Detailed information for compound 1544238

Basic information

Technical information
  • TDR Targets ID: 1544238
  • Name: N-(3,4-dimethylphenyl)-N-(1-morpholin-4-yl-1- oxopropan-2-yl)methanesulfonamide
  • MW: 340.438 | Formula: C16H24N2O4S
  • H donors: 0 H acceptors: 3 LogP: 1.36 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(N(S(=O)(=O)C)c1ccc(c(c1)C)C)C)N1CCOCC1
  • InChi: 1S/C16H24N2O4S/c1-12-5-6-15(11-13(12)2)18(23(4,20)21)14(3)16(19)17-7-9-22-10-8-17/h5-6,11,14H,7-10H2,1-4H3
  • InChiKey: NANNWEXNZOCELE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3,4-dimethylphenyl)-N-(1-methyl-2-morpholino-2-oxo-ethyl)methanesulfonamide
  • N-(3,4-dimethylphenyl)-N-(1-methyl-2-morpholino-2-oxoethyl)methanesulfonamide
  • N-(3,4-dimethylphenyl)-N-(2-keto-1-methyl-2-morpholino-ethyl)methanesulfonamide
  • N-(3,4-dimethylphenyl)-N-(1-morpholin-4-yl-1-oxo-propan-2-yl)methanesulfonamide
  • MLS000693256
  • N-(3,4-dimethylphenyl)-N-[1-methyl-2-(4-morpholinyl)-2-oxoethyl]methanesulfonamide (non-preferred name)
  • SMR000300400

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine proteinase, putative 0.0079 0.0691 0.1412
Onchocerca volvulus 0.0138 0.1396 1
Brugia malayi Cathepsin L-like precursor 0.0138 0.1396 0.1786
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0035 0.0175 0.1254
Trypanosoma cruzi cysteine proteinase, putative 0.0079 0.0691 0.1412
Schistosoma mansoni cathepsin B (C01 family) 0.0035 0.0175 0.0186
Onchocerca volvulus 0.0138 0.1396 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0274 0.302 0.3014
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0211 0.2263 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0035 0.0175 0.0062
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0035 0.0175 0.1254
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0064 0.0512 0.1972
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1396 0.9103
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0175 0.0223
Schistosoma mansoni jumonji domain containing protein 0.0232 0.2512 0.267
Plasmodium vivax vivapain-2 0.0138 0.1396 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0415 0.0531
Trypanosoma brucei cysteine peptidase C (CPC) 0.0148 0.1517 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0008 0.0011
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0035 0.0175 0.1254
Giardia lamblia Cathepsin B precursor 0.0035 0.0175 0.0004
Brugia malayi nuclear receptor NHR-88 0.0021 0.0008 0.0011
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0138 0.1396 1
Entamoeba histolytica cysteine proteinase 2 0.0079 0.0691 0.4772
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0148 0.1517 0.3268
Echinococcus granulosus cysteine protease 0.0079 0.0691 0.0726
Toxoplasma gondii cathepsin CPC1 0.0035 0.0175 0.0774
Schistosoma mansoni hypothetical protein 0.0038 0.0206 0.0219
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0512 0.3374
Schistosoma mansoni pyruvate kinase 0.0035 0.0175 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0177 0.0074
Giardia lamblia Cathepsin B precursor 0.0035 0.0175 0.0004
Giardia lamblia Cathepsin L precursor 0.0035 0.0175 0.0004
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0008 0.0009
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.1396 0.2996
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.0512 0.1011
Plasmodium falciparum serine repeat antigen 6 0.0035 0.0175 0.1254
Trypanosoma cruzi cysteine peptidase, putative 0.0043 0.0269 0.0464
Echinococcus granulosus muscleblind protein 0.0677 0.7814 0.8305
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0082 0.0257
Schistosoma mansoni lipoxygenase 0.0023 0.0029 0.0031
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.0512 0.3374
Schistosoma mansoni aldehyde dehydrogenase 0.0211 0.2263 0.2405
Leishmania major cathepsin L-like protease 0.0138 0.1396 0.6062
Entamoeba histolytica cysteine protease, putative 0.0079 0.0691 0.4772
Loa Loa (eye worm) hypothetical protein 0.04 0.4514 0.5777
Schistosoma mansoni cathepsin s 0.0043 0.0269 0.0286
Loa Loa (eye worm) hypothetical protein 0.0035 0.0175 0.0224
Echinococcus multilocularis cathepsin b 0.04 0.4514 0.451
Onchocerca volvulus 0.0138 0.1396 1
Entamoeba histolytica cysteine protease, putative 0.0079 0.0691 0.4772
Echinococcus granulosus geminin 0.0353 0.3956 0.42
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0175 0.0253
Echinococcus multilocularis cathepsin L 0.0079 0.0691 0.0683
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0008 0.0011
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0175 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0512 0.3374
Loa Loa (eye worm) fibroinase 0.0138 0.1396 0.1786
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0138 0.1396 0.1389
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.0175 0.0224
Onchocerca volvulus 0.0095 0.088 0.6284
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0082 0.009
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0029 0.002
Toxoplasma gondii aldehyde dehydrogenase 0.0211 0.2263 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0064 0.0512 0.0544
Giardia lamblia Cathepsin L precursor 0.0035 0.0175 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0276 0.1822
Giardia lamblia Cathepsin B precursor 0.0035 0.0175 0.0004
Toxoplasma gondii cathepsin B 0.0148 0.1517 0.6705
Entamoeba histolytica cysteine protease, putative 0.0079 0.0691 0.4772
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1396 0.9103
Brugia malayi Cathepsin L-like precursor 0.0043 0.0269 0.0344
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0276 0.1822
Schistosoma mansoni pyruvate kinase 0.0035 0.0175 0.0186
Brugia malayi cathepsin L-like cysteine proteinase 0.0035 0.0175 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0035 0.0175 0.0062
Plasmodium falciparum serine repeat antigen 2 0.0035 0.0175 0.1254
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0175 0.1251
Brugia malayi Doublecortin family protein 0.0023 0.0029 0.0037
Schistosoma mansoni hypothetical protein 0.009 0.0821 0.0873
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.04 0.4514 0.4799
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0038 0.0208 0.0921
Plasmodium vivax vivapain-2 0.0138 0.1396 1
Leishmania major cathepsin L-like protease 0.0138 0.1396 0.6062
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0063 0.0509 0.0541
Onchocerca volvulus 0.0138 0.1396 1
Giardia lamblia Cathepsin B precursor 0.0035 0.0175 0.0004
Entamoeba histolytica cysteine protease, putative 0.0079 0.0691 0.4772
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0035 0.0175 0.1254
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0008 0.0009
Leishmania major cathepsin L-like protease 0.0138 0.1396 0.6062
Brugia malayi Cathepsin L-like precursor 0.0138 0.1396 0.1786
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0062 0.0079
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.0691 0.4772
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0175 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0175 0.0223
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0175 0.0058
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0274 0.302 0.3204
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0008 0.0011
Schistosoma mansoni alkaline phosphatase 0.0173 0.1808 0.1922
Echinococcus multilocularis expressed protein 0.0036 0.0177 0.0168
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0415 0.0531
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0167 0.0737
Plasmodium vivax serine-repeat antigen (SERA) 0.0035 0.0175 0.1254
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0064 0.0512 0.0504
Brugia malayi jmjC domain containing protein 0.0038 0.0208 0.0267
Entamoeba histolytica cysteine proteinase, putative 0.0138 0.1396 1
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0175 0.1201
Echinococcus multilocularis muscleblind protein 0.0677 0.7814 0.7813
Schistosoma mansoni jumonji domain containing protein 0.0038 0.0208 0.0221
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0035 0.0175 0.0004
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0208 0.0267
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0035 0.0175 0.1254
Brugia malayi Cathepsin L-like precursor 0.0138 0.1396 0.1786
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0043 0.0269 0.0344
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0167 0.0887
Leishmania major DNA polymerase kappa, putative 0.0064 0.0512 0.2045
Giardia lamblia Cysteine protease 0.0035 0.0175 0.0004
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0035 0.0175 0.1254
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0082 0.009
Entamoeba histolytica cysteine protease, putative 0.0079 0.0691 0.4772
Brugia malayi steroid hormone receptor 0.0021 0.0008 0.0011
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0035 0.0175 0.0949
Entamoeba histolytica cysteine protease, putative 0.0079 0.0691 0.4772
Plasmodium falciparum serine repeat antigen 7 0.0035 0.0175 0.1254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1396 0.9103
Leishmania major pyruvate kinase 0.0035 0.0175 0.0512
Echinococcus granulosus cathepsin l cysteine peptidase 0.0138 0.1396 0.1476
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0175 0.1151
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0411 0.0428
Loa Loa (eye worm) hypothetical protein 0.0043 0.0269 0.0344
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0173 0.1808 0.1915
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1396 0.9103
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0062 0.0079
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0411 0.0525
Giardia lamblia Cathepsin L-like protease 0.0035 0.0175 0.0004
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0512 0.0655
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.0691 0.4772
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.0512 0.1972
Echinococcus granulosus cathepsin L cysteine protease 0.0079 0.0691 0.0726
Echinococcus multilocularis cysteine protease 0.0138 0.1396 0.1389
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0082 0.0257
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0211 0.2263 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0148 0.1517 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0011
Loa Loa (eye worm) ctsf protein 0.0138 0.1396 0.1786
Entamoeba histolytica cysteine protease, putative 0.0079 0.0691 0.4772
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0175 0.0062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0411 0.0402
Loa Loa (eye worm) MH2 domain-containing protein 0.026 0.2853 0.3651
Brugia malayi Papain family cysteine protease containing protein 0.0079 0.0691 0.0884
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0082 0.009
Trichomonas vaginalis DNA polymerase eta, putative 0.0064 0.0512 0.2556
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0138 0.1396 0.9103
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0512 0.1011
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0038 0.0208 0.0213
Schistosoma mansoni lipoxygenase 0.0065 0.0525 0.0559
Echinococcus multilocularis cathepsin L cysteine protease 0.0138 0.1396 0.1389
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.0509 0.2248
Plasmodium falciparum cysteine proteinase falcipain 3 0.0138 0.1396 1
Schistosoma mansoni loxhd1 0.0023 0.0029 0.0031
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0175 0.1197
Schistosoma mansoni rotamase 0.0036 0.0177 0.0188
Plasmodium falciparum cysteine proteinase falcipain 1 0.0079 0.0691 0.4948
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0029 0.0207
Giardia lamblia Cathepsin B precursor 0.0148 0.1517 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0035 0.0175 0.0004
Echinococcus granulosus lysine specific demethylase 5A 0.0143 0.146 0.1545
Entamoeba histolytica cysteine protease, putative 0.0035 0.0175 0.0949
Loa Loa (eye worm) hypothetical protein 0.0035 0.0175 0.0224
Entamoeba histolytica cysteine proteinase 1, putative 0.0079 0.0691 0.4772
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1396 0.9201
Mycobacterium ulcerans aldehyde dehydrogenase 0.0211 0.2263 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0079 0.0691 0.0734
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0175 0.0062
Brugia malayi PHD-finger family protein 0.0063 0.0509 0.0651
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0035 0.0175 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0175 0.0062
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0011
Echinococcus granulosus JmjC domain containing protein 4 0.0038 0.0208 0.0213
Entamoeba histolytica cysteine protease, putative 0.0035 0.0175 0.0949
Loa Loa (eye worm) hypothetical protein 0.0038 0.0208 0.0267
Schistosoma mansoni cathepsin F (C01 family) 0.0095 0.088 0.0936
Echinococcus multilocularis cathepsin L 0.0035 0.0175 0.0167
Entamoeba histolytica cysteine protease, putative 0.0035 0.0175 0.0949
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.1396 0.2996
Entamoeba histolytica cysteine protease, putative 0.0138 0.1396 1
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0175 0.1197
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0037
Echinococcus multilocularis PHD finger protein rhinoceros 0.0063 0.0509 0.0501
Echinococcus granulosus peregrin 0.0063 0.0509 0.0532
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.088 0.5284
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0175 0.1151
Plasmodium vivax serine-repeat antigen (SERA) 0.0035 0.0175 0.1254
Plasmodium vivax unspecified product 0.0035 0.0175 0.1254
Echinococcus multilocularis jumonji domain containing protein 0.0088 0.0805 0.0797
Toxoplasma gondii cathepsin CPL 0.0138 0.1396 0.617
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1396 0.9103
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0008 0.0009
Schistosoma mansoni coup transcription factor 0.0021 0.0008 0.0009
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0035 0.0175 0.0186
Brugia malayi Cathepsin L-like precursor 0.0138 0.1396 0.1786
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0082 0.009
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0082 0.009
Trypanosoma cruzi major cysteine proteinase, putative 0.0035 0.0175 0.0254
Giardia lamblia Cathepsin B precursor 0.0148 0.1517 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0035 0.0175 0.0186
Trypanosoma brucei unspecified product 0.0044 0.0276 0.1822
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0079 0.0691 0.1412
Echinococcus granulosus pyruvate kinase 0.0035 0.0175 0.0177
Plasmodium falciparum serine repeat antigen 9 0.0035 0.0175 0.1254
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1396 0.9201
Plasmodium vivax unspecified product 0.0079 0.0691 0.4948
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0008 0.0011
Schistosoma mansoni hypothetical protein 0.0078 0.0685 0.0729
Trypanosoma cruzi cruzipain precursor, putative 0.0138 0.1396 0.2996
Loa Loa (eye worm) hypothetical protein 0.0043 0.0269 0.0344
Loa Loa (eye worm) hypothetical protein 0.0056 0.0415 0.0531
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.0512 0.3374
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0035 0.0175 0.1254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0175 0.0062
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0035 0.0175 0.0186
Leishmania major cathepsin L-like protease 0.0138 0.1396 0.6062
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0008 0.0011
Schistosoma mansoni cathepsin F (C01 family) 0.0138 0.1396 0.1484
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0035 0.0175 0.0062
Echinococcus multilocularis alkaline phosphatase 0.0173 0.1808 0.1801
Echinococcus granulosus cathepsin b 0.04 0.4514 0.4794
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1396 0.9103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0691 0.4553
Loa Loa (eye worm) cysteine protease 0.0138 0.1396 0.1786
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0211 0.2263 0.2398
Schistosoma mansoni hypothetical protein 0.0063 0.0509 0.0541
Echinococcus granulosus pyruvate kinase 0.0035 0.0175 0.0177
Brugia malayi Muscleblind-like protein 0.0677 0.7814 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0035 0.0175 0.0224
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0175 0.0426
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1396 0.9103
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0175 0.0223
Echinococcus granulosus alkaline phosphatase 0.0173 0.1808 0.1915
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1396 0.9103
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0512 0.3374
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0095 0.088 0.1838
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0148 0.1517 0.1613
Echinococcus granulosus cathepsin L 0.0079 0.0691 0.0726
Entamoeba histolytica hypothetical protein 0.0035 0.0175 0.0949
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1396 0.9201
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0035 0.0175 0.0949
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1396 0.9103
Giardia lamblia Encystation-specific protease 0.0035 0.0175 0.0004
Echinococcus granulosus cathepsin b 0.04 0.4514 0.4794
Loa Loa (eye worm) jmjC domain-containing protein 0.0143 0.146 0.1869
Entamoeba histolytica cysteine proteinase, putative 0.0138 0.1396 1
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0175 0.0772
Plasmodium vivax vivapain-3 0.0079 0.0691 0.4948
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0411 0.0436
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0138 0.1396 0.1786
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1396 0.9103
Onchocerca volvulus Alhambra homolog 0.0063 0.0509 0.3605
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0029 0.0022
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0148 0.1517 0.6612
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0175 0.0058
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0082 0.009
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.04 0.4514 0.4799
Loa Loa (eye worm) hypothetical protein 0.0064 0.0512 0.0655
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0082 0.009
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0175 0.0223
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0065 0.0525 0.055
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0512 0.3374
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0008 0.0011
Schistosoma mansoni hypothetical protein 0.0353 0.3956 0.4205
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0035 0.0175 0.0186
Loa Loa (eye worm) cathepsin B 0.0148 0.1517 0.1941
Leishmania major cysteine peptidase A (CPA) 0.0138 0.1396 0.6062
Loa Loa (eye worm) hypothetical protein 0.0095 0.088 0.1126
Echinococcus granulosus cathepsin L 0.0035 0.0175 0.0177
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0082 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0008 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0691 0.4553
Schistosoma mansoni rab6-interacting 0.0023 0.0029 0.0031
Echinococcus granulosus RUN 0.0023 0.0029 0.0022
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0038 0.0208 0.0921
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1396 0.9103
Giardia lamblia Cathepsin B precursor 0.0148 0.1517 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0269 0.0344
Schistosoma mansoni hypothetical protein 0.0023 0.0029 0.0031
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0035 0.0175 0.0004
Brugia malayi fibroinase precursor 0.0035 0.0175 0.0224
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0167 0.0235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1396 0.9201
Schistosoma mansoni cathepsin F (C01 family) 0.0138 0.1396 0.1484
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0411 0.0525
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0691 0.1412
Brugia malayi cathepsin B-like cysteine proteinase 0.04 0.4514 0.5777
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0691 0.388
Plasmodium falciparum serine repeat antigen 3 0.0035 0.0175 0.1254
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0685 0.072
Brugia malayi Cathepsin L-like precursor 0.0138 0.1396 0.1786
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1396 0.9103
Loa Loa (eye worm) hypothetical protein 0.0028 0.0082 0.0105
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0029 0.0207
Entamoeba histolytica cysteine proteinase, putative 0.0095 0.088 0.6177
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0175 0.0062
Echinococcus multilocularis RUN 0.0023 0.0029 0.002
Echinococcus granulosus expressed protein 0.0036 0.0177 0.0179
Loa Loa (eye worm) hypothetical protein 0.0138 0.1396 0.1786
Plasmodium falciparum pyruvate kinase 0.0035 0.0175 0.1251
Giardia lamblia Cathepsin L precursor 0.0035 0.0175 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0035 0.0175 0.0062
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0411 0.0428
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0167 0.0235
Schistosoma mansoni phd/f-box containing protein 0.0038 0.0208 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0276 0.1822
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0008 0.0009
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0177 0.0226
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0008 0.0011
Plasmodium falciparum serine repeat antigen 8 0.0035 0.0175 0.1254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0175 0.0062
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0008 0.0011
Echinococcus multilocularis phd:f box containing protein 0.0038 0.0208 0.02
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0512 0.1011
Plasmodium vivax hypothetical protein, conserved 0.0063 0.0509 0.3643
Brugia malayi jmjC domain containing protein 0.0038 0.0208 0.0267
Schistosoma mansoni polycystin 1-related 0.0023 0.0029 0.0031
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0035 0.0175 0.1254
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0008 0.0011
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0038 0.0208 0.02
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0008 0.0011
Echinococcus granulosus dna polymerase eta 0.0064 0.0512 0.0536
Giardia lamblia Hypothetical protein 0.0035 0.0175 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0082 0.0105
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0065 0.0525 0.0517
Brugia malayi Cathepsin L-like precursor 0.0095 0.088 0.1126
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0062 0.0079
Echinococcus granulosus phd:f box containing protein 0.0038 0.0208 0.0213
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0008 0.0011
Trypanosoma brucei unspecified product 0.0044 0.0276 0.1822
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0082 0.0257
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.04 0.4514 0.4799
Onchocerca volvulus 0.0023 0.0029 0.0147
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0008 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1396 0.9103
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0011
Trypanosoma cruzi cysteine protease, putative 0.0079 0.0691 0.1412
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.0691 0.4772
Loa Loa (eye worm) hypothetical protein 0.0035 0.0175 0.0224
Schistosoma mansoni microtubule-associated protein tau 0.0811 0.9408 1
Plasmodium falciparum serine repeat antigen 4 0.0035 0.0175 0.1254
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1396 0.9103
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0173 0.1808 0.1915
Brugia malayi jmjC domain containing protein 0.0274 0.302 0.3865
Brugia malayi hypothetical protein 0.0023 0.0029 0.0037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0411 0.0436
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0035 0.0175 0.1254
Echinococcus granulosus cathepsin L cysteine proteinase 0.0138 0.1396 0.1476
Echinococcus granulosus jumonji domain containing 1A 0.0038 0.0208 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0008 0.0011
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0175 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0008 0.0011
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0685 0.0678
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.1396 0.2996
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0691 0.388
Echinococcus granulosus PHD finger protein rhinoceros 0.0063 0.0509 0.0532
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0028 0.0082 0.0105
Entamoeba histolytica cysteine protease, putative 0.0035 0.0175 0.0949
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1396 0.9201
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0458 0.0586
Schistosoma mansoni cathepsin C 0.0035 0.0175 0.0186
Brugia malayi cathepsin F-like cysteine proteinase 0.0035 0.0175 0.0224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0008 0.0011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0008 0.0009
Schistosoma mansoni phosphatidylserine receptor 0.0038 0.0208 0.0221
Loa Loa (eye worm) hypothetical protein 0.0095 0.088 0.1126
Echinococcus multilocularis lysine specific demethylase 6a 0.0038 0.0208 0.02
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0064 0.0512 0.0536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1396 0.9103
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0035 0.0175 0.0186
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0173 0.1808 0.1801
Onchocerca volvulus 0.0028 0.0082 0.0528
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0175 0.0062
Entamoeba histolytica cysteine protease, putative 0.0079 0.0691 0.4772
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0035 0.0175 0.0004
Leishmania major cathepsin L-like protease 0.0138 0.1396 0.6062
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0138 0.1396 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0175 0.0062
Schistosoma mansoni cathepsin S (C01 family) 0.0035 0.0175 0.0186
Plasmodium vivax unspecified product 0.0043 0.0269 0.1925
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1396 0.9103
Toxoplasma gondii preprocathepsin c precursor, putative 0.0035 0.0175 0.0774
Onchocerca volvulus 0.0138 0.1396 1
Entamoeba histolytica hypothetical protein 0.0078 0.0685 0.4733
Leishmania major cathepsin L-like protease 0.0138 0.1396 0.6062
Brugia malayi Cathepsin L-like cysteine proteinase 0.0095 0.088 0.1126
Trypanosoma cruzi cruzipain precursor, putative 0.0043 0.0269 0.0464
Loa Loa (eye worm) hypothetical protein 0.0127 0.126 0.1612
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0082 0.0105
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0167 0.1099
Loa Loa (eye worm) hypothetical protein 0.0035 0.0175 0.0224
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0035 0.0175 0.0186
Entamoeba histolytica cysteine protease, putative 0.0079 0.0691 0.4772
Mycobacterium ulcerans hypothetical protein 0.0028 0.0082 0.009
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0175 0.0512
Giardia lamblia DINP protein human, muc B family 0.0064 0.0512 0.2512
Entamoeba histolytica cysteine protease, putative 0.0079 0.0691 0.4772
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0035 0.0175 0.1254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1396 0.9103
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0082 0.0105
Brugia malayi cathepsin L precursor 0.0035 0.0175 0.0224
Plasmodium falciparum JmjC domain-containing protein, putative 0.0038 0.0208 0.1492
Brugia malayi Cytochrome P450 family protein 0.0026 0.0062 0.0079
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0008 0.0009
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0167 0.0476
Brugia malayi jmjC domain containing protein 0.0038 0.0208 0.0267
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0177 0.0226
Schistosoma mansoni rab6-interacting 0.0023 0.0029 0.0031
Schistosoma mansoni jumonji/arid domain-containing protein 0.0143 0.146 0.1552
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1396 0.9103
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.04 0.4514 1
Echinococcus multilocularis pyruvate kinase 0.0035 0.0175 0.0166
Onchocerca volvulus 0.0138 0.1396 1
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.0512 0.3374
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0512 0.3374
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0037
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0173 0.1808 0.1801
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1396 0.9201
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0043 0.0269 0.0344
Schistosoma mansoni hypothetical protein 0.0353 0.3956 0.4205
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0038 0.0208 0.0329
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.0691 0.4772
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0082 0.009
Plasmodium falciparum serine repeat antigen 5 0.0035 0.0175 0.1254
Brugia malayi jmjC domain containing protein 0.0038 0.0208 0.0267
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0008 0.0011
Leishmania major cathepsin L-like protease 0.0138 0.1396 0.6062
Trypanosoma cruzi major cysteine proteinase, putative 0.0035 0.0175 0.0254
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0208 0.0267
Plasmodium vivax JmjC domain containing protein 0.0038 0.0208 0.1492
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0029 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0011
Giardia lamblia Cathepsin L precursor 0.0035 0.0175 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0035 0.0175 0.0062
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0211 0.2263 1
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0175 0.0224
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0512 0.3374
Mycobacterium ulcerans DNA polymerase IV 0.0064 0.0512 0.2045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0411 0.0436
Echinococcus multilocularis pyruvate kinase 0.0035 0.0175 0.0166
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0079 0.0691 0.0734
Giardia lamblia Cysteine protease 0.0035 0.0175 0.0004
Trichomonas vaginalis rotamase, putative 0.0036 0.0177 0.0074
Echinococcus granulosus dna polymerase kappa 0.0064 0.0512 0.0536
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1396 0.9201
Onchocerca volvulus 0.0023 0.0029 0.0147
Leishmania major DNA polymerase eta, putative 0.0064 0.0512 0.2045
Chlamydia trachomatis pyruvate kinase 0.0035 0.0175 0.5
Giardia lamblia PHD finger protein 15 0.0063 0.0509 0.2488
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0173 0.1808 0.1801
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0512 0.3374
Giardia lamblia Cysteine protease 0.0035 0.0175 0.0004
Schistosoma mansoni jumonji/arid domain-containing protein 0.0143 0.146 0.1552
Brugia malayi Papain family cysteine protease containing protein 0.0138 0.1396 0.1786
Echinococcus granulosus intestinal type alkaline phosphatase 0.0173 0.1808 0.1915
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0011
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0138 0.1396 0.1786
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1396 0.9103
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0512 0.0655
Brugia malayi Papain family cysteine protease containing protein 0.0079 0.0691 0.0884
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0211 0.2263 0.2256
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0079 0.0691 0.0734
Echinococcus multilocularis pyruvate kinase 0.0028 0.0086 0.0077
Mycobacterium ulcerans DNA polymerase IV 0.0064 0.0512 0.2045
Echinococcus granulosus lysine specific demethylase 6a 0.0038 0.0208 0.0213
Brugia malayi Cytochrome P450 family protein 0.0026 0.0062 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0512 0.3374
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0206 0.0263
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0138 0.1396 0.9103
Giardia lamblia Cysteine protease 0.0035 0.0175 0.0004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0415 0.0531
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0035 0.0175 0.1254
Onchocerca volvulus Cathepsin F homolog 0.0138 0.1396 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0035 0.0175 0.0224
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0029 0.002
Giardia lamblia Hypothetical protein 0.0035 0.0175 0.0004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0211 0.2263 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.04 0.4514 0.4799
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0035 0.0175 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1396 0.9201
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0175 0.0253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0008 0.0011
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0064 0.0512 0.2556
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0175 0.0223
Entamoeba histolytica cysteine protease, putative 0.0079 0.0691 0.4772
Onchocerca volvulus 0.0035 0.0175 0.1201
Onchocerca volvulus 0.0138 0.1396 1
Onchocerca volvulus Cathepsin L homolog 0.0138 0.1396 1
Entamoeba histolytica hypothetical protein 0.0078 0.0685 0.4733
Entamoeba histolytica hypothetical protein 0.0078 0.0685 0.4733
Brugia malayi hypothetical protein 0.0023 0.0029 0.0037
Echinococcus multilocularis dna polymerase eta 0.0064 0.0512 0.0504
Brugia malayi Cathepsin L-like precursor 0.0138 0.1396 0.1786
Loa Loa (eye worm) jmjC domain-containing protein 0.0131 0.1313 0.168
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0038 0.0208 0.0329
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1396 0.9103
Echinococcus multilocularis dna polymerase kappa 0.0064 0.0512 0.0504
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0035 0.0175 0.0062
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0035 0.0175 0.1254
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0512 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1396 0.9103
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.006
Trypanosoma brucei unspecified product 0.0064 0.0512 0.3374
Plasmodium falciparum serine repeat antigen 1 0.0035 0.0175 0.1254
Brugia malayi cathepsin L-like precursor 0.0095 0.088 0.1126
Entamoeba histolytica cysteine protease, putative 0.0079 0.0691 0.4772
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0008 0.0009
Echinococcus granulosus microtubule associated protein 2 0.0811 0.9408 1
Giardia lamblia Cathepsin L precursor 0.0035 0.0175 0.0004
Loa Loa (eye worm) PHD-finger family protein 0.0063 0.0509 0.0651
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0008 0.0009
Echinococcus multilocularis microtubule associated protein 2 0.0811 0.9408 0.9407
Loa Loa (eye worm) hypothetical protein 0.0038 0.0206 0.0263
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0685 0.0729
Brugia malayi MH2 domain containing protein 0.026 0.2853 0.3651
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0035 0.0175 0.0186
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0038 0.0208 0.1373
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0008 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0175 0.0062
Onchocerca volvulus Cathepsin L homolog 0.0138 0.1396 1
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.1396 0.2996
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0029 0.0037
Echinococcus multilocularis cathepsin b 0.04 0.4514 0.451
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0512 0.3374
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1396 0.9201
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.0175 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.088 0.5284
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1396 0.9201
Plasmodium falciparum phd finger protein, putative 0.0063 0.0509 0.3643
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0175 0.0224
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.0509 0.2248
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0175 0.0062
Plasmodium vivax vivapain-1 0.0079 0.0691 0.4948
Loa Loa (eye worm) hypothetical protein 0.0035 0.0175 0.0224
Loa Loa (eye worm) hypothetical protein 0.0095 0.088 0.1126
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0064 0.0512 0.2045
Brugia malayi Cathepsin L-like precursor 0.0095 0.088 0.1126
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0082 0.009
Echinococcus multilocularis geminin 0.0353 0.3956 0.3951
Brugia malayi Bromodomain containing protein 0.0063 0.0509 0.0651
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0175 0.0062
Schistosoma mansoni aldehyde dehydrogenase 0.0211 0.2263 0.2405
Entamoeba histolytica cysteine protease, putative 0.0035 0.0175 0.0949
Schistosoma mansoni terminal deoxycytidyl transferase 0.0064 0.0512 0.0544
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0029 0.0022
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0512 0.1011
Leishmania major hypothetical protein, conserved 0.0038 0.0208 0.0665
Giardia lamblia Cathepsin L-like protease 0.0035 0.0175 0.0004
Giardia lamblia Cathepsin L precursor 0.0035 0.0175 0.0004
Echinococcus granulosus cathepsin l1 0.0138 0.1396 0.1476
Echinococcus multilocularis peregrin 0.0063 0.0509 0.0501
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.0512 0.3374
Leishmania major cathepsin L-like protease 0.0138 0.1396 0.6062
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0062 0.0408
Entamoeba histolytica cysteine protease, putative 0.0035 0.0175 0.0949
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0008 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0082 0.009
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0175 0.1197
Echinococcus multilocularis muscleblind protein 1 0.0677 0.7814 0.7813
Echinococcus multilocularis cysteine protease 0.0138 0.1396 0.1389
Brugia malayi ecdysteroid receptor 0.0021 0.0008 0.0011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0411 0.0402
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0208 0.0267
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0008 0.0009
Schistosoma mansoni protein phosphatase 2C 0.0038 0.0208 0.0221
Schistosoma mansoni DNA polymerase eta 0.0064 0.0512 0.0544
Entamoeba histolytica hypothetical protein 0.0078 0.0685 0.4733
Echinococcus granulosus jumonji domain containing protein 0.0088 0.0805 0.0847
Entamoeba histolytica cysteine protease, putative 0.0079 0.0691 0.4772
Loa Loa (eye worm) hypothetical protein 0.0038 0.0208 0.0267
Echinococcus granulosus cathepsin l1 0.0095 0.088 0.0928
Brugia malayi nuclear hormone receptor 0.0021 0.0008 0.0011
Echinococcus multilocularis JmjC domain containing protein 4 0.0038 0.0208 0.02
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1396 0.9201
Brugia malayi Cytochrome P450 family protein 0.0059 0.0458 0.0586
Toxoplasma gondii cathepsin CPC2 0.0035 0.0175 0.0774
Brugia malayi jmjC domain containing protein 0.0143 0.146 0.1869
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1396 0.9103
Echinococcus multilocularis cathepsin L cysteine protease 0.0138 0.1396 0.1389
Loa Loa (eye worm) hypothetical protein 0.0677 0.7814 1
Brugia malayi hypothetical protein 0.0078 0.0685 0.0877
Loa Loa (eye worm) transcription factor SMAD2 0.026 0.2853 0.3651
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1396 0.9103
Leishmania major pyruvate kinase 0.0035 0.0175 0.0512
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0047 0.006
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0008 0.0011
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0035 0.0175 0.0224
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0029 0.0022
Echinococcus multilocularis jumonji domain containing 1A 0.0038 0.0208 0.02
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0008 0.0011
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0038 0.0208 0.0221
Loa Loa (eye worm) hypothetical protein 0.0063 0.0509 0.0651
Loa Loa (eye worm) hypothetical protein 0.0677 0.7814 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0043 0.0269 0.0344
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0008 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0035 0.0175 0.0062
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0138 0.1396 0.1389
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0035 0.0175 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0512 0.3374
Brugia malayi cathepsin Z-like cysteine proteinase 0.0035 0.0175 0.0224
Entamoeba histolytica deoxycytidyl transferase, putative 0.0064 0.0512 0.3446
Echinococcus multilocularis lysine specific demethylase 5A 0.0143 0.146 0.1453
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0008 0.0011
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0035 0.0175 0.1254
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0064 0.0512 0.0655
Schistosoma mansoni alkaline phosphatase 0.0173 0.1808 0.1922
Loa Loa (eye worm) hypothetical protein 0.0035 0.0175 0.0224
Giardia lamblia Cathepsin B precursor 0.0035 0.0175 0.0004

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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