Detailed information for compound 1563391

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 267.349 | Formula: C15H13N3S
  • H donors: 1 H acceptors: 2 LogP: 3.35 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Sc1ncc2c(n1)c1[nH]c3c(c1CCC2)cccc3
  • InChi: 1S/C15H13N3S/c19-15-16-8-9-4-3-6-11-10-5-1-2-7-12(10)17-14(11)13(9)18-15/h1-2,5,7-8,17H,3-4,6H2,(H,16,18,19)
  • InChiKey: HCUZYCOIDNBQKE-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0009 0.0095 0.0367
Brugia malayi hypothetical protein 0.0009 0.0101 0.039
Schistosoma mansoni adenoreceptor 0.0009 0.0101 0.0101
Echinococcus multilocularis serotonin receptor 0.0141 0.419 0.419
Brugia malayi RNA, U transporter 1 0.0087 0.2531 0.9748
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0009 0.0095 0.0539
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0101 0.0101
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0101 0.0101
Echinococcus multilocularis neuropeptide s receptor 0.0009 0.0101 0.0101
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0009 0.0101 0.0101
Echinococcus granulosus serotonin receptor 0.0009 0.0101 0.0101
Brugia malayi Serotonin receptor 0.0009 0.0101 0.039
Toxoplasma gondii cytochrome p450 superfamily protein 0.0008 0.0057 0.0567
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.101 0.101
Leishmania major farnesyltransferase beta subunit 0.0009 0.0095 0.0943
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0101 0.0101
Onchocerca volvulus 0.0009 0.0101 0.0186
Loa Loa (eye worm) hypothetical protein 0.0008 0.0065 0.0065
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.101 0.5713
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0101 0.0101
Echinococcus granulosus cytochrome P450 2K1 0.0008 0.0057 0.0057
Brugia malayi larval opioid receptor 0.0009 0.0101 0.039
Loa Loa (eye worm) hypothetical protein 0.0029 0.0725 0.0725
Loa Loa (eye worm) beta-lactamase 0.0038 0.101 0.101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0101 0.0101
Echinococcus granulosus g protein coupled receptor 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Echinococcus granulosus histone lysine methyltransferase setb 0.0008 0.0065 0.0065
Onchocerca volvulus 0.0009 0.0101 0.0186
Echinococcus multilocularis survival motor neuron protein 1 0.0063 0.1765 0.1765
Echinococcus multilocularis carbonic anhydrase 0.0023 0.0539 0.0539
Mycobacterium tuberculosis Conserved protein 0.0038 0.101 0.1293
Onchocerca volvulus 0.0009 0.0101 0.0186
Trypanosoma cruzi protein farnesyltransferase, putative 0.0009 0.0095 0.0398
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0009 0.0101 0.0101
Schistosoma mansoni ran 0.0023 0.0521 0.0521
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0009 0.0101 0.0101
Schistosoma mansoni hypothetical protein 0.0009 0.0101 0.0101
Onchocerca volvulus 0.0009 0.0101 0.0186
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0101 0.0101
Onchocerca volvulus Neuropeptide F receptor homolog 0.0009 0.0101 0.0186
Loa Loa (eye worm) hypothetical protein 0.0038 0.101 0.101
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.101 0.5713
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0101 0.0101
Mycobacterium leprae conserved hypothetical protein 0.0038 0.101 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.7427 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.2521 0.2521
Mycobacterium leprae Probable threonine dehydratase IlvA 0.0026 0.0628 0.5984
Toxoplasma gondii ABC1 family protein 0.0038 0.101 1
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0101 0.0101
Onchocerca volvulus 0.0013 0.0216 0.0781
Brugia malayi GnHR receptor homolog 0.0009 0.0101 0.039
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.101 0.5713
Echinococcus granulosus neuropeptide receptor A26 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0025 0.0582 0.0582
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0101 0.0101
Loa Loa (eye worm) TYRA-2 protein 0.0009 0.0101 0.0101
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0006 0.002 0.0203
Loa Loa (eye worm) hypothetical protein 0.0023 0.0539 0.0539
Schistosoma mansoni jun-related protein 0.0073 0.2077 0.2077
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0023 0.0539 0.0539
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Brugia malayi neuropeptide F receptor 0.0009 0.0101 0.039
Schistosoma mansoni importin beta-1 0.0031 0.0773 0.0773
Brugia malayi Importin beta-1 subunit 0.0031 0.0773 0.2978
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0101 0.0101
Trypanosoma brucei lanosterol synthase 0.001 0.0122 0.1208
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0101 0.0101
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0009 0.0101 0.0101
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.101 1
Entamoeba histolytica threonine dehydratase, putative 0.0026 0.0628 1
Echinococcus granulosus carbonic anhydrase II 0.0023 0.0539 0.0539
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0257 0.0257
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0009 0.0101 0.0101
Brugia malayi hypothetical protein 0.0009 0.0101 0.039
Echinococcus multilocularis serotonin receptor 0.0141 0.419 0.419
Schistosoma mansoni amine GPCR 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0009 0.0101 0.0101
Leishmania major cytochrome p450-like protein 0.0008 0.0057 0.0567
Echinococcus granulosus neuropeptide receptor 0.0009 0.0101 0.0101
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0019 0.0423 0.0423
Trichomonas vaginalis threonine dehydratase/deaminase, putative 0.0026 0.0628 0.3548
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0009 0.0101 0.0101
Onchocerca volvulus 0.0009 0.0101 0.0186
Loa Loa (eye worm) hypothetical protein 0.0031 0.0773 0.0773
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Brugia malayi hypothetical protein 0.0009 0.0101 0.039
Echinococcus multilocularis dro:myosuppressin receptor 0.0009 0.0101 0.0101
Brugia malayi Pre-SET motif family protein 0.0008 0.0065 0.0251
Trypanosoma cruzi lanosterol synthase, putative 0.001 0.0122 0.0679
Brugia malayi hypothetical protein 0.0009 0.0101 0.039
Schistosoma mansoni amine GPCR 0.0009 0.0101 0.0101
Brugia malayi Cytochrome P450 family protein 0.0008 0.0057 0.0221
Echinococcus multilocularis G-protein coupled receptor, putative 0.0009 0.0101 0.0101
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0057 0.0057
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0101 0.0101
Brugia malayi Cytochrome P450 family protein 0.0008 0.0057 0.0221
Mycobacterium tuberculosis Conserved protein 0.0038 0.101 0.1293
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0055 0.1532 0.1532
Echinococcus multilocularis lamin 0.0029 0.0725 0.0725
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0101 0.0101
Onchocerca volvulus 0.0009 0.0101 0.0186
Brugia malayi G-protein coupled receptor 0.0009 0.0101 0.039
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0725 0.0725
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0101 0.0101
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0521 0.2008
Entamoeba histolytica Ran family GTPase 0.0023 0.0521 0.8309
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0521 0.0521
Loa Loa (eye worm) hypothetical protein 0.0023 0.0539 0.0539
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0101 0.0101
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0008 0.0065 0.0065
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0019 0.0426 0.0426
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0101 0.0101
Onchocerca volvulus 0.0009 0.0101 0.0186
Trichomonas vaginalis esterase, putative 0.0038 0.101 0.5713
Echinococcus granulosus importin subunit beta 1 0.0031 0.0773 0.0773
Echinococcus multilocularis sex peptide receptor 0.0009 0.0101 0.0101
Brugia malayi ORL1-like opioid receptor 0.0009 0.0101 0.039
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0008 0.0065 0.0646
Brugia malayi putative neuropeptide receptor 0.0009 0.0101 0.039
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0057 0.0057
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0009 0.0095 0.0539
Trichomonas vaginalis threonine dehydratase/deaminase, putative 0.0026 0.0628 0.3548
Schistosoma mansoni amine GPCR 0.0009 0.0101 0.0101
Echinococcus multilocularis musashi 0.0029 0.0725 0.0725
Brugia malayi Tachykinin-like peptides receptor 99D 0.0009 0.0101 0.039
Loa Loa (eye worm) hypothetical protein 0.0029 0.0708 0.0708
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0101 0.0101
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0101 0.0101
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0009 0.0101 0.039
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0008 0.0065 0.0065
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0101 0.0101
Giardia lamblia Threonine dehydratase lateral transfer candidate 0.0026 0.0628 1
Schistosoma mansoni lamin 0.0029 0.0725 0.0725
Echinococcus granulosus peptide allatostatin:somatostatin 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0038 0.101 0.101
Mycobacterium tuberculosis Probable threonine dehydratase IlvA 0.0026 0.0628 0.0774
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.101 0.1293
Onchocerca volvulus 0.0009 0.0101 0.0186
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0101 0.0101
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.001 0.0122 0.0088
Schistosoma mansoni ran 0.0023 0.0521 0.0521
Schistosoma mansoni myosin xvIII 0.0009 0.0101 0.0101
Entamoeba histolytica threonine dehydratase, putative 0.0026 0.0628 1
Brugia malayi Pre-SET motif family protein 0.0055 0.1532 0.5899
Onchocerca volvulus 0.0038 0.101 0.4884
Echinococcus multilocularis lamin dm0 0.0029 0.0725 0.0725
Schistosoma mansoni growth factor receptor-bound protein 0.0019 0.0423 0.0423
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0023 0.0539 0.2076
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Brugia malayi RE15519p 0.0009 0.0101 0.039
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0521 0.5161
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0009 0.0101 0.0101
Schistosoma mansoni growth hormone secretagogue receptor 0.0009 0.0101 0.0101
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0101 0.0101
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0009 0.0101 0.0101
Brugia malayi cytochrome P450 0.0008 0.0057 0.0221
Onchocerca volvulus 0.0009 0.0101 0.0186
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0009 0.0101 0.0186
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0008 0.0056 0.0056
Echinococcus granulosus neuropeptide FF receptor 2 0.0009 0.0101 0.0101
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0008 0.0065 0.0065
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.101 0.1293
Onchocerca volvulus 0.0009 0.0101 0.0186
Schistosoma mansoni carbonic anhydrase-related 0.0023 0.0539 0.0539
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0101 0.0101
Schistosoma mansoni amine GPCR 0.0009 0.0101 0.0101
Loa Loa (eye worm) CYP4Cod1 0.0008 0.0057 0.0057
Schistosoma mansoni neuropeptide receptor 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Trichomonas vaginalis ran, putative 0.0023 0.0521 0.2949
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0023 0.0539 0.0539
Loa Loa (eye worm) hypothetical protein 0.0141 0.419 0.419
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0009 0.0101 0.0101
Echinococcus multilocularis carbonic anhydrase 0.0023 0.0539 0.0539
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0141 0.419 0.419
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0101 0.0101
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.101 0.5713
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.101 0.1293
Echinococcus granulosus dro:myosuppressin receptor 0.0009 0.0101 0.0101
Schistosoma mansoni amine GPCR 0.0009 0.0101 0.0101
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0023 0.0539 0.2076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Echinococcus granulosus hypothetical protein 0.0009 0.0101 0.0101
Schistosoma mansoni alpha-1 adrenergic receptor 0.0009 0.0101 0.0101
Trypanosoma brucei cytochrome P450, putative 0.0008 0.0057 0.0567
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0593 0.3352
Onchocerca volvulus 0.0009 0.0101 0.0186
Brugia malayi follicle stimulating hormone receptor 0.0009 0.0101 0.039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Onchocerca volvulus 0.007 0.2001 1
Onchocerca volvulus 0.0009 0.0101 0.0186
Brugia malayi intermediate filament protein 0.0029 0.0725 0.2792
Onchocerca volvulus 0.0063 0.177 0.8807
Brugia malayi G-protein coupled receptor 0.0009 0.0101 0.039
Brugia malayi hypothetical protein 0.0009 0.0101 0.039
Echinococcus multilocularis somatostatin receptor 0.0009 0.0101 0.0101
Onchocerca volvulus 0.0038 0.101 0.4884
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0101 0.0101
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0009 0.0101 0.0101
Echinococcus granulosus neuropeptide receptor 0.0009 0.0101 0.0101
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0101 0.0101
Brugia malayi putative neuropeptide receptor NPR1 0.0009 0.0101 0.039
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0101 0.0101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0101 0.0101
Trichomonas vaginalis set domain proteins, putative 0.0063 0.1769 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0023 0.0539 0.0539
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0023 0.0539 0.5055
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0009 0.0095 0.0539
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0101 0.0101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0101 0.0101
Schistosoma mansoni hypothetical protein 0.0009 0.0101 0.0101
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.101 0.5713
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0101 0.0101
Plasmodium falciparum importin beta, putative 0.0031 0.0773 1
Mycobacterium leprae Probable lipase LipE 0.0038 0.101 1
Plasmodium vivax SET domain protein, putative 0.0008 0.0065 0.0646
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Echinococcus granulosus orexin receptor type 2 0.0009 0.0101 0.0101
Echinococcus granulosus lamin dm0 0.0029 0.0725 0.0725
Loa Loa (eye worm) carbonic anhydrase 3 0.0023 0.0539 0.0539
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0101 0.0101
Schistosoma mansoni opsin-like receptor 0.0009 0.0101 0.0101
Schistosoma mansoni hypothetical protein 0.0008 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0014 0.024 0.024
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0773 0.7653
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0009 0.0101 0.0101
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0101 0.0101
Echinococcus multilocularis 0.0008 0.0057 0.0057
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.101 0.101
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0773 0.7653
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0023 0.0539 0.2076
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.101 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0009 0.0101 0.0101
Echinococcus granulosus g protein coupled receptor 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Echinococcus granulosus 7TM GPCR rhodopsin 0.0009 0.0101 0.0101
Schistosoma mansoni neuropeptide f receptor 76f 0.0009 0.0101 0.0101
Trichomonas vaginalis threonine dehydratase/deaminase, putative 0.0026 0.0628 0.3548
Schistosoma mansoni carbonic anhydrase 0.0023 0.0539 0.0539
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.101 0.101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.101 0.3891
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Echinococcus granulosus fmrfamide receptor 0.0009 0.0101 0.0101
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0101 0.0101
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0008 0.0065 0.0065
Onchocerca volvulus 0.0009 0.0101 0.0186
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0101 0.0101
Plasmodium vivax hypothetical protein, conserved 0.0038 0.101 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0593 0.3352
Schistosoma mansoni carbonic anhydrase-related 0.0023 0.0539 0.0539
Echinococcus granulosus g protein coupled receptor 0.0009 0.0101 0.0101
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.101 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0141 0.419 0.419
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0327 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0101 0.0101
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0101 0.0101
Echinococcus granulosus jun protein 0.0089 0.2597 0.2597
Echinococcus granulosus nuclear factor of activated T cells 5 0.0019 0.0426 0.0426
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0008 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0009 0.0101 0.0101
Onchocerca volvulus 0.0009 0.0101 0.0186
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0023 0.0539 0.5055
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0101 0.0101
Echinococcus granulosus G protein coupled receptor 139 0.0009 0.0101 0.0101
Mycobacterium ulcerans lipase LipD 0.0038 0.101 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0521 0.0521
Brugia malayi beta-lactamase family protein 0.0038 0.101 0.3891
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0101 0.0101
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.101 0.1293
Schistosoma mansoni lamin 0.0029 0.0725 0.0725
Echinococcus granulosus carbonic anhydrase 0.0023 0.0539 0.0539
Loa Loa (eye worm) cytochrome P450 0.0008 0.0057 0.0057
Brugia malayi hypothetical protein 0.0009 0.0101 0.039
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0009 0.0101 0.0101
Onchocerca volvulus 0.0029 0.0725 0.3409
Schistosoma mansoni opsin-like receptor 0.0009 0.0101 0.0101
Echinococcus multilocularis allatostatin A receptor 0.0009 0.0101 0.0101
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0521 0.4871
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Brugia malayi Dopamine receptor protein 1 0.0009 0.0101 0.039
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0009 0.0101 0.0101
Brugia malayi Cytochrome P450 family protein 0.0008 0.0057 0.0221
Mycobacterium tuberculosis Conserved protein 0.0038 0.101 0.1293
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Schistosoma mansoni cytochrome P450 0.0008 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Leishmania major cytochrome p450-like protein 0.0008 0.0057 0.0567
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0101 0.0101
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0009 0.0101 0.0101
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0101 0.0101
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0009 0.0095 0.0095
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0009 0.0095 0.0095
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Brugia malayi Sex muscle abnormal protein 5 0.0019 0.0423 0.1631
Loa Loa (eye worm) hypothetical protein 0.0063 0.1765 0.1765
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0009 0.0095 0.0943
Schistosoma mansoni neuropeptide receptor 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0038 0.101 0.101
Trypanosoma cruzi serine-threonine dehydratase, putative 0.0026 0.0628 0.5984
Echinococcus granulosus g-protein coupled receptor 0.0009 0.0101 0.0101
Loa Loa (eye worm) melatonin receptor type 1A 0.0009 0.0101 0.0101
Echinococcus granulosus alpha 1A adrenergic receptor 0.0009 0.0101 0.0101
Leishmania major importin beta-1 subunit, putative 0.0025 0.0593 0.5868
Schistosoma mansoni hypothetical protein 0.0023 0.0539 0.0539
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0023 0.0539 0.2076
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0593 0.562
Trypanosoma cruzi serine-threonine dehydratase, putative 0.0026 0.0628 0.5984
Echinococcus multilocularis snurportin 1 0.0327 1 1
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0101 0.0101
Onchocerca volvulus Serine racemase homolog 0.0026 0.0628 0.2906
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0725 0.0725
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0101 0.0101
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0257 0.0257
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0009 0.0101 0.0101
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.101 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0009 0.0101 0.0101
Schistosoma mansoni neuropeptide receptor 0.0009 0.0101 0.0101
Entamoeba histolytica threonine dehydratase, putative 0.0026 0.0628 1
Schistosoma mansoni biogenic amine receptor 0.0009 0.0101 0.0101
Schistosoma mansoni biogenic amine receptor 0.0009 0.0101 0.0101
Echinococcus multilocularis carbonic anhydrase 0.0023 0.0539 0.0539
Loa Loa (eye worm) hypothetical protein 0.0038 0.101 0.101
Onchocerca volvulus 0.0029 0.0725 0.3409
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0101 0.0101
Brugia malayi Cytochrome P450 family protein 0.0008 0.0057 0.0221
Entamoeba histolytica hypothetical protein 0.0025 0.0593 0.9447
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0101 0.0101
Brugia malayi hypothetical protein 0.007 0.2001 0.7703
Echinococcus granulosus sex peptide receptor 0.0009 0.0101 0.0101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0101 0.0101
Brugia malayi hypothetical protein 0.0009 0.0101 0.039
Brugia malayi hypothetical protein 0.0009 0.0101 0.039
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0101 0.0101
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0009 0.0101 0.0101
Brugia malayi beta-lactamase family protein 0.0038 0.101 0.3891
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.101 0.1293
Echinococcus granulosus tachykinin peptides receptor 99D 0.0009 0.0101 0.0101
Onchocerca volvulus 0.0038 0.101 0.4884
Echinococcus granulosus carbonic anhydrase 0.0023 0.0539 0.0539
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Brugia malayi hypothetical protein 0.0009 0.0101 0.039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0089 0.2597 0.2597
Brugia malayi hypothetical protein 0.0009 0.0101 0.039
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0009 0.0095 0.0539
Leishmania major hypothetical protein, conserved 0.0038 0.101 1
Brugia malayi Serotonin receptor 0.0009 0.0101 0.039
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0101 0.0101
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.101 0.101
Mycobacterium ulcerans threonine dehydratase 0.0026 0.0628 0.5984
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0009 0.0101 0.039
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0023 0.0539 0.2076
Trypanosoma cruzi protein farnesyltransferase, putative 0.0009 0.0095 0.0398
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0521 0.5161
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Brugia malayi Melatonin receptor type 1A 0.0009 0.0101 0.039
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0009 0.0095 0.1518
Brugia malayi Dopamine receptor 0.0009 0.0101 0.039
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0101 0.0101
Brugia malayi sulfakinin receptor protein 0.0009 0.0101 0.039
Onchocerca volvulus 0.0009 0.0101 0.0186
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0101 0.0101
Echinococcus multilocularis carbonic anhydrase II 0.0023 0.0539 0.0539
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0008 0.0057 0.0567
Schistosoma mansoni hypothetical protein 0.0073 0.2077 0.2077
Schistosoma mansoni hypothetical protein 0.0013 0.0216 0.0216
Echinococcus granulosus survival motor neuron protein 1 0.0063 0.1765 0.1765
Echinococcus granulosus growth factor receptor bound protein 2 0.0019 0.0423 0.0423
Schistosoma mansoni hypothetical protein 0.0327 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0009 0.0101 0.0101
Schistosoma mansoni survival motor neuron protein 0.0013 0.0216 0.0216
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0521 0.4871
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Brugia malayi beta-lactamase 0.0038 0.101 0.3891
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Schistosoma mansoni growth factor receptor-bound protein 0.0019 0.0423 0.0423
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0773 0.7653
Brugia malayi bZIP transcription factor family protein 0.0089 0.2597 1
Echinococcus granulosus intermediate filament protein 0.0029 0.0725 0.0725
Schistosoma mansoni neuropeptide receptor 0.0009 0.0101 0.0101
Trypanosoma cruzi lanosterol synthase, putative 0.001 0.0122 0.0679
Trypanosoma brucei carbonic anhydrase-like protein 0.0023 0.0539 0.5336
Brugia malayi neuropeptide F receptor 0.0009 0.0101 0.039
Leishmania major lanosterol synthase, putative 0.0007 0.0047 0.0468
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0009 0.0095 0.0943
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0773 0.0773
Toxoplasma gondii hypothetical protein 0.0023 0.0539 0.5336
Schistosoma mansoni carbonic anhydrase-related 0.0023 0.0539 0.0539
Schistosoma mansoni biogenic amine (5HT) receptor 0.0141 0.419 0.419
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0101 0.0101
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0008 0.0065 0.0065
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0009 0.0101 0.039
Onchocerca volvulus 0.0009 0.0101 0.0186
Loa Loa (eye worm) hypothetical protein 0.0014 0.024 0.024
Leishmania major carbonic anhydrase-like protein 0.0023 0.0539 0.5336
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0009 0.0101 0.039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0305 0.0305
Schistosoma mansoni biogenic amine receptor 0.0009 0.0101 0.0101
Schistosoma mansoni opsin-like receptor 0.0009 0.0101 0.0101
Echinococcus multilocularis G protein coupled receptor 139 0.0009 0.0101 0.0101
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0057 0.0057
Plasmodium vivax importin-beta 2, putative 0.0031 0.0773 0.7653
Brugia malayi G protein-coupled receptor 0.0009 0.0101 0.039
Brugia malayi hypothetical protein 0.0063 0.1765 0.6798
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0101 0.0101
Echinococcus multilocularis jun protein 0.0089 0.2597 0.2597
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0521 0.0521
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0101 0.0101
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0521 0.6744
Loa Loa (eye worm) hypothetical protein 0.0014 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0023 0.0539 0.0539
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0009 0.0095 0.0943
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0009 0.0101 0.0101
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0023 0.0539 0.2076
Leishmania major cytochrome p450-like protein 0.0008 0.0057 0.0567
Loa Loa (eye worm) hypothetical protein 0.0038 0.101 0.101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Brugia malayi Pyridoxal-phosphate dependent enzyme family protein 0.0026 0.0628 0.2417
Echinococcus multilocularis orexin receptor type 2 0.0009 0.0101 0.0101
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0009 0.0101 0.039
Mycobacterium ulcerans hypothetical protein 0.0038 0.101 1
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0725 0.2792
Schistosoma mansoni threonine dehydratase/deaminase 0.0026 0.0628 0.0628
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0009 0.0095 0.0539
Loa Loa (eye worm) hypothetical protein 0.0038 0.101 0.101
Echinococcus granulosus lamin 0.0029 0.0725 0.0725
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0089 0.2597 0.2597
Echinococcus granulosus carbonic anhydrase 0.0023 0.0539 0.0539
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0009 0.0095 0.0095
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0009 0.0095 0.1232
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0023 0.0539 0.0539
Brugia malayi AKH receptor 0.0009 0.0101 0.039
Plasmodium falciparum carbonic anhydrase 0.0023 0.0539 0.6972
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.101 0.1293
Schistosoma mansoni hypothetical protein 0.0009 0.0101 0.0101
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0023 0.0539 0.2076
Leishmania major GTP-binding protein, putative 0.0023 0.0521 0.5161
Echinococcus granulosus 7tm_1 domain containing protein 0.0009 0.0101 0.0101
Brugia malayi Dopamine receptor protein 2 0.0009 0.0101 0.039
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.101 0.101
Echinococcus multilocularis g-protein coupled receptor 0.0009 0.0101 0.0101
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0013 0.0216 0.0834
Echinococcus granulosus neuropeptide s receptor 0.0009 0.0101 0.0101
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.101 1
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0101 0.0101
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0593 0.3352
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.101 0.1293
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0521 0.5161
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0009 0.0095 0.0095
Onchocerca volvulus 0.0009 0.0101 0.0186
Schistosoma mansoni histamine h1 receptor 0.0009 0.0101 0.0101
Echinococcus multilocularis neuropeptide FF receptor 2 0.0009 0.0101 0.0101
Schistosoma mansoni intermediate filament proteins 0.0029 0.0725 0.0725
Leishmania major serine-threonine dehydratase, putative 0.0026 0.0628 0.6211
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0305 0.1173
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0009 0.0101 0.0101
Echinococcus granulosus allatostatin A receptor 0.0009 0.0101 0.0101
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0009 0.0095 0.0539
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Echinococcus granulosus somatostatin receptor 0.0009 0.0101 0.0101
Mycobacterium ulcerans beta-lactamase 0.0038 0.101 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0101 0.0101
Echinococcus multilocularis growth factor receptor bound protein 2 0.0019 0.0423 0.0423
Brugia malayi G protein-coupled receptor F59B2.13 0.0009 0.0101 0.039
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0008 0.0057 0.0567
Loa Loa (eye worm) hypothetical protein 0.0009 0.0101 0.0101
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0521 0.8007

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) Antimycobacterial activity against Mycobacterium tuberculosis H37Rv at 1.5 to 50 ug/ml after 7 days by resazurin microtiter plate assay ChEMBL. 22119150

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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