Detailed information for compound 1697796

Basic information

Technical information
  • TDR Targets ID: 1697796
  • Name: ethyl N-[4-[[2-(2,4-dichlorophenyl)-2-(imidaz ol-1-ylmethyl)-1,3-dioxolan-4-yl]methylsulfan yl]phenyl]carbamate
  • MW: 508.417 | Formula: C23H23Cl2N3O4S
  • H donors: 1 H acceptors: 2 LogP: 4.35 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)Nc1ccc(cc1)SCC1COC(O1)(Cn1cncc1)c1ccc(cc1Cl)Cl
  • InChi: 1S/C23H23Cl2N3O4S/c1-2-30-22(29)27-17-4-6-19(7-5-17)33-13-18-12-31-23(32-18,14-28-10-9-26-15-28)20-8-3-16(24)11-21(20)25/h3-11,15,18H,2,12-14H2,1H3,(H,27,29)
  • InChiKey: OGPIBXIQNMQSPY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[[2-(2,4-dichlorophenyl)-2-(1-imidazolylmethyl)-1,3-dioxolan-4-yl]methylthio]phenyl]carbamic acid ethyl ester
  • N-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methylthio]phenyl]carbamic acid ethyl ester
  • NSC376450
  • Tubulozole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi RNA binding protein 0.0065 0.0707 0.0764
Trypanosoma cruzi zeta tubulin, putative 0.0503 0.6188 0.7843
Echinococcus granulosus tubulin alpha chain 0.0492 0.6055 0.7709
Echinococcus multilocularis hypothetical protein 0.0492 0.6055 0.6054
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.006 0.0076
Echinococcus multilocularis Tubulin beta 2C chain 0.0636 0.7854 0.7854
Trypanosoma cruzi epsilon tubulin, putative 0.0395 0.4839 0.6096
Trypanosoma brucei zeta tubulin 0.0503 0.6188 0.7843
Trypanosoma brucei tubulin delta chain 0.0368 0.4495 0.5651
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0371 0.031
Loa Loa (eye worm) RNA binding protein 0.0065 0.0707 0.0761
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.1606 0.2045
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0075 0.0095
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0296 0.0295
Echinococcus multilocularis tubulin beta 1 chain 0.0636 0.7854 0.7854
Loa Loa (eye worm) alpha-tubulin 0.0492 0.6055 0.7674
Giardia lamblia Beta tubulin 0.0636 0.7854 1
Echinococcus granulosus Tubulin beta 2C chain 0.0636 0.7854 1
Leishmania major beta tubulin 0.0636 0.7854 1
Leishmania major beta tubulin 0.0636 0.7854 1
Toxoplasma gondii beta tubulin 0.0636 0.7854 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0492 0.6055 0.7709
Trichomonas vaginalis conserved hypothetical protein 0.0166 0.1975 0.2515
Echinococcus granulosus Tubulin alpha 1 chain 0.0492 0.6055 0.7709
Schistosoma mansoni hypothetical protein 0.0032 0.0296 0.0376
Trichomonas vaginalis helicase, putative 0.0013 0.006 0.0076
Trichomonas vaginalis tubulin gamma chain, putative 0.0166 0.1975 0.2515
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.1156 0.1341
Schistosoma mansoni tubulin subunit beta 0.0166 0.1975 0.2515
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0296 0.0376
Echinococcus multilocularis tubulin gamma 1 chain 0.0396 0.4845 0.4845
Treponema pallidum cell division protein FtsZ 0.0166 0.1975 1
Schistosoma mansoni ap endonuclease 0.0019 0.0132 0.0168
Echinococcus multilocularis GPCR, family 2 0.0032 0.0296 0.0295
Leishmania major gamma-tubulin 0.0396 0.4845 0.6104
Trypanosoma cruzi zeta tubulin, putative 0.0503 0.6188 0.7843
Brugia malayi Tubulin alpha-2 chain 0.0492 0.6055 0.7675
Leishmania major beta tubulin 0.0636 0.7854 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0636 0.7854 1
Schistosoma mansoni hypothetical protein 0.0032 0.0296 0.0376
Trichomonas vaginalis tubulin epsilon chain, putative 0.0166 0.1975 0.2515
Schistosoma mansoni hypothetical protein 0.0032 0.0296 0.0376
Echinococcus multilocularis peroxisome assembly protein 26 0.0492 0.6055 0.6054
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0076
Leishmania major beta tubulin 0.0636 0.7854 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0132 0.002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.1156 0.1344
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0296 0.0376
Mycobacterium leprae cell division protein FtsZ 0.0166 0.1975 1
Trypanosoma brucei alpha tubulin 0.0492 0.6055 0.767
Leishmania major beta tubulin 0.0636 0.7854 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0707 0.0901
Loa Loa (eye worm) tubulin alpha 2 0.0326 0.3977 0.4988
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0132 0.0167
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0363 0.4437 0.5575
Echinococcus multilocularis tubulin alpha chain 0.0492 0.6055 0.6054
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0166 0.1975 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0296 0.0232
Echinococcus multilocularis beta tubulin 0.0636 0.7854 0.7854
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Echinococcus granulosus beta tubulin 0.0636 0.7854 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0414 0.0366
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0414 0.0527
Trypanosoma cruzi tubulin delta chain 0.0368 0.4495 0.5651
Mycobacterium ulcerans cell division protein FtsZ 0.0166 0.1975 1
Loa Loa (eye worm) tubulin alpha chain 0.0492 0.6055 0.7674
Echinococcus multilocularis Tubulin alpha 1 chain 0.0492 0.6055 0.6054
Plasmodium vivax tubulin epsilon chain, putative 0.0395 0.4839 0.6096
Echinococcus multilocularis tubulin alpha 1C chain 0.0492 0.6055 0.6054
Loa Loa (eye worm) tubulin beta chain 0.0636 0.7854 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0132 0.0666
Trichomonas vaginalis tubulin beta chain, putative 0.0492 0.6055 0.7709
Loa Loa (eye worm) tubulin alpha 2 0.0326 0.3977 0.4988
Trichomonas vaginalis tubulin epsilon chain, putative 0.0636 0.7854 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0296 0.0232
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0166 0.1975 0.2515
Trichomonas vaginalis tubulin gamma chain, putative 0.0396 0.4845 0.6169
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0197 0.2359 0.3004
Leishmania major beta tubulin 0.0636 0.7854 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0119 0.0151
Brugia malayi beta-tubulin, identical 0.0636 0.7854 1
Plasmodium falciparum alpha tubulin 2 0.0492 0.6055 0.767
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0119 0.0119
Echinococcus granulosus tubulin gamma 1 chain 0.0396 0.4845 0.6169
Echinococcus granulosus tubulin delta chain 0.0166 0.1975 0.2515
Schistosoma mansoni tubulin subunit alpha 0.0492 0.6055 0.7709
Trypanosoma cruzi tubulin delta chain 0.0368 0.4495 0.5651
Leishmania major beta tubulin 0.0636 0.7854 1
Loa Loa (eye worm) acetyltransferase 0.0141 0.1656 0.1987
Echinococcus granulosus cpg binding protein 0.006 0.0654 0.0832
Loa Loa (eye worm) alpha-tubulin 0.0492 0.6055 0.7674
Echinococcus multilocularis Tubulin alpha 1 chain 0.0492 0.6055 0.6054
Leishmania major epsilon tubulin, putative 0.0395 0.4839 0.6096
Leishmania major beta tubulin 0.0636 0.7854 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0132 0.0167
Schistosoma mansoni tubulin subunit beta 0.0636 0.7854 1
Giardia lamblia Gamma tubulin 0.0396 0.4845 0.6104
Giardia lamblia Beta tubulin 0.0636 0.7854 1
Leishmania major beta tubulin 0.0636 0.7854 1
Trypanosoma brucei zeta tubulin, putative 0.0503 0.6188 0.7843
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0076
Loa Loa (eye worm) BEN-1 protein 0.0636 0.7854 1
Schistosoma mansoni tubulin subunit epsilon 0.0395 0.4839 0.6161
Mycobacterium tuberculosis Cell division protein FtsZ 0.0166 0.1975 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0636 0.7854 1
Schistosoma mansoni cpg binding protein 0.0057 0.0613 0.0781
Echinococcus granulosus GPCR family 2 0.0032 0.0296 0.0376
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0414 0.0527
Echinococcus granulosus dnaJ subfamily B 0.0397 0.4859 0.6187
Plasmodium falciparum alpha tubulin 1 0.0492 0.6055 0.767
Echinococcus multilocularis tubulin delta chain 0.0166 0.1975 0.1975
Leishmania major beta tubulin 0.0636 0.7854 1
Schistosoma mansoni cpg binding protein 0.006 0.0654 0.0832
Trichomonas vaginalis tubulin gamma chain, putative 0.0395 0.4839 0.6161
Loa Loa (eye worm) hypothetical protein 0.0069 0.0758 0.0826
Brugia malayi Tubulin alpha-2 chain 0.0492 0.6055 0.7675
Trypanosoma brucei beta tubulin 0.0636 0.7854 1
Giardia lamblia Alpha-tubulin 0.0492 0.6055 0.767
Trypanosoma brucei tubulin gamma chain 0.0396 0.4845 0.6104
Toxoplasma gondii alpha-tubulin I, putative 0.0492 0.6055 0.767
Trichomonas vaginalis tubulin, putative 0.0197 0.2359 0.3004
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Brugia malayi TAR-binding protein 0.0065 0.0707 0.0764
Leishmania major beta tubulin 0.0636 0.7854 1
Schistosoma mansoni alpha tubulin 0.0492 0.6055 0.7709
Echinococcus granulosus Tubulin beta 2C chain 0.0636 0.7854 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0414 0.0527
Schistosoma mansoni alpha tubulin 0.0492 0.6055 0.7709
Echinococcus multilocularis Tubulin beta 2C chain 0.0636 0.7854 0.7854
Echinococcus multilocularis tubulin alpha chain 0.0492 0.6055 0.6054
Trichomonas vaginalis tubulin epsilon chain, putative 0.0636 0.7854 1
Echinococcus granulosus tar DNA binding protein 0.0065 0.0707 0.09
Echinococcus granulosus tubulin alpha 1C chain 0.0492 0.6055 0.7709
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0707 0.0901
Trichomonas vaginalis tubulin alpha chain, putative 0.0197 0.2359 0.3004
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0132 0.0167
Brugia malayi Tubulin alpha chain 0.0166 0.1975 0.2403
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0371 0.031
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0707 0.0901
Loa Loa (eye worm) tubulin alpha 2 0.0129 0.1515 0.1805
Echinococcus granulosus tubulin alpha 3 chain 0.0492 0.6055 0.7709
Schistosoma mansoni tubulin subunit beta 0.0636 0.7854 1
Schistosoma mansoni hypothetical protein 0.0069 0.0758 0.0965
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.1156 0.1344
Echinococcus multilocularis tubulin alpha 3 chain 0.0492 0.6055 0.6054
Trichomonas vaginalis tubulin, putative 0.0199 0.2383 0.3034
Echinococcus granulosus tubulin beta 1 chain 0.0636 0.7854 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0132 0.0666
Trichomonas vaginalis tubulin beta chain, putative 0.0492 0.6055 0.7709
Loa Loa (eye worm) hypothetical protein 0.0326 0.3977 0.4988
Echinococcus granulosus beta tubulin 0.0636 0.7854 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0371 0.031
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Echinococcus granulosus tubulin subunit TubB 0.0492 0.6055 0.7709
Trichomonas vaginalis tubulin alpha chain, putative 0.0636 0.7854 1
Trypanosoma cruzi beta tubulin, putative 0.0636 0.7854 1
Brugia malayi Cell division protein ftsZ 0.0166 0.1975 0.2403
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.1656 0.2108
Schistosoma mansoni hypothetical protein 0.0032 0.0296 0.0376
Plasmodium vivax tubulin gamma chain, putative 0.0396 0.4845 0.6104
Leishmania major beta tubulin 0.0636 0.7854 1
Schistosoma mansoni cpg binding protein 0.006 0.0654 0.0832
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Schistosoma mansoni tubulin subunit gamma 0.0396 0.4845 0.6169
Loa Loa (eye worm) tubulin alpha-2 chain 0.0492 0.6055 0.7674
Brugia malayi CXXC zinc finger family protein 0.0057 0.0613 0.0642
Trichomonas vaginalis tubulin beta chain, putative 0.0492 0.6055 0.7709
Trypanosoma brucei beta tubulin 0.0636 0.7854 1
Giardia lamblia Epsilon tubulin 0.0198 0.2377 0.2908
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0075 0.0075
Entamoeba histolytica tubulin family protein 0.0636 0.7854 1
Trichomonas vaginalis conserved hypothetical protein 0.0166 0.1975 0.2515
Schistosoma mansoni tubulin subunit beta 0.0636 0.7854 1
Echinococcus granulosus peroxisome assembly protein 26 0.0492 0.6055 0.7709
Echinococcus granulosus tubulin alpha chain 0.0492 0.6055 0.7709
Trypanosoma brucei alpha tubulin 0.0492 0.6055 0.767
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0414 0.0366
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0132 0.0131
Schistosoma mansoni alpha tubulin 0.0492 0.6055 0.7709
Plasmodium vivax tubulin alpha chain, putative 0.0492 0.6055 0.767
Leishmania major beta tubulin 0.0636 0.7854 1
Plasmodium vivax delta tubulin, putative 0.0166 0.1975 0.2387
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0076
Trichomonas vaginalis tubulin beta chain, putative 0.0197 0.2359 0.3004
Loa Loa (eye worm) hypothetical protein 0.0101 0.1156 0.1341
Trichomonas vaginalis tubulin alpha chain, putative 0.0197 0.2359 0.3004
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0132 0.0017
Schistosoma mansoni tubulin subunit beta 0.0636 0.7854 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0636 0.7854 0.7854
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Plasmodium falciparum tubulin beta chain 0.0636 0.7854 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.0296 0.3593 0.4491
Echinococcus multilocularis tubulin epsilon chain 0.0395 0.4839 0.4839
Echinococcus granulosus tubulin alpha 3 chain 0.0492 0.6055 0.7709
Schistosoma mansoni tubulin subunit alpha 0.0492 0.6055 0.7709
Brugia malayi Tubulin alpha chain 0.0492 0.6055 0.7675
Trypanosoma brucei epsilon tubulin 0.0395 0.4839 0.6096
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Brugia malayi Tubulin beta chain 0.0166 0.1975 0.2403
Toxoplasma gondii tubulin, putative 0.0032 0.0299 0.0217
Schistosoma mansoni tubulin subunit alpha 0.0166 0.1975 0.2515
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0075 0.0075
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0076
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0707 0.0764
Echinococcus granulosus tubulin subunit beta 0.0636 0.7854 1
Trypanosoma cruzi tubulin gamma chain 0.0396 0.4845 0.6104
Echinococcus multilocularis tubulin subunit beta 0.0636 0.7854 0.7854
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0326 0.3977 0.5063
Plasmodium falciparum tubulin gamma chain 0.0396 0.4845 0.6104
Trypanosoma brucei alpha tubulin 0.0492 0.6055 0.767
Entamoeba histolytica tubulin alpha-1 chain 0.0492 0.6055 0.767
Entamoeba histolytica tubulin family protein 0.0636 0.7854 1
Plasmodium vivax tubulin alpha chain, putative 0.0492 0.6055 0.767
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.1656 0.199
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0414 0.0366
Trypanosoma brucei beta tubulin 0.0363 0.4437 0.5575
Plasmodium falciparum tubulin epsilon chain, putative 0.0395 0.4839 0.6096
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0707 0.0901
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0132 0.0666
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Plasmodium falciparum tubulin delta chain, putative 0.0166 0.1975 0.2387
Echinococcus multilocularis tubulin alpha 1C chain 0.0492 0.6055 0.6054
Plasmodium vivax tubulin beta chain, putative 0.0636 0.7854 1
Echinococcus granulosus tubulin alpha chain 0.0492 0.6055 0.7709
Echinococcus granulosus tubulin alpha 0.0363 0.4437 0.5649
Echinococcus granulosus alpha tubulin 0.0492 0.6055 0.7709
Trichomonas vaginalis tubulin beta chain, putative 0.0492 0.6055 0.7709
Loa Loa (eye worm) tubulin gamma chain 0.0396 0.4845 0.611
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0296 0.0229
Giardia lamblia Beta tubulin 0.0636 0.7854 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Trichomonas vaginalis tubulin epsilon chain, putative 0.0492 0.6055 0.7709
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0076
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0707 0.0761
Loa Loa (eye worm) beta-tubulin 0.0636 0.7854 1
Leishmania major beta tubulin 0.0636 0.7854 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0492 0.6055 0.6054
Trypanosoma brucei beta tubulin 0.0636 0.7854 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.006 0.0076
Echinococcus multilocularis tubulin alpha 0.0363 0.4437 0.4437
Echinococcus multilocularis Tubulin beta 2C chain 0.0636 0.7854 0.7854
Loa Loa (eye worm) tubulin beta-1 chain 0.0636 0.7854 1
Toxoplasma gondii alpha tubulin TUBA1 0.0492 0.6055 0.767
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0326 0.3977 0.4988
Trypanosoma brucei alpha tubulin, putative 0.0197 0.2359 0.2884
Loa Loa (eye worm) hypothetical protein 0.0296 0.3593 0.4491
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0296 0.3593 0.4575
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0198 0.2377 0.2908
Brugia malayi tubulin alpha-2 chain 0.0492 0.6055 0.7675
Loa Loa (eye worm) tubulin beta chain 0.0166 0.1975 0.24
Entamoeba histolytica tubulin alpha chain, putative 0.0492 0.6055 0.767
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0492 0.6055 0.7709
Schistosoma mansoni tubulin subunit alpha 0.0492 0.6055 0.7709
Toxoplasma gondii beta-tubulin, putative 0.0636 0.7854 1
Brugia malayi Tubulin gamma chain 0.0396 0.4845 0.6112
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0707 0.0707
Echinococcus multilocularis Tubulin beta 2C chain 0.0636 0.7854 0.7854
Trichomonas vaginalis tubulin, putative 0.0636 0.7854 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0132 0.0666
Echinococcus multilocularis tubulin alpha chain 0.0492 0.6055 0.6054
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0296 0.0295
Echinococcus multilocularis tubulin subunit TubB 0.0492 0.6055 0.6054
Leishmania major beta tubulin 0.0636 0.7854 1
Echinococcus multilocularis beta tubulin 0.0636 0.7854 0.7854
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Giardia lamblia Delta tubulin 0.0166 0.1975 0.2387
Echinococcus granulosus tubulin epsilon chain 0.0395 0.4839 0.6161
Trypanosoma brucei epsilon tubulin 0.0395 0.4839 0.6096
Echinococcus granulosus Tubulin beta 2C chain 0.0636 0.7854 1
Echinococcus multilocularis cpg binding protein 0.006 0.0654 0.0654
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Leishmania major beta tubulin 0.0636 0.7854 1
Trypanosoma brucei epsilon tubulin 0.0363 0.4437 0.5575
Echinococcus multilocularis Tubulin alpha 1 chain 0.0492 0.6055 0.6054
Leishmania major delta tubulin, putative 0.0368 0.4495 0.5651
Schistosoma mansoni tubulin subunit beta 0.0636 0.7854 1
Trichomonas vaginalis tubulin beta chain, putative 0.0636 0.7854 1
Echinococcus multilocularis tubulin alpha chain 0.0492 0.6055 0.6054
Leishmania major beta tubulin 0.0636 0.7854 1
Schistosoma mansoni ap endonuclease 0.0019 0.0132 0.0168
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0076
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Toxoplasma gondii beta-1 tubulin, putative 0.0636 0.7854 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0075 0.0095
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0636 0.7854 0.7854
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0075 0.0096
Loa Loa (eye worm) hypothetical protein 0.0492 0.6055 0.7674
Trypanosoma brucei alpha tubulin 0.0492 0.6055 0.767
Loa Loa (eye worm) BEN-1 protein 0.0636 0.7854 1
Echinococcus granulosus Tubulin beta 2C chain 0.0636 0.7854 1
Giardia lamblia Alpha-tubulin 0.0492 0.6055 0.767
Trichomonas vaginalis tubulin beta chain, putative 0.0492 0.6055 0.7709
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0707 0.0761
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.1656 0.1655
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0707 0.0901
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Loa Loa (eye worm) hypothetical protein 0.0032 0.0296 0.0229
Brugia malayi tubulin alpha chain - mouse 0.0492 0.6055 0.7675
Trichomonas vaginalis tubulin alpha chain, putative 0.0363 0.4437 0.5649
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0613 0.0639
Echinococcus granulosus tubulin alpha 1C chain 0.0492 0.6055 0.7709
Brugia malayi Tubulin beta chain 0.0197 0.2359 0.2899
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Trichomonas vaginalis tubulin alpha chain, putative 0.0197 0.2359 0.3004
Echinococcus granulosus tubulin beta 4A class IVa 0.0636 0.7854 1
Schistosoma mansoni hypothetical protein 0.0397 0.4859 0.6187
Schistosoma mansoni tubulin subunit delta 0.0166 0.1975 0.2515
Trypanosoma cruzi epsilon tubulin, putative 0.0395 0.4839 0.6096
Onchocerca volvulus 0.0197 0.2359 1
Trichomonas vaginalis tubulin, putative 0.0197 0.2359 0.3004
Echinococcus granulosus tubulin alpha chain 0.0492 0.6055 0.7709
Echinococcus granulosus Tubulin alpha 1 chain 0.0492 0.6055 0.7709
Trichomonas vaginalis tubulin beta chain, putative 0.0492 0.6055 0.7709
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0368 0.4495 0.5651
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0758 0.0829
Brugia malayi alpha-tubulin 0.0492 0.6055 0.7675
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.4859 0.4859
Loa Loa (eye worm) tubulin alpha chain 0.0492 0.6055 0.7674
Brugia malayi Tubulin beta-1 chain 0.0636 0.7854 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0492 0.6055 0.7709
Leishmania major zeta tubulin, putative 0.0503 0.6188 0.7843
Echinococcus multilocularis tubulin alpha chain 0.0492 0.6055 0.6054
Loa Loa (eye worm) tubulin beta-4 chain 0.0636 0.7854 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.1296 0.1508
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.1415 0.1802
Echinococcus granulosus Tubulin beta 2C chain 0.0636 0.7854 1
Entamoeba histolytica tubulin gamma chain 0.0396 0.4845 0.6104
Leishmania major beta tubulin 0.0636 0.7854 1
Echinococcus granulosus tubulin alpha chain 0.0492 0.6055 0.7709
Schistosoma mansoni tubulin subunit beta 0.0636 0.7854 1
Trypanosoma cruzi alpha tubulin, putative 0.0492 0.6055 0.767
Trypanosoma brucei beta tubulin 0.0636 0.7854 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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