Detailed information for compound 1665985

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 255.269 | Formula: C15H13NO3
  • H donors: 1 H acceptors: 1 LogP: 3.21 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1cc2c(cc1OC)[nH]c1c2cccc1
  • InChi: 1S/C15H13NO3/c1-18-14-8-13-10(7-11(14)15(17)19-2)9-5-3-4-6-12(9)16-13/h3-8,16H,1-2H3
  • InChiKey: BYDOYRHWHKPKQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.002 0.002 0.002
Brugia malayi MBOAT family protein 0.0369 0.0836 0.0836
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0016 0.0016
Entamoeba histolytica hypothetical protein 0.0018 0.0016 0.0182
Trypanosoma brucei unspecified product 0.0013 0.0002 0.0025
Echinococcus multilocularis regulator of G protein signaling 3 0.0018 0.0016 0.0015
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0014 0.0014
Loa Loa (eye worm) MBOAT family protein 0.4282 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0016
Brugia malayi PXA domain containing protein 0.0018 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0243 0.0542 0.0542
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0006 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0003 0.0037
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0068 0.0811
Brugia malayi Regulator of G protein signaling domain containing protein 0.0018 0.0016 0.0015
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0018 0.0016 0.0016
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0369 0.0836 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0098 0.0098
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0295 0.3521
Trypanosoma brucei unspecified product 0.0013 0.0002 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0037
Entamoeba histolytica hypothetical protein 0.0369 0.0836 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0057 0.0828
Echinococcus multilocularis axis inhibition protein axin 0.0018 0.0016 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0187
Mycobacterium tuberculosis Conserved hypothetical protein 0.0153 0.0331 0.6306
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0017 0.0017
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0057 0.0828
Schistosoma mansoni ran 0.002 0.002 0.002
Brugia malayi MBOAT family protein 0.0369 0.0836 0.0836
Schistosoma mansoni lipoxygenase 0.0019 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0187
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0006 0.0006
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0016 0.0016
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0016 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0187
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.002 0.002 0.0238
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0057 0.0057
Trichomonas vaginalis ran, putative 0.002 0.002 0.0238
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0016 0.0015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0003 0.0037
Mycobacterium tuberculosis Conserved protein 0.0036 0.0057 0.0828
Loa Loa (eye worm) hypothetical protein 0.0036 0.0057 0.0057
Echinococcus granulosus cpg binding protein 0.0062 0.0117 0.0117
Giardia lamblia DINP protein human, muc B family 0.0019 0.0016 0.2816
Loa Loa (eye worm) hypothetical protein 0.0036 0.0057 0.0057
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0068 0.0811
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0018 0.0016 0.0016
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0056 0.0056
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0057 0.0828
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0016 0.0187
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0003 0.0037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0016
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0056 0.0666
Loa Loa (eye worm) beta-lactamase 0.0036 0.0057 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0037
Echinococcus granulosus regulator of G protein signaling 3 0.0018 0.0016 0.0015
Leishmania major glycerol uptake protein, putative 0.0369 0.0836 1
Schistosoma mansoni cpg binding protein 0.0062 0.0117 0.0117
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.011 0.011
Leishmania major DNA polymerase eta, putative 0.003 0.0044 0.0517
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0098 0.0098
Brugia malayi regulator of G-protein signaling rgs-7 0.0018 0.0016 0.0015
Schistosoma mansoni microtubule-associated protein tau 0.0665 0.1529 0.1529
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0369 0.0836 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0263 0.0263
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0369 0.0836 0.0836
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0006 0.0006
Echinococcus granulosus microtubule associated protein 2 0.0665 0.1529 0.1528
Schistosoma mansoni hypothetical protein 0.0346 0.0782 0.0782
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0016 0.0016
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.002 0.002 0.0238
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0369 0.0836 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.011 0.2974
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0017 0.0017
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0074 0.0877
Loa Loa (eye worm) RGS-3 protein 0.0018 0.0016 0.0016
Echinococcus multilocularis GTP binding nuclear protein Ran 0.002 0.002 0.002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0057 0.0057
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0018 0.0016 0.0016
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0016 0.0015
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0369 0.0836 0.0836
Brugia malayi hypothetical protein 0.0018 0.0016 0.0015
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0006 0.0006
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0012 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0187
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0089 0.1061
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0018 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0043 0.0074 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0182
Echinococcus multilocularis GPCR, family 2 0.0017 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0037
Onchocerca volvulus 0.0036 0.0057 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0369 0.0836 1
Echinococcus multilocularis expressed protein 0.0359 0.0814 0.0814
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0037
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0018 0.0016 0.0016
Echinococcus granulosus axis inhibition protein axin 0.0018 0.0016 0.0015
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0018 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0016
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0056 0.0056
Brugia malayi CXXC zinc finger family protein 0.0059 0.011 0.0109
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0369 0.0836 0.0836
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0369 0.0836 0.0836
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0057 0.0828
Toxoplasma gondii ImpB/MucB/SamB family protein 0.003 0.0044 0.0517
Toxoplasma gondii hypothetical protein 0.0047 0.0082 0.0979
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0056 0.0056
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0002 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0187
Echinococcus multilocularis zinc finger protein 0.3913 0.9136 0.9136
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0002 0.0025
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.002 0.002 0.357
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.4282 1 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0099 0.0098
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.0502 0.0502
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0012
Trypanosoma cruzi GUP1, putative 0.0369 0.0836 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0018 0.0016 0.0016
Brugia malayi Hhat protein 0.0369 0.0836 0.0836
Trypanosoma cruzi glycerol uptake protein, putative 0.0369 0.0836 1
Echinococcus granulosus sterol O acyltransferase 1 0.0369 0.0836 0.0836
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0291 0.0653 0.7811
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0187
Leishmania major DNA polymerase kappa, putative 0.0019 0.0016 0.0187
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0057 0.0682
Echinococcus multilocularis cpg binding protein 0.0062 0.0117 0.0117
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0056 0.0666
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0056 0.0666
Loa Loa (eye worm) MBOAT family protein 0.0369 0.0836 0.0836
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0017
Echinococcus granulosus snurportin 1 0.0296 0.0667 0.0666
Brugia malayi PXA domain containing protein 0.0018 0.0016 0.0015
Echinococcus multilocularis sterol O acyltransferase 1 0.0369 0.0836 0.0836
Schistosoma mansoni z-protein (S1r protein) 0.0018 0.0016 0.0016
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.011 0.0109
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.0187
Schistosoma mansoni hypothetical protein 0.0346 0.0782 0.0782
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0068 0.0811
Schistosoma mansoni polycystin 1-related 0.0019 0.0017 0.0017
Echinococcus granulosus expressed protein 0.0359 0.0814 0.0814
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.002 0.002 0.0238
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0295 0.3521
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0016 0.0016
Echinococcus granulosus o acyltransferase membrane bound domain 0.0369 0.0836 0.0836
Echinococcus granulosus beta-adrenergic receptor kinase 0.0018 0.0016 0.0015
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.0187
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0057 0.0682
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0058 0.0058
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0057 0.0057
Treponema pallidum alginate O-acetylation protein (algI) 0.0369 0.0836 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.011 0.2974
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0187
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0056 0.0666
Brugia malayi A-kinase anchor protein 10, precursor 0.0018 0.0016 0.0015
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0037
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0012
Plasmodium falciparum importin beta, putative 0.0028 0.0037 0.0443
Echinococcus multilocularis Regulator of G protein signaling 20 0.0018 0.0016 0.0015
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0369 0.0836 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0025 0.0296
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0037 0.0058 0.0058
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0291 0.0653 0.7811
Entamoeba histolytica hypothetical protein 0.0018 0.0016 0.0182
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0057 0.0682
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.011 0.0109
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0012 0.0012
Schistosoma mansoni axis inhibition protein axin 0.0018 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0187
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0057 0.1313
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0017 0.0204
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.011 0.2974
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0056 0.0056
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0369 0.0836 0.0836
Trichomonas vaginalis conserved hypothetical protein 0.0369 0.0836 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0016
Brugia malayi beta-lactamase family protein 0.0036 0.0057 0.0057
Brugia malayi beta-lactamase family protein 0.0036 0.0057 0.0057
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.002 0.002 0.0238
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0018 0.0016 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0182
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0057 0.0682
Loa Loa (eye worm) hypothetical protein 0.0369 0.0836 0.0836
Trichomonas vaginalis transmembrane protein nessy, putative 0.0369 0.0836 1
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0016 0.0016
Echinococcus multilocularis geminin 0.0346 0.0782 0.0781
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0017 0.0017
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0006 0.0006
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0036 0.0057 0.0057
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0187
Echinococcus granulosus importin subunit beta 1 0.0028 0.0037 0.0037
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0369 0.0836 0.0836
Brugia malayi Cytochrome P450 family protein 0.0047 0.0083 0.0082
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.002 0.002 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0182
Trichomonas vaginalis porcupine, putative 0.0369 0.0836 1
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0369 0.0836 0.0836
Schistosoma mansoni importin beta-1 0.0028 0.0037 0.0037
Echinococcus granulosus dna polymerase kappa 0.0019 0.0016 0.0016
Schistosoma mansoni cpg binding protein 0.0062 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0834 0.1926 0.1926
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0037 0.0443
Loa Loa (eye worm) hypothetical protein 0.0036 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0369 0.0836 0.0836
Schistosoma mansoni lipoxygenase 0.0054 0.0099 0.0099
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0074 0.0073
Brugia malayi hypothetical protein 0.0019 0.0017 0.0017
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0056 0.0056
Echinococcus multilocularis regulator of G protein signaling 3 0.0018 0.0016 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0187
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0187
Loa Loa (eye worm) hypothetical protein 0.0054 0.0098 0.0098
Echinococcus multilocularis dnaJ subfamily B 0.0834 0.1926 0.1925
Onchocerca volvulus Huntingtin homolog 0.0243 0.0542 0.6401
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0037
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0056 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0827 0.1909 0.1909
Mycobacterium ulcerans lipase LipD 0.0036 0.0057 0.1313
Echinococcus granulosus axis inhibition protein axin 0.0018 0.0016 0.0015
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0056 0.0056
Brugia malayi beta-lactamase 0.0036 0.0057 0.0057
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0016 0.0016
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0025 0.0296
Brugia malayi regulator of G-protein signaling egl-10 0.0018 0.0016 0.0015
Brugia malayi Importin beta-1 subunit 0.0028 0.0037 0.0037
Entamoeba histolytica hypothetical protein, conserved 0.0369 0.0836 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0369 0.0836 1
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0057 0.0828
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.0044 0.0517
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0003 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0057 0.0682
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0182
Echinococcus granulosus GTP binding nuclear protein Ran 0.002 0.002 0.002
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0037 0.0037
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0083 0.0083
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0016 0.0187
Loa Loa (eye worm) hypothetical protein 0.0369 0.0836 0.0836
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0182
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0057 0.0682
Brugia malayi MBOAT family protein 0.0369 0.0836 0.0836
Leishmania major glycerol uptake protein, putative 0.0369 0.0836 1
Echinococcus granulosus GPCR family 2 0.0017 0.0012 0.0012
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0025 0.0296
Leishmania major glycerol uptake protein, putative 0.0369 0.0836 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0056 0.0056
Leishmania major mitochondrial DNA polymerase beta 0.0291 0.0653 0.7811
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0016 0.0016
Echinococcus multilocularis axis inhibition protein axin 0.0018 0.0016 0.0015
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0074 0.0877
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0369 0.0836 0.0836
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0003 0.0037
Echinococcus granulosus zinc finger protein 0.3913 0.9136 0.9136
Entamoeba histolytica hypothetical protein 0.0018 0.0016 0.0182
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.0017
Echinococcus granulosus o acyltransferase membrane bound domain 0.0369 0.0836 0.0836
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0012 0.0012
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.0516 1
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0016 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0016 0.0016
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0369 0.0836 0.0836
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0057 0.0682
Leishmania major GTP-binding protein, putative 0.002 0.002 0.0238
Brugia malayi diacylglycerol acyltransferase 0.0369 0.0836 0.0836
Entamoeba histolytica vacuolar protein sorting 26 0.0369 0.0836 1
Leishmania major hypothetical protein, conserved 0.0036 0.0057 0.0682
Trypanosoma cruzi GUP1, putative 0.0369 0.0836 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0016 0.0187
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0057 0.0682
Echinococcus granulosus geminin 0.0346 0.0782 0.0781
Echinococcus multilocularis microtubule associated protein 2 0.0665 0.1529 0.1528
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0187
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.0037
Plasmodium vivax importin-beta 2, putative 0.0028 0.0037 0.0443
Trypanosoma brucei glycerol uptake protein, putative 0.0369 0.0836 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0056 0.0056
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0056 0.0666
Schistosoma mansoni axis inhibition protein axin 0.0018 0.0016 0.0016
Echinococcus granulosus Regulator of G protein signaling 20 0.0018 0.0016 0.0015
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.0295 0.3521
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0018 0.0016 0.0016
Toxoplasma gondii ABC1 family protein 0.0036 0.0057 0.0682
Leishmania major glycerol uptake protein, putative 0.0369 0.0836 1
Echinococcus granulosus RUN 0.0019 0.0017 0.0017
Mycobacterium ulcerans hypothetical protein 0.0153 0.0331 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0012 0.0012
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0098 0.0098
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0016 0.0016
Schistosoma mansoni rab6-interacting 0.0019 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0037 0.0058 0.0058
Entamoeba histolytica Ran family GTPase 0.002 0.002 0.0238
Brugia malayi RNA, U transporter 1 0.0079 0.0157 0.0157
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0057 0.5
Loa Loa (eye worm) hhat protein 0.0369 0.0836 0.0836
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0068 0.0811
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0016 0.0015
Onchocerca volvulus 0.0059 0.011 0.1124
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0369 0.0836 0.0836
Echinococcus granulosus dnaJ subfamily B 0.0834 0.1926 0.1925
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0037
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0369 0.0836 0.0836
Schistosoma mansoni rab6-interacting 0.0019 0.0017 0.0017
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0369 0.0836 0.0836
Mycobacterium tuberculosis Conserved protein 0.0036 0.0057 0.0828
Loa Loa (eye worm) hypothetical protein 0.0243 0.0542 0.0542
Leishmania major glycerol uptake protein, putative 0.0369 0.0836 1
Trypanosoma brucei glycerol uptake protein, putative 0.0369 0.0836 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0015 0.0014
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0037 0.0443
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0036 0.0057 0.0057
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0296 0.0667 0.0667
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0369 0.0836 0.0836
Loa Loa (eye worm) hypothetical protein 0.0036 0.0057 0.0057
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0003 0.0037
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0056 0.0666
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0025 0.0296
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.4282 1 1
Echinococcus multilocularis regulator of G protein signaling 0.0018 0.0016 0.0015
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0012
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0017 0.0017
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0057 0.0057
Schistosoma mansoni zinc finger protein 0.4282 1 1
Leishmania major hypothetical protein, conserved 0.0369 0.0836 1
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0369 0.0836 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0099 0.0098
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.002 0.002 0.002
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0016 0.0015
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0017 0.0204
Entamoeba histolytica hypothetical protein 0.0023 0.0025 0.0296
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0018 0.0016 0.0182
Schistosoma mansoni DNA polymerase eta 0.0043 0.0074 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0056 0.0666
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.011 0.011
Echinococcus granulosus dna polymerase eta 0.0043 0.0074 0.0073
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0012
Brugia malayi hypothetical protein 0.0019 0.0017 0.0017
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0003 0.0037
Trichomonas vaginalis helicase, putative 0.0013 0.0003 0.0037
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.011 0.1308
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0369 0.0836 0.0836
Leishmania major DNA polymerase eta, putative 0.0043 0.0074 0.0877
Echinococcus multilocularis dna polymerase eta 0.0043 0.0074 0.0073
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0057 0.0057
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0012 0.0012
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0057 0.1313
Loa Loa (eye worm) MBOAT family protein 0.0369 0.0836 0.0836
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0003 0.0037
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0369 0.0836 0.0836
Onchocerca volvulus 0.0036 0.0057 0.0488
Echinococcus multilocularis beta adrenergic receptor kinase 0.0018 0.0016 0.0015
Echinococcus granulosus o acyltransferase membrane bound domain 0.0369 0.0836 0.0836
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0187
Brugia malayi Regulator of G protein signaling domain containing protein 0.0018 0.0016 0.0015
Brugia malayi Doublecortin family protein 0.0019 0.0017 0.0017
Schistosoma mansoni ran 0.002 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0369 0.0836 0.0836
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0057 0.0057
Echinococcus granulosus regulator of G protein signaling 3 0.0018 0.0016 0.0015
Echinococcus multilocularis RUN 0.0019 0.0017 0.0017
Trichomonas vaginalis esterase, putative 0.0036 0.0057 0.0682
Brugia malayi MBOAT family protein 0.0369 0.0836 0.0836
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.0187
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0016 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0037
Schistosoma mansoni cpg binding protein 0.0059 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.011 0.011
Schistosoma mansoni loxhd1 0.0019 0.0017 0.0017
Loa Loa (eye worm) PXA domain-containing protein 0.0018 0.0016 0.0016
Mycobacterium ulcerans hypothetical protein 0.0036 0.0057 0.1313
Leishmania major importin beta-1 subunit, putative 0.0023 0.0025 0.0296
Onchocerca volvulus Huntingtin homolog 0.0243 0.0542 0.6401
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0015 0.0015
Schistosoma mansoni sterol O-acyltransferase 1 0.0369 0.0836 0.0836
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0037 0.0443
Loa Loa (eye worm) hhat protein 0.0369 0.0836 0.0836
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0369 0.0836 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0291 0.0653 0.7811
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0057 0.0828
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0017
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0369 0.0836 1
Brugia malayi hypothetical protein 0.0243 0.0542 0.0541
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0369 0.0836 0.0836
Mycobacterium tuberculosis Conserved protein 0.0036 0.0057 0.0828
Echinococcus multilocularis snurportin 1 0.0296 0.0667 0.0666
Toxoplasma gondii hypothetical protein 0.0369 0.0836 1
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0369 0.0836 0.0836
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0056 0.0056
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.002 0.002 0.0238
Onchocerca volvulus 0.0369 0.0836 1
Trypanosoma brucei unspecified product 0.0019 0.0016 0.0187
Mycobacterium leprae Probable lipase LipE 0.0036 0.0057 0.5
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0057 0.0682
Brugia malayi hypothetical protein 0.0018 0.0016 0.0015
Schistosoma mansoni hypothetical protein 0.0296 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0036 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0056 0.0666
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0015 0.0014
Brugia malayi follicle stimulating hormone receptor 0.0226 0.0502 0.0501
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0369 0.0836 0.0836
Trichomonas vaginalis conserved hypothetical protein 0.0369 0.0836 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0369 0.0836 1
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0369 0.0836 0.0836
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0002 0.0025
Mycobacterium ulcerans beta-lactamase 0.0036 0.0057 0.1313
Onchocerca volvulus 0.0036 0.0057 0.0488
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.011 0.1308
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.011 0.1875
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0016 0.0016
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0057 0.0828
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0016 0.0016
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0182
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.0232 0.2773
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0369 0.0836 0.0836

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 128 ug ml-1 Antibacterial activity against Escherichia coli TISTR 780 by broth dilution method ChEMBL. 22482432

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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