TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 332.359 | Formula: C18H16N6O
H donors: 1 H acceptors: 6 LogP: 2.58 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Oc1nc2cc3ccccc3cc2nc1c1nnnn1C1CCCC1
InChi: 1S/C18H16N6O/c25-18-16(17-21-22-23-24(17)13-7-3-4-8-13)19-14-9-11-5-1-2-6-12(11)10-15(14)20-18/h1-2,5-6,9-10,13H,3-4,7-8H2,(H,20,25)
InChiKey: SBUBHACETLZRAF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	isocitrate dehydrogenase 1 (NADP+), soluble	Starlite/ChEMBL	No references
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references
Homo sapiens	SUMO1/sentrin specific peptidase 1	Starlite/ChEMBL	No references
Homo sapiens	EYA transcriptional coactivator and phosphatase 2	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Theileria parva	hypothetical protein	Get druggable targets OG5_127954	All targets in OG5_127954
Plasmodium yoelii	similar to sentrin/SUMO-specific protease	Get druggable targets OG5_127954	All targets in OG5_127954
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	Ulp1 protease family, C-terminal catalytic domain-containing protein	Get druggable targets OG5_127954	All targets in OG5_127954
Loa Loa (eye worm)	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	C terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127954	All targets in OG5_127954
Neospora caninum	Isocitrate dehydrogenase-like protein, related	Get druggable targets OG5_127057	All targets in OG5_127057
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_127954	All targets in OG5_127954
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	Get druggable targets OG5_127954	All targets in OG5_127954
Neospora caninum	hypothetical protein	Get druggable targets OG5_127954	All targets in OG5_127954
Trypanosoma brucei	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	eyes absent homolog	Get druggable targets OG5_129664	All targets in OG5_129664
Schistosoma japonicum	ko:K01104 protein-tyrosine phosphatase [EC3.1.3.48], putative	Get druggable targets OG5_129664	All targets in OG5_129664
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium knowlesi	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania braziliensis	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	one of three potential ubiquitin-like protein-specific protease genes	Get druggable targets OG5_127954	All targets in OG5_127954
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium berghei	sentrin-specific protease 1, putative	Get druggable targets OG5_127954	All targets in OG5_127954
Plasmodium falciparum	sentrin-specific protease 1	Get druggable targets OG5_127954	All targets in OG5_127954
Plasmodium vivax	sentrin-specific protease 1, putative	Get druggable targets OG5_127954	All targets in OG5_127954
Trypanosoma brucei gambiense	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129664	All targets in OG5_129664
Trypanosoma cruzi	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania infantum	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129664	All targets in OG5_129664
Neospora caninum	hypothetical protein	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	Get druggable targets OG5_127954	All targets in OG5_127954
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	Get druggable targets OG5_127954	All targets in OG5_127954
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Theileria parva	isocitrate dehydrogenase (NADP+), putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania mexicana	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K08592 sentrin-specific protease 1, putative	Get druggable targets OG5_127954	All targets in OG5_127954
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium knowlesi	sentrin-specific protease 1, putative	Get druggable targets OG5_127954	All targets in OG5_127954
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	Get druggable targets OG5_127954	All targets in OG5_127954
Echinococcus granulosus	sentrin specific protease 1	Get druggable targets OG5_127954	All targets in OG5_127954
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	sentrin specific protease 1	Get druggable targets OG5_127954	All targets in OG5_127954
Candida albicans	N terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania donovani	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium berghei	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	hypothetical protein	Get druggable targets OG5_129664	All targets in OG5_129664
Brugia malayi	Isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	one of three potential ubiquitin-like protein-specific protease genes	Get druggable targets OG5_127954	All targets in OG5_127954
Brugia malayi	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Babesia bovis	isocitrate dehydrogenase, NADP-dependent family protein	Get druggable targets OG5_127057	All targets in OG5_127057
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	Get druggable targets OG5_127954	All targets in OG5_127954
Candida albicans	cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Babesia bovis	ulp1 protease family, C-terminal catalytic domain containing protein	Get druggable targets OG5_127954	All targets in OG5_127954
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Cryptosporidium parvum	ULP1 like chllamydin domain containing protease	Get druggable targets OG5_127954	All targets in OG5_127954

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0554	0.0974
Giardia lamblia	DINP protein human, muc B family	0.0136	0.1774	0.3211
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0043	0.0385	0.0666
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0041	0.0366	0.0632
Brugia malayi	phosphofructokinase	0.0122	0.1562	0.2804
Schistosoma mansoni	flap endonuclease-1	0.0054	0.0548	0.0963
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0182	0.2453	0.2453
Schistosoma mansoni	DNA polymerase IV / kappa	0.0038	0.0308	0.0528
Mycobacterium leprae	Probable phosphoglycerate kinase Pgk	0.0388	0.5526	1
Echinococcus granulosus	lysosomal alpha glucosidase	0.0189	0.2562	0.4619
Echinococcus multilocularis	6 phosphofructokinase	0.0122	0.1562	0.2804
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0121	0.1551	0.2806
Plasmodium vivax	ubiquitin activating enzyme, putative	0.0054	0.0553	0.0946
Mycobacterium tuberculosis	Probable phosphoglycerate kinase Pgk	0.0388	0.5526	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0098	0.1211	0.1181
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0042	0.0373	0.0619
Loa Loa (eye worm)	6-phosphofructokinase	0.0122	0.1562	0.2804
Toxoplasma gondii	phosphoglycerate kinase PGKII	0.0388	0.5526	1
Leishmania major	ubiquitin-activating enzyme-like protein	0.0036	0.0278	0.0246
Schistosoma mansoni	eukaryotic translation initiation factor 4h	0.0151	0.1997	0.3594
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0043	0.0385	0.0666
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0104	0.1302	0.2331
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0366	0.0662
Schistosoma mansoni	hypothetical protein	0.0042	0.037	0.064
Echinococcus granulosus	ubiquitin specific protease 41	0.0041	0.0366	0.0632
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0189	0.2562	0.4619
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0054	0.0554	0.0471
Trypanosoma brucei	DNA polymerase kappa, putative	0.0098	0.1215	0.1186
Echinococcus multilocularis	phosphoglycerate kinase 1	0.0388	0.5526	1
Trichomonas vaginalis	DNA helicase recq, putative	0.0055	0.0571	0.1034
Echinococcus multilocularis	histone lysine N methyltransferase NSD3	0.0038	0.0315	0.054
Trichomonas vaginalis	DNA helicase recq1, putative	0.0103	0.1288	0.2331
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0041	0.0366	0.0632
Mycobacterium ulcerans	acyl-CoA synthetase	0.0054	0.0554	0.0471
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0091	0.1101	0.1944
Plasmodium falciparum	SUMO-activating enzyme subunit 1	0.0054	0.0553	0.0946
Entamoeba histolytica	phosphofructokinase, putative	0.0122	0.1562	0.2827
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0054	0.0554	0.0471
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0038	0.0308	0.05
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0182	0.2453	0.2453
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0042	0.0373	0.0676
Chlamydia trachomatis	phosphoglycerate kinase	0.0388	0.5526	1
Brugia malayi	Flap endonuclease-1	0.0059	0.0633	0.1117
Mycobacterium ulcerans	hypothetical protein	0.0054	0.0554	0.0471
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0096	0.1173	0.2075
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0033	0.0239	0.0432
Trypanosoma brucei	DNA polymerase kappa, putative	0.0182	0.2453	0.2428
Loa Loa (eye worm)	ThiF family protein	0.0036	0.0278	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0554	0.0974
Trypanosoma brucei	DNA polymerase kappa, putative	0.0182	0.2453	0.2428
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0038	0.0318	0.0517
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0033	0.0028
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0104	0.1302	0.2331
Brugia malayi	glutaminase DH11.1	0.0306	0.4308	0.7789
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0121	0.1551	0.2783
Brugia malayi	Phosphoglycerate kinase	0.0388	0.5526	1
Toxoplasma gondii	phosphofructokinase PFKII	0.0033	0.0239	0.0374
Echinococcus granulosus	sentrin specific protease 1	0.0056	0.0587	0.1034
Echinococcus multilocularis	ubiquitin specific protease 41	0.0041	0.0366	0.0632
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.016	0.213	0.317
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0022	0.0073	0.0072
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0041	0.0366	0.0632
Entamoeba histolytica	hypothetical protein	0.0042	0.037	0.067
Echinococcus granulosus	geminin	0.019	0.2575	0.4643
Loa Loa (eye worm)	hypothetical protein	0.004	0.035	0.0604
Toxoplasma gondii	phosphoglycerate kinase PGKI	0.0388	0.5526	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0043	0.0388	0.0355
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0033	0.0029
Brugia malayi	RNA binding protein	0.0151	0.1997	0.3594
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0306	0.0554
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0182	0.2453	0.4439
Brugia malayi	hypothetical protein	0.002	0.0042	0.0044
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.037	0.064
Schistosoma mansoni	hypothetical protein	0.0019	0.0033	0.0028
Trypanosoma brucei	DNA polymerase kappa, putative	0.0098	0.1211	0.1181
Loa Loa (eye worm)	glutaminase	0.0306	0.4308	0.7789
Toxoplasma gondii	hypothetical protein	0.0054	0.0553	0.0946
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0104	0.1302	0.2331
Plasmodium vivax	phosphoglycerate kinase, putative	0.0388	0.5526	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0179	0.2415	0.239
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0388	0.5526	0.5526
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0056	0.0587	0.1034
Trichomonas vaginalis	DNA polymerase eta, putative	0.0182	0.2453	0.4439
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0033	0.0028
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0043	0.0388	0.0388
Trypanosoma brucei	DNA polymerase kappa, putative	0.0182	0.2453	0.2428
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0554	0.0974
Entamoeba histolytica	recQ family helicase, putative	0.0055	0.0571	0.1034
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1211	0.2166
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0038	0.0318	0.0517
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0142	0.187	0.187
Entamoeba histolytica	hypothetical protein	0.0042	0.037	0.067
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0042	0.0373	0.0676
Mycobacterium ulcerans	acyl-CoA synthetase	0.0054	0.0554	0.0471
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0019	0.0033	0.0029
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0142	0.187	0.1842
Echinococcus multilocularis	expressed protein	0.0037	0.0306	0.0524
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0043	0.0388	0.0152
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0122	0.1562	0.273
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0308	0.0308
Leishmania major	hypothetical protein, conserved	0.003	0.0203	0.017
Trypanosoma brucei	DNA polymerase kappa, putative	0.0182	0.2453	0.2428
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0056	0.0587	0.1034
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0043	0.0388	0.0645
Trypanosoma cruzi	3-phosphoglycerate kinase, glycosomal	0.0142	0.187	0.187
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0043	0.0388	0.0645
Brugia malayi	AMP-binding enzyme family protein	0.0054	0.0554	0.0974
Schistosoma mansoni	eyes absent homolog	0.0106	0.1334	0.2391
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0388	0.5526	1
Toxoplasma gondii	hypothetical protein	0.0111	0.1403	0.2493
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0038	0.0318	0.0517
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0189	0.2562	0.4619
Trichomonas vaginalis	phosphofructokinase, putative	0.0122	0.1562	0.2827
Loa Loa (eye worm)	flap endonuclease-1	0.0059	0.0633	0.1117
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.4623	0.8367
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0043	0.0385	0.0666
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.4623	0.8367
Loa Loa (eye worm)	hypothetical protein	0.003	0.0203	0.0336
Schistosoma mansoni	phosphoglycerate kinase	0.0388	0.5526	1
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0033	0.0239	0.0432
Giardia lamblia	Sgs1 DNA helicase, putative	0.0043	0.0385	0.0696
Trypanosoma brucei	DNA polymerase kappa, putative	0.0182	0.2453	0.2428
Schistosoma mansoni	alpha-glucosidase	0.0163	0.217	0.3908
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0041	0.0366	0.0632
Trichomonas vaginalis	DNA helicase recq, putative	0.0103	0.1288	0.2331
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0189	0.2562	0.4619
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0054	0.0554	0.0471
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0043	0.0388	0.0671
Brugia malayi	hypothetical protein	0.003	0.0203	0.0336
Schistosoma mansoni	glutaminase	0.0306	0.4308	0.7789
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0059	0.0633	0.0602
Schistosoma mansoni	eukaryotic translation initiation factor 4h	0.0151	0.1997	0.3594
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0054	0.0554	0.0471
Brugia malayi	Bloom's syndrome protein homolog	0.0103	0.1288	0.2307
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0033	0.0028
Toxoplasma gondii	6-phosphofructokinase	0.0033	0.0239	0.0374
Trypanosoma brucei	DNA polymerase kappa, putative	0.0098	0.1215	0.1186
Echinococcus multilocularis	sentrin specific protease 1	0.0056	0.0587	0.1034
Echinococcus granulosus	dna polymerase eta	0.0179	0.2415	0.4353
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0688	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0182	0.2453	0.2428
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0688	1	1
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0037	0.0306	0.0524
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0041	0.0366	0.0366
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0043	0.0388	0.0645
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0041	0.0366	0.0632
Loa Loa (eye worm)	phosphofructokinase	0.0122	0.1562	0.2804
Echinococcus granulosus	GPCR family 2	0.0019	0.0033	0.0028
Entamoeba histolytica	acyl-coA synthetase, putative	0.0054	0.0554	0.1002
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0122	0.1562	0.1534
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0121	0.1551	0.2783
Trypanosoma cruzi	ubiquitin-activating enzyme, putative	0.0036	0.0278	0.0278
Schistosoma mansoni	ap endonuclease	0.0043	0.0388	0.0671
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0239	0.0432
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0043	0.0385	0.0666
Leishmania major	4-coumarate:coa ligase-like protein	0.0054	0.0554	0.0522
Trichomonas vaginalis	rotamase, putative	0.0037	0.0293	0.053
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0104	0.1302	0.2331
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0121	0.1551	0.2783
Plasmodium vivax	6-phosphofructokinase, putative	0.0033	0.0239	0.0374
Trichomonas vaginalis	phosphofructokinase, putative	0.0122	0.1562	0.2827
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0033	0.0028
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0121	0.1551	0.2783
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0121	0.1551	0.2762
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0069	0.0777	0.1355
Mycobacterium ulcerans	phosphoglycerate kinase	0.0388	0.5526	1
Mycobacterium ulcerans	DNA polymerase IV	0.0182	0.2453	0.4111
Echinococcus multilocularis	geminin	0.019	0.2575	0.4643
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0203	0.0308
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0037	0.0293	0.0293
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0055	0.0571	0.0571
Leishmania major	phosphoglycerate kinase B, cytosolic	0.0388	0.5526	0.5511
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0373	0.0676
Plasmodium falciparum	flap endonuclease 1	0.0059	0.0633	0.1092
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0362	0.0626
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0033	0.0028
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0043	0.0385	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0587	0.1034
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.004	0.035	0.0081
Mycobacterium ulcerans	hypothetical protein	0.0362	0.5149	0.9277
Trypanosoma brucei	DNA polymerase kappa, putative	0.0098	0.1215	0.1186
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0373	0.0676
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0043	0.0385	0.0639
Loa Loa (eye worm)	hypothetical protein	0.004	0.035	0.0604
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0373	0.0676
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0182	0.2453	0.2453
Brugia malayi	ThiF family protein	0.0054	0.0553	0.0972
Leishmania major	4-coumarate:coa ligase-like protein	0.0054	0.0554	0.0522
Plasmodium vivax	acyl-CoA synthetase, putative	0.004	0.035	0.0577
Echinococcus granulosus	Eukaryotic translation initiation factor 4H	0.0151	0.1997	0.3594
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0033	0.0033
Trypanosoma brucei	DNA polymerase kappa, putative	0.0182	0.2453	0.2428
Echinococcus granulosus	SUMO activating enzyme subunit 1	0.0054	0.0553	0.0972
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0033	0.0239	0.0374
Schistosoma mansoni	ap endonuclease	0.0043	0.0388	0.0671
Schistosoma mansoni	6-phosphofructokinase	0.0122	0.1562	0.2804
Trichomonas vaginalis	phosphofructokinase, putative	0.0122	0.1562	0.2827
Toxoplasma gondii	peptidylprolyl isomerase	0.0037	0.0293	0.0473
Plasmodium vivax	sentrin-specific protease 1, putative	0.0056	0.0587	0.1008
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0308	0.0276
Echinococcus granulosus	flap endonuclease 1	0.0059	0.0633	0.1117
Echinococcus granulosus	dna polymerase kappa	0.0182	0.2453	0.4421
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0043	0.0385	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1997	0.3594
Trypanosoma brucei	DNA polymerase IV, putative	0.0182	0.2453	0.2428
Echinococcus multilocularis	dna polymerase kappa	0.0182	0.2453	0.4421
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.016	0.213	0.3818
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0326	0.4601	0.4601
Treponema pallidum	fructose-bisphosphate aldolase	0.0327	0.4623	0.8345
Schistosoma mansoni	sumo-1-activating enzyme E1a	0.0049	0.0479	0.0838
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.4623	0.8367
Trypanosoma brucei	unspecified product	0.0083	0.0991	0.0961
Trichomonas vaginalis	glutaminase, putative	0.0306	0.4308	0.7796
Echinococcus multilocularis	flap endonuclease 1	0.0059	0.0633	0.1117
Schistosoma mansoni	DNA polymerase eta	0.0179	0.2415	0.4353
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0056	0.0587	0.1063
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0055	0.0571	0.054
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0033	0.0028
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0043	0.0388	0.0701
Loa Loa (eye worm)	hypothetical protein	0.004	0.035	0.0604
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0041	0.0366	0.0366
Trypanosoma brucei	DNA polymerase IV, putative	0.0166	0.2229	0.2203
Loa Loa (eye worm)	RecQ helicase	0.0103	0.1288	0.2307
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0104	0.1302	0.2331
Schistosoma mansoni	hypothetical protein	0.019	0.2575	0.4643
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0388	0.5526	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.4623	0.8367
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0142	0.187	0.187
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0022	0.0073	0.0073
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0182	0.2453	0.2453
Schistosoma mansoni	hypothetical protein	0.0019	0.0033	0.0028
Giardia lamblia	Flap structure-specific endonuclease	0.0059	0.0633	0.1146
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0043	0.0388	0.0701
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0037	0.0306	0.0524
Leishmania major	DNA damage repair protein, putative	0.0038	0.0308	0.0276
Trypanosoma brucei	phosphoglycerate kinase	0.0142	0.187	0.1842
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.4623	0.8367
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0239	0.0432
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0097	0.1191	0.1191
Toxoplasma gondii	Ulp1 protease family, C-terminal catalytic domain-containing protein	0.0056	0.0587	0.1008
Schistosoma mansoni	6-phosphofructokinase	0.0122	0.1562	0.2804
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0122	0.1562	0.2027
Schistosoma mansoni	DNA helicase recq5	0.0043	0.0385	0.0666
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0042	0.0373	0.0676
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0054	0.0554	0.0948
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.4623	0.8367
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0022	0.0073	0.0073
Echinococcus granulosus	expressed protein	0.0037	0.0306	0.0524
Entamoeba histolytica	phosphoglycerate kinase, putative	0.0388	0.5526	1
Plasmodium vivax	DNA repair protein REV1, putative	0.0038	0.0308	0.05
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0041	0.0366	0.0632
Plasmodium vivax	6-phosphofructokinase, putative	0.0033	0.0239	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0366	0.0632
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0203	0.017
Trypanosoma brucei	ubiquitin-activating enzyme E1, putative	0.0036	0.0278	0.0246
Brugia malayi	hypothetical protein	0.0106	0.1334	0.2391
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0041	0.0366	0.0662
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0362	0.0626
Schistosoma mansoni	eukaryotic translation initiation factor 4h	0.0151	0.1997	0.3594
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0033	0.0239	0.0432
Trypanosoma brucei	phosphoglycerate kinase, putative	0.0142	0.187	0.1842
Trypanosoma brucei	DNA polymerase kappa, putative	0.0182	0.2453	0.2428
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0239	0.0432
Trichomonas vaginalis	flap endonuclease-1, putative	0.0059	0.0633	0.1146
Schistosoma mansoni	SET domain protein	0.0038	0.0315	0.054
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0042	0.0373	0.0646
Brugia malayi	Phosphoglycerate kinase	0.0142	0.187	0.3362
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0373	0.0373
Mycobacterium ulcerans	6-phosphofructokinase	0.0122	0.1562	0.2403
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0327	0.4623	0.8367
Leishmania major	4-coumarate:coa ligase-like protein	0.0054	0.0554	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0314	0.4428	0.8007
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0043	0.0388	0.0355
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0373	0.0676
Schistosoma mansoni	ubiquitin-activating enzyme E1b	0.0036	0.0278	0.0473
Toxoplasma gondii	exonuclease III APE	0.0043	0.0388	0.0645
Brugia malayi	exodeoxyribonuclease III family protein	0.0043	0.0388	0.0671
Brugia malayi	Isocitrate dehydrogenase	0.0019	0.0033	0.0029
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0646	0.1141
Loa Loa (eye worm)	hypothetical protein	0.006	0.0646	0.1141
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0553	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0385	0.0666
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.037	0.064
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0033	0.0239	0.0374
Entamoeba histolytica	Flap nuclease, putative	0.0059	0.0633	0.1146
Trypanosoma cruzi	DNA damage repair protein, putative	0.0038	0.0308	0.0308
Brugia malayi	AMP-binding enzyme family protein	0.0054	0.0554	0.0974
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0019	0.0033	0.0029
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0043	0.0388	0.0388
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0118	0.1506	0.1506
Echinococcus multilocularis	bloom syndrome protein	0.0103	0.1288	0.2307
Trypanosoma brucei	glucosidase, putative	0.0042	0.0373	0.0341
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0104	0.1302	0.2331
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0136	0.1774	0.1747
Echinococcus multilocularis	SUMO activating enzyme subunit 2	0.0036	0.0278	0.0473
Plasmodium falciparum	DNA repair protein REV1, putative	0.0038	0.0308	0.05
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0097	0.1191	0.1161
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0203	0.0308
Leishmania major	DNA polymerase eta, putative	0.0096	0.1173	0.1143
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0646	0.1141
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0043	0.0385	0.0666
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0239	0.0432
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0203	0.0308
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0037	0.0293	0.0261
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0019	0.0033	0.0029
Brugia malayi	polk-prov protein	0.0098	0.1211	0.2166
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0042	0.0373	0.0676
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0019	0.0033	0.0033
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0122	0.1562	0.1562
Schistosoma mansoni	hypothetical protein	0.0041	0.0362	0.0626
Schistosoma mansoni	phosphoglycerate kinase	0.0388	0.5526	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0182	0.2453	0.2428
Leishmania major	DNA polymerase kappa, putative	0.0136	0.1774	0.1747
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0055	0.0571	0.054
Brugia malayi	6-phosphofructokinase	0.0122	0.1562	0.2804
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0033	0.0029
Plasmodium falciparum	SUMO-activating enzyme subunit 2	0.0036	0.0278	0.0446
Schistosoma mansoni	blooms syndrome DNA helicase	0.0022	0.0073	0.01
Brugia malayi	ImpB/MucB/SamB family protein	0.0179	0.2415	0.4353
Trypanosoma brucei	phosphoglycerate kinase	0.0388	0.5526	0.5511
Leishmania major	DNA polymerase kappa, putative	0.0038	0.0308	0.0276
Wolbachia endosymbiont of Brugia malayi	phosphoglycerate kinase	0.0388	0.5526	1
Brugia malayi	AMP-binding enzyme family protein	0.0054	0.0554	0.0974
Leishmania major	ATP-dependent phosphofructokinase	0.0122	0.1562	0.1534
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0043	0.0388	0.0671
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0327	0.4623	0.8367
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0142	0.187	0.187
Loa Loa (eye worm)	glutaminase 2	0.0306	0.4308	0.7789
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0041	0.0366	0.0632
Trypanosoma brucei	chrX additional, unordered contigs	0.0038	0.0308	0.0276
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0042	0.0373	0.0646
Echinococcus granulosus	phosphoglycerate kinase 1	0.0388	0.5526	1
Brugia malayi	ThiF family protein	0.0036	0.0278	0.0473
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0042	0.0373	0.0676
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0037	0.0293	0.053
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0121	0.1551	0.2783
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0053	0.0532	0.0908
Loa Loa (eye worm)	hypothetical protein	0.004	0.035	0.0604
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0056	0.0587	0.1063
Entamoeba histolytica	recQ family DNA helicase	0.0022	0.0073	0.0132
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0037	0.0293	0.0293
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0308	0.0276
Loa Loa (eye worm)	6-phosphofructokinase	0.0122	0.1562	0.2804
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0038	0.0318	0.0517
Brugia malayi	ImpB/MucB/SamB family protein	0.0121	0.1551	0.2783
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0033	0.0239	0.0374
Echinococcus multilocularis	dna polymerase eta	0.0179	0.2415	0.4353
Trypanosoma brucei	DNA damage repair protein, putative	0.0038	0.0308	0.0276
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0041	0.0366	0.0662
Trypanosoma brucei	DNA damage repair protein, putative	0.0038	0.0308	0.0276
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0033	0.0239	0.0304
Plasmodium vivax	flap endonuclease 1, putative	0.0059	0.0633	0.1092
Mycobacterium ulcerans	DNA polymerase IV	0.0182	0.2453	0.4111
Trypanosoma brucei	phosphoglycerate kinase	0.0388	0.5526	0.5511
Brugia malayi	6-phosphofructokinase	0.0122	0.1562	0.2804
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.004	0.035	0.0577
Schistosoma mansoni	hypothetical protein	0.0019	0.0033	0.0028
Plasmodium falciparum	sentrin-specific protease 1	0.0056	0.0587	0.1008
Onchocerca volvulus		0.0054	0.0554	0.3947
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0043	0.0388	0.0671
Schistosoma mansoni	blooms syndrome DNA helicase	0.0082	0.0964	0.1719
Entamoeba histolytica	phosphofructokinase, putative	0.0122	0.1562	0.2827
Loa Loa (eye worm)	hypothetical protein	0.0388	0.5526	1
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0059	0.0633	0.0633
Entamoeba histolytica	recQ family helicase, putative	0.0021	0.0061	0.011
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0073	0.01
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0239	0.0432
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0054	0.0554	0.0948
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0688	1	1
Echinococcus granulosus	6 phosphofructokinase	0.0122	0.1562	0.2804
Entamoeba histolytica	hypothetical protein	0.0042	0.037	0.067
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0239	0.0432
Leishmania major	phosphoglycerate kinase C, glycosomal	0.0388	0.5526	0.5511
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.4623	0.8367
Giardia lamblia	Phosphoglycerate kinase	0.0388	0.5526	1
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0326	0.4601	0.4582
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0043	0.0388	0.0577
Schistosoma mansoni	alpha-glucosidase	0.0163	0.217	0.3908
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0042	0.0373	0.0676
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0097	0.1191	0.1191
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0136	0.1774	0.317
Echinococcus multilocularis	Eukaryotic translation initiation factor 4H	0.0151	0.1997	0.3594
Trichomonas vaginalis	rotamase, putative	0.0037	0.0306	0.0554
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0388	0.5526	0.5526
Leishmania major	alpha glucosidase II subunit, putative	0.0042	0.0373	0.0341
Schistosoma mansoni	hypothetical protein	0.0019	0.0033	0.0028
Trypanosoma brucei	unspecified product	0.0166	0.2229	0.2203
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0043	0.0385	0.0666
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0041	0.0366	0.0334
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0326	0.4601	0.4582
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0097	0.1191	0.1191
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0189	0.2562	0.4619
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0033	0.0028
Trypanosoma cruzi	DNA polymerase eta, putative	0.0096	0.1173	0.1173
Trypanosoma cruzi	DNA polymerase eta, putative	0.0179	0.2415	0.2415
Onchocerca volvulus		0.0109	0.1376	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0122	0.1562	0.2827
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0373	0.0373
Entamoeba histolytica	hypothetical protein	0.0042	0.037	0.067
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0142	0.187	0.187
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0043	0.0385	0.0639
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0203	0.0203
Echinococcus multilocularis	isocitrate dehydrogenase	0.0019	0.0033	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0179	0.2415	0.4353
Schistosoma mansoni	sumo-1-activating enzyme E1a	0.0054	0.0553	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1334	0.2391
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0203	0.0308
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0104	0.1302	0.2331
Trichomonas vaginalis	ap endonuclease, putative	0.0043	0.0388	0.0701
Giardia lamblia	Fructose-bisphosphate aldolase	0.0327	0.4623	0.8367
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.004	0.035	0.0211
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0042	0.0373	0.0646
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0104	0.1302	0.2331
Brugia malayi	isocitrate dehydrogenase	0.0019	0.0033	0.0029
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0033	0.0028
Trypanosoma cruzi	DNA damage repair protein, putative	0.0038	0.0308	0.0308
Schistosoma mansoni	alpha glucosidase	0.0042	0.0373	0.0646
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0059	0.0633	0.0602
Plasmodium falciparum	phosphoglycerate kinase	0.0388	0.5526	1
Entamoeba histolytica	phosphofructokinase, putative	0.0122	0.1562	0.2827
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0041	0.0366	0.0334
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.4623	0.8367
Mycobacterium ulcerans	acyl-CoA synthetase	0.0054	0.0554	0.0471
Schistosoma mansoni	rotamase	0.0037	0.0306	0.0524
Loa Loa (eye worm)	hypothetical protein	0.004	0.035	0.0604
Schistosoma mansoni	DNA helicase recq1	0.0043	0.0385	0.0666
Echinococcus granulosus	sumo-activating enzyme subunit 2	0.0036	0.0278	0.0473
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0054	0.0554	0.1002
Toxoplasma gondii	ThiF family protein	0.0036	0.0278	0.0446
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0059	0.0633	0.1092
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0019	0.0033	0.0029
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0122	0.1562	0.2783
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1334	0.2391
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.016	0.213	0.3492
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0308	0.0308
Trypanosoma cruzi	ubiquitin-activating enzyme, putative	0.0031	0.0204	0.0204
Plasmodium vivax	ATP-dependent DNA helicase Q1, putative	0.0021	0.0061	0.005
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0373	0.0676
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0037	0.0293	0.0261
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0041	0.0366	0.0662
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.037	0.064
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0056	0.0587	0.1034
Trypanosoma brucei	DNA polymerase kappa, putative	0.0136	0.1774	0.1747
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.007	0.079	0.1377
Treponema pallidum	phosphoglycerate kinase	0.0388	0.5526	1
Mycobacterium ulcerans	glutaminase	0.0306	0.4308	0.7666
Echinococcus multilocularis	SUMO activating enzyme subunit 1	0.0054	0.0553	0.0972
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0041	0.0366	0.0662
Echinococcus granulosus	histone lysine N methyltransferase NSD3	0.0038	0.0315	0.054
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0104	0.1302	0.2331
Giardia lamblia	DNA damage repair protein	0.0038	0.0308	0.0558
Trypanosoma brucei	unspecified product	0.0083	0.0991	0.0961
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0646	0.1141
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0033	0.0028
Echinococcus granulosus	neutral alpha glucosidase AB	0.0042	0.0373	0.0646
Leishmania major	DNA polymerase eta, putative	0.0179	0.2415	0.239
Trichomonas vaginalis	ap endonuclease, putative	0.0043	0.0388	0.0701
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0203	0.0203
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0362	0.5149	0.9313
Trypanosoma brucei	DNA polymerase IV, putative	0.0182	0.2453	0.2428
Brugia malayi	hypothetical protein	0.0042	0.037	0.064
Echinococcus granulosus	bloom syndrome protein	0.0103	0.1288	0.2307
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0054	0.0554	0.1002
Schistosoma mansoni	hypothetical protein	0.019	0.2575	0.4643
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0033	0.0029
Plasmodium vivax	SUMO-activating enzyme subunit 2, putative	0.0036	0.0278	0.0446
Plasmodium falciparum	acyl-CoA synthetase	0.004	0.035	0.0577

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	1.05 uM	PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	2.21 uM	PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1.9953 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	9.2 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10.6928 uM	PubChem BioAssay. qHTS for Inhibitors of the Phosphatase Activity of Eya2: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2134237

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1712894