Detailed information for compound 1558472

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 484.528 | Formula: C22H24N6O5S
  • H donors: 5 H acceptors: 5 LogP: 1.27 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC[C@@H](C(=O)N[C@H](C(=O)N)Cc1c(Sc2ccccc2[N+](=O)[O-])[nH]c2c1cccc2)NC(=O)C
  • InChi: 1S/C22H24N6O5S/c1-12(29)25-17(11-23)21(31)26-16(20(24)30)10-14-13-6-2-3-7-15(13)27-22(14)34-19-9-5-4-8-18(19)28(32)33/h2-9,16-17,27H,10-11,23H2,1H3,(H2,24,30)(H,25,29)(H,26,31)/t16-,17-/m0/s1
  • InChiKey: SHIIQBSWTOVKQO-IRXDYDNUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.0039 0.0319 0.104
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0009 0.0019
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.1146 0.2877
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0021 0.011 0.0244
Plasmodium vivax hypothetical protein, conserved 0.0021 0.011 0.0102
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0407 0.1238
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.059 0.1304
Trypanosoma brucei metacaspase MCA3 0.0017 0.0071 0.0159
Schistosoma mansoni hypothetical protein 0.0331 0.3666 0.8101
Entamoeba histolytica hypothetical protein 0.0037 0.0295 0.2521
Entamoeba histolytica hypothetical protein 0.0037 0.0295 0.2521
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0592 0.1815
Brugia malayi hypothetical protein 0.0029 0.021 0.0509
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0404 0.0893
Loa Loa (eye worm) hypothetical protein 0.005 0.0446 0.1106
Loa Loa (eye worm) hypothetical protein 0.0029 0.021 0.0509
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.021 0.0509
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.061 0.1521
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Echinococcus multilocularis lysyl tRNA synthetase 0.0046 0.0407 0.0899
Loa Loa (eye worm) hypothetical protein 0.0016 0.0055 0.0118
Onchocerca volvulus 0.0029 0.021 0.2312
Schistosoma mansoni sugar transporter 0.0029 0.021 0.0464
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0319 0.1377
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0404 0.0893
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.021 0.0201
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.061 0.0602
Schistosoma mansoni caspase-7 (C14 family) 0.0017 0.0071 0.0158
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Giardia lamblia Prolyl-tRNA synthetase 0.0062 0.059 0.7917
Plasmodium vivax CDK-related protein kinase 6, putative 0.0884 1 1
Onchocerca volvulus 0.0028 0.0193 0.1926
Brugia malayi beta-lactamase family protein 0.0039 0.0319 0.0784
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0407 0.0899
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0337 0.3733 0.5636
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0487 0.1076
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0071 0.0278
Echinococcus granulosus histone acetyltransferase KAT2B 0.0273 0.3005 0.6641
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0025 0.0074
Chlamydia trachomatis lysine--tRNA ligase 0.0046 0.0407 1
Toxoplasma gondii sugar transporter ST3 0.0029 0.021 0.0304
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.059 0.1304
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0071 0.0278
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.1146 0.2532
Loa Loa (eye worm) hypothetical protein 0.0029 0.021 0.0509
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.0071 0.0095
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.054 0.1346
Loa Loa (eye worm) hypothetical protein 0.0064 0.061 0.1521
Brugia malayi Cell death protein 3 precursor 0.0057 0.053 0.1318
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0062 0.059 0.1471
Loa Loa (eye worm) hypothetical protein 0.0182 0.1963 0.4945
Brugia malayi hypothetical protein 0.0016 0.0055 0.0117
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.061 0.1521
Trypanosoma cruzi hexose transporter, putative 0.0029 0.021 0.0509
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Loa Loa (eye worm) hypothetical protein 0.0034 0.0265 0.0649
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0046 0.0407 0.1769
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0487 0.1076
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0025 0.0074
Onchocerca volvulus 0.0029 0.021 0.2312
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.056 0.1237
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0592 0.1309
Schistosoma mansoni hypothetical protein 0.0016 0.0055 0.0122
Mycobacterium tuberculosis Conserved protein 0.0039 0.0319 0.104
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0025 0.0074
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Echinococcus granulosus solute carrier family 22 0.0029 0.021 0.0464
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.021 0.0509
Echinococcus granulosus caspase 8 0.0017 0.0071 0.0158
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.005
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0487 0.121
Plasmodium falciparum proline--tRNA ligase 0.0073 0.0708 0.07
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0097 0.0223
Loa Loa (eye worm) hypothetical protein 0.0062 0.059 0.1471
Loa Loa (eye worm) hypothetical protein 0.0039 0.0319 0.0784
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0708 0.1771
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0017 0.0071 0.0158
Trypanosoma cruzi metacaspase 5, putative 0.0017 0.0071 0.0159
Loa Loa (eye worm) hypothetical protein 0.0021 0.011 0.0257
Trypanosoma brucei Metacaspase-4 0.0017 0.0071 0.0159
Echinococcus multilocularis solute carrier family 22 0.0029 0.021 0.0464
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1146 0.5053
Leishmania major hypothetical protein, conserved 0.0029 0.021 0.0509
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0218 0.5257
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.021 0.0509
Echinococcus granulosus lamin 0.0028 0.0193 0.0427
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.061 0.0602
Mycobacterium ulcerans oxidoreductase 0.0021 0.011 0.0316
Schistosoma mansoni ap endonuclease 0.0019 0.0097 0.0214
Onchocerca volvulus 0.0029 0.021 0.2312
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0218 0.0209
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0083 0.0822 0.3613
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.004 0.0088
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0319 0.0964
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.4525 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0073 0.0708 0.1059
Brugia malayi CXXC zinc finger family protein 0.0058 0.054 0.1346
Trypanosoma brucei metacaspase 5, putative 0.0017 0.0071 0.0159
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0592 0.1309
Trypanosoma brucei C-8 sterol isomerase, putative 0.0357 0.3961 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.061 0.1348
Loa Loa (eye worm) hypothetical protein 0.0039 0.0319 0.0784
Brugia malayi MAP kinase sur-1 0.0053 0.0487 0.121
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Loa Loa (eye worm) hypothetical protein 0.0029 0.021 0.0509
Echinococcus multilocularis solute carrier family 22 0.0029 0.021 0.0464
Loa Loa (eye worm) hypothetical protein 0.0021 0.011 0.0257
Trypanosoma cruzi metacaspase, putative 0.0017 0.0071 0.0159
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.021 0.0509
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0487 0.1076
Mycobacterium ulcerans beta-lactamase 0.0039 0.0319 0.0964
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.011 0.0341
Onchocerca volvulus 0.0029 0.021 0.2312
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0592 0.1815
Loa Loa (eye worm) hypothetical protein 0.0029 0.021 0.0509
Brugia malayi Sugar transporter family protein 0.0029 0.021 0.0509
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0592 0.1476
Onchocerca volvulus 0.0029 0.021 0.2312
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0055 0.0122
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0078 0.0175
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0319 0.1377
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.2259 0.4993
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0614 0.1532
Brugia malayi hypothetical protein 0.0024 0.0154 0.0368
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.1146 0.3817
Trypanosoma cruzi metacaspase 5, putative 0.0017 0.0071 0.0159
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2259 0.4993
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0097 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0025 0.0074
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0017 0.0071 0.0158
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0039 0.0327 0.1067
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0193 0.0467
Onchocerca volvulus 0.0039 0.0319 0.4839
Brugia malayi major facilitator superfamily protein 0.0029 0.021 0.0509
Loa Loa (eye worm) phosphofructokinase 0.0111 0.1146 0.2877
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0071 0.0278
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.061 0.091
Brugia malayi hypothetical protein 0.004 0.0333 0.082
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0097 0.0274
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1146 0.5053
Loa Loa (eye worm) hypothetical protein 0.0029 0.021 0.0509
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0127 0.0369
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0062 0.059 0.2583
Echinococcus granulosus dnaJ subfamily B 0.0406 0.4525 1
Echinococcus multilocularis General substrate transporter 0.0179 0.1924 0.4252
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0487 0.2125
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.011 0.0257
Schistosoma mansoni glucose transport protein 0.0208 0.2259 0.4993
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0097 0.0775
Echinococcus granulosus calcium dependent protein kinase 0.006 0.056 0.1237
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0614 0.1532
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0319 0.0704
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.1287 0.2844
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0487 0.121
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Entamoeba histolytica protein kinase, putative 0.0064 0.061 0.5287
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.061 0.1521
Schistosoma mansoni hypothetical protein 0.004 0.0333 0.0735
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.061 0.1348
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0193 0.0467
Loa Loa (eye worm) hypothetical protein 0.004 0.0333 0.082
Mycobacterium tuberculosis Possible oxidoreductase 0.0021 0.011 0.0341
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.0071 0.0095
Trichomonas vaginalis helicase, putative 0.0013 0.0025 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0071 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.021 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0319 0.0784
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0487 0.0724
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0327 0.2795
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0168 0.0404
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0081 0.0178
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0319 0.0784
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0404 0.0893
Loa Loa (eye worm) hypothetical protein 0.0029 0.021 0.0509
Loa Loa (eye worm) hypothetical protein 0.0039 0.0319 0.0784
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.004 0.0088
Mycobacterium leprae Probable lipase LipE 0.0039 0.0319 0.2725
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.1146 0.2877
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0487 0.121
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0097 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0614 0.269
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0487 0.2125
Echinococcus multilocularis musashi 0.0028 0.0193 0.0427
Trichomonas vaginalis esterase, putative 0.0039 0.0319 0.1377
Giardia lamblia Sugar-proton symporter 0.0029 0.021 0.274
Echinococcus multilocularis caspase 8 0.0017 0.0071 0.0158
Onchocerca volvulus 0.0029 0.021 0.2312
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0046 0.0407 0.3501
Schistosoma mansoni amine oxidase 0.0021 0.011 0.0244
Giardia lamblia Histone acetyltransferase GCN5 0.0076 0.0743 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0097 0.0391
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0097 0.0223
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0097 0.0088
Brugia malayi beta-lactamase family protein 0.0039 0.0319 0.0784
Trypanosoma brucei glucose transporter 2A 0.0065 0.0614 0.1532
Onchocerca volvulus 0.0058 0.054 1
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.021 0.0675
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.021 0.0464
Giardia lamblia Lysyl-tRNA synthetase 0.0046 0.0407 0.5423
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.061 0.1348
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.061 0.0602
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0017 0.0071 0.0158
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0071 0.0278
Onchocerca volvulus 0.0029 0.021 0.2312
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0127 0.2978
Trypanosoma cruzi glucose transporter, putative 0.0029 0.021 0.0509
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0154 0.0368
Loa Loa (eye worm) hypothetical protein 0.0021 0.011 0.0257
Brugia malayi major facilitator superfamily protein 0.0029 0.021 0.0509
Onchocerca volvulus 0.0029 0.021 0.2312
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0218 0.093
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.2259 0.4993
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.061 0.0602
Trypanosoma brucei glucose transporter, putative 0.0065 0.0614 0.1532
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0081 0.0178
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0218 0.1841
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.021 1
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0614 0.269
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.061 0.091
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0614 0.1532
Leishmania major metacaspase, putative 0.0017 0.0071 0.0159
Onchocerca volvulus Putative transporter 0.0029 0.021 0.2312
Echinococcus multilocularis solute carrier family 22 0.0029 0.021 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0071 0.0278
Leishmania major glucose transporter, lmgt2 0.0065 0.0614 0.1532
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.061 0.091
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0127 0.1042
Loa Loa (eye worm) hypothetical protein 0.0029 0.021 0.0509
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1146 1
Brugia malayi hypothetical protein 0.0021 0.011 0.0257
Trypanosoma brucei glucose transporter, putative 0.0065 0.0614 0.1532
Echinococcus multilocularis protoporphyrinogen oxidase 0.0021 0.011 0.0244
Onchocerca volvulus 0.004 0.0333 0.5171
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.021 0.0626
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Echinococcus granulosus geminin 0.0331 0.3666 0.8101
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.061 0.0602
Onchocerca volvulus 0.0029 0.021 0.2312
Loa Loa (eye worm) hypothetical protein 0.0039 0.0319 0.0784
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.061 0.1348
Schistosoma mansoni ap endonuclease 0.0019 0.0097 0.0214
Onchocerca volvulus 0.0029 0.021 0.2312
Schistosoma mansoni caspase-3 (C14 family) 0.0017 0.0071 0.0158
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0404 0.0893
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0614 0.269
Brugia malayi 6-phosphofructokinase 0.0111 0.1146 0.2877
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0337 0.3733 0.3727
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0097 0.0296
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0218 0.093
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0487 0.121
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.021 0.0304
Brugia malayi hypothetical protein 0.0029 0.021 0.0509
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0218 0.093
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0218 0.2851
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0208 0.2259 0.4993
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.1146 0.3537
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0319 0.0964
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0357 0.3961 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0292 0.3224 1
Schistosoma mansoni hypothetical protein 0.0037 0.0295 0.0653
Plasmodium vivax sugar transporter, putative 0.0029 0.021 0.0201
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0154 0.022
Brugia malayi beta-lactamase 0.0039 0.0319 0.0784
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0025 0.0074
Schistosoma mansoni cpg binding protein 0.0061 0.0578 0.1278
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.021 0.0464
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0081 0.0182
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2259 0.4993
Loa Loa (eye worm) hypothetical protein 0.0029 0.021 0.0509
Loa Loa (eye worm) hypothetical protein 0.0046 0.0407 0.1007
Onchocerca volvulus 0.0039 0.0319 0.4839
Loa Loa (eye worm) hypothetical protein 0.0029 0.021 0.0509
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0046 0.0407 0.1007
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0097 0.0391
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Plasmodium falciparum mitogen-activated protein kinase 2 0.0337 0.3733 0.3727
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0055 0.0122
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.021 0.0626
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.021 0.0464
Loa Loa (eye worm) hypothetical protein 0.0021 0.011 0.0257
Echinococcus granulosus solute carrier family 22 0.0029 0.021 0.0464
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0708 0.1771
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0327 0.1067
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0487 0.2125
Echinococcus multilocularis lamin 0.0028 0.0193 0.0427
Schistosoma mansoni cpg binding protein 0.0061 0.0578 0.1278
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.1146 0.2532
Trypanosoma brucei glucose transporter, putative 0.0065 0.0614 0.1532
Brugia malayi amine oxidase, flavin-containing family protein 0.0021 0.011 0.0257
Trypanosoma brucei glucose transporter, putative 0.0065 0.0614 0.1532
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.011 0.0244
Echinococcus multilocularis GPCR, family 2 0.0016 0.0055 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0025 0.0074
Echinococcus multilocularis 0.0021 0.011 0.0244
Trypanosoma brucei glucose transporter, putative 0.0065 0.0614 0.1532
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0319 0.104
Trichomonas vaginalis glucose transporter, putative 0.0029 0.021 0.0894
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0062 0.059 0.1471
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0319 0.104
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0071 0.0278
Toxoplasma gondii exonuclease III APE 0.0019 0.0097 0.0133
Trypanosoma cruzi hexose transporter 0.0065 0.0614 0.1532
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0614 0.269
Schistosoma mansoni hypothetical protein 0.0016 0.0055 0.0122
Loa Loa (eye worm) hypothetical protein 0.0029 0.021 0.0509
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0218 0.5257
Mycobacterium ulcerans sugar transporter 0.0029 0.021 0.0626
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0292 0.3224 1
Brugia malayi acetyltransferase, GNAT family protein 0.0281 0.3095 0.7811
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0319 0.104
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0708 0.1771
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0083 0.0822 0.0814
Trypanosoma brucei metacaspase MCA2 0.0017 0.0071 0.0159
Plasmodium falciparum lysine--tRNA ligase 0.0046 0.0407 0.0398
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.021 0.0509
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0017 0.0071 0.0159
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.1146 1
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0592 0.0883
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0319 0.0704
Loa Loa (eye worm) hypothetical protein 0.0039 0.0319 0.0784
Plasmodium vivax hypothetical protein, conserved 0.0021 0.011 0.0102
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0279 0.0683
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0055 0.0122
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.061 0.1348
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0487 0.1076
Onchocerca volvulus 0.0029 0.021 0.2312
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0218 0.0317
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.021 0.0894
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0021 0.011 0.0244
Schistosoma mansoni hypothetical protein 0.0406 0.4525 1
Echinococcus granulosus lysyl tRNA synthetase 0.0046 0.0407 0.0899
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0319 0.1377
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0487 0.121
Loa Loa (eye worm) hypothetical protein 0.0029 0.021 0.0509
Loa Loa (eye worm) hypothetical protein 0.0357 0.3961 1
Trypanosoma brucei glucose transporter 1E 0.0065 0.0614 0.1532
Schistosoma mansoni lamin 0.0028 0.0193 0.0427
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0097 0.0223
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0071 0.0278
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.021 0.0464
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0035
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.021 0.0509
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.2531 0.6383
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0487 0.2125
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0446 0.1106
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0024 0.0151 0.0215
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0046 0.0407 0.1007
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0009 0.0019
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.021 0.0626
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1146 0.5053
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0025 0.0074
Echinococcus granulosus intermediate filament protein 0.0028 0.0193 0.0427
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0708 0.1771
Leishmania major glucose transporter, lmgt3 0.0065 0.0614 0.1532
Trypanosoma brucei sugar transporter, putative 0.0029 0.021 0.0509
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0319 0.031
Echinococcus granulosus solute carrier family 22 0.0029 0.021 0.0464
Schistosoma mansoni caspase-7 (C14 family) 0.0057 0.053 0.117
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0021 0.011 0.0316
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.061 0.1521
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Mycobacterium ulcerans monoamine oxidase 0.0021 0.011 0.0316
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.1146 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0319 0.104
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0021 0.011 0.0894
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0028 0.0063
Mycobacterium ulcerans lipase LipD 0.0039 0.0319 0.0964
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.1347 0.3386
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.004 0.0088
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.021 0.0675
Onchocerca volvulus 0.0029 0.021 0.2312
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.021 0.0894
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0025 0.0074
Leishmania major glucose transporter, lmgt1 0.0065 0.0614 0.1532
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0487 0.121
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0248 0.2711 0.9071
Trypanosoma cruzi metacaspase, putative 0.0017 0.0071 0.0159
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0319 0.104
Echinococcus granulosus caspase 2 0.0057 0.053 0.117
Plasmodium vivax proline--tRNA ligase, putative 0.0073 0.0708 0.07
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0083 0.0822 0.123
Brugia malayi lysyl-tRNA synthetase 0.0046 0.0407 0.1007
Brugia malayi follicle stimulating hormone receptor 0.0232 0.2531 0.6383
Schistosoma mansoni protein kinase 0.0064 0.061 0.1348
Plasmodium falciparum metacaspase-like protein 0.0017 0.0071 0.0063
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0055 0.0118
Leishmania major hypothetical protein, conserved 0.0024 0.0154 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0025 0.0074
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0071 0.0278
Onchocerca volvulus 0.0029 0.021 0.2312
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0614 0.269
Plasmodium falciparum histone acetyltransferase GCN5 0.0076 0.0743 0.0735
Brugia malayi SWIRM domain containing protein 0.0021 0.011 0.0257
Entamoeba histolytica hypothetical protein 0.0037 0.0295 0.2521
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0154 0.0146
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0055 0.0118
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0035
Onchocerca volvulus 0.0029 0.021 0.2312
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0062 0.059 0.5111
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0319 0.0704
Echinococcus granulosus GPCR family 2 0.0016 0.0055 0.0122
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0097 0.0223
Loa Loa (eye worm) hypothetical protein 0.0027 0.0187 0.0452
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0025 0.0074
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Schistosoma mansoni amine oxidase 0.0021 0.011 0.0244
Plasmodium falciparum hexose transporter 0.0208 0.2259 0.2252
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0097 0.12
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0404 0.0893
Echinococcus granulosus solute carrier family 22 0.0029 0.021 0.0464
Loa Loa (eye worm) hypothetical protein 0.0057 0.053 0.1318
Plasmodium falciparum protein kinase 7 0.0589 0.6617 0.6614
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2259 0.4993
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.1146 0.2877
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0009 0.0019
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0319 0.0784
Schistosoma mansoni hypothetical protein 0.0034 0.0265 0.0586
Leishmania major UDP-galactopyranose mutase 0.0021 0.011 0.0257
Brugia malayi Cam kinase protein 1 0.0064 0.061 0.1521
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0071 0.0278
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0272 0.2988 1
Echinococcus granulosus cpg binding protein 0.0061 0.0578 0.1278
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0097 0.0223
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.021 0.0464
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.004 0.0088
Schistosoma mansoni protein kinase 0.0064 0.061 0.1348
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0045 0.0093
Echinococcus multilocularis caspase 0.0017 0.0071 0.0158
Trypanosoma brucei glucose transporter, putative 0.0065 0.0614 0.1532
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.021 0.0509
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.061 0.1348
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0281 0.3095 0.6841
Loa Loa (eye worm) hypothetical protein 0.0029 0.021 0.0509
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0446 0.1106
Trypanosoma brucei protein kinase, putative 0.0053 0.0487 0.121
Loa Loa (eye worm) hypothetical protein 0.0021 0.011 0.0257
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0708 0.1771
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0159
Loa Loa (eye worm) hypothetical protein 0.0029 0.021 0.0509
Toxoplasma gondii histone lysine-specific demethylase 0.0021 0.011 0.0154
Mycobacterium tuberculosis Conserved protein 0.0039 0.0319 0.104
Loa Loa (eye worm) sugar transporter 0.0029 0.021 0.0509
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.061 0.2671
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0218 0.0209
Onchocerca volvulus 0.0028 0.0193 0.1926
Loa Loa (eye worm) sugar transporter 0.0208 0.2259 0.5694
Loa Loa (eye worm) hypothetical protein 0.0021 0.011 0.0257
Mycobacterium ulcerans hypothetical protein 0.0039 0.0319 0.0964
Entamoeba histolytica protein kinase, putative 0.0064 0.061 0.5287
Leishmania major hypothetical protein, conserved 0.0039 0.0319 0.0784
Echinococcus multilocularis geminin 0.0331 0.3666 0.8101
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.061 0.0602
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0218 0.0317
Schistosoma mansoni hypothetical protein 0.0016 0.0055 0.0122
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0446 0.1106
Schistosoma mansoni hypothetical protein 0.0016 0.0055 0.0122
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0045 0.0093
Echinococcus multilocularis lamin dm0 0.0028 0.0193 0.0427
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0071 0.0278
Echinococcus granulosus caspase 0.0017 0.0071 0.0158
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0218 0.0209
Plasmodium vivax hexose transporter 0.0208 0.2259 0.2252
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0083 0.0822 0.123
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0025 0.0074
Loa Loa (eye worm) acetyltransferase 0.0281 0.3095 0.7811
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.1347 0.3386
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0218 0.0317
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0592 0.1815
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0592 0.1309
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0319 0.104
Entamoeba histolytica hypothetical protein 0.0046 0.0407 0.3501
Trichomonas vaginalis bromodomain-containing protein, putative 0.0083 0.0822 0.3613
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0097 0.0214
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.011 0.0244
Loa Loa (eye worm) hypothetical protein 0.0062 0.059 0.1471
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0193 0.0467
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0319 0.0784
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0025 0.0074
Brugia malayi MH2 domain containing protein 0.0128 0.1347 0.3386
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.0333 0.0735
Plasmodium vivax lysine--tRNA ligase, putative 0.0046 0.0407 0.0398
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.1146 0.2877
Schistosoma mansoni sugar transporter 0.0029 0.021 0.0464
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0062 0.059 0.1304
Onchocerca volvulus 0.0039 0.0319 0.4839
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0154 0.0146
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.0071 0.0095
Toxoplasma gondii facilitative glucose transporter GT1 0.0208 0.2259 0.3405
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0295 0.0653
Toxoplasma gondii sugar transporter ST2 0.0029 0.021 0.0304
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.011 0.0102
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.061 0.0602
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0218 0.1841
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.061 0.1348
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0614 0.269
Brugia malayi phosphofructokinase 0.0111 0.1146 0.2877
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0218 0.0209
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0404 0.1
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.2259 1
Schistosoma mansoni cpg binding protein 0.0058 0.054 0.1194
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0407 0.1238
Trypanosoma cruzi metacaspase, putative 0.0017 0.0071 0.0159
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0592 0.1958
Echinococcus granulosus histone acetyltransferase KAT2B 0.0083 0.0822 0.1816
Schistosoma mansoni hypothetical protein 0.0331 0.3666 0.8101
Schistosoma mansoni intermediate filament proteins 0.0028 0.0193 0.0427
Onchocerca volvulus 0.0029 0.021 0.2312
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0319 0.0704
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0154 0.0146
Schistosoma mansoni lamin 0.0028 0.0193 0.0427
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0487 0.1076
Plasmodium vivax metacaspase 1, putative 0.0017 0.0071 0.0063
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0021 0.011 0.0102
Loa Loa (eye worm) hypothetical protein 0.0051 0.0456 0.1131
Chlamydia trachomatis protoporphyrinogen oxidase 0.0021 0.011 0.2555
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0487 0.121
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0614 0.1532
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0319 0.1377
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0319 0.0784
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1146 0.5053
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0265 0.0649
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.061 0.1348
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.0333 0.0735
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0062 0.059 0.1304
Entamoeba histolytica hypothetical protein 0.0037 0.0295 0.2521
Trypanosoma brucei metacaspase 0.0017 0.0071 0.0159
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0055 0.0122
Loa Loa (eye worm) hypothetical protein 0.0039 0.0319 0.0784
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.021 0.0894
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0341 0.1477
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0407 0.0899
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0025 0.0074
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.011 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.021 0.0894
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0071 0.0063
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0062 0.059 0.5111
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0021 0.011 0.0102
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0319 0.2725
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0614 0.269
Trypanosoma cruzi sugar transporter, putative 0.0029 0.021 0.0509
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.004 0.0088
Loa Loa (eye worm) hypothetical protein 0.0029 0.021 0.0509
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0154 0.0368
Brugia malayi hypothetical protein 0.0029 0.021 0.0509
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.061 0.1348
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0097 0.0223
Schistosoma mansoni sugar transporter 0.0029 0.021 0.0464
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0021 0.011 0.0102
Echinococcus granulosus lamin dm0 0.0028 0.0193 0.0427
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.061 0.0602
Loa Loa (eye worm) hypothetical protein 0.0024 0.0154 0.0368
Onchocerca volvulus Cell death protein 3 homolog 0.0057 0.053 0.9747
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0404 0.0893
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1146 1
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.1146 0.2532
Mycobacterium ulcerans dehydrogenase 0.0021 0.011 0.0316
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0487 0.6513
Plasmodium falciparum protoporphyrinogen oxidase 0.0021 0.011 0.0102
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.061 0.0602
Toxoplasma gondii lysine-tRNA ligase 0.0046 0.0407 0.0602
Brugia malayi 6-phosphofructokinase 0.0111 0.1146 0.2877
Toxoplasma gondii sugar transporter ST1 0.0029 0.021 0.0304
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0097 0.0775
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.021 0.0894
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0487 0.121
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0218 0.093
Toxoplasma gondii protein kinase, putative 0.0589 0.6617 1
Leishmania major C-8 sterol isomerase-like protein 0.0357 0.3961 1
Schistosoma mansoni hypothetical protein 0.0208 0.2259 0.4993
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.1215 0.1826
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2259 0.4993
Schistosoma mansoni glucose transporter 0.0029 0.021 0.0464
Loa Loa (eye worm) beta-lactamase 0.0039 0.0319 0.0784
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0319 0.104
Schistosoma mansoni glucose transport protein 0.0208 0.2259 0.4993
Echinococcus multilocularis caspase 2 0.0057 0.053 0.117
Loa Loa (eye worm) hypothetical protein 0.0028 0.0193 0.0467
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0097 0.438
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0218 0.093
Leishmania major protein kinase, putative 0.0064 0.061 0.1521
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0028 0.0063
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0071 0.0278
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0009 0.0019
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.1146 0.2877
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0614 0.1532
Brugia malayi intermediate filament protein 0.0028 0.0193 0.0467
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1146 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0218 0.093
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0281 0.3095 0.6841
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0071 0.0278
Entamoeba histolytica acetyltransferase, GNAT family 0.0076 0.0743 0.6456
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Brugia malayi Sugar transporter family protein 0.0208 0.2259 0.5694
Schistosoma mansoni protein kinase 0.0064 0.061 0.1348
Onchocerca volvulus 0.0029 0.021 0.2312
Giardia lamblia Hexose transporter 0.0029 0.021 0.274
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0404 0.1
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0614 0.1532
Trichomonas vaginalis sugar transporter, putative 0.0029 0.021 0.0894
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0071 0.0278
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.1146 0.2532
Schistosoma mansoni glucose transport protein 0.0208 0.2259 0.4993
Brugia malayi Sugar transporter family protein 0.0029 0.021 0.0509
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0295 0.0653
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0025 0.0074
Trypanosoma brucei glucose transporter, putative 0.0065 0.0614 0.1532
Echinococcus multilocularis solute carrier family 22 0.0029 0.021 0.0464
Trypanosoma brucei glucose transporter, putative 0.0065 0.0614 0.1532
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0071 0.0278
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0025 0.0074
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0357 0.3961 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0025 0.0074
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.2259 0.4993
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0154 0.0368
Loa Loa (eye worm) hypothetical protein 0.0029 0.021 0.0509
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0025 0.0074
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.021 0.0894
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0021 0.011 0.0244
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0055 0.0118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0404 0.0893
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0009 0.0019
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0319 0.1377
Echinococcus multilocularis cpg binding protein 0.0061 0.0578 0.1278
Schistosoma mansoni sugar transporter 0.0029 0.021 0.0464
Leishmania major lysyl-tRNA synthetase, putative 0.0046 0.0407 0.1007
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0218 0.093
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0295 0.0653
Plasmodium falciparum metacaspase 1 0.0017 0.0071 0.0063
Toxoplasma gondii ABC1 family protein 0.0039 0.0319 0.0469
Trypanosoma cruzi metacaspase, putative 0.0017 0.0071 0.0159
Brugia malayi hypothetical protein 0.0037 0.0295 0.0725
Echinococcus granulosus General substrate transporter 0.0179 0.1924 0.4252
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0592 0.1309
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0614 0.1532

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 14.6 % Blockade of rat recombinant TRPV1 expressed in xenopus oocytes assessed as inhibition of capsaicin-induced whole-cell current at 10 uM at holding potential of -60 mV by by electrophysiological assay relative to control ChEMBL. 21612926
Inhibition (binding) = 27 % Blockade of human recombinant NR1/NR2A expressed in xenopus oocytes assessed as inhibition of L-glutamate/glycine-induced whole-cell current at 10 uM at holding potential of -60 mV by by electrophysiological assay relative to control ChEMBL. 21612926

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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