Detailed information for compound 1612126

Basic information

Technical information
  • TDR Targets ID: 1612126
  • Name: [4-[(E)-[(4-hydroxybenzoyl)hydrazinylidene]me thyl]phenyl] 2-chlorobenzoate
  • MW: 394.808 | Formula: C21H15ClN2O4
  • H donors: 2 H acceptors: 3 LogP: 4.51 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)C(=O)N/N=C/c1ccc(cc1)OC(=O)c1ccccc1Cl
  • InChi: 1S/C21H15ClN2O4/c22-19-4-2-1-3-18(19)21(27)28-17-11-5-14(6-12-17)13-23-24-20(26)15-7-9-16(25)10-8-15/h1-13,25H,(H,24,26)/b23-13+
  • InChiKey: WHROHZUVTXKXLT-YDZHTSKRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-[[(4-hydroxybenzoyl)hydrazinylidene]methyl]phenyl] 2-chlorobenzoate
  • [4-[[(4-hydroxybenzoyl)hydrazono]methyl]phenyl] 2-chlorobenzoate
  • [4-[(E)-[(4-hydroxybenzoyl)hydrazono]methyl]phenyl] 2-chlorobenzoate
  • 2-chlorobenzoic acid [4-[(E)-[[(4-hydroxyphenyl)-oxomethyl]hydrazono]methyl]phenyl] ester
  • 2-chlorobenzoic acid [4-[[[(4-hydroxyphenyl)-oxomethyl]hydrazono]methyl]phenyl] ester
  • 2-chlorobenzoic acid [4-[(E)-[(4-hydroxybenzoyl)hydrazono]methyl]phenyl] ester
  • 2-chlorobenzoic acid [4-[[(4-hydroxybenzoyl)hydrazono]methyl]phenyl] ester
  • [4-[[(4-hydroxyphenyl)carbonylhydrazinylidene]methyl]phenyl] 2-chlorobenzoate
  • [4-[(E)-[(4-hydroxyphenyl)carbonylhydrazinylidene]methyl]phenyl] 2-chlorobenzoate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens neurotensin receptor 1 (high affinity) Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0004 0.005 0.0057
Echinococcus granulosus SWI:SNF matrix associated 0.0118 0.4068 0.6489
Schistosoma mansoni zinc finger protein 0.0042 0.1382 0.2273
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0004 0.005 0.008
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0118 0.4068 0.6489
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0042 0.1382 0.3314
Brugia malayi Bromodomain containing protein 0.0004 0.005 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1849 0.3042
Loa Loa (eye worm) hypothetical protein 0.0004 0.005 0.0057
Plasmodium falciparum bromodomain protein 1 0.0004 0.005 0.00000013272
Echinococcus multilocularis SWI:SNF matrix associated 0.0118 0.4068 0.6489
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.1565 1
Brugia malayi Bromodomain containing protein 0.0004 0.005 0.0057
Schistosoma mansoni hypothetical protein 0.0004 0.005 0.0082
Echinococcus multilocularis Bromodomain containing protein 0.0004 0.005 0.008
Echinococcus multilocularis CREB binding protein 0.0004 0.005 0.008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.1172 0.1869
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0042 0.1382 1
Schistosoma mansoni hypothetical protein 0.0118 0.4068 0.6691
Loa Loa (eye worm) hypothetical protein 0.0042 0.1382 0.1575
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.4068 0.4038
Leishmania major hypothetical protein, conserved 0.0042 0.1382 1
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0042 0.1382 0.2204
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1849 0.295
Echinococcus multilocularis 0.0004 0.005 0.008
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.1716 0.4147
Onchocerca volvulus 0.0042 0.1382 0.1382
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1849 0.295
Onchocerca volvulus 0.0004 0.005 0.005
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0118 0.4068 0.6489
Loa Loa (eye worm) hypothetical protein 0.0004 0.005 0.0057
Schistosoma mansoni hypothetical protein 0.0004 0.005 0.0082
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.1172 0.1869
Echinococcus multilocularis zinc finger protein Ran binding 0.0042 0.1382 0.2204
Brugia malayi ATPase, AAA family protein 0.0004 0.005 0.0057
Onchocerca volvulus 0.0042 0.1382 0.1382
Schistosoma mansoni hypothetical protein 0.0118 0.4068 0.6691
Brugia malayi Bromodomain containing protein 0.0004 0.005 0.0057
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.1716 0.2738
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0118 0.4068 1
Echinococcus granulosus PH interacting protein 0.0004 0.005 0.008
Echinococcus granulosus CREB binding protein 0.0004 0.005 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.1382 1
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0042 0.1382 0.3314
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.1382 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.005 0.0057
Schistosoma mansoni hypothetical protein 0.0042 0.1382 0.2273
Echinococcus granulosus peregrin 0.0004 0.005 0.008
Onchocerca volvulus 0.0004 0.005 0.005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1849 0.295
Schistosoma mansoni zinc finger protein 0.0004 0.005 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.1382 1
Echinococcus granulosus polybromo 1 0.0004 0.005 0.008
Schistosoma mansoni fusion 0.0042 0.1382 0.2273
Schistosoma mansoni bromodomain containing protein 0.0004 0.005 0.0082
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.1565 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.1172 0.1927
Brugia malayi Pre-SET motif family protein 0.0251 0.8774 1
Brugia malayi Pre-SET motif family protein 0.0036 0.1172 0.1335
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0042 0.1382 0.1575
Loa Loa (eye worm) hypothetical protein 0.0004 0.005 0.0057
Schistosoma mansoni bromodomain containing protein 0.0004 0.005 0.0082
Leishmania major hypothetical protein, conserved 0.0042 0.1382 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.1382 0.1575
Brugia malayi Bromodomain containing protein 0.0004 0.005 0.0057
Schistosoma mansoni hypothetical protein 0.0004 0.005 0.0082
Onchocerca volvulus 0.0004 0.005 0.005
Echinococcus granulosus Bromodomain containing protein 0.0004 0.005 0.008
Onchocerca volvulus 0.0042 0.1382 0.1382
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.1125 0.1794
Chlamydia trachomatis SWIB complex protein 0.0118 0.4068 0.5
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.6079 0.6929
Schistosoma mansoni transcription initiation factor tfiid 0.0004 0.005 0.0082
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0042 0.1382 1
Brugia malayi BRM protein 0.0004 0.005 0.0057
Schistosoma mansoni hypothetical protein 0.0118 0.4068 0.6691
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0118 0.4068 1
Leishmania major hypothetical protein, conserved 0.0042 0.1382 1
Loa Loa (eye worm) bromodomain containing protein 0.0004 0.005 0.0057
Brugia malayi YY1-associated factor 2 0.0042 0.1382 0.1575
Loa Loa (eye worm) hypothetical protein 0.0004 0.005 0.0057
Loa Loa (eye worm) acetyltransferase 0.0175 0.6079 0.6929
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0118 0.4068 1
Trypanosoma cruzi WLM domain containing protein, putative 0.0042 0.1382 1
Trypanosoma cruzi WLM domain containing protein, putative 0.0042 0.1382 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.6079 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1849 0.295
Brugia malayi Bromodomain containing protein 0.0004 0.005 0.0057
Brugia malayi Bromodomain containing protein 0.0004 0.005 0.0057
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.1172 0.2792
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.1565 0.377
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0042 0.1382 0.2204
Onchocerca volvulus Brd8 homolog 0.0004 0.005 0.005
Echinococcus multilocularis polybromo 1 0.0004 0.005 0.008
Echinococcus multilocularis PH interacting protein 0.0004 0.005 0.008
Plasmodium vivax hypothetical protein, conserved 0.0004 0.005 0.00000013272
Echinococcus granulosus muscleblind protein 0.018 0.6269 1
Loa Loa (eye worm) bromodomain containing protein 0.0004 0.005 0.0057
Loa Loa (eye worm) BRM protein 0.0004 0.005 0.0057
Loa Loa (eye worm) hypothetical protein 0.018 0.6269 0.7145
Echinococcus granulosus zinc finger protein 0.0004 0.005 0.008
Echinococcus multilocularis protein kinase C binding protein 1 0.0004 0.005 0.008
Loa Loa (eye worm) hypothetical protein 0.0004 0.005 0.0057
Brugia malayi Bromodomain containing protein 0.0004 0.005 0.0057
Toxoplasma gondii bromodomain-containing protein 0.0004 0.005 0.00000013272
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0042 0.1382 0.1575
Schistosoma mansoni CREB-binding protein 2 0.0004 0.005 0.0082
Echinococcus granulosus CREB binding protein 0.0004 0.005 0.008
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0004 0.005 0.008
Toxoplasma gondii ran binding protein 0.0042 0.1382 0.3314
Brugia malayi Muscleblind-like protein 0.018 0.6269 0.7145
Loa Loa (eye worm) hypothetical protein 0.0004 0.005 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1849 0.3042
Brugia malayi polybromodomain protein 0.0004 0.005 0.0057
Echinococcus multilocularis Bromodomain containing protein 0.0004 0.005 0.008
Schistosoma mansoni helicase 0.0004 0.005 0.0082
Echinococcus multilocularis SWI:SNF matrix associated 0.0118 0.4068 0.6489
Brugia malayi polybromodomain protein 0.0004 0.005 0.0057
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0042 0.1382 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.1382 0.1575
Echinococcus granulosus bromodomain containing 2 0.0004 0.005 0.008
Onchocerca volvulus 0.0036 0.1172 0.1172
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0042 0.1382 1
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0042 0.1382 0.1382
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0042 0.1382 0.1575
Trichomonas vaginalis set domain proteins, putative 0.0286 1 1
Loa Loa (eye worm) CBP-B 0.0004 0.005 0.0057
Brugia malayi brahma associated protein 60 kDa 0.0118 0.4068 0.4636
Echinococcus multilocularis bromodomain containing protein 8 0.0004 0.005 0.008
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.1172 0.1869
Schistosoma mansoni bromodomain containing 0.0004 0.005 0.0082
Plasmodium vivax SET domain containing protein 0.0006 0.0097 0.0117
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0005 0.0072 0.0022
Echinococcus multilocularis zinc finger protein 0.0004 0.005 0.008
Echinococcus multilocularis bromodomain containing 2 0.0004 0.005 0.008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.1172 0.1927
Echinococcus granulosus protein kinase C binding protein 1 0.0004 0.005 0.008
Echinococcus multilocularis peregrin 0.0004 0.005 0.008
Plasmodium vivax hypothetical protein, conserved 0.0118 0.4068 1
Plasmodium vivax SET domain protein, putative 0.0036 0.1172 0.2792
Entamoeba histolytica ankyrin repeat protein, putative 0.0004 0.005 0.00000035201
Schistosoma mansoni bromodomain containing protein 0.0004 0.005 0.0082
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0042 0.1382 0.1575
Loa Loa (eye worm) hypothetical protein 0.0004 0.005 0.0057
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0042 0.1382 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.005 0.0057
Loa Loa (eye worm) hypothetical protein 0.0004 0.005 0.0057
Brugia malayi Bromodomain containing protein 0.0004 0.005 0.0057
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0004 0.005 0.008
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0042 0.1382 1
Schistosoma mansoni polybromo-1 0.0004 0.005 0.0082
Loa Loa (eye worm) hypothetical protein 0.0042 0.1382 0.1575
Brugia malayi brahma associated protein 60 kDa 0.0118 0.4068 0.4636
Echinococcus granulosus transcription initiation factor TFIID subunit 1 0.0004 0.005 0.008
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0004 0.005 0.008
Loa Loa (eye worm) hypothetical protein 0.0036 0.1172 0.1335
Echinococcus multilocularis SWI:SNF matrix associated 0.0118 0.4068 0.6489
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1849 0.3042
Schistosoma mansoni phd finger protein 0.0004 0.005 0.0082
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0118 0.4068 1
Echinococcus multilocularis ring and YY1 binding protein 0.0042 0.1382 0.2204
Leishmania major hypothetical protein, conserved 0.0042 0.1382 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.5906 0.9422
Brugia malayi SWIB/MDM2 domain containing protein 0.0118 0.4068 0.4636
Echinococcus granulosus Bromodomain containing protein 0.0004 0.005 0.008
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.1382 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.6079 0.9698
Brugia malayi Bromodomain containing protein 0.0004 0.005 0.0057
Schistosoma mansoni TRABID protein (C64 family) 0.0042 0.1382 0.2273
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.1716 0.4147
Schistosoma mansoni hypothetical protein 0.0004 0.005 0.0082
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1849 0.2108
Brugia malayi TAZ zinc finger family protein 0.0004 0.005 0.0057
Brugia malayi bromodomain containing protein 0.0004 0.005 0.0057
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0118 0.4068 0.4636
Onchocerca volvulus 0.0118 0.4068 0.4068
Onchocerca volvulus 0.0042 0.1382 0.1382
Brugia malayi PHD-finger family protein 0.0004 0.005 0.0057
Echinococcus granulosus global transcription activator snf2l2 0.0004 0.005 0.008
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.1716 0.1675
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.1382 1
Echinococcus granulosus ring and YY1 binding protein 0.0042 0.1382 0.2204
Echinococcus multilocularis muscleblind protein 0.018 0.6269 1
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0118 0.4068 1
Echinococcus granulosus zinc finger protein Ran binding 0.0042 0.1382 0.2204
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0042 0.1382 1
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0004 0.005 0.0082
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.8774 1
Echinococcus multilocularis muscleblind protein 1 0.018 0.6269 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0006 0.0097 0.0117
Echinococcus multilocularis global transcription activator snf2l2 0.0004 0.005 0.008
Loa Loa (eye worm) hypothetical protein 0.0004 0.005 0.0057
Schistosoma mansoni RNA binding protein 0.0042 0.1382 0.2273
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.1172 0.1927
Chlamydia trachomatis DNA topoisomerase I 0.0118 0.4068 0.5
Schistosoma mansoni brg-1 associated factor 0.0118 0.4068 0.6691
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.1716 0.4147
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.1172 0.1927
Echinococcus granulosus bromodomain containing protein 8 0.0004 0.005 0.008
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0005 0.0072 0.0022
Onchocerca volvulus Bromodomain adjacent to zinc finger domain protein 1A homolog 0.0004 0.005 0.005
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0004 0.005 0.0082
Echinococcus granulosus Zinc finger RanBP2 type 0.0042 0.1382 0.2204
Leishmania major hypothetical protein, conserved 0.0042 0.1382 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1849 0.2108
Loa Loa (eye worm) hypothetical protein 0.0042 0.1382 0.1575
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0042 0.1382 0.2204
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.1716 0.1675
Loa Loa (eye worm) brahma associated protein 0.0118 0.4068 0.4636
Loa Loa (eye worm) hypothetical protein 0.018 0.6269 0.7145

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 17.1 uM PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055] ChEMBL. No reference
Potency (functional) 0.1 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 0.7943 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (binding) 7.9433 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.7865 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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