Detailed information for compound 1697796

Basic information

Technical information
  • TDR Targets ID: 1697796
  • Name: ethyl N-[4-[[2-(2,4-dichlorophenyl)-2-(imidaz ol-1-ylmethyl)-1,3-dioxolan-4-yl]methylsulfan yl]phenyl]carbamate
  • MW: 508.417 | Formula: C23H23Cl2N3O4S
  • H donors: 1 H acceptors: 2 LogP: 4.35 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)Nc1ccc(cc1)SCC1COC(O1)(Cn1cncc1)c1ccc(cc1Cl)Cl
  • InChi: 1S/C23H23Cl2N3O4S/c1-2-30-22(29)27-17-4-6-19(7-5-17)33-13-18-12-31-23(32-18,14-28-10-9-26-15-28)20-8-3-16(24)11-21(20)25/h3-11,15,18H,2,12-14H2,1H3,(H,27,29)
  • InChiKey: OGPIBXIQNMQSPY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[[2-(2,4-dichlorophenyl)-2-(1-imidazolylmethyl)-1,3-dioxolan-4-yl]methylthio]phenyl]carbamic acid ethyl ester
  • N-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methylthio]phenyl]carbamic acid ethyl ester
  • NSC376450
  • Tubulozole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Tubulin beta 2C chain 0.0636 0.7854 0.7854
Echinococcus multilocularis Tubulin alpha 1 chain 0.0492 0.6055 0.6054
Echinococcus granulosus beta tubulin 0.0636 0.7854 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.1156 0.1341
Brugia malayi beta-tubulin, identical 0.0636 0.7854 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0296 0.0232
Trichomonas vaginalis tubulin beta chain, putative 0.0492 0.6055 0.7709
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0707 0.0761
Trichomonas vaginalis tubulin beta chain, putative 0.0492 0.6055 0.7709
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0075 0.0095
Trypanosoma brucei alpha tubulin, putative 0.0197 0.2359 0.2884
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0414 0.0527
Trichomonas vaginalis tubulin epsilon chain, putative 0.0492 0.6055 0.7709
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Loa Loa (eye worm) beta-tubulin 0.0636 0.7854 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Trichomonas vaginalis tubulin epsilon chain, putative 0.0492 0.6055 0.7709
Trichomonas vaginalis tubulin beta chain, putative 0.0636 0.7854 1
Trichomonas vaginalis tubulin, putative 0.0199 0.2383 0.3034
Loa Loa (eye worm) BEN-1 protein 0.0636 0.7854 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.0296 0.3593 0.4491
Echinococcus multilocularis tubulin epsilon chain 0.0395 0.4839 0.4839
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.4859 0.4859
Giardia lamblia Beta tubulin 0.0636 0.7854 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0414 0.0366
Loa Loa (eye worm) hypothetical protein 0.0492 0.6055 0.7674
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0492 0.6055 0.7709
Plasmodium vivax tubulin gamma chain, putative 0.0396 0.4845 0.6104
Echinococcus multilocularis tubulin alpha chain 0.0492 0.6055 0.6054
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0613 0.0639
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.1156 0.1344
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0296 0.0376
Brugia malayi Tubulin alpha chain 0.0166 0.1975 0.2403
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Brugia malayi Tubulin beta-1 chain 0.0636 0.7854 1
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Echinococcus granulosus tubulin delta chain 0.0166 0.1975 0.2515
Echinococcus multilocularis tubulin subunit TubB 0.0492 0.6055 0.6054
Loa Loa (eye worm) tubulin alpha 2 0.0326 0.3977 0.4988
Trypanosoma cruzi epsilon tubulin, putative 0.0395 0.4839 0.6096
Trypanosoma brucei beta tubulin 0.0363 0.4437 0.5575
Echinococcus granulosus tubulin alpha chain 0.0492 0.6055 0.7709
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0166 0.1975 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0132 0.0666
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0414 0.0527
Schistosoma mansoni hypothetical protein 0.0032 0.0296 0.0376
Schistosoma mansoni tubulin subunit epsilon 0.0395 0.4839 0.6161
Leishmania major beta tubulin 0.0636 0.7854 1
Toxoplasma gondii alpha-tubulin I, putative 0.0492 0.6055 0.767
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Trypanosoma brucei beta tubulin 0.0636 0.7854 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Echinococcus multilocularis tubulin subunit beta 0.0636 0.7854 0.7854
Trypanosoma cruzi tubulin delta chain 0.0368 0.4495 0.5651
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0076
Echinococcus granulosus tubulin gamma 1 chain 0.0396 0.4845 0.6169
Brugia malayi Tubulin gamma chain 0.0396 0.4845 0.6112
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0296 0.0229
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Leishmania major beta tubulin 0.0636 0.7854 1
Giardia lamblia Gamma tubulin 0.0396 0.4845 0.6104
Echinococcus multilocularis Tubulin beta 2C chain 0.0636 0.7854 0.7854
Leishmania major beta tubulin 0.0636 0.7854 1
Loa Loa (eye worm) alpha-tubulin 0.0492 0.6055 0.7674
Loa Loa (eye worm) RNA binding protein 0.0065 0.0707 0.0761
Brugia malayi Tubulin alpha chain 0.0492 0.6055 0.7675
Trichomonas vaginalis tubulin, putative 0.0197 0.2359 0.3004
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Schistosoma mansoni tubulin subunit alpha 0.0492 0.6055 0.7709
Echinococcus granulosus beta tubulin 0.0636 0.7854 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0132 0.0131
Echinococcus granulosus GPCR family 2 0.0032 0.0296 0.0376
Trypanosoma brucei alpha tubulin 0.0492 0.6055 0.767
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0707 0.0901
Schistosoma mansoni tubulin subunit alpha 0.0492 0.6055 0.7709
Loa Loa (eye worm) BEN-1 protein 0.0636 0.7854 1
Leishmania major zeta tubulin, putative 0.0503 0.6188 0.7843
Loa Loa (eye worm) tubulin beta chain 0.0166 0.1975 0.24
Loa Loa (eye worm) tubulin beta-1 chain 0.0636 0.7854 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0075 0.0075
Schistosoma mansoni tubulin subunit beta 0.0636 0.7854 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0414 0.0366
Schistosoma mansoni ap endonuclease 0.0019 0.0132 0.0168
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0198 0.2377 0.2908
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0076
Echinococcus multilocularis Tubulin alpha 1 chain 0.0492 0.6055 0.6054
Schistosoma mansoni tubulin subunit beta 0.0636 0.7854 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0296 0.0376
Trypanosoma brucei tubulin delta chain 0.0368 0.4495 0.5651
Giardia lamblia Beta tubulin 0.0636 0.7854 1
Trypanosoma cruzi tubulin gamma chain 0.0396 0.4845 0.6104
Loa Loa (eye worm) hypothetical protein 0.0326 0.3977 0.4988
Schistosoma mansoni cpg binding protein 0.006 0.0654 0.0832
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0326 0.3977 0.5063
Plasmodium vivax delta tubulin, putative 0.0166 0.1975 0.2387
Leishmania major beta tubulin 0.0636 0.7854 1
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0371 0.031
Leishmania major beta tubulin 0.0636 0.7854 1
Leishmania major gamma-tubulin 0.0396 0.4845 0.6104
Loa Loa (eye worm) tubulin alpha 2 0.0326 0.3977 0.4988
Trypanosoma brucei epsilon tubulin 0.0395 0.4839 0.6096
Echinococcus multilocularis Tubulin beta 2C chain 0.0636 0.7854 0.7854
Trichomonas vaginalis tubulin gamma chain, putative 0.0636 0.7854 1
Schistosoma mansoni hypothetical protein 0.0032 0.0296 0.0376
Trichomonas vaginalis tubulin alpha chain, putative 0.0197 0.2359 0.3004
Echinococcus granulosus tubulin subunit beta 0.0636 0.7854 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0636 0.7854 1
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0707 0.0761
Trypanosoma brucei beta tubulin 0.0636 0.7854 1
Echinococcus granulosus tubulin alpha chain 0.0492 0.6055 0.7709
Schistosoma mansoni cpg binding protein 0.0057 0.0613 0.0781
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0707 0.0901
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0707 0.0901
Echinococcus granulosus tubulin beta 1 chain 0.0636 0.7854 1
Treponema pallidum cell division protein FtsZ 0.0166 0.1975 1
Trypanosoma cruzi tubulin delta chain 0.0368 0.4495 0.5651
Leishmania major epsilon tubulin, putative 0.0395 0.4839 0.6096
Plasmodium vivax tubulin beta chain, putative 0.0636 0.7854 1
Echinococcus granulosus tubulin alpha 3 chain 0.0492 0.6055 0.7709
Brugia malayi tubulin alpha-2 chain 0.0492 0.6055 0.7675
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0758 0.0829
Leishmania major beta tubulin 0.0636 0.7854 1
Schistosoma mansoni tubulin subunit gamma 0.0396 0.4845 0.6169
Echinococcus multilocularis GPCR, family 2 0.0032 0.0296 0.0295
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0707 0.0901
Loa Loa (eye worm) tubulin gamma chain 0.0396 0.4845 0.611
Trypanosoma brucei zeta tubulin 0.0503 0.6188 0.7843
Brugia malayi Tubulin beta chain 0.0166 0.1975 0.2403
Trypanosoma brucei beta tubulin 0.0636 0.7854 1
Loa Loa (eye worm) acetyltransferase 0.0141 0.1656 0.1987
Entamoeba histolytica tubulin family protein 0.0636 0.7854 1
Trypanosoma brucei alpha tubulin 0.0492 0.6055 0.767
Echinococcus multilocularis tubulin alpha chain 0.0492 0.6055 0.6054
Leishmania major delta tubulin, putative 0.0368 0.4495 0.5651
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Mycobacterium tuberculosis Cell division protein FtsZ 0.0166 0.1975 1
Trypanosoma cruzi epsilon tubulin, putative 0.0395 0.4839 0.6096
Leishmania major beta tubulin 0.0636 0.7854 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0492 0.6055 0.6054
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.1415 0.1802
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0363 0.4437 0.5575
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0414 0.0527
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0119 0.0119
Loa Loa (eye worm) tubulin alpha 2 0.0129 0.1515 0.1805
Trichomonas vaginalis helicase, putative 0.0013 0.006 0.0076
Echinococcus multilocularis cpg binding protein 0.006 0.0654 0.0654
Leishmania major beta tubulin 0.0636 0.7854 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0371 0.031
Echinococcus granulosus Tubulin alpha 1 chain 0.0492 0.6055 0.7709
Echinococcus multilocularis tubulin delta chain 0.0166 0.1975 0.1975
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0132 0.0167
Trichomonas vaginalis tubulin gamma chain, putative 0.0396 0.4845 0.6169
Trichomonas vaginalis conserved hypothetical protein 0.0166 0.1975 0.2515
Trypanosoma brucei alpha tubulin 0.0492 0.6055 0.767
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Toxoplasma gondii beta tubulin 0.0636 0.7854 1
Trichomonas vaginalis tubulin beta chain, putative 0.0492 0.6055 0.7709
Entamoeba histolytica tubulin alpha chain, putative 0.0492 0.6055 0.767
Schistosoma mansoni tubulin subunit alpha 0.0492 0.6055 0.7709
Echinococcus granulosus Tubulin alpha 1 chain 0.0492 0.6055 0.7709
Entamoeba histolytica tubulin gamma chain 0.0396 0.4845 0.6104
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0076
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0414 0.0366
Echinococcus multilocularis tubulin beta 1 chain 0.0636 0.7854 0.7854
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Echinococcus multilocularis tubulin alpha 3 chain 0.0492 0.6055 0.6054
Trichomonas vaginalis tubulin, putative 0.0636 0.7854 1
Giardia lamblia Alpha-tubulin 0.0492 0.6055 0.767
Toxoplasma gondii beta-1 tubulin, putative 0.0636 0.7854 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0076
Plasmodium falciparum tubulin delta chain, putative 0.0166 0.1975 0.2387
Loa Loa (eye worm) tubulin beta-4 chain 0.0636 0.7854 1
Plasmodium vivax tubulin alpha chain, putative 0.0492 0.6055 0.767
Trichomonas vaginalis tubulin alpha chain, putative 0.0197 0.2359 0.3004
Echinococcus multilocularis tubulin gamma 1 chain 0.0396 0.4845 0.4845
Schistosoma mansoni tubulin subunit delta 0.0166 0.1975 0.2515
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0707 0.0764
Brugia malayi Tubulin alpha-2 chain 0.0492 0.6055 0.7675
Onchocerca volvulus 0.0197 0.2359 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0758 0.0826
Plasmodium falciparum tubulin epsilon chain, putative 0.0395 0.4839 0.6096
Schistosoma mansoni alpha tubulin 0.0492 0.6055 0.7709
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Toxoplasma gondii tubulin, putative 0.0032 0.0299 0.0217
Trypanosoma brucei beta tubulin 0.0636 0.7854 1
Schistosoma mansoni tubulin subunit beta 0.0636 0.7854 1
Leishmania major beta tubulin 0.0636 0.7854 1
Echinococcus granulosus tubulin alpha chain 0.0492 0.6055 0.7709
Leishmania major beta tubulin 0.0636 0.7854 1
Giardia lamblia Alpha-tubulin 0.0492 0.6055 0.767
Trichomonas vaginalis tubulin epsilon chain, putative 0.0636 0.7854 1
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Trypanosoma brucei tubulin gamma chain 0.0396 0.4845 0.6104
Schistosoma mansoni cpg binding protein 0.006 0.0654 0.0832
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0132 0.0017
Echinococcus granulosus Tubulin beta 2C chain 0.0636 0.7854 1
Plasmodium falciparum alpha tubulin 1 0.0492 0.6055 0.767
Loa Loa (eye worm) tubulin alpha chain 0.0492 0.6055 0.7674
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Trichomonas vaginalis tubulin alpha chain, putative 0.0197 0.2359 0.3004
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0371 0.031
Echinococcus granulosus peroxisome assembly protein 26 0.0492 0.6055 0.7709
Brugia malayi CXXC zinc finger family protein 0.0057 0.0613 0.0642
Plasmodium falciparum tubulin gamma chain 0.0396 0.4845 0.6104
Schistosoma mansoni hypothetical protein 0.0032 0.0296 0.0376
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0296 0.0295
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.1156 0.1344
Leishmania major beta tubulin 0.0636 0.7854 1
Echinococcus multilocularis tubulin alpha chain 0.0492 0.6055 0.6054
Schistosoma mansoni hypothetical protein 0.0397 0.4859 0.6187
Schistosoma mansoni tubulin subunit beta 0.0636 0.7854 1
Plasmodium vivax tubulin alpha chain, putative 0.0492 0.6055 0.767
Trypanosoma cruzi zeta tubulin, putative 0.0503 0.6188 0.7843
Echinococcus multilocularis hypothetical protein 0.0492 0.6055 0.6054
Loa Loa (eye worm) tubulin alpha-2 chain 0.0492 0.6055 0.7674
Echinococcus granulosus tubulin alpha 1C chain 0.0492 0.6055 0.7709
Echinococcus granulosus Tubulin beta 2C chain 0.0636 0.7854 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0132 0.0666
Trichomonas vaginalis tubulin gamma chain, putative 0.0166 0.1975 0.2515
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Echinococcus multilocularis tubulin alpha 1C chain 0.0492 0.6055 0.6054
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.1656 0.199
Echinococcus granulosus tubulin alpha 1C chain 0.0492 0.6055 0.7709
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.1606 0.2045
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0636 0.7854 0.7854
Echinococcus multilocularis tubulin alpha 1C chain 0.0492 0.6055 0.6054
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0296 0.0295
Leishmania major beta tubulin 0.0636 0.7854 1
Echinococcus multilocularis beta tubulin 0.0636 0.7854 0.7854
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0368 0.4495 0.5651
Brugia malayi alpha-tubulin 0.0492 0.6055 0.7675
Echinococcus granulosus Tubulin beta 2C chain 0.0636 0.7854 1
Mycobacterium leprae cell division protein FtsZ 0.0166 0.1975 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0119 0.0151
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0132 0.0167
Toxoplasma gondii alpha tubulin TUBA1 0.0492 0.6055 0.767
Echinococcus granulosus Tubulin alpha 1 chain 0.0492 0.6055 0.7709
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Plasmodium falciparum tubulin beta chain 0.0636 0.7854 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0395 0.4839 0.6161
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.006 0.0076
Echinococcus granulosus tubulin subunit TubB 0.0492 0.6055 0.7709
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.1656 0.1655
Giardia lamblia Beta tubulin 0.0636 0.7854 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.1156 0.1341
Schistosoma mansoni alpha tubulin 0.0492 0.6055 0.7709
Echinococcus granulosus alpha tubulin 0.0492 0.6055 0.7709
Schistosoma mansoni alpha tubulin 0.0492 0.6055 0.7709
Entamoeba histolytica tubulin family protein 0.0636 0.7854 1
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Loa Loa (eye worm) alpha-tubulin 0.0492 0.6055 0.7674
Trichomonas vaginalis tubulin alpha chain, putative 0.0363 0.4437 0.5649
Schistosoma mansoni tubulin subunit beta 0.0636 0.7854 1
Trichomonas vaginalis conserved hypothetical protein 0.0166 0.1975 0.2515
Leishmania major beta tubulin 0.0636 0.7854 1
Echinococcus granulosus tubulin alpha chain 0.0492 0.6055 0.7709
Loa Loa (eye worm) tubulin beta chain 0.0636 0.7854 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0296 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0132 0.0167
Echinococcus multilocularis Tubulin alpha 1 chain 0.0492 0.6055 0.6054
Trypanosoma cruzi zeta tubulin, putative 0.0503 0.6188 0.7843
Trypanosoma brucei alpha tubulin 0.0492 0.6055 0.767
Trypanosoma brucei zeta tubulin, putative 0.0503 0.6188 0.7843
Brugia malayi Tubulin beta chain 0.0197 0.2359 0.2899
Echinococcus granulosus tar DNA binding protein 0.0065 0.0707 0.09
Echinococcus multilocularis beta tubulin 0.0636 0.7854 0.7854
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0076
Schistosoma mansoni hypothetical protein 0.0032 0.0296 0.0376
Echinococcus granulosus tubulin epsilon chain 0.0395 0.4839 0.6161
Echinococcus granulosus Tubulin beta 2C chain 0.0636 0.7854 1
Echinococcus granulosus tubulin alpha 0.0363 0.4437 0.5649
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0132 0.002
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0707 0.0901
Trichomonas vaginalis tubulin alpha chain, putative 0.0636 0.7854 1
Brugia malayi Tubulin alpha-2 chain 0.0492 0.6055 0.7675
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0075 0.0096
Schistosoma mansoni tubulin subunit beta 0.0636 0.7854 1
Leishmania major beta tubulin 0.0636 0.7854 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.1656 0.2108
Trichomonas vaginalis tubulin epsilon chain, putative 0.0166 0.1975 0.2515
Echinococcus granulosus Tubulin beta 2C chain 0.0636 0.7854 1
Echinococcus granulosus dnaJ subfamily B 0.0397 0.4859 0.6187
Schistosoma mansoni tubulin subunit beta 0.0166 0.1975 0.2515
Echinococcus multilocularis tubulin alpha chain 0.0492 0.6055 0.6054
Echinococcus multilocularis tubulin alpha chain 0.0492 0.6055 0.6054
Trypanosoma cruzi alpha tubulin, putative 0.0492 0.6055 0.767
Leishmania major beta tubulin 0.0636 0.7854 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0636 0.7854 1
Schistosoma mansoni ap endonuclease 0.0019 0.0132 0.0168
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0075 0.0095
Brugia malayi tubulin alpha chain - mouse 0.0492 0.6055 0.7675
Trypanosoma brucei epsilon tubulin 0.0363 0.4437 0.5575
Trichomonas vaginalis tubulin beta chain, putative 0.0492 0.6055 0.7709
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0075 0.0075
Mycobacterium ulcerans cell division protein FtsZ 0.0166 0.1975 1
Giardia lamblia Delta tubulin 0.0166 0.1975 0.2387
Echinococcus granulosus tubulin alpha chain 0.0492 0.6055 0.7709
Trypanosoma cruzi beta tubulin, putative 0.0636 0.7854 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.3593 0.4491
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0707 0.0707
Leishmania major beta tubulin 0.0636 0.7854 1
Trypanosoma brucei epsilon tubulin 0.0395 0.4839 0.6096
Brugia malayi RNA binding protein 0.0065 0.0707 0.0764
Entamoeba histolytica tubulin alpha-1 chain 0.0492 0.6055 0.767
Brugia malayi TAR-binding protein 0.0065 0.0707 0.0764
Trichomonas vaginalis tubulin beta chain, putative 0.0492 0.6055 0.7709
Schistosoma mansoni hypothetical protein 0.0069 0.0758 0.0965
Leishmania major beta tubulin 0.0636 0.7854 1
Echinococcus multilocularis peroxisome assembly protein 26 0.0492 0.6055 0.6054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0076
Toxoplasma gondii beta-tubulin, putative 0.0636 0.7854 1
Echinococcus multilocularis tubulin alpha 0.0363 0.4437 0.4437
Echinococcus granulosus cpg binding protein 0.006 0.0654 0.0832
Giardia lamblia Epsilon tubulin 0.0198 0.2377 0.2908
Leishmania major beta tubulin 0.0636 0.7854 1
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0166 0.1975 0.2515
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0132 0.0666
Trichomonas vaginalis tubulin beta chain, putative 0.0492 0.6055 0.7709
Loa Loa (eye worm) tubulin alpha chain 0.0492 0.6055 0.7674
Brugia malayi Cell division protein ftsZ 0.0166 0.1975 0.2403
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0296 0.0232
Plasmodium vivax tubulin epsilon chain, putative 0.0395 0.4839 0.6096
Trichomonas vaginalis tubulin, putative 0.0197 0.2359 0.3004
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0326 0.3977 0.4988
Loa Loa (eye worm) tubulin beta-2A chain 0.0636 0.7854 1
Schistosoma mansoni tubulin subunit alpha 0.0166 0.1975 0.2515
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.006 0.0076
Echinococcus multilocularis Tubulin beta 2C chain 0.0636 0.7854 0.7854
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.1296 0.1508
Trichomonas vaginalis tubulin beta chain, putative 0.0197 0.2359 0.3004
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0296 0.3593 0.4575
Echinococcus multilocularis Tubulin beta 2C chain 0.0636 0.7854 0.7854
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0197 0.2359 0.3004
Plasmodium falciparum alpha tubulin 2 0.0492 0.6055 0.767
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0132 0.0666
Echinococcus granulosus tubulin alpha 3 chain 0.0492 0.6055 0.7709

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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