Detailed information for compound 1528507

Basic information

Technical information
  • TDR Targets ID: 1528507
  • Name: 1-[2-(4-methylphenyl)-4-(4-methylphenyl)sulfo nyl-1,3-oxazol-5-yl]-4-phenylpiperazine
  • MW: 473.587 | Formula: C27H27N3O3S
  • H donors: 0 H acceptors: 3 LogP: 5.91 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)c1oc(c(n1)S(=O)(=O)c1ccc(cc1)C)N1CCN(CC1)c1ccccc1
  • InChi: 1S/C27H27N3O3S/c1-20-8-12-22(13-9-20)25-28-26(34(31,32)24-14-10-21(2)11-15-24)27(33-25)30-18-16-29(17-19-30)23-6-4-3-5-7-23/h3-15H,16-19H2,1-2H3
  • InChiKey: VPBBFLGBSCGPQR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-(4-methylphenyl)-4-(4-methylphenyl)sulfonyl-oxazol-5-yl]-4-phenyl-piperazine
  • 1-[2-(4-methylphenyl)-4-(4-methylphenyl)sulfonyl-5-oxazolyl]-4-phenylpiperazine
  • 1-[2-(4-methylphenyl)-4-(4-methylphenyl)sulfonyl-1,3-oxazol-5-yl]-4-phenyl-piperazine
  • D072-0718
  • NCGC00115675-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0189 0.0281
Echinococcus granulosus solute carrier family 22 0.0014 0.0094 0.0137
Trypanosoma cruzi ISWI complex protein 0.0018 0.0196 0.0292
Entamoeba histolytica protein kinase, putative 0.0031 0.0494 0.0634
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0189 0.0275
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0046
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Echinococcus granulosus zinc finger protein 0.0024 0.032 0.0466
Brugia malayi hypothetical protein 0.0016 0.013 0.0407
Trichomonas vaginalis DNA polymerase eta, putative 0.0037 0.0646 0.2979
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0293 0.3046
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0189 0.0872
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0503 0.0748
Loa Loa (eye worm) hypothetical protein 0.0033 0.0542 0.0789
Loa Loa (eye worm) hypothetical protein 0.0011 0.0028 0.0041
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.6731 1
Echinococcus multilocularis snurportin 1 0.0297 0.6865 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0337 0.0306
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0788 0.1129
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0494 0.0719
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0245 0.0357
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0247 0.036
Loa Loa (eye worm) hypothetical protein 0.0048 0.0906 0.132
Onchocerca volvulus 0.0014 0.0094 0.5
Onchocerca volvulus 0.0014 0.0094 0.5
Echinococcus granulosus dna polymerase kappa 0.0037 0.0646 0.0941
Onchocerca volvulus 0.0014 0.0094 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0137
Plasmodium vivax sugar transporter, putative 0.0014 0.0094 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.019 0.0875
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0265 0.0386
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0094 0.0245
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.1052 0.1563
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0031 0.0046
Echinococcus granulosus solute carrier family 22 0.0014 0.0094 0.0137
Echinococcus granulosus snurportin 1 0.0297 0.6865 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0494 0.0464
Echinococcus multilocularis General substrate transporter 0.0087 0.1829 0.2665
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0646 0.096
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0421 0.0625
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.1052 0.4852
Trypanosoma brucei ISWI complex protein 0.0018 0.0196 0.0292
Trypanosoma brucei glucose transporter, putative 0.0031 0.0503 0.0748
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0356 0.0326
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0119 0.0173
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0137
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0356 0.0519
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.1052 0.1524
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0094 0.014
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0212 0.0354
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0245 0.0372
Trypanosoma brucei DNA polymerase eta, putative 0.0062 0.1235 0.1834
Plasmodium vivax hexose transporter 0.0101 0.2169 0.2144
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0031 0.0046
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.012 0.0182
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0646 0.096
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0227 0.1047
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0405 0.0591
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.2169 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0103 0.0474
Schistosoma mansoni hypothetical protein 0.0018 0.0196 0.0286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0522 0.2408
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0035 0.0599 0.0911
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0031 0.0046
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.3056 0.4515
Trypanosoma cruzi hexose transporter 0.0031 0.0503 0.0748
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0189 0.0275
Plasmodium vivax CDK-related protein kinase 6, putative 0.0429 1 1
Brugia malayi hypothetical protein 0.0014 0.0094 0.0293
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0503 0.0748
Brugia malayi Flap endonuclease-1 0.0025 0.0356 0.1111
Plasmodium falciparum protein kinase 7 0.0285 0.6575 0.6564
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.012 0.0132
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.0479 0.0697
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0646 0.096
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0137
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0094 0.0094
Brugia malayi Importin beta-1 subunit 0.0028 0.0421 0.1312
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0479 0.0697
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0247 0.036
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0448 0.0653
Entamoeba histolytica Ran family GTPase 0.0021 0.0245 0.0314
Echinococcus multilocularis solute carrier family 22 0.0014 0.0094 0.0137
Onchocerca volvulus 0.0014 0.0094 0.5
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.0646 0.186
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0599 0.0847
Schistosoma mansoni flap endonuclease-1 0.0023 0.0298 0.0435
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.012 0.0178
Entamoeba histolytica protein kinase, putative 0.0031 0.0494 0.0634
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0212 0.0354
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.0503 0.0704
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0094 0.0434
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.0479 0.0577
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0094 0.0143
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0494 0.0464
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0293 0.0828
Plasmodium falciparum mitogen-activated protein kinase 2 0.0163 0.3655 0.3635
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0247 0.036
Plasmodium falciparum flap endonuclease 1 0.0025 0.0356 0.0326
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.1052 0.1533
Echinococcus multilocularis zinc finger protein 0.0024 0.032 0.0466
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0494 0.0464
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0862 0.3977
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0031 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0787 0.3627
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0503 0.2321
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.012 0.0178
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0119 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0031 0.0046
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.012 0.0076
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0503 0.2321
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.019 0.0236
Trypanosoma brucei glucose transporter 2A 0.0031 0.0503 0.0748
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.053 0.2444
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0369 0.0549
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0037 0.0646 0.0918
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.019 0.0276
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0137
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0293 0.0263
Loa Loa (eye worm) hypothetical protein 0.003 0.0479 0.0697
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0494 0.0719
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0646 0.096
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0189 1
Trypanosoma brucei glucose transporter, putative 0.0031 0.0503 0.0748
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0522 0.2408
Brugia malayi Bromodomain containing protein 0.0091 0.192 0.5991
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0494 0.0719
Leishmania major glucose transporter, lmgt1 0.0031 0.0503 0.0704
Loa Loa (eye worm) sugar transporter 0.0014 0.0094 0.0137
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.1052 0.1533
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.019 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0455 0.2099
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Loa Loa (eye worm) hypothetical protein 0.0021 0.0247 0.036
Toxoplasma gondii protein kinase, putative 0.0285 0.6575 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.012 0.0174
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0494 0.0464
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0421 0.0613
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2169 0.3159
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.019 0.0236
Onchocerca volvulus 0.0014 0.0094 0.5
Leishmania major hypothetical protein, conserved 0.0014 0.0094 0.0094
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0356 0.0542
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0494 0.0719
Schistosoma mansoni ran 0.0021 0.0245 0.0357
Loa Loa (eye worm) hypothetical protein 0.0144 0.3205 0.4669
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.6731 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2169 0.3159
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.1052 0.1563
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0295 0.0438
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0137
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0293 0.0391
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0503 0.2321
Onchocerca volvulus 0.0014 0.0094 0.5
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0245 0.0357
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.012 0.0174
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.1052 0.1533
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0163 0.3655 0.556
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0293 0.0446
Brugia malayi hypothetical protein 0.0024 0.0337 0.1051
Echinococcus granulosus GPCR family 2 0.0015 0.0119 0.0173
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0625 0.2882
Loa Loa (eye worm) hypothetical protein 0.0031 0.0494 0.0719
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0016 0.0023
Giardia lamblia DINP protein human, muc B family 0.0037 0.0646 0.0793
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0163 0.3655 0.3635
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.0646 0.186
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0189 0.059
Toxoplasma gondii exonuclease III APE 0.0018 0.0189 0.0287
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Loa Loa (eye worm) hypothetical protein 0.0062 0.1235 0.1798
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0787 0.3627
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0454 0.2094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.019 0.0875
Schistosoma mansoni zinc finger protein 0.0018 0.0196 0.0286
Echinococcus multilocularis muscleblind protein 0.0144 0.3205 0.4669
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.035 0.051
Echinococcus multilocularis muscleblind protein 1 0.0144 0.3205 0.4669
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.072 0.3319
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0646 0.1655
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0189 0.0281
Leishmania major GTP-binding protein, putative 0.0021 0.0245 0.0319
Schistosoma mansoni ap endonuclease 0.0018 0.0189 0.0275
Schistosoma mansoni hypothetical protein 0.0015 0.0119 0.0173
Schistosoma mansoni protein kinase 0.0031 0.0494 0.0719
Loa Loa (eye worm) hypothetical protein 0.0025 0.0343 0.05
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0735 0.1093
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Plasmodium vivax importin-beta 2, putative 0.0028 0.0421 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.072 0.3319
Toxoplasma gondii sugar transporter ST3 0.0014 0.0094 0.0143
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.1052 0.1352
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0792 0.1154
Giardia lamblia Hexose transporter 0.0014 0.0094 0.0081
Trichomonas vaginalis ran, putative 0.0021 0.0245 0.1129
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0503 0.2321
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0356 0.0457
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0094 0.0293
Trypanosoma brucei glucose transporter, putative 0.0031 0.0503 0.0748
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0189 0.0872
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0189 0.0243
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.019 0.0875
Schistosoma mansoni hypothetical protein 0.0015 0.0119 0.0173
Brugia malayi Bromodomain containing protein 0.0046 0.086 0.2685
Trypanosoma brucei sugar transporter, putative 0.0014 0.0094 0.014
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0494 0.0464
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0646 0.096
Echinococcus granulosus flap endonuclease 1 0.0025 0.0356 0.0519
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Loa Loa (eye worm) hypothetical protein 0.0015 0.0119 0.0173
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0189 1
Mycobacterium ulcerans hypothetical protein 0.0012 0.0031 0.0061
Schistosoma mansoni DNA polymerase eta 0.0062 0.1235 0.1798
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0494 0.0719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.019 0.0875
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0369 0.0549
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0337 0.05
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0094 0.014
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0405 0.0591
Leishmania major glucose transporter, lmgt3 0.0031 0.0503 0.0704
Schistosoma mansoni sugar transporter 0.0014 0.0094 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0028 0.0129
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.012 0.0174
Echinococcus multilocularis solute carrier family 22 0.0014 0.0094 0.0137
Schistosoma mansoni hypothetical protein 0.0025 0.035 0.051
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0503 0.2321
Schistosoma mansoni zinc finger protein 0.0024 0.032 0.0466
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0646 0.096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0455 0.2099
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0094 0.0434
Schistosoma mansoni importin beta-1 0.0028 0.0421 0.0613
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0503 0.2321
Onchocerca volvulus 0.0014 0.0094 0.5
Trypanosoma brucei unspecified product 0.0037 0.0646 0.096
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.062 0.0921
Loa Loa (eye worm) sugar transporter 0.0101 0.2169 0.3159
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0094 0.0434
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0494 0.0464
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.1478 0.2153
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0293 0.0436
Echinococcus multilocularis dna polymerase kappa 0.0037 0.0646 0.0941
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.0646 0.0941
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.072 0.3319
Brugia malayi major facilitator superfamily protein 0.0014 0.0094 0.0293
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0792 0.1154
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.012 0.0178
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0012 0.0052 0.0076
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0189 0.0285
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.019 0.0282
Echinococcus multilocularis GPCR, family 2 0.0015 0.0119 0.0173
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0295 0.1359
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0137
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.012 0.0089
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0646 0.096
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0646 0.096
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.0646 0.0941
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0735 0.1093
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.012 0.0174
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0293 0.0427
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0101 0.2169 0.3159
Schistosoma mansoni ap endonuclease 0.0018 0.0189 0.0275
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Schistosoma mansoni hypothetical protein 0.0011 0.0016 0.0023
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0011 0.0028 0.0043
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.012 0.0089
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Echinococcus granulosus solute carrier family 22 0.0014 0.0094 0.0137
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0119 0.0371
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0735 0.1093
Leishmania major hypothetical protein, conserved 0.0024 0.0337 0.0456
Onchocerca volvulus 0.0014 0.0094 0.5
Schistosoma mansoni hypothetical protein 0.0015 0.0119 0.0173
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0494 0.0464
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0494 0.0719
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0646 0.096
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.062 0.0943
Echinococcus granulosus solute carrier family 22 0.0014 0.0094 0.0137
Loa Loa (eye worm) hypothetical protein 0.003 0.0479 0.0697
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0906 0.2827
Brugia malayi major facilitator superfamily protein 0.0014 0.0094 0.0293
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0094 0.0137
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0646 0.096
Echinococcus granulosus muscleblind protein 0.0144 0.3205 0.4669
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.019 0.0282
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0494 0.0719
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0137
Plasmodium vivax proline--tRNA ligase, putative 0.0035 0.0599 0.0569
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0031 0.0046
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0119 0.0173
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0037 0.0646 0.0941
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0599 0.089
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0293 0.0915
Schistosoma mansoni glucose transporter 0.0014 0.0094 0.0137
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.3056 0.4541
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0031 0.0046
Trypanosoma brucei glucose transporter, putative 0.0031 0.0503 0.0748
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Schistosoma mansoni glucose transport protein 0.0101 0.2169 0.3159
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.1052 0.1533
Trypanosoma brucei unspecified product 0.0026 0.0369 0.0549
Giardia lamblia DNA repair protein RAD52 0.0336 0.7785 1
Schistosoma mansoni glucose transport protein 0.0101 0.2169 0.3159
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Brugia malayi hypothetical protein 0.0014 0.0094 0.0293
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0137
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0119 0.0371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0455 0.2099
Schistosoma mansoni protein kinase 0.0031 0.0494 0.0719
Trypanosoma brucei unspecified product 0.0026 0.0369 0.0549
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0494 0.0734
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0094 0.0434
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0094 0.0137
Leishmania major importin beta-1 subunit, putative 0.0023 0.0295 0.0393
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0247 0.036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0247 0.036
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0906 0.2827
Schistosoma mansoni hypothetical protein 0.0101 0.2169 0.3159
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0247 0.036
Leishmania major glucose transporter, lmgt2 0.0031 0.0503 0.0704
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0094 0.0245
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0094 0.0245
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.3429 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0356 0.1642
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0646 0.096
Toxoplasma gondii facilitative glucose transporter GT1 0.0101 0.2169 0.3298
Brugia malayi Sugar transporter family protein 0.0014 0.0094 0.0293
Loa Loa (eye worm) hypothetical protein 0.0024 0.0337 0.0491
Schistosoma mansoni sugar transporter 0.0014 0.0094 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0646 0.096
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.019 0.0592
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0646 0.096
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0293 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0787 0.3627
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0189 0.0203
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0137
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0356 0.0529
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0503 0.2321
Giardia lamblia Sugar-proton symporter 0.0014 0.0094 0.0081
Echinococcus granulosus dna polymerase eta 0.0062 0.1235 0.1798
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0189 0.0275
Onchocerca volvulus 0.0014 0.0094 0.5
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0494 0.0719
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0494 0.1541
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2169 0.3159
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Brugia malayi PHD-finger family protein 0.003 0.0474 0.1478
Onchocerca volvulus 0.0014 0.0094 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.072 0.3319
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0094 0.0434
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0031 0.0046
Onchocerca volvulus Putative transporter 0.0014 0.0094 0.5
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0189 0.0158
Brugia malayi Cam kinase protein 1 0.0031 0.0494 0.1541
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0369 0.0549
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0189 0.0235
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.6731 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.019 0.0282
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0094 0.0137
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.6865 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0494 0.0752
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0094 0.0293
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0599 0.0847
Leishmania major protein kinase, putative 0.0031 0.0494 0.069
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0189 0.0158
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0245 0.0364
Leishmania major hypothetical protein, conserved 0.0018 0.0196 0.0246
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0094 0.0137
Entamoeba histolytica hypothetical protein 0.0023 0.0295 0.0379
Loa Loa (eye worm) hypothetical protein 0.0052 0.0986 0.1436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0787 0.3627
Trypanosoma cruzi DNA polymerase eta, putative 0.0062 0.1235 0.1834
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.0479 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0031 0.0048
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0164 0.0243
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.019 0.0276
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0542 0.169
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0293 0.0427
Loa Loa (eye worm) hypothetical protein 0.0023 0.0293 0.0427
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0031 0.0046
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.012 0.0174
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.072 0.1095
Toxoplasma gondii hypothetical protein 0.0047 0.088 0.1338
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0094 0.0434
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2169 0.3159
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.0646 0.083
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0356 0.0519
Brugia malayi polk-prov protein 0.0012 0.0031 0.0098
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.3056 0.4541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0787 0.3627
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0494 0.0719
Onchocerca volvulus 0.0014 0.0094 0.5
Loa Loa (eye worm) hypothetical protein 0.0049 0.0931 0.1356
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.0479 0.1494
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0245 0.0214
Trypanosoma cruzi ISWI complex protein 0.0018 0.0196 0.0292
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0247 0.036
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0646 0.096
Trypanosoma brucei glucose transporter, putative 0.0031 0.0503 0.0748
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.1235 0.3852
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0137
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0356 0.0419
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0337 0.0306
Loa Loa (eye worm) hypothetical protein 0.0085 0.1797 0.2617
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0119 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0094 0.0434
Trypanosoma brucei glucose transporter, putative 0.0031 0.0503 0.0748
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0119 0.0173
Brugia malayi isocitrate dehydrogenase 0.0015 0.012 0.0373
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.0646 0.0941
Brugia malayi Sugar transporter family protein 0.0014 0.0094 0.0293
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.072 0.3319
Loa Loa (eye worm) hypothetical protein 0.0046 0.0862 0.1256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.019 0.0875
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0337 0.05
Giardia lamblia GTOR 0.0054 0.1052 0.1317
Onchocerca volvulus 0.0014 0.0094 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.072 0.3319
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0293 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0646 0.096
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0245 0.0357
Plasmodium falciparum importin beta, putative 0.0028 0.0421 0.0391
Trypanosoma brucei glucose transporter 1E 0.0031 0.0503 0.0748
Echinococcus granulosus importin subunit beta 1 0.0028 0.0421 0.0613
Schistosoma mansoni glucose transport protein 0.0101 0.2169 0.3159
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0247 0.036
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0494 0.0752
Entamoeba histolytica hypothetical protein 0.0096 0.2039 0.262
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.6731 1
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0336 0.7785 1
Onchocerca volvulus 0.0014 0.0094 0.5
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0096 0.2039 0.262
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.1478 0.2153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.1052 0.4852
Onchocerca volvulus 0.0014 0.0094 0.5
Schistosoma mansoni hypothetical protein 0.0015 0.0119 0.0173
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0094 0.0137
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.1052 0.1524
Schistosoma mansoni sugar transporter 0.0014 0.0094 0.0137
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0494 0.2277
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.0479 0.0615
Plasmodium falciparum proline--tRNA ligase 0.0035 0.0599 0.0569
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0094 0.014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0137
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0094 0.0137
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.012 0.0174
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0503 0.0748
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.1052 0.4852
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0503 0.0748
Leishmania major DNA polymerase kappa, putative 0.0037 0.0646 0.0918
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.012 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0597 0.2753
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0293 0.0427
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0031 0.0048
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0337 0.0512
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0293 0.1353
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0294 0.0436
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0037 0.0646 0.2979
Echinococcus granulosus General substrate transporter 0.0087 0.1829 0.2665
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0599 0.089
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0503 0.0748
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0368 0.0547
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.012 0.0182
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.0479 0.1494
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0448 0.0653
Brugia malayi Sugar transporter family protein 0.0101 0.2169 0.6766
Schistosoma mansoni hypothetical protein 0.0297 0.6865 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0245 0.0275
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0245 0.0364
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0788 0.117
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0189 0.0281
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0788 0.117
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0031 0.0046
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0016 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0646 0.096
Echinococcus multilocularis solute carrier family 22 0.0014 0.0094 0.0137
Plasmodium falciparum hexose transporter 0.0101 0.2169 0.2144
Echinococcus multilocularis dna polymerase eta 0.0062 0.1235 0.1798
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0293 0.0338
Echinococcus multilocularis solute carrier family 22 0.0014 0.0094 0.0137
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2169 0.3159
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0646 0.096
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0245 0.0214
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.012 0.0174
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0479 0.0697
Loa Loa (eye worm) hypothetical protein 0.0144 0.3205 0.4669
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.1052 0.1352
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0293 0.0436
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0906 0.132
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0031 0.0046
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0245 0.0364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0455 0.2099
Entamoeba histolytica hypothetical protein 0.0023 0.0293 0.0377
Schistosoma mansoni protein kinase 0.0031 0.0494 0.0719
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2169 0.3159
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.0479 0.0697
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.0646 0.0941
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.1052 0.1563
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0094 0.0137
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0293 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0037 0.0646 0.1655
Toxoplasma gondii sugar transporter ST1 0.0014 0.0094 0.0143
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0245 0.0764
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0646 0.2016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0028
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2169 0.3159
Leishmania major DNA polymerase eta, putative 0.0062 0.1235 0.1796
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0494 0.0464
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.0479 0.2208
Onchocerca volvulus 0.0014 0.0094 0.5
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0356 0.0485
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Schistosoma mansoni sugar transporter 0.0014 0.0094 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0094 0.0434
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0094 0.0063
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0356 0.0529
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0494 0.0464
Schistosoma mansoni bromodomain containing protein 0.0076 0.1582 0.2304
Loa Loa (eye worm) hypothetical protein 0.0028 0.0421 0.0613
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0094 0.014
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0421 0.064
Schistosoma mansoni hypothetical protein 0.0033 0.0542 0.0789
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.053 0.2444
Schistosoma mansoni ran 0.0021 0.0245 0.0357
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0494 0.0752
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.095 0.1412
Brugia malayi Muscleblind-like protein 0.0144 0.3205 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.019 0.0282
Brugia malayi RNA, U transporter 1 0.0079 0.1649 0.5144
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.012 0.0178
Toxoplasma gondii sugar transporter ST2 0.0014 0.0094 0.0143
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0494 0.0719
Onchocerca volvulus 0.0014 0.0094 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.072 0.3319
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0337 0.05
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0189 0.0522
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0295 0.1359
Brugia malayi Isocitrate dehydrogenase 0.0015 0.012 0.0373
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0295 0.1359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0454 0.2094
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0494 0.0719
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.1052 0.1563
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0421 0.0625
Leishmania major DNA polymerase eta, putative 0.0036 0.062 0.0878
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0293 0.0828
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0454 0.2094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.053 0.2444
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0094 0.0293
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0503 0.0748
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Trypanosoma brucei glucose transporter, putative 0.0031 0.0503 0.0748
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0735 0.1093
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0405 0.0591
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0094 0.0434
Trypanosoma brucei glucose transporter, putative 0.0031 0.0503 0.0748
Brugia malayi hypothetical protein 0.0014 0.0094 0.0293
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0599 0.089
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0031 0.0046
Mycobacterium ulcerans sugar transporter 0.0014 0.0094 0.0245
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.1052 0.3283
Mycobacterium ulcerans hypothetical protein 0.0154 0.3429 1
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0337 0.0306
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.019 0.0276

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 5.8479 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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