Detailed information for compound 1550332

Basic information

Technical information
  • TDR Targets ID: 1550332
  • Name: (4-methoxyphenyl)methyl N-[[(3aR,5aS,8R,9S,9a S,9bS)-8,9-dihydroxy-1,3-dioxo-2-[[(2S)-oxola n-2-yl]methyl]-4,5,5a,7,8,9,9a,9b-octahydro-3 aH-benzo[e]isoindol-6-ylidene]amino]carbamate
  • MW: 515.556 | Formula: C26H33N3O8
  • H donors: 3 H acceptors: 5 LogP: 0.28 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)COC(=O)N/N=C/1\C[C@@H](O)[C@H]([C@H]2[C@@H]1CC[C@@H]1[C@H]2C(=O)N(C1=O)C[C@@H]1CCCO1)O
  • InChi: 1S/C26H33N3O8/c1-35-15-6-4-14(5-7-15)13-37-26(34)28-27-19-11-20(30)23(31)21-17(19)8-9-18-22(21)25(33)29(24(18)32)12-16-3-2-10-36-16/h4-7,16-18,20-23,30-31H,2-3,8-13H2,1H3,(H,28,34)/b27-19+/t16-,17+,18+,20+,21-,22+,23+/m0/s1
  • InChiKey: FVIMMMWJEUMOOO-QTZIGNFFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4-methoxyphenyl)methyl N-[[(3aR,5aS,8R,9S,9aS,9bS)-8,9-dihydroxy-1,3-dioxo-2-[[(2S)-tetrahydrofuran-2-yl]methyl]-4,5,5a,7,8,9,9a,9b-octahydro-3aH-benzo[e]isoindol-6-ylidene]amino]carbamate
  • N-[[(3aR,5aS,8R,9S,9aS,9bS)-8,9-dihydroxy-1,3-dioxo-2-[[(2S)-2-tetrahydrofuranyl]methyl]-4,5,5a,7,8,9,9a,9b-octahydro-3aH-benzo[e]isoindol-6-ylidene]amino]carbamic acid (4-methoxyphenyl)methyl ester
  • N-[[(3aR,5aS,8R,9S,9aS,9bS)-8,9-dihydroxy-1,3-diketo-2-(tetrahydrofurfuryl)-4,5,5a,7,8,9,9a,9b-octahydro-3aH-benzo[e]isoindol-6-ylidene]amino]carbamic acid (4-methoxybenzyl) ester
  • CMLD2_000518
  • CMLDBU00002412

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0029 0.0106 0.0105
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0516 1
Schistosoma mansoni cpg binding protein 0.003 0.0111 0.0111
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0385 0.1707 0.1707
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0516 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0006 0.0085
Trichomonas vaginalis bromodomain-containing protein 3, brd3, putative 0.0006 0 0.0063
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0081 0.1483
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1148 0.5136 0.5136
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0006 0.0085
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis bromodomain containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0006 0 0.0063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.005 0.0944
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0248 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0081 0.0158
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0248 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.005 0.0097
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0029 0.0106 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0076 0.6553
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.005 0.0944
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0081 0.3115
Toxoplasma gondii exonuclease III APE 0.0023 0.0076 0.3062
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.3721 0.372
Echinococcus multilocularis ferritin 0.001 0.002 0.002
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0006 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0006 0.0085
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0029 0.0029
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0076 0.0076
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0516 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0048 0.0093
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0006 0 0.0063
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0076 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0081 0.0081
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0248 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0076 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0048 0.0093
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0081 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0081 0.0158
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0054 0.2
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0029 0.0106 0.2033
Plasmodium vivax SET domain containing protein 0.0006 0.0003 0.0151
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0004 0.0486
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0006 0 0.0063
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.3721 0.372
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0006 0.0006
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0385 0.1707 0.1707
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0006 0.0213
Schistosoma mansoni serine/threonine protein kinase 0.223 1 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0076 0.1459
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0006 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Loa Loa (eye worm) tyrosinase 1 0.0385 0.1707 0.1707
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0007 0.0008 0.0007
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0006 0.0085
Treponema pallidum methionine aminopeptidase (map) 0.0029 0.0106 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0048 0.3267
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0006 0.0085
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0029 0.0106 0.0105
Trichomonas vaginalis lymphoid specific helicase, putative 0.0006 0 0.0063
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0006 0 0.0063
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0076 0.2911
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0048 0.0093
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0006 0.0085
Echinococcus granulosus zinc finger protein 0.0007 0.0008 0.0007
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0048 0.0093
Schistosoma mansoni bromodomain containing protein 0.0007 0.0008 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0004 0.0486
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0004 0.0486
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0249 0.0249
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0054 0.1042
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0081 0.1483
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0248 0.4805
Brugia malayi TAZ zinc finger family protein 0.0332 0.1467 0.1467
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0081 0.1555
Onchocerca volvulus 0.0007 0.0006 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0048 0.1753
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0004 0.0486
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0004 0.0486
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Schistosoma mansoni ferritin 0.001 0.002 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.005 0.0944
Toxoplasma gondii hypothetical protein 0.0017 0.005 0.2013
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0054 0.1029
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0048 0.6321
Trichomonas vaginalis bromodomain containing protein, putative 0.0006 0 0.0063
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0076 0.0076
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Onchocerca volvulus 0.0385 0.1707 1
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0188 0.0188
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Plasmodium falciparum HP12 protein homolog, putative 0.0017 0.005 0.2664
Onchocerca volvulus 0.0024 0.0081 0.0474
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0029 0.0106 0.1964
Brugia malayi ShTK domain containing protein 0.0385 0.1707 0.1707
Loa Loa (eye worm) hypothetical protein 0.0587 0.2612 0.2612
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0081 0.3115
Brugia malayi Common central domain of tyrosinase family protein 0.0385 0.1707 0.1707
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Schistosoma mansoni apoferritin-2 0.001 0.002 0.002
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Schistosoma mansoni hypothetical protein 0.0451 0.2003 0.2003
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Echinococcus multilocularis expressed protein 0.001 0.002 0.002
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0006 0.001
Trypanosoma brucei methionine aminopeptidase, putative 0.0046 0.0182 0.0353
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0048 0.2553
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Plasmodium falciparum glutathione reductase 0.0047 0.0188 1
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0248 0.0248
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0006 0.0754
Loa Loa (eye worm) hypothetical protein 0.0024 0.0081 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0006 0.001
Schistosoma mansoni ferritin light chain 0.001 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0006 0.0006
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0029 0.0106 0.5629
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0076 0.0076
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0029 0.0106 0.4127
Echinococcus granulosus CREB binding protein 0.0205 0.0895 0.0895
Trichomonas vaginalis bromodomain containing protein, putative 0.0006 0 0.0063
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0461 0.8943
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Loa Loa (eye worm) hypothetical protein 0.0024 0.0081 0.0081
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0104 0.0104
Echinococcus granulosus calcium activated potassium channel 0.0009 0.0015 0.0014
Entamoeba histolytica ankyrin repeat protein, putative 0.0006 0 0.00000093048
Loa Loa (eye worm) methionine aminopeptidase type I 0.0046 0.0182 0.0182
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0188 0.0365
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0006 0.0282
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0046 0.0182 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0006 0.001
Loa Loa (eye worm) ShTK domain-containing protein 0.0385 0.1707 0.1707
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0385 0.1707 0.1707
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0006 0.0006
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0007 0.0008 0.0007
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0048 0.0093
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0188 0.3625
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0006 0.0754
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0048 0.0048
Trichomonas vaginalis bromodomain containing protein, putative 0.0006 0 0.0063
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0081 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0048 0.0093
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0081 0.0158
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0081 0.3115
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0081 0.3115
Echinococcus granulosus CREB binding protein 0.0332 0.1467 0.1467
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0248 0.0248
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0004 0.0486
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0054 0.2874
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0461 0.8943
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0048 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Echinococcus multilocularis cpg binding protein 0.003 0.0111 0.0111
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0181 0.018
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0014 0.0014
Mycobacterium ulcerans methionine aminopeptidase 0.0029 0.0106 0.4127
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0004 0.0486
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0181 0.018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0181 0.018
Brugia malayi Methionine aminopeptidase protein type I 0.0046 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.1148 0.5136 0.5136
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0046 0.0182 0.0353
Loa Loa (eye worm) hypothetical protein 0.0156 0.0675 0.0675
Schistosoma mansoni cpg binding protein 0.003 0.0111 0.0111
Echinococcus granulosus MAP kinase activated protein kinase 2 0.223 1 1
Echinococcus multilocularis CREB binding protein 0.0054 0.0219 0.0219
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Plasmodium vivax hypothetical protein, conserved 0.0017 0.005 0.2664
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0007 0.0006
Loa Loa (eye worm) oxidoreductase 0.0007 0.0006 0.0006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0029 0.0106 0.5629
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0048 0.0048
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Echinococcus granulosus expressed protein 0.001 0.002 0.002
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0014 0.0014
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0461 0.8943
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0188 0.0187
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Brugia malayi glutathione reductase 0.0047 0.0188 0.0188
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0004 0.0486
Brugia malayi Thioredoxin reductase 0.0047 0.0188 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.001 0.002 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Schistosoma mansoni tyrosinase precursor 0.0385 0.1707 0.1707
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Giardia lamblia Kinase, putative 0.0006 0 0.0063
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0006 0.0005
Mycobacterium ulcerans bacterioferritin BfrB 0.001 0.002 0.0601
Onchocerca volvulus 0.0007 0.0006 0.0031
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Schistosoma mansoni bromodomain containing protein 0.0007 0.0008 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Echinococcus granulosus ferritin 0.001 0.002 0.002
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Plasmodium falciparum thioredoxin reductase 0.0047 0.0188 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0029 0.0106 0.1964
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0046 0.0182 0.9689
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0048 0.1929
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0054 0.2874
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0006 0.0213
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0046 0.0182 0.0353
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0181 0.018
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0006 0.0085
Plasmodium vivax glutathione reductase, putative 0.0047 0.0188 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0248 0.0248
Chlamydia trachomatis methionine aminopeptidase 0.0029 0.0106 1
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0006 0.0006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0006 0.001
Leishmania major C-8 sterol isomerase-like protein 0.1148 0.5136 1
Mycobacterium tuberculosis Bacterioferritin BfrB 0.001 0.002 0.0369
Loa Loa (eye worm) hypothetical protein 0.0024 0.0081 0.0081
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0006 0.001
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0048 0.0093
Echinococcus multilocularis CREB binding protein 0.0054 0.0219 0.0219
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.0006 0.0653
Trypanosoma brucei C-8 sterol isomerase, putative 0.1148 0.5136 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0076 0.0148
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0248 0.0483
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0046 0.0182 0.0353
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0181 0.018
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0461 0.8943
Trypanosoma brucei RNA helicase, putative 0.0451 0.2003 0.39
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0048 0.0093
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0048 0.0093
Schistosoma mansoni ferritin 0.001 0.002 0.002
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.223 1 1
Schistosoma mansoni tyrosinase precursor 0.0385 0.1707 0.1707
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0004 0.0486
Onchocerca volvulus 0.0007 0.0006 0.0031
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0248 0.0248
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0046 0.0182 0.9689
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0048 0.0093
Trichomonas vaginalis helicase, putative 0.0007 0.0004 0.0486
Onchocerca volvulus 0.0029 0.0104 0.0607
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0006 0.0085
Schistosoma mansoni cpg binding protein 0.0029 0.0104 0.0104
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0029 0.0029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.005 0.0944
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0081 0.1555
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0048 0.0093
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0006 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.005 0.0097
Echinococcus granulosus CREB binding protein 0.0054 0.0219 0.0219
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0006 0.001
Schistosoma mansoni ferritin 0.001 0.002 0.002
Echinococcus multilocularis CREB binding protein 0.0228 0.0998 0.0998
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0076 0.9389
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0014 0.0014
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0007 0.0006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0076 0.0148
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0006 0.0085
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0004 0.0486
Mycobacterium ulcerans hypothetical protein 0.0024 0.0081 0.3115
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0188 0.0187
Echinococcus granulosus cpg binding protein 0.003 0.0111 0.0111
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0048 0.3267
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Onchocerca volvulus 0.0385 0.1707 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0181 0.018
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0048 0.6321
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0076 0.6553
Schistosoma mansoni apoferritin-2 0.001 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0004 0.0486
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0181 0.018
Giardia lamblia Hypothetical protein 0.0006 0 0.0063
Loa Loa (eye worm) hypothetical protein 0.0385 0.1707 0.1707
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0008
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Giardia lamblia Hypothetical protein 0.0006 0 0.0063
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0076 0.0148
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0188 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0006
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1148 0.5136 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Schistosoma mansoni ap endonuclease 0.0023 0.0076 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Leishmania major hypothetical protein, conserved 0.0017 0.005 0.0097
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0006 0 0.0063
Plasmodium falciparum thioredoxin reductase 0.0016 0.0048 0.2553
Trichomonas vaginalis bromodomain containing protein, putative 0.0006 0 0.0063
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0181 0.0181
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0048 0.2553
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0046 0.0182 0.0353
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0516 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0006 0.001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Giardia lamblia Transcription regulatory protein SNF2 0.0006 0 0.0063
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.001 0.002 0.0369
Trichomonas vaginalis bromodomain containing protein, putative 0.0006 0 0.0063
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0048 0.0048
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0048 0.0912
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trypanosoma brucei trypanothione reductase 0.0047 0.0188 0.0365
Leishmania major trypanothione reductase 0.0047 0.0188 0.0365
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0029 0.0106 0.4252
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.223 1 1
Schistosoma mansoni zinc finger protein 0.0007 0.0008 0.0007
Onchocerca volvulus 0.0385 0.1707 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0048 0.0093
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.005 0.0097
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0006 0.0006
Echinococcus multilocularis zinc finger protein 0.0007 0.0008 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0007 0.0006
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0076 0.4054
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0048 0.2553
Onchocerca volvulus 0.0007 0.0006 0.0031
Loa Loa (eye worm) ShTK domain-containing protein 0.0385 0.1707 0.1707
Plasmodium falciparum glutathione reductase 0.0016 0.0048 0.2553
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein 4, brd4, putative 0.0006 0 0.0063
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0007 0.0006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0004 0.0486
Trichomonas vaginalis hypothetical protein 0.0006 0 0.0063
Mycobacterium tuberculosis Probable reductase 0.0108 0.0461 0.8943
Treponema pallidum NADH oxidase 0.0016 0.0048 0.3267
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0048 0.0093
Loa Loa (eye worm) hypothetical protein 0.0385 0.1707 0.1707
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0029 0.0106 0.2033
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0006 0.001
Brugia malayi PHD-finger family protein 0.0007 0.0008 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0081 0.0081
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0006 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis bromodomain and PHD finger-containing protein, putative 0.0006 0 0.0063
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0081 0.3115
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0461 0.8934
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0048 0.1929
Trichomonas vaginalis ferritin, putative 0.001 0.002 0.2664
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0004 0.0486
Echinococcus granulosus CREB binding protein 0.0054 0.0219 0.0219
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0048 0.2553
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0461 0.8943
Loa Loa (eye worm) hypothetical protein 0.0029 0.0103 0.0103
Toxoplasma gondii thioredoxin reductase 0.0047 0.0188 0.7554
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0081 0.0081
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0076 0.4054
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0332 0.1467 0.1467
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0006 0.0282
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0248 1
Toxoplasma gondii methionine aminopeptidase 0.0046 0.0182 0.7319
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Schistosoma mansoni ferritin 0.001 0.002 0.002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0076 1
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0046 0.0182 0.0182
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0048 0.6321
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Loa Loa (eye worm) CBP-B 0.0231 0.1011 0.1011
Toxoplasma gondii methionine aminopeptidase 0.0029 0.0106 0.4252
Brugia malayi Bromodomain containing protein 0.0007 0.0008 0.0008
Schistosoma mansoni ap endonuclease 0.0023 0.0076 0.0076
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0006 0.0006
Trichomonas vaginalis hypothetical protein 0.0006 0 0.0063
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0076 0.0148
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0048 0.0048
Plasmodium falciparum bromodomain protein 1 0.0006 0 0.00000040179
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0006 0 0.0063
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0048 0.1753
Brugia malayi CXXC zinc finger family protein 0.0029 0.0104 0.0104
Mycobacterium ulcerans bacterioferritin BfrA 0.001 0.002 0.0601
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0081 0.3115
Schistosoma mansoni ferritin light chain 0.001 0.002 0.002
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0385 0.1707 0.1707
Loa Loa (eye worm) glutathione reductase 0.0047 0.0188 0.0188
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0006 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0004 0.0486
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0081 0.3115
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0048 0.0093
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0004 0.0486
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0246 0.9905
Toxoplasma gondii bromodomain-containing protein 0.0006 0 0.00000030351
Trichomonas vaginalis conserved hypothetical protein 0.0006 0 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0004 0.0486
Echinococcus multilocularis calcium activated potassium channel 0.0009 0.0015 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0004 0.0486
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Echinococcus granulosus microtubule associated protein 2 0.0833 0.3721 0.372
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0081 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0048 0.1753
Schistosoma mansoni CREB-binding protein 2 0.0332 0.1467 0.1467
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0076 0.0076
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.0006 0.001
Onchocerca volvulus 0.0385 0.1707 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0007 0.0006
Echinococcus multilocularis CREB binding protein 0.0054 0.0219 0.0219
Plasmodium vivax hypothetical protein, conserved 0.0006 0 0.00000040179
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0048 0.0093
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0029 0.0106 0.0105
Trichomonas vaginalis bromodomain-containing protein, putative 0.0006 0 0.0063
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0048 0.0093
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0046 0.0182 0.0182

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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