TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 491.559 | Formula: C26H25N3O5S
H donors: 0 H acceptors: 4 LogP: 2.23 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)[C@]1(C)N2C(=NC[C@@H]2[C@H]2[C@@H]1C(=O)N(C2=O)Cc1ccccc1)SCC(=O)c1ccccc1
InChi: 1S/C26H25N3O5S/c1-26(24(33)34-2)21-20(22(31)28(23(21)32)14-16-9-5-3-6-10-16)18-13-27-25(29(18)26)35-15-19(30)17-11-7-4-8-12-17/h3-12,18,20-21H,13-15H2,1-2H3/t18-,20+,21-,26-/m1/s1
InChiKey: DTGWNBRCVSUUON-PJGVWAEBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1113	1	1
Schistosoma mansoni	chromobox protein	0.003	0.02	0.0178
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0055	0.0428	0.1325
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0011	0.0025	0.0084
Schistosoma mansoni	glycogen phosphorylase	0.0129	0.11	0.108
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1113	1	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0069	0.0557	0.4966
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0055	0.0428	0.0407
Brugia malayi	EGF-like domain containing protein	0.0061	0.0481	0.0481
Onchocerca volvulus		0.0028	0.0186	0.0532
Trichomonas vaginalis	importin beta-1, putative	0.0018	0.0091	0.0252
Onchocerca volvulus		0.0061	0.0481	0.1674
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0055	0.0428	0.0407
Brugia malayi	EGF-like domain containing protein	0.0061	0.0481	0.0481
Echinococcus multilocularis	neurogenic locus notch protein	0.0061	0.0481	0.0461
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0011	0.0025	0.0074
Leishmania major	trypanothione reductase	0.003	0.0205	0.4507
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0055	0.0428	0.0407
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0055	0.0428	0.0407
Trypanosoma cruzi	MFS transporter, putative	0.0028	0.0186	0.4044
Brugia malayi	sodium-independent organic anion transporter family protein	0.0028	0.0186	0.0186
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0055	0.0428	0.0407
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0011	0.0025	0.0084
Echinococcus multilocularis	protein jagged 1	0.0061	0.0481	0.0461
Schistosoma mansoni	hypothetical protein	0.0061	0.0481	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0011	0.0025	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Echinococcus multilocularis	follistatin	0.0019	0.0105	0.0083
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0055	0.0428	1
Echinococcus granulosus	glycogen phosphorylase	0.0299	0.2635	0.2619
Onchocerca volvulus		0.0055	0.0428	0.1467
Echinococcus multilocularis	neural cadherin	0.0061	0.0481	0.0461
Echinococcus multilocularis	notch	0.0061	0.0481	0.0461
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0018	0.0091	0.0252
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0011	0.0025	0.0186
Schistosoma mansoni	notch	0.0061	0.0481	0.0461
Onchocerca volvulus	Putative organic anion transporter	0.0028	0.0186	0.0532
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0055	0.0428	0.0407
Treponema pallidum	NADH oxidase	0.0011	0.0025	0.5
Onchocerca volvulus		0.0055	0.0428	0.1467
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0234	0.2049	0.2031
Onchocerca volvulus		0.0055	0.0428	0.1467
Trichomonas vaginalis	chromobox protein, putative	0.003	0.02	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1637	0.1618
Onchocerca volvulus	Putative organic anion transporter	0.0028	0.0186	0.0532
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0069	0.0557	0.4966
Onchocerca volvulus		0.0055	0.0428	0.1467
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0328	0.0307
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0055	0.0428	0.0428
Echinococcus granulosus	protein jagged 2	0.0061	0.0481	0.0461
Echinococcus granulosus	chromobox protein 1	0.003	0.02	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Onchocerca volvulus		0.0028	0.0186	0.0532
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0077	0.0627	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0018	0.0091	0.0252
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0055	0.0428	0.1325
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Schistosoma mansoni	septate junction protein	0.0061	0.0481	0.0461
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0011	0.0025	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Onchocerca volvulus	Peroxidasin homolog	0.0189	0.1637	0.614
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0055	0.0428	0.0407
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0055	0.0428	0.0407
Schistosoma mansoni	protein tyrosine phosphatase	0.0055	0.0428	0.0407
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0055	0.0428	0.0407
Schistosoma mansoni	hypothetical protein	0.0234	0.2049	0.2031
Brugia malayi	Calcium binding EGF domain containing protein	0.0061	0.0481	0.0481
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0055	0.0428	0.0407
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Onchocerca volvulus		0.0055	0.0428	0.1467
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0105	0.0083
Loa Loa (eye worm)	notch protein	0.0061	0.0481	0.0461
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0055	0.0428	0.0407
Onchocerca volvulus	Peroxidasin homolog	0.0189	0.1637	0.614
Schistosoma mansoni	peroxidasin	0.0189	0.1637	0.1618
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0055	0.0428	0.0407
Onchocerca volvulus		0.0055	0.0428	0.1467
Brugia malayi	Peroxidasin	0.0189	0.1637	0.1637
Loa Loa (eye worm)	animal heme peroxidase	0.0189	0.1637	0.1618
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0129	0.11	1
Schistosoma mansoni	notch	0.0061	0.0481	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0129	0.11	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0055	0.0428	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1637	0.1618
Onchocerca volvulus		0.0055	0.0428	0.1467
Brugia malayi	EGF-like domain containing protein	0.0061	0.0481	0.0481
Echinococcus multilocularis	neurogenic locus protein delta	0.0061	0.0481	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0011	0.0025	0.0186
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0055	0.0428	0.1325
Loa Loa (eye worm)	transcription factor SMAD2	0.0051	0.0392	0.0371
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0055	0.0428	0.0407
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0019	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0055	0.0428	0.0407
Schistosoma mansoni	hypothetical protein	0.0061	0.0481	0.0461
Schistosoma mansoni	hypothetical protein	0.0061	0.0481	0.0461
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0011	0.0025	0.0084
Brugia malayi	hypothetical protein	0.0028	0.0186	0.0186
Brugia malayi	EGF-like domain containing protein	0.0061	0.0481	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Echinococcus granulosus	delta-like protein 1	0.0061	0.0481	0.0461
Onchocerca volvulus		0.0038	0.0274	0.0871
Brugia malayi	Animal haem peroxidase family protein	0.0189	0.1637	0.1637
Trichomonas vaginalis	chromobox protein, putative	0.003	0.02	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0018	0.0091	0.1701
Onchocerca volvulus		0.0189	0.1637	0.614
Trypanosoma cruzi	trypanothione reductase, putative	0.0011	0.0025	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Echinococcus granulosus	follistatin	0.0019	0.0105	0.0083
Brugia malayi	Blistered cuticle protein 3	0.0189	0.1637	0.1637
Loa Loa (eye worm)	glycogen phosphorylase	0.0299	0.2635	0.2619
Brugia malayi	chromobox protein homolog 3	0.0017	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1637	0.1618
Toxoplasma gondii	NADPH-glutathione reductase	0.0011	0.0025	0.0074
Echinococcus multilocularis	geminin	0.0394	0.3496	0.3482
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0055	0.0428	0.0407
Echinococcus multilocularis	slit 2 protein	0.0061	0.0481	0.0461
Echinococcus multilocularis	neurogenic locus protein delta	0.0061	0.0481	0.0461
Echinococcus granulosus	protein jagged 1	0.0061	0.0481	0.0461
Onchocerca volvulus		0.0189	0.1637	0.614
Brugia malayi	carbohydrate phosphorylase	0.0299	0.2635	0.2635
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.003	0.0205	0.1698
Loa Loa (eye worm)	animal heme peroxidase	0.0189	0.1637	0.1618
Onchocerca volvulus	Slit protein homolog	0.0061	0.0481	0.1674
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0055	0.0428	0.0407
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0055	0.0428	0.0407
Echinococcus granulosus	fibropellin Ia	0.0061	0.0481	0.0461
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0055	0.0428	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0055	0.0428	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Onchocerca volvulus		0.0061	0.0481	0.1674
Giardia lamblia	Protein tyrosine phosphatase	0.0055	0.0428	0.1543
Brugia malayi	glutathione reductase	0.003	0.0205	0.0205
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0055	0.0428	0.0407
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0011	0.0025	0.5
Echinococcus granulosus	glycogen phosphorylase	0.0299	0.2635	0.2619
Echinococcus multilocularis	protein jagged 2	0.0061	0.0481	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1637	0.1618
Brugia malayi	Protein-tyrosine phosphatase 1	0.0055	0.0428	0.0428
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0055	0.0428	0.0407
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0055	0.0428	0.0407
Brugia malayi	GCC2 and GCC3 family protein	0.0061	0.0481	0.0481
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0055	0.0428	0.0407
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.0028	0.0186	0.0165
Schistosoma mansoni	notch	0.0061	0.0481	0.0461
Schistosoma mansoni	hypothetical protein	0.0394	0.3496	0.3482
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Brugia malayi	Protein-tyrosine phosphatase	0.0055	0.0428	0.0428
Loa Loa (eye worm)	blistered cuticle protein 3	0.0189	0.1637	0.1618
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0019	0.0105	0.1806
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0061	0.0481	0.0461
Schistosoma mansoni	chromobox protein	0.003	0.02	0.0178
Entamoeba histolytica	glycogen phosphorylase, putative	0.0129	0.11	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Loa Loa (eye worm)	heterochromatin protein 1	0.003	0.02	0.0178
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0077	0.0627	0.5615
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0186	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Onchocerca volvulus		0.0055	0.0428	0.1467
Entamoeba histolytica	glycogen phosphorylase, putative	0.0299	0.2635	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Onchocerca volvulus	Dual oxidase homolog	0.0189	0.1637	0.614
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0011	0.0025	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0274	0.0252
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0055	0.0428	0.0407
Brugia malayi	notch-like transmembrane receptor	0.0061	0.0481	0.0481
Echinococcus multilocularis	hypothetical protein	0.0055	0.0428	0.0407
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0019	0.0105	0.1806
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0105	0.0083
Brugia malayi	Protein-tyrosine phosphatase	0.0055	0.0428	0.0428
Mycobacterium tuberculosis	Probable oxidoreductase	0.0077	0.0627	0.5615
Schistosoma mansoni	notch	0.0061	0.0481	0.0461
Plasmodium vivax	glutathione reductase, putative	0.003	0.0205	1
Brugia malayi	secreted modular calcium-binding protein 1	0.0019	0.0105	0.0105
Loa Loa (eye worm)	MH2 domain-containing protein	0.0051	0.0392	0.0371
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0055	0.0428	0.0407
Schistosoma mansoni	hypothetical protein	0.0394	0.3496	0.3482
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1637	0.1618
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0055	0.0428	0.0407
Echinococcus granulosus	agrin	0.0019	0.0105	0.0083
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0061	0.0481	0.0461
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0055	0.0428	1
Onchocerca volvulus		0.0055	0.0428	0.1467
Schistosoma mansoni	organic anion transporter	0.0028	0.0186	0.0165
Echinococcus multilocularis	snurportin 1	0.0234	0.2049	0.2031
Brugia malayi	Calcium binding EGF domain containing protein	0.0061	0.0481	0.0481
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0019	0.0105	0.0105
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0055	0.0428	0.0407
Mycobacterium tuberculosis	Probable dehydrogenase	0.0069	0.0557	0.4966
Echinococcus multilocularis	glycogen phosphorylase	0.0299	0.2635	0.2619
Schistosoma mansoni	cell polarity protein	0.0061	0.0481	0.0461
Giardia lamblia	Glycogen phosphorylase	0.0299	0.2635	1
Brugia malayi	Delta serrate ligand family protein	0.0061	0.0481	0.0481
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0055	0.0428	0.0407
Onchocerca volvulus	Peroxidase homolog	0.0189	0.1637	0.614
Toxoplasma gondii	EGF family domain-containing protein	0.0061	0.0481	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0055	0.0428	0.0407
Brugia malayi	Isocitrate dehydrogenase	0.001	0.0022	0.0022
Schistosoma mansoni	importin beta-1	0.0022	0.0128	0.0107
Onchocerca volvulus		0.0055	0.0428	0.1467
Entamoeba histolytica	glycogenphosphorylase, putative	0.0129	0.11	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0274	0.0252
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0011	0.0025	0.0084
Loa Loa (eye worm)	Notch2	0.0061	0.0481	0.0461
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Echinococcus granulosus	chromobox protein 1	0.003	0.02	0.0178
Schistosoma mansoni	notch	0.0061	0.0481	0.0461
Echinococcus multilocularis	agrin	0.0019	0.0105	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Schistosoma mansoni	pcd6 interacting protein-related	0.0055	0.0428	0.0407
Echinococcus granulosus	neurogenic locus notch protein	0.0061	0.0481	0.0461
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0055	0.0428	0.0407
Echinococcus multilocularis	chromobox protein 1	0.003	0.02	0.0178
Echinococcus multilocularis	neurogenic locus notch protein	0.0061	0.0481	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0055	0.0428	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1637	0.1618
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0055	0.0428	0.0407
Plasmodium falciparum	glutathione reductase	0.0011	0.0025	0.0186
Schistosoma mansoni	hypothetical protein	0.0061	0.0481	0.0461
Loa Loa (eye worm)	animal heme peroxidase	0.0189	0.1637	0.1618
Echinococcus multilocularis	chromobox protein 1	0.003	0.02	0.0178
Echinococcus multilocularis	fibropellin Ia	0.0061	0.0481	0.0461
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0011	0.0025	0.0084
Chlamydia trachomatis	glycogen phosphorylase	0.0299	0.2635	1
Giardia lamblia	High cysteine protein	0.0061	0.0481	0.1748
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0055	0.0428	0.0407
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0055	0.0428	0.0407
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0011	0.0025	0.0084
Echinococcus granulosus	neurogenic locus protein delta	0.0061	0.0481	0.0461
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0011	0.0025	0.0084
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0081	0.0214
Schistosoma mansoni	notch	0.0061	0.0481	0.0461
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0011	0.0025	0.0186
Onchocerca volvulus		0.0055	0.0428	0.1467
Trypanosoma brucei	importin beta-1 subunit, putative	0.0022	0.0128	0.2625
Onchocerca volvulus	Peroxidase homolog	0.0189	0.1637	0.614
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0055	0.0428	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1637	0.1618
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0055	0.0428	0.0407
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Schistosoma mansoni	hypothetical protein	0.0061	0.0481	0.0461
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0069	0.0557	0.4966
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0055	0.0428	0.0407
Brugia malayi	hypothetical protein	0.0028	0.0186	0.0186
Brugia malayi	isocitrate dehydrogenase	0.001	0.0022	0.0022
Echinococcus granulosus	geminin	0.0394	0.3496	0.3482
Echinococcus granulosus	importin subunit beta 1	0.0022	0.0128	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1637	0.1618
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0055	0.0428	0.0407
Brugia malayi	Animal haem peroxidase family protein	0.0189	0.1637	0.1637
Loa Loa (eye worm)	agrin synaptic family protein	0.0019	0.0105	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0299	0.2635	1
Onchocerca volvulus		0.0055	0.0428	0.1467
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0055	0.0428	0.0407
Brugia malayi	Muscle positioning protein 4	0.0061	0.0481	0.0481
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0055	0.0428	0.0407
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.0019	0.0105	0.0083
Onchocerca volvulus		0.0055	0.0428	0.1467
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0055	0.0428	0.0407
Schistosoma mansoni	glycogen phosphorylase	0.0299	0.2635	0.2619
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0055	0.0428	0.0407
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0019	0.0105	0.0105
Echinococcus granulosus	Glycosyl transferase family 35	0.0299	0.2635	0.2619
Loa Loa (eye worm)	glutathione reductase	0.003	0.0205	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Echinococcus granulosus	neurogenic locus notch protein 4	0.0061	0.0481	0.0461
Schistosoma mansoni	protein tyrosine phosphatase	0.0055	0.0428	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Brugia malayi	Animal haem peroxidase family protein	0.0189	0.1637	0.1637
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0299	0.2635	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0055	0.0428	0.0407
Schistosoma mansoni	peroxidasin	0.0189	0.1637	0.1618
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0521	0.4644	0.4633
Onchocerca volvulus		0.0028	0.0186	0.0532
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0055	0.0428	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1113	1	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0055	0.0428	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0186	0.0165
Brugia malayi	Importin beta-1 subunit	0.0022	0.0128	0.0128
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0055	0.0428	0.0407
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0011	0.0025	0.0084
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Echinococcus granulosus	neural cadherin	0.0061	0.0481	0.0461
Onchocerca volvulus		0.0061	0.0481	0.1674
Brugia malayi	RNA, U transporter 1	0.0062	0.0494	0.0494
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0037	0.0045
Onchocerca volvulus	Chorion peroxidase homolog	0.0189	0.1637	0.614
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0019	0.0105	0.1806
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0055	0.0428	0.0407
Onchocerca volvulus		0.0055	0.0428	0.1467
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1637	0.1618
Plasmodium falciparum	thioredoxin reductase	0.0011	0.0025	0.0186
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0011	0.0025	0.0186
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0055	0.0428	0.0407
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0055	0.0428	0.0407
Schistosoma mansoni	laminin gamma-3 chain	0.0061	0.0481	0.0461
Brugia malayi	Calcium binding EGF domain containing protein	0.0061	0.0481	0.0481
Trichomonas vaginalis	chromobox protein, putative	0.0018	0.0093	0.0258
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0055	0.0428	0.0428
Trichomonas vaginalis	pten, drome, putative	0.0055	0.0428	0.1543
Loa Loa (eye worm)	animal heme peroxidase	0.0189	0.1637	0.1618
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Onchocerca volvulus		0.0061	0.0481	0.1674
Brugia malayi	EGF-like domain containing protein	0.0061	0.0481	0.0481
Plasmodium falciparum	importin beta, putative	0.0022	0.0128	0.5824
Schistosoma mansoni	protein tyrosine phosphatase	0.0055	0.0428	0.0407
Mycobacterium tuberculosis	Probable reductase	0.0069	0.0557	0.4966
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0011	0.0025	0.0003
Schistosoma mansoni	agrin	0.0019	0.0105	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0128	0.0107
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0011	0.0025	0.0084
Schistosoma mansoni	organic anion transporter	0.0028	0.0186	0.0165
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0055	0.0428	0.0407
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Echinococcus granulosus	Solute carrier organic anion transporter family	0.0028	0.0186	0.0165
Brugia malayi	hypothetical protein	0.0055	0.0428	0.0428
Echinococcus granulosus	thioredoxin glutathione reductase	0.003	0.0205	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Brugia malayi	hypothetical protein	0.0189	0.1637	0.1637
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Echinococcus granulosus	protein jagged 1	0.0061	0.0481	0.0461
Echinococcus granulosus	snurportin 1	0.0234	0.2049	0.2031
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0027
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0011	0.0025	0.0003
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Onchocerca volvulus		0.0055	0.0428	0.1467
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0043	0.0318	0.0318
Trichomonas vaginalis	chromobox protein, putative	0.0018	0.0093	0.0258
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Plasmodium vivax	thioredoxin reductase, putative	0.003	0.0205	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0105	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0081	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0186	0.0165
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0011	0.0025	0.0025
Schistosoma mansoni	protein kinase C mu	0.0043	0.0318	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Onchocerca volvulus	Neurogenic locus notch homolog	0.0061	0.0481	0.1674
Schistosoma mansoni	hypothetical protein	0.0061	0.0481	0.0461
Toxoplasma gondii	protease inhibitor PI2	0.0019	0.0105	0.1806
Onchocerca volvulus		0.0055	0.0428	0.1467
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0105	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Onchocerca volvulus		0.0055	0.0428	0.1467
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0037	0.0045
Onchocerca volvulus		0.0043	0.0316	0.1036
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0061	0.0481	0.0461
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0011	0.0025	0.0084
Plasmodium falciparum	glutathione reductase	0.003	0.0205	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0055	0.0428	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1637	0.1618
Onchocerca volvulus		0.0055	0.0428	0.1467
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0299	0.2635	1
Onchocerca volvulus		0.0055	0.0428	0.1467
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0055	0.0428	0.0407
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0055	0.0428	0.0407
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.0028	0.0186	0.0165
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0019	0.0105	0.1806
Echinococcus granulosus	peroxidasin	0.0189	0.1637	0.1618
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0055	0.0428	0.0407
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0061	0.0481	0.0481
Brugia malayi	hypothetical protein	0.0055	0.0428	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1637	0.1618
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0017	0.0081	0.0126
Echinococcus multilocularis	peroxidasin	0.0189	0.1637	0.1618
Echinococcus multilocularis	importin subunit beta 1	0.0022	0.0128	0.0107
Schistosoma mansoni	hypothetical protein	0.0061	0.0481	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Trypanosoma brucei	trypanothione reductase	0.003	0.0205	0.4507
Onchocerca volvulus		0.0019	0.0105	0.0218
Brugia malayi	Animal haem peroxidase family protein	0.0189	0.1637	0.1637
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0055	0.0428	0.0407
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0011	0.0025	0.0084
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0055	0.0428	0.0407
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0011	0.0025	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Leishmania major	tyrosine specific protein phosphatase, putative	0.0055	0.0428	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0055	0.0428	0.0407
Brugia malayi	EGF-like domain containing protein	0.0061	0.0481	0.0481
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.0028	0.0186	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0186	0.0165
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Onchocerca volvulus		0.0028	0.0186	0.0532
Brugia malayi	hypothetical protein	0.0055	0.0428	0.0428
Onchocerca volvulus		0.0044	0.0328	0.108
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.1113	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0055	0.0428	0.0407
Leishmania major	importin beta-1 subunit, putative	0.0018	0.0091	0.1701
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0081	0.0214
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0055	0.0428	0.0407
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0055	0.0428	0.0407
Onchocerca volvulus		0.0028	0.0186	0.0532
Brugia malayi	Animal haem peroxidase family protein	0.0189	0.1637	0.1637
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0055	0.0428	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Onchocerca volvulus		0.0055	0.0428	0.1467
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1637	0.1618
Echinococcus granulosus	protein jagged 2	0.0061	0.0481	0.0461
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Schistosoma mansoni	slit	0.0061	0.0481	0.0461
Brugia malayi	Thioredoxin reductase	0.003	0.0205	0.0205
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0055	0.0428	0.0407
Echinococcus granulosus	notch	0.0061	0.0481	0.0461
Toxoplasma gondii	transporter, major facilitator family protein	0.0028	0.0186	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0186	0.0165
Entamoeba histolytica	glycogen phosphorylase, putative	0.0129	0.11	0.3965
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0055	0.0428	0.0407
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0043	0.0318	0.0296
Echinococcus multilocularis	expressed protein	0.0019	0.0105	0.0083
Onchocerca volvulus	4.1 G protein, putative homolog	0.0055	0.0428	0.1467
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0011	0.0025	0.0084
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.0028	0.0186	0.0165
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0055	0.0428	0.0407
Echinococcus multilocularis		0.0055	0.0428	0.0407
Onchocerca volvulus		0.0055	0.0428	0.1467
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0055	0.0428	0.0407
Onchocerca volvulus		0.0055	0.0428	0.1467
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0011	0.0025	0.0084
Trypanosoma brucei	importin beta-1 subunit, putative	0.0022	0.0128	0.2625
Echinococcus multilocularis	protein jagged 1	0.0061	0.0481	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0186	0.0165
Brugia malayi	Heterochromatin protein 1	0.003	0.02	0.02
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0011	0.0025	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Onchocerca volvulus		0.0061	0.0481	0.1674
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Brugia malayi	Cadherin domain containing protein	0.0061	0.0481	0.0481
Brugia malayi	hypothetical protein	0.0055	0.0428	0.0428
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0019	0.0105	0.0105
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0055	0.0428	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0077	0.0627	0.5615
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0055	0.0428	1
Echinococcus multilocularis	glycogen phosphorylase	0.0299	0.2635	0.2619
Echinococcus granulosus	slit 2 protein	0.0061	0.0481	0.0461
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0055	0.0428	0.0407
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0018	0.0093	0.0171
Onchocerca volvulus	Putative cubilin	0.0061	0.0481	0.1674
Brugia malayi	SPARC precursor	0.0019	0.0105	0.0105
Echinococcus multilocularis	thioredoxin glutathione reductase	0.003	0.0205	0.0183
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0011	0.0025	0.0032
Toxoplasma gondii	HEAT repeat-containing protein	0.0022	0.0128	0.232
Brugia malayi	prostaglandin transporter	0.0028	0.0186	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0428	0.0407
Plasmodium vivax	importin-beta 2, putative	0.0022	0.0128	0.5824
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0055	0.0428	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0055	0.0428	0.0407
Brugia malayi	Cadherin domain containing protein	0.0061	0.0481	0.0481
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0428	0.0428
Loa Loa (eye worm)	thioredoxin reductase	0.003	0.0205	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0186	0.0165
Brugia malayi	hypothetical protein	0.0055	0.0428	0.0428
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0299	0.2635	0.2619
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0055	0.0428	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0316	0.0295
Onchocerca volvulus		0.0189	0.1637	0.614
Echinococcus granulosus	neurogenic locus notch protein	0.0061	0.0481	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1637	0.1618
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0055	0.0428	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Schistosoma mansoni	glycogen phosphorylase	0.0299	0.2635	0.2619
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0055	0.0428	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0481	0.0461
Entamoeba histolytica	glycogen phosphorylase, putative	0.0299	0.2635	1
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0038	0.0275	0.0254
Brugia malayi	sodium-independent organic anion transporter family protein	0.0028	0.0186	0.0186
Schistosoma mansoni	follistatin	0.0019	0.0105	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1637	0.1618
Onchocerca volvulus		0.0055	0.0428	0.1467
Brugia malayi	sodium-independent organic anion transporter family protein	0.0028	0.0186	0.0186
Brugia malayi	C1-like domain containing protein	0.0043	0.0318	0.0318
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0055	0.0428	1
Brugia malayi	MH2 domain containing protein	0.0051	0.0392	0.0392
Onchocerca volvulus	Putative organic anion transporter	0.0028	0.0186	0.0532
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0069	0.0557	0.4966
Brugia malayi	EGF-like domain containing protein	0.0061	0.0481	0.0481
Plasmodium falciparum	thioredoxin reductase	0.003	0.0205	1
Trypanosoma cruzi	trypanothione reductase, putative	0.003	0.0205	0.4507
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0061	0.0481	0.1674
Toxoplasma gondii	thioredoxin reductase	0.003	0.0205	0.3983

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1740901

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1558508