TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 652.716 | Formula: C34H30F2N8O2S
H donors: 2 H acceptors: 4 LogP: 6.29 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: CN(c1c(cccc1c1nc2n(c1c1ccnc(n1)Nc1cccc(c1)N1CCOCC1)ccs2)NC(=O)c1c(F)cccc1F)C
InChi: 1S/C34H30F2N8O2S/c1-42(2)30-23(8-4-11-26(30)39-32(45)28-24(35)9-5-10-25(28)36)29-31(44-16-19-47-34(44)41-29)27-12-13-37-33(40-27)38-21-6-3-7-22(20-21)43-14-17-46-18-15-43/h3-13,16,19-20H,14-15,17-18H2,1-2H3,(H,39,45)(H,37,38,40)
InChiKey: SYVFMRBHXSGATD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	FYN proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	No references
Homo sapiens	LCK proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	No references
Homo sapiens	mitogen-activated protein kinase kinase kinase kinase 4	Starlite/ChEMBL	No references
Homo sapiens	TAO kinase 1	Starlite/ChEMBL	No references
Homo sapiens	protein kinase N2	Starlite/ChEMBL	No references
Homo sapiens	protein tyrosine kinase 2	Starlite/ChEMBL	No references
Homo sapiens	Bruton agammaglobulinemia tyrosine kinase	Starlite/ChEMBL	No references
Homo sapiens	misshapen-like kinase 1	Starlite/ChEMBL	No references
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	No references
Homo sapiens	ABL proto-oncogene 1, non-receptor tyrosine kinase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	protein tyrosine kinase	Get druggable targets OG5_130513	All targets in OG5_130513
Echinococcus multilocularis	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma mansoni	protein kinase	Get druggable targets OG5_128641	All targets in OG5_128641
Loa Loa (eye worm)	TK/FAK protein kinase	Get druggable targets OG5_130513	All targets in OG5_130513
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	serine:threonine protein kinase TAO1	Get druggable targets OG5_129521	All targets in OG5_129521
Schistosoma japonicum	Mitogen-activated protein kinase kinase kinase kinase 4, putative	Get druggable targets OG5_128641	All targets in OG5_128641
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_130513	All targets in OG5_130513
Schistosoma japonicum	Serine/threonine-protein kinase N2, putative	Get druggable targets OG5_130229	All targets in OG5_130229
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	IPR000437,Prokaryotic membrane lipoprotein lipid attachment site,domain-containing	Get druggable targets OG5_128641	All targets in OG5_128641
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	protein tyrosine kinase	Get druggable targets OG5_130513	All targets in OG5_130513
Echinococcus multilocularis	serine:threonine protein kinase TAO1	Get druggable targets OG5_129521	All targets in OG5_129521
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131234	All targets in OG5_131234
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Serine/threonine-protein kinase mig-15, putative	Get druggable targets OG5_128641	All targets in OG5_128641
Echinococcus granulosus	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	expressed protein	Get druggable targets OG5_130513	All targets in OG5_130513
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	protein kinase	Get druggable targets OG5_128641	All targets in OG5_128641
Echinococcus multilocularis	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129521	All targets in OG5_129521
Schistosoma japonicum	IPR000961,Protein kinase, C-terminal,domain-containing	Get druggable targets OG5_130229	All targets in OG5_130229
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase ABL1, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Loa Loa (eye worm)	STE/STE20/TAO protein kinase	Get druggable targets OG5_129521	All targets in OG5_129521
Schistosoma japonicum	ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative	Get druggable targets OG5_128641	All targets in OG5_128641
Schistosoma japonicum	expressed protein	Get druggable targets OG5_130513	All targets in OG5_130513
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	serine:threonine protein kinase N2	Get druggable targets OG5_130229	All targets in OG5_130229
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus multilocularis		Get druggable targets OG5_128641	All targets in OG5_128641
Schistosoma japonicum	Serine/threonine-protein kinase mig-15, putative	Get druggable targets OG5_128641	All targets in OG5_128641
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Abl	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus granulosus	serine:threonine protein kinase mig 15	Get druggable targets OG5_128641	All targets in OG5_128641
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Tyrosine-protein kinase BTK, putative	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma japonicum	expressed protein	Get druggable targets OG5_130229	All targets in OG5_130229
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	Protein tyrosine kinase 2 beta, putative	Get druggable targets OG5_130513	All targets in OG5_130513
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_130513	All targets in OG5_130513
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma japonicum	ko:K04429 thousand and one amino acid protein kinase, putative	Get druggable targets OG5_129521	All targets in OG5_129521
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234
Brugia malayi	Hr1 repeat family protein	Get druggable targets OG5_130229	All targets in OG5_130229
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	protein kinase	Get druggable targets OG5_128641	All targets in OG5_128641
Loa Loa (eye worm)	STE/STE20/MSN protein kinase	Get druggable targets OG5_128641	All targets in OG5_128641
Echinococcus multilocularis	serine:threonine protein kinase N2	Get druggable targets OG5_130229	All targets in OG5_130229
Echinococcus granulosus	serine:threonine protein kinase N2	Get druggable targets OG5_130229	All targets in OG5_130229
Loa Loa (eye worm)	AGC/PKN protein kinase	Get druggable targets OG5_130229	All targets in OG5_130229
Echinococcus granulosus	serine:threonine protein kinase N2	Get druggable targets OG5_130229	All targets in OG5_130229
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320
Brugia malayi	hypothetical protein	Get druggable targets OG5_129521	All targets in OG5_129521
Schistosoma japonicum	Serine/threonine-protein kinase N1, putative	Get druggable targets OG5_130229	All targets in OG5_130229
Brugia malayi	Serine/threonine-protein kinase SULU	Get druggable targets OG5_129521	All targets in OG5_129521
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128641	All targets in OG5_128641
Brugia malayi	probable protein kinase	Get druggable targets OG5_128641	All targets in OG5_128641
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Brugia malayi	Tyrosine-protein kinase abl-1	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129320	All targets in OG5_129320
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK/ABL protein kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_130229	All targets in OG5_130229

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	major cysteine proteinase, putative	0.0047	0.0495	0.4859
Brugia malayi	protein-tyrosine kinase	0.0058	0.0669	0.1405
Echinococcus multilocularis	NCK adaptor protein	0.0031	0.0246	0.0245
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0108	0.0225
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0073	0.0913	0.0912
Trypanosoma cruzi	cysteine peptidase, putative	0.006	0.0698	0.9602
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0152	0.217	0.2169
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0017	0.0021	0.0021
Brugia malayi	SH2 domain containing protein	0.0022	0.0108	0.0225
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0031	0.0246	0.0245
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0073	0.0913	0.0913
Echinococcus multilocularis	serine:threonine protein kinase N2	0.017	0.2455	0.2454
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0073	0.0913	0.0913
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0698	0.9761
Onchocerca volvulus		0.0167	0.2403	0.9402
Echinococcus granulosus	serine:threonine protein kinase TAO1	0.0229	0.3393	0.3393
Trypanosoma brucei	Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative	0.0061	0.0715	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0075	0.0938	0.0938
Onchocerca volvulus		0.0022	0.0108	0.0419
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0034	0.0287	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0034	0.0287	1
Onchocerca volvulus		0.0022	0.0108	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0715	0.1502
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0034	0.0287	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0016	0.0001	0.0001
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0102	0.1367	0.2875
Schistosoma mansoni	protein kinase	0.0207	0.3037	0.3036
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0102	0.0101
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0698	0.9761
Echinococcus multilocularis	roundabout 2	0.0018	0.0033	0.0032
Echinococcus granulosus	roundabout 2	0.0018	0.0033	0.0033
Entamoeba histolytica	protein kinase, putative	0.0017	0.0026	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0715	0.1502
Onchocerca volvulus		0.0022	0.0108	0.0419
Onchocerca volvulus		0.0088	0.115	0.4497
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0022	0.0108	0.0107
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0152	0.217	0.4566
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0152	0.217	0.2169
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0073	0.0913	0.0913
Schistosoma mansoni	hypothetical protein	0.0061	0.0715	0.0714
Loa Loa (eye worm)	STE/STE20/MSN protein kinase	0.0146	0.2073	0.436
Brugia malayi	Temporarily assigned gene name protein 59	0.0061	0.0715	0.1502
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0034	0.0287	0.0286
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0054	0.0616	0.7679
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0715	0.1502
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0062	0.074	0.074
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0073	0.0913	0.0912
Brugia malayi	hypothetical protein	0.0022	0.0108	0.0225
Onchocerca volvulus		0.0022	0.0108	0.0419
Echinococcus granulosus	expressed conserved protein	0.0016	0.0001	0.0001
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0108	0.0225
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0698	0.9761
Echinococcus granulosus	tyrosine kinase	0.0058	0.0669	0.0669
Schistosoma mansoni	vav2	0.0017	0.0027	0.0026
Schistosoma mansoni	protein kinase	0.0062	0.074	0.0739
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0016	0.0001	0.0001
Schistosoma mansoni	serine/threonine protein kinase	0.017	0.2455	0.2454
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0016	0.0001	0.0001
Schistosoma mansoni	mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3	0.0061	0.0715	0.0714
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0058	0.0669	0.0667
Loa Loa (eye worm)	SRC-1	0.0073	0.0913	0.192
Echinococcus granulosus	SH2 motif	0.0016	0.0001	0.0001
Onchocerca volvulus	Tyrosine kinase homolog	0.0176	0.2556	1
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0108	0.0225
Brugia malayi	Hr1 repeat family protein	0.017	0.2455	0.5164
Echinococcus granulosus	growth factor receptor bound protein 2	0.0031	0.0246	0.0246
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0108	0.0225
Trichomonas vaginalis	alpha-glucosidase, putative	0.0034	0.0287	1
Echinococcus granulosus	lysosomal alpha glucosidase	0.0152	0.217	0.217
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0108	0.0225
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0034	0.0287	0.687
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0034	0.0287	0.5
Echinococcus granulosus	serine:threonine protein kinase N2	0.017	0.2455	0.2455
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0033	0.0067
Echinococcus granulosus	SHC transforming protein 3	0.0016	0.0001	0.0001
Schistosoma mansoni	mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3	0.0061	0.0715	0.0714
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0073	0.0913	0.0913
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0698	0.9761
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.074	0.0739
Brugia malayi	probable protein kinase	0.0207	0.3037	0.6391
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0058	0.0669	0.0669
Echinococcus granulosus	tyrosine kinase	0.0022	0.0108	0.0108
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0034	0.0287	0.0602
Schistosoma mansoni	rap gtpase-activating protein	0.0061	0.0715	0.0714
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0418	0.0877
Echinococcus multilocularis	c src tyrosine kinase	0.0038	0.0353	0.0352
Loa Loa (eye worm)	TK protein kinase	0.0058	0.0669	0.1405
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0073	0.0913	0.0912
Echinococcus granulosus	tyrosine protein kinase Srms	0.0022	0.0108	0.0108
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0108	0.0225
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0133	0.1868	0.1867
Echinococcus granulosus	Vam6:Vps39 protein	0.0061	0.0715	0.0715
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0034	0.0287	0.687
Schistosoma mansoni	tyrosine kinase	0.0038	0.0353	0.0352
Echinococcus granulosus	serine:threonine protein kinase mig 15	0.0205	0.3012	0.3012
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0698	0.9761
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0016	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0246	0.0515
Leishmania major	cathepsin L-like protease	0.006	0.0698	1
Schistosoma mansoni	vam6/vps39 related	0.0061	0.0715	0.0714
Schistosoma mansoni	tyrosine kinase	0.0183	0.2657	0.2657
Echinococcus multilocularis		0.0146	0.2073	0.2072
Echinococcus granulosus	tyrosine protein kinase HCK	0.0042	0.0418	0.0418
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0051	0.0562	0.0562
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0152	0.217	0.4566
Echinococcus granulosus	protein tyrosine kinase	0.0311	0.4694	0.4694
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0043	0.043	0.0902
Brugia malayi	Protein kinase domain containing protein	0.0314	0.4752	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0043	0.043	0.0429
Echinococcus granulosus	hypothetical protein	0.0016	0.0001	0.0001
Schistosoma mansoni	microtubule-associated protein tau	0.0644	1	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0022	0.0108	0.0108
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0188	0.2747	0.578
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0062	0.074	0.0739
Echinococcus multilocularis	microtubule associated protein 2	0.0644	1	1
Echinococcus multilocularis	tyrosine kinase	0.0022	0.0108	0.0107
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0062	0.074	0.0739
Entamoeba histolytica	protein kinase, putative	0.0042	0.0418	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0033	0.0067
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0017	0.0021	0.002
Brugia malayi	Variant SH3 domain containing protein	0.0031	0.0246	0.0515
Schistosoma mansoni	nck2/grb4	0.0031	0.0246	0.0245
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0108	0.0225
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.0669	0.0667
Loa Loa (eye worm)	STE/STE20/TAO protein kinase	0.0229	0.3393	0.7139
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0016	0.0001	0.0001
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0108	0.0225
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0073	0.0913	0.0913
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0698	0.9761
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0108	0.0225
Schistosoma mansoni	alpha-glucosidase	0.0131	0.1833	0.1832
Echinococcus granulosus	tensin	0.0016	0.0001	0.0001
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0073	0.0913	0.0912
Echinococcus multilocularis	GTPase activating Rap:RanGAP domain 3	0.0061	0.0715	0.0714
Brugia malayi	Sex muscle abnormal protein 5	0.0031	0.0246	0.0515
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0062	0.074	0.074
Brugia malayi	Protein kinase domain containing protein	0.0062	0.074	0.1555
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0038	0.0353	0.0352
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0272	0.4072	0.4072
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0043	0.043	0.043
Brugia malayi	Tyrosine-protein kinase abl-1	0.0154	0.2199	0.4626
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0156	0.2229	0.2228
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0108	0.0225
Brugia malayi	SH2 domain containing protein	0.0022	0.0108	0.0225
Echinococcus granulosus	neutral alpha glucosidase AB	0.0034	0.0287	0.0287
Schistosoma mansoni	tyrosine kinase	0.0073	0.0913	0.0912
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0058	0.0669	0.0667
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0034	0.0287	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0198	0.2902	0.2901
Echinococcus multilocularis	serine:threonine protein kinase TAO1	0.0229	0.3393	0.3392
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0034	0.0287	0.0602
Echinococcus granulosus	N chimaerin	0.0016	0.0001	0.0001
Trypanosoma cruzi	cruzipain precursor, putative	0.006	0.0698	0.9602
Loa Loa (eye worm)	thyroid receptor interactor	0.0102	0.1367	0.2875
Schistosoma mansoni	protein kinase	0.0146	0.2073	0.2072
Echinococcus granulosus	tyrosine protein kinase Blk	0.0058	0.0669	0.0669
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0016	0.0001	0.0001
Trypanosoma cruzi	cysteine peptidase, putative	0.006	0.0698	0.9602
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0188	0.2747	0.578
Echinococcus granulosus	GTPase activating Rap:RanGAP domain 3	0.0061	0.0715	0.0715
Schistosoma mansoni	tyrosine kinase	0.0256	0.3822	0.3821
Onchocerca volvulus		0.0017	0.002	0.0074
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0073	0.0913	0.0912
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0108	0.0225
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0051	0.0562	0.056
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0698	0.9761
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0062	0.074	0.074
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0043	0.043	0.0902
Schistosoma mansoni	serine/threonine protein kinase	0.0229	0.3393	0.3392
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.043	0.0429
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0698	0.9761
Echinococcus granulosus	signal transduction protein lnk realted	0.0016	0.0001	0.0001
Brugia malayi	Variant SH3 domain containing protein	0.0031	0.0246	0.0515
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0698	0.9761
Schistosoma mansoni	growth factor receptor-bound protein	0.0031	0.0246	0.0245
Brugia malayi	Variant SH3 domain containing protein	0.0017	0.0027	0.0055
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0017	0.0027	0.0055
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0073	0.0913	0.0912
Onchocerca volvulus		0.0022	0.0108	0.0419
Onchocerca volvulus		0.0022	0.0108	0.0419
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0108	0.0225
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0062	0.074	0.0739
Loa Loa (eye worm)	hypothetical protein	0.0205	0.3012	0.6338
Echinococcus granulosus	NCK adaptor protein	0.0031	0.0246	0.0246
Trypanosoma cruzi	Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative	0.0061	0.0715	1
Brugia malayi	Serine/threonine-protein kinase SULU	0.0229	0.3393	0.7139
Trypanosoma brucei	glucosidase, putative	0.0034	0.0287	0.3996
Leishmania major	cathepsin L-like protease	0.006	0.0698	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0034	0.0287	1
Schistosoma mansoni	alpha-glucosidase	0.0131	0.1833	0.1832
Schistosoma mansoni	growth factor receptor-bound protein	0.0031	0.0246	0.0245
Trichomonas vaginalis	alpha-glucosidase, putative	0.0034	0.0287	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0031	0.0246	0.0515
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.074	0.0739
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0698	0.9761
Echinococcus granulosus	SH2 domain containing protein 7	0.0016	0.0001	0.0001
Schistosoma mansoni	tyrosine kinase	0.0311	0.4694	0.4694
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0108	0.0225
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0073	0.0913	0.0912
Brugia malayi	hypothetical protein	0.0061	0.0715	0.1502
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0108	0.0225
Echinococcus multilocularis	tyrosine protein kinase shark	0.0022	0.0108	0.0107
Loa Loa (eye worm)	AGC/PKN protein kinase	0.017	0.2455	0.5164
Echinococcus granulosus	c src tyrosine kinase	0.0038	0.0353	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1373	0.2888
Trichomonas vaginalis	alpha-glucosidase, putative	0.0034	0.0287	1
Schistosoma mansoni	tyrosine kinase	0.0022	0.0108	0.0107
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0073	0.0913	0.0912
Brugia malayi	Tyrosine-protein kinase abl-1	0.0133	0.1868	0.3931
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0016	0.0001	0.0001
Loa Loa (eye worm)	STE/STE20/KHS protein kinase	0.0062	0.074	0.1555
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0016	0.0003	0.0003
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0022	0.0108	0.2568
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.043	0.0429
Echinococcus granulosus	protein kinase	0.0146	0.2073	0.2073
Entamoeba histolytica	hypothetical protein	0.0017	0.0021	0.0482
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0022	0.0108	0.0108
Brugia malayi	hypothetical protein	0.0229	0.3393	0.7139
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0698	0.9761
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0073	0.0913	0.0913
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0108	0.0225
Trypanosoma cruzi	cysteine peptidase, putative	0.006	0.0698	0.9602
Brugia malayi	SRC-1	0.0073	0.0913	0.192
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.043	0.0429
Entamoeba histolytica	protein kinase, putative	0.0016	0.0003	0.0037
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0016	0.0001	0.0001
Schistosoma mansoni	adapter molecule crk	0.0031	0.0246	0.0245
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0108	0.0225
Trypanosoma cruzi	Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative	0.0061	0.0715	1
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0017	0.0021	0.002
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0031	0.0246	0.0245
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0272	0.4072	0.4072
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0073	0.0913	0.0913
Entamoeba histolytica	protein kinase, putative	0.0016	0.0003	0.0037
Trichomonas vaginalis	alpha-glucosidase, putative	0.0034	0.0287	1
Schistosoma mansoni	alpha glucosidase	0.0034	0.0287	0.0286
Onchocerca volvulus		0.0061	0.0715	0.2794
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0043	0.043	0.043
Loa Loa (eye worm)	TK/ABL protein kinase	0.0272	0.4072	0.857
Loa Loa (eye worm)	TK/FAK protein kinase	0.0314	0.4752	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0031	0.0246	0.0515
Echinococcus multilocularis	protein tyrosine kinase	0.0311	0.4694	0.4694
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0017	0.0026	0.0603
Schistosoma mansoni	tyrosine kinase	0.0038	0.0353	0.0352
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0043	0.043	0.0429
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0073	0.0913	0.0912
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0198	0.2902	0.2902
Echinococcus granulosus	serine:threonine protein kinase N2	0.0156	0.2229	0.2229
Schistosoma mansoni	tyrosine kinase	0.0073	0.0913	0.0912
Echinococcus granulosus	SH2 motif	0.0016	0.0001	0.0001
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0003	0.0003
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0042	0.0418	0.0417
Leishmania major	cathepsin L-like protease	0.006	0.0698	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0027	0.0055

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (functional)	> 5.2	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: TAO1	ChEMBL.	No reference
Ki (functional)	> 5.2	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PTK2	ChEMBL.	No reference
Ki (functional)	> 5.2	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: BTK	ChEMBL.	No reference
Ki (functional)	> 5.2	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: FYN	ChEMBL.	No reference
Ki (functional)	> 5.3	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MINK	ChEMBL.	No reference
Ki (functional)	> 5.3	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PKN2	ChEMBL.	No reference
Ki (functional)	= 5.7	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: KDR	ChEMBL.	No reference
Ki (functional)	= 5.9	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAP4K4	ChEMBL.	No reference
Ki (functional)	= 6.3	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: LCK	ChEMBL.	No reference
Ki (functional)	= 6.3	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ABL1	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1992473

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1629381