Detailed information for compound 1611715

Basic information

Technical information
  • TDR Targets ID: 1611715
  • Name: [4-[2-[(2-methylpropan-2-yl)oxycarbonylamino] -3-oxo-3-[[1-oxo-1-[[2-oxo-2-[[2-phenyl-1-(ph enylmethoxycarbonylamino)ethyl]amino]ethyl]am ino]propan-2-yl]amino]propyl]phenyl] benzoate
  • MW: 765.851 | Formula: C42H47N5O9
  • H donors: 5 H acceptors: 6 LogP: 6.1 Rotable bonds: 25
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(NC(Cc1ccccc1)NC(=O)OCc1ccccc1)CNC(=O)C(NC(=O)C(NC(=O)OC(C)(C)C)Cc1ccc(cc1)OC(=O)c1ccccc1)C
  • InChi: 1S/C42H47N5O9/c1-28(37(49)43-26-36(48)46-35(25-29-14-8-5-9-15-29)47-40(52)54-27-31-16-10-6-11-17-31)44-38(50)34(45-41(53)56-42(2,3)4)24-30-20-22-33(23-21-30)55-39(51)32-18-12-7-13-19-32/h5-23,28,34-35H,24-27H2,1-4H3,(H,43,49)(H,44,50)(H,45,53)(H,46,48)(H,47,52)
  • InChiKey: GYMQNMPRWGBGKX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-[2-(tert-butoxycarbonylamino)-3-[[1-methyl-2-oxo-2-[[2-oxo-2-[[2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]amino]ethyl]amino]ethyl]amino]-3-oxo-propyl]phenyl] benzoate
  • benzoic acid [4-[2-[(tert-butoxy-oxomethyl)amino]-3-[[1-methyl-2-oxo-2-[[2-oxo-2-[[1-[[oxo-(phenylmethoxy)methyl]amino]-2-phenylethyl]amino]ethyl]amino]ethyl]amino]-3-oxopropyl]phenyl] ester
  • benzoic acid [4-[3-[[2-[[2-[[1-(benzyloxycarbonylamino)-2-phenyl-ethyl]amino]-2-keto-ethyl]amino]-2-keto-1-methyl-ethyl]amino]-2-(tert-butoxycarbonylamino)-3-keto-propyl]phenyl] ester
  • NCI60_024437
  • 4-(11-Benzyl-2-((tert-butoxycarbonyl)amino)-5-methyl-3,6,9,13-tetraoxo-15-phenyl-14-oxa-4,7,10,12-tetraazapentadec-1-yl)phenyl benzoate
  • AIDS-145286
  • AIDS145286
  • NSC669812

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine proteinase, putative 0.0194 0.1691 0.5147
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.013 0.1099 0.1153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0243 0.2146 0.6159
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0234 0.0478
Echinococcus granulosus dnaJ subfamily B 0.0363 0.3255 0.3255
Brugia malayi cathepsin L-like precursor 0.0243 0.2146 0.2253
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0119 0.0125
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.013 0.1099 0.3048
Onchocerca volvulus 0.0037 0.0234 0.0744
Entamoeba histolytica cysteine protease, putative 0.0088 0.0714 0.1838
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0349 0.3123 0.9059
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0234 0.0245
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0349 0.3123 0.9059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0349 0.3123 0.9059
Echinococcus multilocularis transcription factor Dp 1 0.0027 0.0149 0.0149
Onchocerca volvulus Cathepsin L homolog 0.0349 0.3123 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0119 0.0125
Loa Loa (eye worm) hypothetical protein 0.0037 0.0234 0.0245
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0088 0.0714 0.1904
Entamoeba histolytica cysteine proteinase, putative 0.0349 0.3123 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0349 0.3123 1
Onchocerca volvulus 0.0111 0.0924 0.2958
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0133 0.1123 0.1178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0349 0.3123 0.9059
Loa Loa (eye worm) nuclear hormone receptor 0.0011 0.0001 0.0001
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.03 0.03
Loa Loa (eye worm) nuclear receptor NHR-67 0.0011 0.0001 0.0001
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0119 0.0119
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0119 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0088 0.0714 0.1904
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.004 0.0267 0.0577
Plasmodium falciparum serine repeat antigen 1 0.0088 0.0714 0.2285
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0119 0.0125
Schistosoma mansoni cathepsin C 0.0088 0.0714 0.0714
Brugia malayi Zinc carboxypeptidase family protein 0.0019 0.0072 0.0076
Toxoplasma gondii flagellar/basal body protein 0.0019 0.0072 0.0211
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1042 0.9528 0.9528
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0031 0.018 0.0189
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0242 0.2131 0.6113
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0088 0.0714 0.0749
Giardia lamblia Cathepsin B precursor 0.0383 0.344 1
Brugia malayi cathepsin L precursor 0.0088 0.0714 0.0749
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0119 0.0125
Loa Loa (eye worm) fibroinase 0.0349 0.3123 0.3278
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0088 0.0714 0.1904
Echinococcus multilocularis cathepsin L cysteine protease 0.0349 0.3123 0.3123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.1691 0.4805
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0111 0.0924 0.0924
Brugia malayi Cathepsin L-like precursor 0.0243 0.2146 0.2253
Toxoplasma gondii cathepsin B 0.0383 0.344 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0383 0.344 0.361
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.013 0.1099 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0119 0.0119
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.0132 0.0138
Onchocerca volvulus Cathepsin L homolog 0.0349 0.3123 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0088 0.0714 0.1904
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.0001 0.0001
Onchocerca volvulus 0.0088 0.0714 0.2283
Loa Loa (eye worm) ctsf protein 0.0349 0.3123 0.3278
Schistosoma mansoni family M14 non-peptidase homologue (M14 family) 0.0019 0.0072 0.0072
Plasmodium vivax unspecified product 0.0088 0.0714 0.2285
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0119 0.0119
Entamoeba histolytica cysteine protease, putative 0.0194 0.1691 0.5147
Echinococcus granulosus transcription factor Dp 1 0.0027 0.0149 0.0149
Loa Loa (eye worm) zinc carboxypeptidase 0.0019 0.0072 0.0076
Entamoeba histolytica cysteine proteinase 2 0.0194 0.1691 0.5147
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0194 0.1691 0.1774
Loa Loa (eye worm) hypothetical protein 0.0024 0.0119 0.0125
Entamoeba histolytica cysteine proteinase, putative 0.0349 0.3123 1
Toxoplasma gondii cathepsin CPC1 0.0088 0.0714 0.2075
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0119 0.0125
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0088 0.0714 0.0714
Onchocerca volvulus 0.0349 0.3123 1
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.1691 0.1774
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.003 0.0171 0.0171
Schistosoma mansoni cpg binding protein 0.0027 0.0145 0.0145
Schistosoma mansoni coup transcription factor 0.0024 0.0119 0.0119
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0234 0.0478
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0076
Trypanosoma cruzi cysteine peptidase, putative 0.0349 0.3123 0.3278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0349 0.3123 0.9079
Echinococcus granulosus cathepsin b 0.1042 0.9528 0.9528
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0088 0.0714 0.2285
Trypanosoma cruzi cysteine peptidase, putative 0.0349 0.3123 0.3278
Giardia lamblia Cysteine protease 0.0088 0.0714 0.1904
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.1691 0.1774
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.004 0.0267 0.0775
Entamoeba histolytica cysteine protease, putative 0.0194 0.1691 0.5147
Brugia malayi Zinc carboxypeptidase family protein 0.0019 0.0072 0.0076
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0234 0.0234
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.013 0.1099 0.1153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0349 0.3123 0.9079
Brugia malayi hypothetical protein 0.0013 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0349 0.3123 0.9059
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0234 0.0679
Echinococcus multilocularis lysine specific demethylase 5A 0.0042 0.0286 0.0286
Echinococcus multilocularis dnaJ subfamily B 0.0363 0.3255 0.3255
Plasmodium vivax unspecified product 0.0194 0.1691 0.5413
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0088 0.0714 0.2285
Toxoplasma gondii histone lysine methyltransferase SET1 0.0048 0.0343 0.0996
Schistosoma mansoni cpg binding protein 0.0026 0.0132 0.0132
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0047 0.0334 0.0351
Onchocerca volvulus 0.0037 0.0234 0.0744
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0234 0.0478
Giardia lamblia Cathepsin B precursor 0.0088 0.0714 0.1904
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0019 0.0072 0.0211
Plasmodium vivax serine-repeat antigen (SERA) 0.0088 0.0714 0.2285
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.0001 0.0001
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1042 0.9528 0.9528
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0047 0.0334 0.0351
Onchocerca volvulus 0.0349 0.3123 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0234 0.0234
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0088 0.0714 0.1838
Echinococcus multilocularis Zinc carboxypeptidase family protein 0.0019 0.0072 0.0072
Brugia malayi Zinc carboxypeptidase family protein 0.0019 0.0072 0.0076
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0088 0.0714 0.0714
Loa Loa (eye worm) hypothetical protein 0.0037 0.0234 0.0245
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0001 0.0001
Trypanosoma cruzi Carboxypeptidase-like protein 0.0019 0.0072 0.0076
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.013 0.1099 0.3048
Brugia malayi steroid hormone receptor 0.0024 0.0119 0.0125
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0088 0.0714 0.2285
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0242 0.2131 0.6113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0349 0.3123 0.9059
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0349 0.3123 0.9059
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0031 0.018 0.0189
Onchocerca volvulus 0.0037 0.0234 0.0744
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.013 0.1099 0.3048
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.004 0.0267 0.0577
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0088 0.0714 0.0714
Onchocerca volvulus Cathepsin F homolog 0.0349 0.3123 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0088 0.0714 0.1904
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0119 0.0377
Entamoeba histolytica protein tyrosine phosphatase, putative 0.013 0.1099 0.3143
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0088 0.0714 0.0749
Brugia malayi Zinc carboxypeptidase family protein 0.0019 0.0072 0.0076
Brugia malayi hypothetical protein 0.0125 0.1051 0.1104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0088 0.0714 0.1904
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0349 0.3123 0.9059
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.013 0.1099 0.3048
Onchocerca volvulus 0.0349 0.3123 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0349 0.3123 0.3278
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0076
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0349 0.3123 0.9059
Trypanosoma brucei Carboxypeptidase-like protein 0.0019 0.0072 0.0211
Entamoeba histolytica cysteine protease, putative 0.0088 0.0714 0.1838
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0119 0.0125
Brugia malayi Papain family cysteine protease containing protein 0.0349 0.3123 0.3278
Echinococcus multilocularis cathepsin L 0.0194 0.1691 0.1691
Brugia malayi fibroinase precursor 0.0088 0.0714 0.0749
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0031 0.018 0.018
Trypanosoma cruzi cysteine peptidase, putative 0.0349 0.3123 0.3278
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0088 0.0714 0.1904
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0013 0.0014 0.0014
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0111 0.0924 0.2958
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0047 0.0334 0.0552
Leishmania major cathepsin L-like protease 0.0349 0.3123 0.9079
Entamoeba histolytica cysteine protease, putative 0.0088 0.0714 0.1838
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0047 0.0334 0.0971
Leishmania major cathepsin L-like protease 0.0349 0.3123 0.9079
Loa Loa (eye worm) hypothetical protein 0.0106 0.0873 0.0916
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0119 0.0125
Brugia malayi Cathepsin L-like precursor 0.0349 0.3123 0.3278
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0119 0.0119
Brugia malayi nuclear receptor RXR 0.0013 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0349 0.3123 0.9059
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0119 0.0125
Trypanosoma cruzi cysteine proteinase, putative 0.0194 0.1691 0.1774
Echinococcus multilocularis cytosolic carboxypeptidase protein 5 0.0019 0.0072 0.0072
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0088 0.0714 0.1904
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.013 0.1099 0.3048
Loa Loa (eye worm) beta-lactamase 0.0037 0.0234 0.0245
Loa Loa (eye worm) cysteine protease 0.0349 0.3123 0.3278
Echinococcus multilocularis cysteine protease 0.0349 0.3123 0.3123
Loa Loa (eye worm) hypothetical protein 0.0024 0.0119 0.0125
Schistosoma mansoni zinc finger protein 0.0011 0.0001 0.0001
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0088 0.0714 0.0714
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0119 0.0119
Plasmodium falciparum cysteine proteinase falcipain 1 0.0194 0.1691 0.5413
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0047 0.0334 0.0351
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0119 0.0119
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0119 0.0125
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0088 0.0714 0.1904
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0119 0.0119
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0234 0.0245
Echinococcus granulosus cysteine protease 0.0194 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0243 0.2146 0.2253
Giardia lamblia Fructose-bisphosphate aldolase 0.0242 0.2131 0.6113
Giardia lamblia Cathepsin B precursor 0.0088 0.0714 0.1904
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.018 0.018
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0013 0.0013
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0119 0.0119
Trypanosoma cruzi cysteine peptidase, putative 0.0194 0.1691 0.1774
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.0001 0.0001
Trichomonas vaginalis esterase, putative 0.0037 0.0234 0.0478
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0001 0.0001
Schistosoma mansoni nuclear receptor nhr-48 0.0011 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0349 0.3123 0.9079
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0349 0.3123 0.9059
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0234 0.0234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0349 0.3123 0.9079
Schistosoma mansoni transcription factor LCR-F1 0.003 0.0171 0.0171
Schistosoma mansoni cathepsin F (C01 family) 0.0349 0.3123 0.3123
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0019 0.0072 0.0076
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0019 0.0072 0.0211
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.013 0.1099 0.3048
Toxoplasma gondii preprocathepsin c precursor, putative 0.0088 0.0714 0.2075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.018 0.018
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0119 0.0119
Brugia malayi nuclear receptor NHR-88 0.0011 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0242 0.2131 0.6113
Echinococcus granulosus muscleblind protein 0.0133 0.1123 0.1123
Loa Loa (eye worm) hypothetical protein 0.0088 0.0714 0.0749
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0088 0.0714 0.1904
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0349 0.3123 0.9059
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0106 0.0873 0.0916
Brugia malayi tailless protein 0.0011 0.0001 0.0001
Brugia malayi Papain family cysteine protease containing protein 0.0088 0.0714 0.0749
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0001 0.0001
Toxoplasma gondii cathepsin CPL 0.0349 0.3123 0.9079
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0119 0.0125
Toxoplasma gondii ABC1 family protein 0.0037 0.0234 0.0679
Brugia malayi Cathepsin L-like precursor 0.0243 0.2146 0.2253
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0119 0.0125
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0019 0.0072 0.0211
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0349 0.3123 0.9059
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0118 0.0988 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0349 0.3123 0.9079
Leishmania major cathepsin L-like protease 0.0349 0.3123 0.9079
Echinococcus multilocularis cathepsin b 0.1042 0.9528 0.9528
Schistosoma mansoni cpg binding protein 0.0027 0.0145 0.0145
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1042 0.9528 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0076
Brugia malayi beta-lactamase 0.0037 0.0234 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0349 0.3123 0.9059
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0088 0.0714 0.1904
Loa Loa (eye worm) hypothetical protein 0.0024 0.0119 0.0125
Onchocerca volvulus 0.0125 0.1051 0.3364
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0349 0.3123 0.9079
Onchocerca volvulus 0.0349 0.3123 1
Echinococcus granulosus cathepsin l1 0.0349 0.3123 0.3123
Leishmania major cathepsin L-like protease 0.0349 0.3123 0.9079
Plasmodium vivax vivapain-3 0.0194 0.1691 0.5413
Giardia lamblia Cathepsin L-like protease 0.0088 0.0714 0.1904
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0349 0.3123 0.9059
Echinococcus multilocularis cpg binding protein 0.0027 0.0145 0.0145
Onchocerca volvulus Cytosolic carboxypeptidase 1 homolog 0.0019 0.0072 0.0229
Entamoeba histolytica cysteine protease, putative 0.0194 0.1691 0.5147
Loa Loa (eye worm) hypothetical protein 0.0125 0.1051 0.1104
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0383 0.344 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0119 0.0125
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0267 0.028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0349 0.3123 0.9059
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0243 0.2146 0.2253
Giardia lamblia Hypothetical protein 0.0088 0.0714 0.1904
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0088 0.0714 0.2285
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0242 0.2131 0.6113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0349 0.3123 0.9079
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1042 0.9528 0.9528
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0019 0.0072 0.0211
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0119 0.0119
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0042 0.0286 0.0286
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0019 0.0072 0.0211
Loa Loa (eye worm) hypothetical protein 0.0088 0.0714 0.0749
Echinococcus granulosus Zinc carboxypeptidase family protein 0.0019 0.0072 0.0072
Schistosoma mansoni cathepsin F (C01 family) 0.0349 0.3123 0.3123
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.0001 0.0001
Entamoeba histolytica cysteine protease, putative 0.0088 0.0714 0.1838
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0019 0.0072 0.0076
Giardia lamblia Cathepsin B precursor 0.0383 0.344 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0873 0.0916
Loa Loa (eye worm) DR-78 0.0011 0.0001 0.0001
Echinococcus multilocularis 0.0019 0.0072 0.0072
Entamoeba histolytica cysteine protease, putative 0.0194 0.1691 0.5147
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0019 0.0072 0.0211
Entamoeba histolytica cysteine protease, putative 0.0349 0.3123 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0194 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0076
Schistosoma mansoni peptidase 0.0019 0.0072 0.0072
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0118 0.0988 0.4145
Leishmania major cathepsin L-like protease 0.0349 0.3123 0.9079
Brugia malayi cathepsin Z-like cysteine proteinase 0.0088 0.0714 0.0749
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0119 0.0125
Leishmania major cathepsin L-like protease 0.0349 0.3123 0.9079
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0024 0.0119 0.0125
Schistosoma mansoni cathepsin S (C01 family) 0.0088 0.0714 0.0714
Brugia malayi hypothetical protein 0.0013 0.0014 0.0014
Echinococcus granulosus cathepsin l cysteine peptidase 0.0349 0.3123 0.3123
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0383 0.344 0.344
Entamoeba histolytica protein tyrosine phosphatase, putative 0.013 0.1099 0.3143
Schistosoma mansoni cathepsin s 0.0106 0.0873 0.0873
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.1691 0.4914
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.018 0.018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0242 0.2131 0.6113
Brugia malayi cathepsin F-like cysteine proteinase 0.0088 0.0714 0.0749
Entamoeba histolytica cysteine protease, putative 0.0194 0.1691 0.5147
Echinococcus granulosus cytosolic carboxypeptidase protein 5 0.0019 0.0072 0.0072
Brugia malayi Zinc carboxypeptidase family protein 0.0019 0.0072 0.0076
Echinococcus multilocularis cathepsin L cysteine protease 0.0349 0.3123 0.3123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0349 0.3123 0.9059
Echinococcus granulosus cytosolic carboxypeptidase 1 0.0019 0.0072 0.0072
Leishmania major cathepsin L-like protease 0.0349 0.3123 0.9079
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0047 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Brugia malayi ecdysteroid receptor 0.0024 0.0119 0.0125
Plasmodium vivax serine-repeat antigen (SERA) 0.0088 0.0714 0.2285
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0119 0.0119
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.003 0.0171 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0119 0.0125
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0088 0.0714 0.0714
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0119 0.0377
Onchocerca volvulus 0.0024 0.0119 0.0377
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0014
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0047 0.0334 0.0334
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0088 0.0714 0.0714
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0011 0.0001 0.0001
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0088 0.0714 0.2285
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0014 0.0014
Giardia lamblia Cathepsin L precursor 0.0088 0.0714 0.1904
Loa Loa (eye worm) hypothetical protein 0.0037 0.0234 0.0245
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0014
Plasmodium falciparum serine repeat antigen 4 0.0088 0.0714 0.2285
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0014 0.0014
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0088 0.0714 0.1838
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0072 0.0232
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0119 0.0119
Schistosoma mansoni cathepsin B (C01 family) 0.0088 0.0714 0.0714
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0014
Giardia lamblia Cathepsin L precursor 0.0088 0.0714 0.1904
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0076
Plasmodium falciparum serine repeat antigen 2 0.0088 0.0714 0.2285
Entamoeba histolytica cysteine protease, putative 0.0194 0.1691 0.5147
Brugia malayi cathepsin F-like cysteine proteinase 0.0106 0.0873 0.0916
Brugia malayi Papain family cysteine protease containing protein 0.0088 0.0714 0.0749
Trypanosoma brucei cysteine peptidase C (CPC) 0.0383 0.344 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0076
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0001 0.0001
Echinococcus multilocularis muscleblind protein 0.0133 0.1123 0.1123
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0133 0.1123 0.1178
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0019 0.0072 0.0072
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0001 0.0001
Entamoeba histolytica cysteine proteinase 1, putative 0.0194 0.1691 0.5147
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0031 0.018 0.018
Onchocerca volvulus 0.0026 0.0132 0.0418
Brugia malayi cathepsin B-like cysteine proteinase 0.1042 0.9528 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0234 0.0245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0349 0.3123 0.9079
Brugia malayi Cathepsin L-like precursor 0.0349 0.3123 0.3278
Schistosoma mansoni hypothetical protein 0.0363 0.3255 0.3255
Onchocerca volvulus 0.0349 0.3123 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0013 0.0013
Giardia lamblia Cathepsin L precursor 0.0088 0.0714 0.1904
Loa Loa (eye worm) hypothetical protein 0.0024 0.0119 0.0125
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0088 0.0714 0.0714
Brugia malayi Carboxypeptidase A2 precursor 0.0019 0.0072 0.0076
Brugia malayi nuclear receptor RXR 0.0011 0.0001 0.0001
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.0001 0.0001
Brugia malayi Cathepsin L-like precursor 0.0106 0.0873 0.0916
Brugia malayi Muscleblind-like protein 0.0133 0.1123 0.1178
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0242 0.2131 0.6639
Giardia lamblia Cathepsin B precursor 0.0088 0.0714 0.1904
Giardia lamblia Cysteine protease 0.0088 0.0714 0.1904
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0119 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0119 0.0125
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0119 0.0119
Trypanosoma cruzi cysteine peptidase, putative 0.0349 0.3123 0.3278
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0088 0.0714 0.0749
Entamoeba histolytica cysteine protease, putative 0.0194 0.1691 0.5147
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma cruzi cysteine protease, putative 0.0194 0.1691 0.1774
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0119 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0714 0.1904
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0349 0.3123 0.9079
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0088 0.0714 0.2285
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0076
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0119 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0349 0.3123 0.9059
Onchocerca volvulus 0.0243 0.2146 0.6871
Entamoeba histolytica cysteine protease, putative 0.0194 0.1691 0.5147
Plasmodium falciparum serine repeat antigen 9 0.0088 0.0714 0.2285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0119 0.0125
Loa Loa (eye worm) hypothetical protein 0.0024 0.0119 0.0125
Loa Loa (eye worm) hypothetical protein 0.0243 0.2146 0.2253
Plasmodium vivax unspecified product 0.0106 0.0873 0.2794
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0119 0.0125
Treponema pallidum fructose-bisphosphate aldolase 0.0242 0.2131 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0194 0.1691 0.5147
Toxoplasma gondii zinc carboxypeptidase, putative 0.0019 0.0072 0.0211
Echinococcus granulosus cathepsin L cysteine protease 0.0194 0.1691 0.1691
Plasmodium vivax vivapain-1 0.0194 0.1691 0.5413
Brugia malayi cathepsin Z-like cysteine proteinase 0.0088 0.0714 0.0749
Echinococcus granulosus cpg binding protein 0.0027 0.0145 0.0145
Onchocerca volvulus 0.013 0.1099 0.3516
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0088 0.0714 0.1904
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0119 0.0119
Schistosoma mansoni jumonji domain containing protein 0.0042 0.0286 0.0286
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0234 0.0234
Onchocerca volvulus 0.0019 0.0072 0.0229
Trypanosoma cruzi cysteine proteinase, putative 0.0194 0.1691 0.1774
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0242 0.2131 0.6639
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0267 0.028
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0019 0.0072 0.0211
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0234 0.0245
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0349 0.3123 0.9059
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0234 0.0478
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0076
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0047 0.0334 0.0334
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0013 0.0014 0.0014
Plasmodium falciparum serine repeat antigen 6 0.0088 0.0714 0.2285
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0047 0.0334 0.0351
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0001 0.0001
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0349 0.3123 0.3278
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0013 0.0014 0.0014
Onchocerca volvulus 0.0349 0.3123 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0119 0.0125
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0349 0.3123 0.3123
Echinococcus granulosus cathepsin b 0.1042 0.9528 0.9528
Entamoeba histolytica hypothetical protein 0.0088 0.0714 0.1838
Loa Loa (eye worm) hypothetical protein 0.0243 0.2146 0.2253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0088 0.0714 0.1904
Onchocerca volvulus 0.0111 0.0924 0.2958
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0088 0.0714 0.2285
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0383 0.344 1
Brugia malayi Papain family cysteine protease containing protein 0.0088 0.0714 0.0749
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0031 0.018 0.018
Brugia malayi cathepsin L-like cysteine proteinase 0.0088 0.0714 0.0749
Onchocerca volvulus 0.0019 0.0072 0.0229
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0088 0.0714 0.2285
Schistosoma mansoni peptidase 0.0019 0.0072 0.0072
Brugia malayi hypothetical protein 0.003 0.0171 0.018
Brugia malayi nuclear hormone receptor 0.0011 0.0001 0.0001
Entamoeba histolytica cysteine protease, putative 0.0194 0.1691 0.5147
Plasmodium falciparum serine repeat antigen 3 0.0088 0.0714 0.2285
Brugia malayi ecdysone receptor 0.0011 0.0001 0.0001
Brugia malayi Cathepsin L-like precursor 0.0349 0.3123 0.3278
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0119 0.0125
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0076
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0011 0.0001 0.0001
Giardia lamblia Encystation-specific protease 0.0088 0.0714 0.1904
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0088 0.0714 0.0714
Plasmodium falciparum serine repeat antigen 8 0.0088 0.0714 0.2285
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0119 0.0125
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.03 0.03
Onchocerca volvulus Cathepsin L homolog 0.0088 0.0714 0.2283
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0234 0.0748
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.013 0.1099 0.3048
Loa Loa (eye worm) zinc carboxypeptidase 0.0019 0.0072 0.0076
Echinococcus multilocularis cysteine protease 0.0349 0.3123 0.3123
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0001 0.0001
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0119 0.0377
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0088 0.0714 0.0749
Brugia malayi Cathepsin L-like precursor 0.0349 0.3123 0.3278
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0088 0.0714 0.1904
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0234 0.0245
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0088 0.0714 0.1904
Loa Loa (eye worm) hypothetical protein 0.0349 0.3123 0.3278
Onchocerca volvulus 0.0349 0.3123 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0349 0.3123 0.9059
Brugia malayi conserved hypotetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0349 0.3123 0.9059
Leishmania major cathepsin L-like protease 0.0349 0.3123 0.9079
Echinococcus multilocularis muscleblind protein 1 0.0133 0.1123 0.1123
Giardia lamblia Cathepsin L-like protease 0.0088 0.0714 0.1904
Brugia malayi Cathepsin L-like precursor 0.0349 0.3123 0.3278
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0088 0.0714 0.2285
Giardia lamblia Cathepsin B precursor 0.0088 0.0714 0.1904
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0119 0.0119
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0349 0.3123 0.9059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0076
Brugia malayi Zinc carboxypeptidase family protein 0.0019 0.0072 0.0076
Onchocerca volvulus 0.0111 0.0924 0.2958
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0714 0.1904
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0054 0.0396 0.0396
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0088 0.0714 0.1904
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0234 0.0478
Entamoeba histolytica cysteine proteinase, putative 0.0243 0.2146 0.6691
Loa Loa (eye worm) zinc carboxypeptidase 0.0019 0.0072 0.0076
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0119 0.0119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0349 0.3123 0.9079
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0119 0.0125
Onchocerca volvulus Carboxypeptidase D homolog 0.0019 0.0072 0.0229
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.0001 0.0001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0119 0.0119
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.072 0.6554 0.6554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0349 0.3123 0.9059
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0031 0.018 0.018
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0111 0.0924 0.0924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0243 0.2146 0.6159
Schistosoma mansoni cathepsin F (C01 family) 0.0243 0.2146 0.2146
Giardia lamblia Cysteine protease 0.0088 0.0714 0.1904
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.03 0.0314
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0088 0.0714 0.1904
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0013 0.0014 0.0014
Trypanosoma cruzi cysteine peptidase, putative 0.0106 0.0873 0.0916
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0111 0.0924 0.0924
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0349 0.3123 0.9079
Entamoeba histolytica cysteine protease, putative 0.0194 0.1691 0.5147
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0242 0.2131 0.6113
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0088 0.0714 0.1904
Plasmodium falciparum serine repeat antigen 7 0.0088 0.0714 0.2285
Entamoeba histolytica cysteine protease, putative 0.0088 0.0714 0.1838
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.2053 1
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0037 0.0234 0.0245
Entamoeba histolytica cysteine proteinase, putative 0.0194 0.1691 0.5147
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.003 0.0171 0.0171
Echinococcus multilocularis cathepsin L 0.0088 0.0714 0.0714
Schistosoma mansoni carboxypeptidase N (M14 family) 0.0019 0.0072 0.0072
Brugia malayi nuclear hormone receptor 0.0024 0.0119 0.0125
Plasmodium falciparum serine repeat antigen 5 0.0088 0.0714 0.2285
Schistosoma mansoni microtubule-associated protein tau 0.1093 1 1
Giardia lamblia Cathepsin L precursor 0.0088 0.0714 0.1904
Schistosoma mansoni nuclear receptor 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Onchocerca volvulus 0.0111 0.0924 0.2958
Echinococcus multilocularis microtubule associated protein 2 0.1093 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0106 0.0873 0.0916
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0119 0.0119
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0088 0.0714 0.2285
Plasmodium vivax vivapain-2 0.0349 0.3123 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0243 0.2146 0.2253
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0119 0.0119
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.0001 0.0001
Loa Loa (eye worm) cathepsin B 0.0383 0.344 0.361
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0242 0.2131 0.6113
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0092 0.0748 0.0785
Entamoeba histolytica cysteine protease, putative 0.0194 0.1691 0.5147
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0042 0.0286 0.0286
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0349 0.3123 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.03 0.03
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0118 0.0988 0.8717
Brugia malayi CXXC zinc finger family protein 0.0026 0.0132 0.0138
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14 0.0019 0.0072 0.0076
Giardia lamblia Cathepsin L precursor 0.0088 0.0714 0.1904
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0349 0.3123 0.3123
Giardia lamblia Cysteine protease 0.0088 0.0714 0.1904
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0194 0.1691 0.1691
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0088 0.0714 0.1904
Giardia lamblia Cathepsin B precursor 0.0383 0.344 1
Brugia malayi Zinc carboxypeptidase family protein 0.0019 0.0072 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0119 0.0125
Giardia lamblia Hypothetical protein 0.0088 0.0714 0.1904
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0194 0.1691 0.1691
Trypanosoma cruzi zinc carboxypeptidase, putative 0.0019 0.0072 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0088 0.0714 0.1904
Brugia malayi Cathepsin L-like precursor 0.0349 0.3123 0.3278
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0119 0.0119
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.009 0.0728 0.2718
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0088 0.0714 0.2285
Schistosoma mansoni metallocarboxypeptidase D peptidase unit 2 (M14 family) 0.0019 0.0072 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0088 0.0714 0.1904
Loa Loa (eye worm) hypothetical protein 0.0088 0.0714 0.0749
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0119 0.0119
Plasmodium falciparum cysteine proteinase falcipain 3 0.0349 0.3123 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0119 0.0119
Brugia malayi Zinc carboxypeptidase family protein 0.0019 0.0072 0.0076
Entamoeba histolytica cysteine proteinase, putative 0.0194 0.1691 0.5147
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0001 0.0001
Echinococcus granulosus cathepsin L 0.0194 0.1691 0.1691
Trypanosoma cruzi major cysteine proteinase, putative 0.0088 0.0714 0.0749
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0088 0.0714 0.2285
Schistosoma mansoni nuclear receptor 0.0011 0.0001 0.0001
Echinococcus multilocularis cathepsin b 0.1042 0.9528 0.9528
Brugia malayi beta-lactamase family protein 0.0037 0.0234 0.0245
Loa Loa (eye worm) zinc carboxypeptidase 0.0019 0.0072 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.1691 0.4805
Trypanosoma cruzi cruzipain precursor, putative 0.0106 0.0873 0.0916
Entamoeba histolytica cysteine protease, putative 0.0194 0.1691 0.5147
Trypanosoma cruzi major cysteine proteinase, putative 0.0088 0.0714 0.0749
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.1691 0.4914
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0088 0.0714 0.0714
Entamoeba histolytica cysteine protease, putative 0.0088 0.0714 0.1838
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0242 0.2131 0.6113
Leishmania major hypothetical protein, conserved 0.004 0.0267 0.0775
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0349 0.3123 0.9059
Brugia malayi nuclear receptor NHR-67 0.0011 0.0001 0.0001
Giardia lamblia Cathepsin L precursor 0.0088 0.0714 0.1904
Trypanosoma cruzi cruzipain precursor, putative 0.0349 0.3123 0.3278
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Echinococcus granulosus cathepsin L 0.0088 0.0714 0.0714
Loa Loa (eye worm) hypothetical protein 0.1042 0.9528 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0873 0.0916
Echinococcus granulosus cathepsin l1 0.0243 0.2146 0.2146
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni peptidase 0.0019 0.0072 0.0072
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0088 0.0714 0.2285
Loa Loa (eye worm) hypothetical protein 0.0024 0.0119 0.0125
Entamoeba histolytica cysteine protease, putative 0.0194 0.1691 0.5147
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.0001 0.0001
Leishmania major cysteine peptidase A (CPA) 0.0349 0.3123 0.9079
Schistosoma mansoni protease m14 carboxypeptidase 0.0019 0.0072 0.0072
Leishmania major hypothetical protein, conserved 0.0037 0.0234 0.0679
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0047 0.0334 0.0971
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1042 0.9528 0.9528
Loa Loa (eye worm) hypothetical protein 0.0088 0.0714 0.0749
Echinococcus granulosus cathepsin L cysteine proteinase 0.0349 0.3123 0.3123
Loa Loa (eye worm) hypothetical protein 0.0037 0.0234 0.0245
Toxoplasma gondii cathepsin CPC2 0.0088 0.0714 0.2075
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.0001 0.0001
Brugia malayi jmjC domain containing protein 0.0044 0.03 0.0314
Loa Loa (eye worm) hypothetical protein 0.0088 0.0714 0.0749
Giardia lamblia Cathepsin B precursor 0.0088 0.0714 0.1904
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0119 0.0125
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0349 0.3123 0.9059
Brugia malayi nuclear receptor NHR-88 0.0024 0.0119 0.0125
Brugia malayi jmjC domain containing protein 0.0042 0.0286 0.03
Plasmodium vivax vivapain-2 0.0349 0.3123 1
Brugia malayi beta-lactamase family protein 0.0037 0.0234 0.0245
Loa Loa (eye worm) hypothetical protein 0.0088 0.0714 0.0749

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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