Detailed information for compound 1558198

Basic information

Technical information
  • TDR Targets ID: 1558198
  • Name: N-butyl-4-chloro-N-(8-methyl-8-azabicyclo[3.2 .1]octan-3-yl)benzamide hydrochloride
  • MW: 371.344 | Formula: C19H28Cl2N2O
  • H donors: 0 H acceptors: 1 LogP: 5.27 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(C(=O)c1ccc(cc1)Cl)C1CC2CCC(C1)N2C.Cl
  • InChi: 1S/C19H27ClN2O.ClH/c1-3-4-11-22(19(23)14-5-7-15(20)8-6-14)18-12-16-9-10-17(13-18)21(16)2;/h5-8,16-18H,3-4,9-13H2,1-2H3;1H
  • InChiKey: UQXPJXNKZRBETP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 171261-28-2
  • Benzamide, N-butyl-4-chloro-N-(8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-, monohydrochloride, endo-
  • MLS000120337
  • N-butyl-4-chloro-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)benzamide
  • SMR000101962

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni notch 0.0107 0.204 0.2036
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Echinococcus multilocularis fat cadherin tumor suppressor 0.0107 0.204 0.2036
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Schistosoma mansoni amine GPCR 0.0016 0.0161 0.0156
Onchocerca volvulus 0.0015 0.0148 0.0215
Trichomonas vaginalis esterase, putative 0.0043 0.0733 1
Schistosoma mansoni histamine h1 receptor 0.0016 0.0161 0.0156
Echinococcus multilocularis nAChR subunit 0.0015 0.0148 0.0143
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0733 1
Schistosoma mansoni cytochrome P450 0.0012 0.0079 0.0074
Brugia malayi follicle stimulating hormone receptor 0.0016 0.0161 0.0234
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0101 0.1906 0.1902
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0733 0.0728
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.119 0.5664
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0161 0.0156
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0015 0.0148 0.0215
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0161 0.0156
Echinococcus granulosus G protein coupled receptor 139 0.0016 0.0161 0.0156
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0148 0.0215
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Schistosoma mansoni hypothetical protein 0.0107 0.204 0.2036
Onchocerca volvulus 0.0107 0.204 0.3061
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0215
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.5553 1
Echinococcus granulosus cytochrome P450 2K1 0.0012 0.0079 0.0074
Schistosoma mansoni adenoreceptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0331 0.6654 1
Brugia malayi Animal haem peroxidase family protein 0.0331 0.6654 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0733 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Brugia malayi Serotonin receptor 0.0016 0.0161 0.0234
Echinococcus multilocularis notch 0.0107 0.204 0.2036
Onchocerca volvulus 0.0101 0.1906 0.286
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Echinococcus granulosus protein jagged 1 0.0107 0.204 0.2036
Echinococcus granulosus notch 0.0107 0.204 0.2036
Echinococcus multilocularis neuropeptide FF receptor 2 0.0016 0.0161 0.0156
Schistosoma mansoni hypothetical protein 0.0107 0.204 0.2036
Brugia malayi hypothetical protein 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0331 0.6654 1
Brugia malayi hypothetical protein 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0016 0.0161 0.0234
Brugia malayi RE15519p 0.0016 0.0161 0.0234
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0015 0.0148 0.0143
Echinococcus granulosus g protein coupled receptor 0.0016 0.0161 0.0156
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0015 0.0148 0.0143
Echinococcus granulosus sex peptide receptor 0.0016 0.0161 0.0156
Echinococcus granulosus delta-like protein 1 0.0107 0.204 0.2036
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0161 0.0156
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0733 1
Onchocerca volvulus Slit protein homolog 0.0107 0.204 0.3061
Echinococcus multilocularis neurogenic locus notch protein 4 0.0107 0.204 0.2036
Onchocerca volvulus 0.0043 0.0733 0.1094
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0015 0.0148 0.0215
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0733 0.1194
Brugia malayi Animal haem peroxidase family protein 0.0331 0.6654 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Brugia malayi G protein-coupled receptor F59B2.13 0.0016 0.0161 0.0234
Brugia malayi hypothetical protein 0.0016 0.0161 0.0234
Echinococcus granulosus 7tm_1 domain containing protein 0.0016 0.0161 0.0156
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0016 0.0161 0.0156
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0733 0.1194
Mycobacterium tuberculosis Conserved protein 0.0043 0.0733 0.1194
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0148 0.0215
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0015 0.0148 0.0215
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0161 0.0156
Onchocerca volvulus 0.0331 0.6654 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0161 0.0156
Brugia malayi EGF-like domain containing protein 0.0107 0.204 0.3061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0161 0.0156
Schistosoma mansoni amine GPCR 0.0016 0.0161 0.0156
Onchocerca volvulus Putative cubilin 0.0107 0.204 0.3061
Loa Loa (eye worm) hypothetical protein 0.0043 0.0733 0.1094
Echinococcus granulosus neuropeptide receptor 0.0016 0.0161 0.0156
Schistosoma mansoni hypothetical protein 0.0107 0.204 0.2036
Brugia malayi Animal haem peroxidase family protein 0.0331 0.6654 1
Brugia malayi excitatory GABA receptor EXP-1A 0.0015 0.0148 0.0215
Echinococcus granulosus 7TM GPCR rhodopsin 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Brugia malayi AKH receptor 0.0016 0.0161 0.0234
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0161 0.0156
Echinococcus granulosus g protein coupled receptor 0.0016 0.0161 0.0156
Echinococcus granulosus glycine receptor subunit alpha 1 0.0015 0.0148 0.0143
Echinococcus granulosus glycine receptor subunit alpha 1 0.0015 0.0148 0.0143
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0015 0.0148 0.0215
Echinococcus granulosus glycine receptor subunit alpha 1 0.0015 0.0148 0.0143
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0015 0.0148 0.0143
Echinococcus multilocularis protein jagged 1 0.0107 0.204 0.2036
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0161 0.0156
Schistosoma mansoni biogenic amine receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Schistosoma mansoni nAChR subunit 0.0015 0.0148 0.0143
Brugia malayi Melatonin receptor type 1A 0.0016 0.0161 0.0234
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0148 0.0215
Echinococcus granulosus neuropeptide s receptor 0.0016 0.0161 0.0156
Schistosoma mansoni hypothetical protein 0.0016 0.0161 0.0156
Loa Loa (eye worm) TYRA-2 protein 0.0016 0.0161 0.0234
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0015 0.0148 0.0143
Schistosoma mansoni nAChR subunit 0.0015 0.0148 0.0143
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0016 0.0161 0.0234
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0016 0.001
Schistosoma mansoni hypothetical protein 0.0107 0.204 0.2036
Schistosoma mansoni hypothetical protein 0.0107 0.204 0.2036
Schistosoma mansoni opsin-like receptor 0.0016 0.0161 0.0156
Brugia malayi Calcium binding EGF domain containing protein 0.0107 0.204 0.3061
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Brugia malayi Cytochrome P450 family protein 0.0012 0.0079 0.0111
Schistosoma mansoni notch 0.0107 0.204 0.2036
Mycobacterium leprae Probable lipase LipE 0.0043 0.0733 1
Brugia malayi Cytochrome P450 family protein 0.0041 0.0676 0.1008
Schistosoma mansoni nAChR subunit 0.0015 0.0148 0.0143
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0016 0.0161 0.0156
Brugia malayi putative neuropeptide receptor 0.0016 0.0161 0.0234
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0161 0.0156
Onchocerca volvulus 0.0016 0.0161 0.0234
Echinococcus multilocularis allatostatin A receptor 0.0016 0.0161 0.0156
Schistosoma mansoni slit 0.0107 0.204 0.2036
Schistosoma mansoni hypothetical protein 0.0016 0.0161 0.0156
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0107 0.204 0.3061
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Onchocerca volvulus 0.0101 0.1906 0.286
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0161 0.0156
Onchocerca volvulus 0.0016 0.0161 0.0234
Brugia malayi neuropeptide F receptor 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Brugia malayi GCC2 and GCC3 family protein 0.0107 0.204 0.3061
Echinococcus granulosus g protein coupled receptor 0.0016 0.0161 0.0156
Brugia malayi cytochrome P450 0.0012 0.0079 0.0111
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0161 0.0156
Onchocerca volvulus 0.0016 0.0161 0.0234
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0161 0.0156
Brugia malayi hypothetical protein 0.0016 0.0161 0.0234
Echinococcus granulosus fmrfamide receptor 0.0016 0.0161 0.0156
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0215
Schistosoma mansoni nAChR subunit 0.0015 0.0148 0.0143
Brugia malayi Dopamine receptor protein 2 0.0016 0.0161 0.0234
Echinococcus granulosus orexin receptor type 2 0.0016 0.0161 0.0156
Leishmania major hypothetical protein, conserved 0.0043 0.0733 1
Onchocerca volvulus 0.0016 0.0161 0.0234
Onchocerca volvulus Peroxidasin homolog 0.0331 0.6654 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Schistosoma mansoni hypothetical protein 0.0107 0.204 0.2036
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Onchocerca volvulus 0.0035 0.0552 0.0822
Brugia malayi G protein-coupled receptor 0.0016 0.0161 0.0234
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0016 0.0161 0.0156
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0015 0.0148 0.0143
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0676 0.9125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Echinococcus multilocularis protein jagged 2 0.0107 0.204 0.2036
Loa Loa (eye worm) hypothetical protein 0.0094 0.1764 0.2645
Schistosoma mansoni hypothetical protein 0.0494 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0161 0.0156
Schistosoma mansoni notch 0.0107 0.204 0.2036
Schistosoma mansoni cell polarity protein 0.0107 0.204 0.2036
Echinococcus granulosus protein jagged 1 0.0107 0.204 0.2036
Loa Loa (eye worm) Notch2 0.0107 0.204 0.3061
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0161 0.0156
Schistosoma mansoni nAChR subunit 0.0015 0.0148 0.0143
Echinococcus granulosus fibropellin Ia 0.0107 0.204 0.2036
Echinococcus multilocularis neurogenic locus notch protein 0.0107 0.204 0.2036
Brugia malayi G-protein coupled receptor 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0215
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0161 0.0156
Brugia malayi Serotonin receptor 0.0016 0.0161 0.0234
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0015 0.0148 0.0143
Brugia malayi EGF-like domain containing protein 0.0107 0.204 0.3061
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Echinococcus granulosus neural cadherin 0.0107 0.204 0.2036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0161 0.0156
Schistosoma mansoni septate junction protein 0.0107 0.204 0.2036
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0016 0.0161 0.0234
Schistosoma mansoni notch 0.0107 0.204 0.2036
Echinococcus multilocularis G protein coupled receptor 139 0.0016 0.0161 0.0156
Schistosoma mansoni myosin xvIII 0.0016 0.0161 0.0156
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0016 0.0161 0.0156
Schistosoma mansoni neuropeptide receptor 0.0016 0.0161 0.0156
Brugia malayi Animal haem peroxidase family protein 0.0331 0.6654 1
Echinococcus granulosus somatostatin receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Brugia malayi EGF-like domain containing protein 0.0107 0.204 0.3061
Onchocerca volvulus 0.0043 0.0733 0.1094
Loa Loa (eye worm) ACC-1 protein 0.0015 0.0148 0.0215
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Onchocerca volvulus Putative nachr subunit 0.0015 0.0148 0.0215
Brugia malayi beta-lactamase family protein 0.0043 0.0733 0.1094
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0215
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0015 0.0148 0.0143
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0015 0.0148 0.0143
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0215
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0676 0.1008
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0161 0.0156
Brugia malayi putative neuropeptide receptor NPR1 0.0016 0.0161 0.0234
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0331 0.6654 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0161 0.0156
Echinococcus multilocularis neurogenic locus notch protein 0.0107 0.204 0.2036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0161 0.0156
Echinococcus multilocularis fibropellin Ia 0.0107 0.204 0.2036
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Loa Loa (eye worm) ACC-1 protein 0.0015 0.0148 0.0215
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Brugia malayi EGF-like domain containing protein 0.0107 0.204 0.3061
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0015 0.0148 0.0143
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0029 0.0435 0.0646
Loa Loa (eye worm) hypothetical protein 0.0331 0.6654 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0161 0.0156
Schistosoma mansoni opsin-like receptor 0.0016 0.0161 0.0156
Onchocerca volvulus Dual oxidase homolog 0.0331 0.6654 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0015 0.0148 0.0143
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0015 0.0148 0.0215
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0733 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0733 0.0728
Loa Loa (eye worm) hypothetical protein 0.0331 0.6654 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0161 0.0156
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0733 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0733 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0215
Brugia malayi Peroxidasin 0.0331 0.6654 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0161 0.0156
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0161 0.0234
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0161 0.0156
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0161 0.0156
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0161 0.0156
Echinococcus multilocularis somatostatin receptor 0.0016 0.0161 0.0156
Echinococcus granulosus dro:myosuppressin receptor 0.0016 0.0161 0.0156
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0161 0.0156
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0015 0.0148 0.0143
Echinococcus multilocularis cpg binding protein 0.0037 0.0593 0.0588
Loa Loa (eye worm) animal heme peroxidase 0.0331 0.6654 1
Brugia malayi G-protein coupled receptor 0.0016 0.0161 0.0234
Onchocerca volvulus 0.0107 0.204 0.3061
Echinococcus multilocularis glycine receptor subunit beta 0.0015 0.0148 0.0143
Onchocerca volvulus 0.0016 0.0161 0.0234
Schistosoma mansoni notch 0.0107 0.204 0.2036
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0016 0.0161 0.0234
Echinococcus granulosus neuropeptide receptor 0.0016 0.0161 0.0156
Brugia malayi notch-like transmembrane receptor 0.0107 0.204 0.3061
Onchocerca volvulus 0.0016 0.0161 0.0234
Brugia malayi Cadherin domain containing protein 0.0107 0.204 0.3061
Brugia malayi Cation transporter family protein 0.0101 0.1906 0.286
Echinococcus granulosus tachykinin peptides receptor 99D 0.0016 0.0161 0.0156
Echinococcus multilocularis neurogenic locus protein delta 0.0107 0.204 0.2036
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Onchocerca volvulus 0.0107 0.204 0.3061
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0215
Onchocerca volvulus 0.0107 0.204 0.3061
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0733 0.1194
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0733 0.1094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0161 0.0156
Echinococcus granulosus cpg binding protein 0.0037 0.0593 0.0588
Loa Loa (eye worm) hypothetical protein 0.0043 0.0733 0.1094
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0016 0.0161 0.0234
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0148 0.0215
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0015 0.0148 0.0143
Loa Loa (eye worm) hypothetical protein 0.0331 0.6654 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0016 0.0161 0.0156
Brugia malayi CXXC zinc finger family protein 0.0035 0.0552 0.0822
Mycobacterium ulcerans hypothetical protein 0.0043 0.0733 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0016 0.0161 0.0156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Brugia malayi larval opioid receptor 0.0016 0.0161 0.0234
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0015 0.0148 0.0143
Onchocerca volvulus 0.0016 0.0161 0.0234
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0733 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0733 0.1094
Brugia malayi Cation transporter family protein 0.0015 0.0148 0.0215
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0733 0.5
Brugia malayi Delta serrate ligand family protein 0.0107 0.204 0.3061
Brugia malayi hypothetical protein 0.0016 0.0161 0.0234
Toxoplasma gondii ABC1 family protein 0.0043 0.0733 0.3333
Loa Loa (eye worm) hypothetical protein 0.0331 0.6654 1
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0161 0.0156
Echinococcus multilocularis dro:myosuppressin receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0016 0.0161 0.0156
Onchocerca volvulus Neuropeptide F receptor homolog 0.0016 0.0161 0.0234
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0215
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0215
Echinococcus granulosus g-protein coupled receptor 0.0016 0.0161 0.0156
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0016 0.0161 0.0156
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0059 0.0054
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0161 0.0156
Schistosoma mansoni opsin-like receptor 0.0016 0.0161 0.0156
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0107 0.204 0.3061
Schistosoma mansoni cpg binding protein 0.0035 0.0552 0.0547
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0015 0.0148 0.0143
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0161 0.0156
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0733 0.1194
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0016 0.0161 0.0234
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0161 0.0156
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0161 0.0234
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0161 0.0156
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0016 0.001
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0733 1
Schistosoma mansoni amine GPCR 0.0016 0.0161 0.0156
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0016 0.0161 0.0156
Schistosoma mansoni alpha-1 adrenergic receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0215
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0015 0.0148 0.0143
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0016 0.0161 0.0156
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0161 0.0156
Echinococcus multilocularis neuropeptide receptor A26 0.0016 0.0161 0.0156
Brugia malayi hypothetical protein 0.0016 0.0161 0.0234
Schistosoma mansoni nAChR subunit 0.0015 0.0148 0.0143
Brugia malayi EGF-like domain containing protein 0.0107 0.204 0.3061
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0015 0.0148 0.0143
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0016 0.001
Echinococcus multilocularis neurogenic locus protein delta 0.0107 0.204 0.2036
Entamoeba histolytica hypothetical protein 0.0008 0.0005 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Onchocerca volvulus 0.0016 0.0161 0.0234
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0161 0.0156
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0148 0.0215
Echinococcus granulosus nAChR subunit 0.0015 0.0148 0.0143
Schistosoma mansoni amine GPCR 0.0016 0.0161 0.0156
Mycobacterium ulcerans beta-lactamase 0.0043 0.0733 1
Echinococcus multilocularis serotonin receptor 0.0016 0.0161 0.0156
Mycobacterium tuberculosis Conserved protein 0.0043 0.0733 0.1194
Brugia malayi Cytochrome P450 family protein 0.0012 0.0079 0.0111
Schistosoma mansoni hypothetical protein 0.0107 0.204 0.2036
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0552 0.0822
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0733 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0015 0.0148 0.0215
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0733 0.0728
Echinococcus granulosus hypothetical protein 0.0016 0.0161 0.0156
Brugia malayi ORL1-like opioid receptor 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0101 0.1906 0.286
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0331 0.6654 1
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0056 0.0077
Echinococcus multilocularis orexin receptor type 2 0.0016 0.0161 0.0156
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0016 0.0161 0.0156
Brugia malayi Calcium binding EGF domain containing protein 0.0107 0.204 0.3061
Brugia malayi EGF-like domain containing protein 0.0107 0.204 0.3061
Onchocerca volvulus 0.0107 0.204 0.3061
Echinococcus granulosus alpha 1A adrenergic receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0016 0.0161 0.0156
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0733 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Brugia malayi Dopamine receptor 0.0016 0.0161 0.0234
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0041 0.0676 0.9125
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0215
Echinococcus multilocularis serotonin receptor 0.0016 0.0161 0.0156
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0016 0.0161 0.0234
Brugia malayi EGF-like domain containing protein 0.0107 0.204 0.3061
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0733 0.1194
Loa Loa (eye worm) hypothetical protein 0.0043 0.0733 0.1094
Brugia malayi hypothetical protein 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0148 0.0215
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0161 0.0156
Echinococcus granulosus neurogenic locus protein delta 0.0107 0.204 0.2036
Echinococcus granulosus peroxidasin 0.0331 0.6654 0.6652
Brugia malayi Blistered cuticle protein 3 0.0331 0.6654 1
Onchocerca volvulus 0.0016 0.0161 0.0234
Onchocerca volvulus 0.0331 0.6654 1
Brugia malayi Dopamine receptor protein 1 0.0016 0.0161 0.0234
Brugia malayi hypothetical protein 0.0016 0.0161 0.0234
Brugia malayi Cadherin domain containing protein 0.0107 0.204 0.3061
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0215
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Onchocerca volvulus 0.0015 0.0148 0.0215
Brugia malayi neuropeptide F receptor 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Onchocerca volvulus 0.0016 0.0161 0.0234
Schistosoma mansoni neuropeptide receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Loa Loa (eye worm) hypothetical protein 0.0101 0.1906 0.286
Onchocerca volvulus 0.0016 0.0161 0.0234
Echinococcus granulosus allatostatin A receptor 0.0016 0.0161 0.0156
Onchocerca volvulus 0.0016 0.0161 0.0234
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0148 0.0215
Echinococcus granulosus peptide allatostatin:somatostatin 0.0016 0.0161 0.0156
Brugia malayi GnHR receptor homolog 0.0016 0.0161 0.0234
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0161 0.0156
Onchocerca volvulus Peroxidase homolog 0.0331 0.6654 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0015 0.0148 0.0143
Echinococcus granulosus slit 2 protein 0.0107 0.204 0.2036
Onchocerca volvulus 0.0043 0.0733 0.1094
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Brugia malayi beta-lactamase family protein 0.0043 0.0733 0.1094
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0733 0.1194
Onchocerca volvulus Neurogenic locus notch homolog 0.0107 0.204 0.3061
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0015 0.0148 0.0215
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Echinococcus multilocularis glycine receptor subunit beta 0.0015 0.0148 0.0143
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0215
Brugia malayi sulfakinin receptor protein 0.0016 0.0161 0.0234
Schistosoma mansoni peroxidasin 0.0331 0.6654 0.6652
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0016 0.0161 0.0156
Onchocerca volvulus 0.0016 0.0161 0.0234
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0148 0.0215
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Onchocerca volvulus Peroxidasin homolog 0.0331 0.6654 1
Loa Loa (eye worm) hypothetical protein 0.0331 0.6654 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0215
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0015 0.0148 0.0215
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Brugia malayi Animal haem peroxidase family protein 0.0331 0.6654 1
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0331 0.6654 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1352 0.1347
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0215
Onchocerca volvulus 0.0016 0.0161 0.0234
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0059 0.0054
Schistosoma mansoni growth hormone secretagogue receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0015 0.0148 0.0215
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0733 0.0728
Echinococcus multilocularis G-protein coupled receptor, putative 0.0016 0.0161 0.0156
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0016 0.0161 0.0234
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0016 0.001
Echinococcus granulosus protein jagged 2 0.0107 0.204 0.2036
Onchocerca volvulus 0.0015 0.0148 0.0215
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0079 0.0111
Schistosoma mansoni amine GPCR 0.0016 0.0161 0.0156
Echinococcus granulosus serotonin receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Brugia malayi hypothetical protein 0.0331 0.6654 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0015 0.0148 0.0143
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0215
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0161 0.0156
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0161 0.0156
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0101 0.1906 0.1902
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0331 0.6654 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0016 0.0161 0.0156
Brugia malayi Calcium binding EGF domain containing protein 0.0107 0.204 0.3061
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0733 0.1194
Echinococcus multilocularis protein jagged 1 0.0107 0.204 0.2036
Mycobacterium tuberculosis Conserved protein 0.0043 0.0733 0.1194
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0016 0.001
Onchocerca volvulus Chorion peroxidase homolog 0.0331 0.6654 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Trypanosoma brucei cytochrome P450, putative 0.0041 0.0676 0.9125
Loa Loa (eye worm) hypothetical protein 0.0043 0.0733 0.1094
Brugia malayi Muscle positioning protein 4 0.0107 0.204 0.3061
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0015 0.0148 0.0143
Loa Loa (eye worm) beta-lactamase 0.0043 0.0733 0.1094
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0676 0.1008
Brugia malayi beta-lactamase 0.0043 0.0733 0.1094
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0015 0.0148 0.0215
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0016 0.0161 0.0156
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0016 0.0161 0.0156
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0107 0.204 0.2036
Loa Loa (eye worm) animal heme peroxidase 0.0331 0.6654 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0015 0.0148 0.0215
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0016 0.0161 0.0156
Schistosoma mansoni notch 0.0107 0.204 0.2036
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0161 0.0156
Brugia malayi Tachykinin-like peptides receptor 99D 0.0016 0.0161 0.0234
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0733 1
Echinococcus granulosus neurogenic locus notch protein 0.0107 0.204 0.2036
Loa Loa (eye worm) animal heme peroxidase 0.0331 0.6654 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0148 0.0215
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0161 0.0156
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0015 0.0148 0.0143
Loa Loa (eye worm) notch protein 0.0107 0.204 0.3061
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0161 0.0156
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0161 0.0156
Echinococcus multilocularis peroxidasin 0.0331 0.6654 0.6652
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0161 0.0156
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0015 0.0148 0.0215
Echinococcus multilocularis neural cadherin 0.0107 0.204 0.2036
Loa Loa (eye worm) hypothetical protein 0.0043 0.0733 0.1094
Onchocerca volvulus Peroxidase homolog 0.0331 0.6654 1
Schistosoma mansoni hypothetical protein 0.0016 0.0161 0.0156
Schistosoma mansoni hypothetical protein 0.0012 0.0079 0.0074
Loa Loa (eye worm) hypothetical protein 0.0015 0.0148 0.0215
Echinococcus multilocularis 0.0012 0.0079 0.0074
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0059 0.0081
Echinococcus granulosus protein jagged 2 0.0107 0.204 0.2036
Brugia malayi Cation transporter family protein 0.0015 0.0148 0.0215
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0733 0.1094
Schistosoma mansoni peroxidasin 0.0331 0.6654 0.6652
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0161 0.0156
Onchocerca volvulus 0.0331 0.6654 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0331 0.6654 1
Echinococcus granulosus neurogenic locus notch protein 4 0.0107 0.204 0.2036
Toxoplasma gondii EGF family domain-containing protein 0.0107 0.204 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Mycobacterium ulcerans lipase LipD 0.0043 0.0733 1
Echinococcus multilocularis neuropeptide s receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Loa Loa (eye worm) melatonin receptor type 1A 0.0016 0.0161 0.0234
Onchocerca volvulus 0.0016 0.0161 0.0234
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0015 0.0148 0.0143
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0015 0.0148 0.0215
Leishmania major cytochrome p450-like protein 0.0041 0.0676 0.9125
Echinococcus granulosus neurogenic locus notch protein 0.0107 0.204 0.2036
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Onchocerca volvulus 0.0016 0.0161 0.0234
Schistosoma mansoni nAChR subunit 0.0015 0.0148 0.0143
Echinococcus granulosus neuropeptide receptor A26 0.0016 0.0161 0.0156
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0161 0.0156
Schistosoma mansoni biogenic amine receptor 0.0016 0.0161 0.0156
Schistosoma mansoni cpg binding protein 0.0037 0.0593 0.0588
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Onchocerca volvulus 0.0101 0.1906 0.286
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0016 0.0161 0.0156
Brugia malayi hypothetical protein 0.0016 0.0161 0.0234
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Onchocerca volvulus 0.0016 0.0161 0.0234
Loa Loa (eye worm) animal heme peroxidase 0.0331 0.6654 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Loa Loa (eye worm) blistered cuticle protein 3 0.0331 0.6654 1
Giardia lamblia High cysteine protein 0.0107 0.204 0.5
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0015 0.0148 0.0143
Schistosoma mansoni biogenic amine receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0234
Loa Loa (eye worm) CYP4Cod1 0.0041 0.0676 0.1008
Schistosoma mansoni hypothetical protein 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0331 0.6654 1
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0676 0.9125
Schistosoma mansoni neuropeptide receptor 0.0016 0.0161 0.0156
Schistosoma mansoni neuropeptide receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0107 0.204 0.3061
Brugia malayi Cytochrome P450 family protein 0.0041 0.0676 0.1008
Loa Loa (eye worm) LGC-31 protein 0.0015 0.0148 0.0215
Loa Loa (eye worm) hypothetical protein 0.0331 0.6654 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0161 0.0156
Echinococcus multilocularis g-protein coupled receptor 0.0016 0.0161 0.0156
Schistosoma mansoni cpg binding protein 0.0037 0.0593 0.0588
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0016 0.0161 0.0234
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0161 0.0156
Echinococcus multilocularis sex peptide receptor 0.0016 0.0161 0.0156
Loa Loa (eye worm) cytochrome P450 0.0012 0.0079 0.0111
Schistosoma mansoni laminin gamma-3 chain 0.0107 0.204 0.2036
Echinococcus granulosus glycine receptor subunit beta 0.0015 0.0148 0.0143
Brugia malayi hypothetical protein 0.0016 0.0161 0.0234
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0161 0.0156
Echinococcus granulosus glycine receptor subunit beta 0.0015 0.0148 0.0143
Echinococcus multilocularis slit 2 protein 0.0107 0.204 0.2036

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 141.2538 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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