Detailed information for compound 1528737

Basic information

Technical information
  • TDR Targets ID: 1528737
  • Name: N-(4-methyl-3-morpholin-4-ylsulfonylphenyl)-4 -propan-2-ylbenzenesulfonamide
  • MW: 438.561 | Formula: C20H26N2O5S2
  • H donors: 1 H acceptors: 4 LogP: 2.71 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1S(=O)(=O)N1CCOCC1)NS(=O)(=O)c1ccc(cc1)C(C)C
  • InChi: 1S/C20H26N2O5S2/c1-15(2)17-5-8-19(9-6-17)28(23,24)21-18-7-4-16(3)20(14-18)29(25,26)22-10-12-27-13-11-22/h4-9,14-15,21H,10-13H2,1-3H3
  • InChiKey: ASXNWLHDNRTZIG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-isopropyl-N-(4-methyl-3-morpholinosulfonyl-phenyl)benzenesulfonamide
  • 4-isopropyl-N-(4-methyl-3-morpholinosulfonylphenyl)benzenesulfonamide
  • N-(4-methyl-3-morpholin-4-ylsulfonyl-phenyl)-4-propan-2-yl-benzenesulfonamide
  • T5268442

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0127 0.0532
Echinococcus granulosus peptide allatostatin:somatostatin 0.0007 0.0014 0.0007
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0122 0.119 0.7832
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Onchocerca volvulus 0.0023 0.0176 0.0726
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0007 0.0014 0.0008
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0136 0.0632
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0041 0.0159
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0363 0.1766
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0007 0.0014 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0014 0.0008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0243 0.1165
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0024 0.019 0.0903
Schistosoma mansoni opsin-like receptor 0.0007 0.0014 0.0008
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0362 0.1203
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0176 0.5587
Echinococcus granulosus receptor type guanylyl cyclase 0.0024 0.019 0.0264
Echinococcus multilocularis g-protein coupled receptor 0.0007 0.0014 0.0005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.004 0.003
Echinococcus granulosus tm gpcr rhodopsin 0.0007 0.0014 0.0007
Echinococcus multilocularis somatostatin receptor 0.0007 0.0014 0.0005
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0116 0.0707
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0362 0.1203
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0127 0.3952
Loa Loa (eye worm) hypothetical protein 0.0024 0.019 0.0903
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0107 0.0702
Schistosoma mansoni neuropeptide F-like receptor 0.0007 0.0014 0.0008
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0185 0.1844 0.268
Onchocerca volvulus 0.0028 0.0226 0.0944
Brugia malayi neuropeptide F receptor 0.0007 0.0014 0.0024
Loa Loa (eye worm) G-protein coupled receptor 0.0007 0.0014 0.0024
Echinococcus multilocularis neuropeptide Y receptor 0.0007 0.0014 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0014 0.0008
Onchocerca volvulus 0.0007 0.0014 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0243 0.0399
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1359 0.4608
Onchocerca volvulus 0.0007 0.0014 0.0021
Brugia malayi Glutamate receptor 2 precursor 0.0047 0.0428 0.2089
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0022 0.0013
Loa Loa (eye worm) histone methyltransferase 0.001 0.004 0.015
Brugia malayi hypothetical protein 0.0007 0.0014 0.0024
Echinococcus multilocularis glutamate receptor NMDA 0.0504 0.5116 0.5112
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0047 0.0428 0.0419
Brugia malayi Melatonin receptor type 1A 0.0007 0.0014 0.0024
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0176 0.1101
Toxoplasma gondii exonuclease III APE 0.0018 0.0127 0.244
Echinococcus granulosus somatostatin receptor 0.0007 0.0014 0.0007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0007 0.0014 0.0005
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0007 0.0014 0.0008
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0559 0.2743
Echinococcus multilocularis GPCR, family 2 0.0019 0.0136 0.0127
Brugia malayi hypothetical protein 0.0007 0.0014 0.0024
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0041 0.0108
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0014 0.0008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0243 0.0234
Schistosoma mansoni hypothetical protein 0.0395 0.4 0.6828
Schistosoma mansoni hypothetical protein 0.0007 0.0014 0.0008
Onchocerca volvulus 0.0007 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Brugia malayi hypothetical protein 0.0024 0.019 0.0903
Loa Loa (eye worm) RGC/RGC protein kinase 0.0024 0.019 0.0903
Brugia malayi Dopamine receptor protein 2 0.0007 0.0014 0.0024
Echinococcus granulosus metabotropic glutamate receptor 2 0.0024 0.019 0.0264
Loa Loa (eye worm) hypothetical protein 0.0023 0.0176 0.083
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0176 0.6416
Brugia malayi sulfakinin receptor protein 0.0007 0.0014 0.0024
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0264 0.5284
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0047 0.0428 0.0419
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0014 0.0008
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0041 0.0032
Brugia malayi Inositol-1 0.0036 0.0307 0.1485
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0014 0.0008
Echinococcus granulosus glutamate receptor NMDA 0.0504 0.5116 0.7462
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0176 0.0568
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0269 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0394 0.0562
Echinococcus multilocularis orexin receptor type 2 0.0007 0.0014 0.0005
Echinococcus granulosus fmrfamide receptor 0.0007 0.0014 0.0007
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.2938 1
Chlamydia trachomatis glutamine binding protein 0.0122 0.119 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0014 0.0008
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0307 0.0298
Trichomonas vaginalis rotamase, putative 0.0032 0.0272 0.1164
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0007 0.0014 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0176 0.1101
Echinococcus multilocularis fmrfamide receptor 0.0007 0.0014 0.0005
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0127 0.0401
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0127 0.0172
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Mycobacterium ulcerans hypothetical protein 0.0023 0.0176 0.1101
Loa Loa (eye worm) hypothetical protein 0.0023 0.0176 0.083
Brugia malayi Pre-SET motif family protein 0.0029 0.0243 0.1165
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0414 0.0692
Schistosoma mansoni glutamate receptor kainate 0.0047 0.0428 0.0716
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0414 0.2019
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0072 0.0678 0.0669
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0394 0.1922
Loa Loa (eye worm) glutamate receptor 2 0.0047 0.0428 0.2089
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0127 0.0587
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0072 0.0678 0.0669
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0024 0.019 0.0903
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0041 0.0108
Echinococcus granulosus neuropeptide Y receptor 0.0007 0.0014 0.0007
Schistosoma mansoni glutamate receptor kainate 0.0047 0.0428 0.0716
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0014 0.0005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0127 0.0401
Schistosoma mansoni myosin xvIII 0.0007 0.0014 0.0008
Schistosoma mansoni ap endonuclease 0.0018 0.0127 0.0201
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0176 0.1101
Schistosoma mansoni amine GPCR 0.0007 0.0014 0.0008
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0014 0.0008
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0007 0.0014 0.0024
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0307 0.1317
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0007 0.0014 0.0024
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0176 0.083
Brugia malayi G protein-coupled receptor F59B2.13 0.0007 0.0014 0.0024
Schistosoma mansoni histamine h1 receptor 0.0007 0.0014 0.0008
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.1359 0.4608
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0307 1
Echinococcus granulosus allatostatin A receptor 0.0007 0.0014 0.0007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2012 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0007 0.0014 0.0008
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0264 0.0869
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0127 0.5037
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0264 0.0869
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0007 0.0014 0.0005
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0264 0.0869
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0136 0.0632
Echinococcus multilocularis neuropeptide receptor 0.0007 0.0014 0.0005
Schistosoma mansoni hypothetical protein 0.0007 0.0014 0.0008
Leishmania major extracellular receptor, putative 0.0024 0.019 0.0617
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0007 0.0014 0.0005
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0176 0.0568
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Echinococcus multilocularis dro:myosuppressin receptor 0.0007 0.0014 0.0005
Echinococcus multilocularis nmda type glutamate receptor 0.0673 0.6853 0.685
Echinococcus multilocularis smad 0.001 0.0041 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0014 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0014 0.0007
Echinococcus granulosus nmda type glutamate receptor 0.0673 0.6853 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0176 0.083
Schistosoma mansoni biogenic amine receptor 0.0007 0.0014 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0014 0.0008
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0269 0.1768
Onchocerca volvulus 0.0007 0.0014 0.0021
Schistosoma mansoni hypothetical protein 0.0047 0.0428 0.0716
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Echinococcus multilocularis serotonin receptor 0.0007 0.0014 0.0005
Brugia malayi larval opioid receptor 0.0007 0.0014 0.0024
Onchocerca volvulus 0.0007 0.0014 0.0021
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0007 0.0014 0.0008
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Echinococcus multilocularis fmrfamide receptor 0.0007 0.0014 0.0005
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0362 0.1203
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0007 0.0014 0.0008
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0072 0.0678 0.0976
Schistosoma mansoni hypothetical protein 0.0019 0.0136 0.0217
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0127 0.0532
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0307 0.1016
Brugia malayi G-protein coupled receptor 0.0007 0.0014 0.0024
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.2938 1
Brugia malayi mbt repeat family protein 0.0046 0.0414 0.2019
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0176 0.1101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0014 0.0008
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0022 0.0018
Mycobacterium ulcerans hypothetical protein 0.0154 0.1519 1
Schistosoma mansoni smad1 5 8 and 0.001 0.0041 0.0054
Echinococcus granulosus neuropeptide s receptor 0.0007 0.0014 0.0007
Echinococcus granulosus g-protein coupled receptor 0.0007 0.0014 0.0007
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0176 0.5587
Schistosoma mansoni inositol monophosphatase 0.0036 0.0307 0.0509
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0007 0.0014 0.0024
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.0272 0.131
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0007 0.0014 0.0008
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0243 0.0234
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0022 0.0013
Schistosoma mansoni cpg binding protein 0.0029 0.0242 0.0397
Brugia malayi Metabotropic glutamate receptor precursor. 0.0024 0.019 0.0903
Trypanosoma cruzi extracellular receptor, putative 0.0024 0.019 0.0617
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0127 0.323
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0007 0.0014 0.0005
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Echinococcus granulosus metabotropic glutamate receptor 5 0.0024 0.019 0.0264
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Schistosoma mansoni neuropeptide F-like receptor 0.0007 0.0014 0.0008
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.001 0.0063
Echinococcus granulosus smad 0.001 0.0041 0.0047
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0127 0.0401
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0127 0.0837
Schistosoma mansoni hypothetical protein 0.0019 0.0136 0.0217
Brugia malayi G protein-coupled receptor 0.0007 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Schistosoma mansoni tyrosine kinase 0.0024 0.019 0.0309
Onchocerca volvulus 0.0007 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Schistosoma mansoni hypothetical protein 0.0041 0.0363 0.0605
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0014 0.0008
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0559 0.2743
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0116 0.9078
Onchocerca volvulus 0.0007 0.0014 0.0021
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0041 0.0032
Schistosoma mansoni hypothetical protein 0.0019 0.0136 0.0217
Brugia malayi hypothetical protein 0.0007 0.0014 0.0024
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0007 0.0014 0.0005
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0007 0.0014 0.0024
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0007 0.0014 0.0024
Echinococcus multilocularis neuropeptides capa receptor 0.0007 0.0014 0.0005
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0007 0.0014 0.0005
Schistosoma mansoni cpg binding protein 0.0029 0.0242 0.0397
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0122 0.119 1
Brugia malayi ORL1-like opioid receptor 0.0007 0.0014 0.0024
Echinococcus granulosus tm gpcr rhodopsin 0.0007 0.0014 0.0007
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0007 0.0014 0.0007
Schistosoma mansoni opsin-like receptor 0.0007 0.0014 0.0008
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Schistosoma mansoni biogenic amine (5HT) receptor 0.0007 0.0014 0.0008
Schistosoma mansoni ap endonuclease 0.0018 0.0127 0.0201
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0007 0.0014 0.0005
Brugia malayi Tachykinin-like peptides receptor 99D 0.0007 0.0014 0.0024
Schistosoma mansoni neuropeptide f receptor 76f 0.0007 0.0014 0.0008
Schistosoma mansoni protein kinase 0.0024 0.019 0.0309
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0176 0.0568
Brugia malayi Pre-SET motif family protein 0.0202 0.2012 1
Schistosoma mansoni amine GPCR 0.0007 0.0014 0.0008
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0038 0.0144
Loa Loa (eye worm) hypothetical protein 0.0024 0.019 0.0903
Loa Loa (eye worm) neuropeptide F receptor 0.0007 0.0014 0.0024
Echinococcus multilocularis tyrosine kinase 0.0024 0.019 0.0181
Onchocerca volvulus 0.0029 0.0243 0.102
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0007 0.0014 0.0024
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0414 0.0405
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0007 0.0014 0.0005
Schistosoma mansoni amine GPCR 0.0007 0.0014 0.0008
Echinococcus granulosus neuropeptides capa receptor 0.0007 0.0014 0.0007
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0007 0.0014 0.0024
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0007 0.0014 0.0005
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0041 0.0047
Echinococcus granulosus alpha 1A adrenergic receptor 0.0007 0.0014 0.0007
Schistosoma mansoni opsin-like receptor 0.0007 0.0014 0.0008
Echinococcus multilocularis g protein coupled receptor 0.0007 0.0014 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0014 0.0007
Schistosoma mansoni amine GPCR 0.0007 0.0014 0.0008
Echinococcus multilocularis allatostatin A receptor 0.0007 0.0014 0.0005
Schistosoma mansoni amine GPCR 0.0007 0.0014 0.0008
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0041 0.0159
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0007 0.0014 0.0008
Onchocerca volvulus 0.0007 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Brugia malayi hypothetical protein 0.0007 0.0014 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0107 0.0702
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0136 0.0185
Brugia malayi hypothetical protein 0.0007 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Brugia malayi hypothetical protein 0.0007 0.0014 0.0024
Echinococcus granulosus neuropeptide Y receptor 0.0007 0.0014 0.0007
Loa Loa (eye worm) Smad1 0.001 0.0041 0.0159
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0362 0.1203
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Plasmodium vivax SET domain protein, putative 0.0029 0.0243 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0007 0.0014 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0014 0.0008
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Brugia malayi Guanylyl cyclase protein 23 0.0024 0.019 0.0903
Echinococcus granulosus G protein coupled receptor 139 0.0007 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0072 0.0678 0.0976
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0014 0.0007
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0414 0.0591
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0127 0.0118
Echinococcus multilocularis g protein coupled receptor 0.0007 0.0014 0.0005
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0307 0.0435
Echinococcus granulosus cpg binding protein 0.0029 0.0242 0.0339
Brugia malayi neuropeptide F receptor 0.0007 0.0014 0.0024
Schistosoma mansoni glutamate receptor NMDA 0.0576 0.5854 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0007 0.0014 0.0024
Onchocerca volvulus 0.0007 0.0014 0.0021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0394 0.0659
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0041 0.0658
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1422 0.705
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0072 0.0678 0.0669
Brugia malayi mbt repeat family protein 0.0046 0.0414 0.2019
Echinococcus multilocularis neuropeptide Y receptor 0.0007 0.0014 0.0005
Echinococcus multilocularis sex peptide receptor 0.0007 0.0014 0.0005
Loa Loa (eye worm) G-protein coupled receptor 0.0007 0.0014 0.0024
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0116 0.4573
Loa Loa (eye worm) hypothetical protein 0.0024 0.019 0.0903
Echinococcus granulosus expressed protein 0.0032 0.0272 0.0383
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0176 0.6416
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.001 0.0063
Brugia malayi hypothetical protein 0.0007 0.0014 0.0024
Echinococcus granulosus dnaJ subfamily B 0.0395 0.4 0.5831
Echinococcus granulosus serotonin receptor 0.0007 0.0014 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0107 0.0702
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0122 0.119 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0394 0.0659
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0014 0.0007
Echinococcus granulosus tyrosine kinase 0.0024 0.019 0.0264
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0414 0.0591
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0127 0.0401
Loa Loa (eye worm) RGC/RGC protein kinase 0.0024 0.019 0.0903
Echinococcus granulosus histone acetyltransferase MYST2 0.0052 0.0479 0.0687
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0556 0.0935
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0014 0.0005
Schistosoma mansoni glutamate receptor AMPA 0.0047 0.0428 0.0716
Echinococcus multilocularis cpg binding protein 0.0029 0.0242 0.0232
Echinococcus granulosus tachykinin peptides receptor 99D 0.0007 0.0014 0.0007
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0024 0.019 0.0903
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0007 0.0014 0.0005
Loa Loa (eye worm) inositol-1 0.0036 0.0307 0.1485
Echinococcus granulosus glutamate NMDA receptor subunit 0.0047 0.0428 0.0611
Echinococcus granulosus g protein coupled receptor 0.0007 0.0014 0.0007
Onchocerca volvulus 0.0229 0.2298 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0176 0.1101
Brugia malayi Smad1 0.001 0.0041 0.0159
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0022 0.0018
Schistosoma mansoni glutamate receptor AMPA 0.0047 0.0428 0.0716
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0176 0.5587
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0047 0.0428 0.0611
Echinococcus multilocularis expressed protein 0.0032 0.0272 0.0263
Echinococcus granulosus biogenic amine 5HT receptor 0.0007 0.0014 0.0007
Brugia malayi follicle stimulating hormone receptor 0.0007 0.0014 0.0024
Onchocerca volvulus 0.0007 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.006 0.0559 0.2743
Echinococcus granulosus orexin receptor type 2 0.0007 0.0014 0.0007
Echinococcus granulosus glutamate receptor subunit protein glur 0.0047 0.0428 0.0611
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0024 0.019 0.0903
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.2938 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0414 0.1767
Loa Loa (eye worm) hypothetical protein 0.0046 0.0414 0.2019
Loa Loa (eye worm) neuropeptide F receptor 0.0007 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Onchocerca volvulus 0.0024 0.019 0.079
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0394 0.0385
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0007 0.0014 0.0024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0014 0.0005
Echinococcus granulosus 7tm_1 domain containing protein 0.0007 0.0014 0.0007
Schistosoma mansoni neuropeptide receptor 0.0007 0.0014 0.0008
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0052 0.0479 0.2346
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0176 0.083
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0014 0.0005
Schistosoma mansoni metabotropic glutamate receptor 0.0024 0.019 0.0309
Trichomonas vaginalis set domain proteins, putative 0.0229 0.2298 1
Echinococcus granulosus atrial natriuretic peptide receptor 0.0024 0.019 0.0264
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0041 0.0047
Schistosoma mansoni rotamase 0.0032 0.0272 0.0449
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0226 0.1078
Schistosoma mansoni biogenic amine receptor 0.0007 0.0014 0.0008
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Echinococcus multilocularis glutamate receptor 2 0.0047 0.0428 0.0419
Schistosoma mansoni glutamate receptor NMDA 0.0047 0.0428 0.0716
Loa Loa (eye worm) hypothetical protein 0.0017 0.0116 0.0533
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0264 0.8558
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0394 0.1922
Schistosoma mansoni smad1 5 8 and 0.001 0.0041 0.0054
Brugia malayi Dopamine receptor 0.0007 0.0014 0.0024
Loa Loa (eye worm) TYRA-2 protein 0.0007 0.0014 0.0024
Echinococcus granulosus GPCR family 2 0.0019 0.0136 0.0185
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.4 0.3994
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0007 0.0014 0.0008
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0007 0.0014 0.0007
Echinococcus multilocularis histone acetyltransferase MYST2 0.0052 0.0479 0.047
Schistosoma mansoni biogenic amine receptor 0.0007 0.0014 0.0008
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0169 0.1677 0.1669
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0007 0.0014 0.0007
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0136 0.0127
Loa Loa (eye worm) hypothetical protein 0.0023 0.0176 0.083
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0007 0.0014 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0014 0.0007
Loa Loa (eye worm) RGC/RGC protein kinase 0.0024 0.019 0.0903
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0243 0.0341
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0052 0.0479 0.0687
Toxoplasma gondii hypothetical protein 0.0047 0.0424 0.86
Echinococcus granulosus g protein coupled receptor 0.0007 0.0014 0.0007
Echinococcus granulosus neuropeptides capa receptor 0.0007 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0052 0.0479 0.2346
Echinococcus granulosus dro:myosuppressin receptor 0.0007 0.0014 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0107 0.0702
Echinococcus granulosus g protein coupled receptor 0.0007 0.0014 0.0007
Echinococcus multilocularis glutamate receptor 2 0.0024 0.019 0.0181
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0072 0.0678 0.0976
Loa Loa (eye worm) hypothetical protein 0.0041 0.0363 0.1766
Loa Loa (eye worm) hypothetical protein 0.0024 0.019 0.0903
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.001 0.0063
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0007 0.0014 0.0007
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0226 0.0316
Echinococcus multilocularis G protein coupled receptor 139 0.0007 0.0014 0.0005
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Brugia malayi AKH receptor 0.0007 0.0014 0.0024
Echinococcus multilocularis NMDA receptor 0.0047 0.0428 0.0419
Loa Loa (eye worm) hypothetical protein 0.0024 0.019 0.0903
Loa Loa (eye worm) hypothetical protein 0.0017 0.0116 0.0533
Onchocerca volvulus 0.0024 0.019 0.079
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0414 0.0692
Loa Loa (eye worm) MBCTL1 0.0052 0.0479 0.2346
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Echinococcus multilocularis glutamate receptor 2 0.0072 0.0678 0.0669
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0136 0.0632
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Brugia malayi Receptor family ligand binding region containing protein 0.0024 0.019 0.0903
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1359 0.4608
Brugia malayi MH2 domain containing protein 0.001 0.0041 0.0159
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Brugia malayi putative neuropeptide receptor NPR1 0.0007 0.0014 0.0024
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0176 0.1101
Echinococcus multilocularis neuropeptides capa receptor 0.0007 0.0014 0.0005
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0307 0.1016
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Echinococcus multilocularis Smad4 0.001 0.0041 0.0032
Schistosoma mansoni glutamate receptor kainate 0.0047 0.0428 0.0716
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0176 0.1157
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0394 0.0385
Brugia malayi Serotonin receptor 0.0007 0.0014 0.0024
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0136 0.0185
Onchocerca volvulus 0.0007 0.0014 0.0021
Echinococcus multilocularis G-protein coupled receptor, putative 0.0007 0.0014 0.0005
Schistosoma mansoni myelin transcription factor 1 myt1 0.0052 0.0479 0.0804
Schistosoma mansoni neuropeptide receptor 0.0007 0.0014 0.0008
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Brugia malayi Glutamate receptor 1 precursor 0.0047 0.0428 0.2089
Echinococcus granulosus glutamate receptor 2 0.0024 0.019 0.0264
Brugia malayi MH1 domain containing protein 0.001 0.0041 0.0159
Echinococcus multilocularis neuropeptide receptor A26 0.0007 0.0014 0.0005
Echinococcus granulosus 7TM GPCR rhodopsin 0.0007 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0024 0.019 0.0903
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0264 0.0869
Echinococcus granulosus neuropeptide receptor 0.0007 0.0014 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0014 0.0005
Onchocerca volvulus 0.0007 0.0014 0.0021
Loa Loa (eye worm) melatonin receptor type 1A 0.0007 0.0014 0.0024
Schistosoma mansoni cpg binding protein 0.0028 0.0226 0.0369
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0116 0.0766
Loa Loa (eye worm) hypothetical protein 0.0017 0.0116 0.0533
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.001 0.0063
Schistosoma mansoni adenoreceptor 0.0007 0.0014 0.0008
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0307 0.1016
Trichomonas vaginalis rotamase, putative 0.0032 0.0264 0.113
Loa Loa (eye worm) glutamate receptor 0.0024 0.019 0.0903
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.001 0.002
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.001 0.0063
Schistosoma mansoni neuropeptide receptor 0.0007 0.0014 0.0008
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0047 0.0428 0.0611
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0047 0.0428 0.0419
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0243 0.0399
Schistosoma mansoni hypothetical protein 0.0007 0.0014 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0014 0.0005
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.001 0.0063
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0024 0.019 0.079
Schistosoma mansoni alpha-1 adrenergic receptor 0.0007 0.0014 0.0008
Schistosoma mansoni ATP-binding cassette transporter 0.0047 0.0428 0.0716
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0559 0.2743
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1422 0.705
Onchocerca volvulus 0.0007 0.0014 0.0021
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0007 0.0014 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0014 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0243 0.0399
Brugia malayi Serotonin receptor 0.0007 0.0014 0.0024
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0127 0.0779
Onchocerca volvulus 0.0007 0.0014 0.0021
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0041 0.0108
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.001 0.0063
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0007 0.0014 0.0005
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0024 0.019 0.0181
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.001 0.0063
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Echinococcus multilocularis serotonin receptor 0.0007 0.0014 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0014 0.0007
Echinococcus multilocularis neuropeptide s receptor 0.0007 0.0014 0.0005
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0307 1
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0047 0.0428 0.0611
Echinococcus multilocularis g protein coupled receptor 0.0007 0.0014 0.0005
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.2938 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0307 0.6174
Loa Loa (eye worm) hypothetical protein 0.0017 0.0116 0.0533
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Brugia malayi Receptor family ligand binding region containing protein 0.0024 0.019 0.0903
Entamoeba histolytica hypothetical protein 0.0024 0.019 0.6077
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0007 0.0014 0.0008
Echinococcus granulosus hypothetical protein 0.0007 0.0014 0.0007
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0072 0.0678 0.0976
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0032 0.0272 0.131
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0022 0.0022
Brugia malayi Dopamine receptor protein 1 0.0007 0.0014 0.0024
Schistosoma mansoni smad1 5 8 and 0.001 0.0041 0.0054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0394 0.0562
Brugia malayi G-protein coupled receptor 0.0007 0.0014 0.0024
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0047 0.0428 0.0419
Onchocerca volvulus 0.0007 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0024 0.019 0.0903
Brugia malayi metabotropic glutamate receptor type 2 0.0024 0.019 0.0903
Loa Loa (eye worm) hypothetical protein 0.0017 0.0116 0.0533
Echinococcus granulosus neuropeptide receptor 0.0007 0.0014 0.0007
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0041 0.0108
Schistosoma mansoni hypothetical protein 0.0007 0.0014 0.0008
Echinococcus multilocularis neuropeptide receptor 0.0007 0.0014 0.0005
Echinococcus granulosus tm gpcr rhodopsin 0.0007 0.0014 0.0007
Brugia malayi hypothetical protein 0.0007 0.0014 0.0024
Echinococcus granulosus nmda type glutamate receptor 0.0528 0.5366 0.7827
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0394 0.0659
Onchocerca volvulus 0.0007 0.0014 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0014 0.0007
Schistosoma mansoni hypothetical protein 0.0019 0.0136 0.0217
Echinococcus granulosus biogenic amine 5HT receptor 0.0007 0.0014 0.0007
Brugia malayi MH1 domain containing protein 0.001 0.0041 0.0159
Onchocerca volvulus Neuropeptide F receptor homolog 0.0007 0.0014 0.0021
Loa Loa (eye worm) glutamate receptor 1 0.0047 0.0428 0.2089
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0122 0.119 0.7818
Brugia malayi putative neuropeptide receptor 0.0007 0.0014 0.0024
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0414 0.0692
Brugia malayi hypothetical protein 0.0007 0.0014 0.0024
Onchocerca volvulus 0.0007 0.0014 0.0021
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0052 0.0479 0.047
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.004 0.0044
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0024 0.019 0.0181
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0491 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0176 0.1101
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0307 0.197
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Echinococcus granulosus sex peptide receptor 0.0007 0.0014 0.0007
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0007 0.0014 0.0005
Echinococcus granulosus neuropeptide FF receptor 2 0.0007 0.0014 0.0007
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0136 0.0127
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0014 0.0005
Brugia malayi GnHR receptor homolog 0.0007 0.0014 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0243 0.0399
Schistosoma mansoni inositol monophosphatase 0.0036 0.0307 0.0509
Loa Loa (eye worm) hypothetical protein 0.0024 0.019 0.0903
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.001 0.0063
Brugia malayi MH2 domain containing protein 0.0144 0.1422 0.705
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0307 0.1016
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.001 0.002
Schistosoma mansoni tyrosine kinase 0.0024 0.019 0.0309
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0176 0.1157
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.001 0.0063
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.001 0.0063
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0122 0.119 1
Onchocerca volvulus 0.0046 0.0414 0.1767
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0632
Brugia malayi hypothetical protein 0.0007 0.0014 0.0024
Schistosoma mansoni Smad4 0.001 0.0041 0.0054
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0127 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0007 0.0014 0.0008
Echinococcus granulosus glutamate receptor 2 0.0072 0.0678 0.0976
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Brugia malayi CXXC zinc finger family protein 0.0028 0.0226 0.1078
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0243 0.4844
Brugia malayi RE15519p 0.0007 0.0014 0.0024
Echinococcus multilocularis receptor type guanylyl cyclase 0.0024 0.019 0.0181
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0024
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0454 0.1518
Schistosoma mansoni smad 0.001 0.0041 0.0054
Echinococcus granulosus neuropeptide receptor A26 0.0007 0.0014 0.0007
Echinococcus granulosus Smad4 0.001 0.0041 0.0047
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0414 0.0405
Schistosoma mansoni biogenic amine (5HT) receptor 0.0007 0.0014 0.0008
Schistosoma mansoni neuropeptide receptor 0.0007 0.0014 0.0008
Echinococcus multilocularis nmda type glutamate receptor 0.0528 0.5366 0.5362
Brugia malayi MH2 domain containing protein 0.001 0.0041 0.0159
Echinococcus multilocularis neuropeptide FF receptor 2 0.0007 0.0014 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0272 0.1164
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0127 0.0587
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0041 0.0054
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0007 0.0014 0.0024
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0185 0.1844 0.1836
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0024 0.019 0.0181
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0307 0.1317
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0072 0.0678 0.0669
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0127 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.019 0.0903
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0307 0.1317
Schistosoma mansoni hypothetical protein 0.0284 0.2856 0.4871
Schistosoma mansoni metabotropic glutamate receptor 0.0024 0.019 0.0309
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0007 0.0014 0.0005
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1519 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.609 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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