Detailed information for compound 1622271

Basic information

Technical information
  • TDR Targets ID: 1622271
  • Name: 1-(2-pyridin-2-ylethyl)-3-(pyridin-2-ylmethyl ideneamino)thiourea
  • MW: 285.367 | Formula: C14H15N5S
  • H donors: 2 H acceptors: 2 LogP: 1.79 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(N/N=C/c1ccccn1)NCCc1ccccn1
  • InChi: 1S/C14H15N5S/c20-14(17-10-7-12-5-1-3-8-15-12)19-18-11-13-6-2-4-9-16-13/h1-6,8-9,11H,7,10H2,(H2,17,19,20)/b18-11+
  • InChiKey: YDGUQTMRXAWNNJ-WOJGMQOQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-(2-pyridyl)ethyl]-3-(2-pyridylmethyleneamino)thiourea
  • 2-Pyridinecarbaldehyde N-(2-(2-pyridinyl)ethyl)thiosemicarbazone
  • NCI60_024929
  • NSC670779
  • AIDS161092
  • AIDS-161092

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.0032 0.0033
Trypanosoma brucei heat shock protein, putative 0.034 0.0184 0.0527
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.034 0.0184 1
Loa Loa (eye worm) endoplasmin 0.034 0.0184 0.0184
Schistosoma mansoni Band 4.1-like protein 0.0206 0.0108 0.011
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.0032 0.0033
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0073 0.0032 0.0033
Echinococcus multilocularis epidermal growth factor receptor 0.0073 0.0032 0.0033
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni patched 1 0.0043 0.0015 0.0015
Schistosoma mansoni pyruvate dehydrogenase 0.5773 0.3271 0.3309
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Entamoeba histolytica filopodin, putative 0.0206 0.0108 0.5838
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Brugia malayi Raf kinase 0.0073 0.0032 0.0032
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus granulosus insulin receptor 0.0073 0.0032 0.0033
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0073 0.0032 0.0033
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0073 0.0032 0.0033
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0025 0.0005 0.0005
Trypanosoma brucei heat shock protein, putative 0.034 0.0184 0.0527
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0073 0.0032 0.0033
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Schistosoma mansoni endoplasmin 0.034 0.0184 0.0186
Echinococcus multilocularis talin 2 0.0206 0.0108 0.011
Loa Loa (eye worm) TK/FAK protein kinase 1.7619 1 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.0073 0.0032 0.0033
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Brugia malayi heat shock protein 90 0.034 0.0184 0.0184
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Trypanosoma cruzi ribonuclease inhibitor, putative 0.0206 0.0108 0.0308
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.034 0.0184 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0073 0.0032 0.0033
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0017 0.0017
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica serine/threonine kinase, putative 0.0073 0.0032 0.1677
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.034 0.0184 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0048 0.0049
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0073 0.0032 0.0033
Loa Loa (eye worm) TK/RYK protein kinase 0.0073 0.0032 0.0032
Plasmodium falciparum endoplasmin, putative 0.034 0.0184 1
Echinococcus granulosus talin 0.0206 0.0108 0.011
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0073 0.0032 0.0033
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Echinococcus granulosus tyrosine protein kinase 0.0073 0.0032 0.0033
Loa Loa (eye worm) TK/INSR protein kinase 0.0073 0.0032 0.0032
Echinococcus granulosus ephrin type A receptor 4 A 0.0073 0.0032 0.0033
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.034 0.0184 0.0527
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.2137 0.1205 0.8617
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Brugia malayi Tyrosine-protein kinase abl-1 0.0073 0.0032 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Loa Loa (eye worm) heat shock protein 90 0.034 0.0184 0.0184
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0073 0.0032 0.0033
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0073 0.0032 0.0033
Echinococcus multilocularis c src tyrosine kinase 0.0073 0.0032 0.0033
Echinococcus granulosus tyrosine protein kinase Srms 0.0073 0.0032 0.0033
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.0094 0.4086
Echinococcus multilocularis tyrosine protein kinase 0.0073 0.0032 0.0033
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Mycobacterium ulcerans DNA gyrase subunit B 0.034 0.0184 1
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0032 0.0033
Onchocerca volvulus DNA topoisomerase 2 homolog 0.034 0.0184 1
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0047 0.0048
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Loa Loa (eye worm) hypothetical protein 0.0151 0.0077 0.0077
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.034 0.0184 1
Schistosoma mansoni tyrosine kinase 1.7413 0.9883 1
Mycobacterium tuberculosis Two component sensor kinase MprB 0.034 0.0184 1
Brugia malayi hypothetical protein 0.0073 0.0032 0.0032
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Schistosoma mansoni pyruvate dehydrogenase 0.6113 0.3464 0.3505
Echinococcus granulosus merlin:moesin:ezrin:radixin 0.0206 0.0108 0.011
Echinococcus multilocularis tyrosine kinase 0.0073 0.0032 0.0033
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.0032 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0017 0.0017
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0073 0.0032 0.0033
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Echinococcus multilocularis unc 112 protein 0.0206 0.0108 0.011
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Trypanosoma brucei heat shock protein 90, putative 0.034 0.0184 0.0527
Echinococcus granulosus FERM domain containing protein 3 0.0206 0.0108 0.011
Loa Loa (eye worm) TOPoisomerase family member 0.034 0.0184 0.0184
Trypanosoma brucei protein kinase, putative 0.0073 0.0032 0.0088
Entamoeba histolytica serine/threonine kinase, putative 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus multilocularis talin 0.0206 0.0108 0.011
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Trichomonas vaginalis TK family protein kinase 0.0073 0.0032 0.1677
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Loa Loa (eye worm) neurofibromin 2 isoform 8 0.0206 0.0108 0.0108
Onchocerca volvulus 0.0206 0.0108 0.4999
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Entamoeba histolytica tyrosin kinase, putative 0.0073 0.0032 0.1677
Echinococcus multilocularis Pleckstrin y 0.0206 0.0108 0.011
Trypanosoma cruzi protein kinase, putative 0.0073 0.0032 0.0088
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0047 0.0048
Entamoeba histolytica tyrosin kinase, putative 0.0073 0.0032 0.1677
Echinococcus multilocularis tyrosine protein kinase HCK 0.0073 0.0032 0.0033
Echinococcus granulosus protein kinase 0.0073 0.0032 0.0033
Echinococcus granulosus SPRY domain containing protein 0.0206 0.0108 0.011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0043 0.0015 0.0015
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0073 0.0032 0.0033
Echinococcus multilocularis tyrosine protein kinase Abl 0.0073 0.0032 0.0033
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0073 0.0032 0.0033
Mycobacterium tuberculosis Probable sensor protein KdpD 0.034 0.0184 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0073 0.0032 0.0033
Toxoplasma gondii heat shock protein 90, putative 0.034 0.0184 0.1306
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0073 0.0032 0.1677
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0073 0.0032 0.1677
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0002 0.0002
Brugia malayi hypothetical protein 0.0206 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trypanosoma cruzi DNA topoisomerase II, putative 0.034 0.0184 0.0527
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0015 0.0015
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Echinococcus granulosus tyrosine protein kinase Lyn 0.0073 0.0032 0.0033
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus multilocularis heat shock protein 90 0.034 0.0184 0.0186
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0032 0.1677
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0005 0.0011
Echinococcus granulosus retinal guanylyl cyclase 2 0.0073 0.0032 0.0033
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0073 0.0032 0.0033
Echinococcus multilocularis protein KINase family member (kin 25) 0.0073 0.0032 0.0033
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0073 0.0032 0.0033
Leishmania major hypothetical protein, conserved 0.034 0.0184 0.0527
Schistosoma mansoni hypothetical protein 0.0041 0.0014 0.0014
Loa Loa (eye worm) TK/ALK protein kinase 0.0073 0.0032 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus granulosus tyrosine protein kinase Fyn 0.0073 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Echinococcus granulosus protein tyrosine phosphatase non receptor type 0.0206 0.0108 0.011
Entamoeba histolytica serine/threonine kinase, putative 0.0073 0.0032 0.1677
Echinococcus granulosus Pleckstrin y 0.0206 0.0108 0.011
Mycobacterium ulcerans two component regulator - sensor kinase 0.034 0.0184 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.6113 0.3464 0.3464
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0073 0.0032 0.0033
Schistosoma mansoni hypothetical protein 0.0041 0.0014 0.0014
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Schistosoma mansoni heat shock protein 0.034 0.0184 0.0186
Trypanosoma brucei heat shock protein, putative 0.034 0.0184 0.0527
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0073 0.0032 0.0033
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.034 0.0184 1
Echinococcus multilocularis muscleblind protein 0.0151 0.0077 0.0077
Trypanosoma brucei heat shock protein 90, putative 0.034 0.0184 0.0527
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Brugia malayi FERM domain 0.0206 0.0108 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0073 0.0032 0.0032
Schistosoma mansoni talin 2 0.0206 0.0108 0.011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.034 0.0184 0.0184
Entamoeba histolytica ankyrin repeat protein 0.0073 0.0032 0.1677
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.2137 0.1205 0.3476
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.034 0.0184 0.0527
Echinococcus multilocularis SPRY domain containing protein 0.0206 0.0108 0.011
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.034 0.0184 0.5
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.034 0.0184 1
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Loa Loa (eye worm) TK/ROR protein kinase 0.0073 0.0032 0.0032
Trypanosoma brucei developmentally regulated phosphoprotein 0.6113 0.3464 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0005 0.0201
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Trypanosoma brucei heat shock protein, putative 0.034 0.0184 0.0527
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Echinococcus multilocularis FERM domain containing protein 5 0.0206 0.0108 0.011
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Echinococcus granulosus tyrosine protein kinase Src42A 0.0073 0.0032 0.0033
Echinococcus granulosus natriuretic peptide receptor 1 0.0073 0.0032 0.0033
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.034 0.0184 1
Echinococcus multilocularis FERM central domain 0.0206 0.0108 0.011
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Mycobacterium tuberculosis Conserved protein 0.034 0.0184 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0073 0.0032 0.0033
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Echinococcus granulosus H17g protein tegumental antigen 0.0206 0.0108 0.011
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Trypanosoma cruzi heat shock protein 90, putative 0.034 0.0184 0.0527
Plasmodium vivax DNA topoisomerase II, putative 0.034 0.0184 1
Echinococcus granulosus heat shock protein 90 0.034 0.0184 0.0186
Loa Loa (eye worm) hypothetical protein 0.0034 0.001 0.001
Entamoeba histolytica ankyrin repeat protein 0.0073 0.0032 0.1677
Echinococcus multilocularis transfer RNA-Thr 0.0073 0.0032 0.0033
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Loa Loa (eye worm) TK/Met protein kinase 0.0073 0.0032 0.0032
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.2137 0.1205 0.3476
Trichomonas vaginalis receptor histidine kinase, putative 0.034 0.0184 1
Trichomonas vaginalis sensor histidine kinase, putative 0.034 0.0184 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0073 0.0032 0.0033
Brugia malayi Moesin/ezrin/radixin homolog 1 0.0206 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0073 0.0032 0.0032
Toxoplasma gondii protein kinase domain-containing protein 0.0073 0.0032 0.0219
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Echinococcus granulosus retinal guanylyl cyclase 2 0.0073 0.0032 0.0033
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Trypanosoma brucei heat shock protein, putative 0.034 0.0184 0.0527
Plasmodium falciparum DNA topoisomerase 2 0.034 0.0184 1
Echinococcus granulosus FERM domain containing protein 5 0.0206 0.0108 0.011
Brugia malayi Talin 1 0.0206 0.0108 0.0108
Trypanosoma cruzi ribonuclease inhibitor, putative 0.0206 0.0108 0.0308
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus multilocularis epidermal growth factor receptor 0.0073 0.0032 0.0033
Echinococcus multilocularis tyrosine protein kinase Blk 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0017 0.0017
Onchocerca volvulus 4.1 G protein, putative homolog 0.0206 0.0108 0.4999
Echinococcus multilocularis tyrosine protein kinase shark 0.0073 0.0032 0.0033
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Loa Loa (eye worm) TK/EPH protein kinase 0.0073 0.0032 0.0032
Echinococcus multilocularis FERM central domain 0.0206 0.0108 0.011
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Entamoeba histolytica serine/threonine kinase, putative 0.0073 0.0032 0.1677
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0073 0.0032 0.0033
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Plasmodium falciparum tyrosine kinase-like protein 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Plasmodium vivax DNA gyrase subunit B, putative 0.034 0.0184 1
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Mycobacterium ulcerans two component sensor kinase MprB 0.034 0.0184 1
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.0032 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Brugia malayi protein-tyrosine-phosphatase 0.0206 0.0108 0.0108
Trypanosoma cruzi ribonuclease inhibitor, putative 0.0206 0.0108 0.0308
Brugia malayi hypothetical protein 0.0073 0.0032 0.0032
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0073 0.0032 0.0032
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Brugia malayi C-terminal src kinase protein 1 0.0073 0.0032 0.0032
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.2137 0.1205 0.3476
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Echinococcus multilocularis raf serine:threonine protein kinase 0.0073 0.0032 0.0033
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0073 0.0032 0.1677
Echinococcus granulosus tyrosine kinase 0.0073 0.0032 0.0033
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0073 0.0032 0.0033
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0073 0.0032 0.0219
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Brugia malayi GH28553p 0.0206 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0073 0.0032 0.0033
Brugia malayi Tyrosine-protein kinase PR2 0.0073 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0108 0.5838
Entamoeba histolytica heat shock protein 90, putative 0.034 0.0184 1
Entamoeba histolytica receptor protein kinase, putative 0.0073 0.0032 0.1677
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0032 0.1677
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0032 0.1677
Plasmodium vivax protein kinase, putative 0.0073 0.0032 0.1677
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Loa Loa (eye worm) hypothetical protein 0.034 0.0184 0.0184
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.034 0.0184 0.1306
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Echinococcus granulosus epidermal growth factor receptor 0.0073 0.0032 0.0033
Loa Loa (eye worm) TK/EGFR protein kinase 0.0073 0.0032 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0073 0.0032 0.0088
Brugia malayi Ferm domain 0.0206 0.0108 0.0108
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0073 0.0032 0.0032
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0073 0.0032 0.0033
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0017 0.0017
Echinococcus multilocularis insulin receptor 0.0073 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0073 0.0032 0.0033
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0073 0.0032 0.0032
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0073 0.0032 0.0033
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.034 0.0184 1
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Loa Loa (eye worm) moesin 0.0206 0.0108 0.0108
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Plasmodium falciparum protein kinase, putative 0.0073 0.0032 0.1677
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.034 0.0184 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0073 0.0032 0.0033
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Schistosoma mansoni heat shock protein 0.034 0.0184 0.0186
Schistosoma mansoni DNA topoisomerase II 0.034 0.0184 0.0186
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.034 0.0184 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0017 0.0017
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0073 0.0032 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0017 0.0017
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Echinococcus granulosus expressed conserved protein 0.0093 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0108 0.5838
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Mycobacterium ulcerans putative regultory protein 0.034 0.0184 1
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0073 0.0032 0.0219
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0073 0.0032 0.0033
Giardia lamblia Pms1-like protein 0.034 0.0184 1
Brugia malayi Guanylyl cyclase protein 23 0.0073 0.0032 0.0032
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Giardia lamblia Protein 21.1 0.0073 0.0032 0.1677
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Leishmania major protein kinase, putative 0.0073 0.0032 0.0088
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.034 0.0184 1
Echinococcus multilocularis integrin linked protein kinase 0.0073 0.0032 0.0033
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0073 0.0032 0.0088
Trichomonas vaginalis protein kinase atn1, putative 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0151 0.0077 0.0077
Echinococcus granulosus raf serine:threonine protein kinase 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus multilocularis Ezrin radixin moesin ERM 0.0206 0.0108 0.011
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0073 0.0032 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0032 0.0033
Brugia malayi N-terminal motif family protein 0.0182 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0034 0.001 0.0011
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0073 0.0032 0.0033
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0002 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0032 0.1677
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.0072 0.0072
Echinococcus multilocularis expressed conserved protein 0.0093 0.0044 0.0044
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.0032 0.0033
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Chlamydia trachomatis DNA gyrase subunit B 0.034 0.0184 0.5
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0017 0.0017
Entamoeba histolytica serine/threonine kinase, putative 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Plasmodium vivax tyrosine kinase-like protein, putative 0.0073 0.0032 0.1677
Entamoeba histolytica heat shock protein 90, putative 0.034 0.0184 1
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.034 0.0184 0.0527
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Loa Loa (eye worm) TK/ACK protein kinase 0.0073 0.0032 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Entamoeba histolytica tyrosin kinase, putative 0.0073 0.0032 0.1677
Echinococcus granulosus tyrosine protein kinase HCK 0.0073 0.0032 0.0033
Brugia malayi ephrin receptor 1 precursor 0.0073 0.0032 0.0032
Leishmania major mitochondrial DNA topoisomerase II 0.034 0.0184 0.0527
Entamoeba histolytica cysteine surface protein, putative 0.0073 0.0032 0.1677
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Toxoplasma gondii heat shock protein HSP90 0.034 0.0184 0.1306
Echinococcus multilocularis FERM domain containing protein 3 0.0206 0.0108 0.011
Giardia lamblia Kinase, NEK 0.0073 0.0032 0.1677
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0073 0.0032 0.0032
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.034 0.0184 1
Plasmodium falciparum DNA gyrase subunit B 0.034 0.0184 1
Toxoplasma gondii DNA topoisomerase 2, putative 0.034 0.0184 0.1306
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0032 0.1677
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0206 0.0108 0.011
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.0032 0.0032
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Echinococcus multilocularis ezrin 0.0206 0.0108 0.011
Brugia malayi integrin-linked kinase 0.0073 0.0032 0.0032
Trypanosoma brucei heat shock protein, putative 0.034 0.0184 0.0527
Onchocerca volvulus DNA topoisomerase 2 homolog 0.034 0.0184 1
Trypanosoma brucei Flagellum attachment zone protein 20 0.0073 0.0032 0.0088
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0073 0.0032 0.0033
Echinococcus granulosus epidermal growth factor receptor 0.0073 0.0032 0.0033
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0073 0.0032 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0032 0.1677
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0073 0.0032 0.1677
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0206 0.0108 0.011
Echinococcus granulosus integrin linked protein kinase 0.0073 0.0032 0.0033
Trypanosoma cruzi protein kinase, putative 0.0073 0.0032 0.0088
Brugia malayi Probable DNA topoisomerase II 0.034 0.0184 0.0184
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.0032 0.0033
Schistosoma mansoni ap endonuclease 0.0019 0.0002 0.0002
Schistosoma mansoni serine/threonine RGC 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus granulosus FERM domain containing protein 5 0.0206 0.0108 0.011
Entamoeba histolytica leucine-rich repeat containing protein 0.0206 0.0108 0.5838
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.034 0.0184 0.0527
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.002 0.002
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Schistosoma mansoni endoplasmin 0.034 0.0184 0.0186
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.034 0.0184 1
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Chlamydia trachomatis DNA gyrase subunit B 0.034 0.0184 0.5
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.034 0.0184 1
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Echinococcus granulosus ezrin 0.0206 0.0108 0.011
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0073 0.0032 0.0032
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.034 0.0184 1
Schistosoma mansoni Radixin 0.0206 0.0108 0.011
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0073 0.0032 0.0033
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0073 0.0032 0.0033
Brugia malayi hypothetical protein 0.0206 0.0108 0.0108
Schistosoma mansoni merlin/moesin/ezrin/radixin 0.0206 0.0108 0.011
Plasmodium falciparum protein kinase, putative 0.0073 0.0032 0.1677
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.0032 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Brugia malayi Muscleblind-like protein 0.0151 0.0077 0.0077
Schistosoma mansoni ap endonuclease 0.0019 0.0002 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Toxoplasma gondii STE kinase 0.0073 0.0032 0.0219
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus multilocularis kinase suppressor of Ras 1 0.0073 0.0032 0.0033
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0073 0.0032 0.0033
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.002 0.002
Brugia malayi Ferm domain 0.0206 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.005 0.002 0.002
Onchocerca volvulus 0.0206 0.0108 0.4999
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Echinococcus granulosus DNA topoisomerase 2 alpha 0.034 0.0184 0.0186
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0073 0.0032 0.0033
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0073 0.0032 0.0088
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.034 0.0184 0.1306
Echinococcus multilocularis heat shock protein 70 0.0073 0.0032 0.0033
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0002 0.0002
Brugia malayi Receptor family ligand binding region containing protein 0.0073 0.0032 0.0032
Plasmodium falciparum tyrosine kinase-like protein 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Brugia malayi kinase, mitochondrial precursor 0.6113 0.3464 0.3464
Loa Loa (eye worm) TK/DDR protein kinase 0.0073 0.0032 0.0032
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Echinococcus multilocularis FERM domain containing protein 3 0.0206 0.0108 0.011
Mycobacterium tuberculosis Probable two component sensor kinase 0.034 0.0184 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Echinococcus granulosus tyrosine protein kinase Fyn 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.0032 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0032 0.0033
Echinococcus multilocularis protein kinase 0.0073 0.0032 0.0033
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Entamoeba histolytica filopodin, putative 0.0206 0.0108 0.5838
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.034 0.0184 0.0186
Echinococcus multilocularis tyrosine kinase 0.0073 0.0032 0.0033
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.034 0.0184 1
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Echinococcus multilocularis FERM domain containing protein 5 0.0206 0.0108 0.011
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0206 0.0108 0.011
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0073 0.0032 0.0033
Brugia malayi hypothetical protein 0.0073 0.0032 0.0032
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0073 0.0032 0.0033
Plasmodium vivax heat shock protein 86, putative 0.034 0.0184 1
Loa Loa (eye worm) TK/CSK protein kinase 0.0073 0.0032 0.0032
Echinococcus multilocularis 0.0206 0.0108 0.011
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0047 0.2501
Echinococcus multilocularis heat shock protein 0.034 0.0184 0.0186
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.034 0.0184 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0073 0.0032 0.0033
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0073 0.0032 0.0033
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.0032 0.0033
Leishmania major hypothetical protein, conserved 0.0073 0.0032 0.0088
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.034 0.0184 1
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Brugia malayi protein-tyrosine kinase 0.0073 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0182 0.0094 0.0094
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0032 0.1677
Echinococcus multilocularis protein patched 0.0043 0.0015 0.0015
Echinococcus multilocularis ephrin type A receptor 4 A 0.0073 0.0032 0.0033
Trypanosoma cruzi heat shock protein 85, putative 0.034 0.0184 0.0527
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0015 0.0015
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Echinococcus multilocularis myosin viia 0.0206 0.0108 0.011
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Brugia malayi MyTH4 domain containing protein 0.0206 0.0108 0.0108
Echinococcus granulosus kinase suppressor of Ras 1 0.0073 0.0032 0.0033
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0073 0.0032 0.0032
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0073 0.0032 0.0033
Mycobacterium tuberculosis Possible two component sensor kinase 0.034 0.0184 1
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Entamoeba histolytica DNA topoisomerase II, putative 0.034 0.0184 1
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.034 0.0184 1
Brugia malayi SH2 domain containing protein 0.0073 0.0032 0.0032
Schistosoma mansoni pyruvate dehydrogenase 0.5773 0.3271 0.3309
Echinococcus granulosus SPRY domain containing protein 0.0206 0.0108 0.011
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0005 0.0026
Echinococcus granulosus receptor type guanylyl cyclase 0.0073 0.0032 0.0033
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.034 0.0184 0.5
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Echinococcus granulosus tyrosine kinase 0.0073 0.0032 0.0033
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0073 0.0032 0.0033
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0017 0.0017
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0073 0.0032 0.0033
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0206 0.0108 0.011
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0005 0.0011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.6113 0.3464 0.3505
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0032 0.0033
Trichomonas vaginalis endoplasmin, putative 0.034 0.0184 1
Echinococcus granulosus protein 4.1 0.0206 0.0108 0.011
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0073 0.0032 0.0033
Loa Loa (eye worm) TK/ABL protein kinase 0.0073 0.0032 0.0032
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.034 0.0184 1
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.0072 0.0072
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.034 0.0184 0.5
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus multilocularis activated cdc42 kinase 1 0.0073 0.0032 0.0033
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.034 0.0184 1
Echinococcus granulosus radixin 0.0206 0.0108 0.011
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Echinococcus granulosus tyrosine protein kinase Src64B 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Loa Loa (eye worm) MyTH4 domain-containing protein 0.0206 0.0108 0.0108
Echinococcus multilocularis muscleblind protein 1 0.0151 0.0077 0.0077
Loa Loa (eye worm) protein kinase domain-containing protein 0.0073 0.0032 0.0032
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.0032 0.0033
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0073 0.0032 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0032 0.1677
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Echinococcus granulosus unc 112 protein 0.0206 0.0108 0.011
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0206 0.0108 0.011
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus multilocularis protein tyrosine kinase 1.7413 0.9883 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Onchocerca volvulus 0.0206 0.0108 0.4999
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0005 0.0201
Brugia malayi hypothetical protein 0.0206 0.0108 0.0108
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0015 0.0015
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0073 0.0032 0.1677
Echinococcus multilocularis merlin:moesin:ezrin:radixin 0.0206 0.0108 0.011
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Echinococcus granulosus myosin viia 0.0206 0.0108 0.011
Brugia malayi Furin-like cysteine rich region family protein 0.0073 0.0032 0.0032
Trypanosoma brucei Heat shock protein 83, putative 0.034 0.0184 0.0527
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0099 0.0047 0.0047
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus multilocularis FL cytokine receptor 0.0073 0.0032 0.0033
Echinococcus multilocularis protein dispatched 1 0.0049 0.0019 0.0019
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0073 0.0032 0.0033
Loa Loa (eye worm) TK protein kinase 0.0073 0.0032 0.0032
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Brugia malayi SH2 domain containing protein 0.0073 0.0032 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Leishmania major DNA topoisomerase ii 0.034 0.0184 0.0527
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Trichomonas vaginalis protein MLP1, putative 0.0206 0.0108 0.5838
Echinococcus multilocularis receptor type guanylyl cyclase 0.0073 0.0032 0.0033
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0073 0.0032 0.0033
Echinococcus granulosus tyrosine kinase 0.0073 0.0032 0.0033
Trichomonas vaginalis protein tyrosine kinase, putative 0.0073 0.0032 0.1677
Onchocerca volvulus Putative 4.1 G protein 0.0206 0.0108 0.4999
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Echinococcus granulosus talin 2 0.0206 0.0108 0.011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Brugia malayi SRC-1 0.0073 0.0032 0.0032
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.034 0.0184 1
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0073 0.0032 0.0033
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0073 0.0032 0.0032
Entamoeba histolytica hypothetical protein, conserved 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.034 0.0184 1
Brugia malayi GRP1 binding protein 0.0206 0.0108 0.0108
Echinococcus multilocularis SPRY domain containing protein 0.0206 0.0108 0.011
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0073 0.0032 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Echinococcus granulosus c src tyrosine kinase 0.0073 0.0032 0.0033
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.6113 0.3464 0.3505
Trypanosoma cruzi hypothetical protein 0.0206 0.0108 0.0308
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Leishmania major hypothetical protein, conserved 0.0025 0.0005 0.0011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0017 0.0017
Plasmodium falciparum protein kinase, putative 0.0073 0.0032 0.1677
Echinococcus granulosus Ezrin radixin moesin ERM 0.0206 0.0108 0.011
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0206 0.0108 0.011
Trichomonas vaginalis DNA topoisomerase II, putative 0.034 0.0184 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0005 0.0011
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Trypanosoma cruzi DNA topoisomerase II, putative 0.034 0.0184 0.0527
Onchocerca volvulus 0.0206 0.0108 0.4999
Treponema pallidum chemotaxis histidine kinase (cheA) 0.034 0.0184 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Mycobacterium leprae Probable two-component sensor kinase 0.034 0.0184 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.0032 0.0033
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Echinococcus granulosus protein tyrosine kinase 1.7413 0.9883 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.2477 0.1398 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0108 0.5838
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0032 0.1677
Trypanosoma brucei Pseudokinase, putative 0.0073 0.0032 0.0088
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0073 0.0032 0.0033
Echinococcus multilocularis H17g protein, tegumental antigen 0.0206 0.0108 0.011
Echinococcus granulosus heat shock protein 0.034 0.0184 0.0186
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus granulosus activin receptor type 0.0073 0.0032 0.0033
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Echinococcus multilocularis protein kinase 0.0073 0.0032 0.0033
Trichomonas vaginalis receptor histidine kinase, putative 0.034 0.0184 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0047 0.0047
Leishmania major protein kinase, putative 0.0073 0.0032 0.0088
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Entamoeba histolytica serine/threonine kinase, putative 0.0073 0.0032 0.1677
Trypanosoma brucei DNA topoisomerase II beta, putative 0.034 0.0184 0.0527
Brugia malayi neurofibromatosis homolog protein 1 0.0206 0.0108 0.0108
Leishmania major developmentally regulated phosphoprotein-like protein 0.6113 0.3464 1
Schistosoma mansoni tyrosine protein kinase 0.0073 0.0032 0.0033
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0073 0.0032 0.0219
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni ephrin receptor 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Brugia malayi bone morphogenetic protein type 1 receptor 0.0073 0.0032 0.0032
Entamoeba histolytica receptor protein kinase, putative 0.0073 0.0032 0.1677
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Entamoeba histolytica hypothetical protein 0.0073 0.0032 0.1677
Echinococcus granulosus FERM central domain 0.0206 0.0108 0.011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Schistosoma mansoni ephrin receptor 0.0073 0.0032 0.0033
Echinococcus granulosus tyrosine protein kinase ABL1 0.0073 0.0032 0.0033
Loa Loa (eye worm) SRC-1 0.0073 0.0032 0.0032
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.034 0.0184 1
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0073 0.0032 0.0032
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Loa Loa (eye worm) serine/threonine protein kinase 0.0073 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0108 0.5838
Echinococcus granulosus FERM central domain 0.0206 0.0108 0.011
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Echinococcus granulosus tyrosine protein kinase shark 0.0073 0.0032 0.0033
Giardia lamblia Heat shock protein HSP 90-alpha 0.034 0.0184 1
Echinococcus granulosus muscleblind protein 0.0151 0.0077 0.0077
Trichomonas vaginalis heat shock protein, putative 0.034 0.0184 1
Mycobacterium leprae Probable two component sensor kinase MprB 0.034 0.0184 0.5
Toxoplasma gondii protein kinase 0.0073 0.0032 0.0219
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0073 0.0032 0.0032
Echinococcus granulosus fibroblast growth factor receptor 4 0.0073 0.0032 0.0033
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.0032 0.0033
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.0032 0.0032
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0073 0.0032 0.0033
Echinococcus granulosus activated cdc42 kinase 1 0.0073 0.0032 0.0033
Echinococcus granulosus FERM domain containing protein 3 0.0206 0.0108 0.011
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0073 0.0032 0.0033
Trypanosoma cruzi heat shock protein 85, putative 0.034 0.0184 0.0527
Plasmodium vivax hypothetical protein, conserved 0.034 0.0184 1
Brugia malayi hypothetical protein 0.0025 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase pr2 0.0073 0.0032 0.0033
Schistosoma mansoni merlin/moesin/ezrin/radixin 0.0206 0.0108 0.011
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Brugia malayi DNA topoisomerase II, alpha isozyme 0.034 0.0184 0.0184
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.034 0.0184 1
Giardia lamblia Kinase, NEK 0.0073 0.0032 0.1677
Trypanosoma brucei heat shock protein, putative 0.034 0.0184 0.0527
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.001 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0041 0.0014 0.0014
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0015 0.0015
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0073 0.0032 0.0088
Echinococcus granulosus tyrosine protein kinase Fyn 0.0073 0.0032 0.0033
Echinococcus multilocularis radixin 0.0206 0.0108 0.011
Entamoeba histolytica protein kinase, putative 0.0073 0.0032 0.1677
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.0032 0.0033
Plasmodium falciparum heat shock protein 90 0.034 0.0184 1
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.034 0.0184 1
Echinococcus multilocularis activin receptor type 0.0073 0.0032 0.0033
Schistosoma mansoni hypothetical protein 0.0041 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.034 0.0184 0.0184
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.002 0.002
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Schistosoma mansoni merlin/moesin/ezrin/radixin 0.0206 0.0108 0.011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Echinococcus granulosus SPRY domain containing protein 0.0206 0.0108 0.011
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0073 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.034 0.0184 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Trypanosoma cruzi heat shock protein 90, putative 0.034 0.0184 0.0527
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0073 0.0032 0.1677
Giardia lamblia Kinase 0.0073 0.0032 0.1677
Brugia malayi Endoplasmin precursor 0.034 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0206 0.0108 0.0108
Brugia malayi CHE-14 protein 0.0043 0.0015 0.0015
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.0032 0.0033
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0015 0.0736
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0032 0.0032
Trypanosoma cruzi heat shock protein 85, putative 0.034 0.0184 0.0527
Plasmodium vivax tyrosine kinase-like protein, putative 0.0073 0.0032 0.1677
Schistosoma mansoni talin 0.0206 0.0108 0.011
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0073 0.0032 0.1677
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0073 0.0032 0.1677
Trichomonas vaginalis STE family protein kinase 0.0073 0.0032 0.1677
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.034 0.0184 1
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.6113 0.3464 0.3505
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0005 0.0201
Schistosoma mansoni protein tyrosine kinase 0.0073 0.0032 0.0033
Schistosoma mansoni hypothetical protein 0.0206 0.0108 0.011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0002 0.0002
Trichomonas vaginalis heat shock protein, putative 0.034 0.0184 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0073 0.0032 0.0033
Trypanosoma cruzi Heat shock protein 83, putative 0.034 0.0184 0.0527
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.6113 0.3464 1
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Echinococcus granulosus activated cdc42 kinase 1 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Schistosoma mansoni tyrosine kinase 0.0073 0.0032 0.0033
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0073 0.0032 0.0033
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Brugia malayi Ferm domain (protein4.1-ezrin-radixin-moesin) family protein 4-like 0.0206 0.0108 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Loa Loa (eye worm) hypothetical protein 0.0052 0.0021 0.0021
Plasmodium vivax endoplasmin, putative 0.034 0.0184 1
Onchocerca volvulus 0.0206 0.0108 0.4999
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0032 0.1677
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0073 0.0032 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0032 0.1677
Trypanosoma brucei heat shock protein, putative 0.034 0.0184 0.0527
Echinococcus multilocularis protein tyrosine phosphatase, non receptor type 0.0206 0.0108 0.011
Trypanosoma brucei DNA topoisomerase ii 0.034 0.0184 0.0527
Brugia malayi Protein kinase domain containing protein 0.0073 0.0032 0.0032
Entamoeba histolytica tyrosine kinase, putative 0.0073 0.0032 0.1677
Leishmania major heat shock protein 83-1 0.034 0.0184 0.0527
Schistosoma mansoni protein kinase 0.0073 0.0032 0.0033
Entamoeba histolytica tyrosin kinase, putative 0.0073 0.0032 0.1677
Brugia malayi Unc-112 related protein. 0.0206 0.0108 0.0108
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.034 0.0184 0.0527

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.208 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.984 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.897 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.741 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.954 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.831 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.72 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.582 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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