Detailed information for compound 1606607

Basic information

Technical information
  • TDR Targets ID: 1606607
  • Name: 1-methyl-1-(2-pyridin-2-ylethyl)-3-(pyridin-2 -ylmethylideneamino)thiourea
  • MW: 299.394 | Formula: C15H17N5S
  • H donors: 1 H acceptors: 2 LogP: 1.97 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=S)N/N=C/c1ccccn1)CCc1ccccn1
  • InChi: 1S/C15H17N5S/c1-20(11-8-13-6-2-4-9-16-13)15(21)19-18-12-14-7-3-5-10-17-14/h2-7,9-10,12H,8,11H2,1H3,(H,19,21)/b18-12+
  • InChiKey: KQFOTJZIJFADKP-LDADJPATSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-methyl-1-[2-(2-pyridyl)ethyl]-3-(2-pyridylmethyleneamino)thiourea
  • AIDS-161093
  • NSC670780
  • AIDS161093
  • NCI60_024930
  • 2-Pyridinecarbaldehyde N-methyl-N-(2-(2-pyridinyl)ethyl)thiosemicarbazone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Echinococcus multilocularis protein tyrosine phosphatase, non receptor type 0.0206 0.0108 0.011
Trypanosoma brucei DNA topoisomerase ii 0.034 0.0184 0.0527
Trypanosoma brucei heat shock protein, putative 0.034 0.0184 0.0527
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.034 0.0184 0.0527
Brugia malayi Unc-112 related protein. 0.0206 0.0108 0.0108
Entamoeba histolytica tyrosin kinase, putative 0.0073 0.0032 0.1677
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0073 0.0032 0.0033
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Echinococcus granulosus activated cdc42 kinase 1 0.0073 0.0032 0.0033
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Plasmodium vivax endoplasmin, putative 0.034 0.0184 1
Onchocerca volvulus 0.0206 0.0108 0.4999
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0052 0.0021 0.0021
Brugia malayi Ferm domain (protein4.1-ezrin-radixin-moesin) family protein 4-like 0.0206 0.0108 0.0108
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0073 0.0032 0.1677
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Schistosoma mansoni talin 0.0206 0.0108 0.011
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Plasmodium vivax tyrosine kinase-like protein, putative 0.0073 0.0032 0.1677
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Trypanosoma cruzi heat shock protein 85, putative 0.034 0.0184 0.0527
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0073 0.0032 0.1677
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.6113 0.3464 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Trypanosoma cruzi Heat shock protein 83, putative 0.034 0.0184 0.0527
Echinococcus granulosus tyrosine protein kinase Blk 0.0073 0.0032 0.0033
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Trichomonas vaginalis heat shock protein, putative 0.034 0.0184 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0002 0.0002
Schistosoma mansoni protein tyrosine kinase 0.0073 0.0032 0.0033
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0005 0.0201
Trichomonas vaginalis STE family protein kinase 0.0073 0.0032 0.1677
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.6113 0.3464 0.3505
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.034 0.0184 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Brugia malayi Endoplasmin precursor 0.034 0.0184 0.0184
Giardia lamblia Kinase 0.0073 0.0032 0.1677
Trypanosoma cruzi heat shock protein 90, putative 0.034 0.0184 0.0527
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0015 0.0736
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.0032 0.0033
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Brugia malayi CHE-14 protein 0.0043 0.0015 0.0015
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus granulosus SPRY domain containing protein 0.0206 0.0108 0.011
Schistosoma mansoni merlin/moesin/ezrin/radixin 0.0206 0.0108 0.011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.034 0.0184 0.0184
Schistosoma mansoni hypothetical protein 0.0041 0.0014 0.0014
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.034 0.0184 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0073 0.0032 0.0033
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Plasmodium falciparum heat shock protein 90 0.034 0.0184 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.0032 0.0033
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Echinococcus multilocularis activin receptor type 0.0073 0.0032 0.0033
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.034 0.0184 1
Giardia lamblia Kinase, NEK 0.0073 0.0032 0.1677
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.034 0.0184 1
Brugia malayi DNA topoisomerase II, alpha isozyme 0.034 0.0184 0.0184
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Schistosoma mansoni merlin/moesin/ezrin/radixin 0.0206 0.0108 0.011
Echinococcus multilocularis tyrosine protein kinase pr2 0.0073 0.0032 0.0033
Brugia malayi hypothetical protein 0.0025 0.0005 0.0005
Plasmodium vivax hypothetical protein, conserved 0.034 0.0184 1
Echinococcus multilocularis radixin 0.0206 0.0108 0.011
Echinococcus granulosus tyrosine protein kinase Fyn 0.0073 0.0032 0.0033
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0073 0.0032 0.0088
Schistosoma mansoni hypothetical protein 0.0041 0.0014 0.0014
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0015 0.0015
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.001 0.001
Trypanosoma brucei heat shock protein, putative 0.034 0.0184 0.0527
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.0032 0.0032
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.0032 0.0033
Echinococcus granulosus fibroblast growth factor receptor 4 0.0073 0.0032 0.0033
Echinococcus granulosus muscleblind protein 0.0151 0.0077 0.0077
Mycobacterium leprae Probable two component sensor kinase MprB 0.034 0.0184 0.5
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0073 0.0032 0.0032
Toxoplasma gondii protein kinase 0.0073 0.0032 0.0219
Trichomonas vaginalis heat shock protein, putative 0.034 0.0184 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.034 0.0184 1
Echinococcus granulosus tyrosine protein kinase shark 0.0073 0.0032 0.0033
Trypanosoma cruzi heat shock protein 85, putative 0.034 0.0184 0.0527
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0073 0.0032 0.0033
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Echinococcus granulosus FERM domain containing protein 3 0.0206 0.0108 0.011
Echinococcus granulosus activated cdc42 kinase 1 0.0073 0.0032 0.0033
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0073 0.0032 0.0033
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0073 0.0032 0.0032
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.034 0.0184 1
Loa Loa (eye worm) SRC-1 0.0073 0.0032 0.0032
Echinococcus granulosus tyrosine protein kinase ABL1 0.0073 0.0032 0.0033
Schistosoma mansoni ephrin receptor 0.0073 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Echinococcus granulosus FERM central domain 0.0206 0.0108 0.011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Echinococcus granulosus FERM central domain 0.0206 0.0108 0.011
Loa Loa (eye worm) serine/threonine protein kinase 0.0073 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0108 0.5838
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Schistosoma mansoni ephrin receptor 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0073 0.0032 0.0219
Schistosoma mansoni tyrosine protein kinase 0.0073 0.0032 0.0033
Leishmania major developmentally regulated phosphoprotein-like protein 0.6113 0.3464 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Entamoeba histolytica receptor protein kinase, putative 0.0073 0.0032 0.1677
Brugia malayi bone morphogenetic protein type 1 receptor 0.0073 0.0032 0.0032
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trichomonas vaginalis receptor histidine kinase, putative 0.034 0.0184 1
Echinococcus multilocularis protein kinase 0.0073 0.0032 0.0033
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Echinococcus granulosus activin receptor type 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus multilocularis H17g protein, tegumental antigen 0.0206 0.0108 0.011
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0073 0.0032 0.0033
Echinococcus granulosus heat shock protein 0.034 0.0184 0.0186
Trypanosoma brucei Pseudokinase, putative 0.0073 0.0032 0.0088
Brugia malayi neurofibromatosis homolog protein 1 0.0206 0.0108 0.0108
Trypanosoma brucei DNA topoisomerase II beta, putative 0.034 0.0184 0.0527
Entamoeba histolytica serine/threonine kinase, putative 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Leishmania major protein kinase, putative 0.0073 0.0032 0.0088
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0047 0.0047
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Treponema pallidum chemotaxis histidine kinase (cheA) 0.034 0.0184 1
Onchocerca volvulus 0.0206 0.0108 0.4999
Trypanosoma cruzi DNA topoisomerase II, putative 0.034 0.0184 0.0527
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0032 0.1677
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0108 0.5838
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.2477 0.1398 1
Echinococcus granulosus protein tyrosine kinase 1.7413 0.9883 1
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Mycobacterium leprae Probable two-component sensor kinase 0.034 0.0184 0.5
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.6113 0.3464 0.3505
Echinococcus granulosus c src tyrosine kinase 0.0073 0.0032 0.0033
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0005 0.0011
Trichomonas vaginalis DNA topoisomerase II, putative 0.034 0.0184 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0206 0.0108 0.011
Plasmodium falciparum protein kinase, putative 0.0073 0.0032 0.1677
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Echinococcus granulosus Ezrin radixin moesin ERM 0.0206 0.0108 0.011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0017 0.0017
Leishmania major hypothetical protein, conserved 0.0025 0.0005 0.0011
Trypanosoma cruzi hypothetical protein 0.0206 0.0108 0.0308
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Entamoeba histolytica hypothetical protein, conserved 0.0073 0.0032 0.1677
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0073 0.0032 0.0032
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0073 0.0032 0.0033
Brugia malayi SRC-1 0.0073 0.0032 0.0032
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.034 0.0184 1
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0073 0.0032 0.0032
Echinococcus multilocularis SPRY domain containing protein 0.0206 0.0108 0.011
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.034 0.0184 1
Brugia malayi GRP1 binding protein 0.0206 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Echinococcus multilocularis receptor type guanylyl cyclase 0.0073 0.0032 0.0033
Trichomonas vaginalis protein MLP1, putative 0.0206 0.0108 0.5838
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Echinococcus granulosus talin 2 0.0206 0.0108 0.011
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Trichomonas vaginalis protein tyrosine kinase, putative 0.0073 0.0032 0.1677
Onchocerca volvulus Putative 4.1 G protein 0.0206 0.0108 0.4999
Echinococcus granulosus tyrosine kinase 0.0073 0.0032 0.0033
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0073 0.0032 0.0033
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0073 0.0032 0.0033
Echinococcus multilocularis protein dispatched 1 0.0049 0.0019 0.0019
Echinococcus multilocularis FL cytokine receptor 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0099 0.0047 0.0047
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Leishmania major DNA topoisomerase ii 0.034 0.0184 0.0527
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Brugia malayi SH2 domain containing protein 0.0073 0.0032 0.0032
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0015 0.0015
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Brugia malayi hypothetical protein 0.0206 0.0108 0.0108
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Onchocerca volvulus 0.0206 0.0108 0.4999
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0005 0.0201
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Echinococcus multilocularis protein tyrosine kinase 1.7413 0.9883 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Trypanosoma brucei Heat shock protein 83, putative 0.034 0.0184 0.0527
Echinococcus granulosus myosin viia 0.0206 0.0108 0.011
Brugia malayi Furin-like cysteine rich region family protein 0.0073 0.0032 0.0032
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Echinococcus multilocularis merlin:moesin:ezrin:radixin 0.0206 0.0108 0.011
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0073 0.0032 0.1677
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0032 0.1677
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0073 0.0032 0.0033
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.0032 0.0033
Loa Loa (eye worm) protein kinase domain-containing protein 0.0073 0.0032 0.0032
Echinococcus multilocularis muscleblind protein 1 0.0151 0.0077 0.0077
Loa Loa (eye worm) MyTH4 domain-containing protein 0.0206 0.0108 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0206 0.0108 0.011
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Echinococcus granulosus unc 112 protein 0.0206 0.0108 0.011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.034 0.0184 0.5
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Echinococcus granulosus tyrosine protein kinase Src64B 0.0073 0.0032 0.0033
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Echinococcus granulosus radixin 0.0206 0.0108 0.011
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.034 0.0184 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus multilocularis activated cdc42 kinase 1 0.0073 0.0032 0.0033
Echinococcus granulosus protein 4.1 0.0206 0.0108 0.011
Trichomonas vaginalis endoplasmin, putative 0.034 0.0184 1
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.6113 0.3464 0.3505
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0005 0.0011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.034 0.0184 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.0072 0.0072
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Loa Loa (eye worm) TK/ABL protein kinase 0.0073 0.0032 0.0032
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0073 0.0032 0.0033
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0005 0.0026
Echinococcus granulosus SPRY domain containing protein 0.0206 0.0108 0.011
Schistosoma mansoni pyruvate dehydrogenase 0.5773 0.3271 0.3309
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0073 0.0032 0.0033
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0206 0.0108 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0017 0.0017
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0073 0.0032 0.0033
Echinococcus granulosus tyrosine kinase 0.0073 0.0032 0.0033
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.034 0.0184 0.5
Echinococcus granulosus receptor type guanylyl cyclase 0.0073 0.0032 0.0033
Echinococcus granulosus kinase suppressor of Ras 1 0.0073 0.0032 0.0033
Brugia malayi MyTH4 domain containing protein 0.0206 0.0108 0.0108
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Echinococcus multilocularis myosin viia 0.0206 0.0108 0.011
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Brugia malayi SH2 domain containing protein 0.0073 0.0032 0.0032
Entamoeba histolytica DNA topoisomerase II, putative 0.034 0.0184 1
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.034 0.0184 1
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Mycobacterium tuberculosis Possible two component sensor kinase 0.034 0.0184 1
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0073 0.0032 0.0033
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0073 0.0032 0.0032
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0182 0.0094 0.0094
Brugia malayi protein-tyrosine kinase 0.0073 0.0032 0.0032
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.034 0.0184 1
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0015 0.0015
Trypanosoma cruzi heat shock protein 85, putative 0.034 0.0184 0.0527
Echinococcus multilocularis ephrin type A receptor 4 A 0.0073 0.0032 0.0033
Echinococcus multilocularis protein patched 0.0043 0.0015 0.0015
Echinococcus multilocularis heat shock protein 0.034 0.0184 0.0186
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0047 0.2501
Echinococcus multilocularis 0.0206 0.0108 0.011
Loa Loa (eye worm) TK/CSK protein kinase 0.0073 0.0032 0.0032
Leishmania major hypothetical protein, conserved 0.0073 0.0032 0.0088
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.0032 0.0033
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0073 0.0032 0.0033
Echinococcus granulosus retinal guanylyl cyclase 2 0.0073 0.0032 0.0033
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.034 0.0184 1
Entamoeba histolytica filopodin, putative 0.0206 0.0108 0.5838
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Echinococcus multilocularis protein kinase 0.0073 0.0032 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0032 0.0033
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Plasmodium vivax heat shock protein 86, putative 0.034 0.0184 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0073 0.0032 0.0033
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0073 0.0032 0.0033
Brugia malayi hypothetical protein 0.0073 0.0032 0.0032
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0206 0.0108 0.011
Echinococcus multilocularis FERM domain containing protein 5 0.0206 0.0108 0.011
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.034 0.0184 1
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Echinococcus multilocularis tyrosine kinase 0.0073 0.0032 0.0033
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.034 0.0184 0.0186
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Brugia malayi Receptor family ligand binding region containing protein 0.0073 0.0032 0.0032
Plasmodium falciparum tyrosine kinase-like protein 0.0073 0.0032 0.1677
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0002 0.0002
Echinococcus multilocularis heat shock protein 70 0.0073 0.0032 0.0033
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.034 0.0184 0.1306
Echinococcus granulosus tyrosine protein kinase Fyn 0.0073 0.0032 0.0033
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Mycobacterium tuberculosis Probable two component sensor kinase 0.034 0.0184 1
Echinococcus multilocularis FERM domain containing protein 3 0.0206 0.0108 0.011
Loa Loa (eye worm) TK/DDR protein kinase 0.0073 0.0032 0.0032
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Brugia malayi kinase, mitochondrial precursor 0.6113 0.3464 0.3464
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.005 0.002 0.002
Onchocerca volvulus 0.0206 0.0108 0.4999
Brugia malayi Ferm domain 0.0206 0.0108 0.0108
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.002 0.002
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0073 0.0032 0.0033
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0073 0.0032 0.0033
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0073 0.0032 0.0088
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Echinococcus granulosus DNA topoisomerase 2 alpha 0.034 0.0184 0.0186
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.0032 0.0032
Plasmodium falciparum protein kinase, putative 0.0073 0.0032 0.1677
Schistosoma mansoni merlin/moesin/ezrin/radixin 0.0206 0.0108 0.011
Brugia malayi hypothetical protein 0.0206 0.0108 0.0108
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0073 0.0032 0.0033
Echinococcus multilocularis kinase suppressor of Ras 1 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Toxoplasma gondii STE kinase 0.0073 0.0032 0.0219
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni ap endonuclease 0.0019 0.0002 0.0002
Brugia malayi Muscleblind-like protein 0.0151 0.0077 0.0077
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.034 0.0184 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0073 0.0032 0.0032
Echinococcus granulosus ezrin 0.0206 0.0108 0.011
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.034 0.0184 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Schistosoma mansoni Radixin 0.0206 0.0108 0.011
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0073 0.0032 0.0033
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.034 0.0184 1
Schistosoma mansoni endoplasmin 0.034 0.0184 0.0186
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Chlamydia trachomatis DNA gyrase subunit B 0.034 0.0184 0.5
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Schistosoma mansoni ap endonuclease 0.0019 0.0002 0.0002
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.0032 0.0033
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Brugia malayi Probable DNA topoisomerase II 0.034 0.0184 0.0184
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.002 0.002
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.034 0.0184 0.0527
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Entamoeba histolytica leucine-rich repeat containing protein 0.0206 0.0108 0.5838
Echinococcus granulosus FERM domain containing protein 5 0.0206 0.0108 0.011
Schistosoma mansoni serine/threonine RGC 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0032 0.1677
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0073 0.0032 0.0032
Echinococcus granulosus epidermal growth factor receptor 0.0073 0.0032 0.0033
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0073 0.0032 0.0033
Trypanosoma brucei Flagellum attachment zone protein 20 0.0073 0.0032 0.0088
Trypanosoma cruzi protein kinase, putative 0.0073 0.0032 0.0088
Echinococcus granulosus integrin linked protein kinase 0.0073 0.0032 0.0033
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0206 0.0108 0.011
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.034 0.0184 1
Plasmodium falciparum DNA gyrase subunit B 0.034 0.0184 1
Giardia lamblia Kinase, NEK 0.0073 0.0032 0.1677
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0073 0.0032 0.0032
Echinococcus multilocularis FERM domain containing protein 3 0.0206 0.0108 0.011
Toxoplasma gondii heat shock protein HSP90 0.034 0.0184 0.1306
Onchocerca volvulus DNA topoisomerase 2 homolog 0.034 0.0184 1
Trypanosoma brucei heat shock protein, putative 0.034 0.0184 0.0527
Echinococcus multilocularis ezrin 0.0206 0.0108 0.011
Brugia malayi integrin-linked kinase 0.0073 0.0032 0.0032
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.0032 0.0032
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0206 0.0108 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0032 0.1677
Toxoplasma gondii DNA topoisomerase 2, putative 0.034 0.0184 0.1306
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Loa Loa (eye worm) TK/ACK protein kinase 0.0073 0.0032 0.0032
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Leishmania major mitochondrial DNA topoisomerase II 0.034 0.0184 0.0527
Entamoeba histolytica cysteine surface protein, putative 0.0073 0.0032 0.1677
Brugia malayi ephrin receptor 1 precursor 0.0073 0.0032 0.0032
Echinococcus granulosus tyrosine protein kinase HCK 0.0073 0.0032 0.0033
Entamoeba histolytica tyrosin kinase, putative 0.0073 0.0032 0.1677
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Chlamydia trachomatis DNA gyrase subunit B 0.034 0.0184 0.5
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.0032 0.0033
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.034 0.0184 0.0527
Entamoeba histolytica heat shock protein 90, putative 0.034 0.0184 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Plasmodium vivax tyrosine kinase-like protein, putative 0.0073 0.0032 0.1677
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0017 0.0017
Entamoeba histolytica serine/threonine kinase, putative 0.0073 0.0032 0.1677
Brugia malayi N-terminal motif family protein 0.0182 0.0094 0.0094
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0032 0.0033
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0073 0.0032 0.0033
Echinococcus multilocularis Ezrin radixin moesin ERM 0.0206 0.0108 0.011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus granulosus raf serine:threonine protein kinase 0.0073 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.0151 0.0077 0.0077
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Echinococcus multilocularis expressed conserved protein 0.0093 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0032 0.1677
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.0072 0.0072
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0002 0.0002
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0073 0.0032 0.0033
Schistosoma mansoni hypothetical protein 0.0034 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Giardia lamblia Protein 21.1 0.0073 0.0032 0.1677
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Giardia lamblia Pms1-like protein 0.034 0.0184 1
Brugia malayi Guanylyl cyclase protein 23 0.0073 0.0032 0.0032
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0073 0.0032 0.0219
Trichomonas vaginalis protein kinase atn1, putative 0.0073 0.0032 0.1677
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0073 0.0032 0.0088
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Echinococcus multilocularis integrin linked protein kinase 0.0073 0.0032 0.0033
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.034 0.0184 1
Leishmania major protein kinase, putative 0.0073 0.0032 0.0088
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Echinococcus granulosus expressed conserved protein 0.0093 0.0044 0.0044
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0073 0.0032 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0017 0.0017
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Mycobacterium ulcerans putative regultory protein 0.034 0.0184 1
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0108 0.5838
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.034 0.0184 1
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Plasmodium falciparum protein kinase, putative 0.0073 0.0032 0.1677
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.034 0.0184 1
Schistosoma mansoni DNA topoisomerase II 0.034 0.0184 0.0186
Schistosoma mansoni heat shock protein 0.034 0.0184 0.0186
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Echinococcus granulosus tyrosine protein kinase pr2 0.0073 0.0032 0.0033
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0073 0.0032 0.0032
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0073 0.0032 0.0033
Brugia malayi Ferm domain 0.0206 0.0108 0.0108
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0073 0.0032 0.0088
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Loa Loa (eye worm) moesin 0.0206 0.0108 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0073 0.0032 0.0032
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0073 0.0032 0.0033
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.034 0.0184 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0073 0.0032 0.0033
Echinococcus multilocularis insulin receptor 0.0073 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0017 0.0017
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Plasmodium vivax protein kinase, putative 0.0073 0.0032 0.1677
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0032 0.1677
Entamoeba histolytica receptor protein kinase, putative 0.0073 0.0032 0.1677
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica heat shock protein 90, putative 0.034 0.0184 1
Schistosoma mansoni hypothetical protein 0.0073 0.0032 0.0033
Brugia malayi Tyrosine-protein kinase PR2 0.0073 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0108 0.5838
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Echinococcus granulosus epidermal growth factor receptor 0.0073 0.0032 0.0033
Loa Loa (eye worm) TK/EGFR protein kinase 0.0073 0.0032 0.0032
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.034 0.0184 0.1306
Loa Loa (eye worm) hypothetical protein 0.034 0.0184 0.0184
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Echinococcus granulosus tyrosine kinase 0.0073 0.0032 0.0033
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0073 0.0032 0.1677
Echinococcus multilocularis raf serine:threonine protein kinase 0.0073 0.0032 0.0033
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.2137 0.1205 0.3476
Brugia malayi C-terminal src kinase protein 1 0.0073 0.0032 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Brugia malayi GH28553p 0.0206 0.0108 0.0108
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0073 0.0032 0.0219
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.0032 0.0032
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0073 0.0032 0.0032
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Brugia malayi hypothetical protein 0.0073 0.0032 0.0032
Trypanosoma cruzi ribonuclease inhibitor, putative 0.0206 0.0108 0.0308
Brugia malayi protein-tyrosine-phosphatase 0.0206 0.0108 0.0108
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Plasmodium falciparum tyrosine kinase-like protein 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Mycobacterium ulcerans two component sensor kinase MprB 0.034 0.0184 1
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Plasmodium vivax DNA gyrase subunit B, putative 0.034 0.0184 1
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Echinococcus multilocularis tyrosine protein kinase shark 0.0073 0.0032 0.0033
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0017 0.0017
Onchocerca volvulus 4.1 G protein, putative homolog 0.0206 0.0108 0.4999
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus multilocularis tyrosine protein kinase Blk 0.0073 0.0032 0.0033
Echinococcus multilocularis epidermal growth factor receptor 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0073 0.0032 0.0033
Entamoeba histolytica serine/threonine kinase, putative 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Loa Loa (eye worm) TK/EPH protein kinase 0.0073 0.0032 0.0032
Echinococcus multilocularis FERM central domain 0.0206 0.0108 0.011
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Toxoplasma gondii protein kinase domain-containing protein 0.0073 0.0032 0.0219
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0073 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Brugia malayi Moesin/ezrin/radixin homolog 1 0.0206 0.0108 0.0108
Echinococcus multilocularis tyrosine protein kinase Srms 0.0073 0.0032 0.0033
Trichomonas vaginalis receptor histidine kinase, putative 0.034 0.0184 1
Trichomonas vaginalis sensor histidine kinase, putative 0.034 0.0184 1
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.2137 0.1205 0.3476
Loa Loa (eye worm) TK/Met protein kinase 0.0073 0.0032 0.0032
Trypanosoma cruzi ribonuclease inhibitor, putative 0.0206 0.0108 0.0308
Brugia malayi Talin 1 0.0206 0.0108 0.0108
Echinococcus granulosus FERM domain containing protein 5 0.0206 0.0108 0.011
Plasmodium falciparum DNA topoisomerase 2 0.034 0.0184 1
Trypanosoma brucei heat shock protein, putative 0.034 0.0184 0.0527
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Echinococcus granulosus retinal guanylyl cyclase 2 0.0073 0.0032 0.0033
Trypanosoma cruzi heat shock protein 90, putative 0.034 0.0184 0.0527
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Echinococcus granulosus H17g protein tegumental antigen 0.0206 0.0108 0.011
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Mycobacterium tuberculosis Conserved protein 0.034 0.0184 1
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Echinococcus multilocularis transfer RNA-Thr 0.0073 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.0034 0.001 0.001
Entamoeba histolytica ankyrin repeat protein 0.0073 0.0032 0.1677
Plasmodium vivax DNA topoisomerase II, putative 0.034 0.0184 1
Echinococcus granulosus heat shock protein 90 0.034 0.0184 0.0186
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trypanosoma brucei heat shock protein, putative 0.034 0.0184 0.0527
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Echinococcus multilocularis FERM central domain 0.0206 0.0108 0.011
Echinococcus granulosus natriuretic peptide receptor 1 0.0073 0.0032 0.0033
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.034 0.0184 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0073 0.0032 0.0033
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Echinococcus multilocularis FERM domain containing protein 5 0.0206 0.0108 0.011
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.034 0.0184 1
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.034 0.0184 0.5
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.034 0.0184 0.0527
Echinococcus multilocularis SPRY domain containing protein 0.0206 0.0108 0.011
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0005 0.0201
Trypanosoma brucei developmentally regulated phosphoprotein 0.6113 0.3464 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0073 0.0032 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni talin 2 0.0206 0.0108 0.011
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0073 0.0032 0.0032
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica ankyrin repeat protein 0.0073 0.0032 0.1677
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.2137 0.1205 0.3476
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.034 0.0184 0.0184
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Schistosoma mansoni hypothetical protein 0.0041 0.0014 0.0014
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.0032 0.0032
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0073 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.6113 0.3464 0.3464
Mycobacterium ulcerans two component regulator - sensor kinase 0.034 0.0184 1
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Brugia malayi FERM domain 0.0206 0.0108 0.0108
Echinococcus multilocularis muscleblind protein 0.0151 0.0077 0.0077
Trypanosoma brucei heat shock protein 90, putative 0.034 0.0184 0.0527
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.034 0.0184 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0073 0.0032 0.0033
Trypanosoma brucei heat shock protein, putative 0.034 0.0184 0.0527
Schistosoma mansoni heat shock protein 0.034 0.0184 0.0186
Leishmania major hypothetical protein, conserved 0.034 0.0184 0.0527
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0073 0.0032 0.0033
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0073 0.0032 0.0033
Echinococcus multilocularis protein KINase family member (kin 25) 0.0073 0.0032 0.0033
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Entamoeba histolytica serine/threonine kinase, putative 0.0073 0.0032 0.1677
Echinococcus granulosus Pleckstrin y 0.0206 0.0108 0.011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus granulosus protein tyrosine phosphatase non receptor type 0.0206 0.0108 0.011
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Echinococcus granulosus tyrosine protein kinase Fyn 0.0073 0.0032 0.0033
Loa Loa (eye worm) TK/ALK protein kinase 0.0073 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0041 0.0014 0.0014
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0015 0.0015
Echinococcus granulosus tyrosine protein kinase Lyn 0.0073 0.0032 0.0033
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trypanosoma cruzi DNA topoisomerase II, putative 0.034 0.0184 0.0527
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0002 0.0002
Brugia malayi hypothetical protein 0.0206 0.0108 0.0108
Echinococcus granulosus retinal guanylyl cyclase 2 0.0073 0.0032 0.0033
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0005 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0032 0.1677
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Echinococcus multilocularis heat shock protein 90 0.034 0.0184 0.0186
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0073 0.0032 0.0033
Echinococcus multilocularis tyrosine protein kinase Abl 0.0073 0.0032 0.0033
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0073 0.0032 0.1677
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0073 0.0032 0.1677
Toxoplasma gondii heat shock protein 90, putative 0.034 0.0184 0.1306
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0073 0.0032 0.0033
Mycobacterium tuberculosis Probable sensor protein KdpD 0.034 0.0184 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0047 0.0048
Trypanosoma cruzi protein kinase, putative 0.0073 0.0032 0.0088
Echinococcus multilocularis Pleckstrin y 0.0206 0.0108 0.011
Entamoeba histolytica tyrosin kinase, putative 0.0073 0.0032 0.1677
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0073 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.0043 0.0015 0.0015
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus granulosus SPRY domain containing protein 0.0206 0.0108 0.011
Echinococcus granulosus protein kinase 0.0073 0.0032 0.0033
Echinococcus multilocularis tyrosine protein kinase HCK 0.0073 0.0032 0.0033
Entamoeba histolytica tyrosin kinase, putative 0.0073 0.0032 0.1677
Echinococcus multilocularis talin 0.0206 0.0108 0.011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica serine/threonine kinase, putative 0.0073 0.0032 0.1677
Trypanosoma brucei protein kinase, putative 0.0073 0.0032 0.0088
Loa Loa (eye worm) TOPoisomerase family member 0.034 0.0184 0.0184
Echinococcus granulosus FERM domain containing protein 3 0.0206 0.0108 0.011
Trypanosoma brucei heat shock protein 90, putative 0.034 0.0184 0.0527
Onchocerca volvulus 0.0206 0.0108 0.4999
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Loa Loa (eye worm) neurofibromin 2 isoform 8 0.0206 0.0108 0.0108
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Trichomonas vaginalis TK family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0073 0.0032 0.0033
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.0032 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0017 0.0017
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Echinococcus multilocularis tyrosine kinase 0.0073 0.0032 0.0033
Echinococcus granulosus merlin:moesin:ezrin:radixin 0.0206 0.0108 0.011
Schistosoma mansoni pyruvate dehydrogenase 0.6113 0.3464 0.3505
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Echinococcus multilocularis unc 112 protein 0.0206 0.0108 0.011
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0151 0.0077 0.0077
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Brugia malayi hypothetical protein 0.0073 0.0032 0.0032
Mycobacterium tuberculosis Two component sensor kinase MprB 0.034 0.0184 1
Schistosoma mansoni tyrosine kinase 1.7413 0.9883 1
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.034 0.0184 1
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Echinococcus multilocularis tyrosine protein kinase 0.0073 0.0032 0.0033
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.0094 0.4086
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0047 0.0048
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0032 0.0033
Onchocerca volvulus DNA topoisomerase 2 homolog 0.034 0.0184 1
Mycobacterium ulcerans DNA gyrase subunit B 0.034 0.0184 1
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Brugia malayi Tyrosine-protein kinase abl-1 0.0073 0.0032 0.0032
Echinococcus granulosus tyrosine protein kinase Srms 0.0073 0.0032 0.0033
Echinococcus multilocularis c src tyrosine kinase 0.0073 0.0032 0.0033
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0073 0.0032 0.0033
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0073 0.0032 0.0033
Loa Loa (eye worm) heat shock protein 90 0.034 0.0184 0.0184
Loa Loa (eye worm) TK/INSR protein kinase 0.0073 0.0032 0.0032
Echinococcus granulosus tyrosine protein kinase 0.0073 0.0032 0.0033
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.2137 0.1205 0.8617
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.034 0.0184 0.0527
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Echinococcus granulosus ephrin type A receptor 4 A 0.0073 0.0032 0.0033
Entamoeba histolytica serine/threonine kinase, putative 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.034 0.0184 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0017 0.0017
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0073 0.0032 0.0033
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.034 0.0184 1
Trypanosoma cruzi ribonuclease inhibitor, putative 0.0206 0.0108 0.0308
Brugia malayi heat shock protein 90 0.034 0.0184 0.0184
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Echinococcus multilocularis natriuretic peptide receptor 1 0.0073 0.0032 0.0033
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Echinococcus multilocularis talin 2 0.0206 0.0108 0.011
Schistosoma mansoni endoplasmin 0.034 0.0184 0.0186
Loa Loa (eye worm) TK/FAK protein kinase 1.7619 1 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0073 0.0032 0.0033
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Echinococcus granulosus talin 0.0206 0.0108 0.011
Plasmodium falciparum endoplasmin, putative 0.034 0.0184 1
Loa Loa (eye worm) TK/RYK protein kinase 0.0073 0.0032 0.0032
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0073 0.0032 0.0033
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0048 0.0049
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0073 0.0032 0.0033
Echinococcus granulosus insulin receptor 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Brugia malayi Raf kinase 0.0073 0.0032 0.0032
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0073 0.0032 0.0033
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Trypanosoma brucei heat shock protein, putative 0.034 0.0184 0.0527
Loa Loa (eye worm) hypothetical protein 0.0025 0.0005 0.0005
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0073 0.0032 0.0033
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0073 0.0032 0.0033
Echinococcus multilocularis epidermal growth factor receptor 0.0073 0.0032 0.0033
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.0032 0.0033
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Schistosoma mansoni Band 4.1-like protein 0.0206 0.0108 0.011
Loa Loa (eye worm) endoplasmin 0.034 0.0184 0.0184
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.034 0.0184 1
Trypanosoma brucei heat shock protein, putative 0.034 0.0184 0.0527
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.0032 0.0033
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Entamoeba histolytica filopodin, putative 0.0206 0.0108 0.5838
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Schistosoma mansoni pyruvate dehydrogenase 0.5773 0.3271 0.3309
Schistosoma mansoni patched 1 0.0043 0.0015 0.0015
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.561 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.437 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.029 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.977 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.954 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.858 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.526 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.259 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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