Detailed information for compound 170498

Basic information

Technical information
  • TDR Targets ID: 170498
  • Name: (Z)-3-(4-methoxyphenyl)-2-(3,4,5-trimethoxyph enyl)prop-2-enenitrile
  • MW: 325.358 | Formula: C19H19NO4
  • H donors: 0 H acceptors: 1 LogP: 3.59 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)/C=C(/c1cc(OC)c(c(c1)OC)OC)\C#N
  • InChi: 1S/C19H19NO4/c1-21-16-7-5-13(6-8-16)9-15(12-20)14-10-17(22-2)19(24-4)18(11-14)23-3/h5-11H,1-4H3/b15-9+
  • InChiKey: IHKBGXGPWWAEPU-OQLLNIDSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (Z)-3-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-2-propenenitrile
  • (Z)-3-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-tubulin 0.029 0.2188 0.2188
Plasmodium falciparum tubulin beta chain 0.029 0.2188 0.9798
Echinococcus granulosus cathepsin l cysteine peptidase 0.0294 0.2233 0.2233
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0232 0.1611 0.5109
Leishmania major beta tubulin 0.029 0.2188 0.6939
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1073 1 1
Echinococcus multilocularis tubulin alpha 0.0162 0.0916 0.0916
Trichomonas vaginalis tubulin epsilon chain, putative 0.029 0.2188 0.6939
Brugia malayi Papain family cysteine protease containing protein 0.0167 0.0958 0.0958
Echinococcus multilocularis tubulin subunit TubB 0.0232 0.1611 0.1611
Loa Loa (eye worm) cysteine protease 0.0294 0.2233 0.2233
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.2233 0.7081
Brugia malayi Cathepsin L-like precursor 0.0087 0.0166 0.0166
Schistosoma mansoni tubulin subunit alpha 0.0232 0.1611 0.1611
Schistosoma mansoni tubulin subunit beta 0.029 0.2188 0.2188
Schistosoma mansoni tubulin subunit alpha 0.0232 0.1611 0.1611
Echinococcus granulosus cathepsin L cysteine proteinase 0.0294 0.2233 0.2233
Brugia malayi Tubulin gamma chain 0.0162 0.0916 0.0916
Brugia malayi tubulin alpha chain - mouse 0.0232 0.1611 0.1611
Echinococcus multilocularis Tubulin beta 2C chain 0.029 0.2188 0.2188
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0162 0.0908 0.2879
Entamoeba histolytica tubulin alpha-1 chain 0.0232 0.1611 0.7099
Trichomonas vaginalis tubulin alpha chain, putative 0.0092 0.0213 0.0676
Giardia lamblia Alpha-tubulin 0.0232 0.1611 0.5109
Treponema pallidum cell division protein FtsZ 0.007 0 0.5
Trichomonas vaginalis tubulin epsilon chain, putative 0.029 0.2188 0.6939
Echinococcus granulosus cathepsin b 0.1073 1 1
Onchocerca volvulus Cathepsin F homolog 0.0294 0.2233 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0079 0.0089 0.0281
Schistosoma mansoni tubulin subunit beta 0.029 0.2188 0.2188
Loa Loa (eye worm) hypothetical protein 0.1073 1 1
Entamoeba histolytica cysteine proteinase 2 0.0167 0.0958 0.4054
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Trypanosoma brucei epsilon tubulin 0.0162 0.0916 0.2906
Leishmania major beta tubulin 0.029 0.2188 0.6939
Brugia malayi Cathepsin L-like cysteine proteinase 0.0207 0.1364 0.1364
Toxoplasma gondii cathepsin CPL 0.0294 0.2233 0.7081
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Giardia lamblia Cathepsin L precursor 0.0079 0.0089 0.0281
Onchocerca volvulus Cathepsin L homolog 0.0294 0.2233 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Trichomonas vaginalis tubulin beta chain, putative 0.0092 0.0213 0.0676
Echinococcus multilocularis Tubulin beta 2C chain 0.029 0.2188 0.2188
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0079 0.0089 0.0397
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.0958 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0294 0.2233 0.7081
Mycobacterium tuberculosis Cell division protein FtsZ 0.007 0 0.5
Schistosoma mansoni tubulin subunit alpha 0.0232 0.1611 0.1611
Giardia lamblia Beta tubulin 0.029 0.2188 0.6939
Trichomonas vaginalis tubulin alpha chain, putative 0.0092 0.0213 0.0676
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Brugia malayi Tubulin beta-1 chain 0.029 0.2188 0.2188
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0079 0.0089 0.0089
Echinococcus multilocularis tubulin alpha 1C chain 0.0232 0.1611 0.1611
Trichomonas vaginalis tubulin beta chain, putative 0.0232 0.1611 0.5109
Giardia lamblia Cathepsin B precursor 0.0387 0.3154 1
Entamoeba histolytica cysteine proteinase, putative 0.0294 0.2233 1
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0079 0.0089 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0079 0.0089 0.0281
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Echinococcus multilocularis cysteine protease 0.0294 0.2233 0.2233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0079 0.0089 0.0089
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0079 0.0089 0.0397
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1073 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.0958 0.3038
Echinococcus granulosus tubulin gamma 1 chain 0.0162 0.0916 0.0916
Plasmodium falciparum serine repeat antigen 1 0.0079 0.0089 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Echinococcus granulosus Tubulin beta 2C chain 0.029 0.2188 0.2188
Loa Loa (eye worm) hypothetical protein 0.0162 0.0908 0.0908
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0089 0.0281
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Leishmania major cysteine peptidase A (CPA) 0.0294 0.2233 0.7081
Trichomonas vaginalis tubulin epsilon chain, putative 0.0232 0.1611 0.5109
Trypanosoma brucei cysteine peptidase C (CPC) 0.0387 0.3154 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Loa Loa (eye worm) tubulin beta-4 chain 0.029 0.2188 0.2188
Onchocerca volvulus 0.0207 0.1364 0.5946
Toxoplasma gondii cathepsin CPC1 0.0079 0.0089 0.0281
Leishmania major cathepsin L-like protease 0.0294 0.2233 0.7081
Trichomonas vaginalis tubulin beta chain, putative 0.0232 0.1611 0.5109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.2233 0.7081
Plasmodium falciparum alpha tubulin 1 0.0232 0.1611 0.7214
Leishmania major beta tubulin 0.029 0.2188 0.6939
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0207 0.1364 0.4325
Echinococcus granulosus tubulin subunit beta 0.029 0.2188 0.2188
Trypanosoma cruzi major cysteine proteinase, putative 0.0079 0.0089 0.0089
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0079 0.0089 0.0397
Leishmania major cathepsin L-like protease 0.0294 0.2233 0.7081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0167 0.0958 0.3038
Trichomonas vaginalis tubulin beta chain, putative 0.0232 0.1611 0.5109
Plasmodium falciparum serine repeat antigen 9 0.0079 0.0089 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0092 0.0213 0.0676
Trichomonas vaginalis tubulin, putative 0.0092 0.0213 0.0676
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Onchocerca volvulus 0.0294 0.2233 1
Brugia malayi beta-tubulin, identical 0.029 0.2188 0.2188
Echinococcus multilocularis tubulin alpha chain 0.0232 0.1611 0.1611
Schistosoma mansoni alpha tubulin 0.0232 0.1611 0.1611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Plasmodium vivax tubulin alpha chain, putative 0.0232 0.1611 0.7214
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0167 0.0958 0.0958
Echinococcus granulosus beta tubulin 0.029 0.2188 0.2188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Schistosoma mansoni cathepsin s 0.0087 0.0166 0.0166
Loa Loa (eye worm) tubulin beta chain 0.029 0.2188 0.2188
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0387 0.3154 0.3154
Trichomonas vaginalis tubulin beta chain, putative 0.0232 0.1611 0.5109
Brugia malayi Papain family cysteine protease containing protein 0.0079 0.0089 0.0089
Trypanosoma brucei beta tubulin 0.029 0.2188 0.6939
Brugia malayi cathepsin F-like cysteine proteinase 0.0079 0.0089 0.0089
Leishmania major beta tubulin 0.029 0.2188 0.6939
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Brugia malayi Papain family cysteine protease containing protein 0.0167 0.0958 0.0958
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.2233 0.7081
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0079 0.0089 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Loa Loa (eye worm) tubulin beta-2A chain 0.029 0.2188 0.2188
Echinococcus granulosus tubulin alpha chain 0.0232 0.1611 0.1611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.2233 0.7081
Plasmodium vivax tubulin alpha chain, putative 0.0232 0.1611 0.7214
Trypanosoma brucei beta tubulin 0.0162 0.0916 0.2906
Leishmania major cathepsin L-like protease 0.0294 0.2233 0.7081
Plasmodium falciparum serine repeat antigen 8 0.0079 0.0089 0.0397
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Trichomonas vaginalis tubulin epsilon chain, putative 0.0232 0.1611 0.5109
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0079 0.0089 0.0281
Loa Loa (eye worm) ctsf protein 0.0294 0.2233 0.2233
Trypanosoma cruzi cysteine protease, putative 0.0167 0.0958 0.0958
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Trypanosoma brucei alpha tubulin 0.0232 0.1611 0.5109
Giardia lamblia Cathepsin L precursor 0.0079 0.0089 0.0281
Echinococcus granulosus cathepsin L 0.0079 0.0089 0.0089
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1073 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0294 0.2233 0.2233
Onchocerca volvulus Cathepsin L homolog 0.0294 0.2233 1
Echinococcus granulosus cathepsin b 0.1073 1 1
Loa Loa (eye worm) hypothetical protein 0.0232 0.1611 0.1611
Plasmodium vivax vivapain-3 0.0167 0.0958 0.429
Giardia lamblia Cathepsin B precursor 0.0079 0.0089 0.0281
Plasmodium falciparum tubulin epsilon chain, putative 0.0162 0.0916 0.4103
Echinococcus multilocularis cathepsin b 0.1073 1 1
Brugia malayi alpha-tubulin 0.0232 0.1611 0.1611
Leishmania major beta tubulin 0.029 0.2188 0.6939
Giardia lamblia Hypothetical protein 0.0079 0.0089 0.0281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0089 0.0281
Leishmania major beta tubulin 0.029 0.2188 0.6939
Plasmodium falciparum serine repeat antigen 4 0.0079 0.0089 0.0397
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0079 0.0089 0.0281
Loa Loa (eye worm) hypothetical protein 0.0207 0.1364 0.1364
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0079 0.0089 0.0089
Schistosoma mansoni tubulin subunit beta 0.029 0.2188 0.2188
Echinococcus granulosus Tubulin beta 2C chain 0.029 0.2188 0.2188
Leishmania major beta tubulin 0.029 0.2188 0.6939
Entamoeba histolytica tubulin family protein 0.029 0.2188 0.979
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0079 0.0089 0.0089
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0087 0.0166 0.0166
Brugia malayi Cathepsin L-like precursor 0.0207 0.1364 0.1364
Schistosoma mansoni alpha tubulin 0.0232 0.1611 0.1611
Loa Loa (eye worm) tubulin alpha 2 0.0162 0.0908 0.0908
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Mycobacterium leprae cell division protein FtsZ 0.007 0 0.5
Giardia lamblia Beta tubulin 0.029 0.2188 0.6939
Brugia malayi cathepsin Z-like cysteine proteinase 0.0079 0.0089 0.0089
Echinococcus granulosus Tubulin alpha 1 chain 0.0232 0.1611 0.1611
Schistosoma mansoni tubulin subunit beta 0.029 0.2188 0.2188
Entamoeba histolytica tubulin family protein 0.029 0.2188 0.979
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0387 0.3154 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0079 0.0089 0.0281
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0079 0.0089 0.0089
Echinococcus granulosus Tubulin beta 2C chain 0.029 0.2188 0.2188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Plasmodium vivax tubulin gamma chain, putative 0.0162 0.0916 0.4103
Echinococcus multilocularis peroxisome assembly protein 26 0.0232 0.1611 0.1611
Loa Loa (eye worm) hypothetical protein 0.0079 0.0089 0.0089
Giardia lamblia Cysteine protease 0.0079 0.0089 0.0281
Entamoeba histolytica cysteine proteinase, putative 0.0294 0.2233 1
Onchocerca volvulus 0.0294 0.2233 1
Loa Loa (eye worm) alpha-tubulin 0.0232 0.1611 0.1611
Plasmodium vivax unspecified product 0.0087 0.0166 0.0744
Echinococcus multilocularis cathepsin L cysteine protease 0.0294 0.2233 0.2233
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Loa Loa (eye worm) hypothetical protein 0.0079 0.0089 0.0089
Brugia malayi Cathepsin L-like precursor 0.0294 0.2233 0.2233
Brugia malayi Tubulin alpha-2 chain 0.0232 0.1611 0.1611
Plasmodium vivax tubulin epsilon chain, putative 0.0162 0.0916 0.4103
Echinococcus multilocularis tubulin alpha chain 0.0232 0.1611 0.1611
Trypanosoma brucei epsilon tubulin 0.0162 0.0916 0.2906
Echinococcus multilocularis cathepsin L 0.0079 0.0089 0.0089
Trichomonas vaginalis tubulin, putative 0.029 0.2188 0.6939
Trichomonas vaginalis tubulin alpha chain, putative 0.029 0.2188 0.6939
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0167 0.0958 0.3038
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0079 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0207 0.1364 0.4325
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.0958 0.4054
Leishmania major beta tubulin 0.029 0.2188 0.6939
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0294 0.2233 0.2233
Trichomonas vaginalis tubulin gamma chain, putative 0.0162 0.0916 0.2906
Loa Loa (eye worm) alpha-tubulin 0.0232 0.1611 0.1611
Echinococcus granulosus tubulin alpha chain 0.0232 0.1611 0.1611
Brugia malayi cathepsin Z-like cysteine proteinase 0.0079 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.2233 0.7081
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.0958 0.3038
Trichomonas vaginalis tubulin gamma chain, putative 0.0162 0.0916 0.2906
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Trypanosoma cruzi cysteine peptidase, putative 0.0294 0.2233 0.2233
Echinococcus granulosus tubulin subunit TubB 0.0232 0.1611 0.1611
Echinococcus multilocularis Tubulin alpha 1 chain 0.0232 0.1611 0.1611
Trypanosoma cruzi cruzipain precursor, putative 0.0294 0.2233 0.2233
Onchocerca volvulus 0.0294 0.2233 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0232 0.1611 0.1611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Loa Loa (eye worm) hypothetical protein 0.0207 0.1364 0.1364
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.2233 0.7081
Echinococcus multilocularis tubulin alpha chain 0.0232 0.1611 0.1611
Loa Loa (eye worm) hypothetical protein 0.0294 0.2233 0.2233
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.2233 0.7081
Echinococcus multilocularis cysteine protease 0.0294 0.2233 0.2233
Schistosoma mansoni tubulin subunit gamma 0.0162 0.0916 0.0916
Echinococcus multilocularis beta tubulin 0.029 0.2188 0.2188
Leishmania major beta tubulin 0.029 0.2188 0.6939
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0079 0.0089 0.0281
Echinococcus multilocularis tubulin epsilon chain 0.0162 0.0916 0.0916
Entamoeba histolytica tubulin alpha chain, putative 0.0232 0.1611 0.7099
Giardia lamblia Alpha-tubulin 0.0232 0.1611 0.5109
Echinococcus granulosus alpha tubulin 0.0232 0.1611 0.1611
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0079 0.0089 0.0397
Trypanosoma cruzi cysteine peptidase, putative 0.0294 0.2233 0.2233
Brugia malayi Tubulin beta chain 0.0092 0.0213 0.0213
Leishmania major cathepsin L-like protease 0.0294 0.2233 0.7081
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0079 0.0089 0.0281
Toxoplasma gondii alpha tubulin TUBA1 0.0232 0.1611 0.5109
Echinococcus granulosus tubulin alpha chain 0.0232 0.1611 0.1611
Brugia malayi cathepsin L-like precursor 0.0207 0.1364 0.1364
Echinococcus granulosus Tubulin beta 2C chain 0.029 0.2188 0.2188
Echinococcus granulosus tubulin beta 4A class IVa 0.029 0.2188 0.2188
Leishmania major beta tubulin 0.029 0.2188 0.6939
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0079 0.0089 0.0089
Echinococcus multilocularis tubulin alpha chain 0.0232 0.1611 0.1611
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0294 0.2233 0.2233
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0387 0.3154 0.3154
Giardia lamblia Encystation-specific protease 0.0079 0.0089 0.0281
Entamoeba histolytica cysteine protease, putative 0.0294 0.2233 1
Brugia malayi Cathepsin L-like precursor 0.0294 0.2233 0.2233
Brugia malayi cathepsin L precursor 0.0079 0.0089 0.0089
Leishmania major cathepsin L-like protease 0.0294 0.2233 0.7081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0089 0.0281
Loa Loa (eye worm) hypothetical protein 0.0087 0.0166 0.0166
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Echinococcus multilocularis cathepsin L cysteine protease 0.0294 0.2233 0.2233
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0079 0.0089 0.0281
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Trypanosoma brucei epsilon tubulin 0.0162 0.0916 0.2906
Leishmania major beta tubulin 0.029 0.2188 0.6939
Plasmodium vivax unspecified product 0.0079 0.0089 0.0397
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0079 0.0089 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Leishmania major epsilon tubulin, putative 0.0162 0.0916 0.2906
Entamoeba histolytica tubulin gamma chain 0.0162 0.0916 0.3859
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1073 1 1
Leishmania major gamma-tubulin 0.0162 0.0916 0.2906
Plasmodium falciparum serine repeat antigen 2 0.0079 0.0089 0.0397
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0162 0.0908 0.0908
Giardia lamblia Cathepsin B precursor 0.0079 0.0089 0.0281
Plasmodium vivax vivapain-1 0.0167 0.0958 0.429
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0207 0.1364 0.1364
Trypanosoma cruzi alpha tubulin, putative 0.0232 0.1611 0.1611
Echinococcus multilocularis tubulin alpha 3 chain 0.0232 0.1611 0.1611
Giardia lamblia Cathepsin L precursor 0.0079 0.0089 0.0281
Schistosoma mansoni cathepsin F (C01 family) 0.0207 0.1364 0.1364
Giardia lamblia Cysteine protease 0.0079 0.0089 0.0281
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0294 0.2233 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0087 0.0166 0.0166
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Echinococcus granulosus Tubulin alpha 1 chain 0.0232 0.1611 0.1611
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0079 0.0089 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0294 0.2233 0.7081
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0294 0.2233 1
Schistosoma mansoni cathepsin B (C01 family) 0.0079 0.0089 0.0089
Brugia malayi Cathepsin L-like precursor 0.0294 0.2233 0.2233
Schistosoma mansoni tubulin subunit beta 0.029 0.2188 0.2188
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Mycobacterium ulcerans cell division protein FtsZ 0.007 0 0.5
Echinococcus granulosus peroxisome assembly protein 26 0.0232 0.1611 0.1611
Plasmodium falciparum serine repeat antigen 5 0.0079 0.0089 0.0397
Trypanosoma brucei alpha tubulin, putative 0.0092 0.0213 0.0676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0089 0.0281
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Schistosoma mansoni alpha tubulin 0.0232 0.1611 0.1611
Echinococcus granulosus tubulin alpha 1C chain 0.0232 0.1611 0.1611
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Trypanosoma brucei alpha tubulin 0.0232 0.1611 0.5109
Echinococcus multilocularis beta tubulin 0.029 0.2188 0.2188
Onchocerca volvulus 0.0092 0.0213 0.0581
Giardia lamblia Cathepsin B precursor 0.0079 0.0089 0.0281
Plasmodium vivax serine-repeat antigen (SERA) 0.0079 0.0089 0.0397
Trypanosoma brucei alpha tubulin 0.0232 0.1611 0.5109
Trypanosoma brucei beta tubulin 0.029 0.2188 0.6939
Echinococcus granulosus tubulin alpha chain 0.0232 0.1611 0.1611
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0079 0.0089 0.0281
Giardia lamblia Cathepsin L precursor 0.0079 0.0089 0.0281
Trypanosoma cruzi cysteine proteinase, putative 0.0167 0.0958 0.0958
Echinococcus multilocularis Tubulin beta 2C chain 0.029 0.2188 0.2188
Leishmania major beta tubulin 0.029 0.2188 0.6939
Brugia malayi Cathepsin L-like precursor 0.0207 0.1364 0.1364
Echinococcus multilocularis Tubulin beta 2C chain 0.029 0.2188 0.2188
Trypanosoma cruzi beta tubulin, putative 0.029 0.2188 0.2188
Toxoplasma gondii cathepsin B 0.0387 0.3154 1
Trypanosoma brucei tubulin gamma chain 0.0162 0.0916 0.2906
Echinococcus multilocularis tubulin beta 1 chain 0.029 0.2188 0.2188
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0079 0.0089 0.0397
Loa Loa (eye worm) tubulin alpha-2 chain 0.0232 0.1611 0.1611
Echinococcus granulosus beta tubulin 0.029 0.2188 0.2188
Toxoplasma gondii beta tubulin 0.029 0.2188 0.6939
Onchocerca volvulus 0.0294 0.2233 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0166 0.0166
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0079 0.0089 0.0397
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0079 0.0089 0.0089
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0079 0.0089 0.0281
Loa Loa (eye worm) hypothetical protein 0.0079 0.0089 0.0089
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0167 0.0958 0.0958
Brugia malayi cathepsin L-like cysteine proteinase 0.0079 0.0089 0.0089
Leishmania major beta tubulin 0.029 0.2188 0.6939
Trypanosoma cruzi cysteine proteinase, putative 0.0167 0.0958 0.0958
Trypanosoma cruzi major cysteine proteinase, putative 0.0079 0.0089 0.0089
Giardia lamblia Cysteine protease 0.0079 0.0089 0.0281
Echinococcus granulosus cathepsin l1 0.0294 0.2233 0.2233
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.0958 0.4054
Plasmodium falciparum tubulin gamma chain 0.0162 0.0916 0.4103
Echinococcus granulosus tubulin alpha 0.0162 0.0916 0.0916
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0089 0.0281
Echinococcus multilocularis Tubulin alpha 1 chain 0.0232 0.1611 0.1611
Echinococcus granulosus tubulin epsilon chain 0.0162 0.0916 0.0916
Toxoplasma gondii alpha-tubulin I, putative 0.0232 0.1611 0.5109
Leishmania major beta tubulin 0.029 0.2188 0.6939
Echinococcus granulosus Tubulin beta 2C chain 0.029 0.2188 0.2188
Echinococcus granulosus Tubulin alpha 1 chain 0.0232 0.1611 0.1611
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Trichomonas vaginalis tubulin alpha chain, putative 0.0092 0.0213 0.0676
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Loa Loa (eye worm) cathepsin B 0.0387 0.3154 0.3154
Giardia lamblia Cathepsin B precursor 0.0079 0.0089 0.0281
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0089 0.0281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Trypanosoma cruzi cysteine peptidase, putative 0.0294 0.2233 0.2233
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0162 0.0916 0.2906
Giardia lamblia Gamma tubulin 0.0162 0.0916 0.2906
Schistosoma mansoni tubulin subunit epsilon 0.0162 0.0916 0.0916
Schistosoma mansoni cathepsin S (C01 family) 0.0079 0.0089 0.0089
Onchocerca volvulus 0.0294 0.2233 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.2233 0.7081
Echinococcus multilocularis Tubulin alpha 1 chain 0.0232 0.1611 0.1611
Plasmodium falciparum serine repeat antigen 6 0.0079 0.0089 0.0397
Trypanosoma cruzi cysteine peptidase, putative 0.0087 0.0166 0.0166
Echinococcus multilocularis Tubulin beta 2C chain 0.029 0.2188 0.2188
Trypanosoma cruzi cruzipain precursor, putative 0.0087 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0087 0.0166 0.0166
Schistosoma mansoni tubulin subunit beta 0.029 0.2188 0.2188
Giardia lamblia Beta tubulin 0.029 0.2188 0.6939
Echinococcus granulosus tubulin alpha 1C chain 0.0232 0.1611 0.1611
Echinococcus granulosus cathepsin l1 0.0207 0.1364 0.1364
Trichomonas vaginalis tubulin beta chain, putative 0.0232 0.1611 0.5109
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0079 0.0089 0.0397
Loa Loa (eye worm) tubulin alpha chain 0.0232 0.1611 0.1611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.2233 0.7081
Giardia lamblia Cathepsin B precursor 0.0387 0.3154 1
Toxoplasma gondii beta-tubulin, putative 0.029 0.2188 0.6939
Trypanosoma cruzi epsilon tubulin, putative 0.0162 0.0916 0.0916
Trichomonas vaginalis tubulin beta chain, putative 0.0232 0.1611 0.5109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0089 0.0281
Trypanosoma brucei beta tubulin 0.029 0.2188 0.6939
Trichomonas vaginalis tubulin gamma chain, putative 0.029 0.2188 0.6939
Echinococcus granulosus cysteine protease 0.0167 0.0958 0.0958
Loa Loa (eye worm) hypothetical protein 0.0207 0.1364 0.1364
Onchocerca volvulus 0.0294 0.2233 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0294 0.2233 0.2233
Leishmania major cathepsin L-like protease 0.0294 0.2233 0.7081
Trypanosoma cruzi cysteine peptidase, putative 0.0294 0.2233 0.2233
Plasmodium falciparum cysteine proteinase falcipain 1 0.0167 0.0958 0.429
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0089 0.0281
Giardia lamblia Cathepsin B precursor 0.0387 0.3154 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0079 0.0089 0.0397
Trypanosoma brucei alpha tubulin 0.0232 0.1611 0.5109
Loa Loa (eye worm) BEN-1 protein 0.029 0.2188 0.2188
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1073 1 1
Plasmodium falciparum serine repeat antigen 3 0.0079 0.0089 0.0397
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0079 0.0089 0.0397
Echinococcus multilocularis cathepsin b 0.1073 1 1
Plasmodium falciparum serine repeat antigen 7 0.0079 0.0089 0.0397
Plasmodium vivax unspecified product 0.0167 0.0958 0.429
Leishmania major beta tubulin 0.029 0.2188 0.6939
Leishmania major cathepsin L-like protease 0.0294 0.2233 0.7081
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0079 0.0089 0.0397
Echinococcus granulosus cathepsin L cysteine protease 0.0167 0.0958 0.0958
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Plasmodium vivax tubulin beta chain, putative 0.029 0.2188 0.9798
Brugia malayi Papain family cysteine protease containing protein 0.0294 0.2233 0.2233
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0079 0.0089 0.0089
Entamoeba histolytica cysteine proteinase 1, putative 0.0167 0.0958 0.4054
Brugia malayi Tubulin alpha chain 0.0232 0.1611 0.1611
Onchocerca volvulus 0.0294 0.2233 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0089 0.0089
Plasmodium vivax serine-repeat antigen (SERA) 0.0079 0.0089 0.0397
Trypanosoma brucei beta tubulin 0.029 0.2188 0.6939
Plasmodium vivax vivapain-2 0.0294 0.2233 1
Toxoplasma gondii beta-1 tubulin, putative 0.029 0.2188 0.6939
Echinococcus multilocularis tubulin subunit beta 0.029 0.2188 0.2188
Loa Loa (eye worm) BEN-1 protein 0.029 0.2188 0.2188
Toxoplasma gondii preprocathepsin c precursor, putative 0.0079 0.0089 0.0281
Giardia lamblia Cathepsin L-like protease 0.0079 0.0089 0.0281
Loa Loa (eye worm) tubulin beta-1 chain 0.029 0.2188 0.2188
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0167 0.0958 0.0958
Loa Loa (eye worm) tubulin gamma chain 0.0162 0.0916 0.0916
Loa Loa (eye worm) fibroinase 0.0294 0.2233 0.2233
Brugia malayi Tubulin alpha-2 chain 0.0232 0.1611 0.1611
Plasmodium falciparum cysteine proteinase falcipain 3 0.0294 0.2233 1
Giardia lamblia Cathepsin L-like protease 0.0079 0.0089 0.0281
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0079 0.0089 0.0281
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0089 0.0281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Giardia lamblia Cysteine protease 0.0079 0.0089 0.0281
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0167 0.0958 0.0958
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0087 0.0166 0.0166
Brugia malayi tubulin alpha-2 chain 0.0232 0.1611 0.1611
Brugia malayi Cathepsin L-like precursor 0.0294 0.2233 0.2233
Trichomonas vaginalis tubulin alpha chain, putative 0.0162 0.0916 0.2906
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0079 0.0089 0.0089
Entamoeba histolytica cysteine proteinase, putative 0.0207 0.1364 0.5946
Giardia lamblia Cathepsin L precursor 0.0079 0.0089 0.0281
Loa Loa (eye worm) tubulin alpha 2 0.0162 0.0908 0.0908
Echinococcus multilocularis tubulin alpha chain 0.0232 0.1611 0.1611
Echinococcus granulosus cathepsin L 0.0167 0.0958 0.0958
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.014 0.0695 0.2203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0089 0.0281
Echinococcus multilocularis tubulin, beta 4A class IVa 0.029 0.2188 0.2188
Brugia malayi Cathepsin L-like precursor 0.0294 0.2233 0.2233
Brugia malayi Papain family cysteine protease containing protein 0.0079 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0079 0.0089 0.0089
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0089 0.0281
Giardia lamblia Cathepsin B precursor 0.0079 0.0089 0.0281
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0079 0.0089 0.0089
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0079 0.0089 0.0397
Schistosoma mansoni cathepsin C 0.0079 0.0089 0.0089
Trypanosoma cruzi epsilon tubulin, putative 0.0162 0.0916 0.0916
Echinococcus granulosus tubulin beta 1 chain 0.029 0.2188 0.2188
Toxoplasma gondii cathepsin CPC2 0.0079 0.0089 0.0281
Echinococcus granulosus tubulin alpha 3 chain 0.0232 0.1611 0.1611
Loa Loa (eye worm) hypothetical protein 0.014 0.0695 0.0695
Leishmania major cathepsin L-like protease 0.0294 0.2233 0.7081
Leishmania major beta tubulin 0.029 0.2188 0.6939
Leishmania major beta tubulin 0.029 0.2188 0.6939
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.007 0 0.5
Trypanosoma cruzi tubulin gamma chain 0.0162 0.0916 0.0916
Trichomonas vaginalis tubulin, putative 0.0092 0.0213 0.0676
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Echinococcus multilocularis hypothetical protein 0.0232 0.1611 0.1611
Brugia malayi Papain family cysteine protease containing protein 0.0079 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0079 0.0089 0.0089
Echinococcus granulosus tubulin alpha chain 0.0232 0.1611 0.1611
Loa Loa (eye worm) tubulin alpha-3 chain 0.014 0.0695 0.0695
Plasmodium vivax vivapain-2 0.0294 0.2233 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0232 0.1611 0.1611
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0387 0.3154 1
Loa Loa (eye worm) tubulin alpha chain 0.0232 0.1611 0.1611
Trichomonas vaginalis tubulin beta chain, putative 0.029 0.2188 0.6939
Echinococcus multilocularis cathepsin L 0.0167 0.0958 0.0958
Schistosoma mansoni cathepsin F (C01 family) 0.0294 0.2233 0.2233
Echinococcus granulosus tubulin alpha 3 chain 0.0232 0.1611 0.1611
Leishmania major beta tubulin 0.029 0.2188 0.6939
Trypanosoma cruzi cysteine peptidase, putative 0.0167 0.0958 0.0958
Echinococcus multilocularis tubulin gamma 1 chain 0.0162 0.0916 0.0916
Giardia lamblia Cathepsin L precursor 0.0079 0.0089 0.0281
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0079 0.0089 0.0281
Giardia lamblia Hypothetical protein 0.0079 0.0089 0.0281
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0294 0.2233 0.2233
Plasmodium falciparum alpha tubulin 2 0.0232 0.1611 0.7214
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.0958 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Brugia malayi Cathepsin L-like precursor 0.0294 0.2233 0.2233
Brugia malayi fibroinase precursor 0.0079 0.0089 0.0089

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) < 0.01 uM Cytotoxicity against human MCF7 cells by SRB assay ChEMBL. 26257861
IC50 (functional) = 63.7 nM Growth inhibition of colon 26 adenocarcinoma cells by 50 %. ChEMBL. 9685242
IC50 (functional) = 63.7 nM Growth inhibition of colon 26 adenocarcinoma cells by 50 %. ChEMBL. 9685242
IC50 (binding) > 20 uM Inhibitory activity against tubulin polymerization ChEMBL. 9685242
IC50 (binding) > 20 uM Inhibitory activity against tubulin polymerization ChEMBL. 9685242

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 9685242

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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