Detailed information for compound 1656942

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 365.49 | Formula: C16H15NO3S3
  • H donors: 2 H acceptors: 3 LogP: 4.23 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSc1cc(NS(=O)(=O)c2cccs2)c2c(c1O)cccc2
  • InChi: 1S/C16H15NO3S3/c1-2-21-14-10-13(11-6-3-4-7-12(11)16(14)18)17-23(19,20)15-8-5-9-22-15/h3-10,17-18H,2H2,1H3
  • InChiKey: FBDCTYOJYCGNDI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0011 0.0091
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.075 0.6067
Schistosoma mansoni importin beta-1 0.0029 0.004 0.0266
Toxoplasma gondii alpha tubulin TUBA1 0.026 0.1237 0.4665
Loa Loa (eye worm) tubulin beta-1 chain 0.014 0.0615 0.4126
Echinococcus granulosus Tubulin beta 2C chain 0.014 0.0615 0.4126
Schistosoma mansoni tubulin subunit beta 0.014 0.0615 0.4126
Schistosoma mansoni tubulin subunit epsilon 0.014 0.0615 0.4126
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0119 0.0963
Trichomonas vaginalis tubulin beta chain, putative 0.026 0.1237 1
Giardia lamblia PHD finger protein 15 0.0028 0.0037 0.0138
Leishmania major alpha tubulin 0.026 0.1237 0.4665
Trypanosoma brucei tubulin delta chain 0.0061 0.0204 0.0771
Trypanosoma cruzi beta tubulin, putative 0.014 0.0615 0.2319
Echinococcus multilocularis tubulin alpha chain 0.026 0.1237 0.1454
Loa Loa (eye worm) RNA binding protein 0.0067 0.0236 0.1582
Echinococcus granulosus Tubulin beta 2C chain 0.014 0.0615 0.4126
Onchocerca volvulus Alhambra homolog 0.0028 0.0037 0.0018
Entamoeba histolytica hypothetical protein 0.0023 0.0011 0.0091
Plasmodium falciparum tubulin epsilon chain, putative 0.014 0.0615 0.2319
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0608 0.0715
Trypanosoma brucei alpha tubulin, putative 0.0079 0.03 0.1131
Schistosoma mansoni hypothetical protein 0.0043 0.0111 0.0744
Brugia malayi Telomerase reverse transcriptase 0.1417 0.7238 1
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0204 0.1653
Echinococcus granulosus Tubulin alpha 1 chain 0.026 0.1237 0.8301
Leishmania major alpha tubulin 0.026 0.1237 0.4665
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1662 0.8507 1
Brugia malayi Tubulin gamma chain 0.014 0.0615 0.0849
Schistosoma mansoni transient receptor potential channel 0.0097 0.0394 0.2646
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0021 0.0078
Echinococcus granulosus beta tubulin 0.014 0.0615 0.4126
Leishmania major delta tubulin, putative 0.0061 0.0204 0.0771
Trichomonas vaginalis tubulin alpha chain, putative 0.014 0.0615 0.497
Plasmodium falciparum tubulin beta chain 0.014 0.0615 0.2319
Schistosoma mansoni patched 1 0.0044 0.0119 0.0799
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.0608 0.4081
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0365 0.2955
Brugia malayi Importin beta-1 subunit 0.0029 0.004 0.0055
Entamoeba histolytica hypothetical protein 0.0038 0.0085 0.0687
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0365 0.2453
Trichomonas vaginalis tubulin gamma chain, putative 0.014 0.0615 0.497
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0656 0.0906
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0371 0.0436
Loa Loa (eye worm) hypothetical protein 0.0025 0.0021 0.0139
Leishmania major beta tubulin 0.014 0.0615 0.2319
Plasmodium vivax tubulin epsilon chain, putative 0.014 0.0615 0.2319
Echinococcus granulosus tubulin alpha 0.014 0.0615 0.4126
Trypanosoma brucei epsilon tubulin 0.014 0.0615 0.2319
Leishmania major alpha tubulin 0.026 0.1237 0.4665
Loa Loa (eye worm) tubulin beta chain 0.0061 0.0204 0.1372
Loa Loa (eye worm) hypothetical protein 0.0054 0.0171 0.1145
Loa Loa (eye worm) tubulin alpha chain 0.026 0.1237 0.8301
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.0025 0.0018 0.0123
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.1202 0.166
Brugia malayi Tubulin alpha-2 chain 0.026 0.1237 0.1709
Echinococcus granulosus snurportin 1 0.0309 0.149 1
Entamoeba histolytica tubulin alpha chain, putative 0.026 0.1237 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0365 0.2955
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.0654 0.4386
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.075 0.6067
Plasmodium vivax importin-beta 2, putative 0.0029 0.004 0.0149
Echinococcus multilocularis Tubulin beta 2C chain 0.014 0.0615 0.0723
Echinococcus granulosus tubulin beta 1 chain 0.014 0.0615 0.4126
Loa Loa (eye worm) tubulin alpha 2 0.0199 0.0922 0.6188
Schistosoma mansoni alpha tubulin 0.026 0.1237 0.8301
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0132 0.0182
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0085 0.057
Echinococcus multilocularis expressed conserved protein 0.0097 0.0392 0.046
Plasmodium vivax tubulin beta chain, putative 0.014 0.0615 0.2319
Loa Loa (eye worm) tubulin alpha 2 0.012 0.0512 0.3435
Trichomonas vaginalis tubulin beta chain, putative 0.026 0.1237 1
Onchocerca volvulus 0.0079 0.03 0.0282
Echinococcus granulosus tubulin delta chain 0.0061 0.0204 0.1372
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0236 0.0326
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0365 0.1378
Echinococcus multilocularis peroxisome assembly protein 26 0.026 0.1237 0.1454
Giardia lamblia Beta tubulin 0.014 0.0615 0.2319
Echinococcus multilocularis Tubulin beta 2C chain 0.014 0.0615 0.0723
Brugia malayi jmjC domain containing protein 0.0093 0.0371 0.0512
Trypanosoma brucei zeta tubulin 0.0061 0.0204 0.0771
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0018 0.0025
Brugia malayi beta-tubulin, identical 0.014 0.0615 0.0849
Schistosoma mansoni hypothetical protein 0.0047 0.0132 0.0886
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0085 0.057
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.075 0.0733
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.075 0.6067
Trichomonas vaginalis tubulin alpha chain, putative 0.0079 0.03 0.2425
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.004 0.0149
Schistosoma mansoni tubulin subunit beta 0.014 0.0615 0.4126
Leishmania major alpha tubulin 0.026 0.1237 0.4665
Trichomonas vaginalis tubulin epsilon chain, putative 0.0061 0.0204 0.1653
Leishmania major alpha tubulin 0.026 0.1237 0.4665
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0608 0.4081
Echinococcus multilocularis tubulin alpha 1C chain 0.026 0.1237 0.1454
Trichomonas vaginalis tubulin epsilon chain, putative 0.026 0.1237 1
Echinococcus granulosus tubulin alpha chain 0.026 0.1237 0.8301
Echinococcus granulosus alpha tubulin 0.026 0.1237 0.8301
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1202 0.9715
Loa Loa (eye worm) tubulin alpha-2 chain 0.026 0.1237 0.8301
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0365 0.2453
Echinococcus multilocularis Tubulin beta 2C chain 0.014 0.0615 0.0723
Leishmania major alpha tubulin 0.026 0.1237 0.4665
Loa Loa (eye worm) tubulin beta-4 chain 0.014 0.0615 0.4126
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.026 0.1237 1
Loa Loa (eye worm) beta-tubulin 0.014 0.0615 0.4126
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.0394 0.2646
Brugia malayi alpha-tubulin 0.026 0.1237 0.1709
Echinococcus multilocularis tubulin alpha chain 0.026 0.1237 0.1454
Echinococcus multilocularis tubulin subunit beta 0.014 0.0615 0.0723
Plasmodium falciparum importin beta, putative 0.0029 0.004 0.0149
Leishmania major beta tubulin 0.014 0.0615 0.2319
Trypanosoma cruzi epsilon tubulin, putative 0.014 0.0615 0.2319
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0267 0.1272 1
Echinococcus granulosus Tubulin alpha 1 chain 0.026 0.1237 0.8301
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0236 0.0277
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0413 0.0571
Schistosoma mansoni kinase 0.0047 0.0131 0.0882
Leishmania major beta tubulin 0.014 0.0615 0.2319
Schistosoma mansoni tubulin subunit beta 0.014 0.0615 0.4126
Echinococcus granulosus tubulin alpha chain 0.026 0.1237 0.8301
Brugia malayi hypothetical protein 0.0025 0.0021 0.0029
Schistosoma mansoni hypothetical protein 0.0047 0.0132 0.0886
Entamoeba histolytica tubulin family protein 0.014 0.0615 0.497
Trichomonas vaginalis tubulin beta chain, putative 0.026 0.1237 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0608 0.4081
Entamoeba histolytica hypothetical protein 0.0038 0.0085 0.0687
Echinococcus multilocularis tubulin alpha chain 0.026 0.1237 0.1454
Trypanosoma cruzi tubulin delta chain 0.0061 0.0204 0.0771
Brugia malayi Bromodomain containing protein 0.0028 0.0037 0.005
Echinococcus multilocularis Tubulin alpha 1 chain 0.026 0.1237 0.1454
Echinococcus multilocularis tubulin delta chain 0.0061 0.0204 0.024
Brugia malayi Tubulin beta-1 chain 0.014 0.0615 0.0849
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0067 0.0452
Trypanosoma cruzi alpha tubulin, putative 0.026 0.1237 0.4665
Trichomonas vaginalis tubulin gamma chain, putative 0.014 0.0615 0.497
Loa Loa (eye worm) hypothetical protein 0.0061 0.0207 0.1387
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0021 0.0078
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0018 0.0069
Schistosoma mansoni hypothetical protein 0.0043 0.0111 0.0744
Trichomonas vaginalis tubulin beta chain, putative 0.026 0.1237 1
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1202 0.9715
Leishmania major importin beta-1 subunit, putative 0.0023 0.0011 0.0042
Brugia malayi RNA, U transporter 1 0.0082 0.0316 0.0436
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0193 0.1295
Toxoplasma gondii RNA-directed DNA polymerase 0.0533 0.2651 1
Giardia lamblia Alpha-tubulin 0.026 0.1237 0.4665
Trypanosoma brucei zeta tubulin, putative 0.0061 0.0204 0.0771
Loa Loa (eye worm) hypothetical protein 0.026 0.1237 0.8301
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0119 0.0799
Schistosoma mansoni tubulin subunit alpha 0.026 0.1237 0.8301
Echinococcus granulosus tubulin beta 4A class IVa 0.014 0.0615 0.4126
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0608 0.4081
Brugia malayi Tubulin beta chain 0.0061 0.0204 0.0282
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0181 0.0827 0.6683
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0079 0.03 0.2425
Loa Loa (eye worm) tubulin gamma chain 0.014 0.0615 0.4126
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0533 0.2651 1
Trypanosoma brucei beta tubulin 0.014 0.0615 0.2319
Loa Loa (eye worm) tubulin beta chain 0.014 0.0615 0.4126
Schistosoma mansoni tubulin subunit gamma 0.014 0.0615 0.4126
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.0654 0.0768
Echinococcus granulosus tubulin alpha 1C chain 0.026 0.1237 0.8301
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0236 0.1582
Brugia malayi Cell division protein ftsZ 0.0061 0.0204 0.0282
Trichomonas vaginalis tubulin epsilon chain, putative 0.014 0.0615 0.497
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0365 0.1378
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0519
Brugia malayi Tubulin alpha chain 0.026 0.1237 0.1709
Trypanosoma brucei epsilon tubulin 0.014 0.0615 0.2319
Plasmodium falciparum telomerase reverse transcriptase 0.0533 0.2651 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0236 0.1582
Giardia lamblia Beta tubulin 0.014 0.0615 0.2319
Plasmodium vivax delta tubulin, putative 0.0061 0.0204 0.0771
Toxoplasma gondii beta-1 tubulin, putative 0.014 0.0615 0.2319
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.0608 0.084
Echinococcus multilocularis GPCR, family 2 0.0047 0.0132 0.0155
Leishmania major gamma-tubulin 0.014 0.0615 0.2319
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0533 0.2651 1
Trypanosoma brucei epsilon tubulin 0.014 0.0615 0.2319
Trichomonas vaginalis tubulin beta chain, putative 0.026 0.1237 1
Leishmania major beta tubulin 0.014 0.0615 0.2319
Treponema pallidum cell division protein FtsZ 0.0061 0.0204 0.5
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.0424 0.343
Echinococcus granulosus tubulin epsilon chain 0.014 0.0615 0.4126
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0365 0.2955
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0199 0.0922 0.6188
Echinococcus multilocularis Tubulin beta 2C chain 0.014 0.0615 0.0723
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.0656 0.0906
Schistosoma mansoni alpha tubulin 0.026 0.1237 0.8301
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0119 0.014
Trypanosoma brucei tubulin gamma chain 0.014 0.0615 0.2319
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0287 0.1377 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0365 0.2955
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0067 0.0079
Trypanosoma brucei telomerase reverse transcriptase 0.0533 0.2651 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0037 0.0245
Brugia malayi tubulin alpha chain - mouse 0.026 0.1237 0.1709
Giardia lamblia Kinase, PLK 0.0092 0.0365 0.1378
Echinococcus multilocularis hypothetical protein 0.026 0.1237 0.1454
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.1202 0.8065
Echinococcus multilocularis beta tubulin 0.014 0.0615 0.0723
Echinococcus granulosus tubulin alpha chain 0.026 0.1237 0.8301
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.0245
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.0394 0.2646
Trypanosoma brucei alpha tubulin 0.026 0.1237 0.4665
Leishmania major beta tubulin 0.014 0.0615 0.2319
Giardia lamblia Epsilon tubulin 0.0061 0.0204 0.0771
Trypanosoma brucei beta tubulin 0.014 0.0615 0.2319
Echinococcus granulosus tubulin alpha 3 chain 0.026 0.1237 0.8301
Echinococcus multilocularis Tubulin alpha 1 chain 0.026 0.1237 0.1454
Echinococcus granulosus peroxisome assembly protein 26 0.026 0.1237 0.8301
Loa Loa (eye worm) hypothetical protein 0.0101 0.0413 0.2774
Trypanosoma brucei beta tubulin 0.014 0.0615 0.2319
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0365 0.2955
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0018 0.0149
Leishmania major beta tubulin 0.014 0.0615 0.2319
Leishmania major alpha tubulin 0.026 0.1237 0.4665
Toxoplasma gondii alpha-tubulin I, putative 0.026 0.1237 0.4665
Echinococcus multilocularis snurportin 1 0.0309 0.149 0.1751
Leishmania major alpha tubulin 0.026 0.1237 0.4665
Echinococcus granulosus tubulin gamma 1 chain 0.014 0.0615 0.4126
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0608 0.4081
Trichomonas vaginalis tubulin, putative 0.0079 0.03 0.2425
Loa Loa (eye worm) hypothetical protein 0.0047 0.0132 0.0886
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1202 0.9715
Schistosoma mansoni tubulin subunit delta 0.0061 0.0204 0.1372
Echinococcus multilocularis tubulin beta 1 chain 0.014 0.0615 0.0723
Loa Loa (eye worm) BEN-1 protein 0.014 0.0615 0.4126
Schistosoma mansoni tubulin subunit alpha 0.026 0.1237 0.8301
Echinococcus multilocularis tubulin epsilon chain 0.014 0.0615 0.0723
Trichomonas vaginalis tubulin alpha chain, putative 0.0079 0.03 0.2425
Schistosoma mansoni hypothetical protein 0.0028 0.0037 0.0245
Leishmania major beta tubulin 0.014 0.0615 0.2319
Echinococcus granulosus tubulin alpha chain 0.026 0.1237 0.8301
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0132 0.0155
Trypanosoma brucei polo-like protein kinase 0.0092 0.0365 0.1378
Echinococcus granulosus tubulin subunit beta 0.014 0.0615 0.4126
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0094 0.0631
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1202 0.9715
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0018 0.0069
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0018 0.0025
Echinococcus multilocularis beta tubulin 0.014 0.0615 0.0723
Echinococcus granulosus tubulin alpha 3 chain 0.026 0.1237 0.8301
Trypanosoma cruzi tubulin gamma chain 0.014 0.0615 0.2319
Echinococcus granulosus tubulin alpha chain 0.026 0.1237 0.8301
Brugia malayi Tubulin alpha chain 0.0061 0.0204 0.0282
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0365 0.0505
Trypanosoma brucei alpha tubulin 0.026 0.1237 0.4665
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0236 0.1582
Schistosoma mansoni transient receptor potential channel 0.0064 0.0223 0.15
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.075 0.6067
Echinococcus multilocularis tubulin, beta 4A class IVa 0.014 0.0615 0.0723
Leishmania major alpha tubulin 0.026 0.1237 0.4665
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.0424 0.0586
Trypanosoma brucei alpha tubulin 0.026 0.1237 0.4665
Loa Loa (eye worm) hypothetical protein 0.0025 0.0018 0.0123
Trichomonas vaginalis tubulin alpha chain, putative 0.0079 0.03 0.2425
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0037 0.0138
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0199 0.0922 0.7455
Entamoeba histolytica tubulin family protein 0.014 0.0615 0.497
Echinococcus granulosus tar DNA binding protein 0.0067 0.0236 0.1582
Trypanosoma cruzi zeta tubulin, putative 0.0061 0.0204 0.0771
Echinococcus multilocularis tubulin alpha 3 chain 0.026 0.1237 0.1454
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0371 0.2488
Echinococcus granulosus Tubulin beta 2C chain 0.014 0.0615 0.4126
Brugia malayi PHD-finger family protein 0.0028 0.0037 0.005
Trichomonas vaginalis tubulin, putative 0.014 0.0615 0.497
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0018 0.0149
Toxoplasma gondii beta tubulin 0.014 0.0615 0.2319
Mycobacterium tuberculosis Cell division protein FtsZ 0.0061 0.0204 0.1484
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.075 0.6067
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0287 0.1377 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0021 0.0078
Trypanosoma cruzi epsilon tubulin, putative 0.014 0.0615 0.2319
Loa Loa (eye worm) alpha-tubulin 0.026 0.1237 0.8301
Trypanosoma brucei beta tubulin 0.014 0.0615 0.2319
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0365 0.2453
Leishmania major beta tubulin 0.014 0.0615 0.2319
Loa Loa (eye worm) tubulin beta-2A chain 0.014 0.0615 0.4126
Giardia lamblia Telomerase catalytic subunit 0.0533 0.2651 1
Schistosoma mansoni transient receptor potential channel 0.0064 0.0223 0.15
Echinococcus multilocularis importin subunit beta 1 0.0029 0.004 0.0047
Leishmania major beta tubulin 0.014 0.0615 0.2319
Leishmania major telomerase reverse transcriptase, putative 0.0533 0.2651 1
Schistosoma mansoni hypothetical protein 0.0101 0.0413 0.2774
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0266
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0037 0.0138
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0021 0.0078
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0223 0.15
Plasmodium vivax tubulin alpha chain, putative 0.026 0.1237 0.4665
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1202 0.9715
Schistosoma mansoni hypothetical protein 0.0043 0.0111 0.0744
Loa Loa (eye worm) hypothetical protein 0.0181 0.0827 0.5548
Leishmania major beta tubulin 0.014 0.0615 0.2319
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0272 0.1824
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0365 0.0348
Echinococcus multilocularis Tubulin alpha 1 chain 0.026 0.1237 0.1454
Trichomonas vaginalis tubulin epsilon chain, putative 0.026 0.1237 1
Echinococcus granulosus tubulin alpha 1C chain 0.026 0.1237 0.8301
Echinococcus multilocularis tubulin subunit TubB 0.026 0.1237 0.1454
Trichomonas vaginalis tubulin beta chain, putative 0.026 0.1237 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.014 0.0615 0.2319
Loa Loa (eye worm) tubulin alpha chain 0.026 0.1237 0.8301
Leishmania major epsilon tubulin, putative 0.014 0.0615 0.2319
Brugia malayi RNA binding protein 0.0067 0.0236 0.0326
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0797 0.6442
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0018 0.0149
Toxoplasma gondii beta-tubulin, putative 0.014 0.0615 0.2319
Leishmania major beta tubulin 0.014 0.0615 0.2319
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0132 0.0886
Trichomonas vaginalis tubulin beta chain, putative 0.014 0.0615 0.497
Leishmania major zeta tubulin, putative 0.0061 0.0204 0.0771
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0125 0.1012
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0105 0.0432 0.2902
Schistosoma mansoni alpha tubulin 0.026 0.1237 0.8301
Echinococcus multilocularis tubulin alpha chain 0.026 0.1237 0.1454
Leishmania major alpha tubulin 0.026 0.1237 0.4665
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0037 0.0138
Loa Loa (eye worm) hypothetical protein 0.0097 0.0394 0.2646
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0061 0.0204 0.0771
Trypanosoma cruzi zeta tubulin, putative 0.0061 0.0204 0.0771
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0077 0.0519
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0021 0.0078
Giardia lamblia Alpha-tubulin 0.026 0.1237 0.4665
Schistosoma mansoni tubulin subunit beta 0.014 0.0615 0.4126
Echinococcus granulosus Tubulin beta 2C chain 0.014 0.0615 0.4126
Trichomonas vaginalis tubulin beta chain, putative 0.0079 0.03 0.2425
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.075 0.6067
Brugia malayi Tubulin alpha-2 chain 0.026 0.1237 0.1709
Leishmania major beta tubulin 0.014 0.0615 0.2319
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0236 0.1582
Schistosoma mansoni hypothetical protein 0.0047 0.0132 0.0886
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0011 0.0091
Leishmania major beta tubulin 0.014 0.0615 0.2319
Brugia malayi hypothetical protein 0.0038 0.0085 0.0117
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0365 0.1378
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0077 0.0091
Trichomonas vaginalis tubulin, putative 0.0061 0.0204 0.1653
Schistosoma mansoni hypothetical protein 0.0043 0.0111 0.0744
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0608 0.4081
Echinococcus multilocularis tubulin alpha 3 chain 0.026 0.1237 0.1454
Schistosoma mansoni tubulin subunit alpha 0.0061 0.0204 0.1372
Leishmania major alpha tubulin 0.026 0.1237 0.4665
Echinococcus granulosus GPCR family 2 0.0047 0.0132 0.0886
Echinococcus granulosus Tubulin beta 2C chain 0.014 0.0615 0.4126
Loa Loa (eye worm) hypothetical protein 0.0148 0.0656 0.4401
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0021 0.0078
Leishmania major beta tubulin 0.014 0.0615 0.2319
Giardia lamblia Delta tubulin 0.0061 0.0204 0.0771
Schistosoma mansoni hypothetical protein 0.0038 0.0085 0.057
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0236 0.1582
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0018 0.0069
Plasmodium falciparum phd finger protein, putative 0.0028 0.0037 0.0138
Trichomonas vaginalis tubulin gamma chain, putative 0.014 0.0615 0.497
Schistosoma mansoni tubulin subunit alpha 0.026 0.1237 0.8301
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0061 0.0204 0.0771
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1202 0.9715
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0236 0.1582
Echinococcus multilocularis protein patched 0.0044 0.0119 0.014
Leishmania major beta tubulin 0.014 0.0615 0.2319
Loa Loa (eye worm) tubulin alpha 2 0.0199 0.0922 0.6188
Echinococcus granulosus tubulin subunit TubB 0.026 0.1237 0.8301
Echinococcus granulosus importin subunit beta 1 0.0029 0.004 0.0266
Loa Loa (eye worm) hypothetical protein 0.0033 0.0061 0.0406
Leishmania major beta tubulin 0.014 0.0615 0.2319
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0365 0.2955
Trichomonas vaginalis tubulin, putative 0.0079 0.03 0.2425
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0085 0.01
Echinococcus granulosus Tubulin alpha 1 chain 0.026 0.1237 0.8301
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0236 0.1582
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0365 0.2955
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.0424 0.0499
Brugia malayi TAR-binding protein 0.0067 0.0236 0.0326
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.0377 0.2533
Plasmodium vivax tubulin gamma chain, putative 0.014 0.0615 0.2319
Echinococcus granulosus expressed conserved protein 0.0097 0.0392 0.2629
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0132 0.0182
Loa Loa (eye worm) hypothetical protein 0.0103 0.0424 0.2847
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0018 0.0025
Leishmania major beta tubulin 0.014 0.0615 0.2319
Brugia malayi jmjC domain containing protein 0.0034 0.0067 0.0093
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0037 0.0043
Brugia malayi tubulin alpha-2 chain 0.026 0.1237 0.1709
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.0424 0.2847
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0223 0.0263
Loa Loa (eye worm) hypothetical protein 0.0044 0.0119 0.0799
Schistosoma mansoni tubulin subunit beta 0.0061 0.0204 0.1372
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.004 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0204 0.1653
Loa Loa (eye worm) hypothetical protein 0.0049 0.0141 0.0949
Plasmodium vivax telomerase reverse transcriptase, putative 0.0533 0.2651 1
Plasmodium falciparum alpha tubulin 1 0.026 0.1237 0.4665
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0061 0.0204 0.1653
Mycobacterium ulcerans cell division protein FtsZ 0.0061 0.0204 0.137
Giardia lamblia Gamma tubulin 0.014 0.0615 0.2319
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0037 0.0245
Entamoeba histolytica hypothetical protein 0.0038 0.0085 0.0687
Entamoeba histolytica tubulin alpha-1 chain 0.026 0.1237 1
Loa Loa (eye worm) hypothetical protein 0.0199 0.0922 0.6188
Echinococcus multilocularis tubulin alpha chain 0.026 0.1237 0.1454
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0365 0.043
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.075 0.6067
Echinococcus multilocularis tubulin alpha 1C chain 0.026 0.1237 0.1454
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0608 0.0715
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0132 0.0155
Schistosoma mansoni hypothetical protein 0.0309 0.149 1
Trypanosoma brucei alpha tubulin 0.026 0.1237 0.4665
Loa Loa (eye worm) hypothetical protein 0.0025 0.0018 0.0123
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0077 0.0107
Echinococcus multilocularis Tubulin beta 2C chain 0.014 0.0615 0.0723
Echinococcus multilocularis peregrin 0.0028 0.0037 0.0043
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0061 0.0204 0.5
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.0394 0.0463
Schistosoma mansoni tubulin subunit beta 0.014 0.0615 0.4126
Brugia malayi Tubulin beta chain 0.0079 0.03 0.0414
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0094 0.0111
Entamoeba histolytica hypothetical protein 0.0038 0.0085 0.0687
Plasmodium vivax tubulin alpha chain, putative 0.026 0.1237 0.4665
Mycobacterium leprae cell division protein FtsZ 0.0061 0.0204 1
Schistosoma mansoni hypothetical protein 0.0047 0.0132 0.0886
Trypanosoma cruzi tubulin delta chain 0.0061 0.0204 0.0771
Trichomonas vaginalis tubulin alpha chain, putative 0.014 0.0615 0.497
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0125 0.1012
Giardia lamblia Beta tubulin 0.014 0.0615 0.2319
Brugia malayi CHE-14 protein 0.0044 0.0119 0.0164
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0119 0.0799
Echinococcus multilocularis tubulin gamma 1 chain 0.014 0.0615 0.0723
Loa Loa (eye worm) alpha-tubulin 0.026 0.1237 0.8301
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0067 0.0452
Plasmodium falciparum tubulin delta chain, putative 0.0061 0.0204 0.0771
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0132 0.0886
Echinococcus multilocularis protein dispatched 1 0.005 0.0151 0.0178
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0067 0.0452
Plasmodium falciparum alpha tubulin 2 0.026 0.1237 0.4665
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0797 0.6442
Entamoeba histolytica tubulin gamma chain 0.014 0.0615 0.497
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0223 0.0263
Plasmodium falciparum tubulin gamma chain 0.014 0.0615 0.2319
Trypanosoma brucei beta tubulin 0.014 0.0615 0.2319
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0365 0.2955
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.0377 0.0444
Loa Loa (eye worm) BEN-1 protein 0.014 0.0615 0.4126
Leishmania major beta tubulin 0.014 0.0615 0.2319
Echinococcus granulosus peregrin 0.0028 0.0037 0.0245
Echinococcus granulosus beta tubulin 0.014 0.0615 0.4126
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0067 0.0452
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0132 0.0886
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0223 0.15
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0011 0.0091
Trichomonas vaginalis tubulin epsilon chain, putative 0.014 0.0615 0.497
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0119 0.0799
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0021 0.0078
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0037 0.0245
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.004 0.0149
Leishmania major hypothetical protein, conserved 0.0025 0.0021 0.0078
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0656 0.4401
Schistosoma mansoni tubulin subunit beta 0.014 0.0615 0.4126
Leishmania major alpha tubulin 0.026 0.1237 0.4665
Loa Loa (eye worm) tubulin alpha-3 chain 0.0181 0.0827 0.5548
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.149 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0061 0.0204 0.1653
Echinococcus multilocularis tubulin alpha 0.014 0.0615 0.0723

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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