Detailed information for compound 1648401

Basic information

Technical information
  • TDR Targets ID: 1648401
  • Name: (3S,6S,9S,12R)-9-[6-[(2S)-oxiran-2-yl]-6-oxoh exyl]-3,6-bis(phenylmethyl)-1,4,7,10-tetrazab icyclo[10.3.0]pentadecane-2,5,8,11-tetrone
  • MW: 588.694 | Formula: C33H40N4O6
  • H donors: 3 H acceptors: 5 LogP: 3.06 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C1N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N2[C@@H](C(=O)N[C@H]1CCCCCC(=O)[C@@H]1CO1)CCC2
  • InChi: 1S/C33H40N4O6/c38-28(29-21-43-29)17-9-3-8-15-24-30(39)35-25(19-22-11-4-1-5-12-22)31(40)36-26(20-23-13-6-2-7-14-23)33(42)37-18-10-16-27(37)32(41)34-24/h1-2,4-7,11-14,24-27,29H,3,8-10,15-21H2,(H,34,41)(H,35,39)(H,36,40)/t24-,25-,26-,27+,29-/m0/s1
  • InChiKey: LLOKIGWPNVSDGJ-AFBVCZJXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3S,6S,9S,12R)-9-[6-[(2S)-oxiran-2-yl]-6-oxo-hexyl]-3,6-bis(phenylmethyl)-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone
  • (3S,6S,9S,12R)-9-[6-[(2S)-2-oxiranyl]-6-oxohexyl]-3,6-bis(phenylmethyl)-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone
  • (3S,6S,9S,12R)-3,6-bis(benzyl)-9-[6-keto-6-[(2S)-oxiran-2-yl]hexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-diquinone
  • RF-1023-B
  • NChemBio.2007.16-comp3
  • Cyclo(.alpha.S,2S)-.alpha.-amino-.eta.-oxooxiraneoctanoyl- L-phenylalanyl-L-phenylalanyl-D-prolyl]
  • NSC700657
  • Trapoxin B
  • NCI60_036184

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Zea mays Histone deacetylase HD2 Starlite/ChEMBL References
Homo sapiens histone deacetylase 8 References
Homo sapiens histone deacetylase 9 Starlite/ChEMBL References
Homo sapiens histone deacetylase 2 References
Homo sapiens histone deacetylase 1 References
Homo sapiens histone deacetylase 3 References
Homo sapiens histone deacetylase 10 References
Homo sapiens histone deacetylase 4 References
Homo sapiens histone deacetylase 5 References
Homo sapiens histone deacetylase 6 References
Homo sapiens histone deacetylase 7 References
Mus musculus histone deacetylase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum histone deacetylase 2 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Neospora caninum hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii Histone deacetylase family, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi histone deacetylase 3 (HD3) Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium berghei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum ko:K01463 Hdac3 [EC:3.5.1.-], putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum histone deacetylase HDA2/Rpd3p Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase hda2 Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Entamoeba histolytica histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi histone deacetylase 1 (HD1) Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum IPR000286,Histone deacetylase superfamily;IPR013838,Beta tubulin, autoregulation binding site,domain-containing Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase 7A Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei gambiense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium vivax histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Babesia bovis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Giardia lamblia Histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Babesia bovis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC3 Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei gambiense histone deacetylase 1,histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase 3 Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum ko:K06067 histone deacetylase 1/2, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC2 Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum RPD3/HD1 histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium berghei histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC1 Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi histone deacetylase, putative histone deacetylase 3 428 aa 374 aa 30.5 %
Trypanosoma brucei histone deacetylase 2 histone deacetylase 2 488 aa 427 aa 29.0 %
Plasmodium falciparum histone deacetylase 1 histone deacetylase 8 286 aa 241 aa 44.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor 0.0089 0.0321 0.0317
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0059 0.0188 0.0963
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0189 0.0761 0.0824
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Brugia malayi histone deacetylase 11 0.0197 0.0797 0.4139
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0059 0.0188 0.0185
Schistosoma mansoni steroid hormone receptor ad4bp 0.0189 0.0761 0.0757
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0021 0.0017
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0417 0.1765 0.8381
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0434 0.184 0.9581
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0021 0.0018
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.003 0.0404
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0186 0.0747 0.3878
Schistosoma mansoni hypothetical protein 0.0164 0.0651 0.0647
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0021 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0072 0.0074
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0262 0.1081 0.1172
Loa Loa (eye worm) glutaminase 2 0.0265 0.1094 0.5688
Onchocerca volvulus 0.0494 0.2104 1
Plasmodium vivax histone deacetylase, putative 0.0452 0.192 1
Echinococcus multilocularis glycine receptor subunit beta 0.0059 0.0188 0.0201
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Echinococcus multilocularis tumor protein p63 0.033 0.1383 0.1501
Trypanosoma brucei glutaminyl cyclase, putative 0.0042 0.0111 0.0561
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0185 0.0742 0.0804
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0185 0.0742 0.3852
Echinococcus granulosus histone deacetylase 6 0.0452 0.192 0.2086
Brugia malayi Matrixin family protein 0.0114 0.0431 0.223
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0021 0.0077
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Brugia malayi Matrixin family protein 0.0114 0.0431 0.223
Brugia malayi nuclear receptor NHR-88 0.0189 0.0761 0.3948
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0189 0.0761 0.0824
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0037 0.0036
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0042 0.0111 0.0117
Brugia malayi nuclear hormone receptor family member nhr-6 0.0089 0.0321 0.1653
Echinococcus granulosus histone deacetylase 0.0452 0.192 0.2086
Loa Loa (eye worm) hypothetical protein 0.0234 0.0956 0.4969
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0089 0.0321 0.0345
Echinococcus multilocularis FTZ F1 alpha 0.0189 0.0761 0.0824
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0187 0.1677
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0416 0.1758 0.1909
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Echinococcus granulosus flap endonuclease 1 0.0028 0.0053 0.0054
Schistosoma mansoni hypothetical protein 0.0071 0.0238 0.0235
Brugia malayi nuclear hormone receptor 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.0086 0.0307 0.158
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Echinococcus granulosus microtubule associated protein 2 0.2103 0.919 1
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0042 0.0111 0.15
Onchocerca volvulus 0.0048 0.0141 0.0544
Entamoeba histolytica hypothetical protein 0.0036 0.0085 0.0446
Brugia malayi ecdysone receptor 0.0089 0.0321 0.1653
Schistosoma mansoni histone deacetylase 0.0417 0.1765 0.1762
Toxoplasma gondii hypothetical protein 0.0042 0.0111 0.0561
Echinococcus multilocularis histone deacetylase 0.0452 0.192 0.2086
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Echinococcus granulosus geminin 0.0164 0.0651 0.0704
Brugia malayi TAR-binding protein 0.0123 0.0471 0.2436
Toxoplasma gondii histone deacetylase HDAC5 0.0197 0.0797 0.4139
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0021 0.0088
Leishmania major DNA polymerase eta, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.01 0.0368 0.1899
Loa Loa (eye worm) steroid hormone receptor 0.0189 0.0761 0.3948
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0089 0.0321 0.0345
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0185 0.0742 0.0804
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) nuclear hormone receptor 0.0089 0.0321 0.1653
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0185 0.0742 0.4181
Loa Loa (eye worm) leucyl aminopeptidase 0.0042 0.0111 0.0561
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0007 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0037 0.0141
Schistosoma mansoni coup transcription factor 0.0189 0.0761 0.0757
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0186 0.0747 0.0809
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0139 0.0541 0.7289
Brugia malayi AMP-binding enzyme family protein 0.0023 0.003 0.0136
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0158 0.0802
Echinococcus multilocularis neuropeptide receptor A26 0.0517 0.2206 0.2397
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0007 0.0017
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0185 0.0742 0.0804
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0059 0.0188 0.0963
Entamoeba histolytica hypothetical protein 0.0036 0.0085 0.0446
Leishmania major histone deacetylase, putative 0.0452 0.192 1
Onchocerca volvulus 0.0036 0.0088 0.0292
Giardia lamblia DINP protein human, muc B family 0.0021 0.0021 0.0077
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.0048 0.0141 0.0714
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0053 0.0257
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0187 0.0199
Leishmania major hypothetical protein, conserved 0.0052 0.0158 0.0802
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0158 0.0802
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0042 0.0111 0.0117
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0059 0.0188 0.0201
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0185 0.0742 0.3504
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0007 0.0017
Echinococcus multilocularis nuclear receptor nhr 48 0.0089 0.0321 0.0345
Onchocerca volvulus Fxna peptidase homolog 0.0042 0.0111 0.0402
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0007 0.0017
Entamoeba histolytica protein kinase domain containing protein 0.0087 0.0311 0.1731
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0053 0.0257
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Echinococcus granulosus Nuclear hormone receptor HR96 0.0089 0.0321 0.0345
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0123 0.0471 0.2436
Echinococcus granulosus tar DNA binding protein 0.0123 0.0471 0.0508
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0023 0.0028 0.0026
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0087 0.0311 0.1604
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0021 0.0018
Onchocerca volvulus Glutaminyl cyclase homolog 0.0262 0.1081 0.507
Brugia malayi Peptidase family M28 containing protein 0.0262 0.1081 0.5618
Loa Loa (eye worm) hypothetical protein 0.0197 0.0797 0.4139
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0189 0.0761 0.0824
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0059 0.0188 0.0963
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0085 0.0089
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0185 0.0742 0.3504
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0059 0.0188 0.0201
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0215 0.1101
Trypanosoma cruzi histone deacetylase, putative 0.0452 0.192 1
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0042 0.0111 0.0983
Entamoeba histolytica histone deacetylase, putative 0.0417 0.1765 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0089 0.0321 0.0345
Entamoeba histolytica protein kinase, putative 0.0087 0.0311 0.1731
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Schistosoma mansoni nuclear hormone receptor 0.0089 0.0321 0.0317
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.003 0.0237
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0094 0.0098
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0007 0.0018
Echinococcus granulosus glycine receptor subunit beta 0.0059 0.0188 0.0201
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0095 0.0099
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Echinococcus multilocularis dual specificity 0.0087 0.0311 0.0335
Loa Loa (eye worm) hypothetical protein 0.0163 0.0646 0.3352
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Brugia malayi Histone deacetylase 1 0.0417 0.1765 0.9188
Brugia malayi excitatory GABA receptor EXP-1A 0.0059 0.0188 0.0963
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0215 0.1101
Schistosoma mansoni nuclear receptor nhr-48 0.0089 0.0321 0.0317
Trypanosoma cruzi histone deacetylase 1, putative 0.0417 0.1765 0.9188
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0072 0.0074
Echinococcus multilocularis microtubule associated protein 2 0.2103 0.919 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0007 0.0017
Echinococcus multilocularis dna polymerase eta 0.0021 0.0021 0.0018
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0215 0.1101
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0053 0.0257
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0072 0.0354
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0215 0.023
Schistosoma mansoni flap endonuclease-1 0.0026 0.0041 0.0037
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0059 0.0188 0.0201
Loa Loa (eye worm) hypothetical protein 0.0114 0.0431 0.223
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0185 0.0742 0.3504
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0189 0.0761 0.3948
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0185 0.0742 1
Echinococcus multilocularis histone deacetylase 7 0.0452 0.192 0.2086
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0007 0.0017
Trypanosoma brucei histone deacetylase 4 0.0452 0.192 1
Plasmodium vivax histone deacetylase, putative 0.0197 0.0797 0.4139
Brugia malayi hypothetical protein 0.0148 0.0578 0.2998
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0187 0.1677
Schistosoma mansoni acetylcholine receptor-related 0.0023 0.0028 0.0024
Brugia malayi Histone deacetylase family protein 0.0452 0.192 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0059 0.0188 0.0201
Onchocerca volvulus 0.0059 0.0188 0.0773
Schistosoma mansoni nAChR subunit 0.0023 0.0028 0.0024
Echinococcus multilocularis histone deacetylase 1 0.0417 0.1765 0.1917
Echinococcus multilocularis muscleblind protein 1 0.0163 0.0646 0.0699
Schistosoma mansoni histone deacetylase hda2 0.0197 0.0797 0.0793
Loa Loa (eye worm) BRM protein 0.0047 0.0134 0.068
Loa Loa (eye worm) hypothetical protein 0.0255 0.1051 0.5465
Plasmodium falciparum glutathione reductase 0.0037 0.0092 0.0462
Brugia malayi Matrixin family protein 0.0114 0.0431 0.223
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0345 0.6164
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0028 0.0125
Onchocerca volvulus 0.0089 0.0321 0.141
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0092
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.003 0.013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0072 0.0074
Trypanosoma cruzi histone deacetylase, putative 0.0452 0.192 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0023 0.0028 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.0747 0.0744
Onchocerca volvulus 0.0059 0.0188 0.0773
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0085 0.0082
Echinococcus multilocularis tar DNA binding protein 0.0123 0.0471 0.0508
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0136
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Schistosoma mansoni histone deacetylase 0.0417 0.1765 0.1762
Trypanosoma cruzi histone deacetylase, putative 0.0452 0.192 1
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Echinococcus granulosus ecdysone induced protein 78C 0.0189 0.0761 0.0824
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Echinococcus multilocularis nAChR subunit 0.0036 0.0088 0.0092
Mycobacterium tuberculosis Probable reductase 0.0085 0.0303 0.4084
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0021 0.0065
Trypanosoma brucei unspecified product 0.0021 0.0021 0.0088
Trypanosoma cruzi histone deacetylase 1, putative 0.0417 0.1765 0.9188
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Brugia malayi Hemopexin family protein 0.0162 0.0641 0.3327
Echinococcus multilocularis histone deacetylase 6 0.0452 0.192 0.2086
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0042 0.0111 0.0117
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.003 0.0237
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0062 0.0202 0.1035
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0561
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.0185 0.0742 0.3852
Leishmania major trypanothione reductase 0.0037 0.0092 0.0462
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0189 0.0761 0.3948
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0007 0.0003
Brugia malayi Nuclear hormone receptor E75 0.0089 0.0321 0.1653
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0059 0.0188 0.0963
Brugia malayi conserved hypotetical protein 0.0089 0.0321 0.1653
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0189 0.0761 0.3948
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0215 0.1101
Loa Loa (eye worm) LGC-31 protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0263 0.1084 0.5636
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0187 0.0955
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.0898 0.388 0.5
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0185 0.0742 0.0738
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0187 0.1677
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0007 0.0004
Echinococcus granulosus neuropeptide s receptor 0.0517 0.2206 0.2397
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0561
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0215 0.1182
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0053 0.0054
Echinococcus granulosus histone deacetylase 6 0.0452 0.192 0.2086
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0202 0.0216
Schistosoma mansoni hypothetical protein 0.0033 0.0072 0.0068
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0021 0.0017
Brugia malayi Pre-SET motif family protein 0.0062 0.0202 0.1035
Brugia malayi Thioredoxin reductase 0.0037 0.0092 0.0462
Echinococcus granulosus nAChR subunit 0.0036 0.0088 0.0092
Plasmodium falciparum histone deacetylase 1 0.0417 0.1765 0.9188
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Schistosoma mansoni zinc finger protein 0.0089 0.0321 0.0317
Trypanosoma cruzi histone deacetylase, putative 0.0197 0.0797 0.4139
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.1059 0.5505
Loa Loa (eye worm) hypothetical protein 0.0114 0.0431 0.223
Brugia malayi nuclear receptor RXR 0.0089 0.0321 0.1653
Schistosoma mansoni nuclear receptor 0.0089 0.0321 0.0317
Leishmania major histone deacetylase, putative 0.0417 0.1765 0.9188
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Mycobacterium tuberculosis Conserved protein 0.0042 0.0111 0.15
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0053 0.0219
Loa Loa (eye worm) histone deacetylase 0.0452 0.192 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0189 0.0761 0.0824
Brugia malayi histone deacetylase 1 (HD1) 0.0417 0.1765 0.9188
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) histone deacetylase 11 0.0197 0.0797 0.4139
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Plasmodium vivax histone deacetylase 2, putative 0.0452 0.192 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0089 0.0321 0.141
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0092 0.0462
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0089 0.0321 0.1653
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0561
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0021 0.0279
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.0188 0.0185
Brugia malayi hypothetical protein 0.01 0.0368 0.1899
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0303 0.4084
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Schistosoma mansoni hypothetical protein 0.0033 0.0072 0.0068
Treponema pallidum ATP-dependent RNA helicase 0.0185 0.0742 0.5
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0042 0.0111 0.0107
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0059 0.0188 0.0201
Echinococcus multilocularis neuropeptide s receptor 0.0517 0.2206 0.2397
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0192 0.0205
Loa Loa (eye worm) matrixin family protein 0.0276 0.1145 0.5953
Loa Loa (eye worm) hypothetical protein 0.0163 0.0646 0.3352
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0059 0.0188 0.0185
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0023 0.0028 0.0026
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0031 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Onchocerca volvulus 0.0059 0.0188 0.0773
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi hypothetical protein 0.0052 0.0158 0.0802
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0354
Onchocerca volvulus 0.0189 0.0761 0.3529
Schistosoma mansoni histone deacetylase hda2 0.046 0.1953 0.195
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0189 0.0761 0.3948
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0059 0.0188 0.0201
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Schistosoma mansoni nicalin (M28 family) 0.0042 0.0111 0.0107
Echinococcus multilocularis histone deacetylase 3 0.0417 0.1765 0.1917
Brugia malayi steroid hormone receptor 0.0189 0.0761 0.3948
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Onchocerca volvulus Protein ultraspiracle homolog 0.0189 0.0761 0.3529
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0004 0.0056
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.01 0.0368 0.0396
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0187 0.2519
Schistosoma mansoni nuclear receptor 0.0089 0.0321 0.0317
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0007 0.0017
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0053 0.0262
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0238 0.1224
Onchocerca volvulus 0.0059 0.0188 0.0773
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0189 0.0761 0.3948
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0087 0.0311 0.1604
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0502 0.2599
Loa Loa (eye worm) nuclear receptor NHR-67 0.0089 0.0321 0.1653
Echinococcus multilocularis histone deacetylase 6 0.046 0.1953 0.2122
Brugia malayi hypothetical protein 0.0089 0.0321 0.1653
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0416 0.1758 0.1909
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) histone deacetylase 3 0.0417 0.1765 0.9188
Brugia malayi Nuclear hormone receptor-like 1 0.01 0.0368 0.1899
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Loa Loa (eye worm) histone deacetylase 7A 0.0452 0.192 1
Mycobacterium ulcerans glutaminase 0.0265 0.1094 1
Leishmania major histone deacetylase, putative 0.0417 0.1765 0.9188
Loa Loa (eye worm) glutaminase 0.0265 0.1094 0.5688
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0031 0.0029
Trypanosoma brucei histone deacetylase 2 0.0197 0.0797 0.4139
Schistosoma mansoni kinase 0.0095 0.0345 0.0341
Brugia malayi nuclear receptor NHR-88 0.0089 0.0321 0.1653
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0186 0.0747 0.0809
Brugia malayi Muscleblind-like protein 0.0163 0.0646 0.3352
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0021 0.0088
Echinococcus multilocularis histone deacetylase 8 0.0197 0.0797 0.0863
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0382 0.1974
Brugia malayi glutaminase DH11.1 0.0265 0.1094 0.5688
Onchocerca volvulus Bile acid receptor homolog 0.0189 0.0761 0.3529
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0037 0.0036
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0202 0.0216
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0189 0.0761 0.0757
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0023 0.0028 0.0125
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0141 0.0137
Echinococcus multilocularis thyroid hormone receptor alpha 0.0189 0.0761 0.0824
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0189 0.0761 0.0757
Loa Loa (eye worm) hypothetical protein 0.0103 0.0382 0.1974
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0185 0.0742 0.3439
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0036 0.0088 0.0441
Plasmodium falciparum eukaryotic initiation factor 4A 0.0185 0.0742 0.3852
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0059 0.0188 0.0201
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.003 0.0404
Onchocerca volvulus Histone deacetylase 10 homolog 0.0197 0.0797 0.3704
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0345 0.4648
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0021 0.0279
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Schistosoma mansoni neurotransmitter gated ion channel 0.0036 0.0088 0.0085
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Echinococcus granulosus FTZ F1 alpha 0.0189 0.0761 0.0824
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0021 0.0088
Brugia malayi Matrixin family protein 0.0276 0.1145 0.5953
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0023 0.0028 0.0125
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0189 0.0761 0.0824
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Onchocerca volvulus 0.0148 0.0578 0.2651
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Onchocerca volvulus Matrix metalloproteinase homolog 0.0253 0.1044 0.4894
Schistosoma mansoni Fxna peptidase (M28 family) 0.0042 0.0111 0.0107
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0158 0.0802
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Loa Loa (eye worm) BRM protein 0.0038 0.0095 0.0475
Echinococcus granulosus global transcription activator snf2l2 0.0073 0.0251 0.0269
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0185 0.0742 0.3852
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Brugia malayi Cation transporter family protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) acetylcholine receptor protein 0.0023 0.0028 0.0125
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Schistosoma mansoni RAR-like nuclear receptor 0.0189 0.0761 0.0757
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0417 0.1765 0.8381
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0059 0.0188 0.0963
Loa Loa (eye worm) DR-78 0.0089 0.0321 0.1653
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0189 0.0761 0.0757
Brugia malayi Histone deacetylase family protein 0.0452 0.192 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0007 0.0017
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0187 0.0183
Schistosoma mansoni thyroid hormone receptor 0.0189 0.0761 0.0757
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.067 0.3092
Brugia malayi nuclear hormone receptor 0.0089 0.0321 0.1653
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0037 0.0171
Giardia lamblia Kinase, PLK 0.0186 0.0747 0.421
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.071 0.3351
Brugia malayi glutathione reductase 0.0037 0.0092 0.0462
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.0262 0.1081 0.5618
Schistosoma mansoni hypothetical protein 0.0033 0.0072 0.0068
Echinococcus granulosus dna polymerase kappa 0.0021 0.0021 0.0018
Echinococcus granulosus dna polymerase eta 0.0021 0.0021 0.0018
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0189 0.0761 0.0824
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0186 0.0747 0.3878
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0059 0.0188 0.0201
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0087 0.0311 0.1604
Echinococcus granulosus GPCR family 2 0.0033 0.0072 0.0074
Onchocerca volvulus 0.0023 0.003 0.001
Brugia malayi Protein kinase domain containing protein 0.0087 0.0311 0.1604
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0042 0.0111 0.0107
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0334 0.1561
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0053 0.0257
Brugia malayi ecdysteroid receptor 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0215 0.1101
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Trypanosoma brucei histone deacetylase 3 0.0452 0.192 1
Brugia malayi Cation transporter family protein 0.0059 0.0188 0.0963
Brugia malayi hypothetical protein 0.0089 0.0321 0.1653
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0189 0.0761 0.3948
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0059 0.0188 0.0201
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0189 0.0761 0.0824
Schistosoma mansoni nuclear hormone receptor 0.0189 0.0761 0.0757
Loa Loa (eye worm) hypothetical protein 0.0086 0.0307 0.158
Plasmodium vivax histone deacetylase 1, putative 0.0417 0.1765 0.9188
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0042 0.0111 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0189 0.0761 0.3948
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0185 0.0742 0.4181
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0185 0.0742 0.0738
Onchocerca volvulus Fxna peptidase homolog 0.0042 0.0111 0.0402
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0111 0.0497
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0036 0.0088 0.0441
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.003 0.0237
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0303 0.4084
Onchocerca volvulus Matrilysin homolog 0.0253 0.1044 0.4894
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0189 0.0761 0.3948
Onchocerca volvulus 0.0162 0.0641 0.2955
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0059 0.0188 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) glutathione reductase 0.0037 0.0092 0.0462
Onchocerca volvulus Serine\/threonine kinase homolog 0.0186 0.0747 0.3464
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.071 0.3351
Echinococcus granulosus muscleblind protein 0.0163 0.0646 0.0699
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0189 0.0761 0.0824
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0072 0.0074
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0092 0.1245
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0059 0.0188 0.0201
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Brugia malayi RNA recognition motif domain containing protein 0.0123 0.0471 0.2436
Loa Loa (eye worm) matrixin family protein 0.0253 0.1044 0.5428
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0036 0.0088 0.0085
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.01 0.0368 0.0396
Entamoeba histolytica hypothetical protein 0.0036 0.0085 0.0446
Trypanosoma cruzi polo-like protein kinase, putative 0.0186 0.0747 0.3878
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0059 0.0188 0.0963
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0139 0.0541 0.2802
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0053 0.0262
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.003 0.013
Brugia malayi Pre-SET motif family protein 0.0434 0.184 0.9581
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0007 0.0017
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Schistosoma mansoni glutaminase 0.0265 0.1094 0.1091
Echinococcus multilocularis GPCR, family 2 0.0033 0.0072 0.0074
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0089 0.0321 0.141
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0059 0.0188 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0189 0.0761 0.3948
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0108 0.0404 0.04
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0202 0.0198
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Onchocerca volvulus 0.0059 0.0188 0.0773
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0017
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0158 0.0802
Brugia malayi leucyl aminopeptidase 0.0042 0.0111 0.0561
Plasmodium vivax RNA helicase-1, putative 0.0185 0.0742 0.3852
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0089 0.0321 0.0345
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0345 0.4648
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0092 0.0462
Brugia malayi BRM protein 0.0073 0.0251 0.1289
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0262 0.1081 0.1077
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0502 0.2599
Loa Loa (eye worm) RNA binding protein 0.0123 0.0471 0.2436
Plasmodium falciparum histone deacetylase 2 0.0452 0.192 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0417 0.1765 0.8381
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0185 0.0742 0.3852
Brugia malayi Nuclear hormone receptor-like 1 0.01 0.0368 0.1899
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0085 0.0089
Loa Loa (eye worm) TAR-binding protein 0.0123 0.0471 0.2436
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0023 0.0028 0.0026
Schistosoma mansoni microtubule-associated protein tau 0.2103 0.919 0.919
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Schistosoma mansoni histone deacetylase 4 5 0.0452 0.192 0.1917
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0004 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0189 0.0761 0.3948
Loa Loa (eye worm) ACC-1 protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi Cation transporter family protein 0.0059 0.0188 0.0963
Plasmodium falciparum thioredoxin reductase 0.0037 0.0092 0.0462
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0136
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Echinococcus granulosus histone deacetylase 6 0.046 0.1953 0.2122
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0007 0.0003
Echinococcus granulosus thyroid hormone receptor alpha 0.0089 0.0321 0.0345
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0202 0.0198
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Echinococcus granulosus dual specificity 0.0087 0.0311 0.0335
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Trypanosoma brucei polo-like protein kinase 0.0186 0.0747 0.3878
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.003 0.0136
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0021 0.0152
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0187 0.0183
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0059 0.0188 0.0963
Schistosoma mansoni helicase 0.0073 0.0251 0.0247
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Onchocerca volvulus Matrilysin homolog 0.0114 0.0431 0.1942
Trypanosoma brucei histone deacetylase 1 0.0417 0.1765 0.9188
Echinococcus multilocularis ecdysone induced protein 78C 0.0189 0.0761 0.0824
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Schistosoma mansoni hypothetical protein 0.0036 0.0085 0.0082
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0037 0.0171
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.003 0.0237
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0053 0.0257
Brugia malayi orphan nuclear receptor NR2E1 0.0089 0.0321 0.1653
Echinococcus granulosus neuropeptide receptor A26 0.0517 0.2206 0.2397
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0334 0.1561
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0158 0.0802
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0158 0.0802
Leishmania major eukaryotic initiation factor 4a, putative 0.0185 0.0742 0.3852
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0262 0.1081 0.1172
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0059 0.0188 0.0201
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0215 0.1101
Schistosoma mansoni DNA polymerase eta 0.0021 0.0021 0.0017
Echinococcus granulosus glycine receptor subunit beta 0.0059 0.0188 0.0201
Loa Loa (eye worm) matrix metalloproteinase 0.0114 0.0431 0.223
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0189 0.0761 0.3948
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0092 0.0462
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0036 0.0088 0.0441
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.003 0.0237
Schistosoma mansoni histone deacetylase 1 2 3 0.0197 0.0797 0.0793
Onchocerca volvulus 0.0036 0.0088 0.0292
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0028 0.0125
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.0088
Brugia malayi Nuclear hormone receptor E75 0.0089 0.0321 0.1653
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0037 0.0171
Giardia lamblia Histone deacetylase 0.0417 0.1765 1
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0189 0.0761 0.0824
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Schistosoma mansoni thyroid hormone receptor 0.0189 0.0761 0.0757
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0036 0.0088 0.0441
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.1059 0.5505
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0189 0.0761 0.0824
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0023 0.0028 0.0026
Plasmodium vivax SET domain protein, putative 0.0062 0.0202 0.1035
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0028 0.0125
Brugia malayi Nuclear hormone receptor-like 1 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Toxoplasma gondii histone deacetylase HDAC3 0.0417 0.1765 0.9188
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0042 0.0111 0.0117
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0059 0.0188 0.0963
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0037 0.0171
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0037 0.0033
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0296 0.1233 0.6413
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0036 0.0088 0.0085
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.003 0.013
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0059 0.0188 0.0201
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0189 0.0761 0.3948
Schistosoma mansoni hypothetical protein 0.0164 0.0651 0.0647
Plasmodium falciparum histone deacetylase, putative 0.0452 0.192 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0021 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0004 0.5
Brugia malayi MH2 domain containing protein 0.013 0.0502 0.2599
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0189 0.0761 0.3948
Brugia malayi FXNA 0.0042 0.0111 0.0561
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0059 0.0188 0.0201
Brugia malayi histone deacetylase 3 (HD3) 0.0417 0.1765 0.9188
Onchocerca volvulus 0.0059 0.0188 0.0773
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0021 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0189 0.0761 0.3948
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0139 0.0541 0.2802
Echinococcus granulosus histone deacetylase 1 0.0417 0.1765 0.1917
Echinococcus multilocularis glycine receptor subunit beta 0.0059 0.0188 0.0201
Echinococcus granulosus histone deacetylase 3 0.0417 0.1765 0.1917
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.01 0.0368 0.0364
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0072 0.0354
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0187 0.0955
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0303 0.4084
Loa Loa (eye worm) hypothetical protein 0.0148 0.0578 0.2998
Schistosoma mansoni nAChR subunit 0.0023 0.0028 0.0024
Loa Loa (eye worm) hypothetical protein 0.0417 0.1765 0.9188
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0072 0.0354
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Brugia malayi eukaryotic initiation factor 4A 0.0185 0.0742 0.3852
Mycobacterium leprae PROBABLE HYDROLASE 0.0139 0.0541 1
Entamoeba histolytica hypothetical protein 0.0036 0.0088 0.0463
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0017
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.0188 0.0185
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0094 0.0098
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0007 0.0017
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0017
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0059 0.0188 0.0963
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0089 0.0321 0.0345
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Echinococcus granulosus nuclear receptor nhr 48 0.0089 0.0321 0.0345
Trichomonas vaginalis set domain proteins, putative 0.0494 0.2104 1
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0023 0.0028 0.0125
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0095 0.0099
Echinococcus multilocularis global transcription activator snf2l2 0.0073 0.0251 0.0269
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Onchocerca volvulus 0.0062 0.0202 0.0839
Onchocerca volvulus Putative nachr subunit 0.0059 0.0188 0.0773
Trypanosoma cruzi glutaminyl cyclase, putative 0.0042 0.0111 0.0561
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0021 0.0092
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.003 0.0136
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0382 0.1974
Echinococcus granulosus eukaryotic initiation factor 4A 0.0185 0.0742 0.0804
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0089 0.0321 0.0345
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0089 0.0321 0.1653
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0561
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0021 0.0088
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0189 0.0761 0.0824
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Brugia malayi RNA binding protein 0.0123 0.0471 0.2436
Brugia malayi AMP-binding enzyme family protein 0.0023 0.003 0.0136
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0059 0.0188 0.0963
Leishmania major histone deacetylase, putative 0.0452 0.192 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0111 0.0497
Echinococcus multilocularis geminin 0.0164 0.0651 0.0704
Brugia malayi Flap endonuclease-1 0.0028 0.0053 0.0257
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Echinococcus multilocularis nAChR subunit 0.0059 0.0188 0.0201
Toxoplasma gondii thioredoxin reductase 0.0037 0.0092 0.0462
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0189 0.0761 0.0757
Onchocerca volvulus Fxna peptidase homolog 0.0042 0.0111 0.0402
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.0188 0.0185
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Trypanosoma brucei trypanothione reductase 0.0037 0.0092 0.0462
Toxoplasma gondii histone deacetylase HDAC4 0.0197 0.0797 0.4139
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0087 0.0311 0.1604
Brugia malayi nuclear receptor RXR 0.01 0.0368 0.1899
Schistosoma mansoni retinoic acid receptor RXR 0.0189 0.0761 0.0757
Schistosoma mansoni neurotransmitter gated ion channel 0.0023 0.0028 0.0024
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0189 0.0761 0.3529
Onchocerca volvulus 0.0089 0.0321 0.141
Echinococcus multilocularis muscleblind protein 0.0163 0.0646 0.0699
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0158 0.0802
Brugia malayi AMP-binding enzyme family protein 0.0023 0.003 0.0136
Plasmodium vivax glutathione reductase, putative 0.0037 0.0092 0.0462
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0007 0.0004
Echinococcus granulosus histone deacetylase 7 0.0452 0.192 0.2086
Echinococcus granulosus Nuclear hormone receptor HR96 0.0089 0.0321 0.0345
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0007 0.0004
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.003 0.0237
Echinococcus granulosus nAChR subunit 0.0059 0.0188 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0189 0.0761 0.3948
Schistosoma mansoni hypothetical protein 0.0023 0.0031 0.0027
Schistosoma mansoni acetylcholine receptor subunit beta 0.0023 0.0028 0.0024
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0189 0.0761 0.0824
Loa Loa (eye worm) hypothetical protein 0.0063 0.0204 0.1043
Schistosoma mansoni histone deacetylase 4 5 0.0452 0.192 0.1917
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.0042 0.0111 0.0497
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Leishmania major hypothetical protein, conserved 0.0042 0.0111 0.0561
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0189 0.0761 0.3948
Toxoplasma gondii peptidase, M28 family protein 0.0042 0.0111 0.0561
Schistosoma mansoni polycystin 1-related 0.0079 0.0275 0.0272
Mycobacterium ulcerans hydrolase 0.0139 0.0541 0.4924
Trypanosoma cruzi histone deacetylase, putative 0.0197 0.0797 0.4139
Brugia malayi photoreceptor-specific nuclear receptor 0.0189 0.0761 0.3948
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0215 0.0211
Entamoeba histolytica serine/threonine protein kinase, putative 0.0186 0.0747 0.421
Brugia malayi hypothetical protein 0.0034 0.0076 0.0377
Schistosoma mansoni retinoid-x-receptor (RXR) 0.01 0.0368 0.0364
Onchocerca volvulus 0.0042 0.0111 0.0402
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0087 0.0311 0.1604
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0311 0.0308
Brugia malayi hypothetical protein 0.01 0.0368 0.1899
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0053 0.0257
Brugia malayi nuclear receptor NHR-67 0.0089 0.0321 0.1653
Entamoeba histolytica hypothetical protein 0.0036 0.0085 0.0446
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0007 0.0017
Entamoeba histolytica protein kinase, putative 0.0087 0.0311 0.1731
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0088
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0023 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0202 0.0198
Loa Loa (eye worm) hypothetical protein 0.0071 0.0238 0.1224
Schistosoma mansoni hypothetical protein 0.0033 0.0072 0.0068
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0189 0.0761 0.3948
Mycobacterium ulcerans hypothetical protein 0.0023 0.003 0.0237
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0007 0.0004
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0202 0.1035
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0089 0.0321 0.0317
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0136
Brugia malayi serine/threonine-protein kinase plk-2 0.0186 0.0747 0.3878
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0007 0.0017
Leishmania major DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Echinococcus multilocularis histone deacetylase 6 0.0452 0.192 0.2086
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.003 0.0136
Brugia malayi hypothetical protein 0.0036 0.0085 0.0426
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0189 0.0761 0.0757
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0111 0.0497
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0187 0.0199
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0114 0.0431 0.0427
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0158 0.0802
Loa Loa (eye worm) hypothetical protein 0.0125 0.048 0.2486
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0059 0.0188 0.0963
Loa Loa (eye worm) GABA receptor subunit 0.0036 0.0088 0.0441
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.0088
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0189 0.0761 0.0824
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0303 0.5345
Toxoplasma gondii histone deacetylase HDAC1 0.0452 0.192 1
Loa Loa (eye worm) histone deacetylase 1 0.0417 0.1765 0.9188
Plasmodium falciparum flap endonuclease 1 0.0028 0.0053 0.0257
Echinococcus granulosus tumor protein p63 0.033 0.1383 0.1501
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.003 0.0237
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Brugia malayi nicalin 0.0042 0.0111 0.0561
Trypanosoma brucei histone deacetylase, putative 0.0452 0.192 1
Leishmania major eukaryotic initiation factor 4a, putative 0.0185 0.0742 0.3852
Echinococcus granulosus histone deacetylase 8 0.0197 0.0797 0.0863
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0189 0.0761 0.3948
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0021 0.0088
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Trichomonas vaginalis glutaminase, putative 0.0265 0.1094 0.5183
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0382 0.1974
Onchocerca volvulus 0.0114 0.0431 0.1942
Brugia malayi Matrixin family protein 0.0114 0.0431 0.223
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0004 0.0002
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0185 0.0742 0.3852
Schistosoma mansoni neurotransmitter gated ion channel 0.0023 0.0028 0.0024
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0303 0.4084
Entamoeba histolytica hypothetical protein 0.0087 0.0311 0.1731
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0345 0.4648
Loa Loa (eye worm) ACC-1 protein 0.0059 0.0188 0.0963
Toxoplasma gondii histone deacetylase HDAC2 0.0417 0.1765 0.9188
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Mycobacterium ulcerans hypothetical protein 0.0042 0.0111 0.0983
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0059 0.0188 0.0963
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0114 0.0431 0.223
Brugia malayi nuclear hormone receptor family member odr-7 0.0089 0.0321 0.1653
Entamoeba histolytica hypothetical protein 0.0025 0.0037 0.0168
Trypanosoma cruzi glutaminyl cyclase, putative 0.0042 0.0111 0.0561
Schistosoma mansoni hypothetical protein 0.0162 0.0641 0.0638
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0215 0.023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0202 0.0198
Leishmania major glutaminyl cyclase, putative 0.0042 0.0111 0.0561
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0166 0.0658 0.0654
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Brugia malayi tailless protein 0.0089 0.0321 0.1653
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0059 0.0188 0.0963
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0303 0.4084
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Trypanosoma cruzi polo-like protein kinase, putative 0.0186 0.0747 0.3878
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Brugia malayi Steroid receptor seven-up type 2 0.0189 0.0761 0.3948
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0089 0.0321 0.0345
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0202 0.0216
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0059 0.0188 0.0201
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0189 0.0761 0.0757

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 0.01 uM Induction of p21 using Histone deacetylase inhibitors ChEMBL. 11831887
GI50 (functional) -9.674 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -9.304 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -9.291 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8.906 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8.866 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8.68 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8.267 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8.241 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.984 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 0.11 nM Inhibition of recombinant HDAC1 transfected in mouse NIH/3T3 assessed as [3H]acetic acid release by scintillation counting ChEMBL. 19362838
IC50 (functional) = 2 nM Inhibitory activity against HCT116 human colon cell growth ChEMBL. 14521422
IC50 (functional) = 4 nM Inhibitory activity against H1299 human lung carcinoma cell growth ChEMBL. 14521422
IC50 (binding) < 5 nM Inhibitory activity against histone deacetylase(HDAC) enzyme obtained from H1299 human lung carcinoma cell lysates ChEMBL. 14521422
IC50 (binding) = 100 nM Inhibitory concentration gainst Histone deacetylase 1 derived from NIH3T3 cells ChEMBL. 15163181
IC50 (functional) = 0.002 uM Concentration required to inhibit the HCT116 cell growth by 50%. ChEMBL. 11831887
IC50 (functional) = 0.004 uM Concentration required to inhibit the partially purified HDAC enzyme by 50% obtained from H1299 cell lysate ChEMBL. 11831887
IC50 (binding) < 0.005 uM Concentration required to inhibit human Histone deacetylase (HDAC) enzyme by 50% ChEMBL. 11831887
IC50 (binding) = 0.01 uM Inhibitory concentration against histone deacetylase activity ChEMBL. 11405644
IC50 (binding) = 0.01 uM Inhibitory concentration against maize histone deacetylase 2 ChEMBL. 15857140

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 11831887

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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