Detailed information for compound 169394

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 888.11 | Formula: C46H69N11O7
  • H donors: 9 H acceptors: 6 LogP: 2.47 Rotable bonds: 27
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC[C@@H]([C@@H](C(=O)OC)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@]1(CC1CN1CC[C@@]2(C(C1Cc1c2cc(cc1)O)C)C)c1ccccc1)CCCN=C(N)N)CCCN=C(N)N)C
  • InChi: 1S/C46H69N11O7/c1-6-27(2)38(41(62)64-5)56-40(61)35(15-11-20-52-44(49)50)55-39(60)34(14-10-19-51-43(47)48)54-37(59)25-53-42(63)46(30-12-8-7-9-13-30)24-31(46)26-57-21-18-45(4)28(3)36(57)22-29-16-17-32(58)23-33(29)45/h7-9,12-13,16-17,23,27-28,31,34-36,38,58H,6,10-11,14-15,18-22,24-26H2,1-5H3,(H,53,63)(H,54,59)(H,55,60)(H,56,61)(H4,47,48,51)(H4,49,50,52)/t27-,28?,31?,34-,35-,36?,38-,45+,46-/m0/s1
  • InChiKey: WOIBVWASKSGEPH-GXHJSZMMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Mu opioid receptor Starlite/ChEMBL References
Cavia porcellus Kappa opioid receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Kappa opioid receptor   380 aa 313 aa 26.2 %
Echinococcus multilocularis growth hormone secretagogue receptor type 1 Kappa opioid receptor   380 aa 306 aa 21.2 %
Echinococcus granulosus somatostatin receptor Kappa opioid receptor   380 aa 342 aa 19.6 %
Echinococcus granulosus thyrotropin releasing hormone receptor Mu opioid receptor   398 aa 370 aa 27.3 %
Brugia malayi hypothetical protein Kappa opioid receptor   380 aa 320 aa 20.6 %
Onchocerca volvulus Phospholipase d-related homolog Kappa opioid receptor   380 aa 326 aa 20.9 %
Schistosoma japonicum Rhodopsin, putative Mu opioid receptor   398 aa 328 aa 23.2 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Mu opioid receptor   398 aa 397 aa 22.7 %
Onchocerca volvulus Mu opioid receptor   398 aa 333 aa 26.4 %
Echinococcus granulosus allatostatin A receptor Mu opioid receptor   398 aa 346 aa 29.5 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Mu opioid receptor   398 aa 334 aa 23.1 %
Brugia malayi GnHR receptor homolog Kappa opioid receptor   380 aa 341 aa 20.2 %
Schistosoma mansoni rhodopsin-like orphan GPCR Kappa opioid receptor   380 aa 379 aa 22.4 %
Onchocerca volvulus Mu opioid receptor   398 aa 376 aa 26.3 %
Onchocerca volvulus Kappa opioid receptor   380 aa 310 aa 24.2 %
Onchocerca volvulus Phosphoinositide 3-kinase adapter subunit homolog Kappa opioid receptor   380 aa 323 aa 22.6 %
Schistosoma mansoni neuropeptide F-like receptor Mu opioid receptor   398 aa 335 aa 20.6 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Mu opioid receptor   398 aa 334 aa 24.9 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Mu opioid receptor   398 aa 371 aa 27.0 %
Onchocerca volvulus Programmed cell death protein 5 homolog Mu opioid receptor   398 aa 323 aa 24.1 %
Onchocerca volvulus Mitogen-activated protein kinase kinase kinase 8 homolog Kappa opioid receptor   380 aa 395 aa 20.3 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Kappa opioid receptor   380 aa 352 aa 20.2 %
Brugia malayi hypothetical protein Kappa opioid receptor   380 aa 319 aa 21.6 %
Brugia malayi ORL1-like opioid receptor Kappa opioid receptor   380 aa 312 aa 25.3 %
Echinococcus multilocularis allatostatin A receptor Mu opioid receptor   398 aa 341 aa 29.3 %
Onchocerca volvulus Mu opioid receptor   398 aa 356 aa 23.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptides capa receptor 0.0008 0.0043 0.009
Brugia malayi Dopamine receptor protein 1 0.0008 0.0043 0.0122
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0012 0.0117 0.2182
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0414 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Loa Loa (eye worm) hypothetical protein 0.0025 0.038 0.162
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0013 0.0145 0.0574
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0269 0.1125
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.038 0.1187
Plasmodium vivax hexose transporter 0.012 0.2266 0.2253
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Echinococcus granulosus General substrate transporter 0.0103 0.193 0.6237
Leishmania major protein kinase, putative 0.0037 0.0611 0.855
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0043 0.009
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.038 0.1185
Echinococcus granulosus 7tm_1 domain containing protein 0.0008 0.0043 0.009
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.038 0.162
Echinococcus multilocularis neuropeptides capa receptor 0.0008 0.0043 0.009
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.2266 0.7329
Echinococcus granulosus neuropeptide receptor 0.0008 0.0043 0.009
Onchocerca volvulus Putative transporter 0.0017 0.0217 0.5152
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0007 0.0016 0.0262
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0117 0.0329
Onchocerca volvulus 0.0025 0.038 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0008 0.0043 0.009
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0715 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0008 0.0043 0.009
Brugia malayi hypothetical protein 0.0008 0.0043 0.0122
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0007 0.0016 0.0377
Plasmodium falciparum protein kinase 7 0.034 0.6617 0.6612
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0007 0.0016 0.0218
Leishmania major hypothetical protein, conserved 0.0017 0.0217 0.303
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.0043 0.009
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0043 0.0122
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Echinococcus granulosus neuropeptide s receptor 0.0008 0.0043 0.009
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0008 0.0043 0.0122
Brugia malayi sulfakinin receptor protein 0.0008 0.0043 0.0122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.038 0.1185
Loa Loa (eye worm) hypothetical protein 0.0017 0.0217 0.0894
Brugia malayi GnHR receptor homolog 0.0008 0.0043 0.0122
Schistosoma mansoni neuropeptide receptor 0.0008 0.0043 0.009
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0621 0.868
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0621 0.868
Plasmodium vivax sugar transporter, putative 0.0017 0.0217 0.0201
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.038 0.1187
Loa Loa (eye worm) sugar transporter 0.012 0.2266 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Brugia malayi Serotonin receptor 0.0008 0.0043 0.0122
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0269 0.3758
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Brugia malayi Tachykinin-like peptides receptor 99D 0.0008 0.0043 0.0122
Brugia malayi follicle stimulating hormone receptor 0.0008 0.0043 0.0122
Schistosoma mansoni sugar transporter 0.0017 0.0217 0.0655
Brugia malayi hypothetical protein 0.0017 0.0217 0.0894
Brugia malayi hypothetical protein 0.0013 0.0145 0.0574
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0414 0.1296
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0043 0.009
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0414 0.1296
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0043 0.009
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0715 1
Brugia malayi hypothetical protein 0.0008 0.0043 0.0122
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0269 0.6499
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0043 0.009
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Plasmodium falciparum calcium-dependent protein kinase 2 0.0037 0.0612 0.0597
Loa Loa (eye worm) hypothetical protein 0.0012 0.0117 0.0449
Echinococcus granulosus neuropeptide Y receptor 0.0008 0.0043 0.009
Echinococcus multilocularis neuropeptide receptor 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0217 0.0894
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0043 0.009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0269 0.3758
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.012 0.2266 0.7317
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.0333 1
Brugia malayi Melatonin receptor type 1A 0.0008 0.0043 0.0122
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0043 0.0122
Plasmodium falciparum calcium-dependent protein kinase 4 0.0037 0.0612 0.0597
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0012 0.0117 0.0329
Loa Loa (eye worm) hypothetical protein 0.0013 0.0145 0.0574
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.0043 0.009
Echinococcus granulosus transient receptor potential cation channel 0.0161 0.3086 1
Echinococcus multilocularis solute carrier family 22 0.0017 0.0217 0.0654
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0333 0.5587
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Brugia malayi tailless protein 0.0012 0.0117 0.0449
Echinococcus multilocularis dro:myosuppressin receptor 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0597 0.2583
Schistosoma mansoni opsin-like receptor 0.0008 0.0043 0.009
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0012 0.0117 0.0449
Trypanosoma cruzi glucose transporter, putative 0.0017 0.0217 0.303
Toxoplasma gondii sugar transporter ST2 0.0017 0.0217 0.0327
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.038 0.1187
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.038 0.162
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Plasmodium falciparum mitogen-activated protein kinase 2 0.0194 0.3734 0.3724
Schistosoma mansoni ap endonuclease 0.002 0.0269 0.0825
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0025 0.038 0.162
Loa Loa (eye worm) hypothetical protein 0.0017 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Plasmodium falciparum calcium-dependent protein kinase 3 0.0037 0.0612 0.0597
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Trypanosoma brucei glucose transporter 2A 0.0037 0.0621 0.868
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0611 0.1938
Trypanosoma brucei sugar transporter, putative 0.0017 0.0217 0.303
Loa Loa (eye worm) hypothetical protein 0.0012 0.0117 0.0449
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.0134 0.4681
Echinococcus granulosus 7TM GPCR rhodopsin 0.0008 0.0043 0.009
Loa Loa (eye worm) sugar transporter 0.0017 0.0217 0.0894
Echinococcus multilocularis allatostatin A receptor 0.0008 0.0043 0.009
Schistosoma mansoni hypothetical protein 0.0008 0.0043 0.009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0043 0.009
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0597 0.1893
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0037 0.0611 0.2648
Echinococcus granulosus neuropeptide FF receptor 2 0.0008 0.0043 0.009
Loa Loa (eye worm) nuclear receptor NHR-67 0.0012 0.0117 0.0449
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0043 0.009
Leishmania major glucose transporter, lmgt3 0.0037 0.0621 0.868
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0043 0.0122
Loa Loa (eye worm) hypothetical protein 0.0017 0.0217 0.0894
Mycobacterium ulcerans integral membrane transport protein 0.0017 0.0217 0.5239
Plasmodium falciparum hexose transporter 0.012 0.2266 0.2253
Echinococcus granulosus orexin receptor type 2 0.0008 0.0043 0.009
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.038 0.162
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0037 0.0612 0.0925
Schistosoma mansoni hypothetical protein 0.012 0.2266 0.7329
Echinococcus granulosus FTZ F1 alpha 0.0025 0.038 0.1187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0043 0.009
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0621 0.274
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0621 0.274
Schistosoma mansoni amine GPCR 0.0008 0.0043 0.009
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Schistosoma mansoni biogenic amine receptor 0.0008 0.0043 0.009
Echinococcus granulosus solute carrier family 22 0.0017 0.0217 0.0655
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.038 0.162
Echinococcus granulosus calcium dependent protein kinase 0.0035 0.0566 0.1794
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0013 0.0145 0.0421
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0017 0.0217 0.6499
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Brugia malayi ecdysone receptor 0.0012 0.0117 0.0449
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0036 0.0597 0.2634
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0621 0.274
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0117 0.0449
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0414 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0012 0.0117 0.0449
Echinococcus multilocularis G-protein coupled receptor, putative 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0117 0.0449
Schistosoma mansoni histamine h1 receptor 0.0008 0.0043 0.009
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.038 0.162
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.038 0.1187
Schistosoma mansoni amine GPCR 0.0008 0.0043 0.009
Echinococcus granulosus neuropeptides capa receptor 0.0008 0.0043 0.009
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0008 0.0043 0.0122
Loa Loa (eye worm) hypothetical protein 0.0017 0.0217 0.0894
Schistosoma mansoni protein kinase 0.0037 0.0611 0.1941
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0036 0.0597 0.9752
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Echinococcus granulosus biogenic amine 5HT receptor 0.0008 0.0043 0.009
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0007 0.0016 0.0377
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Trypanosoma brucei glucose transporter, putative 0.0037 0.0621 0.868
Echinococcus granulosus ankyrin repeat protein 0.0161 0.3086 1
Toxoplasma gondii protein kinase, putative 0.034 0.6617 1
Brugia malayi hypothetical protein 0.0008 0.0043 0.0122
Loa Loa (eye worm) hypothetical protein 0.0037 0.0611 0.2648
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0621 0.274
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0017 0.0217 0.0655
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.038 0.162
Onchocerca volvulus Protein ultraspiracle homolog 0.0025 0.038 1
Plasmodium falciparum proline--tRNA ligase 0.0042 0.0715 0.0701
Loa Loa (eye worm) hypothetical protein 0.0017 0.0217 0.0894
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0017 0.0217 0.303
Onchocerca volvulus 0.0017 0.0217 0.5152
Echinococcus multilocularis solute carrier family 22 0.0017 0.0217 0.0654
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.038 0.1187
Brugia malayi hypothetical protein 0.0008 0.0043 0.0122
Trypanosoma brucei glucose transporter, putative 0.0037 0.0621 0.868
Brugia malayi larval opioid receptor 0.0008 0.0043 0.0122
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0269 0.3758
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0008 0.0043 0.009
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0012 0.0117 0.0449
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0008 0.0043 0.009
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0025 0.038 0.162
Onchocerca volvulus 0.0012 0.0117 0.2182
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0269 0.4357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.038 0.162
Leishmania major glucose transporter, lmgt2 0.0037 0.0621 0.868
Brugia malayi hypothetical protein 0.0008 0.0043 0.0122
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0414 0.1769
Schistosoma mansoni biogenic amine receptor 0.0008 0.0043 0.009
Brugia malayi ORL1-like opioid receptor 0.0008 0.0043 0.0122
Echinococcus multilocularis g-protein coupled receptor 0.0008 0.0043 0.009
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0012 0.0117 0.0329
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.038 0.1185
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0012 0.0117 0.0329
Loa Loa (eye worm) hypothetical protein 0.0017 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0414 0.6932
Trypanosoma brucei glucose transporter, putative 0.0037 0.0621 0.868
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.038 0.1187
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0043 0.009
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Echinococcus multilocularis fmrfamide receptor 0.0008 0.0043 0.009
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0611 0.1938
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0043 0.009
Echinococcus multilocularis transient receptor potential cation channel 0.0162 0.309 1
Schistosoma mansoni glucose transporter 0.0017 0.0217 0.0655
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0017 0.0217 0.0201
Brugia malayi RE15519p 0.0008 0.0043 0.0122
Schistosoma mansoni myosin xvIII 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Brugia malayi Serotonin receptor 0.0008 0.0043 0.0122
Onchocerca volvulus 0.0017 0.0217 0.5152
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Echinococcus multilocularis neuropeptide FF receptor 2 0.0008 0.0043 0.009
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0463 0.1987
Echinococcus multilocularis orexin receptor type 2 0.0008 0.0043 0.009
Echinococcus multilocularis General substrate transporter 0.0103 0.193 0.6227
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0611 0.1938
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0043 0.009
Entamoeba histolytica protein kinase, putative 0.0037 0.0611 1
Echinococcus granulosus neuropeptide receptor 0.0008 0.0043 0.009
Toxoplasma gondii glycyl-tRNA synthetase 0.0007 0.0016 0.0024
Brugia malayi hypothetical protein 0.0008 0.0043 0.0122
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0013 0.0145 0.0574
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0611 0.1941
Echinococcus granulosus somatostatin receptor 0.0008 0.0043 0.009
Echinococcus granulosus solute carrier family 22 0.0017 0.0217 0.0655
Schistosoma mansoni glucose transport protein 0.012 0.2266 0.7329
Echinococcus multilocularis solute carrier family 22 0.0017 0.0217 0.0654
Leishmania major glucose transporter/membrane transporter D2, putative 0.0037 0.0621 0.868
Echinococcus multilocularis neuropeptide Y receptor 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0025 0.038 0.162
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0715 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0037 0.0612 0.0597
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0414 0.1296
Echinococcus multilocularis solute carrier family 22 0.0017 0.0217 0.0654
Onchocerca volvulus 0.0017 0.0217 0.5152
Echinococcus granulosus synaptic vesicle 2 protein 0.0017 0.0217 0.0655
Brugia malayi ecdysteroid receptor 0.0025 0.038 0.162
Trypanosoma brucei glucose transporter, putative 0.0037 0.0621 0.868
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0043 0.009
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0042 0.0715 0.1081
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0414 0.6849
Brugia malayi hypothetical protein 0.0017 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Loa Loa (eye worm) hypothetical protein 0.0017 0.0217 0.0894
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0414 0.1294
Brugia malayi hypothetical protein 0.0008 0.0043 0.0122
Onchocerca volvulus 0.0017 0.0217 0.5152
Schistosoma mansoni protein kinase 0.0037 0.0611 0.1941
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0043 0.009
Schistosoma mansoni hypothetical protein 0.0008 0.0043 0.009
Schistosoma mansoni neuropeptide receptor 0.0008 0.0043 0.009
Brugia malayi steroid hormone receptor 0.0025 0.038 0.162
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0017 0.0217 0.5239
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0008 0.0043 0.009
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0007 0.0016 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0621 0.274
Onchocerca volvulus 0.0017 0.0217 0.5152
Brugia malayi neuropeptide F receptor 0.0008 0.0043 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.038 0.162
Brugia malayi Cam kinase protein 1 0.0037 0.0611 0.2648
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.2266 0.7329
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0013 0.0145 0.042
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Onchocerca volvulus 0.0017 0.0217 0.5152
Schistosoma mansoni sugar transporter 0.0017 0.0217 0.0655
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.038 0.1185
Schistosoma mansoni thyroid hormone receptor 0.0025 0.038 0.1187
Plasmodium falciparum calcium-dependent protein kinase 1 0.0037 0.0612 0.0597
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0269 0.1187
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Loa Loa (eye worm) hypothetical protein 0.0036 0.0597 0.2583
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0008 0.0043 0.009
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0043 0.009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.038 0.162
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0043 0.009
Brugia malayi nuclear receptor RXR 0.0012 0.0117 0.0449
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0043 0.0122
Echinococcus granulosus solute carrier family 22 0.0017 0.0217 0.0655
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0269 0.0254
Brugia malayi putative neuropeptide receptor NPR1 0.0008 0.0043 0.0122
Echinococcus multilocularis synaptic vesicle 2 protein 0.0017 0.0217 0.0654
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Loa Loa (eye worm) hypothetical protein 0.0017 0.0217 0.0894
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0012 0.0117 0.0329
Echinococcus granulosus G protein coupled receptor 139 0.0008 0.0043 0.009
Schistosoma mansoni adenoreceptor 0.0008 0.0043 0.009
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0145 0.0574
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0008 0.0043 0.009
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0036 0.0597 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0217 0.0894
Trypanosoma cruzi hexose transporter, putative 0.002 0.0286 0.3994
Echinococcus multilocularis serotonin receptor 0.0008 0.0043 0.009
Echinococcus granulosus tachykinin peptides receptor 99D 0.0008 0.0043 0.009
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0008 0.0043 0.009
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.038 0.162
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0025 0.038 0.162
Trypanosoma brucei glucose transporter, putative 0.0037 0.0621 0.868
Onchocerca volvulus 0.0017 0.0217 0.5152
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.038 0.1187
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Brugia malayi orphan nuclear receptor NR2E1 0.0012 0.0117 0.0449
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0217 0.0956
Schistosoma mansoni thyroid hormone receptor 0.0025 0.038 0.1187
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0611 0.1941
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.2266 0.7329
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.038 0.162
Echinococcus multilocularis somatostatin receptor 0.0008 0.0043 0.009
Echinococcus multilocularis G protein coupled receptor 139 0.0008 0.0043 0.009
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0012 0.0117 0.0449
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0348 0.1536
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0414 0.5783
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0008 0.0043 0.009
Trichomonas vaginalis glucose transporter, putative 0.0017 0.0217 0.0956
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0117 0.0449
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0013 0.0145 0.0574
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.0134 0.3243
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.038 0.162
Chlamydia trachomatis proline--tRNA ligase 0.0013 0.0134 0.2978
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0008 0.0043 0.009
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.038 0.1185
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0194 0.3734 0.3724
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0037 0.0612 0.0597
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0161 0.3086 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.038 0.162
Echinococcus granulosus g protein coupled receptor 0.0008 0.0043 0.009
Brugia malayi hypothetical protein 0.0008 0.0043 0.0122
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.038 0.1187
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0008 0.0043 0.0122
Schistosoma mansoni biogenic amine receptor 0.0008 0.0043 0.009
Schistosoma mansoni opsin-like receptor 0.0008 0.0043 0.009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0043 0.009
Echinococcus multilocularis neuropeptide receptor 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Brugia malayi Sugar transporter family protein 0.0017 0.0217 0.0894
Toxoplasma gondii sugar transporter ST3 0.0017 0.0217 0.0327
Leishmania major glucose transporter, lmgt1 0.0037 0.0621 0.868
Echinococcus multilocularis serotonin receptor 0.0008 0.0043 0.009
Echinococcus granulosus allatostatin A receptor 0.0008 0.0043 0.009
Brugia malayi major facilitator superfamily protein 0.0017 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0611 0.1941
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0218
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Loa Loa (eye worm) hypothetical protein 0.0012 0.0117 0.0449
Echinococcus granulosus alpha 1A adrenergic receptor 0.0008 0.0043 0.009
Leishmania major threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0218
Trypanosoma brucei glucose transporter, putative 0.0037 0.0621 0.868
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0145 0.0574
Brugia malayi nuclear receptor NHR-88 0.0025 0.038 0.162
Brugia malayi G protein-coupled receptor F59B2.13 0.0008 0.0043 0.0122
Brugia malayi nuclear hormone receptor 0.0025 0.038 0.162
Echinococcus granulosus neuropeptide receptor A26 0.0008 0.0043 0.009
Onchocerca volvulus 0.0017 0.0217 0.5152
Echinococcus granulosus sex peptide receptor 0.0008 0.0043 0.009
Schistosoma mansoni opsin-like receptor 0.0008 0.0043 0.009
Toxoplasma gondii exonuclease III APE 0.002 0.0269 0.0406
Trypanosoma brucei glucose transporter 1E 0.0037 0.0621 0.868
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0194 0.3734 0.5643
Schistosoma mansoni amine GPCR 0.0008 0.0043 0.009
Schistosoma mansoni sugar transporter 0.0017 0.0217 0.0655
Echinococcus granulosus g protein coupled receptor 0.0008 0.0043 0.009
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0017 0.0217 0.7942
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0008 0.0043 0.009
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0008 0.0043 0.0122
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0037 0.0612 0.0925
Trichomonas vaginalis myo-inositol transporter, putative 0.0017 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Echinococcus multilocularis neuropeptide Y receptor 0.0008 0.0043 0.009
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0043 0.009
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0012 0.0117 0.0329
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0414 0.5783
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0715 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0008 0.0043 0.009
Schistosoma mansoni protein kinase 0.0037 0.0611 0.1941
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0069
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.038 0.1187
Onchocerca volvulus 0.0012 0.0117 0.2182
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.038 0.162
Loa Loa (eye worm) hypothetical protein 0.0013 0.0145 0.0574
Onchocerca volvulus 0.0017 0.0217 0.5152
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0715 1
Trypanosoma cruzi sugar transporter, putative 0.0017 0.0217 0.303
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0043 0.009
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.012 0.2266 0.7317
Loa Loa (eye worm) hypothetical protein 0.0017 0.0217 0.0894
Echinococcus granulosus nuclear receptor nhr 48 0.0012 0.0117 0.0329
Loa Loa (eye worm) hypothetical protein 0.0012 0.0117 0.0449
Plasmodium vivax CDK-related protein kinase 6, putative 0.051 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0008 0.0043 0.009
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.038 0.162
Echinococcus granulosus neuropeptide Y receptor 0.0008 0.0043 0.009
Trichomonas vaginalis conserved hypothetical protein 0.012 0.2266 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.038 0.1185
Brugia malayi hypothetical protein 0.0017 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Onchocerca volvulus 0.0017 0.0217 0.5152
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0217 0.303
Loa Loa (eye worm) hypothetical protein 0.0017 0.0217 0.0894
Brugia malayi hypothetical protein 0.0008 0.0043 0.0122
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0008 0.0043 0.009
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0414 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0008 0.0043 0.0122
Schistosoma mansoni ap endonuclease 0.002 0.0269 0.0825
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0269 0.0825
Brugia malayi major facilitator superfamily protein 0.0017 0.0217 0.0894
Schistosoma mansoni coup transcription factor 0.0025 0.038 0.1187
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0012 0.0117 0.2182
Brugia malayi G-protein coupled receptor 0.0008 0.0043 0.0122
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0008 0.0043 0.0122
Loa Loa (eye worm) melatonin receptor type 1A 0.0008 0.0043 0.0122
Loa Loa (eye worm) hypothetical protein 0.0025 0.038 0.162
Schistosoma mansoni neuropeptide f receptor 76f 0.0008 0.0043 0.009
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0037 0.0612 0.0925
Leishmania major myo-inositol/proton symporter (MIT) 0.0017 0.0217 0.303
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.038 0.162
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Schistosoma mansoni glucose transport protein 0.012 0.2266 0.7329
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0217 0.0894
Brugia malayi neuropeptide F receptor 0.0008 0.0043 0.0122
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0008 0.0043 0.009
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0269 0.4249
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.0612 0.0597
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0008 0.0043 0.009
Echinococcus granulosus biogenic amine 5HT receptor 0.0008 0.0043 0.009
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0611 0.2699
Trichomonas vaginalis sugar transport protein, putative 0.0017 0.0217 0.0956
Schistosoma mansoni neuropeptide receptor 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0025 0.038 0.162
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.038 0.162
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.038 0.162
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Brugia malayi AKH receptor 0.0008 0.0043 0.0122
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0017 0.0217 0.5239
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0269 0.1125
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0218
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0015 0.0175 0.0709
Echinococcus granulosus thyroid hormone receptor alpha 0.0012 0.0117 0.0329
Echinococcus granulosus dro:myosuppressin receptor 0.0008 0.0043 0.009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0117 0.0329
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0117 0.0449
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0037 0.0611 0.2648
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.038 0.162
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.038 0.1187
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0025 0.038 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0145 0.0574
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0043 0.009
Onchocerca volvulus Bile acid receptor homolog 0.0025 0.038 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Onchocerca volvulus 0.0017 0.0217 0.5152
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.038 0.1187
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0008 0.0043 0.0122
Loa Loa (eye worm) DR-78 0.0012 0.0117 0.0449
Schistosoma mansoni alpha-1 adrenergic receptor 0.0008 0.0043 0.009
Echinococcus granulosus fmrfamide receptor 0.0008 0.0043 0.009
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0037 0.0612 0.0597
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.038 0.162
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0269 0.1187
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Plasmodium vivax proline--tRNA ligase, putative 0.0042 0.0715 0.0701
Brugia malayi nuclear receptor RXR 0.0013 0.0145 0.0574
Brugia malayi Dopamine receptor 0.0008 0.0043 0.0122
Schistosoma mansoni amine GPCR 0.0008 0.0043 0.009
Mycobacterium ulcerans sugar transporter 0.0017 0.0217 0.5239
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0269 0.0823
Echinococcus multilocularis neuropeptides capa receptor 0.0008 0.0043 0.009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.038 0.162
Brugia malayi nuclear receptor NHR-88 0.0012 0.0117 0.0449
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Giardia lamblia Sugar-proton symporter 0.0017 0.0217 0.346
Schistosoma mansoni neuropeptide receptor 0.0008 0.0043 0.009
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0017 0.0217 0.6499
Brugia malayi Sugar transporter family protein 0.012 0.2266 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0117 0.0449
Echinococcus granulosus solute carrier family 22 0.0017 0.0217 0.0655
Loa Loa (eye worm) TYRA-2 protein 0.0008 0.0043 0.0122
Brugia malayi Sugar transporter family protein 0.0017 0.0217 0.0894
Schistosoma mansoni zinc finger protein 0.0012 0.0117 0.0329
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.038 0.1185
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.2266 0.7329
Echinococcus multilocularis ankyrin repeat protein 0.0161 0.3086 0.9984
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0037 0.0621 0.868
Plasmodium falciparum calcium-dependent protein kinase 5 0.0037 0.0612 0.0597
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0217 0.0894
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0008 0.0043 0.0122
Toxoplasma gondii transporter, major facilitator family protein 0.0017 0.0217 0.0327
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0269 0.3758
Echinococcus granulosus serotonin receptor 0.0008 0.0043 0.009
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0414 0.0399
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0218
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Brugia malayi nuclear hormone receptor family member nhr-6 0.0012 0.0117 0.0449
Schistosoma mansoni nuclear hormone receptor 0.0025 0.038 0.1187
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0008 0.0043 0.009
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0008 0.0043 0.009
Onchocerca volvulus 0.0017 0.0217 0.5152
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0037 0.0611 0.855
Schistosoma mansoni glucose transport protein 0.012 0.2266 0.7329
Onchocerca volvulus 0.0017 0.0217 0.5152
Schistosoma mansoni nuclear receptor nhr-48 0.0012 0.0117 0.0329
Loa Loa (eye worm) hypothetical protein 0.0012 0.0117 0.0449
Brugia malayi hypothetical protein 0.0012 0.0117 0.0449
Schistosoma mansoni hypothetical protein 0.0008 0.0043 0.009
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0621 0.274
Echinococcus multilocularis sex peptide receptor 0.0008 0.0043 0.009
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0621 0.868
Schistosoma mansoni nuclear receptor 0.0012 0.0117 0.0329
Toxoplasma gondii facilitative glucose transporter GT1 0.012 0.2266 0.3424
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.038 0.1187
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0217 0.0894
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0013 0.0145 0.0421
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0008 0.0043 0.0122
Loa Loa (eye worm) nuclear hormone receptor 0.0012 0.0117 0.0449
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.0043 0.009
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0036 0.0597 0.189
Entamoeba histolytica hypothetical protein 0.0027 0.0414 0.6679
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.012 0.2266 0.7317
Schistosoma mansoni growth hormone secretagogue receptor 0.0008 0.0043 0.009
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.012 0.2266 0.7317
Onchocerca volvulus 0.0017 0.0217 0.5152
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0036 0.0597 0.2583
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0017 0.0217 0.0654
Brugia malayi conserved hypotetical protein 0.0012 0.0117 0.0449
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.038 0.1185
Entamoeba histolytica protein kinase, putative 0.0037 0.0611 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0621 0.868
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0043 0.009
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0036 0.0597 0.1893
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0008 0.0043 0.0122
Schistosoma mansoni biogenic amine (5HT) receptor 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0117 0.0449
Loa Loa (eye worm) hypothetical protein 0.0012 0.0117 0.0449
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0037 0.0611 0.2648
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0145 0.0421
Loa Loa (eye worm) hypothetical protein 0.0012 0.0117 0.0449
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Echinococcus multilocularis fmrfamide receptor 0.0008 0.0043 0.009
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.038 0.162
Toxoplasma gondii sugar transporter ST1 0.0017 0.0217 0.0327
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0269 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0217 0.0894
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0611 0.1941
Loa Loa (eye worm) hypothetical protein 0.0025 0.038 0.162
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0217 0.0956
Echinococcus multilocularis neuropeptide s receptor 0.0008 0.0043 0.009
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0117 0.0329
Schistosoma mansoni amine GPCR 0.0008 0.0043 0.009
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.038 0.1185
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0414 0.5783
Giardia lamblia Hexose transporter 0.0017 0.0217 0.346
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0269 0.8063
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0008 0.0043 0.009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Brugia malayi G protein-coupled receptor 0.0008 0.0043 0.0122
Brugia malayi hypothetical protein 0.0013 0.0145 0.0574
Onchocerca volvulus 0.0017 0.0217 0.5152
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0414 0.1826
Echinococcus granulosus Sugar transporter ERD6 protein 0.0017 0.0217 0.0655
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0008 0.0043 0.009
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0117 0.0329
Brugia malayi G-protein coupled receptor 0.0008 0.0043 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0017 0.0217 0.0894
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0269 0.0254
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0043 0.009
Brugia malayi hypothetical protein 0.0008 0.0043 0.0122
Echinococcus granulosus g protein coupled receptor 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0122
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.038 0.162
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0037 0.0611 0.1941
Echinococcus multilocularis calcium dependent protein kinase 0.0035 0.0566 0.1791
Onchocerca volvulus 0.0017 0.0217 0.5152
Trypanosoma brucei glucose transporter, putative 0.0037 0.0621 0.868
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0008 0.0043 0.009
Echinococcus multilocularis neuropeptide receptor A26 0.0008 0.0043 0.009
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0414 0.0625
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.038 0.1187
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0333 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0008 0.0043 0.009
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0117 0.0329
Trypanosoma cruzi hexose transporter 0.0037 0.0621 0.868
Echinococcus granulosus hypothetical protein 0.0008 0.0043 0.009
Brugia malayi nuclear hormone receptor 0.0012 0.0117 0.0449
Brugia malayi putative neuropeptide receptor 0.0008 0.0043 0.0122
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.038 0.1187
Giardia lamblia Prolyl-tRNA synthetase 0.0036 0.0597 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0036 0.0597 0.2583
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.038 0.1187
Schistosoma mansoni nuclear receptor 0.0012 0.0117 0.0329
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0414 0.0399
Loa Loa (eye worm) hypothetical protein 0.0027 0.0414 0.1769
Echinococcus multilocularis nuclear receptor nhr 48 0.0012 0.0117 0.0329
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0117 0.0329
Schistosoma mansoni hypothetical protein 0.0008 0.0043 0.009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0043 0.009
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0117 0.0329
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0007 0.0016 0.0468
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0117 0.0329
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0117 0.0449
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0043 0.009
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0043 0.009
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0008 0.0043 0.009
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0621 0.274
Brugia malayi hypothetical protein 0.0012 0.0117 0.0449
Schistosoma mansoni sugar transporter 0.0017 0.0217 0.0655
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0043 0.009
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0008 0.0043 0.009
Echinococcus granulosus g-protein coupled receptor 0.0008 0.0043 0.009
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0008 0.0043 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0217 0.0956
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0611 0.1938
Brugia malayi Dopamine receptor protein 2 0.0008 0.0043 0.0122
Brugia malayi nuclear receptor NHR-67 0.0012 0.0117 0.0449
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.038 0.162
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.038 0.1187
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0269 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.038 0.1187
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0217 0.0956
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0597 0.1893

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 54.3 nM Displacement of [3H]-U-69,593 from Opioid receptor kappa 1 in guinea pig cerebellar. ChEMBL. 10956208
Ki (binding) = 54.3 nM Displacement of [3H]-U-69,593 from Opioid receptor kappa 1 in guinea pig cerebellar. ChEMBL. 10956208
Ki (binding) = 2300 nM Displacement of [3H]-diprenorphine from opioid receptor mu 1 on crude membrane fractions obtained from whole rat brain (minus cerebellum) ChEMBL. 10956208
Ki (binding) = 2300 nM Displacement of [3H]-diprenorphine from opioid receptor mu 1 on crude membrane fractions obtained from whole rat brain (minus cerebellum) ChEMBL. 10956208
Ki (binding) > 25000 nM Displacement of [3H]-diprenorphine opioid receptor delta 1 on crude membrane fractions obtained from the whole rat brain (minus cerebellum) ChEMBL. 10956208
Ki (binding) > 25000 nM Displacement of [3H]-diprenorphine opioid receptor delta 1 on crude membrane fractions obtained from the whole rat brain (minus cerebellum) ChEMBL. 10956208
NC (binding) Ratio of affinity towards delta to kappa opioid receptor; NC means not calculated ChEMBL. 10956208
NC (binding) 0 Ratio of affinity towards delta to kappa opioid receptor; NC means not calculated ChEMBL. 10956208
Selectivity ratio (binding) = 42.36 Ratio of affinity towards mu and kappa opioid receptors ChEMBL. 10956208

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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