvulus Tyrosine kinase homolog 0.0171 0.0211 0.0239
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Entamoeba histolytica protein kinase , putative 0.007 0.0075 0.011
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.4686 0.63 1
Onchocerca volvulus 0.029 0.0372 0.0497
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.029 0.0372 0.0372
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.029 0.0372 0.0372
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.029 0.0372 0.0372
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.029 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0004
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0293 0.0376 0.0376
Entamoeba histolytica protein tyrosine phosphatase, putative 0.4686 0.63 1
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Brugia malayi serine/threonine kinase 12 0.007 0.0075 0.0069
Onchocerca volvulus 0.029 0.0372 0.0497
Trichomonas vaginalis STE family protein kinase 0.0021 0.001 0.0005
Schistosoma mansoni protein kinase 0.0021 0.001 0.001
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0021 0.001 0.001
Plasmodium vivax serine/threonine protein kinase 6, putative 0.007 0.0075 1
Brugia malayi serine/threonine-protein kinase PAK 7 0.0223 0.0281 0.0275
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.029 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Schistosoma mansoni tyrosine kinase 0.002 0.0008 0.0008
Brugia malayi Protein-tyrosine phosphatase 0.029 0.0372 0.0366
Trichomonas vaginalis AGC family protein kinase 0.007 0.0075 0.011
Brugia malayi serine/threonine-protein kinase 6 0.007 0.0075 0.0069
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0075 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.0221 0.0221
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.029 0.0372 0.0372
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0548 0.072 0.0719
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Giardia lamblia Kinase, CMGC GSK 0.006 0.0062 0.0083
Echinococcus multilocularis rho associated protein kinase 0.0178 0.0221 0.0221
Onchocerca volvulus 0.029 0.0372 0.0497
Schistosoma mansoni protein tyrosine phosphatase 0.029 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Loa Loa (eye worm) AUR protein kinase 0.007 0.0075 0.0074
Onchocerca volvulus 0.029 0.0372 0.0497
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.029 0.0372 0.0372
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.007 0.0075 0.0075
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Toxoplasma gondii aurora kinase 0.007 0.0075 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Trypanosoma cruzi hypothetical protein, conserved 0.1444 0.1929 1
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Brugia malayi Protein-tyrosine phosphatase 0.029 0.0372 0.0366
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.029 0.0372 0.0372
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.029 0.0372 0.0372
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.029 0.0372 0.0372
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0019 0.0006 0.0006
Loa Loa (eye worm) protein-tyrosine phosphatase 0.029 0.0372 0.0371
Onchocerca volvulus 0.0175 0.0218 0.025
Echinococcus granulosus aurora kinase A 0.007 0.0075 0.0075
Echinococcus multilocularis PAK box P21 Rho binding 0.0019 0.0006 0.0006
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.029 0.0372 0.0372
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.029 0.0372 0.0372
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.0243 0.0243
Brugia malayi hypothetical protein 0.029 0.0372 0.0366
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Onchocerca volvulus 0.029 0.0372 0.0497
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.4686 0.63 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1444 0.1929 0.3055
Onchocerca volvulus 0.029 0.0372 0.0497
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0019 0.0006 0.0006
Trichomonas vaginalis AGC family protein kinase 0.007 0.0075 0.011
Brugia malayi Dual specificity protein phosphatase CDC14B 0.029 0.0372 0.0366
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.3241 0.4352 0.5
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.007 0.0075 0.011
Schistosoma mansoni hypothetical protein 0.0019 0.0006 0.0006
Onchocerca volvulus 0.029 0.0372 0.0497
Entamoeba histolytica protein kinase, putative 0.007 0.0075 0.011
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.4686 0.63 1
Trichomonas vaginalis pten, drome, putative 0.029 0.0372 0.0581
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.4686 0.63 1
Onchocerca volvulus 0.029 0.0372 0.0497
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0194 0.0243 0.0242
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.029 0.0372 0.0372
Onchocerca volvulus 0.029 0.0372 0.0497
Trichomonas vaginalis STE family protein kinase 0.0021 0.001 0.0005
Echinococcus granulosus PAK box P21 Rho binding 0.0019 0.0006 0.0006
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.006 0.0062 0.0062
Leishmania major protein-tyrosine phosphatase 1-like protein 0.029 0.0372 0.1661
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0019 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.029 0.0372 0.0372
Echinococcus granulosus glycogen synthase kinase 3 beta 0.006 0.0062 0.0062
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.029 0.0372 0.0371
Trypanosoma cruzi hypothetical protein, conserved 0.1444 0.1929 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Entamoeba histolytica p21-activated kinase 0.0021 0.001 0.0005
Echinococcus granulosus protein tyrosine phosphatase n9 0.029 0.0372 0.0372
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.029 0.0372 0.0581
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.029 0.0372 0.0372
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.029 0.0372 0.0372
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.1444 0.1929 1
Echinococcus multilocularis PAK box P21 Rho binding 0.0021 0.001 0.001
Schistosoma mansoni protein kinase 0.0021 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Brugia malayi Protein kinase domain 0.0021 0.001 0.0003
Loa Loa (eye worm) protein-tyrosine phosphatase 0.029 0.0372 0.0371
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0194 0.0243 0.0242
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.4686 0.63 1
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0075 0.011
Entamoeba histolytica protein kinase, putative 0.0021 0.001 0.0005
Onchocerca volvulus 0.029 0.0372 0.0497
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0021 0.001 0.001
Giardia lamblia Aurora kinase 0.007 0.0075 0.0104
Onchocerca volvulus 0.029 0.0372 0.0497
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0019 0.0006 0.0006
Plasmodium falciparum serine/threonine protein kinase, putative 0.007 0.0075 1
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0194 0.0243 0.0243
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.029 0.0372 0.0372
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.029 0.0372 0.0371
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0194 0.0243 0.0291
Echinococcus multilocularis protein tyrosine phosphatase n9 0.029 0.0372 0.0372
Loa Loa (eye worm) protein-tyrosine phosphatase 0.029 0.0372 0.0371
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.4686 0.63 0.5
Loa Loa (eye worm) protein-tyrosine phosphatase 0.029 0.0372 0.0371
Trichomonas vaginalis AGC family protein kinase 0.007 0.0075 0.011
Loa Loa (eye worm) protein-tyrosine phosphatase 0.029 0.0372 0.0371
Schistosoma mansoni protein-tyrosine phosphatase n9 0.029 0.0372 0.0372
Onchocerca volvulus 0.029 0.0372 0.0497
Schistosoma mansoni protein tyrosine phosphatase 0.029 0.0372 0.0372
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.029 0.0372 0.0372
Onchocerca volvulus 0.029 0.0372 0.0497
Loa Loa (eye worm) protein-tyrosine phosphatase 0.029 0.0372 0.0371
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.029 0.0372 0.0372
Brugia malayi hypothetical protein 0.029 0.0372 0.0366
Trichomonas vaginalis STE family protein kinase 0.0021 0.001 0.0005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.029 0.0372 0.0371
Onchocerca volvulus 0.4686 0.63 1
Echinococcus granulosus roundabout 2 0.0018 0.0005 0.0005
Leishmania major protein kinase, putative 0.007 0.0075 0.0073
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.4686 0.63 1
Echinococcus granulosus serine:threonine protein kinase 12 B 0.007 0.0075 0.0075
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Entamoeba histolytica protein tyrosine phosphatase, putative 0.4686 0.63 1
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.029 0.0372 0.0366
Loa Loa (eye worm) protein-tyrosine phosphatase 0.029 0.0372 0.0371
Brugia malayi Protein-tyrosine phosphatase 1 0.029 0.0372 0.0366
Trypanosoma brucei protein tyrosine phosphatase 1 0.029 0.0372 0.1661
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0062 0.0061
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Brugia malayi Protein kinase domain containing protein 0.0548 0.072 0.0714
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.029 0.0372 0.0372
Echinococcus multilocularis hypothetical protein 0.029 0.0372 0.0372
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0008 0.0008
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0194 0.0243 0.0243
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.0227 0.0221
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.029 0.0372 0.0372
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0296 0.0381 0.0381
Echinococcus granulosus protein kinase shaggy 0.006 0.0062 0.0062
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.029 0.0372 0.0371
Leishmania major hypothetical protein, conserved 0.1444 0.1929 1
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0019 0.0006 0.0006
Loa Loa (eye worm) protein-tyrosine phosphatase 0.029 0.0372 0.0371
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.029 0.0372 0.0372
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.029 0.0372 0.0372
Onchocerca volvulus 0.029 0.0372 0.0497
Loa Loa (eye worm) AUR protein kinase 0.007 0.0075 0.0074
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0021 0.001 0.001
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0296 0.0381 0.0381
Schistosoma mansoni hypothetical protein 0.0019 0.0006 0.0006
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0296 0.0381 0.0381
Entamoeba histolytica protein kinase, putative 0.0021 0.001 0.0005
Echinococcus granulosus rho-associated protein kinase 1 0.0178 0.0221 0.0221
Giardia lamblia Kinase, CMGC GSK 0.006 0.0062 0.0083
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1444 0.1929 0.3055
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.029 0.0372 0.0372
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.029 0.0372 0.0372
Onchocerca volvulus 0.029 0.0372 0.0497
Onchocerca volvulus 0.0178 0.0221 0.0255
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.029 0.0372 0.1661
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0204 0.0256 0.0256
Onchocerca volvulus 0.0167 0.0206 0.0231
Loa Loa (eye worm) protein-tyrosine phosphatase 0.029 0.0372 0.0371
Trichomonas vaginalis STE family protein kinase 0.0021 0.001 0.0005
Trichomonas vaginalis STE family protein kinase 0.0021 0.001 0.0005
Trypanosoma cruzi aurora B kinase, putative 0.007 0.0075 0.0073
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.029 0.0372 0.0372
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0062 0.0088
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.029 0.0372 0.0372
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0021 0.001 0.001
Onchocerca volvulus 0.029 0.0372 0.0497
Entamoeba histolytica protein tyrosine phosphatase, putative 0.029 0.0372 0.0581
Echinococcus multilocularis protein kinase shaggy 0.006 0.0062 0.0062
Onchocerca volvulus 0.029 0.0372 0.0497
Schistosoma mansoni pcd6 interacting protein-related 0.029 0.0372 0.0372
Brugia malayi hypothetical protein 0.029 0.0372 0.0366
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.029 0.0372 0.0372
Entamoeba histolytica protein kinase, putative 0.006 0.0062 0.0088
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0001 0.0001
Giardia lamblia Protein tyrosine phosphatase 0.029 0.0372 0.0576
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.029 0.0372 0.0372
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0223 0.0281 0.028
Echinococcus granulosus twitchin 0.0017 0.0003 0.0003
Onchocerca volvulus 0.029 0.0372 0.0497
Onchocerca volvulus 0.029 0.0372 0.0497
Loa Loa (eye worm) protein-tyrosine phosphatase 0.029 0.0372 0.0371
Schistosoma mansoni protein kinase 0.0019 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0019 0.0006 0.0006
Trypanosoma brucei aurora B kinase 0.007 0.0075 0.0073
Onchocerca volvulus 4.1 G protein, putative homolog 0.029 0.0372 0.0497
Schistosoma mansoni protein tyrosine phosphatase 0.029 0.0372 0.0372
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0296 0.0381 0.0381
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.029 0.0372 0.0371
Onchocerca volvulus 0.029 0.0372 0.0497
Loa Loa (eye worm) protein-tyrosine phosphatase 0.029 0.0372 0.0371
Schistosoma mansoni cell adhesion molecule 0.0015 0.0001 0.0001
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.029 0.0372 0.0372
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.007 0.0075 0.011
Onchocerca volvulus 0.029 0.0372 0.0497
Onchocerca volvulus 0.029 0.0372 0.0497
Entamoeba histolytica protein kinase, putative 0.0021 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.4686 0.63 0.6297
Entamoeba histolytica protein tyrosine phosphatase, putative 0.029 0.0372 0.0581
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.029 0.0372 0.0372
Schistosoma mansoni protein kinase 0.0021 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Entamoeba histolytica protein kinase, putative 0.0021 0.001 0.0005
Brugia malayi Protein kinase domain containing protein 0.0194 0.0243 0.0237
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.029 0.0372 0.1661
Loa Loa (eye worm) AUR protein kinase 0.007 0.0075 0.0074
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.029 0.0372 0.0372
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0062 0.0088
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Onchocerca volvulus 0.029 0.0372 0.0497
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.029 0.0372 0.0372
Brugia malayi intracellular kinase 0.006 0.0062 0.0055
Brugia malayi hypothetical protein 0.029 0.0372 0.0366
Echinococcus multilocularis aurora kinase A 0.007 0.0075 0.0075
Entamoeba histolytica protein kinase, putative 0.007 0.0075 0.011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0004
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.029 0.0372 0.0372
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Echinococcus multilocularis roundabout 2 0.0018 0.0005 0.0005
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.029 0.0372 0.0372
Schistosoma mansoni receptor protein tyrosine phosphatase 0.029 0.0372 0.0372
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.4686 0.63 0.6299
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0183 0.0227 0.0226
Schistosoma mansoni protein kinase 0.007 0.0075 0.0075
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.029 0.0372 0.0372
Echinococcus multilocularis 0.029 0.0372 0.0372
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.4686 0.63 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.029 0.0372 0.0372
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0062 0.0088
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0021 0.001 0.001
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.007 0.0075 0.011
Leishmania major tyrosine specific protein phosphatase, putative 0.029 0.0372 0.1661
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.029 0.0372 0.1661
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0005
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.029 0.0372 0.0372
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Loa Loa (eye worm) protein tyrosine phosphatase 0.029 0.0372 0.0371
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0204 0.0256 0.0256
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.029 0.0372 0.0372
Brugia malayi Protein-tyrosine phosphatase containing protein 0.029 0.0372 0.0366
Schistosoma mansoni rgs-gaip interacting protein gipc 0.029 0.0372 0.0372
Loa Loa (eye worm) protein-tyrosine phosphatase 0.029 0.0372 0.0371
Loa Loa (eye worm) protein-tyrosine phosphatase 0.029 0.0372 0.0371
Loa Loa (eye worm) hypothetical protein 0.029 0.0372 0.0371
Brugia malayi hypothetical protein 0.029 0.0372 0.0366

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) Inhibition of JAK2 ChEMBL. 21288717
Ki (binding) Inhibition of EGFR ChEMBL. 21288717
Ki (binding) = 0.364 uM Inhibition of Rock2 ChEMBL. 21288717
Ki (binding) = 0.81 uM Inhibition of aurora 2 ChEMBL. 21288717
Ki (binding) > 3.75 uM Inhibition of Pak4 ChEMBL. 21288717
Ki (binding) > 5.45 uM Inhibition of GSK3-beta ChEMBL. 21288717
Ki (binding) > 8.75 uM Inhibition of Pim1 ChEMBL. 21288717
Ki (binding) > 8.88 uM Inhibition of KDR ChEMBL. 21288717

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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