TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 487.536 | Formula: C27H31F2NO5
H donors: 2 H acceptors: 4 LogP: 2.92 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C(=O)O.CCCN1[C@@H]2CC[C@H]1C/C(=C/COC(c1ccc(cc1)F)c1ccc(cc1)F)/C2
InChi: 1S/C25H29F2NO.C2H2O4/c1-2-14-28-23-11-12-24(28)17-18(16-23)13-15-29-25(19-3-7-21(26)8-4-19)20-5-9-22(27)10-6-20;3-1(4)2(5)6/h3-10,13,23-25H,2,11-12,14-17H2,1H3;(H,3,4)(H,5,6)/b18-13-;/t23-,24+;/m0./s1
InChiKey: IKGDPWJFXIJTLW-ZNTXWWGHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Transporter	Starlite/ChEMBL	References
Rattus norvegicus	Serotonin transporter	Starlite/ChEMBL	References
Rattus norvegicus	Dopamine transporter	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative	Serotonin transporter	630 aa	581 aa	40.1 %
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Serotonin transporter	630 aa	576 aa	31.8 %
Onchocerca volvulus		Transporter	617 aa	586 aa	37.4 %
Schistosoma mansoni	sodium/chloride dependent transporter	Serotonin transporter	630 aa	605 aa	37.7 %
Schistosoma japonicum	ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative	Serotonin transporter	630 aa	520 aa	36.2 %
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	Dopamine transporter	619 aa	604 aa	37.9 %
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Serotonin transporter	630 aa	582 aa	35.2 %
Echinococcus multilocularis	sodium and chloride dependent glycine	Serotonin transporter	630 aa	617 aa	39.4 %
Echinococcus granulosus	sodium and chloride dependent glycine	Transporter	617 aa	507 aa	38.9 %
Drosophila melanogaster	CG13796 gene product from transcript CG13796-RD	Serotonin transporter	630 aa	638 aa	25.1 %
Echinococcus multilocularis	sodium and chloride dependent glycine	Transporter	617 aa	507 aa	38.9 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	Serotonin transporter	630 aa	576 aa	30.9 %
Neospora caninum	sodium-dependent transporter, putative	Dopamine transporter	619 aa	498 aa	32.3 %
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	Serotonin transporter	630 aa	509 aa	28.3 %
Plasmodium vivax	hypothetical protein, conserved	Serotonin transporter	630 aa	528 aa	21.2 %
Onchocerca volvulus	Transmembrane protein 120 homolog	Serotonin transporter	630 aa	571 aa	31.2 %
Plasmodium knowlesi	transporter, putative	Serotonin transporter	630 aa	514 aa	20.2 %
Onchocerca volvulus	High affinity copper uptake protein 1 homolog	Serotonin transporter	630 aa	629 aa	47.1 %
Drosophila melanogaster	CG1698 gene product from transcript CG1698-RA	Serotonin transporter	630 aa	585 aa	34.2 %
Onchocerca volvulus		Serotonin transporter	630 aa	611 aa	26.4 %
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	Transporter	617 aa	522 aa	22.0 %
Plasmodium falciparum	transporter, putative	Transporter	617 aa	497 aa	21.5 %
Echinococcus granulosus	sodium and chloride dependent glycine	Serotonin transporter	630 aa	617 aa	39.4 %
Schistosoma mansoni	sodium/chloride dependent transporter	Serotonin transporter	630 aa	552 aa	41.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.005	0.003	0.0091
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.1705	0.3251	1
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0078	0.0086	0.0174
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0086	0.0009
Entamoeba histolytica	protein kinase, putative	0.1705	0.3251	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0031	0.0095
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0292	0.0501	0.1542
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0052	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.003	0.0091
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.005	0.003	0.008
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0077	0.0083	0.0244
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.003	0.008
Trichomonas vaginalis	CMGC family protein kinase	0.1705	0.3251	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0052	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0086	0.0009
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.005	0.003	0.008
Brugia malayi	hypothetical protein	0.0123	0.0173	0.0239
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0149	0.0223	0.0675
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0077	0.0083	0.0244
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.1705	0.3251	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0031	0.0095
Plasmodium falciparum	glycogen synthase kinase 3	0.1705	0.3251	1
Entamoeba histolytica	hypothetical protein	0.0183	0.0289	0.088
Brugia malayi	hypothetical protein	0.005	0.003	0.0041
Loa Loa (eye worm)	hypothetical protein	0.005	0.003	0.0091
Echinococcus multilocularis	aurora kinase A	0.0078	0.0086	0.0252
Trichomonas vaginalis	CMGC family protein kinase	0.1705	0.3251	1
Loa Loa (eye worm)	runx1	0.0056	0.0042	0.013
Leishmania major	telomerase reverse transcriptase, putative	0.1413	0.2683	0.8223
Schistosoma mansoni	sodium/chloride dependent transporter	0.0066	0.0062	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0292	0.0501	0.1542
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.003	0.0091
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.023	0.0381	0.1161
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0077	0.0083	0.0042
Entamoeba histolytica	protein kinase, putative	0.0078	0.0086	0.0252
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0086	0.0009
Onchocerca volvulus		0.0292	0.0501	0.0473
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0223	0.0368	0.112
Schistosoma mansoni	protein kinase	0.0078	0.0086	0.0263
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0149	0.0223	0.0308
Leishmania major	protein kinase, putative	0.0078	0.0086	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0446	0.0802	0.2466
Brugia malayi	hypothetical protein	0.0446	0.0802	0.1106
Echinococcus granulosus	protein kinase shaggy	0.1705	0.3251	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.003	0.008
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.003	0.0091
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.003	0.008
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.023	0.0381	0.094
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.003	0.0091
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.1705	0.3251	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0052	0.0149
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0183	0.0289	0.088
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.003	0.008
Entamoeba histolytica	protein kinase domain containing protein	0.1705	0.3251	1
Onchocerca volvulus		0.0446	0.0802	0.0774
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.003	0.0091
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.023	0.0381	0.094
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.1705	0.3251	1
Brugia malayi	hypothetical protein	0.0036	0.0004	0.0005
Toxoplasma gondii	aurora kinase	0.0078	0.0086	0.0174
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.1705	0.3251	1
Echinococcus granulosus	aurora kinase A	0.0078	0.0086	0.0252
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.1705	0.3251	1
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.005	0.003	0.008
Schistosoma mansoni	sodium-dependent amino acid transporter	0.005	0.003	0.0091
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0078	0.0086	0.0252
Onchocerca volvulus	Huntingtin homolog	0.0123	0.0173	0.0144
Echinococcus multilocularis	serotonin transporter	0.0292	0.0501	0.1532
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.023	0.0381	0.094
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.003	0.0091
Onchocerca volvulus	Huntingtin homolog	0.0123	0.0173	0.0144
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0077	0.0083	0.0114
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.003	0.008
Entamoeba histolytica	protein kinase , putative	0.0078	0.0086	0.0252
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0158	0.0241	0.0498
Plasmodium vivax	glycogen synthase kinase 3, putative	0.1705	0.3251	1
Loa Loa (eye worm)	hypothetical protein	0.0292	0.0501	0.1542
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.005	0.003	0.0041
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.023	0.0381	0.0978
Giardia lamblia	Kinase, CMGC GSK	0.1705	0.3251	1
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0078	0.0086	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0091	0.028
Plasmodium falciparum	telomerase reverse transcriptase	0.1413	0.2683	0.8236
Loa Loa (eye worm)	hypothetical protein	0.005	0.003	0.0091
Brugia malayi	serine/threonine-protein kinase 6	0.0078	0.0086	0.0118
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0817	0.1523	0.4679
Trypanosoma cruzi	aurora B kinase, putative	0.0078	0.0086	0.005
Giardia lamblia	Aurora kinase	0.0078	0.0086	0.0149
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0052	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0052	0.5
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.1413	0.2683	0.8214
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0149	0.0223	0.0675
Schistosoma mansoni	lozenge	0.0056	0.0042	0.013
Plasmodium vivax	telomerase reverse transcriptase, putative	0.1413	0.2683	0.8236
Echinococcus granulosus	serotonin transporter	0.0292	0.0501	0.1532
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.023	0.0381	0.1161
Loa Loa (eye worm)	norepinephrine transporter	0.0292	0.0501	0.1542
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0078	0.0086	0.0252
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0158	0.0241	0.0498
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0031	0.0043
Entamoeba histolytica	protein kinase domain containing protein	0.0078	0.0086	0.0252
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0111	0.0149	0.0346
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.003	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0173	0.0533
Brugia malayi	serine/threonine protein kinase 6	0.0078	0.0086	0.0118
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0292	0.0501	0.0691
Brugia malayi	serine/threonine kinase 12	0.0078	0.0086	0.0118
Loa Loa (eye worm)	hypothetical protein	0.005	0.003	0.0091
Schistosoma mansoni	serine/threonine protein kinase	0.0078	0.0086	0.0263
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.005	0.003	0.008
Schistosoma mansoni	hypothetical protein	0.0036	0.0004	0.0011
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0052	0.0161
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.023	0.0381	0.0525
Onchocerca volvulus		0.1705	0.3251	0.3231
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.023	0.0381	0.1171
Loa Loa (eye worm)	phosphatidylinositol 3	0.007	0.007	0.0214
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0292	0.0501	0.1542
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.003	0.0041
Echinococcus multilocularis	Protein lozenge	0.0056	0.0042	0.0118
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.023	0.0381	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0446	0.0802	0.2466
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0078	0.0086	0.0252
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.1705	0.3251	1
Giardia lamblia	Telomerase catalytic subunit	0.1413	0.2683	0.8231
Loa Loa (eye worm)	hypothetical protein	0.0149	0.0223	0.0686
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0078	0.0086	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0173	0.0533
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0102	0.0132	0.0394
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0086	0.0009
Brugia malayi	Telomerase reverse transcriptase	0.3761	0.725	1
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.005	0.003	0.008
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.1413	0.2683	0.8214
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.1705	0.3251	1
Brugia malayi	intracellular kinase	0.1705	0.3251	0.4484
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0052	0.007
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0078	0.0086	0.0174
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.003	0.0041
Loa Loa (eye worm)	serotonin transporter b	0.0292	0.0501	0.1542
Toxoplasma gondii	RNA-directed DNA polymerase	0.1413	0.2683	0.8236
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.003	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0292	0.0501	0.1542
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0052	0.0161
Entamoeba histolytica	protein kinase domain containing protein	0.1705	0.3251	1
Trypanosoma brucei	aurora B kinase	0.0078	0.0086	0.0009
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.003	0.0091
Schistosoma mansoni	sodium/chloride dependent transporter	0.005	0.003	0.0091
Giardia lamblia	Kinase, CMGC GSK	0.1705	0.3251	1
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.003	0.008
Loa Loa (eye worm)	hypothetical protein	0.005	0.003	0.0091
Echinococcus multilocularis	protein kinase shaggy	0.1705	0.3251	1
Loa Loa (eye worm)	AUR protein kinase	0.0078	0.0086	0.0263
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0031	0.0043
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.003	0.0091
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.005	0.003	0.5
Trypanosoma brucei	protein kinase, putative	0.1705	0.3251	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0052	0.0149
Entamoeba histolytica	protein kinase, putative	0.0078	0.0086	0.0252
Schistosoma mansoni	sodium/chloride dependent transporter	0.0292	0.0501	0.1542
Loa Loa (eye worm)	phosphatidylinositol 3	0.0183	0.0289	0.089
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.003	0.0091
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.003	0.0091
Trypanosoma brucei	telomerase reverse transcriptase	0.1413	0.2683	0.8206
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0004	0.0011
Treponema pallidum	sodium- and chloride- dependent transporter	0.0292	0.0501	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.003	0.0091
Loa Loa (eye worm)	AUR protein kinase	0.0078	0.0086	0.0263
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.023	0.0381	0.1161
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0077	0.0083	0.0255
Loa Loa (eye worm)	AUR protein kinase	0.0078	0.0086	0.0263

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 41 nM	Displacement of [3H]WIN35428 from DAT in Sprague-Dawley rat brain homogenates after 1 hr by scintillation counting	ChEMBL.	22055716
Ki (binding)	= 2847 nM	Displacement of [3H]nisoxetine from NET in Sprague-Dawley rat brain cortex membranes after 1 hr	ChEMBL.	22055716
Ki (binding)	= 5463 nM	Displacement of [3H]citalopram from SERT in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting	ChEMBL.	22055716

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1927871

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1598330