TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 399.511 | Formula: C23H21N5S
H donors: 1 H acceptors: 0 LogP: 5.85 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CN(c1ccc(cc1)/N=C/1\S/C(=N\c2ccccc2)/C(=N/c2ccccc2)/N1)C
InChi: 1S/C23H21N5S/c1-28(2)20-15-13-19(14-16-20)26-23-27-21(24-17-9-5-3-6-10-17)22(29-23)25-18-11-7-4-8-12-18/h3-16H,1-2H3,(H,24,26,27)/b25-22-
InChiKey: ZVDZXGJOEJSOLX-LVWGJNHUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	alpha tubulin	0.0213	0.0742	0.7814
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0412	0.0413
Trypanosoma brucei	alpha tubulin, putative	0.0084	0.0239	0.2096
Leishmania major	beta tubulin	0.0267	0.095	1
Trypanosoma cruzi	tubulin gamma chain	0.0149	0.0492	0.1516
Echinococcus granulosus	tubulin beta 4A class IVa	0.0267	0.095	0.0904
Trypanosoma cruzi	epsilon tubulin, putative	0.0149	0.0492	0.1516
Trypanosoma brucei	alpha tubulin	0.0213	0.0742	0.7691
Loa Loa (eye worm)	tubulin alpha chain	0.0213	0.0742	0.0743
Trypanosoma cruzi	tubulin delta chain	0.0065	0.0162	0.0384
Echinococcus multilocularis	tubulin alpha chain	0.0213	0.0742	0.0695
Schistosoma mansoni	tubulin subunit alpha	0.0213	0.0742	0.0695
Leishmania major	beta tubulin	0.0267	0.095	1
Leishmania major	epsilon tubulin, putative	0.0149	0.0492	0.5181
Echinococcus multilocularis	tubulin alpha chain	0.0213	0.0742	0.0695
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0213	0.0742	0.0695
Schistosoma mansoni	tubulin subunit alpha	0.0065	0.0162	0.0112
Echinococcus multilocularis	tubulin beta 1 chain	0.0267	0.095	0.0904
Plasmodium falciparum	alpha tubulin 2	0.0213	0.0742	0.7363
Onchocerca volvulus		0.0084	0.0239	1
Loa Loa (eye worm)	tubulin alpha 2	0.0149	0.0489	0.049
Leishmania major	alpha tubulin	0.0213	0.0742	0.7814
Echinococcus granulosus	tubulin alpha chain	0.0213	0.0742	0.0695
Echinococcus granulosus	Tubulin beta 2C chain	0.0267	0.095	0.0904
Trypanosoma cruzi	epsilon tubulin, putative	0.0149	0.0492	0.1516
Schistosoma mansoni	hypothetical protein	0.0166	0.0558	0.051
Schistosoma mansoni	tubulin subunit beta	0.0267	0.095	0.0904
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0213	0.0742	0.7691
Echinococcus granulosus	Tubulin beta 2C chain	0.0267	0.095	0.0904
Trypanosoma brucei	beta tubulin	0.0267	0.095	1
Loa Loa (eye worm)	tubulin alpha 2	0.0149	0.0489	0.049
Mycobacterium leprae	cell division protein FtsZ	0.0065	0.0162	1
Loa Loa (eye worm)	BEN-1 protein	0.0267	0.095	0.0951
Echinococcus multilocularis	tubulin epsilon chain	0.0149	0.0492	0.0444
Brugia malayi	Tubulin gamma chain	0.0149	0.0492	0.0492
Loa Loa (eye worm)	tubulin alpha 2	0.0064	0.0159	0.016
Echinococcus multilocularis	Tubulin beta 2C chain	0.0267	0.095	0.0904
Echinococcus granulosus	Tubulin beta 2C chain	0.0267	0.095	0.0904
Giardia lamblia	Alpha-tubulin	0.0213	0.0742	0.7363
Trypanosoma brucei	alpha tubulin	0.0213	0.0742	0.7691
Echinococcus granulosus	tubulin alpha chain	0.0213	0.0742	0.0695
Plasmodium vivax	tubulin beta chain, putative	0.0267	0.095	1
Toxoplasma gondii	beta-1 tubulin, putative	0.0267	0.095	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0065	0.0162	0.1243
Trichomonas vaginalis	tubulin beta chain, putative	0.0267	0.095	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0149	0.0492	0.491
Loa Loa (eye worm)	hypothetical protein	0.0149	0.0489	0.049
Echinococcus multilocularis	tubulin gamma 1 chain	0.0149	0.0492	0.0444
Leishmania major	gamma-tubulin	0.0149	0.0492	0.5181
Trichomonas vaginalis	tubulin beta chain, putative	0.0213	0.0742	0.7691
Echinococcus multilocularis	tubulin alpha chain	0.0213	0.0742	0.0695
Trichomonas vaginalis	tubulin alpha chain, putative	0.0267	0.095	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0213	0.0742	0.7691
Schistosoma mansoni	alpha tubulin	0.0213	0.0742	0.0695
Brugia malayi	tubulin alpha-2 chain	0.0213	0.0742	0.0742
Schistosoma mansoni	tubulin subunit gamma	0.0149	0.0492	0.0444
Giardia lamblia	Alpha-tubulin	0.0213	0.0742	0.7363
Treponema pallidum	cell division protein FtsZ	0.0065	0.0162	0.5
Echinococcus multilocularis	tubulin alpha 3 chain	0.0213	0.0742	0.0695
Loa Loa (eye worm)	beta-tubulin	0.0267	0.095	0.0951
Leishmania major	alpha tubulin	0.0213	0.0742	0.7814
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0051	0.0533
Brugia malayi	Tubulin alpha chain	0.0213	0.0742	0.0742
Schistosoma mansoni	tubulin subunit beta	0.0267	0.095	0.0904
Trichomonas vaginalis	tubulin gamma chain, putative	0.0149	0.0492	0.491
Entamoeba histolytica	tubulin gamma chain	0.0149	0.0492	0.5181
Trichomonas vaginalis	tubulin, putative	0.0267	0.095	1
Leishmania major	alpha tubulin	0.0213	0.0742	0.7814
Echinococcus multilocularis	tubulin alpha chain	0.0213	0.0742	0.0695
Trypanosoma brucei	tubulin gamma chain	0.0149	0.0492	0.491
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0477	0.0478
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0149	0.0489	0.049
Echinococcus granulosus	tubulin gamma 1 chain	0.0149	0.0492	0.0444
Brugia malayi	beta-tubulin, identical	0.0267	0.095	0.095
Echinococcus granulosus	Tubulin beta 2C chain	0.0267	0.095	0.0904
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0129	0.0412	0.0413
Schistosoma mansoni	tubulin subunit alpha	0.0213	0.0742	0.0695
Schistosoma mansoni	alpha tubulin	0.0213	0.0742	0.0695
Echinococcus granulosus	tubulin alpha 3 chain	0.0213	0.0742	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0778	0.2948	0.2952
Trypanosoma cruzi	tubulin delta chain	0.0065	0.0162	0.0384
Leishmania major	alpha tubulin	0.0213	0.0742	0.7814
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0149	0.0492	0.491
Toxoplasma gondii	beta-tubulin, putative	0.0267	0.095	1
Trypanosoma cruzi	beta tubulin, putative	0.0267	0.095	0.3088
Echinococcus granulosus	tubulin subunit beta	0.0267	0.095	0.0904
Toxoplasma gondii	alpha-tubulin I, putative	0.0213	0.0742	0.7691
Echinococcus multilocularis	geminin	0.0166	0.0558	0.051
Echinococcus granulosus	tubulin alpha chain	0.0213	0.0742	0.0695
Leishmania major	beta tubulin	0.0267	0.095	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0065	0.0162	0.1243
Loa Loa (eye worm)	alpha-tubulin	0.0213	0.0742	0.0743
Plasmodium falciparum	alpha tubulin 1	0.0213	0.0742	0.7363
Leishmania major	beta tubulin	0.0267	0.095	1
Schistosoma mansoni	tubulin subunit epsilon	0.0149	0.0492	0.0444
Echinococcus multilocularis	tubulin alpha 1C chain	0.0213	0.0742	0.0695
Trichomonas vaginalis	tubulin alpha chain, putative	0.0084	0.0239	0.2096
Echinococcus multilocularis	muscleblind protein 1	0.0145	0.0477	0.0428
Leishmania major	alpha tubulin	0.0213	0.0742	0.7814
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0213	0.0742	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0742	0.0743
Loa Loa (eye worm)	alpha-tubulin	0.0213	0.0742	0.0743
Plasmodium vivax	tubulin alpha chain, putative	0.0213	0.0742	0.7363
Echinococcus granulosus	tubulin alpha chain	0.0213	0.0742	0.0695
Trypanosoma brucei	tubulin delta chain	0.0065	0.0162	0.1243
Leishmania major	beta tubulin	0.0267	0.095	1
Trypanosoma brucei	beta tubulin	0.0267	0.095	1
Echinococcus multilocularis	tubulin delta chain	0.0065	0.0162	0.0112
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0065	0.0162	1
Trypanosoma brucei	epsilon tubulin	0.0149	0.0492	0.491
Echinococcus multilocularis	tubulin alpha 1C chain	0.0213	0.0742	0.0695
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0267	0.095	1
Plasmodium falciparum	tubulin beta chain	0.0267	0.095	1
Plasmodium falciparum	tubulin gamma chain	0.0149	0.0492	0.4188
Trypanosoma cruzi	zeta tubulin, putative	0.0065	0.0162	0.0384
Trypanosoma brucei	alpha tubulin	0.0213	0.0742	0.7691
Leishmania major	beta tubulin	0.0267	0.095	1
Entamoeba histolytica	tubulin alpha-1 chain	0.0213	0.0742	0.7814
Schistosoma mansoni	alpha tubulin	0.0213	0.0742	0.0695
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.2584	1	1
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0065	0.0162	0.1243
Echinococcus multilocularis	Tubulin beta 2C chain	0.0267	0.095	0.0904
Trichomonas vaginalis	tubulin, putative	0.0084	0.0239	0.2096
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0065	0.0162	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0267	0.095	0.0904
Echinococcus granulosus	beta tubulin	0.0267	0.095	0.0904
Echinococcus granulosus	tubulin beta 1 chain	0.0267	0.095	0.0904
Leishmania major	beta tubulin	0.0267	0.095	1
Echinococcus granulosus	muscleblind protein	0.0145	0.0477	0.0428
Echinococcus multilocularis	tubulin alpha chain	0.0213	0.0742	0.0695
Echinococcus multilocularis	tubulin subunit TubB	0.0213	0.0742	0.0695
Trypanosoma brucei	beta tubulin	0.0149	0.0492	0.491
Schistosoma mansoni	tubulin subunit alpha	0.0213	0.0742	0.0695
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.0036	0.2204
Leishmania major	alpha tubulin	0.0213	0.0742	0.7814
Trichomonas vaginalis	tubulin beta chain, putative	0.0213	0.0742	0.7691
Entamoeba histolytica	tubulin family protein	0.0267	0.095	1
Trichomonas vaginalis	tubulin, putative	0.0065	0.0162	0.1243
Brugia malayi	Tubulin alpha chain	0.0065	0.0162	0.0162
Loa Loa (eye worm)	BEN-1 protein	0.0267	0.095	0.0951
Trypanosoma brucei	beta tubulin	0.0267	0.095	1
Echinococcus multilocularis	muscleblind protein	0.0145	0.0477	0.0428
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0782	0.2963	1
Schistosoma mansoni	tubulin subunit beta	0.0267	0.095	0.0904
Plasmodium falciparum	tubulin epsilon chain, putative	0.0149	0.0492	0.4188
Echinococcus multilocularis	tubulin alpha	0.0149	0.0492	0.0444
Echinococcus granulosus	Tubulin beta 2C chain	0.0267	0.095	0.0904
Trichomonas vaginalis	tubulin alpha chain, putative	0.0084	0.0239	0.2096
Trichomonas vaginalis	tubulin beta chain, putative	0.0084	0.0239	0.2096
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0213	0.0742	0.0695
Leishmania major	alpha tubulin	0.0213	0.0742	0.7814
Leishmania major	beta tubulin	0.0267	0.095	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0213	0.0742	0.7691
Echinococcus multilocularis	beta tubulin	0.0267	0.095	0.0904
Loa Loa (eye worm)	inositol-1	0.0036	0.0051	0.0051
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0213	0.0742	0.0695
Leishmania major	beta tubulin	0.0267	0.095	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.0213	0.0742	0.0695
Plasmodium vivax	tubulin epsilon chain, putative	0.0149	0.0492	0.4188
Brugia malayi	Cell division protein ftsZ	0.0065	0.0162	0.0162
Echinococcus granulosus	tubulin alpha 3 chain	0.0213	0.0742	0.0695
Giardia lamblia	Beta tubulin	0.0267	0.095	1
Toxoplasma gondii	alpha tubulin TUBA1	0.0213	0.0742	0.7691
Giardia lamblia	Beta tubulin	0.0267	0.095	1
Echinococcus granulosus	tubulin epsilon chain	0.0149	0.0492	0.0444
Leishmania major	alpha tubulin	0.0213	0.0742	0.7814
Trichomonas vaginalis	tubulin gamma chain, putative	0.0065	0.0162	0.1243
Echinococcus granulosus	tubulin alpha 1C chain	0.0213	0.0742	0.0695
Echinococcus granulosus	tubulin alpha 1C chain	0.0213	0.0742	0.0695
Leishmania major	beta tubulin	0.0267	0.095	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0477	0.0478
Brugia malayi	Tubulin alpha-2 chain	0.0213	0.0742	0.0742
Leishmania major	beta tubulin	0.0267	0.095	1
Brugia malayi	tubulin alpha chain - mouse	0.0213	0.0742	0.0742
Trypanosoma brucei	epsilon tubulin	0.0149	0.0492	0.491
Echinococcus multilocularis	hypothetical protein	0.0213	0.0742	0.0695
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0051	0.3116
Brugia malayi	Tubulin beta chain	0.0065	0.0162	0.0162
Loa Loa (eye worm)	tubulin gamma chain	0.0149	0.0492	0.0493
Trypanosoma cruzi	alpha tubulin, putative	0.0213	0.0742	0.2375
Echinococcus granulosus	tubulin alpha chain	0.0213	0.0742	0.0695
Leishmania major	beta tubulin	0.0267	0.095	1
Toxoplasma gondii	beta tubulin	0.0267	0.095	1
Brugia malayi	Muscleblind-like protein	0.0145	0.0477	0.0477
Echinococcus granulosus	Tubulin alpha 1 chain	0.0213	0.0742	0.0695
Echinococcus granulosus	beta tubulin	0.0267	0.095	0.0904
Trypanosoma brucei	epsilon tubulin	0.0149	0.0492	0.491
Trypanosoma brucei	alpha tubulin	0.0213	0.0742	0.7691
Trichomonas vaginalis	tubulin beta chain, putative	0.0213	0.0742	0.7691
Trypanosoma cruzi	zeta tubulin, putative	0.0065	0.0162	0.0384
Echinococcus granulosus	Tubulin alpha 1 chain	0.0213	0.0742	0.0695
Leishmania major	beta tubulin	0.0267	0.095	1
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0036	0.2204
Brugia malayi	Tubulin beta chain	0.0084	0.0239	0.0239
Echinococcus granulosus	geminin	0.0166	0.0558	0.051
Entamoeba histolytica	tubulin alpha chain, putative	0.0213	0.0742	0.7814
Brugia malayi	alpha-tubulin	0.0213	0.0742	0.0742
Schistosoma mansoni	tubulin subunit delta	0.0065	0.0162	0.0112
Plasmodium vivax	tubulin gamma chain, putative	0.0149	0.0492	0.4188
Echinococcus granulosus	tubulin alpha	0.0149	0.0492	0.0444
Trypanosoma brucei	zeta tubulin	0.0065	0.0162	0.1243
Trypanosoma brucei	zeta tubulin, putative	0.0065	0.0162	0.1243
Echinococcus multilocularis	tubulin subunit beta	0.0267	0.095	0.0904
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0051	0.0533
Echinococcus granulosus	tubulin delta chain	0.0065	0.0162	0.0112
Plasmodium vivax	tubulin alpha chain, putative	0.0213	0.0742	0.7363
Echinococcus granulosus	Tubulin alpha 1 chain	0.0213	0.0742	0.0695
Echinococcus granulosus	tubulin subunit TubB	0.0213	0.0742	0.0695
Leishmania major	beta tubulin	0.0267	0.095	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0065	0.0162	0.1243
Schistosoma mansoni	tubulin subunit beta	0.0267	0.095	0.0904
Leishmania major	alpha tubulin	0.0213	0.0742	0.7814
Loa Loa (eye worm)	tubulin beta chain	0.0267	0.095	0.0951
Schistosoma mansoni	protein kinase	0.2584	1	1
Brugia malayi	Tubulin beta-1 chain	0.0267	0.095	0.095
Loa Loa (eye worm)	tubulin beta-2A chain	0.0267	0.095	0.0951
Echinococcus granulosus	alpha tubulin	0.0213	0.0742	0.0695
Loa Loa (eye worm)	hypothetical protein	0.2581	0.9985	1
Giardia lamblia	Beta tubulin	0.0267	0.095	1
Schistosoma mansoni	tubulin subunit beta	0.0267	0.095	0.0904
Leishmania major	zeta tubulin, putative	0.0065	0.0162	0.1709
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0162	0.1243
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0162	0.1243
Loa Loa (eye worm)	STE/STE11/ASK protein kinase	0.0782	0.2963	0.2967
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0213	0.0742	0.7691
Brugia malayi	Tubulin alpha-2 chain	0.0213	0.0742	0.0742
Leishmania major	alpha tubulin	0.0213	0.0742	0.7814
Schistosoma mansoni	tubulin subunit beta	0.0267	0.095	0.0904
Trypanosoma brucei	beta tubulin	0.0267	0.095	1
Schistosoma mansoni	protein kinase	0.2584	1	1
Mycobacterium ulcerans	cell division protein FtsZ	0.0065	0.0162	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0782	0.2963	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.2584	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0149	0.0492	0.491
Trichomonas vaginalis	tubulin beta chain, putative	0.0213	0.0742	0.7691
Brugia malayi	Inositol-1	0.0036	0.0051	0.0051
Entamoeba histolytica	tubulin family protein	0.0267	0.095	1
Trichomonas vaginalis	tubulin, putative	0.0084	0.0239	0.2096
Schistosoma mansoni	tubulin subunit beta	0.0065	0.0162	0.0112
Giardia lamblia	Gamma tubulin	0.0149	0.0492	0.4188
Echinococcus granulosus	peroxisome assembly protein 26	0.0213	0.0742	0.0695
Trichomonas vaginalis	tubulin alpha chain, putative	0.0084	0.0239	0.2096
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0149	0.0489	0.4876
Loa Loa (eye worm)	tubulin beta-1 chain	0.0267	0.095	0.0951
Leishmania major	beta tubulin	0.0267	0.095	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0267	0.095	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0213	0.0742	0.0695
Echinococcus multilocularis	Tubulin beta 2C chain	0.0267	0.095	0.0904
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0129	0.0412	0.4023
Trichomonas vaginalis	tubulin gamma chain, putative	0.0267	0.095	1
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0267	0.095	0.0904
Leishmania major	beta tubulin	0.0267	0.095	1
Schistosoma mansoni	hypothetical protein	0.0166	0.0558	0.051
Loa Loa (eye worm)	tubulin beta-4 chain	0.0267	0.095	0.0951
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0084	0.0239	0.2096
Echinococcus multilocularis	beta tubulin	0.0267	0.095	0.0904
Loa Loa (eye worm)	tubulin alpha chain	0.0213	0.0742	0.0743
Trichomonas vaginalis	tubulin beta chain, putative	0.0213	0.0742	0.7691
Leishmania major	beta tubulin	0.0267	0.095	1
Leishmania major	beta tubulin	0.0267	0.095	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0267	0.095	0.0904
Leishmania major	delta tubulin, putative	0.0065	0.0162	0.1709
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0789	0.299	0.2955
Leishmania major	alpha tubulin	0.0213	0.0742	0.7814
Loa Loa (eye worm)	tubulin beta chain	0.0065	0.0162	0.0163

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4.309	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2000382

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1650261