Detailed information for compound 1517100

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 628.668 | Formula: C30H33FN4O8S
  • H donors: 3 H acceptors: 5 LogP: 3.06 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H](N1C[C@H](C)[C@H](Oc2c(C1=O)cccc2NC(=O)Nc1ccc2c(c1)OCO2)CN(S(=O)(=O)c1ccc(cc1)F)C)C
  • InChi: 1S/C30H33FN4O8S/c1-18-14-35(19(2)16-36)29(37)23-5-4-6-24(33-30(38)32-21-9-12-25-26(13-21)42-17-41-25)28(23)43-27(18)15-34(3)44(39,40)22-10-7-20(31)8-11-22/h4-13,18-19,27,36H,14-17H2,1-3H3,(H2,32,33,38)/t18-,19+,27+/m0/s1
  • InChiKey: VHKVVFSFBAQREB-DSNGTPCMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 3 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0022 0.0108 0.6196
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0025 0.0022
Schistosoma mansoni sodium-dependent amino acid transporter 0.0015 0.0056 0.0056
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0258 0.0255
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0392 0.0841
Schistosoma mansoni hypothetical protein 0.0031 0.0168 0.0168
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0011 0.0025 0.0025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0064 0.3365
Trypanosoma brucei prostaglandin f synthase 0.0031 0.0167 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0009 0.0012 0.0549
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0167 0.0951
Echinococcus granulosus aldo keto reductase 0.0031 0.0167 0.0165
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0108 0.0609
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0015 0.0056 0.0053
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0025 0.0022
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0019 0.0016
Brugia malayi hypothetical protein 0.0236 0.1629 0.3509
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0015 0.0056 0.0056
Schistosoma mansoni rab6-interacting 0.0236 0.1629 0.1629
Schistosoma mansoni aldo-keto reductase 0.0031 0.0167 0.0167
Entamoeba histolytica aldose reductase, putative 0.0031 0.0167 0.6467
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0108 0.0609
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0167 0.0951
Brugia malayi hypothetical protein 0.0015 0.0056 0.0115
Loa Loa (eye worm) hypothetical protein 0.0098 0.0643 0.1381
Entamoeba histolytica P-glycoprotein-2 0.0022 0.0108 0.4142
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0167 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0019 0.0035
Brugia malayi ecdysteroid receptor 0.001 0.0019 0.0035
Schistosoma mansoni hypothetical protein 0.0067 0.0423 0.0423
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0022 0.0108 0.6196
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0115
Entamoeba histolytica alcohol dehydrogenase, putative 0.0009 0.0012 0.0355
Onchocerca volvulus 0.0022 0.0108 0.0228
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0167 0.0951
Echinococcus multilocularis GPCR, family 2 0.0031 0.0168 0.0165
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1121 0.6453
Loa Loa (eye worm) RNA binding protein 0.0062 0.0392 0.0841
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0265 0.0262
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0392 0.0392
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0167 0.0165
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0071 0.2867
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0019 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0012 0.0052
Echinococcus multilocularis voltage gated potassium channel subunit 0.0009 0.0012 0.0009
Trichomonas vaginalis abcb9, putative 0.0022 0.0108 0.0609
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0392 0.0841
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0168 0.0165
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0108 0.0609
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0019 0.0016
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0168 0.0357
Echinococcus multilocularis lipoxygenase domain containing protein 0.0236 0.1629 0.1626
Echinococcus multilocularis aldehyde reductase 0.0022 0.0104 0.0101
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0108 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0265 0.0265
Trypanosoma cruzi aldo-keto reductase 0.0031 0.0167 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0115
Entamoeba histolytica P-glycoprotein-1 0.0022 0.0108 0.4142
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0019 0.0035
Brugia malayi nuclear receptor NHR-88 0.001 0.0019 0.0035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0112 0.0237
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0167 0.0951
Brugia malayi DIX domain containing protein 0.0011 0.0025 0.0047
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0056 0.0273
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0019 0.0035
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0025 0.0025
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0056 0.283
Schistosoma mansoni multidrug resistance protein 0.0022 0.0108 0.0108
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0016 0.006 0.033
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1121 0.6453
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0258 0.0258
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0167 0.0165
Onchocerca volvulus 0.0031 0.0167 0.0356
Brugia malayi hypothetical protein 0.0236 0.1629 0.3509
Loa Loa (eye worm) oxidoreductase 0.0031 0.0167 0.0356
Brugia malayi Doublecortin family protein 0.0236 0.1629 0.3509
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0265 0.0265
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0019 0.0035
Brugia malayi hypothetical protein 0.0011 0.0025 0.0047
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0035
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0251 0.1736 0.3741
Brugia malayi RNA binding protein 0.0062 0.0392 0.0841
Entamoeba histolytica hypothetical protein 0.0043 0.0258 1
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0015 0.0056 0.0053
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0147
Onchocerca volvulus 0.0089 0.0582 0.1251
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0008 0.0003 0.0003
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0168 0.0357
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0167 0.0165
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0168 0.0357
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0108 0.0106
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0112 0.6458
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0108 0.0106
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0112 0.6458
Onchocerca volvulus 0.0031 0.0167 0.0356
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0019 0.0035
Plasmodium vivax multidrug resistance protein 1, putative 0.0022 0.0108 0.0597
Echinococcus granulosus lipoxygenase domain containing protein 0.0236 0.1629 0.1626
Plasmodium falciparum multidrug resistance protein 1 0.0022 0.0108 0.0597
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0167 0.0356
Plasmodium falciparum amino acid transporter, putative 0.0015 0.0056 0.0273
Echinococcus granulosus Polycystic kidney disease protein 0.0236 0.1629 0.1626
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0056 0.0053
Entamoeba histolytica hypothetical protein 0.0043 0.0258 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0025 0.0022
Brugia malayi N-terminal motif family protein 0.0218 0.15 0.3233
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0056 0.0056
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0423 0.0907
Echinococcus granulosus aldehyde reductase 0.0022 0.0104 0.0101
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0009 0.0012 0.0052
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0167 0.0951
Echinococcus granulosus aldo keto reductase 0.0031 0.0167 0.0165
Onchocerca volvulus 0.0015 0.0056 0.0115
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0025 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0035
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0025 0.0022
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0167 0.0951
Echinococcus multilocularis aldo keto reductase 0.0031 0.0167 0.0165
Leishmania major aldo-keto reductase-like protein 0.0031 0.0167 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0019 0.0016
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0019 0.0016
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0167 0.0951
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0064 0.3365
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0167 0.0165
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0023 0.0112 0.0237
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0112 0.6458
Schistosoma mansoni polycystin 1-related 0.0236 0.1629 0.1629
Mycobacterium ulcerans hypothetical protein 0.0023 0.0112 0.6458
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0108 0.0106
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0019 0.0016
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0056 0.0053
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0056 0.0056
Schistosoma mansoni loxhd1 0.0236 0.1629 0.1629
Plasmodium vivax amine transporter, putative 0.0015 0.0056 0.0273
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0112 0.6458
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1121 0.6453
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0108 0.0609
Trichomonas vaginalis abcb9, putative 0.0022 0.0108 0.0609
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0019 0.0035
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0108 0.0609
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0167 0.0165
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0108 0.0609
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0009 0.0012 0.002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0265 0.0262
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0011 0.0025 0.0022
Treponema pallidum sodium- and chloride- dependent transporter 0.0089 0.0582 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0147
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0022 0.0108 0.0609
Echinococcus granulosus hypothetical protein 0.0031 0.0167 0.0165
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0112 0.6458
Loa Loa (eye worm) hypothetical protein 0.0022 0.0106 0.0224
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0112 0.6458
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0115
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0019 0.0016
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.5562 0.556
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0009 0.0012 0.002
Loa Loa (eye worm) norepinephrine transporter 0.0089 0.0582 0.1251
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0019 0.0035
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.0108 0.0106
Loa Loa (eye worm) oxidoreductase 0.0031 0.0167 0.0356
Loa Loa (eye worm) hypothetical protein 0.0022 0.0108 0.0228
Toxoplasma gondii hypothetical protein 0.0015 0.0056 0.283
Schistosoma mansoni coup transcription factor 0.001 0.0019 0.0019
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0167 0.0951
Brugia malayi nuclear hormone receptor 0.001 0.0019 0.0035
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0108 0.0106
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.0167 1
Echinococcus multilocularis serotonin transporter 0.0089 0.0582 0.058
Entamoeba histolytica P-glycoprotein 5, putative 0.0022 0.0108 0.4142
Brugia malayi hypothetical protein 0.0043 0.0258 0.055
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0112 0.4302
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0011 0.0025 0.0047
Loa Loa (eye worm) hypothetical protein 0.0031 0.0168 0.0357
Loa Loa (eye worm) hypothetical protein 0.0236 0.1629 0.3509
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0019 0.0019
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0108 0.0609
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0108 0.0609
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0115
Loa Loa (eye worm) hypothetical protein 0.0023 0.0112 0.0237
Echinococcus granulosus GPCR family 2 0.0031 0.0168 0.0165
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0115
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0258 0.0255
Echinococcus granulosus multidrug resistance protein 1 0.0016 0.006 0.0057
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0167 0.0165
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0008 0.0003 0.0003
Giardia lamblia Aldose reductase 0.0031 0.0167 0.5
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0089 0.0582 0.1251
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0643 0.1381
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0167 0.0356
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0108 0.0609
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0167 0.0165
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0167 0.0951
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0035
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1121 0.6453
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0643 0.1381
Schistosoma mansoni multidrug resistance protein 0.0022 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0019 0.0035
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0108 0.0609
Loa Loa (eye worm) hypothetical protein 0.0031 0.0167 0.0356
Onchocerca volvulus 0.0015 0.0056 0.0115
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1184 0.6818
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0019 0.0016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0047
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0071 0.3795
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0022 0.0108 0.6196
Echinococcus multilocularis Polycystic kidney disease protein 0.0236 0.1629 0.1626
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0019 0.0035
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0019 0.0035
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0019 0.0019
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0112 0.4302
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0019 0.0035
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0108 0.0106
Onchocerca volvulus 0.0658 0.4636 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0115
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0147
Echinococcus granulosus RUN 0.0236 0.1629 0.1626
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0167 0.0165
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0112 0.4302
Loa Loa (eye worm) oxidoreductase 0.0031 0.0167 0.0356
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0392 0.0841
Echinococcus multilocularis multidrug resistance protein 1 0.0016 0.006 0.0057
Loa Loa (eye worm) oxidoreductase 0.0031 0.0167 0.0356
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0392 0.0392
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0056 0.283
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1121 0.6453
Loa Loa (eye worm) serotonin transporter b 0.0089 0.0582 0.1251
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0167 0.0951
Toxoplasma gondii hypothetical protein 0.0015 0.0056 0.283
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0108 0.0609
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0019 0.0016
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0056 0.0053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0019 0.0016
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0025 0.0022
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0112 0.0237
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0108 0.0609
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.1736 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0167 0.0165
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0012 0.0052
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0008 0.0003 0.0003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0019 0.0035
Entamoeba histolytica hypothetical protein 0.0043 0.0258 1
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0022 0.0108 1
Loa Loa (eye worm) doublecortin family protein 0.0236 0.1629 0.3509
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0392 0.0392
Entamoeba histolytica hypothetical protein 0.0043 0.0258 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0265 0.0265
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0056 0.0115
Loa Loa (eye worm) DIX domain-containing protein 0.0011 0.0025 0.0047
Echinococcus multilocularis RUN 0.0236 0.1629 0.1626
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.1736 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0071 0.3795
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0019 0.0035
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0112 0.6458
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0015 0.0056 0.0053
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0047
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0167 0.0951
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0019 0.0035
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0064 0.3365
Brugia malayi multidrug resistance protein 3 0.0022 0.0108 0.0228
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0056 0.0115
Schistosoma mansoni ras GTP exchange factor 0.0008 0.0003 0.0003
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0056 0.0115
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.1736 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0236 0.1629 0.1626
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.1736 1
Echinococcus granulosus tar DNA binding protein 0.0062 0.0392 0.039
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0108 0.0609
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0022 0.0108 0.0228
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0056 0.0053
Echinococcus multilocularis aldo keto reductase 0.0031 0.0167 0.0165
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0012 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0019 0.0035
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.1121 0.2414
Echinococcus granulosus multidrug resistance protein 1 0.0016 0.006 0.0057
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0019 0.0035
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0147
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0167 0.0951
Entamoeba histolytica aldose reductase, putative 0.0031 0.0167 0.6467
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0025 0.0047
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0019 0.0016
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0265 0.0566
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0025 0.0047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0265 0.0262
Entamoeba histolytica P-glycoprotein-5 0.0022 0.0108 0.4142
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0167 0.0951
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0112 0.0237
Trypanosoma brucei aldo-keto reductase, putative 0.0031 0.0167 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0035
Plasmodium vivax multidomain scavenger receptor, putative 0.0236 0.1629 1
Schistosoma mansoni lipoxygenase 0.0987 0.6975 0.6975
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0167 0.0165
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0392 0.0392
Leishmania major prostaglandin f synthase, putative 0.0031 0.0167 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0056 0.0056
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0071 0.0366
Onchocerca volvulus 0.0031 0.0167 0.0356
Onchocerca volvulus 0.0031 0.0167 0.0356
Onchocerca volvulus 0.001 0.0019 0.0035
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0025 0.0022
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0115
Loa Loa (eye worm) hypothetical protein 0.0658 0.4636 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0019 0.0019
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0167 0.0165
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0056 0.0053
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0643 0.1381
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.0104 0.5922
Entamoeba histolytica P-glycoprotein-2 0.0022 0.0108 0.4142
Mycobacterium ulcerans oxidoreductase 0.0031 0.0167 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0089 0.0582 0.0582
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0019 0.0035
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0167 0.0165
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0112 0.6458
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0009 0.0012 0.0009
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0167 0.0951
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0056 0.0053
Brugia malayi steroid hormone receptor 0.001 0.0019 0.0035
Trichomonas vaginalis abcb9, putative 0.0022 0.0108 0.0609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0064 0.3365
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0031 0.0167 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0056 0.0056
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0112 0.6458
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0019 0.0016
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0108 0.0609
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0019 0.0019
Onchocerca volvulus 0.0236 0.1629 0.3509
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0056 0.0056
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0167 0.0165
Leishmania major p-glycoprotein 0.0022 0.0108 0.6196
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0056 0.0056
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0025 0.0022
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0056 0.0115
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0015 0.0056 0.0115
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0108 0.0106
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0108 0.0609
Trichomonas vaginalis taga, putative 0.0022 0.0108 0.0609
Schistosoma mansoni potassium channel beta 0.0009 0.0012 0.0012
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0167 0.0165
Plasmodium falciparum transporter, putative 0.0015 0.0056 0.0273
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0167 0.0356
Entamoeba histolytica aldose reductase, putative 0.0031 0.0167 0.6467
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0108 0.0106
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0265 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0019 0.0035
Toxoplasma gondii hypothetical protein 0.0011 0.0025 0.0827
Schistosoma mansoni dishevelled 0.0011 0.0025 0.0025
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0112 0.0237
Echinococcus multilocularis aldo keto reductase 0.0031 0.0167 0.0165
Schistosoma mansoni hypothetical protein 0.0031 0.0168 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0019 0.0035
Schistosoma mansoni hypothetical protein 0.0236 0.1629 0.1629
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0112 0.6458
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1184 0.6818
Onchocerca volvulus 0.0015 0.0056 0.0115
Schistosoma mansoni aldo-keto reductase 0.0031 0.0167 0.0167
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.1736 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0168 0.0165
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0015 0.0056 0.0056
Plasmodium falciparum LCCL domain-containing protein 0.0236 0.1629 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0112 0.6458
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0022 0.0106 0.0104
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0011 0.0025 0.0047
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0167 0.0165
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0015 0.0056 0.0053
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0056 0.283
Loa Loa (eye worm) oxidoreductase 0.0031 0.0167 0.0356
Loa Loa (eye worm) hypothetical protein 0.0022 0.0108 0.0228
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.1736 1
Loa Loa (eye worm) hypothetical protein 0.0218 0.15 0.3233
Toxoplasma gondii aldose reductase, putative 0.0031 0.0167 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0108 0.0609
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.0108 0.0106
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0236 0.1629 0.3509
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0019 0.0035
Schistosoma mansoni hypothetical protein 0.0043 0.0258 0.0258
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0167 0.0951
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0251 0.1736 0.3741
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0167 0.0951
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0167 0.0165
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0019 0.0016
Schistosoma mansoni thyroid hormone receptor 0.001 0.0019 0.0019
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0167 0.0165
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0147
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0108 0.0609
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0031 0.0167 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0108 0.0609
Loa Loa (eye worm) solute carrier family 6 member 4 0.0089 0.0582 0.1251
Entamoeba histolytica P-glyco protein 6, putative 0.0022 0.0108 0.4142
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0108 0.0609
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0015 0.0056 0.0053
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0108 0.0106
Giardia lamblia Aldose reductase 0.0031 0.0167 0.5
Schistosoma mansoni pol-related 0.0031 0.0167 0.0167
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0108 0.0609
Brugia malayi ABC transporter family protein 0.0022 0.0108 0.0228
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0056 0.0115
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0019 0.0016
Echinococcus granulosus voltage gated potassium channel subunit 0.0009 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0067 0.0423 0.0907
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0019 0.0016
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0022 0.0108 0.0609
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0008 0.0003 0.0003
Onchocerca volvulus 0.0031 0.0167 0.0356
Schistosoma mansoni nuclear hormone receptor 0.001 0.0019 0.0019
Schistosoma mansoni thyroid hormone receptor 0.001 0.0019 0.0019
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0167 0.0165
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0167 0.0951
Onchocerca volvulus 0.0236 0.1629 0.3509
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0167 0.0951
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0168 0.0165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0019 0.0035
Brugia malayi TAR-binding protein 0.0062 0.0392 0.0841
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0035
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0108 0.0106
Echinococcus granulosus serotonin transporter 0.0089 0.0582 0.058
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0108 0.0609
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0019 0.0035
Schistosoma mansoni dishevelled 0.0011 0.0025 0.0025
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0019 0.0035
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0167 0.0356
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0035
Trypanosoma cruzi aldo/keto reductase, putative 0.0031 0.0167 1
Echinococcus granulosus Pleckstrin G protein interacting region 0.0011 0.0025 0.0022
Brugia malayi regulator of G-protein signaling egl-10 0.0011 0.0025 0.0047
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0108 0.0609
Entamoeba histolytica P-glycoprotein-2, putative 0.0022 0.0108 0.4142
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0019 0.0035
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0019 0.0016
Loa Loa (eye worm) hypothetical protein 0.0089 0.0582 0.1251
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0035
Loa Loa (eye worm) multidrug resistance protein 3 0.0022 0.0108 0.0228
Echinococcus granulosus aldo keto reductase 0.0031 0.0167 0.0165
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0019 0.0016
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0168 0.0165
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0019 0.0035
Schistosoma mansoni hypothetical protein 0.0031 0.0168 0.0168
Echinococcus multilocularis aldo keto reductase 0.0031 0.0167 0.0165
Brugia malayi cyclic AMP-response element binding protein 1 gamma 1, putative 0.0658 0.4636 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0108 0.0609
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.15 0.3233
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0025 0.0025
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0012 0.0052
Entamoeba histolytica alcohol dehydrogenase, putative 0.0009 0.0012 0.0355
Schistosoma mansoni dep domain containing protein 0.0011 0.0025 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0392 0.0392
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0108 0.0106
Schistosoma mansoni smdr2 0.0022 0.0108 0.0108
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0108 0.0106
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1121 0.6453
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0022 0.0108 0.6196
Loa Loa (eye worm) hypothetical protein 0.0089 0.0582 0.1251
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0167 0.0165
Schistosoma mansoni rab6-interacting 0.0236 0.1629 0.1629
Echinococcus granulosus lipoxygenase domain containing protein 0.0236 0.1629 0.1626
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1121 0.6453
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0112 0.6458
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0071 0.0366
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0031 0.0167 1
Brugia malayi NADH-dependent xylose reductase 0.0009 0.0012 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0112 0.6458
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0392 0.039
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0108 0.0609
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0265 0.0566
Brugia malayi hypothetical protein 0.0011 0.0025 0.0047
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0019 0.0016
Echinococcus granulosus FTZ F1 alpha 0.001 0.0019 0.0016
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0019 0.0019
Echinococcus multilocularis ATP binding cassette sub family B 0.0022 0.0106 0.0104
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0112 0.6458
Schistosoma mansoni multidrug resistance protein 0.0022 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0089 0.0582 0.1251
Onchocerca volvulus 0.0009 0.0012 0.002
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0015 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0031 0.0168 0.0168
Schistosoma mansoni sodium/chloride dependent transporter 0.0089 0.0582 0.0582
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0019 0.0035
Onchocerca volvulus 0.0011 0.0025 0.0047
Onchocerca volvulus 0.0031 0.0167 0.0356
Onchocerca volvulus 0.0023 0.0112 0.0237

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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