Detailed information for compound 1563111

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 426.532 | Formula: C22H26N4O3S
  • H donors: 2 H acceptors: 4 LogP: 4.91 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(NC(=O)c1ncn(c1NS(=O)(=O)c1ccc(cc1)C)c1ccccc1)CC
  • InChi: 1S/C22H26N4O3S/c1-4-17(5-2)24-22(27)20-21(26(15-23-20)18-9-7-6-8-10-18)25-30(28,29)19-13-11-16(3)12-14-19/h6-15,17,25H,4-5H2,1-3H3,(H,24,27)
  • InChiKey: PGVDOQBTJPQKAP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens formyl peptide receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0169 0.1891 0.2297
Brugia malayi tailless protein 0.0015 0.0013 0.0036
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0872 0.0872
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.2688 0.9703
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0037 0.0098
Schistosoma mansoni smad1 5 8 and 0.0016 0.0022 0.0027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0037 0.0098
Echinococcus granulosus calcium activated potassium channel 0.0045 0.0382 0.0464
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0019 0.0058
Toxoplasma gondii microneme protein MIC4 0.0018 0.0051 0.0095
Schistosoma mansoni single-minded 0.0059 0.0553 0.0671
Echinococcus granulosus sentrin specific protease 1 0.004 0.0313 0.038
Loa Loa (eye worm) hypothetical protein 0.0034 0.0242 0.0874
Echinococcus multilocularis neuropeptide receptor 0.0165 0.1836 0.1836
Onchocerca volvulus 0.0024 0.0124 0.081
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0221 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0221 0.0789
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0049 0.0165
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0124 0.0439
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0313 0.088
Schistosoma mansoni smad1 5 8 and 0.0016 0.0022 0.0027
Leishmania major delta-5 fatty acid desaturase 0.0106 0.1116 0.3057
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0019 0.0011
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0313 0.088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0929 0.1128
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.004 0.0313 0.038
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0221 0.0269
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0013 0.0016
Echinococcus granulosus sentrin specific protease 8 0.0095 0.0984 0.1195
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0095 0.0984 1
Echinococcus granulosus Niemann Pick C1 protein 0.0285 0.3306 0.4016
Echinococcus granulosus neuropeptide receptor A26 0.0471 0.5572 0.6768
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0221 0.0269
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0221 0.1516
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0221 0.0789
Toxoplasma gondii microneme protein, putative 0.0018 0.0051 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0313 0.3067
Onchocerca volvulus 0.0018 0.0051 0.0274
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0095 0.0984 0.1195
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.2688 0.9703
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.004 0.0313 0.0825
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0013 0.0016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0128
Loa Loa (eye worm) hypothetical protein 0.0113 0.1205 0.4351
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0221 0.0789
Brugia malayi nuclear hormone receptor 0.0015 0.0013 0.0036
Schistosoma mansoni coup transcription factor 0.0032 0.0221 0.0269
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0242 0.0864
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.036 0.0956
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.1131 0.1131
Schistosoma mansoni neuropeptide receptor 0.0165 0.1836 0.223
Brugia malayi hypothetical protein 0.0015 0.0016 0.0045
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.1131 0.1374
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0221 0.1516
Schistosoma mansoni patched 1 0.0086 0.0872 0.1059
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.004 0.0313 0.3067
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0022 0.0027
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0221 0.0799
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0013 0.0047
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.004 0.0313 0.3067
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0221 0.0269
Brugia malayi hypothetical protein 0.0017 0.0035 0.0117
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0313 0.1119
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0013 0.0013
Brugia malayi Niemann-Pick C1 protein precursor 0.02 0.2261 0.8161
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0124 0.0424
Echinococcus multilocularis transfer RNA-Lys 0.0044 0.0364 0.0364
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0049 0.1016
Echinococcus multilocularis G protein coupled receptor 139 0.0165 0.1836 0.1836
Echinococcus multilocularis neuropeptide s receptor 0.0471 0.5572 0.5572
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0095 0.0984 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0221 0.0789
Brugia malayi PAN domain containing protein 0.0018 0.0051 0.0172
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0013 0.0016
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0156 0.0561
Echinococcus granulosus lamin 0.0027 0.0156 0.0189
Echinococcus multilocularis lamin 0.0027 0.0156 0.0156
Brugia malayi PAN domain containing protein 0.0018 0.0051 0.0172
Brugia malayi nuclear receptor NHR-88 0.0032 0.0221 0.0789
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0221 0.0789
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0124 0.0582
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0929 0.1128
Brugia malayi nuclear hormone receptor 0.0032 0.0221 0.0789
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0013 0.0036
Onchocerca volvulus 0.0045 0.037 0.2598
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0013 0.0016
Toxoplasma gondii PAN domain-containing protein 0.0018 0.0051 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0221 0.0799
Schistosoma mansoni calcium-activated potassium channel 0.0042 0.0343 0.0417
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0221 0.0269
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0019 0.0023
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0221 0.0269
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0221 0.0799
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.036 0.0956
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0128
Toxoplasma gondii PAN domain-containing protein 0.0018 0.0051 0.0095
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0221 0.0221
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0221 0.0269
Brugia malayi CHE-14 protein 0.0086 0.0872 0.3139
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0124 0.0439
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0929 0.1128
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.02 0.2261 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.0706
Echinococcus granulosus potassium large conductance calcium activated 0.0045 0.0382 0.0464
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0003 0.0011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0035 0.0043
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.162 0.4457
Brugia malayi Smad1 0.0016 0.0022 0.0068
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0221 0.0799
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0019 0.0011
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.162 0.4451
Schistosoma mansoni microtubule-associated protein tau 0.0689 0.8233 1
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0313 0.1119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0221 0.0799
Schistosoma mansoni fatty acid desaturase 0.0106 0.112 0.1361
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0013 0.0036
Echinococcus multilocularis potassium large conductance calcium activated 0.0045 0.0382 0.0382
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0019 0.0019
Brugia malayi PAS domain containing protein 0.0059 0.0553 0.1986
Echinococcus granulosus smad 0.0016 0.0022 0.0027
Schistosoma mansoni hypothetical protein 0.0034 0.0242 0.0294
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0221 0.0789
Loa Loa (eye worm) hypothetical protein 0.0113 0.1199 0.4329
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0013 0.0013
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0013 0.0036
Echinococcus granulosus GPCR family 2 0.0016 0.0019 0.0023
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0013 0.0013
Brugia malayi PAN domain containing protein 0.0018 0.0051 0.0172
Schistosoma mansoni smad1 5 8 and 0.0016 0.0022 0.0027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0037 0.0098
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0095 0.0984 0.3544
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0221 0.0221
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0016 0.0022 0.0027
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0013 0.0016
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.0023
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.3616 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0019 0.0019
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0178 0.2004 0.8794
Mycobacterium ulcerans hypothetical protein 0.0164 0.1823 1
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0016 0.0022 0.0079
Loa Loa (eye worm) PAN domain-containing protein 0.0018 0.0051 0.0183
Loa Loa (eye worm) hypothetical protein 0.0018 0.0051 0.0183
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0112 0.1189 0.1189
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0221 0.0799
Toxoplasma gondii hypothetical protein 0.005 0.0438 0.1275
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0095 0.0984 1
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.004 0.0313 0.0893
Echinococcus multilocularis protein patched 0.0086 0.0872 0.0872
Loa Loa (eye worm) Ulp1 protease 0.0095 0.0984 0.3551
Onchocerca volvulus Huntingtin homolog 0.0122 0.1319 0.9503
Onchocerca volvulus 0.0027 0.0156 0.1036
Loa Loa (eye worm) hypothetical protein 0.0024 0.0124 0.0449
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0019 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0178
Onchocerca volvulus 0.0027 0.0156 0.1036
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0221 0.0221
Echinococcus multilocularis microtubule associated protein 2 0.0689 0.8233 0.8233
Echinococcus multilocularis sentrin specific protease 7 0.0178 0.2004 0.2004
Toxoplasma gondii microneme protein MIC17A 0.0018 0.0051 0.0095
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0221 0.0789
Onchocerca volvulus 0.0018 0.0051 0.0274
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0022 0.0027
Brugia malayi intermediate filament protein 0.0027 0.0156 0.0551
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0124 0.0582
Schistosoma mansoni hypothetical protein 0.0169 0.1891 0.2297
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0022 0.0022
Echinococcus granulosus expressed conserved protein 0.0139 0.1518 0.1844
Loa Loa (eye worm) hypothetical protein 0.0032 0.0221 0.0799
Echinococcus granulosus Smad4 0.0016 0.0022 0.0027
Mycobacterium ulcerans hypothetical protein 0.0024 0.0124 0.0424
Trypanosoma cruzi hypothetical protein 0.0095 0.0984 0.2689
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0221 0.0789
Toxoplasma gondii PAN/Apple domain-containing protein 0.0018 0.0051 0.0095
Onchocerca volvulus 0.0018 0.0051 0.0274
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0221 0.0221
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0013 0.0013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0013 0.0013
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0095 0.0987 0.3563
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0049 0.1016
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0035 0.0117
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0124 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0051 0.0183
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.1128
Loa Loa (eye worm) hypothetical protein 0.0122 0.1319 0.4763
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0047
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0929 0.3345
Echinococcus multilocularis calcium activated potassium channel 0.0045 0.0382 0.0382
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0706 0.0706
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0221 0.1516
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.162 0.4457
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0929 0.0929
Brugia malayi PAN domain containing protein 0.0018 0.0051 0.0172
Echinococcus multilocularis Niemann Pick C1 protein 0.0285 0.3306 0.3306
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0013 0.0016
Echinococcus granulosus single minded 2 0.0044 0.0364 0.0442
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0128
Schistosoma mansoni intermediate filament proteins 0.0027 0.0156 0.0189
Loa Loa (eye worm) hypothetical protein 0.0122 0.1319 0.4763
Loa Loa (eye worm) hypothetical protein 0.0128 0.1388 0.5009
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0013 0.0016
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0221 0.0221
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0872 0.1059
Brugia malayi follicle stimulating hormone receptor 0.0241 0.277 1
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0872 0.1059
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.004 0.0313 0.3067
Toxoplasma gondii microneme protein MIC17C 0.0018 0.0051 0.0095
Loa Loa (eye worm) hypothetical protein 0.0032 0.0221 0.0799
Plasmodium vivax sentrin-specific protease 1, putative 0.004 0.0313 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0124 0.0424
Loa Loa (eye worm) hypothetical protein 0.0032 0.0221 0.0799
Toxoplasma gondii PAN domain-containing protein 0.0285 0.3303 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0019 0.0069
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0124 0.0424
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0095 0.0984 0.4021
Loa Loa (eye worm) hypothetical protein 0.0032 0.0221 0.0799
Brugia malayi MH2 domain containing protein 0.0016 0.0022 0.0068
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0022 0.0079
Toxoplasma gondii subtilisin SUB12 0.0018 0.0051 0.0095
Echinococcus multilocularis neuropeptide receptor A26 0.0471 0.5572 0.5572
Onchocerca volvulus 0.0018 0.0051 0.0274
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0128
Echinococcus multilocularis expressed conserved protein 0.0139 0.1518 0.1518
Echinococcus granulosus microtubule associated protein 2 0.0689 0.8233 1
Entamoeba histolytica hypothetical protein 0.0107 0.1131 0.4712
Loa Loa (eye worm) hypothetical protein 0.0032 0.0221 0.0799
Brugia malayi hypothetical protein 0.0015 0.0013 0.0036
Brugia malayi ecdysteroid receptor 0.0032 0.0221 0.0789
Brugia malayi isocitrate dehydrogenase 0.0016 0.0019 0.006
Echinococcus multilocularis lamin dm0 0.0027 0.0156 0.0156
Schistosoma mansoni hypothetical protein 0.0107 0.1131 0.1374
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0124 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0221 0.0269
Brugia malayi MH1 domain containing protein 0.0016 0.0022 0.0068
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0013 0.0016
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0042 0.0343 0.1238
Trichomonas vaginalis Sentrin-specific protease, putative 0.0095 0.0984 1
Brugia malayi nuclear receptor RXR 0.0017 0.0035 0.0117
Plasmodium vivax sentrin-specific protease 2, putative 0.004 0.0313 1
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0221 0.0789
Schistosoma mansoni zinc finger protein 0.0015 0.0013 0.0016
Brugia malayi hypothetical protein 0.0017 0.0035 0.0117
Loa Loa (eye worm) hypothetical protein 0.0018 0.0051 0.0183
Entamoeba histolytica hypothetical protein 0.0107 0.1131 0.4712
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0221 0.0221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0221 0.0799
Schistosoma mansoni lamin 0.0027 0.0156 0.0189
Loa Loa (eye worm) hypothetical protein 0.0027 0.0156 0.0561
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0221 0.0789
Echinococcus granulosus calcium activated potassium channel variant 0.0042 0.0343 0.0417
Loa Loa (eye worm) DR-78 0.0015 0.0013 0.0047
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0019 0.0019
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0013 0.0016
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0047
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.1823 1
Brugia malayi PAN domain containing protein 0.0018 0.0051 0.0172
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.003 0.0196 0.0696
Brugia malayi bHLH-PAS transcription factor 0.0044 0.0364 0.1304
Echinococcus granulosus expressed conserved protein 0.0188 0.2114 0.2567
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0129 0.1398 0.1698
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.004 0.0313 0.0825
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0156 0.0561
Echinococcus granulosus aryl hydrocarbon receptor 0.0128 0.1394 0.1693
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0035 0.0043
Entamoeba histolytica hypothetical protein 0.0107 0.1131 0.4712
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0047
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.036 0.0946
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.004 0.0313 1
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0047
Entamoeba histolytica hypothetical protein 0.0107 0.1131 0.4712
Loa Loa (eye worm) hypothetical protein 0.02 0.2261 0.8163
Echinococcus multilocularis musashi 0.0027 0.0156 0.0156
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0221 0.0269
Echinococcus granulosus Niemann Pick C1 protein 0.02 0.2261 0.2747
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0124 0.0302
Loa Loa (eye worm) hypothetical protein 0.0024 0.0124 0.0449
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0221 0.0789
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0221 0.0269
Toxoplasma gondii PAN domain-containing protein 0.0285 0.3303 1
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.004 0.0313 1
Onchocerca volvulus 0.0106 0.112 0.8053
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0013 0.0036
Echinococcus granulosus geminin 0.0169 0.1891 0.2297
Brugia malayi PAN domain containing protein 0.0018 0.0051 0.0172
Loa Loa (eye worm) hypothetical protein 0.0018 0.0051 0.0183
Onchocerca volvulus 0.0018 0.0051 0.0274
Giardia lamblia Sentrin specific protease, putative 0.004 0.0313 0.5
Onchocerca volvulus 0.004 0.0313 0.2179
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0178
Toxoplasma gondii hypothetical protein 0.0018 0.0051 0.0095
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0221 0.0269
Brugia malayi PAN domain containing protein 0.0018 0.0051 0.0172
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0016 0.0022 0.0022
Loa Loa (eye worm) PAN domain-containing protein 0.0018 0.0051 0.0183
Brugia malayi hypothetical protein 0.0107 0.1131 0.4078
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0013 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0221 0.0789
Loa Loa (eye worm) hypothetical protein 0.0024 0.0124 0.0449
Brugia malayi MH2 domain containing protein 0.0235 0.2688 0.9702
Loa Loa (eye worm) hypothetical protein 0.0086 0.0872 0.3147
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0872 0.8843
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0221 0.0221
Brugia malayi hypothetical protein 0.0015 0.0013 0.0036
Echinococcus multilocularis Niemann Pick C1 protein 0.02 0.2261 0.2261
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.036 0.0956
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.1128
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0221 0.0269
Echinococcus multilocularis smad 0.0016 0.0022 0.0022
Brugia malayi hypothetical protein 0.0122 0.1319 0.4757
Loa Loa (eye worm) PAN domain-containing protein 0.0018 0.0051 0.0183
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0124 0.0439
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0929 0.1128
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0241 0.277 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0047
Onchocerca volvulus Huntingtin homolog 0.0122 0.1319 0.9503
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0128
Loa Loa (eye worm) hypothetical protein 0.0018 0.0051 0.0183
Schistosoma mansoni hypothetical protein 0.0083 0.0834 0.1013
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0022 0.0079
Loa Loa (eye worm) hypothetical protein 0.0026 0.015 0.054
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.004 0.0313 0.3067
Brugia malayi conserved hypotetical protein 0.0015 0.0013 0.0036
Echinococcus granulosus sentrin specific protease 7 0.0178 0.2004 0.2434
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0019 0.006
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0124 0.0424
Echinococcus granulosus neuropeptide s receptor 0.0471 0.5572 0.6768
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0178
Loa Loa (eye worm) hypothetical protein 0.0032 0.0221 0.0799
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0035 0.0043
Schistosoma mansoni nuclear receptor 0.0015 0.0013 0.0016
Brugia malayi nuclear receptor RXR 0.0015 0.0013 0.0036
Loa Loa (eye worm) hypothetical protein 0.0032 0.0221 0.0799
Echinococcus multilocularis tumor protein p63 0.0678 0.8097 0.8097
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0047
Echinococcus multilocularis GPCR, family 2 0.0016 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.005 0.0434 0.1568
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0013 0.0036
Loa Loa (eye worm) PAN domain-containing protein 0.0018 0.0051 0.0183
Toxoplasma gondii hypothetical protein 0.0018 0.0051 0.0095
Schistosoma mansoni calcium-activated potassium channel 0.0045 0.0382 0.0464
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.3616 1
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0313 0.088
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0313 0.088
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0124 0.0424
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0013 0.0047
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.004 0.0313 0.3067
Echinococcus multilocularis Smad4 0.0016 0.0022 0.0022
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0035 0.0035
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0022 0.0027
Echinococcus multilocularis expressed conserved protein 0.0188 0.2114 0.2114
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0221 0.0789
Echinococcus multilocularis sentrin specific protease 8 0.0095 0.0984 0.0984
Onchocerca volvulus 0.0018 0.0051 0.0274
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0019 0.0019
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0434 0.1559
Loa Loa (eye worm) Smad1 0.0016 0.0022 0.0079
Trypanosoma brucei SUMO1/Ulp2, putative 0.004 0.0313 0.0815
Brugia malayi PAN domain containing protein 0.0018 0.0051 0.0172
Echinococcus multilocularis aryl hydrocarbon receptor 0.0128 0.1394 0.1394
Brugia malayi MH1 domain containing protein 0.0016 0.0022 0.0068
Echinococcus multilocularis calcium activated potassium channel variant 0.0042 0.0343 0.0343
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0929 0.0929
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0113 0.1199 0.4323
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.004 0.0313 0.3067
Schistosoma mansoni nuclear receptor 0.0015 0.0013 0.0016
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0178
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.0023
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0019 0.0024
Toxoplasma gondii PAN domain-containing protein 0.0018 0.0051 0.0095
Mycobacterium ulcerans putative regulatory protein 0.0044 0.0364 0.1775
Leishmania major mitochondrial DNA polymerase beta 0.0311 0.3616 1
Brugia malayi PAN domain containing protein 0.0018 0.0051 0.0172
Onchocerca volvulus 0.0018 0.0051 0.0274
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0221 0.0789
Onchocerca volvulus 0.0032 0.0221 0.1516
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0221 0.0269
Brugia malayi ecdysone receptor 0.0015 0.0013 0.0036
Echinococcus granulosus tumor protein p63 0.0678 0.8097 0.9835
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0047
Loa Loa (eye worm) FAT-3 protein 0.0106 0.1116 0.4029
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0049 0.1134
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0313 0.1119
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0018 0.0051 0.0095
Schistosoma mansoni hypothetical protein 0.0083 0.0834 0.1013
Schistosoma mansoni lamin 0.0027 0.0156 0.0189
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0221 0.0269
Schistosoma mansoni Smad4 0.0016 0.0022 0.0027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0037 0.0098
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0019 0.0024
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0047
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0178 0.2004 0.2434
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0221 0.0799
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0019 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0013 0.0016
Loa Loa (eye worm) Ulp1 protease 0.004 0.0313 0.1128
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.004 0.0313 0.038
Onchocerca volvulus 0.0018 0.0051 0.0274
Brugia malayi MH2 domain containing protein 0.0016 0.0022 0.0068
Plasmodium falciparum sentrin-specific protease 1 0.004 0.0313 1
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0221 0.0269
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0156 0.0551
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0221 0.0789
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0929 0.3352
Brugia malayi nuclear receptor NHR-88 0.0015 0.0013 0.0036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0221 0.0221
Trypanosoma cruzi SUMO1/Ulp2, putative 0.004 0.0313 0.0825
Loa Loa (eye worm) hypothetical protein 0.0105 0.1107 0.3995
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0019 0.0058
Toxoplasma gondii microneme protein MIC17B 0.0018 0.0051 0.0095
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0013 0.0016
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0221 0.0269
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0056
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0019 0.0019
Loa Loa (eye worm) MaxiK calcium-activated potassium channel 0.003 0.0196 0.0706
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0872 0.3147
Onchocerca volvulus 0.0018 0.0051 0.0274
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0019 0.007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0051 0.0183
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0434 0.1559
Brugia malayi steroid hormone receptor 0.0032 0.0221 0.0789
Loa Loa (eye worm) hypothetical protein 0.0032 0.0221 0.0799
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0035 0.0128
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0124 0.0424
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.1128
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.004 0.0313 0.0893
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.004 0.0313 0.0893
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0124 0.0424
Echinococcus multilocularis protein dispatched 1 0.0098 0.1019 0.1019
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.004 0.0313 0.3067
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0221 0.0269
Echinococcus multilocularis sentrin specific protease 1 0.004 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0047
Onchocerca volvulus 0.0018 0.0051 0.0274
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0221 0.0269
Schistosoma mansoni hypothetical protein 0.0083 0.0834 0.1013
Brugia malayi nuclear receptor NHR-67 0.0015 0.0013 0.0036
Schistosoma mansoni retinoic acid receptor RXR 0.0129 0.1398 0.1698
Brugia malayi PAN domain containing protein 0.0018 0.0051 0.0172
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0706 0.0857
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0019 0.0023
Schistosoma mansoni smad 0.0016 0.0022 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0051 0.0183
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0035 0.0117
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0099 0.1038 0.3745
Echinococcus granulosus neuropeptide receptor 0.0165 0.1836 0.223
Onchocerca volvulus 0.0099 0.1038 0.7452
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0047
Onchocerca volvulus 0.0018 0.0051 0.0274
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0221 0.0269
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0124 0.0302
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0124 0.0302
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0434 0.1568
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0203 0.2299 0.2792
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.1038 0.126
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0929 0.1128
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.1131 0.1374
Echinococcus multilocularis geminin 0.0169 0.1891 0.1891
Schistosoma mansoni hypothetical protein 0.0083 0.0834 0.1013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0221 0.0789
Loa Loa (eye worm) PAN domain-containing protein 0.0018 0.0051 0.0183
Brugia malayi Delta5 fatty acid desaturase 0.0106 0.1116 0.4022
Toxoplasma gondii PAN domain-containing protein 0.0018 0.0051 0.0095
Loa Loa (eye worm) hypothetical protein 0.0106 0.1116 0.4029
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0013 0.0047
Echinococcus granulosus intermediate filament protein 0.0027 0.0156 0.0189
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0022 0.0022
Echinococcus granulosus lamin dm0 0.0027 0.0156 0.0189
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0476 0.128
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0178
Schistosoma mansoni aryl hydrocarbon receptor 0.0173 0.1931 0.2345
Onchocerca volvulus 0.0128 0.1388 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0311 0.3616 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 5.8 Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay ChEMBL. 21955939

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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